pyridoxine has been researched along with Spasms, Infantile in 54 studies
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
Spasms, Infantile: An epileptic syndrome characterized by the triad of infantile spasms, hypsarrhythmia, and arrest of psychomotor development at seizure onset. The majority present between 3-12 months of age, with spasms consisting of combinations of brief flexor or extensor movements of the head, trunk, and limbs. The condition is divided into two forms: cryptogenic (idiopathic) and symptomatic (secondary to a known disease process such as intrauterine infections; nervous system abnormalities; BRAIN DISEASES, METABOLIC, INBORN; prematurity; perinatal asphyxia; TUBEROUS SCLEROSIS; etc.). (From Menkes, Textbook of Child Neurology, 5th ed, pp744-8)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Randomised controlled add-on trials of sulthiame in people of any age with epilepsy of any aetiology." | 8.91 | Sulthiame add-on therapy for epilepsy. ( Marson, AG; Milburn-McNulty, P; Powell, G; Sills, GJ, 2015) |
| "Pyridoxine-dependent epilepsy (PDE) is characterized by therapy-resistant seizures (TRS) responding to intravenous (IV) pyridoxine." | 7.76 | The EEG response to pyridoxine-IV neither identifies nor excludes pyridoxine-dependent epilepsy. ( Bok, LA; Brouwer, OF; de Coo, IF; Hagebeuk, EE; Jakobs, C; Maurits, NM; Poll-The, BT; Sival, DA; Teune, LK; Toet, MC; van der Hoeven, JH; Willemsen, MA, 2010) |
| "To study the difference between pyridoxine (PN) and its active form, pyridoxal phosphate, (PLP) in control of idiopathic intractable epilepsy in children." | 7.73 | Pyridoxal phosphate is better than pyridoxine for controlling idiopathic intractable epilepsy. ( Chang, MY; Chou, ML; Hsieh, MY; Hung, PC; Kuo, MF; Lin, KL; Wang, HS, 2005) |
| "Randomised controlled add-on trials of sulthiame in people of any age with epilepsy of any aetiology." | 4.91 | Sulthiame add-on therapy for epilepsy. ( Marson, AG; Milburn-McNulty, P; Powell, G; Sills, GJ, 2015) |
| "To determine whether patients with pyridoxine-responsive seizures but normal biomarkers for antiquitin deficiency and normal sequencing of the ALDH7A1 gene may have PNPO mutations." | 3.80 | Pyridoxine responsiveness in novel mutations of the PNPO gene. ( Abela, L; Clayton, P; Connolly, M; Hasselmann, O; Hofer, D; Kanz, S; Maier, O; Mills, P; Paschke, E; Paul, K; Plecko, B; Schmiedel, G; Stockler, S; Struys, E; Wolf, N, 2014) |
| "Pyridoxine-dependent epilepsy (PDE) is characterized by therapy-resistant seizures (TRS) responding to intravenous (IV) pyridoxine." | 3.76 | The EEG response to pyridoxine-IV neither identifies nor excludes pyridoxine-dependent epilepsy. ( Bok, LA; Brouwer, OF; de Coo, IF; Hagebeuk, EE; Jakobs, C; Maurits, NM; Poll-The, BT; Sival, DA; Teune, LK; Toet, MC; van der Hoeven, JH; Willemsen, MA, 2010) |
| "To study the difference between pyridoxine (PN) and its active form, pyridoxal phosphate, (PLP) in control of idiopathic intractable epilepsy in children." | 3.73 | Pyridoxal phosphate is better than pyridoxine for controlling idiopathic intractable epilepsy. ( Chang, MY; Chou, ML; Hsieh, MY; Hung, PC; Kuo, MF; Lin, KL; Wang, HS, 2005) |
| " The effects of systemic pretreatment with hydrocortisone (5-25 mg/kg), pyridoxine (20-250 mg/kg), and sodium valproate (VPA; 200 and 400 mg/kg) against the NMDA-induced automatisms, emprosthotonic (hyperflexion), and clonic-tonic seizures were determined." | 3.70 | Age-specific N-methyl-D-aspartate-induced seizures: perspectives for the West syndrome model. ( Kábová, R; Liptáková, S; Pometlová, M; Slamberová, R; Velísek, L, 1999) |
| "To determine whether high-dose, oral pyridoxine in combination with standard adrenocorticotropic hormone (ACTH) therapy has superior effectiveness than ACTH therapy alone in increasing cessation of epileptic spasms for children with West syndrome." | 3.01 | Randomized trial of high-dose pyridoxine in combination with standard hormonal therapy in West syndrome. ( Banerjee, A; Malhi, P; Negi, S; Pattanaik, S; Sahu, JK; Saini, AG; Saini, L; Sankhyan, N; Singhi, P; Suthar, R, 2021) |
| "In seven patients (58%) seizures and hypsarrhythmia stopped during the week after introduction of STM (10 mg x kg (-1)body weight day (-1))." | 2.70 | Add-on treatment with pyridoxine and sulthiame in 12 infants with West syndrome: an open clinical study. ( Debus, OM; Fiedler, B; Franssen, M; Köhring, J; Kurlemann, G, 2002) |
| "Interictal EEG showed hypsarrhythmia in 27 infants and multifocal spikes with normal or nearly normal background in 17 infants." | 2.70 | Infantile spasms: diagnosis and assessment of treatment response by video-EEG. ( Gaily, E; Granström, ML; Liukkonen, E; Paetau, R; Rekola, R, 2001) |
| "Vigabatrin is the treatment of choice when the underlying cause is tuberous sclerosis complex (TSC)." | 2.53 | Improving Outcomes in Infantile Spasms: Role of Pharmacotherapy. ( Appleton, R; Iyer, A, 2016) |
| "Valproate has also been used in the treatment of infantile spasms, with an efficacy of approximately 25 - 40%." | 2.42 | Infantile spasms. ( Zupanc, ML, 2003) |
| "Adrenocorticotropic hormone (ACTH) is probably effective for the short-term treatment of infantile spasms, but there is insufficient evidence to recommend the optimum dosage and duration of treatment." | 2.42 | Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society. ( Adams-Webber, T; Ashwal, S; Ballaban-Gill, K; Baram, TZ; Duchowny, M; Hirtz, D; Mackay, MT; Pellock, JM; Shields, WD; Shinnar, S; Snead, OC; Stephens, D; Weiss, SK; Wyllie, E, 2004) |
| " Corticotropin (adrenocorticotropic hormone) or corticosteroids have been the gold standard treatment for the last 40 years, but there is little agreement on the best agent to use, or the dosage and duration of the treatment." | 2.41 | A risk-benefit assessment of treatments for infantile spasms. ( Nabbout, R, 2001) |
| " Moreover, the dosage of corticotropin used by them is considerably smaller." | 2.39 | Medical treatment of West syndrome in Japan. ( Watanabe, K, 1995) |
| " The dosage of corticotropin was lower than previously reported." | 1.31 | Current therapy for West syndrome in Japan. ( Ito, M; Seki, T; Takuma, Y, 2000) |
| "A 7-month-old girl had congenital hydrocephaly." | 1.31 | [A case with congenital hydrocephaly and west syndrome who recovered from hypsarrhythmia after the resolution of shunt trouble]. ( Hattori, J; Kawauchi, M; Murakami, N; Ohmoto, T; Oka, E; Yoshinaga, H, 2000) |
| "Treatment with pyridoxine prevents the seizures and normalizes the EEG." | 1.29 | [Pyridoxine dependent seizures]. ( Hansen, KN; Møller, SM; Ostergaard, JR, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (25.93) | 18.7374 |
| 1990's | 18 (33.33) | 18.2507 |
| 2000's | 13 (24.07) | 29.6817 |
| 2010's | 7 (12.96) | 24.3611 |
| 2020's | 2 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Kalser, J | 1 |
| Giuliano, F | 1 |
| Peralta, M | 1 |
| Plecko, B | 4 |
| Bölsterli, BK | 1 |
| Banerjee, A | 1 |
| Sahu, JK | 2 |
| Sankhyan, N | 2 |
| Pattanaik, S | 1 |
| Suthar, R | 1 |
| Saini, AG | 1 |
| Saini, L | 1 |
| Negi, S | 1 |
| Malhi, P | 1 |
| Singhi, P | 1 |
| Xue, J | 1 |
| Qian, P | 1 |
| Li, H | 1 |
| Wu, Y | 1 |
| Xiong, H | 1 |
| Zhang, YH | 1 |
| Yang, ZX | 1 |
| Sharawat, IK | 1 |
| Kasinathan, A | 1 |
| Paul, K | 2 |
| Mills, P | 1 |
| Clayton, P | 1 |
| Paschke, E | 2 |
| Maier, O | 1 |
| Hasselmann, O | 1 |
| Schmiedel, G | 1 |
| Kanz, S | 1 |
| Connolly, M | 1 |
| Wolf, N | 1 |
| Struys, E | 2 |
| Stockler, S | 1 |
| Abela, L | 2 |
| Hofer, D | 1 |
| Milburn-McNulty, P | 1 |
| Powell, G | 1 |
| Sills, GJ | 1 |
| Marson, AG | 1 |
| Mathis, D | 1 |
| Albersen, M | 1 |
| Bürer, C | 1 |
| Crowther, L | 1 |
| Beese, K | 1 |
| Hartmann, H | 1 |
| Bok, LA | 2 |
| Papuc, SM | 1 |
| Rauch, A | 1 |
| Hersberger, M | 1 |
| Verhoeven-Duif, NM | 1 |
| Iyer, A | 1 |
| Appleton, R | 1 |
| Kluger, G | 1 |
| Blank, R | 1 |
| Jansen, E | 1 |
| Jakobs, C | 2 |
| Wörle, H | 1 |
| Maurits, NM | 1 |
| Willemsen, MA | 1 |
| Teune, LK | 1 |
| Poll-The, BT | 1 |
| de Coo, IF | 1 |
| Toet, MC | 1 |
| Hagebeuk, EE | 1 |
| Brouwer, OF | 1 |
| van der Hoeven, JH | 1 |
| Sival, DA | 1 |
| Debus, OM | 2 |
| Köhring, J | 1 |
| Fiedler, B | 1 |
| Franssen, M | 1 |
| Kurlemann, G | 4 |
| CAREDDU, P | 1 |
| FRENCH, JH | 1 |
| GRUETER, BB | 1 |
| DRUCKMAN, R | 1 |
| O'BRIEN, D | 1 |
| Zupanc, ML | 1 |
| Mackay, MT | 1 |
| Weiss, SK | 1 |
| Adams-Webber, T | 1 |
| Ashwal, S | 1 |
| Stephens, D | 1 |
| Ballaban-Gill, K | 1 |
| Baram, TZ | 1 |
| Duchowny, M | 1 |
| Hirtz, D | 1 |
| Pellock, JM | 1 |
| Shields, WD | 1 |
| Shinnar, S | 1 |
| Wyllie, E | 1 |
| Snead, OC | 1 |
| Wang, HS | 2 |
| Kuo, MF | 2 |
| Chou, ML | 1 |
| Hung, PC | 1 |
| Lin, KL | 1 |
| Hsieh, MY | 1 |
| Chang, MY | 1 |
| Miyazaki, M | 1 |
| Hashimoto, T | 1 |
| Omura, H | 1 |
| Satomura, S | 1 |
| Bando, N | 1 |
| Yoshimoto, T | 1 |
| Tayama, M | 1 |
| Kuroda, Y | 1 |
| Watanabe, K | 2 |
| Hansen, KN | 1 |
| Ostergaard, JR | 1 |
| Møller, SM | 1 |
| Vidal, R | 1 |
| Uriz, S | 1 |
| Asensio, JM | 1 |
| Fernandez Alvarez, E | 1 |
| Ohashi, N | 1 |
| Aso, K | 1 |
| Appleton, RE | 1 |
| Suzuki, Y | 1 |
| Kita, T | 1 |
| Mano, T | 1 |
| Arai, H | 1 |
| Matsuoka, T | 1 |
| Kodaka, R | 1 |
| Imai, K | 1 |
| Nagai, T | 1 |
| Okada, S | 1 |
| Deufel, T | 1 |
| Schuierer, G | 1 |
| Gerster, H | 1 |
| Siemes, H | 1 |
| Brandl, U | 1 |
| Spohr, HL | 1 |
| Völger, S | 1 |
| Weschke, B | 1 |
| Ito, M | 2 |
| Takuma, Y | 2 |
| Yoshikawa, H | 1 |
| Abe, T | 1 |
| Oda, Y | 1 |
| Kábová, R | 1 |
| Liptáková, S | 1 |
| Slamberová, R | 1 |
| Pometlová, M | 1 |
| Velísek, L | 1 |
| Baxter, P | 1 |
| Aicardi, J | 1 |
| Seki, T | 1 |
| Battaglioli, G | 1 |
| Rosen, DR | 1 |
| Gospe, SM | 1 |
| Martin, DL | 1 |
| Hattori, J | 2 |
| Yoshinaga, H | 1 |
| Murakami, N | 1 |
| Oka, E | 2 |
| Kawauchi, M | 1 |
| Ohmoto, T | 1 |
| Ohtsuka, Y | 1 |
| Ogino, T | 1 |
| Asano, T | 1 |
| Ohta, H | 1 |
| Gaily, E | 1 |
| Liukkonen, E | 1 |
| Paetau, R | 1 |
| Rekola, R | 1 |
| Granström, ML | 1 |
| Nabbout, R | 1 |
| Dubowitz, LM | 1 |
| Bouza, H | 1 |
| Hird, MF | 1 |
| Jaeken, J | 1 |
| Menges, EM | 1 |
| Palm, DG | 1 |
| Korinthenberg, R | 1 |
| Schultze, C | 1 |
| Hrachovy, RA | 1 |
| Frost, JD | 1 |
| Izuora, GI | 1 |
| Iloeje, SO | 1 |
| Zouhar, A | 1 |
| Slapal, R | 1 |
| Sugie, H | 1 |
| Sugie, Y | 1 |
| Kato, N | 1 |
| Fukuyama, Y | 1 |
| Blennow, G | 1 |
| Starck, L | 1 |
| Kroll, JS | 1 |
| Grossi-Bianchi, ML | 2 |
| Pistone, FM | 2 |
| Gandullia, E | 2 |
| Segni, G | 2 |
| Gröbe, H | 1 |
| Palm, D | 1 |
| Müller, KM | 1 |
| Notermans, SL | 1 |
| Blazsó, S | 1 |
| Fossati, P | 1 |
| Pruvot, P | 1 |
| Caridroit, M | 1 |
| Buvat, J | 1 |
| Montois, R | 1 |
| Linquette, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Vigabatrin With High Dose Prednisolone Combination Therapy Versus Vigabatrin Alone for Infantile Spasm: a Randomized Trial[NCT04302116] | 250 participants (Anticipated) | Interventional | 2020-05-18 | Recruiting | |||
| Prednisolone vs. Vigabatrin in the First-line Treatment of Infantile Spasms[NCT02299115] | Phase 3 | 0 participants (Actual) | Interventional | 2017-09-05 | Withdrawn (stopped due to Most centres are now using oral steroids as 1st line treatment so question of efficacy is no longer of high interest.) | ||
| ADRENL - ACTHAR Gel for Drug REsistant Nephrotic Syndrome in Children, Pilot Study[NCT03408405] | Phase 4 | 0 participants (Actual) | Interventional | 2018-06-30 | Withdrawn (stopped due to Withdrawal of funding from primary sponsor) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for pyridoxine and Spasms, Infantile
| Article | Year |
|---|---|
Sulthiame add-on therapy for epilepsy.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Infant; Male; Pyridoxine; Randomized Controlled Trials as | 2015 |
Improving Outcomes in Infantile Spasms: Role of Pharmacotherapy.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Humans; Infant; Pyridoxine; S | 2016 |
Infantile spasms.
Topics: Anti-Inflammatory Agents; Anticonvulsants; Humans; Infant; Infant, Newborn; Neurosurgical Procedures | 2003 |
Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child, | 2004 |
Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child, | 2004 |
Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child, | 2004 |
Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child, | 2004 |
Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child, | 2004 |
Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child, | 2004 |
Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child, | 2004 |
Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child, | 2004 |
Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child, | 2004 |
Medical treatment of West syndrome in Japan.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Cross-Cultural Comparison; Dose-Response Relationship, | 1995 |
[The importance of vitamin B 6 for development of the infant. Human medical and animal experiment studies].
Topics: Animals; Central Nervous System; Central Nervous System Diseases; Dopamine; Female; gamma-Aminobutyr | 1996 |
Pyridoxine-dependent seizures in an older child.
Topics: Child; Child, Preschool; Electroencephalography; Female; Follow-Up Studies; Humans; Infant; Infant, | 1999 |
A risk-benefit assessment of treatments for infantile spasms.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Epilepsy; Humans; Immunoglobulins; Infant; Pyridoxine; | 2001 |
Infantile spasms.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Humans; Infant; Pyridoxine; Spasms, Infantile | 1989 |
[Hypsarrhythmia].
Topics: Brain Diseases; Child; Child, Preschool; Cortisone; Diagnosis, Differential; Electroencephalography; | 1969 |
7 trials available for pyridoxine and Spasms, Infantile
| Article | Year |
|---|---|
Randomized trial of high-dose pyridoxine in combination with standard hormonal therapy in West syndrome.
Topics: Administration, Oral; Adrenocorticotropic Hormone; Drug Therapy, Combination; Humans; Infant; Pyrido | 2021 |
Add-on treatment with pyridoxine and sulthiame in 12 infants with West syndrome: an open clinical study.
Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Humans; Infant; Male; Pyridoxine; Spasms, | 2002 |
Sulthiame in the primary therapy of West syndrome: a randomized double-blind placebo-controlled add-on trial on baseline pyridoxine medication.
Topics: Anticonvulsants; Double-Blind Method; Drug Therapy, Combination; Follow-Up Studies; Humans; Infant; | 2004 |
[Outcome of initial treatment with high-dose vitamin B6, valproate sodium or clonazepam in West syndrome].
Topics: Anticonvulsants; Child; Child, Preschool; Clonazepam; Female; Humans; Infant; Male; Pyridoxine; Spas | 1996 |
Long-term follow-up study of vigabatrin in pretreated children with West syndrome.
Topics: Adrenocorticotropic Hormone; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Child, Preschool | 1998 |
ACTH therapy for infantile spasms: a combination therapy with high-dose pyridoxal phosphate and low-dose ACTH.
Topics: Age of Onset; Anticonvulsants; Child, Preschool; Cosyntropin; Drug Administration Schedule; Drug The | 1998 |
Infantile spasms: diagnosis and assessment of treatment response by video-EEG.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Brain; Carbamazepine; Clobazam; Electroenceph | 2001 |
37 other studies available for pyridoxine and Spasms, Infantile
| Article | Year |
|---|---|
Infantile Spasms without Hypsarrhythmia and Paroxysmal Eye-Head Movements in an Infant with a Pyridoxine-Dependent Epilepsy due to PLPBP/PLPHP Deficiency.
Topics: Child, Preschool; Epilepsy; Head Movements; Humans; Infant; Infant, Newborn; Pyridoxine; Spasm; Spas | 2023 |
Clinical characteristics of two cohorts of infantile spasms: response to pyridoxine or topiramate monotherapy.
Topics: Anticonvulsants; Chi-Square Distribution; Child, Preschool; China; Cohort Studies; Dose-Response Rel | 2018 |
Response to Carbamazepine in KCNQ2 Related Early Infantile Epileptic Encephalopathy.
Topics: Carbamazepine; Electroencephalography; Exons; Genetic Predisposition to Disease; Humans; KCNQ2 Potas | 2019 |
Pyridoxine responsiveness in novel mutations of the PNPO gene.
Topics: Aldehyde Dehydrogenase; Alleles; Animals; Brain Diseases, Metabolic; CHO Cells; Chromosome Deletion; | 2014 |
The value of plasma vitamin B6 profiles in early onset epileptic encephalopathies.
Topics: Adolescent; Adult; Biomarkers; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Mal | 2016 |
Pyridoxine-dependent epilepsy: normal outcome in a patient with late diagnosis after prolonged status epilepticus causing cortical blindness.
Topics: Adolescent; Aldehyde Dehydrogenase; Alleles; Anticonvulsants; Blindness, Cortical; Child; Child, Pre | 2008 |
The EEG response to pyridoxine-IV neither identifies nor excludes pyridoxine-dependent epilepsy.
Topics: Aldehyde Dehydrogenase; Diagnosis, Differential; Electroencephalography; Epilepsy; Female; Humans; I | 2010 |
[CHANGES IN TRYPTOPHAN METABOLISM IN THE WINKING-NODDING SPASM IN INFANTS].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Blinking; Blood Chemical Analysis; Chromatogra | 1963 |
PYRIDOXINE AND INFANTILE MYOCLONIC SEIZURES.
Topics: Amino Acids; Drug Therapy; Electroencephalography; Epilepsies, Myoclonic; Humans; Infant; Kynurenic | 1965 |
Pyridoxal phosphate is better than pyridoxine for controlling idiopathic intractable epilepsy.
Topics: Administration, Oral; Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Administration Sche | 2005 |
Infantile spasms with predominantly unilateral cerebral abnormalities.
Topics: Carbamazepine; Cerebral Cortex; Electroencephalography; Evoked Potentials, Auditory, Brain Stem; Evo | 1994 |
[Pyridoxine dependent seizures].
Topics: Consanguinity; Denmark; Epilepsy; Female; Genes, Recessive; Humans; Infant, Newborn; Pedigree; Pyrid | 1994 |
[West syndrome: pyridoxine insufficiency?].
Topics: Epilepsy; Female; Humans; Infant; Male; Pyridoxine; Spasms, Infantile; Vitamin B 6 Deficiency | 1993 |
The treatment of West syndrome by child neurologists in Japan.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Humans; Infant; Japan; Physicians; Pyridoxine; Spasms, | 1995 |
The treatment of infantile spasms by paediatric neurologists in the UK and Ireland.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Anticonvulsants; gamma-Aminobutyric Acid; Hum | 1996 |
Pyridoxine--responsive West syndrome and gamma-aminobutyric acid.
Topics: gamma-Aminobutyric Acid; Humans; Infant; Male; Pyridoxine; Spasms, Infantile | 1997 |
Antiepileptic drug treatment of West syndrome.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Child; Drug Administration Schedule; Drug Therapy, Com | 1998 |
Age-specific N-methyl-D-aspartate-induced seizures: perspectives for the West syndrome model.
Topics: Age Factors; Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Humans; Hydr | 1999 |
Neonatal seizures after pyridoxine use.
Topics: Breast Feeding; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; | 1999 |
Current therapy for West syndrome in Japan.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Child; Drug Therapy, Combination; Health Care Surveys; | 2000 |
Glutamate decarboxylase is not genetically linked to pyridoxine-dependent seizures.
Topics: Alleles; Child; Child, Preschool; DNA Mutational Analysis; Female; Genetic Linkage; Genetic Markers; | 2000 |
[A case with congenital hydrocephaly and west syndrome who recovered from hypsarrhythmia after the resolution of shunt trouble].
Topics: Electroencephalography; Female; Humans; Hydrocephalus; Infant; Meningitis, Bacterial; Pyridoxine; Re | 2000 |
Long-term follow-up of vitamin B(6)-responsive West syndrome.
Topics: Administration, Oral; Adolescent; Adult; Child; Child, Preschool; Dose-Response Relationship, Drug; | 2000 |
Pyridoxal phosphate-responsive epilepsy with resistance to pyridoxine.
Topics: Administration, Oral; Electroencephalography; Female; Humans; Infant, Newborn; Infant, Premature, Di | 2002 |
Low cerebrospinal fluid concentration of free gamma-aminobutyric acid in startle disease.
Topics: Clonazepam; Electroencephalography; Female; gamma-Aminobutyric Acid; Humans; Infant, Newborn; Phenob | 1992 |
Low level of GABA in CSF in vitamin B6-dependent seizures.
Topics: Electroencephalography; gamma-Aminobutyric Acid; Humans; Infant; Male; Pyridoxine; Spasms, Infantile | 1991 |
[Pyridoxine-dependent seizures. Remarks on clinical variability and pathogenesis].
Topics: Anticonvulsants; Electroencephalography; Follow-Up Studies; gamma-Aminobutyric Acid; Humans; Infant; | 1990 |
Pyridoxine therapy on Nigerian children with infantile spasms.
Topics: Administration, Oral; Electroencephalography; Female; Humans; Infant; Male; Nigeria; Pyridoxine; Spa | 1989 |
[Administration of high doses of B6 in age-related epileptic encephalopathies].
Topics: Child, Preschool; Electroencephalography; Epilepsy; Female; Humans; Infant; Male; Pyridoxine; Spasms | 1989 |
A patient with infantile spasms and low homovanillic acid levels in cerebrospinal fluid: L-dopa dependent seizures?
Topics: Dopamine; Female; Homovanillic Acid; Humans; Infant; Levodopa; Pyridoxine; Spasms, Infantile | 1989 |
High dose B6 treatment in infantile spasms.
Topics: Electroencephalography; Female; Follow-Up Studies; Humans; Infant; Pyridoxine; Spasms, Infantile | 1986 |
Pyridoxine for neonatal seizures: an unexpected danger.
Topics: Electroencephalography; Evoked Potentials; Humans; Infant, Newborn; Male; Muscle Hypotonia; Pyridoxi | 1985 |
[Association of pyridoxine and ACTH in the treatment of infantile myoclonic encephalopathy with hypsarrhythmia].
Topics: Adrenocorticotropic Hormone; Brain Diseases; Humans; Infant; Myoclonus; Pyridoxine; Spasms, Infantil | 1966 |
[The role of pyridoxine in the pathogenesis and therapy of the spastic-hypsarrhythmia syndrome. Studies and considerations on 56 cases].
Topics: Adrenocorticotropic Hormone; Drug Synergism; Electroencephalography; Humans; Infant; Infant, Newborn | 1967 |
[Pathogenesis of cerebral damage in homocystinuria].
Topics: Brain; Brain Diseases; Cerebrovascular Disorders; Child; Electroencephalography; Epilepsy; Female; H | 1973 |
[On the pharmacotherapeutic treatment of cerebral palsy. II. Treatment of oligophrenia and epilepsy].
Topics: Cerebral Palsy; Child; Child, Preschool; Chlorpromazine; Epilepsy; Epilepsy, Absence; Glutamates; Hu | 1965 |
[Familial pyridoxine deficiency in a diabetic patient and her children. Infantile myoclonic encephalopathy with hypsarrhythmia cured with vitamin B 6 in one of them].
Topics: Adult; Electroencephalography; Female; Humans; Infant; Infant, Newborn; Male; Pregnancy; Pregnancy i | 1972 |