pyrilamine has been researched along with Anaplastic Astrocytoma in 9 studies
Pyrilamine: A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.
mepyramine : An ethylenediamine derivative that is ethylenediamine in which one of the amino nitrogens is substituted by two methyl groups and the remaining amino nitrogen is substituted by a 4-methoxybenzyl and a pyridin-2-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In human astrocytoma U373 MG cells that express histamine H1 receptors (180 +/- 6 fmol/mg protein) but not H2 or H3 receptors, histamine stimulated mitogenesis as assessed by [3H]-thymidine incorporation (173 +/- 2% of basal; EC50, 2." | 7.71 | Histamine H1 receptor activation stimulates mitogenesis in human astrocytoma U373 MG cells. ( Arias-Montaño, JA; Hernández-Angeles, A; Ortega, A; Soria-Jasso, LE, 2001) |
| "We investigated the regulation by intracellular Ca2+ of agonist-induced sequestration of Gq protein-coupled histamine H1 receptors in human U373 MG astrocytoma cells." | 7.70 | Ca2+/calmodulin-mediated regulation of agonist-induced sequestration of Gq protein-coupled histamine H1 receptors in human U373 MG astrocytoma cells. ( Hishinuma, S; Naiki, A; Tsuga, H; Young, JM, 1998) |
| "We investigated Ca(2+)/calmodulin (CaM)-mediated regulation of the desensitizing process of the histamine H(1) receptor-mediated increase in intracellular Ca(2+) concentration in human U373 MG astrocytoma cells." | 7.70 | Ca(2+)/calmodulin-mediated regulation of the desensitizing process in G(q) protein-coupled histamine H(1) receptor-mediated Ca(2+) responses in human U373 MG astrocytoma cells. ( Hishinuma, S; Ogura, K, 2000) |
| " Histamine (1 mM) induced an accumulation of inositol monophosphate ([3H]-IP1) in the U373 MG human astrocytoma cell line which increased with time in the presence of 30 mM Li+." | 7.69 | Calcium-dependence of histamine- and carbachol-induced inositol phosphate formation in human U373 MG astrocytoma cells: comparison with HeLa cells and brain slices. ( Arias-Montaño, JA; Berger, V; Young, JM, 1994) |
| "The H1-histamine receptor antagonist [3H]mepyramine bound with high affinity (Kd = 3-5 nM) to membranes derived from 1321N1 human astrocytoma cells." | 7.67 | H1-histamine receptors on human astrocytoma cells. ( Harden, TK; Hepler, JR; Hughes, AR; Martin, MW; Nakahata, N, 1986) |
| "In human astrocytoma U373 MG cells that express histamine H1 receptors (180 +/- 6 fmol/mg protein) but not H2 or H3 receptors, histamine stimulated mitogenesis as assessed by [3H]-thymidine incorporation (173 +/- 2% of basal; EC50, 2." | 3.71 | Histamine H1 receptor activation stimulates mitogenesis in human astrocytoma U373 MG cells. ( Arias-Montaño, JA; Hernández-Angeles, A; Ortega, A; Soria-Jasso, LE, 2001) |
| "We investigated the regulation by intracellular Ca2+ of agonist-induced sequestration of Gq protein-coupled histamine H1 receptors in human U373 MG astrocytoma cells." | 3.70 | Ca2+/calmodulin-mediated regulation of agonist-induced sequestration of Gq protein-coupled histamine H1 receptors in human U373 MG astrocytoma cells. ( Hishinuma, S; Naiki, A; Tsuga, H; Young, JM, 1998) |
| "We investigated Ca(2+)/calmodulin (CaM)-mediated regulation of the desensitizing process of the histamine H(1) receptor-mediated increase in intracellular Ca(2+) concentration in human U373 MG astrocytoma cells." | 3.70 | Ca(2+)/calmodulin-mediated regulation of the desensitizing process in G(q) protein-coupled histamine H(1) receptor-mediated Ca(2+) responses in human U373 MG astrocytoma cells. ( Hishinuma, S; Ogura, K, 2000) |
| " Histamine (1 mM) induced an accumulation of inositol monophosphate ([3H]-IP1) in the U373 MG human astrocytoma cell line which increased with time in the presence of 30 mM Li+." | 3.69 | Calcium-dependence of histamine- and carbachol-induced inositol phosphate formation in human U373 MG astrocytoma cells: comparison with HeLa cells and brain slices. ( Arias-Montaño, JA; Berger, V; Young, JM, 1994) |
| " The human H1 receptor gene expressed in Chinese hamster ovary cells (CHOhumH1) encodes a classical histamine H1 receptor with a pharmacology similar to that of the H1 receptor found in guinea-pig cerebellum and the endogenously expressed human H1 receptor in 1321N1 astrocytoma cells as determined by [3H]-mepyramine binding studies." | 3.69 | Regulation of the human histamine H1 receptor stably expressed in Chinese hamster ovary cells. ( Fukui, H; Hijzelendoorn, JC; Leurs, R; Smit, MJ; Timmerman, H, 1996) |
| "The H1-histamine receptor antagonist [3H]mepyramine bound with high affinity (Kd = 3-5 nM) to membranes derived from 1321N1 human astrocytoma cells." | 3.67 | H1-histamine receptors on human astrocytoma cells. ( Harden, TK; Hepler, JR; Hughes, AR; Martin, MW; Nakahata, N, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 5 (55.56) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arias-Montaño, JA | 2 |
| Berger, V | 1 |
| Young, JM | 4 |
| Hishinuma, S | 3 |
| Smit, MJ | 1 |
| Timmerman, H | 1 |
| Hijzelendoorn, JC | 1 |
| Fukui, H | 2 |
| Leurs, R | 1 |
| Young, KW | 1 |
| Pinnock, RD | 1 |
| Gibson, WJ | 1 |
| Naiki, A | 1 |
| Tsuga, H | 1 |
| Ogura, K | 1 |
| Hernández-Angeles, A | 1 |
| Soria-Jasso, LE | 1 |
| Ortega, A | 1 |
| Ishikawa, R | 1 |
| Horio, S | 1 |
| Nakahata, N | 1 |
| Martin, MW | 1 |
| Hughes, AR | 1 |
| Hepler, JR | 1 |
| Harden, TK | 1 |
9 other studies available for pyrilamine and Anaplastic Astrocytoma
| Article | Year |
|---|---|
Calcium-dependence of histamine- and carbachol-induced inositol phosphate formation in human U373 MG astrocytoma cells: comparison with HeLa cells and brain slices.
Topics: Animals; Astrocytoma; Brain Chemistry; Brain Neoplasms; Calcium; Calcium Channel Blockers; Carbachol | 1994 |
Characteristics of the binding of [3H]-mepyramine to intact human U373 MG astrocytoma cells: evidence for histamine-induced H1-receptor internalisation.
Topics: Astrocytoma; Enzyme Activation; Histamine; Histamine H1 Antagonists; Humans; Kinetics; Phosphoric Di | 1995 |
Regulation of the human histamine H1 receptor stably expressed in Chinese hamster ovary cells.
Topics: Animals; Astrocytoma; Calcium; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Histamine; H | 1996 |
Dual effects of histamine and substance P on intracellular calcium levels in human U373 MG astrocytoma cells: role of protein kinase C.
Topics: Animals; Astrocytoma; Brain Neoplasms; Calcium; Cerebellum; Colforsin; Cyclic AMP; Enzyme Inhibitors | 1998 |
Ca2+/calmodulin-mediated regulation of agonist-induced sequestration of Gq protein-coupled histamine H1 receptors in human U373 MG astrocytoma cells.
Topics: Astrocytoma; Calcineurin Inhibitors; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodul | 1998 |
Ca(2+)/calmodulin-mediated regulation of the desensitizing process in G(q) protein-coupled histamine H(1) receptor-mediated Ca(2+) responses in human U373 MG astrocytoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Astrocytoma; Calcineurin Inhibitors; Calcium; Calcium | 2000 |
Histamine H1 receptor activation stimulates mitogenesis in human astrocytoma U373 MG cells.
Topics: Astrocytoma; Brain Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Enzyme Ac | 2001 |
Insulin-induced up-regulation of histamine H1-receptors.
Topics: Astrocytoma; Brain Neoplasms; Enzyme Activators; Histamine H1 Antagonists; Humans; Inositol Phosphat | 2002 |
H1-histamine receptors on human astrocytoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Astrocytoma; Calcium; Carbachol; Cells, Cultur | 1986 |