pyridoxine has been researched along with Thrombophilia in 9 studies
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
Thrombophilia: A disorder of HEMOSTASIS in which there is a tendency for the occurrence of THROMBOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The Vitamins and Thrombosis (VITRO) study investigated the effect of homocysteine lowering by daily supplementation of B vitamins on the risk reduction of deep vein thrombosis (DVT) and pulmonary embolism (PE)." | 9.12 | Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: A randomized, placebo-controlled, double-blind trial. ( Blom, HJ; Bos, GM; Cattaneo, M; den Heijer, M; Eichinger, S; Gerrits, WB; Rosendaal, FR; Willems, HP, 2007) |
| "Homocystinuria (HCU) due to cystathionine beta-synthase (CBS) deficiency leads to severe hyperhomocysteinemia (HHcy)." | 8.80 | Vascular complications of severe hyperhomocysteinemia in patients with homocystinuria due to cystathionine beta-synthase deficiency: effects of homocysteine-lowering therapy. ( Boers, GH; Naughten, ER; Wilcken, B; Wilcken, DE; Yap, S, 2000) |
| "The Vitamins and Thrombosis (VITRO) study investigated the effect of homocysteine lowering by daily supplementation of B vitamins on the risk reduction of deep vein thrombosis (DVT) and pulmonary embolism (PE)." | 5.12 | Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: A randomized, placebo-controlled, double-blind trial. ( Blom, HJ; Bos, GM; Cattaneo, M; den Heijer, M; Eichinger, S; Gerrits, WB; Rosendaal, FR; Willems, HP, 2007) |
| "Hyperhomocysteinemia refers to an elevated circulating level of the sulfur-containing amino acid homocysteine and has been shown to be a risk factor for vascular disease in the general population." | 4.80 | Homocysteine and renal disease. ( Robinson, K; van Guldener, C, 2000) |
| "Homocystinuria (HCU) due to cystathionine beta-synthase (CBS) deficiency leads to severe hyperhomocysteinemia (HHcy)." | 4.80 | Vascular complications of severe hyperhomocysteinemia in patients with homocystinuria due to cystathionine beta-synthase deficiency: effects of homocysteine-lowering therapy. ( Boers, GH; Naughten, ER; Wilcken, B; Wilcken, DE; Yap, S, 2000) |
| " Additionally, those with thrombophilia or hyperhomocysteinemia were treated with low molecular weight heparin and with pyridoxine and folic acid supplementation, respectively." | 3.73 | Pre-pregnant prediction of recurrent preeclampsia in normotensive thrombophilic formerly preeclamptic women receiving prophylactic antithrombotic medication. ( Aardenburg, R; de Leeuw, PW; Ekhart, TH; Peeters, LL; Spaanderman, ME; van Eyndhoven, HW, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 6 (66.67) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| New, D | 1 |
| Eaton, P | 1 |
| Knable, A | 1 |
| Callen, JP | 1 |
| O'Donnell, J | 1 |
| Perry, DJ | 1 |
| Spaanderman, ME | 1 |
| Aardenburg, R | 1 |
| Ekhart, TH | 1 |
| van Eyndhoven, HW | 1 |
| de Leeuw, PW | 1 |
| Peeters, LL | 1 |
| den Heijer, M | 2 |
| Willems, HP | 2 |
| Blom, HJ | 1 |
| Gerrits, WB | 1 |
| Cattaneo, M | 2 |
| Eichinger, S | 1 |
| Rosendaal, FR | 1 |
| Bos, GM | 2 |
| Tamura, T | 1 |
| Bergman, SM | 1 |
| Morgan, SL | 1 |
| van Guldener, C | 1 |
| Robinson, K | 1 |
| Yap, S | 1 |
| Naughten, ER | 1 |
| Wilcken, B | 1 |
| Wilcken, DE | 1 |
| Boers, GH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Homocysteine Lowering by B Vitamins and the Secondary Prevention of Deep-Vein Thrombosis and Pulmonary Embolism. A Randomized, Placebo-Controlled, Double Blind Trial.[NCT00314990] | 620 participants | Interventional | 1996-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for pyridoxine and Thrombophilia
| Article | Year |
|---|---|
Pharmacotherapy of hyperhomocysteinaemia in patients with thrombophilia.
Topics: Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Methionine; Pyridoxine; Renal Insufficiency; | 2002 |
Hyperhomocysteinemia, atherosclerosis and thrombosis.
Topics: Adult; Aged; Animals; Arteriosclerosis; Avitaminosis; Case-Control Studies; Clinical Trials as Topic | 1999 |
Homocysteine and renal disease.
Topics: Adult; Arteriosclerosis; Cardiovascular Diseases; Case-Control Studies; Child; Endothelium, Vascular | 2000 |
Vascular complications of severe hyperhomocysteinemia in patients with homocystinuria due to cystathionine beta-synthase deficiency: effects of homocysteine-lowering therapy.
Topics: Adolescent; Adult; Aged; Australia; Child; Child, Preschool; Cohort Studies; Cystine; Drug Resistanc | 2000 |
2 trials available for pyridoxine and Thrombophilia
| Article | Year |
|---|---|
Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: A randomized, placebo-controlled, double-blind trial.
Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Double-Blind Method; Female; Folic Acid; | 2007 |
Homocysteine and venous thrombosis: outline of a vitamin intervention trial.
Topics: Adult; Aged; Aged, 80 and over; Comorbidity; Double-Blind Method; Female; Folic Acid; Follow-Up Stud | 2000 |
3 other studies available for pyridoxine and Thrombophilia
| Article | Year |
|---|---|
The use of B vitamins for cutaneous ulcerations mimicking pyoderma gangrenosum in patients with MTHFR polymorphism.
Topics: Adult; Child; Folic Acid; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, | 2011 |
Pre-pregnant prediction of recurrent preeclampsia in normotensive thrombophilic formerly preeclamptic women receiving prophylactic antithrombotic medication.
Topics: Adult; Birth Weight; Blood Pressure; Cardiac Output; Female; Fibrinolytic Agents; Folic Acid; Heart | 2005 |
Homocysteine, B vitamins, and vascular-access thrombosis in patients treated with hemodialysis.
Topics: Adult; Aged; Aged, 80 and over; Arteriovenous Shunt, Surgical; Blood Vessel Prosthesis; Erythrocytes | 1998 |