Page last updated: 2024-11-03

pyrilamine and Anasarca

pyrilamine has been researched along with Anasarca in 36 studies

Pyrilamine: A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.
mepyramine : An ethylenediamine derivative that is ethylenediamine in which one of the amino nitrogens is substituted by two methyl groups and the remaining amino nitrogen is substituted by a 4-methoxybenzyl and a pyridin-2-yl group.

Research Excerpts

ExcerptRelevanceReference
"The aim of this study was to evaluate the effect of angiotensin II on models of acute inflammation."7.73Angiotensin II potentiates inflammatory edema in rats: Role of mast cell degranulation. ( Alcantara, C; Brito, GA; Carvalho, RF; Cunha, FQ; Falcão, RA; Leitão, RF; Lima, RC; Ribeiro, RA; Souza, MH, 2006)
"The present study used plethysmometry to examine oedema following local injection of selective adenosine A(1), A(2) and A(3) receptor agonists and inhibitors of adenosine metabolism into the hindpaw of the rat."7.70Acute paw oedema induced by local injection of adenosine A(1), A(2) and A(3) receptor agonists. ( Liu, XJ; Reid, A; Sawynok, J, 1999)
"15 mumol/paw) significantly reduced both bradykinin- and 5-hydroxytryptamine-induced rat paw oedema."7.69Effect of arginine analogues on rat hind paw oedema and mast cell activation in vitro. ( Antunes, E; Cirino, G; De Luca, IM; De Nucci, G; Giraldelo, CM; Hyslop, S; Muscará, MN; Zappellini, A; Zatz, R, 1994)
"The leukotriene synthesis inhibitor (LSI) BAY X 1005 was tested in the arachidonic acid (AA)-induced mouse ear inflammation test (AA-MEIT) alone and in combination with other representative anti-inflammatory compounds for antiedematous effects."7.69Antiedematous effects of combination therapies with the leukotriene synthesis inhibitor BAY X 1005 in the archidonic acid-induced mouse ear inflammation test. ( Burchardt, ER; Müller-Peddinghaus, R, 1997)
"The effect of three histamine H2-antagonists, cimetidine, ranitidine, and loxtidine, on acute rat paw oedema induced by histamine, carrageenan or complete Freund's adjuvant, have been examined."7.67Effect of histamine H2-receptor antagonists on acute inflammatory of the rat paw oedema. ( Ezeamuzie, CI; Umezurike, CC, 1989)
" In contrast to when mepyramine was used, there was a significant inhibition of carrageenan oedema when cimetidine was used."7.66Carrageenan-induced oedema in the rat paw - histamine participation. ( Maśliński, S; Stochla, K, 1982)
"Intra-arterial fusions of histamine cause vasodilation of resistance vessels, extravasation of albumin and oedema in cat skeletal muscle."7.66Histamine H1- and H2- receptor antagonists reduce histamine-induced increases in vascular permeability and oedema formation in cat skeletal muscle. ( Flynn, SB; Owen, DA, 1979)
" Cortisone, mepyramine and sodium salicylate were effective in reducing histamine-induced inflammation, sodium salicylate being less active in the adrenalectomized animal."7.64Some inhibitors of histamine-induced and formaldehyde-induced inflammation in mice. ( NORTHOVER, BJ; SUBRAMANIAN, G, 1961)
"The aim of this study was to evaluate the effect of angiotensin II on models of acute inflammation."3.73Angiotensin II potentiates inflammatory edema in rats: Role of mast cell degranulation. ( Alcantara, C; Brito, GA; Carvalho, RF; Cunha, FQ; Falcão, RA; Leitão, RF; Lima, RC; Ribeiro, RA; Souza, MH, 2006)
"The present study used plethysmometry to examine oedema following local injection of selective adenosine A(1), A(2) and A(3) receptor agonists and inhibitors of adenosine metabolism into the hindpaw of the rat."3.70Acute paw oedema induced by local injection of adenosine A(1), A(2) and A(3) receptor agonists. ( Liu, XJ; Reid, A; Sawynok, J, 1999)
"15 mumol/paw) significantly reduced both bradykinin- and 5-hydroxytryptamine-induced rat paw oedema."3.69Effect of arginine analogues on rat hind paw oedema and mast cell activation in vitro. ( Antunes, E; Cirino, G; De Luca, IM; De Nucci, G; Giraldelo, CM; Hyslop, S; Muscará, MN; Zappellini, A; Zatz, R, 1994)
"The leukotriene synthesis inhibitor (LSI) BAY X 1005 was tested in the arachidonic acid (AA)-induced mouse ear inflammation test (AA-MEIT) alone and in combination with other representative anti-inflammatory compounds for antiedematous effects."3.69Antiedematous effects of combination therapies with the leukotriene synthesis inhibitor BAY X 1005 in the archidonic acid-induced mouse ear inflammation test. ( Burchardt, ER; Müller-Peddinghaus, R, 1997)
"The effect of three histamine H2-antagonists, cimetidine, ranitidine, and loxtidine, on acute rat paw oedema induced by histamine, carrageenan or complete Freund's adjuvant, have been examined."3.67Effect of histamine H2-receptor antagonists on acute inflammatory of the rat paw oedema. ( Ezeamuzie, CI; Umezurike, CC, 1989)
" In contrast to when mepyramine was used, there was a significant inhibition of carrageenan oedema when cimetidine was used."3.66Carrageenan-induced oedema in the rat paw - histamine participation. ( Maśliński, S; Stochla, K, 1982)
"Intra-arterial fusions of histamine cause vasodilation of resistance vessels, extravasation of albumin and oedema in cat skeletal muscle."3.66Histamine H1- and H2- receptor antagonists reduce histamine-induced increases in vascular permeability and oedema formation in cat skeletal muscle. ( Flynn, SB; Owen, DA, 1979)
" Cortisone, mepyramine and sodium salicylate were effective in reducing histamine-induced inflammation, sodium salicylate being less active in the adrenalectomized animal."3.64Some inhibitors of histamine-induced and formaldehyde-induced inflammation in mice. ( NORTHOVER, BJ; SUBRAMANIAN, G, 1961)
"(AR) has been used to treat pain and inflammation in Korea."1.32Mechanism of anti-nociceptive effects of Asarum sieboldii Miq. radix: potential role of bradykinin, histamine and opioid receptor-mediated pathways. ( Gao Zhang, C; Kim, SJ; Taek Lim, J, 2003)
"Hind paw edema was induced in male Wister rats by the subplantar injection of venom (12."1.32Pharmacological and histopathological characterization of Bothrops lanceolatus (Fer de lance) venom-induced edema. ( Bon, C; Cruz-Höfling, MA; Ferreira de Araújo, PM; Guimarães, AQ; Lôbo de Araújo, A, 2004)
" The amount of dye extracted from the paw showed a clear dose-response relationship to the dose of each agonist injected into the paw."1.28Assessment of vascular permeability increase in the mouse by dye leakage during paw edema. ( Hayashi, M; Oh-ishi, S; Qu, XF; Yamaki, K, 1990)
"Zymosan-oedema was inhibited by mepyramine and methysergide and by leucopenia."1.27Further studies of the mechanism of counter irritation by turpentine. ( Damas, J; Deflandre, E; Remacle-Volon, G, 1986)
" Vaccinium myrtillus anthocyanosides by oral route inhibited carrageein paw oedema in rats showing a dose-response relationship."1.26Studies on Vaccinium myrtillus anthocyanosides. I. Vasoprotective and antiinflammatory activity. ( Cristoni, A; Lietti, A; Picci, M, 1976)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199016 (44.44)18.7374
1990's9 (25.00)18.2507
2000's10 (27.78)29.6817
2010's1 (2.78)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bernardes, CP1
Menaldo, DL1
Mamede, CC1
Zoccal, KF1
Cintra, AC1
Faccioli, LH2
Stanziola, L1
de Oliveira, F1
Sampaio, SV1
Kim, SJ1
Gao Zhang, C1
Taek Lim, J1
ROWLEY, DA1
BENDITT, EP1
NORTHOVER, BJ1
SUBRAMANIAN, G1
Barbosa, AM1
do Amaral, RO1
Teixeira, CF1
Hyslop, S2
Cogo, JC1
Guimarães, AQ1
Cruz-Höfling, MA1
Ferreira de Araújo, PM1
Bon, C1
Lôbo de Araújo, A1
de Paula, L1
Santos, WF1
Malheiro, A1
Carlos, D1
Carvalho, RF1
Ribeiro, RA1
Falcão, RA1
Lima, RC1
Leitão, RF1
Alcantara, C1
Souza, MH1
Cunha, FQ1
Brito, GA1
Tessier, J1
Green, C1
Padgett, D1
Zhao, W1
Schwartz, L1
Hughes, M1
Hewlett, E1
Liu, T1
Bai, ZT1
Pang, XY1
Chai, ZF1
Jiang, F1
Ji, YH1
Strettle, RJ1
Bates, RF1
Buckley, GA1
Stochla, K1
Maśliński, S1
Lundberg, JM1
Saria, A1
Rosell, S1
Folkers, K1
Katz, LB1
Theobald, HM1
Bookstaff, RC1
Peterson, RE1
Das, N1
Rao, YV1
Das, PK1
Bhattacharya, SK1
Giraldelo, CM1
Zappellini, A1
Muscará, MN1
De Luca, IM1
Cirino, G1
Zatz, R1
De Nucci, G2
Antunes, E3
Wilsoncroft, P2
Euzger, H1
Brain, SD3
Souza Pinto, JC1
Remacle-Volon, G2
Sampaio, CA1
Damas, J2
Palframan, RT1
Costa, SK2
Burchardt, ER1
Müller-Peddinghaus, R1
Cao, T1
Gerard, NP1
Sawynok, J1
Reid, A1
Liu, XJ1
Ferreira, PK1
Campos, MM1
Calixto, JB1
Linardi, A1
da Silva, GR1
Olsen, UB1
Eltorp, CT1
Ingvardsen, BK1
Jørgensen, TK1
Lundbaek, JA1
Thomsen, C1
Hansen, AJ1
Lietti, A1
Cristoni, A1
Picci, M1
Flynn, SB1
Owen, DA1
Clark, KE1
Farley, DB1
Van Orden, DE1
Brody, MJ1
Dunn, CJ2
Willoughby, DA2
Banks, BE1
Dempsey, CE1
Vernon, CA1
Warner, JA1
Yamey, J1
Qu, XF1
Hayashi, M1
Yamaki, K1
Oh-ishi, S1
Saeki, K1
Oishi, R1
Nishibori, M1
Itoh, Y1
Ezeamuzie, CI1
Umezurike, CC1
Ohuchi, K1
Watanabe, M1
Takahashi, C1
Hayashi, Y1
Hirasawa, N1
Tsurufuji, S1
Fujiki, H1
Sugimura, T1
Deflandre, E1

Other Studies

36 other studies available for pyrilamine and Anasarca

ArticleYear
Evaluation of the local inflammatory events induced by BpirMP, a metalloproteinase from Bothrops pirajai venom.
    Molecular immunology, 2015, Volume: 68, Issue:2 Pt B

    Topics: Animals; Bothrops; Cell Degranulation; Cromolyn Sodium; Crotalid Venoms; Cyclooxygenase Inhibitors;

2015
Mechanism of anti-nociceptive effects of Asarum sieboldii Miq. radix: potential role of bradykinin, histamine and opioid receptor-mediated pathways.
    Journal of ethnopharmacology, 2003, Volume: 88, Issue:1

    Topics: Analgesics, Non-Narcotic; Animals; Asarum; Bradykinin; Carrageenan; Edema; Guinea Pigs; Histamine; I

2003
5-Hydroxytryptamine and histamine as mediators of the vascular injury produced by agents which damage mast cells in rats.
    The Journal of experimental medicine, 1956, Apr-01, Volume: 103, Issue:4

    Topics: Animals; Blood Vessels; Edema; Histamine; Male; Mast Cells; Pyrilamine; Rats; Serotonin; Serotonin A

1956
Some inhibitors of histamine-induced and formaldehyde-induced inflammation in mice.
    British journal of pharmacology and chemotherapy, 1961, Volume: 16

    Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Antipyretics; Cortisone; Edema; Formaldehyde; Histami

1961
Pharmacological characterization of mouse hind paw oedema induced by Bothrops insularis (jararaca ilhoa) snake venom.
    Toxicon : official journal of the International Society on Toxinology, 2003, Volume: 42, Issue:5

    Topics: Animals; Antivenins; Blood Proteins; Bothrops; Crotalid Venoms; Cyclooxygenase Inhibitors; Cyprohept

2003
Pharmacological and histopathological characterization of Bothrops lanceolatus (Fer de lance) venom-induced edema.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2004, Volume: 53, Issue:7

    Topics: Adrenergic beta-Antagonists; Animals; Antiemetics; Arachidonic Acid; Bothrops; Bradykinin; Cardiovas

2004
Differential modulation of cell recruitment and acute edema in a model of Polybia paulista venom-induced inflammation.
    International immunopharmacology, 2006, Volume: 6, Issue:2

    Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cimetidine; Dose-Response Relations

2006
Angiotensin II potentiates inflammatory edema in rats: Role of mast cell degranulation.
    European journal of pharmacology, 2006, Jul-01, Volume: 540, Issue:1-3

    Topics: Acute Disease; Angiotensin II; Animals; Anti-Allergic Agents; Carrageenan; Cell Degranulation; Cell

2006
Contributions of histamine, prostanoids, and neurokinins to edema elicited by edema toxin from Bacillus anthracis.
    Infection and immunity, 2007, Volume: 75, Issue:4

    Topics: Animals; Antigens, Bacterial; Aprepitant; Bacillus anthracis; Bacterial Toxins; Capillary Permeabili

2007
Degranulation of mast cells and histamine release involved in rat pain-related behaviors and edema induced by scorpion Buthus martensi Karch venom.
    European journal of pharmacology, 2007, Dec-01, Volume: 575, Issue:1-3

    Topics: Animals; Chlorpheniramine; Cimetidine; Dose-Response Relationship, Drug; Edema; Histamine Antagonist

2007
Evidence for a direct anti-inflammatory action of calcitonin: inhibition of histamine-induced mouse pinnal oedema by porcine calcitonin.
    The Journal of pharmacy and pharmacology, 1980, Volume: 32, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Calcitonin; Calcium; Ear Diseases; Edema; Histamine; Histamine H1

1980
Carrageenan-induced oedema in the rat paw - histamine participation.
    Agents and actions, 1982, Volume: 12, Issue:1-2

    Topics: Animals; Carrageenan; Cimetidine; Edema; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonis

1982
A substance P antagonist inhibits heat-induced oedema in the rat skin.
    Acta physiologica Scandinavica, 1984, Volume: 120, Issue:1

    Topics: Animals; Cimetidine; Edema; Electric Stimulation; Hot Temperature; Male; Nerve Fibers; Peptide Fragm

1984
Characterization of the enhanced paw edema response to carrageenan and dextran in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated rats.
    The Journal of pharmacology and experimental therapeutics, 1984, Volume: 230, Issue:3

    Topics: Animals; Bradykinin; Carrageenan; Cyproheptadine; Dextrans; Dinoprostone; Dioxins; Drug Interactions

1984
Effect of centrally administered monoaminergic & cholinergic receptor antagonists on carrageenin-induced pedal edema in rats.
    Indian journal of experimental biology, 1982, Volume: 20, Issue:5

    Topics: Animals; Atropine; Carrageenan; Edema; Female; Haloperidol; Male; Methysergide; Phentolamine; Propra

1982
Effect of arginine analogues on rat hind paw oedema and mast cell activation in vitro.
    European journal of pharmacology, 1994, May-12, Volume: 257, Issue:1-2

    Topics: Animals; Arginine; Bradykinin; Edema; Hindlimb; Histamine Release; Inflammation; Male; Mast Cells; M

1994
Effect of a neurokinin-1 (NK1) receptor antagonist on oedema formation induced by tachykinins, carrageenin and an allergic response in guinea-pig skin.
    Neuropeptides, 1994, Volume: 26, Issue:6

    Topics: Animals; Bradykinin; Calcitonin Gene-Related Peptide; Carrageenan; Edema; Guinea Pigs; Indoles; Infl

1994
Collagenase-induced oedema in the rat paw and the kinin system.
    European journal of pharmacology, 1995, Feb-14, Volume: 274, Issue:1-3

    Topics: Animals; Arginine; Azepines; Bradykinin; Collagenases; Edema; Female; Heparin; Hindlimb; Indomethaci

1995
The effect of a tachykinin NK1 receptor antagonist, SR140333, on oedema formation induced in rat skin by venom from the Phoneutria nigriventer spider.
    British journal of pharmacology, 1996, Volume: 118, Issue:2

    Topics: Animals; Edema; Male; Methysergide; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidine

1996
Antiedematous effects of combination therapies with the leukotriene synthesis inhibitor BAY X 1005 in the archidonic acid-induced mouse ear inflammation test.
    Prostaglandins, leukotrienes, and essential fatty acids, 1997, Volume: 56, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Disease Models, Animal; Drug The

1997
Use of NK(1) knockout mice to analyze substance P-induced edema formation.
    The American journal of physiology, 1999, Volume: 277, Issue:2

    Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Edema; Female; Histamine H1 Antagonists; Injec

1999
Acute paw oedema induced by local injection of adenosine A(1), A(2) and A(3) receptor agonists.
    European journal of pharmacology, 1999, Dec-15, Volume: 386, Issue:2-3

    Topics: Acute Disease; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Caffeine; Drug

1999
The role of sensorial neuropeptides in the edematogenic responses mediated by B(1) agonist des-Arg(9)-BK in rats pre-treated with LPS.
    Regulatory peptides, 2000, May-10, Volume: 89, Issue:1-3

    Topics: Animals; Benzamides; Bradykinin; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Re

2000
Involvement of kinins, mast cells and sensory neurons in the plasma exudation and paw oedema induced by staphylococcal enterotoxin B in the mouse.
    European journal of pharmacology, 2000, Jul-07, Volume: 399, Issue:2-3

    Topics: Animals; Benzamides; Bradykinin; Capillary Permeability; Capsaicin; Diabetes Mellitus, Experimental;

2000
ReN 1869, a novel tricyclic antihistamine, is active against neurogenic pain and inflammation.
    European journal of pharmacology, 2002, Jan-18, Volume: 435, Issue:1

    Topics: Animals; Benzoquinones; Binding Sites; Calcitonin Gene-Related Peptide; Calcium; Calcium Channels; C

2002
Studies on Vaccinium myrtillus anthocyanosides. I. Vasoprotective and antiinflammatory activity.
    Arzneimittel-Forschung, 1976, Volume: 26, Issue:5

    Topics: Animals; Anthocyanins; Anti-Inflammatory Agents; Bradykinin; Capillary Permeability; Capillary Resis

1976
Histamine H1- and H2- receptor antagonists reduce histamine-induced increases in vascular permeability and oedema formation in cat skeletal muscle.
    Agents and actions, 1979, Volume: 9, Issue:5-6

    Topics: Animals; Bradykinin; Capillary Permeability; Cats; Edema; Female; Histamine; Histamine H1 Antagonist

1979
Estrogen-induced uterine hyperemia and edema persist during histamine receptor blockade.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1977, Volume: 156, Issue:3

    Topics: Animals; Burimamide; Capillary Permeability; Edema; Estradiol; Female; Hyperemia; Pyrilamine; Rats;

1977
The response of the newborn rat to injury. I. Vascular and humoral aspects.
    The Journal of pathology, 1975, Volume: 116, Issue:3

    Topics: Age Factors; Albumins; Animals; Animals, Newborn; Bradykinin; Capillary Permeability; Carrageenan; C

1975
The response of the newborn rat to intraleural dextran: vascular and cellular aspects.
    Agents and actions, 1975, Volume: 5, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Cyproheptadine; Dextrans; Edema; Exudates and Transudates; Hindlim

1975
Anti-inflammatory activity of bee venom peptide 401 (mast cell degranulating peptide) and compound 48/80 results from mast cell degranulation in vivo.
    British journal of pharmacology, 1990, Volume: 99, Issue:2

    Topics: Allergens; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bee Venoms; Carrageenan; Cimetidine; Cy

1990
Assessment of vascular permeability increase in the mouse by dye leakage during paw edema.
    Japanese journal of pharmacology, 1990, Volume: 52, Issue:3

    Topics: Animals; Bradykinin; Capillary Permeability; Coloring Agents; Dose-Response Relationship, Drug; Edem

1990
Effects of isofloxythepin on central and peripheral histamine systems.
    Japanese journal of pharmacology, 1989, Volume: 50, Issue:1

    Topics: Animals; Antipsychotic Agents; Brain Chemistry; Central Nervous System; Dibenzothiepins; Edema; Fema

1989
Effect of histamine H2-receptor antagonists on acute inflammatory of the rat paw oedema.
    The Journal of pharmacy and pharmacology, 1989, Volume: 41, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cimetidine; Edema; Freund's Adjuvant;

1989
Analysis of tumor-promoter-induced inflammation in rats: participation of histamine and prostaglandin E2.
    Biochimica et biophysica acta, 1987, Aug-13, Volume: 925, Issue:2

    Topics: Animals; Capillary Permeability; Dinoprostone; Edema; Histamine; Indomethacin; Inflammation; Lyngbya

1987
Further studies of the mechanism of counter irritation by turpentine.
    Naunyn-Schmiedeberg's archives of pharmacology, 1986, Volume: 332, Issue:2

    Topics: Animals; Blood Sedimentation; Captopril; Carrageenan; Edema; Female; Inflammation; Kininogens; Leuko

1986