pyrilamine has been researched along with Astrocytoma in 9 studies
Pyrilamine: A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.
mepyramine : An ethylenediamine derivative that is ethylenediamine in which one of the amino nitrogens is substituted by two methyl groups and the remaining amino nitrogen is substituted by a 4-methoxybenzyl and a pyridin-2-yl group.
Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In human astrocytoma U373 MG cells that express histamine H1 receptors (180 +/- 6 fmol/mg protein) but not H2 or H3 receptors, histamine stimulated mitogenesis as assessed by [3H]-thymidine incorporation (173 +/- 2% of basal; EC50, 2." | 7.71 | Histamine H1 receptor activation stimulates mitogenesis in human astrocytoma U373 MG cells. ( Arias-Montaño, JA; Hernández-Angeles, A; Ortega, A; Soria-Jasso, LE, 2001) |
| "We investigated the regulation by intracellular Ca2+ of agonist-induced sequestration of Gq protein-coupled histamine H1 receptors in human U373 MG astrocytoma cells." | 7.70 | Ca2+/calmodulin-mediated regulation of agonist-induced sequestration of Gq protein-coupled histamine H1 receptors in human U373 MG astrocytoma cells. ( Hishinuma, S; Naiki, A; Tsuga, H; Young, JM, 1998) |
| "We investigated Ca(2+)/calmodulin (CaM)-mediated regulation of the desensitizing process of the histamine H(1) receptor-mediated increase in intracellular Ca(2+) concentration in human U373 MG astrocytoma cells." | 7.70 | Ca(2+)/calmodulin-mediated regulation of the desensitizing process in G(q) protein-coupled histamine H(1) receptor-mediated Ca(2+) responses in human U373 MG astrocytoma cells. ( Hishinuma, S; Ogura, K, 2000) |
| " Histamine (1 mM) induced an accumulation of inositol monophosphate ([3H]-IP1) in the U373 MG human astrocytoma cell line which increased with time in the presence of 30 mM Li+." | 7.69 | Calcium-dependence of histamine- and carbachol-induced inositol phosphate formation in human U373 MG astrocytoma cells: comparison with HeLa cells and brain slices. ( Arias-Montaño, JA; Berger, V; Young, JM, 1994) |
| "The H1-histamine receptor antagonist [3H]mepyramine bound with high affinity (Kd = 3-5 nM) to membranes derived from 1321N1 human astrocytoma cells." | 7.67 | H1-histamine receptors on human astrocytoma cells. ( Harden, TK; Hepler, JR; Hughes, AR; Martin, MW; Nakahata, N, 1986) |
| "In human astrocytoma U373 MG cells that express histamine H1 receptors (180 +/- 6 fmol/mg protein) but not H2 or H3 receptors, histamine stimulated mitogenesis as assessed by [3H]-thymidine incorporation (173 +/- 2% of basal; EC50, 2." | 3.71 | Histamine H1 receptor activation stimulates mitogenesis in human astrocytoma U373 MG cells. ( Arias-Montaño, JA; Hernández-Angeles, A; Ortega, A; Soria-Jasso, LE, 2001) |
| "We investigated the regulation by intracellular Ca2+ of agonist-induced sequestration of Gq protein-coupled histamine H1 receptors in human U373 MG astrocytoma cells." | 3.70 | Ca2+/calmodulin-mediated regulation of agonist-induced sequestration of Gq protein-coupled histamine H1 receptors in human U373 MG astrocytoma cells. ( Hishinuma, S; Naiki, A; Tsuga, H; Young, JM, 1998) |
| "We investigated Ca(2+)/calmodulin (CaM)-mediated regulation of the desensitizing process of the histamine H(1) receptor-mediated increase in intracellular Ca(2+) concentration in human U373 MG astrocytoma cells." | 3.70 | Ca(2+)/calmodulin-mediated regulation of the desensitizing process in G(q) protein-coupled histamine H(1) receptor-mediated Ca(2+) responses in human U373 MG astrocytoma cells. ( Hishinuma, S; Ogura, K, 2000) |
| " Histamine (1 mM) induced an accumulation of inositol monophosphate ([3H]-IP1) in the U373 MG human astrocytoma cell line which increased with time in the presence of 30 mM Li+." | 3.69 | Calcium-dependence of histamine- and carbachol-induced inositol phosphate formation in human U373 MG astrocytoma cells: comparison with HeLa cells and brain slices. ( Arias-Montaño, JA; Berger, V; Young, JM, 1994) |
| " The human H1 receptor gene expressed in Chinese hamster ovary cells (CHOhumH1) encodes a classical histamine H1 receptor with a pharmacology similar to that of the H1 receptor found in guinea-pig cerebellum and the endogenously expressed human H1 receptor in 1321N1 astrocytoma cells as determined by [3H]-mepyramine binding studies." | 3.69 | Regulation of the human histamine H1 receptor stably expressed in Chinese hamster ovary cells. ( Fukui, H; Hijzelendoorn, JC; Leurs, R; Smit, MJ; Timmerman, H, 1996) |
| "The H1-histamine receptor antagonist [3H]mepyramine bound with high affinity (Kd = 3-5 nM) to membranes derived from 1321N1 human astrocytoma cells." | 3.67 | H1-histamine receptors on human astrocytoma cells. ( Harden, TK; Hepler, JR; Hughes, AR; Martin, MW; Nakahata, N, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 5 (55.56) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arias-Montaño, JA | 2 |
| Berger, V | 1 |
| Young, JM | 4 |
| Hishinuma, S | 3 |
| Smit, MJ | 1 |
| Timmerman, H | 1 |
| Hijzelendoorn, JC | 1 |
| Fukui, H | 2 |
| Leurs, R | 1 |
| Young, KW | 1 |
| Pinnock, RD | 1 |
| Gibson, WJ | 1 |
| Naiki, A | 1 |
| Tsuga, H | 1 |
| Ogura, K | 1 |
| Hernández-Angeles, A | 1 |
| Soria-Jasso, LE | 1 |
| Ortega, A | 1 |
| Ishikawa, R | 1 |
| Horio, S | 1 |
| Nakahata, N | 1 |
| Martin, MW | 1 |
| Hughes, AR | 1 |
| Hepler, JR | 1 |
| Harden, TK | 1 |
9 other studies available for pyrilamine and Astrocytoma
| Article | Year |
|---|---|
Calcium-dependence of histamine- and carbachol-induced inositol phosphate formation in human U373 MG astrocytoma cells: comparison with HeLa cells and brain slices.
Topics: Animals; Astrocytoma; Brain Chemistry; Brain Neoplasms; Calcium; Calcium Channel Blockers; Carbachol | 1994 |
Characteristics of the binding of [3H]-mepyramine to intact human U373 MG astrocytoma cells: evidence for histamine-induced H1-receptor internalisation.
Topics: Astrocytoma; Enzyme Activation; Histamine; Histamine H1 Antagonists; Humans; Kinetics; Phosphoric Di | 1995 |
Regulation of the human histamine H1 receptor stably expressed in Chinese hamster ovary cells.
Topics: Animals; Astrocytoma; Calcium; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Histamine; H | 1996 |
Dual effects of histamine and substance P on intracellular calcium levels in human U373 MG astrocytoma cells: role of protein kinase C.
Topics: Animals; Astrocytoma; Brain Neoplasms; Calcium; Cerebellum; Colforsin; Cyclic AMP; Enzyme Inhibitors | 1998 |
Ca2+/calmodulin-mediated regulation of agonist-induced sequestration of Gq protein-coupled histamine H1 receptors in human U373 MG astrocytoma cells.
Topics: Astrocytoma; Calcineurin Inhibitors; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodul | 1998 |
Ca(2+)/calmodulin-mediated regulation of the desensitizing process in G(q) protein-coupled histamine H(1) receptor-mediated Ca(2+) responses in human U373 MG astrocytoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Astrocytoma; Calcineurin Inhibitors; Calcium; Calcium | 2000 |
Histamine H1 receptor activation stimulates mitogenesis in human astrocytoma U373 MG cells.
Topics: Astrocytoma; Brain Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Enzyme Ac | 2001 |
Insulin-induced up-regulation of histamine H1-receptors.
Topics: Astrocytoma; Brain Neoplasms; Enzyme Activators; Histamine H1 Antagonists; Humans; Inositol Phosphat | 2002 |
H1-histamine receptors on human astrocytoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Astrocytoma; Calcium; Carbachol; Cells, Cultur | 1986 |