pyrilamine has been researched along with Ache in 19 studies
Pyrilamine: A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.
mepyramine : An ethylenediamine derivative that is ethylenediamine in which one of the amino nitrogens is substituted by two methyl groups and the remaining amino nitrogen is substituted by a 4-methoxybenzyl and a pyridin-2-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We investigated whether 3-iodothyroacetic acid (TA1), by releasing histamine, induces itch and increases sensitization to noxious and painful heat stimuli." | 7.81 | 3-iodothyroacetic acid, a metabolite of thyroid hormone, induces itch and reduces threshold to noxious and to painful heat stimuli in mice. ( De Siena, G; Laurino, A; Masi, A; Musilli, C; Raimondi, L; Resta, F; Zucchi, R, 2015) |
| "Histamine and calcitonin gene-related peptide (CGRP) contribute to the pain perception." | 7.77 | Interaction of histamine and calcitonin gene-related peptide in the formalin induced pain perception in rats. ( Ghasri, S; Hamzely, A; Khoshkholgh Sima, B; Mobarakeh, JI; Nezhad, RM; Nunoki, K; Rahimi, AA; Takahashi, K; Torkaman-Boutorabi, A; Yanai, K, 2011) |
| "Although TRPA1, SP, histamine and 5-hydroxytryptamine (5-HT) have recognized contribution to nociceptive mechanisms, little is known about how they interact with each other to mediate inflammatory pain in vivo." | 3.85 | TRPA1, substance P, histamine and 5-hydroxytryptamine interact in an interdependent way to induce nociception. ( de Oliveira Borges, M; Fischer, L; Lavoranti, MI; Martynhak, BJ; Miksza, AF; Parada, CA; Sardi, NF; Tambeli, CH, 2017) |
| " We investigated whether 3-iodothyroacetic acid (TA1), by releasing histamine, induces itch and increases sensitization to noxious and painful heat stimuli." | 3.81 | 3-iodothyroacetic acid, a metabolite of thyroid hormone, induces itch and reduces threshold to noxious and to painful heat stimuli in mice. ( De Siena, G; Laurino, A; Masi, A; Musilli, C; Raimondi, L; Resta, F; Zucchi, R, 2015) |
| "Histamine and calcitonin gene-related peptide (CGRP) contribute to the pain perception." | 3.77 | Interaction of histamine and calcitonin gene-related peptide in the formalin induced pain perception in rats. ( Ghasri, S; Hamzely, A; Khoshkholgh Sima, B; Mobarakeh, JI; Nezhad, RM; Nunoki, K; Rahimi, AA; Takahashi, K; Torkaman-Boutorabi, A; Yanai, K, 2011) |
| "Itch and pain were scored on a visual analogue scale at regular intervals." | 2.70 | Topically applied aspirin decreases histamine-induced wheal and flare reactions in normal and SLS-inflamed skin, but does not decrease itch. A randomized, double-blind and placebo-controlled human study. ( Benfeldt, E; Jensen, SB; Menné, T; Serup, J; Thomsen, JS, 2002) |
| "Dysmenorrhea was more prevalent among nutrition and psychology students than among medicine, pharmacy and dentistry students (p<0." | 1.36 | Primary dysmenorrhea among Mexican university students: prevalence, impact and treatment. ( Ortiz, MI, 2010) |
| "Atropine did not inhibit the antinociceptive effects of both mepyramine and famotidine on formalin-induced nociception." | 1.35 | Effects of mepyramine and famotidine on the physostigmine-induced antinociception in the formalin test in rats. ( Mojtahedin, A; Tamaddonfard, E; Zanbouri, A, 2008) |
| "(AR) has been used to treat pain and inflammation in Korea." | 1.32 | Mechanism of anti-nociceptive effects of Asarum sieboldii Miq. radix: potential role of bradykinin, histamine and opioid receptor-mediated pathways. ( Gao Zhang, C; Kim, SJ; Taek Lim, J, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (10.53) | 18.2507 |
| 2000's | 12 (63.16) | 29.6817 |
| 2010's | 4 (21.05) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, H | 1 |
| Altenbach, RJ | 1 |
| Carr, TL | 1 |
| Chandran, P | 1 |
| Hsieh, GC | 1 |
| Lewis, LG | 1 |
| Manelli, AM | 1 |
| Milicic, I | 1 |
| Marsh, KC | 1 |
| Miller, TR | 1 |
| Strakhova, MI | 1 |
| Vortherms, TA | 1 |
| Wakefield, BD | 1 |
| Wetter, JM | 1 |
| Witte, DG | 1 |
| Honore, P | 1 |
| Esbenshade, TA | 1 |
| Brioni, JD | 1 |
| Cowart, MD | 1 |
| Hao, J | 1 |
| Brosse, L | 1 |
| Bonnet, C | 1 |
| Ducrocq, M | 1 |
| Padilla, F | 1 |
| Penalba, V | 1 |
| Desplat, A | 1 |
| Ruel, J | 1 |
| Delmas, P | 1 |
| Laurino, A | 1 |
| De Siena, G | 1 |
| Resta, F | 1 |
| Masi, A | 1 |
| Musilli, C | 1 |
| Zucchi, R | 1 |
| Raimondi, L | 1 |
| Fischer, L | 1 |
| Lavoranti, MI | 1 |
| de Oliveira Borges, M | 1 |
| Miksza, AF | 1 |
| Sardi, NF | 1 |
| Martynhak, BJ | 1 |
| Tambeli, CH | 2 |
| Parada, CA | 2 |
| Mojtahedin, A | 1 |
| Tamaddonfard, E | 1 |
| Zanbouri, A | 1 |
| Ortiz, MI | 1 |
| Mobarakeh, JI | 2 |
| Torkaman-Boutorabi, A | 1 |
| Rahimi, AA | 1 |
| Ghasri, S | 1 |
| Nezhad, RM | 1 |
| Hamzely, A | 1 |
| Khoshkholgh Sima, B | 1 |
| Takahashi, K | 1 |
| Nunoki, K | 1 |
| Yanai, K | 2 |
| Ashmawi, HA | 1 |
| Chambergo, FS | 1 |
| Araújo Palmeira, CC | 1 |
| Posso, IP | 1 |
| Kim, SJ | 1 |
| Gao Zhang, C | 1 |
| Taek Lim, J | 1 |
| Suzuki, R | 1 |
| Edwards, M | 1 |
| Dickenson, AH | 1 |
| Liu, T | 1 |
| Bai, ZT | 1 |
| Pang, XY | 1 |
| Chai, ZF | 1 |
| Jiang, F | 1 |
| Ji, YH | 1 |
| Tyler, BM | 1 |
| Groshan, K | 1 |
| Cusack, B | 1 |
| Richelson, E | 1 |
| Dubuc, I | 1 |
| Remande, S | 1 |
| Costentin, J | 1 |
| Sakurada, S | 1 |
| Katsuyama, S | 1 |
| Kutsuwa, M | 1 |
| Kuramasu, A | 1 |
| Lin, ZY | 1 |
| Watanabe, T | 2 |
| Hashimoto, Y | 1 |
| Harasawa, K | 1 |
| Cunha, FQ | 1 |
| Ferreira, SH | 1 |
| Olsen, UB | 1 |
| Eltorp, CT | 1 |
| Ingvardsen, BK | 1 |
| Jørgensen, TK | 1 |
| Lundbaek, JA | 1 |
| Thomsen, C | 1 |
| Hansen, AJ | 1 |
| Galeotti, N | 1 |
| Ghelardini, C | 1 |
| Bartolini, A | 1 |
| Thomsen, JS | 1 |
| Benfeldt, E | 1 |
| Jensen, SB | 1 |
| Serup, J | 1 |
| Menné, T | 1 |
1 trial available for pyrilamine and Ache
| Article | Year |
|---|---|
Topically applied aspirin decreases histamine-induced wheal and flare reactions in normal and SLS-inflamed skin, but does not decrease itch. A randomized, double-blind and placebo-controlled human study.
Topics: Administration, Topical; Adult; Analysis of Variance; Aspirin; Dermatitis, Irritant; Double-Blind Me | 2002 |
18 other studies available for pyrilamine and Ache
| Article | Year |
|---|---|
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; | 2008 |
The widely used antihistamine mepyramine causes topical pain relief through direct blockade of nociceptor sodium channels.
Topics: Action Potentials; Animals; Arthritis, Experimental; Ganglia, Spinal; Histamine H1 Antagonists; Male | 2021 |
3-iodothyroacetic acid, a metabolite of thyroid hormone, induces itch and reduces threshold to noxious and to painful heat stimuli in mice.
Topics: Animals; Ganglia, Spinal; Histamine H1 Antagonists; Histidine Decarboxylase; Hot Temperature; Male; | 2015 |
TRPA1, substance P, histamine and 5-hydroxytryptamine interact in an interdependent way to induce nociception.
Topics: Acetanilides; Animals; Histamine; Histamine H1 Antagonists; Isothiocyanates; Male; Oligonucleotides, | 2017 |
Effects of mepyramine and famotidine on the physostigmine-induced antinociception in the formalin test in rats.
Topics: Analgesics; Animals; Atropine; Drug Interactions; Famotidine; Formaldehyde; Histamine H1 Antagonists | 2008 |
Primary dysmenorrhea among Mexican university students: prevalence, impact and treatment.
Topics: Absenteeism; Acetaminophen; Adolescent; Dipyrone; Drug Combinations; Dysmenorrhea; Female; Humans; M | 2010 |
Interaction of histamine and calcitonin gene-related peptide in the formalin induced pain perception in rats.
Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antag | 2011 |
The effects of pyrilamine and cimetidine on mRNA C-fos expression and nociceptive flinching behavior in rats.
Topics: Animals; Behavior, Animal; Blotting, Northern; Cimetidine; Dose-Response Relationship, Drug; Formald | 2003 |
Mechanism of anti-nociceptive effects of Asarum sieboldii Miq. radix: potential role of bradykinin, histamine and opioid receptor-mediated pathways.
Topics: Analgesics, Non-Narcotic; Animals; Asarum; Bradykinin; Carrageenan; Edema; Guinea Pigs; Histamine; I | 2003 |
ReN-1869 [(R)-1-(3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-propyl)-3-piperidine carboxylic acid], a novel histamine H1 receptor antagonist, produces potent and selective antinociceptive effects on dorsal horn neurons after inflammation and
Topics: Analgesics; Animals; Disease Models, Animal; Electrophysiology; Histamine H1 Antagonists; Inflammati | 2004 |
Degranulation of mast cells and histamine release involved in rat pain-related behaviors and edema induced by scorpion Buthus martensi Karch venom.
Topics: Animals; Chlorpheniramine; Cimetidine; Dose-Response Relationship, Drug; Edema; Histamine Antagonist | 2007 |
In vivo studies with low doses of levocabastine and diphenhydramine, but not pyrilamine, antagonize neurotensin-mediated antinociception.
Topics: Animals; Body Temperature Regulation; Diphenhydramine; Drug Evaluation, Preclinical; Histamine H1 An | 1998 |
The partial agonist properties of levocabastine in neurotensin-induced analgesia.
Topics: Analgesia; Analgesics; Animals; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Male; Mi | 1999 |
Role of histamine H(1) receptor in pain perception: a study of the receptor gene knockout mice.
Topics: Animals; Behavior, Animal; Capsaicin; Chlorpheniramine; Formaldehyde; Histamine H1 Antagonists; Hot | 2000 |
Does the histaminergic system play a role in spinal nociception?
Topics: Animals; Dose-Response Relationship, Drug; Histamine; Histamine Agonists; Histamine Antagonists; In | 2000 |
The major role of peripheral release of histamine and 5-hydroxytryptamine in formalin-induced nociception.
Topics: Animals; Anti-Asthmatic Agents; Cimetidine; Cromolyn Sodium; Histamine; Histamine H1 Antagonists; Hi | 2001 |
ReN 1869, a novel tricyclic antihistamine, is active against neurogenic pain and inflammation.
Topics: Animals; Benzoquinones; Binding Sites; Calcitonin Gene-Related Peptide; Calcium; Calcium Channels; C | 2002 |
Antihistamine antinociception is mediated by Gi-protein activation.
Topics: Analgesics; Animals; Behavior, Animal; Central Nervous System; Diphenhydramine; Dose-Response Relati | 2002 |