pyrilamine has been researched along with Asthma in 27 studies
Pyrilamine: A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.
mepyramine : An ethylenediamine derivative that is ethylenediamine in which one of the amino nitrogens is substituted by two methyl groups and the remaining amino nitrogen is substituted by a 4-methoxybenzyl and a pyridin-2-yl group.
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Asthma was induced in mice by sensitization and provocation with ovalbumin." | 7.78 | Opposite effects of mepyramine on JNJ 7777120-induced amelioration of experimentally induced asthma in mice in sensitization and provocation. ( Beermann, S; Glage, S; Jonigk, D; Neumann, D; Seifert, R, 2012) |
| "In a new model using conscious, unrestrained and ovalbumin-sensitized guinea pigs, we investigated the effects of the selective histamine H1 receptor antagonist, mepyramine, on the development of allergen-induced early and late asthmatic reactions, bronchial hyperreactivity and airway inflammation, having each animal as its own control." | 7.69 | Role of histamine in allergen-induced asthmatic reactions, bronchial hyperreactivity and inflammation in unrestrained guinea pigs. ( Meurs, H; Olymulder, CG; Santing, RE; Schraa, EO; Wachters, A; Zaagsma, J, 1994) |
| "Tracheal smooth muscle (TSM) from an ovalbumin sensitized canine model of allergic asthma showed hypersensitivity and hyper-reactivity to histamine (H) when compared to that from littermate controls in vitro." | 7.66 | Histamine pharmacology in airway smooth muscle from a canine model of asthma. ( Antonissen, LA; Bergen, J; Kepron, W; Kroeger, EA; Mitchell, RW; Stephens, NL, 1980) |
| "Asthma was induced in mice by sensitization and provocation with ovalbumin." | 3.78 | Opposite effects of mepyramine on JNJ 7777120-induced amelioration of experimentally induced asthma in mice in sensitization and provocation. ( Beermann, S; Glage, S; Jonigk, D; Neumann, D; Seifert, R, 2012) |
| "The contributions of histamine, cysteinyl leukotrienes (CysLTs) and thromboxane A2 (TXA2) to the asthmatic responses and the magnitudes of blood and lung eosinophilia at acute and chronic stages of our asthmatic model were comparatively determined." | 3.70 | Repeated antigen inhalations alter chemical mediators that cause asthmatic obstruction in guinea pigs. ( Kohno, S; Nabe, T; Tomioka, H; Yamashita, K, 1999) |
| "In a new model using conscious, unrestrained and ovalbumin-sensitized guinea pigs, we investigated the effects of the selective histamine H1 receptor antagonist, mepyramine, on the development of allergen-induced early and late asthmatic reactions, bronchial hyperreactivity and airway inflammation, having each animal as its own control." | 3.69 | Role of histamine in allergen-induced asthmatic reactions, bronchial hyperreactivity and inflammation in unrestrained guinea pigs. ( Meurs, H; Olymulder, CG; Santing, RE; Schraa, EO; Wachters, A; Zaagsma, J, 1994) |
| "The following study was performed to further characterize a primate model of asthma using classes of drugs that target allergy (pyrilamine, cetirizine), are bronchodilators for the treatment of asthma (salbutamol, salmeterol) or are anti-inflammatory (dexamethasone)." | 3.69 | Characterization of a primate model of asthma using anti-allergy/anti-asthma agents. ( Andresen, CJ; Smith, WB; Turner, CR; Watson, JW, 1996) |
| "Tracheal smooth muscle (TSM) from an ovalbumin sensitized canine model of allergic asthma showed hypersensitivity and hyper-reactivity to histamine (H) when compared to that from littermate controls in vitro." | 3.66 | Histamine pharmacology in airway smooth muscle from a canine model of asthma. ( Antonissen, LA; Bergen, J; Kepron, W; Kroeger, EA; Mitchell, RW; Stephens, NL, 1980) |
| "Pretreatment with pyrilamine, an antihistamine, suppressed the increase in RL in immature animals, whereas the remaining component of the increase in RL was seen in adult animals." | 1.30 | Effect of maturation on allergen-induced airflow obstruction and airway plasma exudation in sensitized guinea pigs. ( Arakawa, H; Lötvall, J; Mochizuki, H; Morikawa, A; Tokuyama, K, 1997) |
| "The histamine effects were specific, since they were significantly inhibited by an H1-blocker, pyrilamine, used at a concentration of 10 microM." | 1.29 | Phenotypic and functional modulation of normal human alveolar macrophages by histamine. ( Bousquet, J; Chanez, P; Godard, P; Paul-Eugène, N; Paul-Lacoste, P; Vignola, AM, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (22.22) | 18.7374 |
| 1990's | 18 (66.67) | 18.2507 |
| 2000's | 1 (3.70) | 29.6817 |
| 2010's | 2 (7.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Paris, D | 1 |
| Cottin, M | 1 |
| Demonchaux, P | 1 |
| Augert, G | 1 |
| Dupassieux, P | 1 |
| Lenoir, P | 1 |
| Peck, MJ | 1 |
| Jasserand, D | 1 |
| Riley, JP | 1 |
| Fuchs, B | 1 |
| Sjöberg, L | 1 |
| Nilsson, GP | 1 |
| Karlsson, L | 1 |
| Dahlén, SE | 2 |
| Rao, NL | 1 |
| Adner, M | 1 |
| SOUTHWELL, N | 1 |
| Beermann, S | 1 |
| Glage, S | 1 |
| Jonigk, D | 1 |
| Seifert, R | 1 |
| Neumann, D | 1 |
| Kawakami, N | 1 |
| Miyoshi, K | 1 |
| Horio, S | 1 |
| Fukui, H | 1 |
| Cade, JF | 1 |
| Clancy, RL | 1 |
| Walker, SE | 1 |
| Pain, MC | 1 |
| Hansson, G | 1 |
| Björck, T | 1 |
| Hedqvist, P | 1 |
| Granström, E | 1 |
| Dahlén, B | 1 |
| Antonissen, LA | 1 |
| Mitchell, RW | 1 |
| Kroeger, EA | 1 |
| Kepron, W | 1 |
| Stephens, NL | 1 |
| Bergen, J | 1 |
| Aibara, S | 1 |
| Mori, M | 1 |
| Tsukada, W | 1 |
| Vignola, AM | 1 |
| Chanez, P | 1 |
| Paul-Lacoste, P | 1 |
| Paul-Eugène, N | 1 |
| Godard, P | 1 |
| Bousquet, J | 1 |
| Santing, RE | 1 |
| Schraa, EO | 1 |
| Wachters, A | 1 |
| Olymulder, CG | 1 |
| Zaagsma, J | 1 |
| Meurs, H | 1 |
| Nakagawa, N | 1 |
| Obata, T | 1 |
| Kobayashi, T | 1 |
| Okada, Y | 1 |
| Nambu, F | 2 |
| Terawaki, T | 1 |
| Furuya, T | 1 |
| Muryobayashi, K | 1 |
| Sawada, M | 1 |
| Aishita, H | 1 |
| Turner, CR | 1 |
| Andresen, CJ | 1 |
| Smith, WB | 1 |
| Watson, JW | 1 |
| Heuer, HO | 1 |
| Wenz, B | 1 |
| Jennewein, HM | 1 |
| Urich, K | 1 |
| Arakawa, H | 1 |
| Tokuyama, K | 1 |
| Mochizuki, H | 1 |
| Morikawa, A | 1 |
| Lötvall, J | 1 |
| Tamaoki, J | 1 |
| Nakata, J | 1 |
| Takeyama, K | 1 |
| Chiyotani, A | 1 |
| Konno, K | 1 |
| Kagoshima, M | 1 |
| Tomomatsu, N | 1 |
| Iwahisa, Y | 1 |
| Yamaguchi, S | 1 |
| Matsuura, M | 1 |
| Kawakami, Y | 1 |
| Terasawa, M | 1 |
| Tohda, Y | 1 |
| Kubo, H | 1 |
| Haraguchi, R | 1 |
| Iwanaga, T | 1 |
| Fukuoka, M | 1 |
| Nakajima, S | 1 |
| Yamashita, K | 1 |
| Nabe, T | 1 |
| Tomioka, H | 1 |
| Kohno, S | 1 |
| Chand, N | 2 |
| Deroth, L | 1 |
| Eyre, P | 1 |
| Knight, DA | 1 |
| Phillips, MJ | 1 |
| Stewart, GA | 1 |
| Thompson, PJ | 1 |
| Sakuma, Y | 1 |
| Muramoto, K | 1 |
| Harada, K | 1 |
| Katayama, S | 1 |
| Tsunoda, H | 1 |
| Katayama, K | 1 |
| Uchida, M | 1 |
| Imanishi, N | 1 |
| Sugasawa, T | 1 |
| Morooka, S | 1 |
| Nakagawa, T | 1 |
| Mizushima, Y | 1 |
| Ishii, A | 1 |
| Motoishi, M | 1 |
| Yui, Y | 1 |
| Shida, T | 1 |
| Miyamoto, T | 1 |
| Tarayre, JP | 1 |
| Aliaga, M | 1 |
| Barbara, M | 1 |
| Tisseyre, N | 1 |
| Vieu, S | 1 |
| Tisne-Versailles, J | 1 |
| Hess, FG | 1 |
| Nolan, K | 1 |
| Diamantis, W | 1 |
| McGee, J | 1 |
| Sofia, RD | 1 |
| Webber, SE | 1 |
| Salonen, RO | 1 |
| Deffebach, ME | 1 |
| Widdicombe, JG | 1 |
1 trial available for pyrilamine and Asthma
| Article | Year |
|---|---|
Effect of leukotriene antagonist on experimental and clinical bronchial asthma.
Topics: Allergens; Anaphylaxis; Animals; Asthma; Bronchi; Bronchial Provocation Tests; Chromones; Drug Evalu | 1991 |
26 other studies available for pyrilamine and Asthma
| Article | Year |
|---|---|
Synthesis, structure-activity relationships, and pharmacological evaluation of pyrrolo[3,2,1-ij]quinoline derivatives: potent histamine and platelet activating factor antagonism and 5-lipoxygenase inhibitory properties. Potential therapeutic application i
Topics: Animals; Asthma; Female; Guinea Pigs; Histamine Antagonists; In Vitro Techniques; Lipoxygenase Inhib | 1995 |
Mast cell mediators cause early allergic bronchoconstriction in guinea-pigs in vivo: a model of relevance to asthma.
Topics: Acetates; Animals; Asthma; Bronchial Hyperreactivity; Constriction, Pathologic; Cyclopropanes; Disea | 2013 |
Anthisan in treatment of asthma and hay-fever.
Topics: Asthma; Histamine Antagonists; Humans; Hyperthermia, Induced; Pyrilamine; Rhinitis, Allergic, Season | 1948 |
Opposite effects of mepyramine on JNJ 7777120-induced amelioration of experimentally induced asthma in mice in sensitization and provocation.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Flui | 2012 |
Beta(2)-adrenergic receptor-mediated histamine H(1) receptor down-regulation: another possible advantage of beta(2) agonists in asthmatic therapy.
Topics: Adrenergic beta-Agonists; Animals; Asthma; Bronchodilator Agents; Carbazoles; CHO Cells; Cricetinae; | 2004 |
Slow-reacting substance from alveolar macrophages--a mechanism of asthma?
Topics: Animals; Asthma; Atropine; Autacoids; Chromones; Cimetidine; Ethers; Guinea Pigs; Indomethacin; Macr | 1981 |
Specific allergen induces contraction of bronchi and formation of leukotrienes C4, D4, and E4 in human asthmatic lung.
Topics: Allergens; Asthma; Bronchi; Calcimycin; Histamine; Humans; In Vitro Techniques; Leukotriene E4; Lung | 1983 |
Histamine pharmacology in airway smooth muscle from a canine model of asthma.
Topics: Airway Resistance; Anaphylaxis; Animals; Asthma; Dogs; Histamine; In Vitro Techniques; Methylhistami | 1980 |
Inhibitory effect of DS-4574 on leukotriene- or antigen-induced bronchoconstriction in guinea pigs.
Topics: Animals; Antigens; Asthma; Atropine; Bronchoconstriction; Guinea Pigs; Histamine Release; Immunizati | 1993 |
Phenotypic and functional modulation of normal human alveolar macrophages by histamine.
Topics: Adult; Aged; Asthma; Bronchoalveolar Lavage Fluid; Cells, Cultured; Cycloheximide; Dose-Response Rel | 1994 |
Role of histamine in allergen-induced asthmatic reactions, bronchial hyperreactivity and inflammation in unrestrained guinea pigs.
Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchitis; Bron | 1994 |
Effect of a peptide leukotriene receptor antagonist, ONO-1078, on guinea-pig models of asthma.
Topics: Acetylcholine; Acute-Phase Reaction; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrict | 1993 |
Characterization of a primate model of asthma using anti-allergy/anti-asthma agents.
Topics: Albuterol; Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Antigens; Asthma; Bronchoconstri | 1996 |
Pharmacological characterisation of a new model of antigen-induced pulmonary late-phase reaction in the conscious guinea pig which uses additional polymyxin B inhalation.
Topics: Administration, Inhalation; Animals; Anti-Bacterial Agents; Antigens; Asthma; Azepines; Disease Mode | 1996 |
Effect of maturation on allergen-induced airflow obstruction and airway plasma exudation in sensitized guinea pigs.
Topics: Age Factors; Airway Obstruction; Airway Resistance; Allergens; Animals; Asthma; Exudates and Transud | 1997 |
Histamine H2 receptor-mediated airway goblet cell secretion and its modulation by histamine-degrading enzymes.
Topics: Amine Oxidase (Copper-Containing); Animals; Asthma; Cimetidine; Dimaprit; Dose-Response Relationship | 1997 |
Suppressive effects of Y-24180, a receptor antagonist to platelet activating factor (PAF), on antigen-induced asthmatic responses in guinea pigs.
Topics: Administration, Oral; Aerosols; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Asthma; Azepin | 1997 |
Roles of histamine receptor in a guinea pig asthma model.
Topics: Animals; Asthma; Cimetidine; Disease Models, Animal; Guinea Pigs; Histamine Antagonists; Lung; Male; | 1998 |
Repeated antigen inhalations alter chemical mediators that cause asthmatic obstruction in guinea pigs.
Topics: Administration, Inhalation; Airway Obstruction; Aluminum Hydroxide; Animals; Antigens; Asthma; Benzo | 1999 |
Pharmacology of Schultz-Dale reaction in canine lung strip in vitro: possible model for allergic asthma.
Topics: Anaphylaxis; Animals; Asthma; Autacoids; Disease Models, Animal; Dogs; Female; Histamine H1 Antagoni | 1979 |
The interaction of acetylcholine and histamine on human bronchial smooth muscle contraction.
Topics: Acetylcholine; Asthma; Atropine; Bronchi; Dose-Response Relationship, Drug; Drug Interactions; Epith | 1991 |
Inhibitory effects of a novel PAF antagonist E6123 on anaphylactic responses in passively and actively sensitized guinea pigs and passively sensitized mice.
Topics: Administration, Inhalation; Anaphylaxis; Animals; Antigens; Asthma; Azepines; Guinea Pigs; Male; Mic | 1991 |
Effect of the selective PAF antagonist SM-10661 on an asthmatic model. 1. Effect on passive anaphylactic bronchoconstriction in guinea pigs.
Topics: Anaphylaxis; Animals; Asthma; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationshi | 1991 |
Pharmacological modulation of a model of bronchial inflammation after aerosol-induced active anaphylactic shock in conscious guinea pigs.
Topics: Albuterol; Anaphylaxis; Animals; Asthma; Bronchitis; Bronchoalveolar Lavage Fluid; Cromolyn Sodium; | 1991 |
Aeroallergen-induced immediate asthmatic responses and late-phase associated pulmonary eosinophilia in the guinea pig: effect of methylprednisolone and mepyramine.
Topics: Administration, Oral; Aerosols; Aminopyridines; Animals; Asthma; Drug Administration Schedule; Guine | 1990 |
Effects of antigen on tracheal circulation and smooth muscle in sheep of different ages.
Topics: Age Factors; Animals; Antigens, Helminth; Ascaris; Asthma; Female; Indomethacin; Male; Muscle Contra | 1989 |