pyrilamine has been researched along with Brain Neoplasms in 7 studies
Pyrilamine: A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.
mepyramine : An ethylenediamine derivative that is ethylenediamine in which one of the amino nitrogens is substituted by two methyl groups and the remaining amino nitrogen is substituted by a 4-methoxybenzyl and a pyridin-2-yl group.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Molecular events involved in the homologous desensitization of histamine-mediated signal transduction system in glioma cells are not well understood." | 7.79 | Homologous desensitization of histamine-mediated signal transduction system in C6 glioma cells. ( Tseng, CL; Wei, JW, 2013) |
| "In human astrocytoma U373 MG cells that express histamine H1 receptors (180 +/- 6 fmol/mg protein) but not H2 or H3 receptors, histamine stimulated mitogenesis as assessed by [3H]-thymidine incorporation (173 +/- 2% of basal; EC50, 2." | 7.71 | Histamine H1 receptor activation stimulates mitogenesis in human astrocytoma U373 MG cells. ( Arias-Montaño, JA; Hernández-Angeles, A; Ortega, A; Soria-Jasso, LE, 2001) |
| " Histamine (1 mM) induced an accumulation of inositol monophosphate ([3H]-IP1) in the U373 MG human astrocytoma cell line which increased with time in the presence of 30 mM Li+." | 7.69 | Calcium-dependence of histamine- and carbachol-induced inositol phosphate formation in human U373 MG astrocytoma cells: comparison with HeLa cells and brain slices. ( Arias-Montaño, JA; Berger, V; Young, JM, 1994) |
| "Molecular events involved in the homologous desensitization of histamine-mediated signal transduction system in glioma cells are not well understood." | 3.79 | Homologous desensitization of histamine-mediated signal transduction system in C6 glioma cells. ( Tseng, CL; Wei, JW, 2013) |
| "In human astrocytoma U373 MG cells that express histamine H1 receptors (180 +/- 6 fmol/mg protein) but not H2 or H3 receptors, histamine stimulated mitogenesis as assessed by [3H]-thymidine incorporation (173 +/- 2% of basal; EC50, 2." | 3.71 | Histamine H1 receptor activation stimulates mitogenesis in human astrocytoma U373 MG cells. ( Arias-Montaño, JA; Hernández-Angeles, A; Ortega, A; Soria-Jasso, LE, 2001) |
| " Histamine (1 mM) induced an accumulation of inositol monophosphate ([3H]-IP1) in the U373 MG human astrocytoma cell line which increased with time in the presence of 30 mM Li+." | 3.69 | Calcium-dependence of histamine- and carbachol-induced inositol phosphate formation in human U373 MG astrocytoma cells: comparison with HeLa cells and brain slices. ( Arias-Montaño, JA; Berger, V; Young, JM, 1994) |
| "The authors studied the effect of intracarotid administration of histamine on the regional cerebral blood flow (rCBF) in transplanted rat C6 glioma by the hydrogen clearance method." | 3.68 | Altered response to histamine in brain tumor vessels: the selective increase of regional cerebral blood flow in transplanted rat brain tumor. ( Fukui, M; Ikezaki, K; Natori, Y; Nomura, T, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, L | 1 |
| Kracht, J | 1 |
| Peng, S | 1 |
| Bernhardt, G | 1 |
| Buschauer, A | 1 |
| Tseng, CL | 1 |
| Wei, JW | 1 |
| Arias-Montaño, JA | 2 |
| Berger, V | 1 |
| Young, JM | 2 |
| Nomura, T | 1 |
| Ikezaki, K | 1 |
| Natori, Y | 1 |
| Fukui, M | 1 |
| Young, KW | 1 |
| Pinnock, RD | 1 |
| Gibson, WJ | 1 |
| Hernández-Angeles, A | 1 |
| Soria-Jasso, LE | 1 |
| Ortega, A | 1 |
| Ishikawa, R | 1 |
| Horio, S | 1 |
| Fukui, H | 1 |
7 other studies available for pyrilamine and Brain Neoplasms
| Article | Year |
|---|---|
Synthesis and pharmacological activity of fluorescent histamine H1 receptor antagonists related to mepyramine.
Topics: Animals; Brain Neoplasms; Fluorescent Dyes; Fura-2; Glioblastoma; Guinea Pigs; Histamine H1 Antagoni | 2003 |
Homologous desensitization of histamine-mediated signal transduction system in C6 glioma cells.
Topics: Animals; Arachidonic Acid; Brain Neoplasms; Calcium; Cell Line, Tumor; Glioma; Histamine; Inositol P | 2013 |
Calcium-dependence of histamine- and carbachol-induced inositol phosphate formation in human U373 MG astrocytoma cells: comparison with HeLa cells and brain slices.
Topics: Animals; Astrocytoma; Brain Chemistry; Brain Neoplasms; Calcium; Calcium Channel Blockers; Carbachol | 1994 |
Altered response to histamine in brain tumor vessels: the selective increase of regional cerebral blood flow in transplanted rat brain tumor.
Topics: Animals; Blood Pressure; Blood-Brain Barrier; Brain Neoplasms; Capillary Permeability; Cerebral Arte | 1993 |
Dual effects of histamine and substance P on intracellular calcium levels in human U373 MG astrocytoma cells: role of protein kinase C.
Topics: Animals; Astrocytoma; Brain Neoplasms; Calcium; Cerebellum; Colforsin; Cyclic AMP; Enzyme Inhibitors | 1998 |
Histamine H1 receptor activation stimulates mitogenesis in human astrocytoma U373 MG cells.
Topics: Astrocytoma; Brain Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Enzyme Ac | 2001 |
Insulin-induced up-regulation of histamine H1-receptors.
Topics: Astrocytoma; Brain Neoplasms; Enzyme Activators; Histamine H1 Antagonists; Humans; Inositol Phosphat | 2002 |