pyrilamine has been researched along with Brain Edema in 4 studies
Pyrilamine: A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.
mepyramine : An ethylenediamine derivative that is ethylenediamine in which one of the amino nitrogens is substituted by two methyl groups and the remaining amino nitrogen is substituted by a 4-methoxybenzyl and a pyridin-2-yl group.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The possibility that histamine plays a role in the formation of traumatic brain edema was investigated in the rat." | 7.67 | Role of histamine in traumatic brain edema. An experimental study in the rat. ( Chansouria, JP; Dey, PK; Mohanty, S; Olsson, Y; Sharma, HS; Singh, S, 1989) |
| "The possibility that histamine plays a role in the formation of traumatic brain edema was investigated in the rat." | 3.67 | Role of histamine in traumatic brain edema. An experimental study in the rat. ( Chansouria, JP; Dey, PK; Mohanty, S; Olsson, Y; Sharma, HS; Singh, S, 1989) |
| "Histamine has potent effects on cerebral blood vessels which include increased permeability and dilatation." | 1.29 | Effects of antihistaminics on experimental brain edema. ( Schilling, L; Wahl, M, 1994) |
| "In cimetidine-pretreated animals, the cerebral blood flow was significantly elevated and the plasma and brain 5-hydroxytryptamine (serotonin) levels were slightly but significantly reduced as compared with the untreated stressed group." | 1.28 | Histamine modulates heat stress-induced changes in blood-brain barrier permeability, cerebral blood flow, brain oedema and serotonin levels: an experimental study in conscious young rats. ( Cervos-Navarro, J; Dey, PK; Nyberg, F; Sharma, HS, 1992) |
| "Pretreatment with histamine H2 receptor antagonist cimetidine significantly reduced the extravasation of both the tracers and thwarted the increase of brain water content as compared to the untreated group." | 1.28 | Role of histamine in pathophysiology of heat stress in rats. ( Cervós-Navarro, J; Sharma, HS, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schilling, L | 1 |
| Wahl, M | 1 |
| Sharma, HS | 3 |
| Nyberg, F | 1 |
| Cervos-Navarro, J | 2 |
| Dey, PK | 2 |
| Mohanty, S | 1 |
| Singh, S | 1 |
| Chansouria, JP | 1 |
| Olsson, Y | 1 |
4 other studies available for pyrilamine and Brain Edema
| Article | Year |
|---|---|
Effects of antihistaminics on experimental brain edema.
Topics: Animals; Antioxidants; Benzothiazoles; Blood-Brain Barrier; Brain Edema; Dexamethasone; Freezing; Hi | 1994 |
Histamine modulates heat stress-induced changes in blood-brain barrier permeability, cerebral blood flow, brain oedema and serotonin levels: an experimental study in conscious young rats.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Cimetidine; Histamine; Hot Temperature; Male; Orga | 1992 |
Role of histamine in pathophysiology of heat stress in rats.
Topics: Animals; Blood-Brain Barrier; Body Water; Brain; Brain Edema; Cimetidine; Histamine; Hot Temperature | 1991 |
Role of histamine in traumatic brain edema. An experimental study in the rat.
Topics: Animals; Brain Edema; Brain Injuries; Cimetidine; Histamine; Male; Pyrilamine; Rats; Rats, Inbred St | 1989 |