pyridoxine has been researched along with Syndrome in 35 studies
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
Syndrome: A characteristic symptom complex.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether concurrent pyridoxine therapy can prevent the development of hand-foot syndrome (HFS) in patients being treated with capecitabine." | 9.14 | Pyridoxine is not effective to prevent hand-foot syndrome associated with capecitabine therapy: results of a randomized, double-blind, placebo-controlled study. ( Chang, HM; Chun, YJ; Kang, YK; Kim, MS; Kim, TW; Lee, JL; Lee, SS; Lee, SY; Ryu, MH; Yoon, DH, 2010) |
| "We report intermittent seizures, lethargy, and Cohen's syndrome in a 4-year-old girl with hyper-beta-alaninemia and a partial deficiency of beta-alanyl-alpha-ketoglutarate transaminase (AKT)." | 7.69 | Pyridoxine-responsive hyper-beta-alaninemia associated with Cohen's syndrome. ( Barton, NW; Bernardini, I; Brady, RO; Higgins, JJ; Kaneski, CR, 1994) |
| "Three women with the galactorrhea-amenorrhea syndrome and elevated prolactin concentrations experienced a return of regular ovulatory menses within 37-94 days after starting pyridoxine treatment (200-600 mg/day)." | 7.65 | Treatment of women with the galactorrhea-amenorrhea syndrome with pyridoxine (vitamin B6). ( McIntosh, EN, 1976) |
| "To determine whether concurrent pyridoxine therapy can prevent the development of hand-foot syndrome (HFS) in patients being treated with capecitabine." | 5.14 | Pyridoxine is not effective to prevent hand-foot syndrome associated with capecitabine therapy: results of a randomized, double-blind, placebo-controlled study. ( Chang, HM; Chun, YJ; Kang, YK; Kim, MS; Kim, TW; Lee, JL; Lee, SS; Lee, SY; Ryu, MH; Yoon, DH, 2010) |
| "We report intermittent seizures, lethargy, and Cohen's syndrome in a 4-year-old girl with hyper-beta-alaninemia and a partial deficiency of beta-alanyl-alpha-ketoglutarate transaminase (AKT)." | 3.69 | Pyridoxine-responsive hyper-beta-alaninemia associated with Cohen's syndrome. ( Barton, NW; Bernardini, I; Brady, RO; Higgins, JJ; Kaneski, CR, 1994) |
| "The purpose of this study was to characterize the mutant enzyme in nine patients with gyrate atrophy of the choroid and retina associated with ornithine aminotransferase (OAT) deficiency, to elucidate the mechanism of response to pyridoxine in four pyridoxine-responsive patients, and to determine the extent of genetic heterogeneity in both groups of patients." | 3.67 | Gyrate atrophy of the choroid and retina: characterization of mutant ornithine aminotransferase and mechanism of response to vitamin B6. ( Kennaway, NG; Stankova, L; Weleber, RG; Wirtz, MK, 1989) |
| "Three women with the galactorrhea-amenorrhea syndrome and elevated prolactin concentrations experienced a return of regular ovulatory menses within 37-94 days after starting pyridoxine treatment (200-600 mg/day)." | 3.65 | Treatment of women with the galactorrhea-amenorrhea syndrome with pyridoxine (vitamin B6). ( McIntosh, EN, 1976) |
| "The premenstrual syndrome is diagnosed historically, with symptoms recorded meticulously on a menstrual calendar." | 2.36 | Drug therapy for the premenstrual syndrome. ( Shangold, MM, 1983) |
| "We report a case of autoimmune haemolytic anaemia complicated by ineffective erythropoiesis associated with florid sideroblastic change in the bone marrow." | 1.27 | Marrow failure with sideroblasts in an autoimmune haemolytic crisis. ( Allison, MC; Jeha, MT, 1984) |
| "An attempt to treat humans with Sjogren's syndrome by raising endogenous PGE1 production by administration of essential fatty acid PGE1 precursors, of pyridoxine and of vitamin C was successful in raising the rates of tear and saliva production." | 1.26 | Sjogren's syndrome and the sicca syndrome: the role of prostaglandin E1 deficiency. Treatment with essential fatty acids and vitamin C. ( Campbell, A; Horrobin, DF, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (74.29) | 18.7374 |
| 1990's | 3 (8.57) | 18.2507 |
| 2000's | 3 (8.57) | 29.6817 |
| 2010's | 3 (8.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kang, YK | 1 |
| Lee, SS | 1 |
| Yoon, DH | 1 |
| Lee, SY | 1 |
| Chun, YJ | 1 |
| Kim, MS | 1 |
| Ryu, MH | 1 |
| Chang, HM | 1 |
| Lee, JL | 1 |
| Kim, TW | 1 |
| Jeung, HC | 1 |
| Chung, HC | 1 |
| Wadman, M | 1 |
| ALLEVA, PM | 1 |
| ARCANGELI, A | 1 |
| ABRAMOVA, EI | 1 |
| Pearl, PL | 1 |
| Capp, PK | 1 |
| Novotny, EJ | 1 |
| Gibson, KM | 1 |
| von Moos, R | 1 |
| Thuerlimann, BJ | 1 |
| Aapro, M | 1 |
| Rayson, D | 1 |
| Harrold, K | 1 |
| Sehouli, J | 1 |
| Scotte, F | 1 |
| Lorusso, D | 1 |
| Dummer, R | 1 |
| Lacouture, ME | 1 |
| Lademann, J | 1 |
| Hauschild, A | 1 |
| Schaumburg, H | 1 |
| Kaplan, J | 1 |
| Windebank, A | 1 |
| Vick, N | 1 |
| Rasmus, S | 1 |
| Pleasure, D | 1 |
| Brown, MJ | 1 |
| Rudman, D | 1 |
| Williams, PJ | 1 |
| Shangold, MM | 1 |
| Allison, MC | 1 |
| Jeha, MT | 1 |
| London, RS | 1 |
| Sundaram, GS | 1 |
| Murphy, L | 1 |
| Goldstein, PJ | 1 |
| Folkers, K | 2 |
| Shizukuishi, S | 2 |
| Willis, R | 2 |
| Scudder, SL | 2 |
| Takemura, K | 2 |
| Longenecker, JB | 2 |
| Bottomley, SS | 1 |
| Horrobin, DF | 2 |
| Campbell, A | 2 |
| McEwen, CG | 1 |
| Higgins, JJ | 1 |
| Kaneski, CR | 1 |
| Bernardini, I | 1 |
| Brady, RO | 1 |
| Barton, NW | 1 |
| Tanase, S | 1 |
| Kuroda, Y | 1 |
| Naito, E | 1 |
| Ito, M | 1 |
| Presl, J | 1 |
| Linman, JW | 1 |
| Bagby, GC | 1 |
| Moran, JR | 1 |
| Greene, HL | 1 |
| Brush, MG | 1 |
| Taylor, RW | 1 |
| McIntosh, EN | 1 |
| Dubowitz, LM | 1 |
| Bouza, H | 1 |
| Hird, MF | 1 |
| Jaeken, J | 1 |
| Vukelja, SJ | 1 |
| Lombardo, FA | 1 |
| James, WD | 1 |
| Weiss, RB | 1 |
| Kennaway, NG | 1 |
| Stankova, L | 1 |
| Wirtz, MK | 1 |
| Weleber, RG | 1 |
| Destito, D | 1 |
| Canonico, N | 1 |
| Tentori-Montalto, T | 1 |
| Gamstorp, I | 1 |
| Wells, RS | 1 |
| Higgs, JM | 1 |
| Macdonald, A | 1 |
| Valdimarsson, H | 1 |
| Holt, PJ | 1 |
| Yaryura-Tobias, JA | 1 |
| Nair, KR | 1 |
| Virmani, V | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Double-Blind Phase III Study of Pyridoxine vs Placebo for the Prevention of Capecitabine-induced Hand-Foot Syndrome[NCT00446147] | Phase 3 | 389 participants (Actual) | Interventional | 2004-06-30 | Completed | ||
| Phase III Study of Adjuvant Capecitabine vs Observation Alone in Curatively Resected Stage IB (by AJCC 6th Edition) Gastric Cancer(KCSG ST14-05)[NCT01917552] | Phase 3 | 870 participants (Anticipated) | Interventional | 2013-08-19 | Recruiting | ||
| The Effects of Glycine Transport Inhibition on Brain Glycine Concentration[NCT00538070] | 68 participants (Actual) | Interventional | 2007-08-31 | Completed | |||
| Multicentre Randomized Phase II Study of Neoadjuvant Trastuzumab Plus Docetaxel With and Without Bevacizumab and Trastuzumab Plus Docetaxel Plus Non-pegylated Liposome-encapsulated Doxorubicin (NPLD) With and Without Bevacizumab in HER2-positive Early Bre[NCT01367028] | Phase 2 | 100 participants (Actual) | Interventional | 2011-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
A total administered dose of capecitabine until the development of grade 2 or higher hand-foot syndrome during the chemotherapy. (NCT00446147)
Timeframe: Up to 2 years
| Intervention | miligram per square meter (Median) |
|---|---|
| Placebo | 70000 |
| Pyridoxine | 70000 |
Number of patients with any grade of hand-foot syndrome (NCT00446147)
Timeframe: Up to 2 years
| Intervention | participants (Number) |
|---|---|
| Placebo | 55 |
| Pyridoxine | 57 |
6 reviews available for pyridoxine and Syndrome
| Article | Year |
|---|---|
Inherited disorders of neurotransmitters in children and adults.
Topics: Adult; Biopterins; Brain Diseases, Metabolic, Inborn; Child; Folic Acid Deficiency; Humans; Infant, | 2005 |
Drug therapy for the premenstrual syndrome.
Topics: Bromocriptine; Female; Humans; Premenstrual Syndrome; Progesterone; Pyridoxine; Spironolactone; Synd | 1983 |
Sideroblastic anaemia.
Topics: 5-Aminolevulinate Synthetase; Adult; Anemia, Sideroblastic; Blood Transfusion; Bone Marrow; Chloramp | 1982 |
[Vitamin B6 dependency syndrome (vitamin B6 dependent seizures, convulsions)].
Topics: Biomarkers; Electroencephalography; gamma-Aminobutyric Acid; Humans; Infant, Newborn; Prognosis; Pyr | 1998 |
[Vitamin dependency syndrome].
Topics: Biotin; Diagnosis, Differential; Folic Acid; Humans; Metabolism, Inborn Errors; Nervous System Disea | 2000 |
The preleukemic syndrome (hemopoietic dysplasia).
Topics: Adrenal Cortex Hormones; Aged; Antineoplastic Agents; Blood Transfusion; Bone Marrow; Child; Chromos | 1978 |
3 trials available for pyridoxine and Syndrome
| Article | Year |
|---|---|
Pyridoxine is not effective to prevent hand-foot syndrome associated with capecitabine therapy: results of a randomized, double-blind, placebo-controlled study.
Topics: Adult; Aged; Analysis of Variance; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Dou | 2010 |
Pyridoxine is not effective to prevent hand-foot syndrome associated with capecitabine therapy: results of a randomized, double-blind, placebo-controlled study.
Topics: Adult; Aged; Analysis of Variance; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Dou | 2010 |
Pyridoxine is not effective to prevent hand-foot syndrome associated with capecitabine therapy: results of a randomized, double-blind, placebo-controlled study.
Topics: Adult; Aged; Analysis of Variance; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Dou | 2010 |
Pyridoxine is not effective to prevent hand-foot syndrome associated with capecitabine therapy: results of a randomized, double-blind, placebo-controlled study.
Topics: Adult; Aged; Analysis of Variance; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Dou | 2010 |
The biochemistry of vitamin B6 is basic to the cause of the Chinese restaurant syndrome.
Topics: Aspartate Aminotransferases; Erythrocytes; Foodborne Diseases; Glutamates; Humans; Kinetics; Pyridox | 1984 |
[Analgesic activity of Benexol-B12 in the painful vertebral syndrome].
Topics: Adult; Aged; Analgesics; Clinical Trials as Topic; Drug Combinations; Humans; Middle Aged; Pain, Int | 1985 |
26 other studies available for pyridoxine and Syndrome
| Article | Year |
|---|---|
Is pyridoxine helpful in preventing palmar-plantar erythrodysesthesia associated with capecitabine?
Topics: Antimetabolites, Antineoplastic; Capecitabine; Clinical Trials as Topic; Deoxycytidine; Erythema; Fl | 2010 |
African outbreak stumps experts.
Topics: Adolescent; Animals; Centers for Disease Control and Prevention, U.S.; Child; Disease Outbreaks; Hum | 2011 |
[On the therapeutic effects of high doses of pyridoxine in extrapyramidal syndromes].
Topics: Basal Ganglia Diseases; Parkinson Disease; Pyridoxine; Spasm; Syndrome; Vitamin B 6 | 1960 |
[EPILEPTIC SYNDROMES WITHIN THE FRAMEWORK OF CHRONIC HEADACHE].
Topics: Anticonvulsants; Diencephalon; Endocrinology; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; | 1964 |
[LICHEN RUBER PLANUS AS A PECULIAR ACUTE SYNDROME].
Topics: Adolescent; Aminosalicylic Acid; Aminosalicylic Acids; Drug Therapy; Humans; Isoniazid; Lichen Planu | 1964 |
Pegylated liposomal doxorubicin-associated hand-foot syndrome: recommendations of an international panel of experts.
Topics: Adrenal Cortex Hormones; Dermatologic Agents; Doxorubicin; Drug Eruptions; Erythema; Foot Dermatoses | 2008 |
Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome.
Topics: Adult; Edema; Gait; Humans; Male; Orthomolecular Therapy; Peripheral Nervous System Diseases; Pyrido | 1983 |
Megadose vitamins. Use and misuse.
Topics: Humans; Metabolism, Inborn Errors; Nutritional Requirements; Orthomolecular Therapy; Peripheral Nerv | 1983 |
Vitamin B6 toxicity: a new megavitamin syndrome.
Topics: Adult; Ataxia; Female; Humans; Male; Orthomolecular Therapy; Peripheral Nervous System Diseases; Pyr | 1984 |
Marrow failure with sideroblasts in an autoimmune haemolytic crisis.
Topics: Adult; Anemia, Hemolytic, Autoimmune; Anemia, Sideroblastic; Bone Marrow; Erythropoiesis; Humans; Ma | 1984 |
Evaluation and treatment of breast symptoms in patients with the premenstrual syndrome.
Topics: Breast Diseases; Double-Blind Method; Female; Fibrocystic Breast Disease; Humans; Premenstrual Syndr | 1983 |
Biochemical evidence for a deficiency of vitamin B6 in subjects reacting to monosodium L-glutamate by the Chinese restaurant syndrome.
Topics: Aspartate Aminotransferases; Double-Blind Method; Erythrocytes; Food Additives; Foodborne Diseases; | 1981 |
Treatment of the Sicca syndrome and Sjogren's syndrome with E.F.A., pyridoxine and vitamin C.
Topics: Ascorbic Acid; Fatty Acids, Essential; Humans; Lacrimal Apparatus Diseases; Pyridoxine; Salivary Gla | 1981 |
Sjogren's syndrome and the sicca syndrome: the role of prostaglandin E1 deficiency. Treatment with essential fatty acids and vitamin C.
Topics: Arthritis, Rheumatoid; Ascorbic Acid; Fatty Acids, Essential; Female; Humans; Lacrimal Apparatus Dis | 1980 |
Pyridoxine-responsive hyper-beta-alaninemia associated with Cohen's syndrome.
Topics: 4-Aminobutyrate Transaminase; Abnormalities, Multiple; beta-Alanine; Child; Female; Humans; Intellec | 1994 |
[Pyridoxine and hyperprolactinemia].
Topics: Amenorrhea; Animals; Female; Galactorrhea; Haplorhini; Humans; Pregnancy; Prolactin; Pyridoxine; Syn | 1979 |
The B vitamins and vitamin C in human nutrition. I. General considerations and 'obligatory' B vitamins.
Topics: Amino Acids; Anemia, Hypochromic; Ascorbic Acid; Diet; Humans; Nutritional Physiological Phenomena; | 1979 |
Depression in men and women.
Topics: Depression; Dydrogesterone; Estradiol; Female; Humans; Male; Premenstrual Syndrome; Progesterone; Pr | 1977 |
Treatment of women with the galactorrhea-amenorrhea syndrome with pyridoxine (vitamin B6).
Topics: Adult; Amenorrhea; Female; Galactorrhea; Humans; Lactation Disorders; Menstruation; Pregnancy; Prola | 1976 |
Low cerebrospinal fluid concentration of free gamma-aminobutyric acid in startle disease.
Topics: Clonazepam; Electroencephalography; Female; gamma-Aminobutyric Acid; Humans; Infant, Newborn; Phenob | 1992 |
Pyridoxine for the palmar-plantar erythrodysesthesia syndrome.
Topics: Dermatitis, Exfoliative; Fluorouracil; Hand Dermatoses; Humans; Male; Middle Aged; Nervous System Di | 1989 |
Gyrate atrophy of the choroid and retina: characterization of mutant ornithine aminotransferase and mechanism of response to vitamin B6.
Topics: Atrophy; Cells, Cultured; Choroid; Enzyme Stability; Humans; Kinetics; Mutation; Ornithine-Oxo-Acid | 1989 |
[Vitamin B6-dependency syndrome].
Topics: Asphyxia Neonatorum; Chromosome Aberrations; Chromosome Disorders; Female; Humans; Infant, Newborn; | 1974 |
Familial chronic muco-cutaneous candidiasis.
Topics: Candida; Candida albicans; Candidiasis, Cutaneous; Candidiasis, Oral; Chronic Disease; Endocrine Sys | 1972 |
Behavioral-gluco-dysrhythmic triad.
Topics: Brain; Diet Therapy; Electroencephalography; Glucose Tolerance Test; Humans; Hypoglycemia; Phenytoin | 1973 |
Newer trends in the genetic and biochemical studies in the etiopathogenesis of aminoacidopathies.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids, Sulfur; Base Sequence; Coenzymes; DNA; Enzymes; G | 1973 |