pyridoxine has been researched along with Vomiting in 95 studies
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
Vomiting: The forcible expulsion of the contents of the STOMACH through the MOUTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report information about an unpublished 1970s study ("8-way" Bendectin Study) that aimed to evaluate the relative therapeutic efficacy of doxylamine, pyridoxine, and dicyclomine in the management of nausea and vomiting during pregnancy." | 9.24 | 8-Way Randomized Controlled Trial of Doxylamine, Pyridoxine and Dicyclomine for Nausea and Vomiting during Pregnancy: Restoration of Unpublished Information. ( Persaud, N; Zhang, R, 2017) |
| "Doxylamine succinate-pyridoxine hydrochloride delayed release combination is safe and well tolerated by pregnant women when used in the recommended dose of up to 4 tablets daily in treating nausea and vomiting of pregnancy." | 9.20 | Maternal safety of the delayed-release doxylamine and pyridoxine combination for nausea and vomiting of pregnancy; a randomized placebo controlled trial. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Matok, I; Mattison, DR; Miodovnik, M; Umans, JG, 2015) |
| "This was a double-blind, randomized, controlled trial in which women with nausea and vomiting of pregnancy were assigned to 4 mg of ondansetron plus a placebo tablet or 25 mg pyridoxine plus 12." | 9.19 | Ondansetron compared with doxylamine and pyridoxine for treatment of nausea in pregnancy: a randomized controlled trial. ( Capp, SM; Carstairs, SD; Oliveira, LG; Riffenburgh, RH; You, WB, 2014) |
| " The authors' objective is to identify the determinants of adherence to delayed-release doxylamine-pyridoxine (Diclectin) in patients with nausea and vomiting of pregnancy (NVP)." | 9.16 | Determinants of adherence to delayed-release doxylamine and pyridoxine in patients with nausea and vomiting of pregnancy. ( Caritis, S; Chiossi, G; Clark, S; Costantine, MM; Hankins, GD; Koren, G; Matok, I; Miodovnik, M; Umans, JG, 2012) |
| "Diclectin delayed release formulation of doxylamine succinate and pyridoxine hydrochloride is effective and well tolerated in treating nausea and vomiting of pregnancy." | 9.14 | Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Mattison, DR; Miodovnik, M; Umans, JG, 2010) |
| "There was a significant decrease in the mean of posttherapy minus baseline nausea scores in the pyridoxine compared with that in the placebo group (t test, p = 0." | 9.08 | Pyridoxine for nausea and vomiting of pregnancy: a randomized, double-blind, placebo-controlled trial. ( Ruangsri, R; Vutyavanich, T; Wongtra-ngan, S, 1995) |
| "Diclectin (pyridoxine 10 mg and doxylamine 10 mg) has traditionally been used to treat nausea and vomiting of pregnancy (NVP); however, this drug is unavailable in many countries." | 7.79 | Evaluation of the efficacy and safety of bi-daily combination therapy with pyridoxine and doxylamine for nausea and vomiting of pregnancy. ( Ashkenazi-Hoffnung, L; Klinger, G; Merlob, P; Stahl, B, 2013) |
| "A delayed-release combination of doxylamine-pyridoxine (D-P) (Diclectin) is the only approved antiemetic medication for use in pregnancy in Canada." | 7.71 | The safety of higher than standard dose of doxylamine-pyridoxine (Diclectin) for nausea and vomiting of pregnancy. ( Atanackovic, G; Koren, G; Moretti, ME; Navioz, Y, 2001) |
| "An effective and safe treatment for nausea and vomiting of pregnancy (NVP) is lacking." | 7.30 | Acupuncture and Doxylamine-Pyridoxine for Nausea and Vomiting in Pregnancy : A Randomized, Controlled, 2 ( An, CM; Cao, YJ; Chen, XY; Cong, J; Cui, YM; Feng, YH; Gao, JS; Hu, YH; Li, J; Li, L; Liu, JP; Liu, L; Liu, YX; Liu, ZL; Liu, ZS; Lu, ZL; Ma, HL; Mol, BWJ; Ng, EHY; Painter, RC; Qi, X; Qin, HC; Wang, CC; Wang, Y; Wang, YX; Wu, Q; Wu, XK; Yan, Y; Yang, XM; Yu, L; Zhang, B; Zhou, LL, 2023) |
| "We report information about an unpublished 1970s study ("8-way" Bendectin Study) that aimed to evaluate the relative therapeutic efficacy of doxylamine, pyridoxine, and dicyclomine in the management of nausea and vomiting during pregnancy." | 5.24 | 8-Way Randomized Controlled Trial of Doxylamine, Pyridoxine and Dicyclomine for Nausea and Vomiting during Pregnancy: Restoration of Unpublished Information. ( Persaud, N; Zhang, R, 2017) |
| "Doxylamine succinate-pyridoxine hydrochloride delayed release combination is safe and well tolerated by pregnant women when used in the recommended dose of up to 4 tablets daily in treating nausea and vomiting of pregnancy." | 5.20 | Maternal safety of the delayed-release doxylamine and pyridoxine combination for nausea and vomiting of pregnancy; a randomized placebo controlled trial. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Matok, I; Mattison, DR; Miodovnik, M; Umans, JG, 2015) |
| "This was a double-blind, randomized, controlled trial in which women with nausea and vomiting of pregnancy were assigned to 4 mg of ondansetron plus a placebo tablet or 25 mg pyridoxine plus 12." | 5.19 | Ondansetron compared with doxylamine and pyridoxine for treatment of nausea in pregnancy: a randomized controlled trial. ( Capp, SM; Carstairs, SD; Oliveira, LG; Riffenburgh, RH; You, WB, 2014) |
| " The authors' objective is to identify the determinants of adherence to delayed-release doxylamine-pyridoxine (Diclectin) in patients with nausea and vomiting of pregnancy (NVP)." | 5.16 | Determinants of adherence to delayed-release doxylamine and pyridoxine in patients with nausea and vomiting of pregnancy. ( Caritis, S; Chiossi, G; Clark, S; Costantine, MM; Hankins, GD; Koren, G; Matok, I; Miodovnik, M; Umans, JG, 2012) |
| "Diclectin delayed release formulation of doxylamine succinate and pyridoxine hydrochloride is effective and well tolerated in treating nausea and vomiting of pregnancy." | 5.14 | Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Mattison, DR; Miodovnik, M; Umans, JG, 2010) |
| " We used as a motivating example the possible teratogenic risks of antiemetic agents in pregnancy since a large observational study recently showed that first-trimester exposure to doxylamine-pyridoxine was associated with significantly increased risk of congenital malformations as a whole, as well as central nervous system defects, and previous observational studies did not show such associations." | 5.12 | Misleading meta-analyses of observational studies may generate unjustified alarms: The case of medications for nausea and vomiting in pregnancy. ( Biffi, A; Cetin, I; Corrao, G; Filippelli, A; Locatelli, A; Rea, F, 2021) |
| "Combination therapy with pyridoxine and metoclopramide appears to be superior to either monotherapy in the treatment of nausea and vomiting in pregnancy." | 5.10 | Comparison of three outpatient regimens in the management of nausea and vomiting in pregnancy. ( Bsat, FA; Hoffman, DE; Seubert, DE, 2003) |
| "There was a significant decrease in the mean of posttherapy minus baseline nausea scores in the pyridoxine compared with that in the placebo group (t test, p = 0." | 5.08 | Pyridoxine for nausea and vomiting of pregnancy: a randomized, double-blind, placebo-controlled trial. ( Ruangsri, R; Vutyavanich, T; Wongtra-ngan, S, 1995) |
| "Fifty-nine women completed a randomized, double-blind placebo-controlled study of pyridoxine hydrochloride (vitamin B6) for the treatment of nausea and vomiting of pregnancy." | 5.07 | Vitamin B6 is effective therapy for nausea and vomiting of pregnancy: a randomized, double-blind placebo-controlled study. ( Niebyl, J; Rose, N; Rouse, D; Sahakian, V; Sipes, S, 1991) |
| "A double-blind comparison was undertaken between Debendox with 10mg of extra pyridoxine and placebo with 10mg of pyridoxine, in 56 women suffering from nausea and/or vomiting during the first 10 weeks of pregnancy." | 5.04 | Treatment of pregnancy sickness. ( Wheatley, D, 1977) |
| "For mild symptoms of nausea and emesis of pregnancy, ginger, pyridoxine, antihistamines, and metoclopramide were associated with greater benefit than placebo." | 4.93 | Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review. ( Beyer, F; Bradley, J; Bryant, A; McParlin, C; Moloney, E; Muirhead, CR; Nelson-Piercy, C; Newbury-Birch, D; Norman, J; O'Donnell, A; Robson, SC; Shaw, C; Simpson, E; Swallow, B; Vale, L; Yates, L, 2016) |
| "Ten randomized trials studying the effects of acupressure, ginger, and pyridoxine on nausea and vomiting of pregnancy were reviewed." | 4.80 | Alternative therapies for nausea and vomiting of pregnancy. ( Aikins Murphy, P, 1998) |
| "Using the Quebec Pregnancy Cohort (1998-2015), first-trimester doxylamine-pyridoxine, metoclopramide, and ondansetron exposures were assessed for their association with MCM." | 3.91 | New evidence for concern over the risk of birth defects from medications for nausea and vomitting of pregnancy. ( Bérard, A; Bernatsky, S; Gorgui, J; Sheehy, O; Soares de Moura, C; Zhao, JP, 2019) |
| "Diclectin (pyridoxine 10 mg and doxylamine 10 mg) has traditionally been used to treat nausea and vomiting of pregnancy (NVP); however, this drug is unavailable in many countries." | 3.79 | Evaluation of the efficacy and safety of bi-daily combination therapy with pyridoxine and doxylamine for nausea and vomiting of pregnancy. ( Ashkenazi-Hoffnung, L; Klinger, G; Merlob, P; Stahl, B, 2013) |
| "Diclectin, composed of 10 mg doxylamine succinate (DOX) and 10 mg pyridoxine hydrochloride, is the drug combination of choice for the management of nausea and vomiting during pregnancy in Canada." | 3.77 | Systemic bioavailability and pharmacokinetics of the doxylamine-pyridoxine delayed-release combination (Diclectin). ( Garcia-Bournissen, F; Gill, SK; Koren, G, 2011) |
| "Women who called the Motherisk NVP helpline, and were taking only Diclectin (vitamin B6 10 mg and doxylamine 10 mg), were enrolled in the study and assessed for the severity of nausea and vomiting of pregnancy (NVP) with the Motherisk-PUQE (pregnancy-unique quantification of emesis and nausea) scoring system." | 3.72 | Diclectin therapy for nausea and vomiting of pregnancy: effects of optimal dosing. ( Boskovic, R; Einarson, A; Koren, G; Maltepe, C; Wolpin, J, 2003) |
| "A delayed-release combination of doxylamine-pyridoxine (D-P) (Diclectin) is the only approved antiemetic medication for use in pregnancy in Canada." | 3.71 | The safety of higher than standard dose of doxylamine-pyridoxine (Diclectin) for nausea and vomiting of pregnancy. ( Atanackovic, G; Koren, G; Moretti, ME; Navioz, Y, 2001) |
| "Several controlled trials show the efficacy of prednisone for nausea and vomiting of pregnancy (NVP), but your case is fascinating in proving the point by challenge-rechallenge." | 3.70 | Managing women with nausea and vomiting of pregnancy. Canadian consensus. ( , 2000) |
| "The author summarizes the theoretical aspects of vomiting and alleviation of the same by surveying the respective scientific communications with special regard to thiethylperazine." | 3.68 | Torecan, a review of references and clinical control examinations. ( Rádi, A, 1990) |
| "Acute isoniazid intoxication is characterised by high mortality and vomiting, seizures, coma and metabolic acidosis as main symptoms." | 3.67 | [Acute isoniazid poisoning]. ( Bode, U; Köster, B; Musch, E; Weber, HP, 1985) |
| "An effective and safe treatment for nausea and vomiting of pregnancy (NVP) is lacking." | 3.30 | Acupuncture and Doxylamine-Pyridoxine for Nausea and Vomiting in Pregnancy : A Randomized, Controlled, 2 ( An, CM; Cao, YJ; Chen, XY; Cong, J; Cui, YM; Feng, YH; Gao, JS; Hu, YH; Li, J; Li, L; Liu, JP; Liu, L; Liu, YX; Liu, ZL; Liu, ZS; Lu, ZL; Ma, HL; Mol, BWJ; Ng, EHY; Painter, RC; Qi, X; Qin, HC; Wang, CC; Wang, Y; Wang, YX; Wu, Q; Wu, XK; Yan, Y; Yang, XM; Yu, L; Zhang, B; Zhou, LL, 2023) |
| "Nausea and vomiting are common in early pregnancy." | 2.50 | The pharmacologic management of nausea and vomiting of pregnancy. ( Briggs, GG; Niebyl, JR, 2014) |
| "Nausea and vomiting affects a large proportion of women in early pregnancy, yet because it is a physiological symptom it is often dismissed by health professionals, leaving women to find their own coping mechanisms." | 2.41 | Nausea and vomiting in pregnancy: safety and efficacy of self-administered complementary therapies. ( Tiran, D, 2002) |
| " Pyridoxine is considered safe for use during pregnancy, but its efficacy in treating nausea and vomiting has not been determined." | 2.37 | Safety and efficacy of antiemetics used to treat nausea and vomiting in pregnancy. ( Leathem, AM, 1986) |
| " Thus, in France, as in other countries, vitamin B6 could be integrated into the therapeutic arsenal of mild to moderate nausea and vomiting during pregnancy according to the following dosage schedule: oral intake of 10mg four times a day of a compounded preparation of vitamin B6, alone or in combination with doxylamine." | 1.56 | [Interest of vitamin b6 for treatment of nausea and/or vomiting during pregnancy]. ( Pecriaux, C, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 50 (52.63) | 18.7374 |
| 1990's | 7 (7.37) | 18.2507 |
| 2000's | 15 (15.79) | 29.6817 |
| 2010's | 16 (16.84) | 24.3611 |
| 2020's | 7 (7.37) | 2.80 |
| Authors | Studies |
|---|---|
| Schrager, NL | 1 |
| Parker, SE | 1 |
| Werler, MM | 1 |
| Jayawardena, R | 1 |
| Majeed, S | 1 |
| Sooriyaarachchi, P | 1 |
| Abeywarne, U | 1 |
| Ranaweera, P | 1 |
| Saz-Leal, P | 1 |
| Zamorano-Domínguez, L | 1 |
| Frías, J | 1 |
| Guerra, P | 1 |
| Saura-Valls, M | 1 |
| Roca-Juanes, R | 1 |
| Nebot-Troyano, J | 1 |
| García-Aguilar, E | 1 |
| Vilchez, T | 1 |
| Urso, K | 1 |
| Wu, XK | 1 |
| Gao, JS | 1 |
| Ma, HL | 1 |
| Wang, Y | 1 |
| Zhang, B | 1 |
| Liu, ZL | 1 |
| Li, J | 1 |
| Cong, J | 1 |
| Qin, HC | 1 |
| Yang, XM | 1 |
| Wu, Q | 1 |
| Chen, XY | 1 |
| Lu, ZL | 1 |
| Feng, YH | 1 |
| Qi, X | 1 |
| Wang, YX | 1 |
| Yu, L | 1 |
| Cui, YM | 1 |
| An, CM | 1 |
| Zhou, LL | 1 |
| Hu, YH | 1 |
| Li, L | 1 |
| Cao, YJ | 1 |
| Yan, Y | 1 |
| Liu, L | 1 |
| Liu, YX | 1 |
| Liu, ZS | 1 |
| Painter, RC | 1 |
| Ng, EHY | 1 |
| Liu, JP | 1 |
| Mol, BWJ | 1 |
| Wang, CC | 1 |
| Azuma, F | 1 |
| Nokura, K | 1 |
| Kako, T | 1 |
| Kobayashi, D | 1 |
| Yoshimura, T | 1 |
| Wada, K | 1 |
| Pecriaux, C | 1 |
| Biffi, A | 1 |
| Rea, F | 1 |
| Locatelli, A | 1 |
| Cetin, I | 1 |
| Filippelli, A | 1 |
| Corrao, G | 1 |
| Abbas, AM | 1 |
| Bérard, A | 1 |
| Sheehy, O | 1 |
| Gorgui, J | 1 |
| Zhao, JP | 1 |
| Soares de Moura, C | 1 |
| Bernatsky, S | 1 |
| Ashkenazi-Hoffnung, L | 1 |
| Merlob, P | 1 |
| Stahl, B | 1 |
| Klinger, G | 1 |
| Niebyl, JR | 1 |
| Briggs, GG | 1 |
| GOLDBLAT, A | 1 |
| Madjunkova, S | 1 |
| Maltepe, C | 3 |
| Koren, G | 12 |
| Festin, M | 1 |
| Oliveira, LG | 1 |
| Capp, SM | 1 |
| You, WB | 1 |
| Riffenburgh, RH | 1 |
| Carstairs, SD | 1 |
| Clark, S | 3 |
| Hankins, GD | 3 |
| Caritis, SN | 2 |
| Umans, JG | 3 |
| Miodovnik, M | 3 |
| Mattison, DR | 2 |
| Matok, I | 2 |
| Faramarzi, M | 1 |
| Yazdani, S | 1 |
| Barat, S | 1 |
| McParlin, C | 1 |
| O'Donnell, A | 1 |
| Robson, SC | 1 |
| Beyer, F | 1 |
| Moloney, E | 1 |
| Bryant, A | 1 |
| Bradley, J | 1 |
| Muirhead, CR | 1 |
| Nelson-Piercy, C | 1 |
| Newbury-Birch, D | 1 |
| Norman, J | 1 |
| Shaw, C | 1 |
| Simpson, E | 1 |
| Swallow, B | 1 |
| Yates, L | 1 |
| Vale, L | 1 |
| Zhang, R | 1 |
| Persaud, N | 1 |
| Nulman, I | 1 |
| Rovet, J | 1 |
| Barrera, M | 1 |
| Knittel-Keren, D | 1 |
| Feldman, BM | 1 |
| DIXON, J | 1 |
| ROGANTI, A | 1 |
| CUNEO, JC | 1 |
| BERGMANN, W | 1 |
| HESSELTINE, HC | 1 |
| Gill, SK | 1 |
| Garcia-Bournissen, F | 2 |
| Costantine, MM | 1 |
| Chiossi, G | 1 |
| Caritis, S | 1 |
| Arsenault, MY | 1 |
| Lane, CA | 1 |
| MacKinnon, CJ | 1 |
| Bartellas, E | 1 |
| Cargill, YM | 1 |
| Klein, MC | 1 |
| Martel, MJ | 1 |
| Sprague, AE | 1 |
| Wilson, AK | 1 |
| Tiran, D | 1 |
| Brent, R | 2 |
| Kutcher, JS | 1 |
| Engle, A | 1 |
| Firth, J | 1 |
| Lamm, SH | 1 |
| BALESTRI, F | 1 |
| WEDEL, KW | 1 |
| MONIAS, M | 1 |
| TOWNE, JE | 1 |
| TONSO, C | 1 |
| SHLIAKHTINA, ON | 1 |
| BENTLEY, MD | 1 |
| BETHEA, RC | 1 |
| DAVIDSON, OL | 1 |
| GEIGER, CJ | 1 |
| FAHRENBACH, DM | 1 |
| HEALEY, FJ | 1 |
| ALEXANDER, CH | 1 |
| DIGGORY, PL | 1 |
| TOMKINSON, JS | 1 |
| RHODES, P | 1 |
| ROSENVASSER, EB | 1 |
| CARPANO, A | 1 |
| WOODHULL, RB | 1 |
| COLOMBINO, C | 1 |
| Boskovic, R | 1 |
| Einarson, A | 2 |
| Wolpin, J | 1 |
| Bsat, FA | 1 |
| Hoffman, DE | 1 |
| Seubert, DE | 1 |
| HILL, FW | 1 |
| JOHANNY, R | 1 |
| DORSEY, CW | 1 |
| KERNIS, L | 1 |
| STODSKY, B | 1 |
| DOMOKOS, J | 1 |
| KELEMEN, E | 1 |
| MULLA, NP | 1 |
| Staroselsky, A | 1 |
| Di Paolo, N | 1 |
| De Mia, M | 1 |
| Gaggiotti, E | 1 |
| Huff, PS | 1 |
| David, TJ | 1 |
| Mitchell, AA | 1 |
| Rosenberg, L | 1 |
| Shapiro, S | 1 |
| Slone, D | 1 |
| Harron, DW | 1 |
| Griffiths, K | 1 |
| Shanks, RG | 1 |
| Vutyavanich, T | 1 |
| Wongtra-ngan, S | 1 |
| Ruangsri, R | 1 |
| Erick, M | 1 |
| Aikins Murphy, P | 1 |
| Mahajan, MK | 1 |
| Singh, V | 1 |
| Emelianova, S | 1 |
| Mazzotta, P | 2 |
| Navioz, Y | 2 |
| Magee, LA | 1 |
| Atanackovic, G | 1 |
| Moretti, ME | 1 |
| Strong, TH | 1 |
| Allen, R | 1 |
| Wheatley, D | 1 |
| Check, WA | 1 |
| Sahakian, V | 1 |
| Rouse, D | 1 |
| Sipes, S | 1 |
| Rose, N | 1 |
| Niebyl, J | 1 |
| Rádi, A | 1 |
| Shiono, PH | 1 |
| Klebanoff, MA | 1 |
| Boehnert, MT | 1 |
| Lewander, WJ | 1 |
| Gaudreault, P | 1 |
| Lovejoy, FH | 1 |
| Leathem, AM | 1 |
| Walters, WA | 1 |
| Köster, B | 1 |
| Bode, U | 1 |
| Weber, HP | 1 |
| Musch, E | 1 |
| Elbourne, D | 1 |
| Mutch, L | 1 |
| Dauncey, M | 1 |
| Campbell, H | 1 |
| Samphier, M | 1 |
| Nagi, NA | 1 |
| Yassin, AK | 1 |
| Lipman, IJ | 1 |
| McGuinness, BW | 1 |
| Binns, DT | 1 |
| Holt, JA | 1 |
| Bortoletto, S | 1 |
| Sicher, K | 1 |
| Backhouse, TW | 1 |
| Egli, F | 1 |
| de Nève, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prevalence and Burden of Nausea and Vomiting in Pregnant Women in Switzerland: Survey Purity 2022[NCT06055192] | 200 participants (Anticipated) | Observational | 2023-09-30 | Not yet recruiting | |||
| Is Zofran Superior to Pyridoxine at Reducing Nausea and Vomiting in Pregnancy[NCT01668069] | 36 participants (Actual) | Interventional | 2012-10-31 | Completed | |||
| A Double-Blind, Multicenter, Randomized, Placebo-Controlled Trial Of The Efficacy Of Diclectin® For Nausea And Vomiting Of Pregnancy[NCT00614445] | Phase 3 | 280 participants (Actual) | Interventional | 2008-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The objective of this double-blind, randomized, placebo-controlled study was to assess the efficacy, safety, and tolerability of oral Diclectin® in the treatment of nausea and vomiting of pregnancy (NVP) as measured by the Pregnancy Unique-Quantification of Emesis (PUQE) overall score of symptoms from baseline (Day 1) to end of study visit (Day 15). The PUQE score measured hours of nausea, number of times vomiting, and number of times retching for a TOTAL overall score of symptoms on a scale rated from 3 (no symptoms) to 15 (most severe). (NCT00614445)
Timeframe: Baseline (Day 1) to End of Study Visit Day 15 (± 1 day)
| Intervention | PUQE Score (Mean) |
|---|---|
| Diclectin® | -4.8 |
| Placebo | -3.9 |
16 reviews available for pyridoxine and Vomiting
| Article | Year |
|---|---|
The effects of pyridoxine (vitamin B6) supplementation in nausea and vomiting during pregnancy: a systematic review and meta-analysis.
Topics: Antiemetics; Dietary Supplements; Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyrido | 2023 |
Misleading meta-analyses of observational studies may generate unjustified alarms: The case of medications for nausea and vomiting in pregnancy.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 2021 |
Doxylamine/pyridoxine for nausea and vomiting in pregnancy.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Practice Guidelines | 2019 |
The pharmacologic management of nausea and vomiting of pregnancy.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Histamine H1 Antagonists; Humans; N | 2014 |
The delayed-release combination of doxylamine and pyridoxine (Diclegis®/Diclectin ®) for the treatment of nausea and vomiting of pregnancy.
Topics: Antiemetics; Delayed-Action Preparations; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 2014 |
Nausea and vomiting in early pregnancy.
Topics: Acupressure; Acupuncture Therapy; Adrenal Cortex Hormones; Antiemetics; Female; Humans; Nausea; Preg | 2014 |
Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review.
Topics: Acupuncture; Adrenal Cortex Hormones; Antiemetics; Doxylamine; Female; Histamine Antagonists; Humans | 2016 |
Nausea and vomiting in pregnancy: safety and efficacy of self-administered complementary therapies.
Topics: Acupressure; Acupuncture Therapy; Attitude to Health; Complementary Therapies; Female; Humans; Mater | 2002 |
Safety of drug therapy for nausea and vomiting of pregnancy.
Topics: Abnormalities, Drug-Induced; Antiemetics; Child; Dicyclomine; Doxylamine; Drug Combinations; Female; | 1980 |
Alternative therapies for nausea and vomiting of pregnancy.
Topics: Acupressure; Complementary Therapies; Female; Humans; Nausea; Phytotherapy; Pregnancy; Pyridoxine; V | 1998 |
Alternative therapies of morning sickness.
Topics: Acupressure; Antiemetics; Complementary Therapies; Dicyclomine; Doxylamine; Drug Combinations; Femal | 2001 |
Medical, social, and legal implications of treating nausea and vomiting of pregnancy.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 2002 |
Are we failing women? Advice for nausea and vomiting in pregnancy.
Topics: Acupressure; Causality; Female; Humans; Maternal-Child Nursing; Nausea; Nurse Midwives; Nurse's Role | 2001 |
Advances in clinical toxicology.
Topics: Antidotes; Cathartics; Charcoal; Child; Cocaine; Deglutition; Foreign Bodies; Gastric Lavage; Humans | 1985 |
Safety and efficacy of antiemetics used to treat nausea and vomiting in pregnancy.
Topics: Antiemetics; Antipsychotic Agents; Dicyclomine; Diphenhydramine; Doxylamine; Drug Combinations; Fema | 1986 |
L-dopa therapy in Parkinson's disease.
Topics: Delirium; Depression; Dihydroxyphenylalanine; Gastrointestinal Hemorrhage; Hallucinations; Humans; H | 1971 |
14 trials available for pyridoxine and Vomiting
| Article | Year |
|---|---|
Acupuncture and Doxylamine-Pyridoxine for Nausea and Vomiting in Pregnancy : A Randomized, Controlled, 2
Topics: Acupuncture Therapy; Antiemetics; Child; Doxylamine; Female; Humans; Nausea; Pregnancy; Pregnancy Co | 2023 |
Ondansetron compared with doxylamine and pyridoxine for treatment of nausea in pregnancy: a randomized controlled trial.
Topics: Adult; Antiemetics; Double-Blind Method; Doxylamine; Drug Therapy, Combination; Female; Follow-Up St | 2014 |
Maternal safety of the delayed-release doxylamine and pyridoxine combination for nausea and vomiting of pregnancy; a randomized placebo controlled trial.
Topics: Adult; Antiemetics; Delayed-Action Preparations; Dicyclomine; Double-Blind Method; Doxylamine; Drug | 2015 |
A RCT of psychotherapy in women with nausea and vomiting of pregnancy.
Topics: Adolescent; Adult; Cognitive Behavioral Therapy; Combined Modality Therapy; Female; Humans; Mindfuln | 2015 |
8-Way Randomized Controlled Trial of Doxylamine, Pyridoxine and Dicyclomine for Nausea and Vomiting during Pregnancy: Restoration of Unpublished Information.
Topics: Cooperative Behavior; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Physicians | 2017 |
Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
Topics: Adult; Delayed-Action Preparations; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Meth | 2010 |
Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
Topics: Adult; Delayed-Action Preparations; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Meth | 2010 |
Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
Topics: Adult; Delayed-Action Preparations; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Meth | 2010 |
Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
Topics: Adult; Delayed-Action Preparations; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Meth | 2010 |
Determinants of adherence to delayed-release doxylamine and pyridoxine in patients with nausea and vomiting of pregnancy.
Topics: Adult; Antiemetics; Cohort Studies; Delayed-Action Preparations; Dicyclomine; Double-Blind Method; D | 2012 |
Comparison of three outpatient regimens in the management of nausea and vomiting in pregnancy.
Topics: Adult; Antiemetics; Drug Therapy, Combination; Female; Humans; Hyperemesis Gravidarum; Metoclopramid | 2003 |
Pyridoxine for nausea and vomiting of pregnancy: a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Antiemetics; Double-Blind Method; Female; Humans; Nausea; Placebos; Pregnancy; Pregnancy Comp | 1995 |
Assessment of efficacy of pyridoxine in control of radiation induced sickness.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chemotherapy, Adjuvant; Child; Child, Preschool; Delayed | 1998 |
Treatment of pregnancy sickness.
Topics: Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Dicyclomine; Double-Blind Method; Doxylamine; | 1977 |
Vitamin B6 is effective therapy for nausea and vomiting of pregnancy: a randomized, double-blind placebo-controlled study.
Topics: Adult; Double-Blind Method; Female; Humans; Nausea; Odds Ratio; Pregnancy; Pregnancy Complications; | 1991 |
'Debendox' in pregnancy sickness.
Topics: Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Female; Humans; Nausea; Parasympatholytics; P | 1971 |
An assessment of thiethylperazine (Torecan) in the control of radiation-induced nausea and vomiting.
Topics: Antiemetics; Humans; Nausea; Neoplasms; Pyridoxine; Radiotherapy; Thiethylperazine; Vomiting | 1968 |
65 other studies available for pyridoxine and Vomiting
| Article | Year |
|---|---|
The association of nausea and vomiting of pregnancy, its treatments, and select birth defects: Findings from the National Birth Defect Prevention Study.
Topics: Cleft Palate; Craniosynostoses; Female; Humans; Microphthalmos; Nausea; Pregnancy; Pregnancy Complic | 2023 |
Bioavailability of Cariban
Topics: Adult; Antiemetics; Biological Availability; Capsules; Delayed-Action Preparations; Doxylamine; Drug | 2023 |
An Adult Case of Generalized Convulsions Caused by the Ingestion of Ginkgo biloba Seeds with Alcohol.
Topics: Alcoholic Beverages; Epilepsy, Tonic-Clonic; Female; Ginkgo biloba; Humans; Middle Aged; Pyridoxal P | 2020 |
[Interest of vitamin b6 for treatment of nausea and/or vomiting during pregnancy].
Topics: Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Vitamin B 6; Vomiting | 2020 |
Is ginger really effective for the treatment of the first trimester nausea and vomiting?
Topics: Female; Humans; Nausea; Pregnancy; Pregnancy Trimester, First; Pyridoxine; Vitamin B 6; Vomiting; Zi | 2019 |
New evidence for concern over the risk of birth defects from medications for nausea and vomitting of pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Antiemetics; Cohort Studies; Dicyclomine; Doxylamine; Drug Combi | 2019 |
Evaluation of the efficacy and safety of bi-daily combination therapy with pyridoxine and doxylamine for nausea and vomiting of pregnancy.
Topics: Administration, Oral; Adult; Antiemetics; Case-Control Studies; Dicyclomine; Dose-Response Relations | 2013 |
Diclegis for nausea and vomiting of pregnancy.
Topics: Antiemetics; Delayed-Action Preparations; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 2013 |
[Action of pyridoxine in post-operative vomiting].
Topics: Humans; Postoperative Nausea and Vomiting; Pyridoxine; Vomiting | 1950 |
Long-term neurodevelopment of children exposed to maternal nausea and vomiting of pregnancy and diclectin.
Topics: Adult; Antiemetics; Child; Child Development; Child, Preschool; Cohort Studies; Dicyclomine; Doxylam | 2009 |
Pyridoxine hydrochloride (vitamin B) in emesis and hyperemesis gravidica.
Topics: Female; Humans; Pregnancy; Pregnancy Complications; Pyridoxine; Vomiting | 1946 |
Relief of postanaesthetic vomiting through pyridoxine.
Topics: Anesthesia; Humans; Iatrogenic Disease; Pyridoxine; Vomiting | 1947 |
FAILURE of pyridoxine therapy in nausea and vomiting of pregnancy.
Topics: Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Vomiting | 1946 |
Pyridoxine failure in nausea and vomiting of pregnancy.
Topics: Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Vomiting | 1946 |
Systemic bioavailability and pharmacokinetics of the doxylamine-pyridoxine delayed-release combination (Diclectin).
Topics: Adult; Antiemetics; Biological Availability; Canada; Delayed-Action Preparations; Dicyclomine; Doxyl | 2011 |
The management of nausea and vomiting of pregnancy.
Topics: Algorithms; Anti-Inflammatory Agents; Antiemetics; Complementary Therapies; Cost of Illness; Decisio | 2002 |
Bendectin and birth defects: hopefully, the final chapter.
Topics: Abnormalities, Drug-Induced; Adult; Adverse Drug Reaction Reporting Systems; Animals; Antiemetics; C | 2003 |
Bendectin and birth defects. II: Ecological analyses.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Adverse Drug Reaction Reporting Systems | 2003 |
[Treatment of hyperemesis gravidarum with combined inositol and pyridoxine].
Topics: Female; Humans; Hyperemesis Gravidarum; Inositol; Pregnancy; Pregnancy Complications; Pyridoxine; Vi | 1955 |
[Use of pyridoxin in postanesthetic vomiting].
Topics: Anesthesia; Pyridoxine; Vitamin B 6; Vomiting | 1955 |
Evaluation of cyclizine with pyridoxine in vomiting of pregnancy.
Topics: Cyclizine; Female; Histamine H1 Antagonists; Pregnancy; Pregnancy Complications; Pyridoxine; Vitamin | 1957 |
Nausea and vomiting of pregnancy: treatment with bendectin.
Topics: Dicyclomine; Doxylamine; Drug Combinations; Histamine H1 Antagonists; Muscle Relaxants, Central; Nau | 1958 |
[Synergism of action between chlorpromazine, chlortrimeton, banthine, beta-phenylisopropylamine & pyridoxine].
Topics: Acetylcholine; Amines; Amphetamine; Amphetamines; Chlorpheniramine; Chlorpromazine; Cholinergic Anta | 1959 |
[Pyridoxine therapy of vomiting in pregnancy].
Topics: Female; Pregnancy; Pregnancy Complications; Pyridoxine; Vitamin B 6; Vomiting | 1959 |
Adjunctive use of meclizine-pyridoxine (bonadoxin) in the prevention of preoperative and postoperative nausea and emesis.
Topics: Anti-Allergic Agents; Dental Care; Histamine H1 Antagonists; Humans; Meclizine; Postoperative Nausea | 1959 |
Evaluation of a combination of meclizine and pyridoxine in the control of nausea and vomiting in pregnancy.
Topics: Anti-Allergic Agents; Female; Histamine H1 Antagonists; Humans; Hyperemesis Gravidarum; Meclizine; N | 1960 |
Clinical experience with a combination of trimethobenzamide and pyridoxine in patients with nausea and vomiting of pregnancy.
Topics: Antiemetics; Benzamides; Female; Humans; Hyperemesis Gravidarum; Nausea; Pregnancy; Pregnancy Compli | 1960 |
Bendectin in the treatment of nausea and vomiting in pregnancy.
Topics: Dicyclomine; Doxylamine; Drug Combinations; Histamine H1 Antagonists; Muscle Relaxants, Central; Nau | 1959 |
Control of nausea and vomiting of pregnancy with rimethobenzamide and pyridoxine.
Topics: Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Vitamin B 6; Vomiting | 1962 |
Nausea and vomiting in pregnancy. A trial of meclozine dihydrochloride with and without pyridoxine.
Topics: Antiemetics; Female; Humans; Hyperemesis Gravidarum; Meclizine; Nausea; Pregnancy; Pyridoxine; Vomit | 1962 |
HYPEREMESIS GRAVIDARUM.
Topics: Blood Chemical Analysis; Female; Humans; Hyperemesis Gravidarum; Meclizine; Nausea; Pathology; Pregn | 1964 |
[FAINTING AND NAUSEA OF PREGNANCY. ITS THERAPY WITH A COMBINATION OF A NEW POORLY SOLUBLE SALT OF DIPHENHYDRAMINE, SCOPOLAMINE AND PYRIDOXINE].
Topics: Diphenhydramine; Female; Humans; Hyperemesis Gravidarum; Nausea; Pharmacology; Pregnancy; Pyridoxine | 1963 |
AN EFFECTIVE CONTROL OF NAUSEA AND VOMITING IN PREGNANCY.
Topics: Drug Therapy; Female; Humans; Nausea; Pregnancy; Pyridoxine; Toxicology; Vomiting | 1965 |
[Adrenal cortex hormones and pyridoxine in therapy of hyperemesis gravidarum].
Topics: Adrenal Cortex; Adrenal Cortex Hormones; Female; Hyperemesis Gravidarum; Pregnancy; Pregnancy Compli | 1955 |
Diclectin therapy for nausea and vomiting of pregnancy: effects of optimal dosing.
Topics: Adult; Antiemetics; Dose-Response Relationship, Drug; Doxylamine; Drug Combinations; Female; Humans; | 2003 |
Pyridoxine in the treatment of postanaesthetic nausea and vomiting.
Topics: Humans; Nausea; Pyridoxine; Vomiting | 1951 |
[Prevention of postanesthetic vomiting due to ether with pyridoxine].
Topics: Biomedical Research; Ether; Ethers; Humans; Pyridoxine; Vitamin B 6; Vomiting | 1951 |
The use of pyridoxine and suprarenal cortex combined in the treatment of nausea and vomiting of pregnancy.
Topics: Female; Folic Acid; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Vitamin B Comple | 1949 |
Failure of pyridoxine in post anesthetic nausea and vomiting.
Topics: Anesthesia; Anesthetics; Humans; Nausea; Pyridoxine; Vitamin B 6; Vomiting | 1950 |
[Clinical and animal experiments on the prevention of vomiting and of bone marrow damage due to nitrogen mustard by the use of pyridoxine and choline, respectively].
Topics: Animal Experimentation; Animals; Biomedical Research; Bone Marrow; Choline; Humans; Mechlorethamine; | 1950 |
EVALUATION OF TRIMETHOBENZAMIDE WITH PYRIDOXINE IN NAUSEA AND VOMITING OF PREGNANCY.
Topics: Benzamides; Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Vomiting | 1963 |
American Gastroenterological Association institute medical position statement on the use of gastrointestinal medication in pregnancy.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Gastrointestinal Agents; Gastrointe | 2007 |
[Metadoxine in the treatment of vomiting in uremic patients under dialysis treatment].
Topics: Adolescent; Adult; Aged; Domperidone; Drug Combinations; Humans; Middle Aged; Pyridoxine; Pyrrolidin | 1984 |
Debendox does not cause the Poland anomaly.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Antiemetics; Dicyclomine; Doxylamine; Drug Com | 1982 |
Birth defects related to bendectin use in pregnancy. I. Oral clefts and cardiac defects.
Topics: Antiemetics; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Drug Combinations; Drug Evaluation; F | 1981 |
Debendox and congenital malformations in Northern Ireland.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug | 1980 |
Vitamin B-6 and ginger in morning sickness.
Topics: Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Spices; Vomiting | 1995 |
Prevalence and severity of nausea and vomiting of pregnancy and effect of vitamin supplementation.
Topics: Canada; Dietary Supplements; Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Prevalence; | 1999 |
Managing women with nausea and vomiting of pregnancy. Canadian consensus.
Topics: Adult; Anti-Inflammatory Agents; Antiemetics; Asthma; Diagnosis, Differential; Doxylamine; Drug Ther | 2000 |
Attitudes, management and consequences of nausea and vomiting of pregnancy in the United States and Canada.
Topics: Adult; Antiemetics; Attitude; Attitude of Health Personnel; Canada; Cost of Illness; Dicyclomine; Di | 2000 |
Appraisal of drug therapy for nausea and vomiting of pregnancy: I. The placebo effect - methodological and practical considerations.
Topics: Female; Humans; Nausea; Placebo Effect; Pregnancy; Pregnancy Complications; Pyridoxine; Randomized C | 2000 |
The safety of higher than standard dose of doxylamine-pyridoxine (Diclectin) for nausea and vomiting of pregnancy.
Topics: Antiemetics; Doxylamine; Drug Combinations; Female; Humans; Infant, Newborn; Nausea; Pregnancy; Preg | 2001 |
CDC study: no evidence for teratogenicity of Bendectin.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Heart | 1979 |
Torecan, a review of references and clinical control examinations.
Topics: Adolescent; Child; Drug Evaluation; Female; Humans; Male; Nausea; Pregnancy; Pyridoxine; Thiethylper | 1990 |
Bendectin and human congenital malformations.
Topics: Abnormalities, Drug-Induced; Central Nervous System; Dicyclomine; Digestive System Abnormalities; Do | 1989 |
The management of nausea and vomiting during pregnancy.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Legislation, Drug; Nausea; | 1987 |
[Acute isoniazid poisoning].
Topics: Acidosis; Coma; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Infant; Isoniazid; Metab | 1985 |
Debendox revisited.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Drug Com | 1985 |
L-dopa. II.
Topics: Anorexia Nervosa; Cardiac Complexes, Premature; Dihydroxyphenylalanine; Drug Synergism; Humans; Hypo | 1970 |
Organic mercury poisoning in children.
Topics: Ataxia; Child; Diet; Dimercaprol; Edetic Acid; Female; Fungicides, Industrial; Hemoglobins; Humans; | 1974 |
A trial of thiethylperazine ("Torecan") in patients suffering from radiation sickness.
Topics: Dimenhydrinate; Feeding and Eating Disorders; Humans; Nausea; Neoplasms; Pyridoxine; Radiation Injur | 1965 |
[Evaluation of a combination of antiemetics in cases of nausea and vomiting during pregnancy].
Topics: Adolescent; Adult; Antiemetics; Cyclohexanecarboxylic Acids; Female; Humans; Nausea; Pre-Eclampsia; | 1968 |
Vitamins of the B complex.
Topics: Aged; Alcoholism; Anemia, Hypochromic; Avitaminosis; Beriberi; Heart Failure; Humans; Isoniazid; Ner | 1968 |
[Treatment of vomiting in infants and children with itinerol B6].
Topics: Antiemetics; Child; Child, Preschool; Humans; Infant; Pyridoxine; Vomiting | 1966 |
[Post anesthetic vomiting and vitamin B 6 prophylaxis].
Topics: Adolescent; Adult; Aged; Anesthesia; Child; Child, Preschool; Female; Humans; Male; Middle Aged; Pyr | 1966 |