pyrilamine has been researched along with Dermatitis, Atopic in 4 studies
Pyrilamine: A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.
mepyramine : An ethylenediamine derivative that is ethylenediamine in which one of the amino nitrogens is substituted by two methyl groups and the remaining amino nitrogen is substituted by a 4-methoxybenzyl and a pyridin-2-yl group.
Dermatitis, Atopic: A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pyrilamine (mepyramine) was not inhibitory in equimolar concentrations." | 2.68 | Cetirizine inhibits the in vitro and ex vivo chemotactic response of T lymphocytes and monocytes. ( Deleuran, B; Jinquan, T; Reimert, CM; Simonsen, C; Thestrup-Pedersen, K; Zachariae, C, 1995) |
| "Histamine plays significant roles in early-phase swelling via H₁ receptors and in late-phase swelling via H₃/H₄ receptors in this TPA-modified allergic dermatitis model." | 2.47 | [Roles of histamine in the exacerbated allergic dermatitis]. ( Hirasawa, N; Ohuchi, K, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Köchling, H | 1 |
| Schaper, K | 1 |
| Wilzopolski, J | 1 |
| Gutzmer, R | 1 |
| Werfel, T | 1 |
| Bäumer, W | 1 |
| Kietzmann, M | 1 |
| Rossbach, K | 1 |
| Hirasawa, N | 1 |
| Ohuchi, K | 1 |
| Fujii, M | 1 |
| Nabe, T | 1 |
| Tomozawa, J | 1 |
| Kohno, S | 1 |
| Jinquan, T | 1 |
| Reimert, CM | 1 |
| Deleuran, B | 1 |
| Zachariae, C | 1 |
| Simonsen, C | 1 |
| Thestrup-Pedersen, K | 1 |
1 review available for pyrilamine and Dermatitis, Atopic
| Article | Year |
|---|---|
[Roles of histamine in the exacerbated allergic dermatitis].
Topics: Animals; Cyclosporine; Dermatitis, Atopic; Disease Models, Animal; Drug Therapy, Combination; Histam | 2011 |
1 trial available for pyrilamine and Dermatitis, Atopic
| Article | Year |
|---|---|
Cetirizine inhibits the in vitro and ex vivo chemotactic response of T lymphocytes and monocytes.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Proteins; Cetirizine; Chemotaxis, Leukocyte; Dermatit | 1995 |
2 other studies available for pyrilamine and Dermatitis, Atopic
| Article | Year |
|---|---|
Combined treatment with H1 and H4 receptor antagonists reduces inflammation in a mouse model of atopic dermatitis.
Topics: Animals; Dermatitis, Atopic; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Com | 2017 |
Involvement of skin barrier dysfunction in itch-related scratching in special diet-fed hairless mice.
Topics: Animals; Behavior, Animal; Dermatitis, Atopic; Dose-Response Relationship, Drug; Epidermis; Erythema | 2006 |