pyridoxine has been researched along with Seizures in 310 studies
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We present the rare case of a 9-day-old with seizures refractory to multiple anticonvulsant medications who was diagnosed with pyridoxine-dependent epilepsy." | 9.22 | Pyridoxine-Dependent Epilepsy as a Cause of Neonatal Seizures. ( Case, SD; Tsao, HS, 2022) |
| "To identify pyridoxine responsive seizures among children with early onset intractable seizures, and to identify pyridoxine-dependency as a subset in this group." | 9.14 | Efficacy of pyridoxine in early-onset idiopathic intractable seizures in children. ( Gulati, S; Kalra, V; Mishra, D; Saha, N; Seth, R, 2010) |
| "In infants with frequent therapy resistant seizures (TRS-infants), clinical detection of pyridoxine-dependency (PD) or -responsiveness (PR) occurs by empirical intravenous (IV) pyridoxine administration during recording of the EEG." | 9.12 | Pyridoxine induces non-specific EEG alterations in infants with therapy resistant seizures. ( Alffenaar, JW; Bos, AF; Brouwer, OF; Maurits, NM; Reijngoud, DJ; Sival, DA; Teune, LK; vd Hoeven, JH, 2007) |
| "Pyridoxine hydrochloride, the antidote for isonicotinic acid hydrazide (INH)--induced seizures, is available in solution at a concentration of 100 mg/mL at a pH of less than 3." | 9.09 | Intravenous pyridoxine-induced metabolic acidosis. ( Curry, SC; Graeme, KA; Lovecchio, F; Suchard, J; Wallace, KL, 2001) |
| "To determine the efficacy of pyridoxine in treating seizures, 90 infants and children with recurrent convulsions primarily due to acute infectious diseases were enrolled in the present study." | 9.08 | Randomized, controlled trial of high-dose intravenous pyridoxine in the treatment of recurrent seizures in children. ( Bai, AN; Cao, YM; Chui, W; Gao, DY; Ge, ZL; Jiao, FY; Li, HR; Lieu, NS; Liu, SB; Liu, ZY; Takuma, Y; Wu, S; Zhang, XK, 1997) |
| "Pyridoxine dependency is an uncommon but important cause of intractable seizures presenting in infancy and early childhood." | 8.83 | Pyridoxine-dependent seizures: new genetic and biochemical clues to help with diagnosis and treatment. ( Gospe, SM, 2006) |
| "Pyridoxine-dependent seizures have been recognised for 40 years, but the clinical and biochemical features are still not understood." | 8.82 | Pyridoxine-dependent seizures: a clinical and biochemical conundrum. ( Baxter, P, 2003) |
| "Pyridoxine-dependent seizures are a recognized, although rare, cause of intractable seizures in neonates." | 8.81 | Pyridoxine-dependent seizures: a case report and a critical review of the literature. ( Gupta, VK; Mathur, I; Mishra, D; Singh, KK, 2001) |
| "Pyridoxine-dependent seizures, although a rare clinical entity, have been recognized as an etiology of intractable seizures in neonates and infants for more than 45 years." | 8.81 | Pyridoxine-dependent seizures: findings from recent studies pose new questions. ( Gospe, SM, 2002) |
| "Inborn errors of metabolism are a diverse group of genetic disorders including many that cause neonatal-onset epilepsy such as pyridoxine-dependent epilepsy (PDE)." | 8.31 | Pearls & Oy-sters: Delayed Response to Pyridoxine in Pyridoxine-Dependent Epilepsy. ( Anwar, T; Christoffel, K; Donoho, K; Fortin, O; Kousa, Y; Leon, E; Miller, I; Mulkey, SB, 2023) |
| "To investigate the short-term efficacy and safety of high-dose pyridoxine and pyridoxal 5-phosphate (P5P) in the treatment of inherited glycosylphosphatidylinositol (GPI) deficiency-associated epilepsy." | 8.12 | Pyridoxine or pyridoxal-5-phosphate treatment for seizures in glycosylphosphatidylinositol deficiency: A cohort study. ( Aledo-Serrano, A; Bayat, A; Boßelmann, C; de Sain-van der Velden, MGM; Gardella, E; Gil-Nagel, A; Korff, CM; Lund, AM; Møller, RS; Thomas, A; Weber, Y, 2022) |
| " Pyridoxine-dependent epilepsy (PDE) is a treatable disorder associated with defects in the one of ALDH7A1, PNPO, or PLPBP genes and it is uncommon but progresses with persistent seizures in the neonatal and infancy period." | 8.12 | Pyridoxine-dependent Epilepsy caused by a Novel homozygous mutation in PLPBP Gene. ( Çavdartepe, BE; İpek, R; Kor, D; Okuyaz, Ç, 2022) |
| " This simulation-based curriculum involves the identification and management of a seizure in a 4-day-old neonate with pyridoxine-dependent epilepsy." | 7.88 | High-Fidelity Simulation Scenario: Pyridoxine-Dependent Epilepsy and Treatment. ( Anderson, J; Arboleda, N; Calleo, V, 2018) |
| "We report treatment outcome of eleven patients with pyridoxine-dependent epilepsy caused by pathogenic variants in ALDH7A1 (PDE-ALDH7A1)." | 7.85 | Phenotype, biochemical features, genotype and treatment outcome of pyridoxine-dependent epilepsy. ( Al Teneiji, A; Bruun, TU; Cordeiro, D; Inbar-Feigenberg, M; Mercimek-Mahmutoglu, S; Patel, J; Struys, E; Weiss, S, 2017) |
| "To analyze the clinical and genetic characteristics of patients with pyridoxine dependent epilepsy (PDE), and build a method to detect and analyze the concentration of urinary pipecolic acid in PDE patients receiving pyridoxine treatment." | 7.83 | [Clinical and genetic characteristics and detection of urinary pipecolic acid in pyridoxine dependent epilepsy]. ( Jiang, YW; Li, H; Liu, XY; Qian, P; Wu, Y; Xue, J; Yang, ZX, 2016) |
| "Pyridoxine-dependent epilepsy (PDE) is an autosomal recessive disorder characterized by early onset and recurrent seizures that can be controlled by a high dose of pyridoxine." | 7.81 | Seizure recurrence following pyridoxine withdrawal in a patient with pyridoxine-dependent epilepsy. ( Iai, M; Osaka, H; Shimbo, H; Tamaura, M; Yamashita, S, 2015) |
| "Pyridoxine-dependent epilepsy (PDE) is a rare autosomal recessive disorder characterized by intractable seizures in neonates and infants." | 7.81 | First cases of pyridoxine-dependent epilepsy in Bulgaria: novel mutation in the ALDH7A1 gene. ( Bojidarova, M; Georgieva, B; Georgieva, R; Kadiyska, T; Litvinenko, I; Mitev, V; Stamatov, D; Tacheva, G; Tincheva, S; Todorov, T; Todorova, A; Yordanova, I, 2015) |
| "An 8-year-old girl treated at our facility for superrefractory status epilepticus was found to have a low pyridoxine level at 5 μg/L." | 7.81 | Pyridoxine deficiency in adult patients with status epilepticus. ( Dave, HN; Eugene Ramsay, R; Irland, M; Khan, F; Sabharwal, V, 2015) |
| "Pyridoxine-dependent epilepsy (PDE) is a rare autosomal recessive disorder causing intractable seizures in neonates and infants." | 7.78 | Pyridoxine-dependent epilepsy: an under-recognised cause of intractable seizures. ( Brigati, G; Capovilla, G; Falsaperla, R; Striano, P; Yeghiazaryan, NS; Zara, F, 2012) |
| " Therefore, a decarboxylase-positive modulator, namely pyridoxine, was taken for interaction studies with clobenpropit in the electroshock (ES) model of seizures in mice and subsequent changes in brain histamine levels were estimated." | 7.77 | Beneficial interaction between clobenpropit and pyridoxine in prevention of electroshock-induced seizures in mice: lack of histaminergic mechanisms. ( Khanam, R; Manocha, A; Uma Devi, P; Vohora, D, 2011) |
| "Incidental reports suggest that antenatal treatment of pyridoxine dependent seizures (PDS) may improve neurodevelopmental outcome of affected patients." | 7.76 | Antenatal treatment in two Dutch families with pyridoxine-dependent seizures. ( Been, JV; Bok, LA; Jakobs, C; Rijper, EA; Struys, EA; Willemsen, MA, 2010) |
| "We report on seizures, paroxysmal events, and electroencephalogram (EEG) findings in four female infants with pyridoxine-dependent epilepsy (PDE) and in one female with pyridoxine phosphate oxidase deficiency (PNPO)." | 7.76 | Seizures and paroxysmal events: symptoms pointing to the diagnosis of pyridoxine-dependent epilepsy and pyridoxine phosphate oxidase deficiency. ( Baumgartner, M; Clayton, PT; Jakobs, C; Keller, E; Mills, PB; Schmitt, B; Wohlrab, G, 2010) |
| "Pyridoxine-dependent seizures (PDS) is a rare autosomal recessive disorder causing intractable seizures in neonates and infants." | 7.75 | Two novel ALDH7A1 (antiquitin) splicing mutations associated with pyridoxine-dependent seizures. ( Battaglia, S; Beccaria, F; Capovilla, G; Giordano, L; Jakobs, C; Salomons, GS; Striano, P; Struys, EA, 2009) |
| "To facilitate clinical research on pyridoxine-dependent seizures (PDS), a rare disease registry was established for affected patients in the United States and Canada." | 7.75 | Clinical features and the management of pyridoxine-dependent and pyridoxine-responsive seizures: review of 63 North American cases submitted to a patient registry. ( Basura, GJ; Gospe, SM; Hagland, SP; Wiltse, AM, 2009) |
| "Folinic acid-responsive seizures and pyridoxine-dependent epilepsy are two treatable causes of neonatal epileptic encephalopathy." | 7.75 | Folinic acid-responsive seizures are identical to pyridoxine-dependent epilepsy. ( Gallagher, RC; Hyland, K; Jakobs, C; Mercimek-Mahmutoglu, S; Plecko, B; Rosenberg, EH; Salomons, GS; Scharer, G; Stockler-Ipsiroglu, S; Struys, EA; Van Hove, JL; Waters, PJ, 2009) |
| "Pyridoxine-dependent seizures are a rare condition recognized when numerous seizures respond to pyridoxine treatment and recur on pyridoxine withdrawal." | 7.74 | Pyridoxine-dependent seizures caused by alpha amino adipic semialdehyde dehydrogenase deficiency: the first polish case with confirmed biochemical and molecular pathology. ( Jakobs, C; Jozwiak, S; Kacinski, M; Kaczorowska, M; Kmiec, T; Kroczka, S; Salomons, GS; Struys, EA, 2008) |
| "Pyridoxine-dependent seizures (PDS) is a rare, autosomal recessively inherited disorder." | 7.74 | Pyridoxine-dependent seizures in Dutch patients: diagnosis by elevated urinary alpha-aminoadipic semialdehyde levels. ( Been, JV; Bok, LA; Jakobs, C; Struys, E; Willemsen, MA, 2007) |
| "Pyridoxine-responsive seizures (PRS) and the role of pyridoxine (PN, vitamin B(6)) in hypophosphatasia (HPP) are incompletely understood." | 7.74 | Pyridoxine-responsive seizures as the first symptom of infantile hypophosphatasia caused by two novel missense mutations (c.677T>C, p.M226T; c.1112C>T, p.T371I) of the tissue-nonspecific alkaline phosphatase gene. ( Baumgartner-Sigl, S; Ericson, KL; Haberlandt, E; Högler, W; Mumm, S; Ryan, L; Scholl-Bürgi, S; Sergi, C; Whyte, MP, 2007) |
| "Pyridoxine dependent seizure (PDS) is a disorder of neonates or infants with autosomal recessive inheritance characterized by seizures, which responds to pharmacological dose of pyridoxine." | 7.74 | Allelic and non-allelic heterogeneities in pyridoxine dependent seizures revealed by ALDH7A1 mutational analysis. ( Aoki, Y; Baumeister, FA; Goto, T; Haginoya, K; Hasegawa, Y; Hoshino, H; Kamada, F; Kanno, J; Kure, S; Matsubara, Y; Narisawa, A; Takahashi, T; Takayanagi, M; Tsuchiya, S; Yamaguchi, S; Yamamoto, K, 2007) |
| "To study the difference between pyridoxine (PN) and its active form, pyridoxal phosphate, (PLP) in control of idiopathic intractable epilepsy in children." | 7.73 | Pyridoxal phosphate is better than pyridoxine for controlling idiopathic intractable epilepsy. ( Chang, MY; Chou, ML; Hsieh, MY; Hung, PC; Kuo, MF; Lin, KL; Wang, HS, 2005) |
| "Both isoniazid (INH) and cefazolin (CEZ) can have serious adverse effects on the central nervous system (CNS), causing seizures." | 7.73 | Effect of isoniazid on the pharmacodynamics of cefazolin-induced seizures in rats. ( Ishiwata, Y; Nagata, M; Yasuhara, M, 2005) |
| " Acute isoniazid intoxication is characterized by a clinical triad consisting of metabolic acidosis resistant to treatment with sodium bicarbonate, seizures which may be fatal and refractory to standard anticonvulsant therapy, and coma." | 7.73 | Seizures, metabolic acidosis and coma resulting from acute isoniazid intoxication. ( Ekici, NZ; Kefi, A; Sakarya, M; Topcu, I; Yentur, EA, 2005) |
| "Determine the prevalence of pyridoxine dependent seizures in children less than 16 years of age attending a teaching hospital in south India with early onset (before 3 years) intractable epilepsy of unknown aetiology, using the criteria proposed by Baxter." | 7.73 | Prevalence of pyridoxine dependent seizures in south Indian children with early onset intractable epilepsy: A hospital based prospective study. ( Parameswaran, M; Ramachandrannair, R, 2005) |
| "We show here that children with pyridoxine-dependent seizures (PDS) have mutations in the ALDH7A1 gene, which encodes antiquitin; these mutations abolish the activity of antiquitin as a delta1-piperideine-6-carboxylate (P6C)-alpha-aminoadipic semialdehyde (alpha-AASA) dehydrogenase." | 7.73 | Mutations in antiquitin in individuals with pyridoxine-dependent seizures. ( Baumgartner, M; Baxter, P; Clayton, PT; Jakobs, C; Mills, PB; Omran, H; Plecko, B; Struys, E; Tacke, U; Uhlenberg, B; Weschke, B; Willemsen, MA, 2006) |
| "Pyridoxine-dependent seizures is an autosomal, recessively inherited inborn error of metabolism with recurrent long-lasting seizures with onset usually in infancy, but also up to three years of age." | 7.72 | [Pyridoxine-dependent seizures]. ( Akre, B; Lundby, R; Rasmussen, M, 2004) |
| "Pyridoxine dependency is a rare autosomal-recessive disorder causing intractable seizures in neonates and infants." | 7.72 | Pyridoxine-dependent seizures and microcephaly. ( Büyükavci, M; Karakelleoğlu, C; Kardaş, F; Tan, H, 2004) |
| "We previously identified vitamin B6 deficiency in a child presenting with seizures whose primary diagnosis was the inherited disorder hyperprolinemia type II." | 7.71 | Pyridoxal phosphate de-activation by pyrroline-5-carboxylic acid. Increased risk of vitamin B6 deficiency and seizures in hyperprolinemia type II. ( Farrant, RD; Langley, GJ; Mellor, JM; Mills, GA; Walker, V, 2001) |
| "Several lines of evidence suggest that the binding affinity of glutamate decarboxylase (GAD) to the active form of pyridoxine is low in cases of pyridoxine-dependent seizures (PDS) and that a quantitative imbalance between excitatory (i." | 7.71 | CSF glutamate/GABA concentrations in pyridoxine-dependent seizures: etiology of pyridoxine-dependent seizures and the mechanisms of pyridoxine action in seizure control. ( Goto, T; Matsuo, N; Takahashi, T, 2001) |
| "Pyridoxine dependency and congenital hypophosphatasia are unusual metabolic disorders." | 7.71 | Pyridoxine-dependent seizures associated with hypophosphatasia in a newborn. ( Bica, I; Fiori, RM; Mugnol, F; Nunes, ML, 2002) |
| "Isoniazid-induced seizures respond poorly to anticonvulsants but well to pyridoxine (Vitamin B6); theophylline produces difficult-to-treat seizures with substantial morbidity and mortality." | 7.70 | Seizures induced by theophylline and isoniazid in mice. ( Bonner, AB; Peterson, SL; Weir, MR, 1999) |
| "To study the epidemiology of pyridoxine dependent seizures and other forms of pyridoxine responsive seizures." | 7.70 | Epidemiology of pyridoxine dependent and pyridoxine responsive seizures in the UK. ( Baxter, P, 1999) |
| "An 18-year-old man was treated from birth with chronic high dose pyridoxine (vitamin B6) up to 2000 mg per day for pyridoxine-dependent seizures." | 7.69 | Pyridoxine dependent epilepsy with iatrogenic sensory neuronopathy. ( Brown, WF; McLachlan, RS, 1995) |
| "Pyridoxine-dependent seizures are a disorder of GABA metabolism probably due to a defective binding of pyridoxal phosphate coenzyme (PALP) with glutamate decarboxylase (GAD), the rate-limiting enzyme in GABA synthesis." | 7.69 | Pyridoxine-dependent seizures associated with white matter abnormalities. ( Giugliani, R; Jardim, LB; Kliemann, FA; Martins, CE; Pires, RF; Vargas, CR; Vizioli, J, 1994) |
| "An abnormality in the pyridoxal-5'-phosphate (PLP) dependent enzyme, glutamic acid decarboxylase (GAD), which synthesizes gamma-aminobutyric acid (GABA), may underlie the epileptic syndrome of pyridoxine-dependent seizures." | 7.69 | Reduced GABA synthesis in pyridoxine-dependent seizures. ( Gospe, SM; Keen, CL; Olin, KL, 1994) |
| "Theophylline-induced seizures have significant morbidity and mortality and are difficult to treat." | 7.69 | Pyridoxine as therapy in theophylline-induced seizures. ( Glenn, GM; Kelly, P; Krober, MS; McCarty, J; Weir, M, 1995) |
| "To report a case of reversible seizures and mental status changes in a dialysis patient given preventive isoniazid therapy." | 7.68 | Reversible seizures and mental status changes in a dialysis patient on isoniazid preventive therapy. ( Asnis, DS; Bhat, JG; Melchert, AF, 1993) |
| "In an infant with typical pyridoxine-dependent seizures, CSF GABA level, was determined before treatment with pyridoxine." | 7.68 | Disturbance of GABA metabolism in pyridoxine-dependent seizures. ( Bömelburg, T; Grüneberg, M; Kurlemann, G; Palm, DG; Ullrich, K; Ziegler, R, 1992) |
| "A Japanese girl with atypical pyridoxine-dependent seizures is reported." | 7.68 | Pyridoxine-dependent seizures: report of a case with atypical clinical features and abnormal MRI scans. ( Arima, J; Momoi, T; Okumura, M; Tanaka, R; Yamakura, S, 1992) |
| "A patient of pyridoxine dependent seizures was reported." | 7.68 | [Chronological change of EEG findings in a case of pyridoxine dependency seizures]. ( Abe, J; Futagi, Y; Koga, R; Otani, K; Takeuchi, T; Yabuuchi, H, 1990) |
| "In rabbits, generalized seizures were induced by methoxypyridoxine, and changes in amino acid concentrations of 15 brain regions were investigated before seizure onset and during the course of sustained epileptiform activity." | 7.66 | Alterations in the content of amino acid neurotransmitters before the onset and during the course of methoxypyridoxine-induced seizures in individual rabbit brain regions. ( Haug, P; Nitsch, C; Schmude, B, 1983) |
| "Pyridoxine-dependent seizures occur as a result of an increased requirement of the vitamin within the central nervous system." | 7.66 | Pyridoxine-dependent seizures. ( Crowell, GF; Roach, ES, 1983) |
| "We report 4 infants with pyridoxine dependent seizures who had clinical features that led to diagnostic uncertainty." | 7.66 | Pyridoxine dependent seizures--a wider clinical spectrum. ( Bankier, A; Hopkins, IJ; Turner, M, 1983) |
| "The effects of pyridoxine deficiency and the administration of supplemental vitamin B6 on audiogenic and electroconvulsive seizures were studied in two inbred strains of mice and their F1 hybrids." | 7.65 | Levels of pyridoxine and susceptibility to electroconvulsive and audiogenic seizures. ( Lieff, B; Schlesinger, K, 1975) |
| "Pyridoxine-dependency is a rare autosomal recessive disorder causing a severe seizure disorder of prenatal or neonatal onset, psychomotor retardation and death in untreated patients." | 6.38 | Pyridoxine-dependent seizures, clinical and therapeutic aspects. ( Girardin, E; Haenggeli, CA; Paunier, L, 1991) |
| "Hypophosphatasia is a rare inherited disorder of bone and mineral metabolism caused by a number of loss-of-function mutations in the ALPL gene." | 5.43 | Pyridoxine-Responsive Seizures in Infantile Hypophosphatasia and a Novel Homozygous Mutation in ALPL Gene. ( Bircan, İ; Çelmeli, G; Güzel Nur, B; Manguoğlu, E; Mıhçı, E; Soyucen, E, 2016) |
| "We aimed to assess the efficacy and safety of high-dose pyridoxine treatment for seizures and its effects on development in patients with inherited glycosylphosphatidylinositol deficiencies (IGDs)." | 5.41 | High-dose pyridoxine treatment for inherited glycosylphosphatidylinositol deficiency. ( Kinosita, T; Maegaki, Y; Murakami, Y; Nabatame, S; Nishimura, Y; Ozono, K; Tanigawa, J; Tominaga, K, 2021) |
| "Pyridoxal phosphate was extremely high in CSF and plasma." | 5.40 | Infantile hypophosphatasia without bone deformities presenting with severe pyridoxine-resistant seizures. ( Abeling, NGGM; Bosch, AM; Cobben, JM; de Roo, MGA; Duran, M; Koelman, JHTM; Majoie, CB; Poll-The, BT, 2014) |
| "Pyridoxine-dependent seizure (PDS) is a rare autosomal recessive intractable seizure disorder only controlled by a daily supplementation of pharmacological doses of pyridoxine (Vitamin B6)." | 5.33 | Genetic heterogeneity for autosomal recessive pyridoxine-dependent seizures. ( Bennett, CL; Chance, PF; Glass, IA; Gospe, SM; Huynh, HM, 2005) |
| "There was no difference in onset of seizure time between the pyridoxine-treated group of rats and the control rats." | 5.33 | Pyridoxine does not prevent hyperbaric oxygen-induced seizures in rats. ( Cameron, D; Chase, PB; Fernandez, MC; Roe, DJ; Walter, FG; Wolfson, M, 2006) |
| "Pyridoxine-dependency is a rare autosomal recessive disorder causing a severe seizure disorder of neonatal onset." | 5.31 | Pyridoxine-dependent seizures: long-term follow-up of two cases with clinical and MRI findings, and pyridoxine treatment. ( Müngen, B; Ulvi, H; Yakinci, C; Yoldaş, T, 2002) |
| "She was in respiratory failure, with seizures that could not be stopped with diazepam." | 5.29 | [Pyridoxine for severe metabolic acidosis and seizures due to isoniazid overdose]. ( Adler, M; Girsh-Solomonovich, Z; Raikhlin-Eisenkraft, B, 1993) |
| " The dosage of pyridoxine should be optimal for IQ as well as seizure control." | 5.29 | Pyridoxine-dependent seizures: demographic, clinical, MRI and psychometric features, and effect of dose on intelligence quotient. ( Baxter, P; Gardner-Medwin, D; Griffiths, P; Kelly, T, 1996) |
| "Seizures were induced by intravenous injection of 100 mg kg-1 methoxypyridoxine; 40 minutes later the animals were decapitated and discrete brain areas removed." | 5.26 | Selected ion monitoring determination of acetylcholine during methoxypyridoxine seizures. ( Haug, P; Nitsch, C; Schmude, B; Suzuki, M; Wunn, W, 1980) |
| "In mice, the ED(50) values for seizures following intraperitoneal injection were allylglycine 1." | 5.25 | Seizures induced by allylglycine, 3-mercaptopropionic acid and 4-deoxypyridoxine in mice and photosensitive baboons, and different modes of inhibition of cerebral glutamic acid decarboxylase. ( Horton, RW; Meldrum, BS, 1973) |
| " We present the rare case of a 9-day-old with seizures refractory to multiple anticonvulsant medications who was diagnosed with pyridoxine-dependent epilepsy." | 5.22 | Pyridoxine-Dependent Epilepsy as a Cause of Neonatal Seizures. ( Case, SD; Tsao, HS, 2022) |
| "To identify pyridoxine responsive seizures among children with early onset intractable seizures, and to identify pyridoxine-dependency as a subset in this group." | 5.14 | Efficacy of pyridoxine in early-onset idiopathic intractable seizures in children. ( Gulati, S; Kalra, V; Mishra, D; Saha, N; Seth, R, 2010) |
| "In infants with frequent therapy resistant seizures (TRS-infants), clinical detection of pyridoxine-dependency (PD) or -responsiveness (PR) occurs by empirical intravenous (IV) pyridoxine administration during recording of the EEG." | 5.12 | Pyridoxine induces non-specific EEG alterations in infants with therapy resistant seizures. ( Alffenaar, JW; Bos, AF; Brouwer, OF; Maurits, NM; Reijngoud, DJ; Sival, DA; Teune, LK; vd Hoeven, JH, 2007) |
| "Pyridoxine hydrochloride, the antidote for isonicotinic acid hydrazide (INH)--induced seizures, is available in solution at a concentration of 100 mg/mL at a pH of less than 3." | 5.09 | Intravenous pyridoxine-induced metabolic acidosis. ( Curry, SC; Graeme, KA; Lovecchio, F; Suchard, J; Wallace, KL, 2001) |
| "To determine the efficacy of pyridoxine in treating seizures, 90 infants and children with recurrent convulsions primarily due to acute infectious diseases were enrolled in the present study." | 5.08 | Randomized, controlled trial of high-dose intravenous pyridoxine in the treatment of recurrent seizures in children. ( Bai, AN; Cao, YM; Chui, W; Gao, DY; Ge, ZL; Jiao, FY; Li, HR; Lieu, NS; Liu, SB; Liu, ZY; Takuma, Y; Wu, S; Zhang, XK, 1997) |
| " The prototype is pyridoxine dependency, although pyridoxal 5'-phosphate dependency is a recently recognized but treatable neonatal epilepsy that deserves earmarked distinction." | 4.85 | New treatment paradigms in neonatal metabolic epilepsies. ( Pearl, PL, 2009) |
| "Pyridoxine dependency is an uncommon but important cause of intractable seizures presenting in infancy and early childhood." | 4.83 | Pyridoxine-dependent seizures: new genetic and biochemical clues to help with diagnosis and treatment. ( Gospe, SM, 2006) |
| "Pyridoxine-dependent seizures have been recognised for 40 years, but the clinical and biochemical features are still not understood." | 4.82 | Pyridoxine-dependent seizures: a clinical and biochemical conundrum. ( Baxter, P, 2003) |
| " Disruptions of glutamate metabolism have been implicated in other clinical disorders, such as pyridoxine-dependent seizures, confirming the importance of intact glutamate metabolism." | 4.81 | Disorders of glutamate metabolism. ( Kelly, A; Stanley, CA, 2001) |
| "Pyridoxine-dependent seizures are a recognized, although rare, cause of intractable seizures in neonates." | 4.81 | Pyridoxine-dependent seizures: a case report and a critical review of the literature. ( Gupta, VK; Mathur, I; Mishra, D; Singh, KK, 2001) |
| "Pyridoxine-dependent seizures, although a rare clinical entity, have been recognized as an etiology of intractable seizures in neonates and infants for more than 45 years." | 4.81 | Pyridoxine-dependent seizures: findings from recent studies pose new questions. ( Gospe, SM, 2002) |
| "Inborn errors of metabolism are a diverse group of genetic disorders including many that cause neonatal-onset epilepsy such as pyridoxine-dependent epilepsy (PDE)." | 4.31 | Pearls & Oy-sters: Delayed Response to Pyridoxine in Pyridoxine-Dependent Epilepsy. ( Anwar, T; Christoffel, K; Donoho, K; Fortin, O; Kousa, Y; Leon, E; Miller, I; Mulkey, SB, 2023) |
| "To investigate the short-term efficacy and safety of high-dose pyridoxine and pyridoxal 5-phosphate (P5P) in the treatment of inherited glycosylphosphatidylinositol (GPI) deficiency-associated epilepsy." | 4.12 | Pyridoxine or pyridoxal-5-phosphate treatment for seizures in glycosylphosphatidylinositol deficiency: A cohort study. ( Aledo-Serrano, A; Bayat, A; Boßelmann, C; de Sain-van der Velden, MGM; Gardella, E; Gil-Nagel, A; Korff, CM; Lund, AM; Møller, RS; Thomas, A; Weber, Y, 2022) |
| " Pyridoxine-dependent epilepsy (PDE) is a treatable disorder associated with defects in the one of ALDH7A1, PNPO, or PLPBP genes and it is uncommon but progresses with persistent seizures in the neonatal and infancy period." | 4.12 | Pyridoxine-dependent Epilepsy caused by a Novel homozygous mutation in PLPBP Gene. ( Çavdartepe, BE; İpek, R; Kor, D; Okuyaz, Ç, 2022) |
| " It frequently accompanies pyridoxine-responsive seizures." | 3.91 | Findings of amplitude-integrated electroencephalogram recordings and serum vitamin B6 metabolites in perinatal lethal hypophosphatasia during enzyme replacement therapy. ( Akiyama, T; Hayakawa, M; Ishiguro, T; Kotani, T; Michigami, T; Muramatsu, Y; Sugiyama, Y; Tachikawa, K; Tsuda, H; Ueda, K, 2019) |
| " This simulation-based curriculum involves the identification and management of a seizure in a 4-day-old neonate with pyridoxine-dependent epilepsy." | 3.88 | High-Fidelity Simulation Scenario: Pyridoxine-Dependent Epilepsy and Treatment. ( Anderson, J; Arboleda, N; Calleo, V, 2018) |
| " A dramatic therapeutic response to pyridoxine was observed in the only patient who still had active seizures when starting treatment, while in all three patients interictal EEG discharges and background activity improved after pyridoxine treatment was initiated." | 3.85 | Pyridoxine-5'-phosphate oxidase (Pnpo) deficiency: Clinical and biochemical alterations associated with the C.347g>A (P.·Arg116gln) mutation. ( Carducci, C; Contestabile, R; di Salvo, ML; Guerrini, R; Leuzzi, V; Mastrangelo, M; Mei, D; Montomoli, M; Nogués, I; Paiardini, A; Tolve, M; Tramonti, A, 2017) |
| "We report treatment outcome of eleven patients with pyridoxine-dependent epilepsy caused by pathogenic variants in ALDH7A1 (PDE-ALDH7A1)." | 3.85 | Phenotype, biochemical features, genotype and treatment outcome of pyridoxine-dependent epilepsy. ( Al Teneiji, A; Bruun, TU; Cordeiro, D; Inbar-Feigenberg, M; Mercimek-Mahmutoglu, S; Patel, J; Struys, E; Weiss, S, 2017) |
| "To analyze the clinical and genetic characteristics of patients with pyridoxine dependent epilepsy (PDE), and build a method to detect and analyze the concentration of urinary pipecolic acid in PDE patients receiving pyridoxine treatment." | 3.83 | [Clinical and genetic characteristics and detection of urinary pipecolic acid in pyridoxine dependent epilepsy]. ( Jiang, YW; Li, H; Liu, XY; Qian, P; Wu, Y; Xue, J; Yang, ZX, 2016) |
| "Pyridoxine-dependent epilepsy (PDE) is an autosomal recessive disorder characterized by early onset and recurrent seizures that can be controlled by a high dose of pyridoxine." | 3.81 | Seizure recurrence following pyridoxine withdrawal in a patient with pyridoxine-dependent epilepsy. ( Iai, M; Osaka, H; Shimbo, H; Tamaura, M; Yamashita, S, 2015) |
| "Pyridoxine-dependent epilepsy (PDE) is a rare autosomal recessive disorder characterized by intractable seizures in neonates and infants." | 3.81 | First cases of pyridoxine-dependent epilepsy in Bulgaria: novel mutation in the ALDH7A1 gene. ( Bojidarova, M; Georgieva, B; Georgieva, R; Kadiyska, T; Litvinenko, I; Mitev, V; Stamatov, D; Tacheva, G; Tincheva, S; Todorov, T; Todorova, A; Yordanova, I, 2015) |
| "An 8-year-old girl treated at our facility for superrefractory status epilepticus was found to have a low pyridoxine level at 5 μg/L." | 3.81 | Pyridoxine deficiency in adult patients with status epilepticus. ( Dave, HN; Eugene Ramsay, R; Irland, M; Khan, F; Sabharwal, V, 2015) |
| "To determine whether patients with pyridoxine-responsive seizures but normal biomarkers for antiquitin deficiency and normal sequencing of the ALDH7A1 gene may have PNPO mutations." | 3.80 | Pyridoxine responsiveness in novel mutations of the PNPO gene. ( Abela, L; Clayton, P; Connolly, M; Hasselmann, O; Hofer, D; Kanz, S; Maier, O; Mills, P; Paschke, E; Paul, K; Plecko, B; Schmiedel, G; Stockler, S; Struys, E; Wolf, N, 2014) |
| "Pyridoxine-dependent epilepsy (PDE) is a rare autosomal recessive disorder causing intractable seizures in neonates and infants." | 3.78 | Pyridoxine-dependent epilepsy: an under-recognised cause of intractable seizures. ( Brigati, G; Capovilla, G; Falsaperla, R; Striano, P; Yeghiazaryan, NS; Zara, F, 2012) |
| " Therefore, a decarboxylase-positive modulator, namely pyridoxine, was taken for interaction studies with clobenpropit in the electroshock (ES) model of seizures in mice and subsequent changes in brain histamine levels were estimated." | 3.77 | Beneficial interaction between clobenpropit and pyridoxine in prevention of electroshock-induced seizures in mice: lack of histaminergic mechanisms. ( Khanam, R; Manocha, A; Uma Devi, P; Vohora, D, 2011) |
| "In children, vitamin B(6) (pyridoxine) deficiency has been described as a cause of seizures that are refractory to conventional antiepileptic medications." | 3.77 | Vitamin B6 deficiency: a potential cause of refractory seizures in adults. ( Cook, CH; Gerlach, AT; Stawicki, SP; Steinberg, SM; Thomas, S; Whitmill, ML, 2011) |
| "Incidental reports suggest that antenatal treatment of pyridoxine dependent seizures (PDS) may improve neurodevelopmental outcome of affected patients." | 3.76 | Antenatal treatment in two Dutch families with pyridoxine-dependent seizures. ( Been, JV; Bok, LA; Jakobs, C; Rijper, EA; Struys, EA; Willemsen, MA, 2010) |
| "We report on seizures, paroxysmal events, and electroencephalogram (EEG) findings in four female infants with pyridoxine-dependent epilepsy (PDE) and in one female with pyridoxine phosphate oxidase deficiency (PNPO)." | 3.76 | Seizures and paroxysmal events: symptoms pointing to the diagnosis of pyridoxine-dependent epilepsy and pyridoxine phosphate oxidase deficiency. ( Baumgartner, M; Clayton, PT; Jakobs, C; Keller, E; Mills, PB; Schmitt, B; Wohlrab, G, 2010) |
| "Pyridoxine-dependent seizures (PDS) is a rare autosomal recessive disorder causing intractable seizures in neonates and infants." | 3.75 | Two novel ALDH7A1 (antiquitin) splicing mutations associated with pyridoxine-dependent seizures. ( Battaglia, S; Beccaria, F; Capovilla, G; Giordano, L; Jakobs, C; Salomons, GS; Striano, P; Struys, EA, 2009) |
| "To facilitate clinical research on pyridoxine-dependent seizures (PDS), a rare disease registry was established for affected patients in the United States and Canada." | 3.75 | Clinical features and the management of pyridoxine-dependent and pyridoxine-responsive seizures: review of 63 North American cases submitted to a patient registry. ( Basura, GJ; Gospe, SM; Hagland, SP; Wiltse, AM, 2009) |
| "Pyridoxine-dependent seizure (PDS) is a rare disorder characterized by seizures that are resistant to common anticonvulsants, and that are ultimately controlled by daily pharmacologic doses of pyridoxine (vitamin B6)." | 3.75 | Prevalence of ALDH7A1 mutations in 18 North American pyridoxine-dependent seizure (PDS) patients. ( Bennett, CL; Chen, Y; Glass, IA; Gospe, SM; Hahn, S, 2009) |
| "Folinic acid-responsive seizures and pyridoxine-dependent epilepsy are two treatable causes of neonatal epileptic encephalopathy." | 3.75 | Folinic acid-responsive seizures are identical to pyridoxine-dependent epilepsy. ( Gallagher, RC; Hyland, K; Jakobs, C; Mercimek-Mahmutoglu, S; Plecko, B; Rosenberg, EH; Salomons, GS; Scharer, G; Stockler-Ipsiroglu, S; Struys, EA; Van Hove, JL; Waters, PJ, 2009) |
| "Pyridoxine-dependent seizures are a rare condition recognized when numerous seizures respond to pyridoxine treatment and recur on pyridoxine withdrawal." | 3.74 | Pyridoxine-dependent seizures caused by alpha amino adipic semialdehyde dehydrogenase deficiency: the first polish case with confirmed biochemical and molecular pathology. ( Jakobs, C; Jozwiak, S; Kacinski, M; Kaczorowska, M; Kmiec, T; Kroczka, S; Salomons, GS; Struys, EA, 2008) |
| "Pyridoxine-dependent seizures (PDS) is a rare, autosomal recessively inherited disorder." | 3.74 | Pyridoxine-dependent seizures in Dutch patients: diagnosis by elevated urinary alpha-aminoadipic semialdehyde levels. ( Been, JV; Bok, LA; Jakobs, C; Struys, E; Willemsen, MA, 2007) |
| "Pyridoxine-responsive seizures (PRS) and the role of pyridoxine (PN, vitamin B(6)) in hypophosphatasia (HPP) are incompletely understood." | 3.74 | Pyridoxine-responsive seizures as the first symptom of infantile hypophosphatasia caused by two novel missense mutations (c.677T>C, p.M226T; c.1112C>T, p.T371I) of the tissue-nonspecific alkaline phosphatase gene. ( Baumgartner-Sigl, S; Ericson, KL; Haberlandt, E; Högler, W; Mumm, S; Ryan, L; Scholl-Bürgi, S; Sergi, C; Whyte, MP, 2007) |
| "Pyridoxine dependent seizure (PDS) is a disorder of neonates or infants with autosomal recessive inheritance characterized by seizures, which responds to pharmacological dose of pyridoxine." | 3.74 | Allelic and non-allelic heterogeneities in pyridoxine dependent seizures revealed by ALDH7A1 mutational analysis. ( Aoki, Y; Baumeister, FA; Goto, T; Haginoya, K; Hasegawa, Y; Hoshino, H; Kamada, F; Kanno, J; Kure, S; Matsubara, Y; Narisawa, A; Takahashi, T; Takayanagi, M; Tsuchiya, S; Yamaguchi, S; Yamamoto, K, 2007) |
| "The rare autosomal recessive disorder pyridoxine 5'-phosphate oxidase (PNPO) deficiency is a recently described cause of neonatal and infantile seizures." | 3.74 | PNPO deficiency: an under diagnosed inborn error of pyridoxine metabolism. ( Elisha, MB; Falik-Zaccai, TC; Frankel, P; Hershckowitz, S; Khayat, M; Korman, SH; Sheffer, VF; Weintraub, Z; Wevers, RA, 2008) |
| "To study the difference between pyridoxine (PN) and its active form, pyridoxal phosphate, (PLP) in control of idiopathic intractable epilepsy in children." | 3.73 | Pyridoxal phosphate is better than pyridoxine for controlling idiopathic intractable epilepsy. ( Chang, MY; Chou, ML; Hsieh, MY; Hung, PC; Kuo, MF; Lin, KL; Wang, HS, 2005) |
| "Both isoniazid (INH) and cefazolin (CEZ) can have serious adverse effects on the central nervous system (CNS), causing seizures." | 3.73 | Effect of isoniazid on the pharmacodynamics of cefazolin-induced seizures in rats. ( Ishiwata, Y; Nagata, M; Yasuhara, M, 2005) |
| " Acute isoniazid intoxication is characterized by a clinical triad consisting of metabolic acidosis resistant to treatment with sodium bicarbonate, seizures which may be fatal and refractory to standard anticonvulsant therapy, and coma." | 3.73 | Seizures, metabolic acidosis and coma resulting from acute isoniazid intoxication. ( Ekici, NZ; Kefi, A; Sakarya, M; Topcu, I; Yentur, EA, 2005) |
| "Determine the prevalence of pyridoxine dependent seizures in children less than 16 years of age attending a teaching hospital in south India with early onset (before 3 years) intractable epilepsy of unknown aetiology, using the criteria proposed by Baxter." | 3.73 | Prevalence of pyridoxine dependent seizures in south Indian children with early onset intractable epilepsy: A hospital based prospective study. ( Parameswaran, M; Ramachandrannair, R, 2005) |
| "We show here that children with pyridoxine-dependent seizures (PDS) have mutations in the ALDH7A1 gene, which encodes antiquitin; these mutations abolish the activity of antiquitin as a delta1-piperideine-6-carboxylate (P6C)-alpha-aminoadipic semialdehyde (alpha-AASA) dehydrogenase." | 3.73 | Mutations in antiquitin in individuals with pyridoxine-dependent seizures. ( Baumgartner, M; Baxter, P; Clayton, PT; Jakobs, C; Mills, PB; Omran, H; Plecko, B; Struys, E; Tacke, U; Uhlenberg, B; Weschke, B; Willemsen, MA, 2006) |
| "Pyridoxine-dependent seizures is an autosomal, recessively inherited inborn error of metabolism with recurrent long-lasting seizures with onset usually in infancy, but also up to three years of age." | 3.72 | [Pyridoxine-dependent seizures]. ( Akre, B; Lundby, R; Rasmussen, M, 2004) |
| "Pyridoxine dependency is a rare autosomal-recessive disorder causing intractable seizures in neonates and infants." | 3.72 | Pyridoxine-dependent seizures and microcephaly. ( Büyükavci, M; Karakelleoğlu, C; Kardaş, F; Tan, H, 2004) |
| "We previously identified vitamin B6 deficiency in a child presenting with seizures whose primary diagnosis was the inherited disorder hyperprolinemia type II." | 3.71 | Pyridoxal phosphate de-activation by pyrroline-5-carboxylic acid. Increased risk of vitamin B6 deficiency and seizures in hyperprolinemia type II. ( Farrant, RD; Langley, GJ; Mellor, JM; Mills, GA; Walker, V, 2001) |
| "Several lines of evidence suggest that the binding affinity of glutamate decarboxylase (GAD) to the active form of pyridoxine is low in cases of pyridoxine-dependent seizures (PDS) and that a quantitative imbalance between excitatory (i." | 3.71 | CSF glutamate/GABA concentrations in pyridoxine-dependent seizures: etiology of pyridoxine-dependent seizures and the mechanisms of pyridoxine action in seizure control. ( Goto, T; Matsuo, N; Takahashi, T, 2001) |
| "Pyridoxine dependency and congenital hypophosphatasia are unusual metabolic disorders." | 3.71 | Pyridoxine-dependent seizures associated with hypophosphatasia in a newborn. ( Bica, I; Fiori, RM; Mugnol, F; Nunes, ML, 2002) |
| "Isoniazid-induced seizures respond poorly to anticonvulsants but well to pyridoxine (Vitamin B6); theophylline produces difficult-to-treat seizures with substantial morbidity and mortality." | 3.70 | Seizures induced by theophylline and isoniazid in mice. ( Bonner, AB; Peterson, SL; Weir, MR, 1999) |
| "To study the epidemiology of pyridoxine dependent seizures and other forms of pyridoxine responsive seizures." | 3.70 | Epidemiology of pyridoxine dependent and pyridoxine responsive seizures in the UK. ( Baxter, P, 1999) |
| " The effects of systemic pretreatment with hydrocortisone (5-25 mg/kg), pyridoxine (20-250 mg/kg), and sodium valproate (VPA; 200 and 400 mg/kg) against the NMDA-induced automatisms, emprosthotonic (hyperflexion), and clonic-tonic seizures were determined." | 3.70 | Age-specific N-methyl-D-aspartate-induced seizures: perspectives for the West syndrome model. ( Kábová, R; Liptáková, S; Pometlová, M; Slamberová, R; Velísek, L, 1999) |
| "A newborn girl with seizures was, after repeated conventional anticonvulsive treatment, cured by pyridoxine administration." | 3.69 | [Pyridoxine-dependent epilepsy in an infant]. ( Bosschaart, AN; Hageman, G; Tummers, RF; van Waarde, WM, 1995) |
| "An 18-year-old man was treated from birth with chronic high dose pyridoxine (vitamin B6) up to 2000 mg per day for pyridoxine-dependent seizures." | 3.69 | Pyridoxine dependent epilepsy with iatrogenic sensory neuronopathy. ( Brown, WF; McLachlan, RS, 1995) |
| "Pyridoxine-dependent seizures are a disorder of GABA metabolism probably due to a defective binding of pyridoxal phosphate coenzyme (PALP) with glutamate decarboxylase (GAD), the rate-limiting enzyme in GABA synthesis." | 3.69 | Pyridoxine-dependent seizures associated with white matter abnormalities. ( Giugliani, R; Jardim, LB; Kliemann, FA; Martins, CE; Pires, RF; Vargas, CR; Vizioli, J, 1994) |
| "An abnormality in the pyridoxal-5'-phosphate (PLP) dependent enzyme, glutamic acid decarboxylase (GAD), which synthesizes gamma-aminobutyric acid (GABA), may underlie the epileptic syndrome of pyridoxine-dependent seizures." | 3.69 | Reduced GABA synthesis in pyridoxine-dependent seizures. ( Gospe, SM; Keen, CL; Olin, KL, 1994) |
| "Theophylline-induced seizures have significant morbidity and mortality and are difficult to treat." | 3.69 | Pyridoxine as therapy in theophylline-induced seizures. ( Glenn, GM; Kelly, P; Krober, MS; McCarty, J; Weir, M, 1995) |
| "To report a case of reversible seizures and mental status changes in a dialysis patient given preventive isoniazid therapy." | 3.68 | Reversible seizures and mental status changes in a dialysis patient on isoniazid preventive therapy. ( Asnis, DS; Bhat, JG; Melchert, AF, 1993) |
| "In an infant with typical pyridoxine-dependent seizures, CSF GABA level, was determined before treatment with pyridoxine." | 3.68 | Disturbance of GABA metabolism in pyridoxine-dependent seizures. ( Bömelburg, T; Grüneberg, M; Kurlemann, G; Palm, DG; Ullrich, K; Ziegler, R, 1992) |
| "A Japanese girl with atypical pyridoxine-dependent seizures is reported." | 3.68 | Pyridoxine-dependent seizures: report of a case with atypical clinical features and abnormal MRI scans. ( Arima, J; Momoi, T; Okumura, M; Tanaka, R; Yamakura, S, 1992) |
| "A patient of pyridoxine dependent seizures was reported." | 3.68 | [Chronological change of EEG findings in a case of pyridoxine dependency seizures]. ( Abe, J; Futagi, Y; Koga, R; Otani, K; Takeuchi, T; Yabuuchi, H, 1990) |
| "Blood-brain barrier (BBB) permeability to macromolecules was assessed during seizures induced by pentylenetetrazole, bicuculline, methoxypyridoxine, methionine sulfoximine, and kainic acid." | 3.67 | Pathophysiological aspects of blood-brain barrier permeability in epileptic seizures. ( Goping, G; Klatzo, I; Nitsch, C, 1986) |
| " Methionine restriction initiated neonatally prevented mental retardation, retarded the rate of lens dislocation, and may have reduced the incidence of seizures." | 3.67 | The natural history of homocystinuria due to cystathionine beta-synthase deficiency. ( Andria, G; Boers, GH; Bromberg, IL; Cerone, R; Levy, HL; Mudd, SH; Pettigrew, KD; Pyeritz, RE; Skovby, F; Wilcken, B, 1985) |
| "In rabbits, generalized seizures were induced by methoxypyridoxine, and changes in amino acid concentrations of 15 brain regions were investigated before seizure onset and during the course of sustained epileptiform activity." | 3.66 | Alterations in the content of amino acid neurotransmitters before the onset and during the course of methoxypyridoxine-induced seizures in individual rabbit brain regions. ( Haug, P; Nitsch, C; Schmude, B, 1983) |
| "The effects of pyridoxal phosphate, pyridoxine and hydrazine were studied on homocysteine-induced seizures in mice." | 3.66 | Homocysteine induced convulsions: enhancement by vitamin B6 and inhibition by hydrazine. ( Hammond, EJ; Hurd, RW; Wilder, BJ, 1981) |
| "Large doses of pyridoxine recently have been shown to prevent the seizures and acidosis caused by ingestion of more than two to three grams of isoniazid." | 3.66 | Isoniazid overdose treated with high-dose pyridoxine. ( Wood, JP; Yarbrough, BE, 1983) |
| "Pyridoxine-dependent seizures occur as a result of an increased requirement of the vitamin within the central nervous system." | 3.66 | Pyridoxine-dependent seizures. ( Crowell, GF; Roach, ES, 1983) |
| "We report 4 infants with pyridoxine dependent seizures who had clinical features that led to diagnostic uncertainty." | 3.66 | Pyridoxine dependent seizures--a wider clinical spectrum. ( Bankier, A; Hopkins, IJ; Turner, M, 1983) |
| "High pressure oxygen (HBO) and 1,1-dimethylhydrazine (UDMH) both cause grand mal seizures, brain glycogen degradation, and inhibition of glutamic acid decarboxylase (GAD)." | 3.66 | Alterations in seizure mechanisms caused by oxygen high pressure, 1,1-dimethylhydrazine, and pyridoxine. ( Segerbo, BE, 1979) |
| "In rabbits epileptiform seizures were induced by systemic application of methoxypyridoxine, an antimetabolite of vitamin B6." | 3.65 | Antivitamin B6 induced ultrastructural changes in the hippocampus of the convulsant rabbit and its biochemical correlates. ( Nitsch, C, 1976) |
| "The effects of pyridoxine deficiency and the administration of supplemental vitamin B6 on audiogenic and electroconvulsive seizures were studied in two inbred strains of mice and their F1 hybrids." | 3.65 | Levels of pyridoxine and susceptibility to electroconvulsive and audiogenic seizures. ( Lieff, B; Schlesinger, K, 1975) |
| "Vigabatrin is the treatment of choice when the underlying cause is tuberous sclerosis complex (TSC)." | 2.53 | Improving Outcomes in Infantile Spasms: Role of Pharmacotherapy. ( Appleton, R; Iyer, A, 2016) |
| "Among these, pyridoxine-dependent seizures due to antiquitin deficiency is by far the most common, although exact incidence data are lacking." | 2.49 | Pyridoxine and pyridoxalphosphate-dependent epilepsies. ( Plecko, B, 2013) |
| "However, specific types of seizures, such as myoclonic seizures or distinctive electroencephalographic patterns, such as suppression burst patterns, epileptic syndrome or early myoclonic encephalopathy, may suggest a specific metabolic disease." | 2.43 | [Neonatal epilepsy and inborn errors of metabolism]. ( Bahi-Buisson, N; de Lonlay, P; Desguerre, I; Dulac, O; Kaminska, A; Léger, PL; Mention, K; Nabbout, R; Plouin, P; Valayanopoulos, V, 2006) |
| "Isoniazid overdose is a potentially fatal intoxication." | 2.39 | Isoniazid overdose: four case reports and review of the literature. ( Alvarez, FG; Guntupalli, KK, 1995) |
| "Isoniazid has a low therapeutic margin and produces life threatening signs in dogs ingesting single 300 mg human tablets." | 2.39 | Treatment of acute isoniazid overdose in dogs. ( Barret, GH; Buck, WB; Holding, J; Knight, MK; Villar, D, 1995) |
| "Pyridoxine-dependency is a rare autosomal recessive disorder causing a severe seizure disorder of prenatal or neonatal onset, psychomotor retardation and death in untreated patients." | 2.38 | Pyridoxine-dependent seizures, clinical and therapeutic aspects. ( Girardin, E; Haenggeli, CA; Paunier, L, 1991) |
| " Is pyridoxine safe for long-term use in large segments of the population, including children? The studies on children with Down's syndrome and autism, utilizing much higher doses than are used for other therapeutic purposes, seem to indicate relative safety if carefully monitored." | 2.38 | Vitamin B6 in clinical neurology. ( Bernstein, AL, 1990) |
| "Neonatal seizures, as distinguished from nonconvulsive abnormal movements, are a significant problem in neonatal intensive care units." | 2.37 | Neonatal seizures. ( Bergman, I; Crumrine, P; Painter, MJ, 1986) |
| "About 7/18 (39%) of patients showed seizure-free with pyridoxine (PN) or pyridoxal-5'-phosphate treatment." | 1.91 | Analysis for variable manifestations and molecular characteristics of pyridox(am)ine-5'-phosphate oxidase (PNPO) deficiency. ( Gong, P; Jiao, X; Niu, Y; Xu, Z; Yang, Z; Zhang, Y, 2023) |
| " However, the adverse effects, including nausea and peripheral sensory neuropathy, caused by long-term and high-dose consumption of vitamin B6 have undermined the usefulness of vitamin B6 supplementation, justifying additional experimental scrutiny of vitamin B6-associated toxicity." | 1.56 | Increased leptin-b expression and metalloprotease expression contributed to the pyridoxine-associated toxicity in zebrafish larvae displaying seizure-like behavior. ( Chang, AY; Chang, HH; Chen, BH; Chen, PY; Fu, TF; Hsiao, YH; Huang, CW; Sung, PS; Tsai, YW, 2020) |
| "The most common type of seizure was generalized tonic-clonic in 7 patients and the most common EEG pattern was characterized by a "burst suppression" pattern." | 1.48 | Pyridoxine-dependent epilepsies: an observational study on clinical, diagnostic, therapeutic and prognostic features in a pediatric cohort. ( Burlina, A; Capovilla, G; De Liso, P; Falsaperla, R; Leuzzi, V; Marchiani, V; Mastrangelo, M; Murgia, A; Sartori, S; Striano, P; Suppiej, A; Toldo, I; Vari, MS; Vecchi, M; Vitaliti, G, 2018) |
| "Seizures are typically not responsive to conventional antiepileptic drugs, but they cease after parental pyridoxine administration." | 1.46 | Pyridoxine dependent epilepsies: new therapeutical point of view. ( Corsello, G; Falsaperla, R, 2017) |
| "She had no recurrence of seizures but had acute liver injury subsequently which gradually improved with supportive care." | 1.46 | Oral pyridoxine can substitute for intravenous pyridoxine in managing patients with severe poisoning with isoniazid and rifampicin fixed dose combination tablets: a case report. ( Dilrukshi, MDSA; Gnanathasan, CA; Ratnayake, CAP, 2017) |
| "Hypophosphatasia is a rare inherited disorder of bone and mineral metabolism caused by a number of loss-of-function mutations in the ALPL gene." | 1.43 | Pyridoxine-Responsive Seizures in Infantile Hypophosphatasia and a Novel Homozygous Mutation in ALPL Gene. ( Bircan, İ; Çelmeli, G; Güzel Nur, B; Manguoğlu, E; Mıhçı, E; Soyucen, E, 2016) |
| "We report a case of isoniazid induced convulsions in 35 years old male alcoholic and smoker patient receiving intensive phase therapy for pulmonary tuberculosis." | 1.42 | Isoniazid induced convulsions at therapeutic dose in an alcoholic and smoker patient. ( Aiwale, AS; Barvaliya, MJ; Jha, PR; Patel, UA; Tripathi, C, 2015) |
| "Pyridoxal phosphate was extremely high in CSF and plasma." | 1.40 | Infantile hypophosphatasia without bone deformities presenting with severe pyridoxine-resistant seizures. ( Abeling, NGGM; Bosch, AM; Cobben, JM; de Roo, MGA; Duran, M; Koelman, JHTM; Majoie, CB; Poll-The, BT, 2014) |
| "This seizure-like swimming pattern was alleviated by the addition of either pyridoxal-5'-phosphate (PLP) or GABA and responded quickly to the anti-convulsing activity of gabapentin and phenytoin, two commonly prescribed anti-epileptic drugs (AEDs)." | 1.38 | Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5'-phosphate, GABA and anti-epileptic drugs. ( Chang, WN; Du, HC; Fu, TF; Hsiao, TH; Kao, TT; Lee, GH; Safo, MK; Sung, SY, 2012) |
| "Toxin-related seizures result from an imbalance in the brain's equilibrium of excitation-inhibition." | 1.37 | Toxin-related seizures. ( Hoffman, RJ; Sharma, AN, 2011) |
| "Neonatal seizures are one of the most common neurological disorders in infants." | 1.35 | Neonatal seizures: treatment and treatment variability in 31 United States pediatric hospitals. ( Blume, HK; Christakis, DA; Garrison, MM, 2009) |
| "Pyridoxine was given intravenously as an antidote." | 1.34 | [Isoniazid intoxication]. ( Cyran, J; Graf, J; Radunz, W; Scheffold, N, 2007) |
| "Pyridoxine-dependent seizure (PDS) is a rare autosomal recessive intractable seizure disorder only controlled by a daily supplementation of pharmacological doses of pyridoxine (Vitamin B6)." | 1.33 | Genetic heterogeneity for autosomal recessive pyridoxine-dependent seizures. ( Bennett, CL; Chance, PF; Glass, IA; Gospe, SM; Huynh, HM, 2005) |
| "Pyridoxine is a recommended antidote that should be available in emergency departments (EDs)." | 1.33 | Hospital pharmacy and emergency department availability of parenteral pyridoxine. ( Bell, RM; Gospe, SM, 2005) |
| "There was no difference in onset of seizure time between the pyridoxine-treated group of rats and the control rats." | 1.33 | Pyridoxine does not prevent hyperbaric oxygen-induced seizures in rats. ( Cameron, D; Chase, PB; Fernandez, MC; Roe, DJ; Walter, FG; Wolfson, M, 2006) |
| "Pyridoxine-dependency is a rare autosomal recessive disorder causing a severe seizure disorder of neonatal onset." | 1.31 | Pyridoxine-dependent seizures: long-term follow-up of two cases with clinical and MRI findings, and pyridoxine treatment. ( Müngen, B; Ulvi, H; Yakinci, C; Yoldaş, T, 2002) |
| "In contrast, motor seizures were rare, seen only in 18 day old rats (250 mg/kg of B6)." | 1.30 | Proconvulsant effects induced by pyridoxine in young rats. ( Kábová, R; Velísek, L; Veresová, S, 1998) |
| "One patient presented twice with seizures." | 1.29 | Acute isoniazid neurotoxicity in an urban hospital. ( Santucci, K; Shah, BR; Sinert, R; Steiner, P, 1995) |
| "They also exhibited severe seizure discharge activity of prolonged duration at any given dose of either picrotoxin or pentylene tetrazole." | 1.29 | Picrotoxin and pentylene tetrazole induced seizure activity in pyridoxine-deficient rats. ( Bolster, B; Dakshinamurti, K; Sharma, SK, 1994) |
| "She was in respiratory failure, with seizures that could not be stopped with diazepam." | 1.29 | [Pyridoxine for severe metabolic acidosis and seizures due to isoniazid overdose]. ( Adler, M; Girsh-Solomonovich, Z; Raikhlin-Eisenkraft, B, 1993) |
| "The results suggest that audiogenic seizures in magnesium-deficient mice form a model of magnesium depletion." | 1.29 | Audiogenic seizures in magnesium-deficient mice: effects of magnesium pyrrolidone-2-carboxylate, magnesium acetyltaurinate, magnesium chloride and vitamin B-6. ( Bac, P; Binet, P; Durlach, J; Herrenknecht, C, 1993) |
| " The dosage of pyridoxine should be optimal for IQ as well as seizure control." | 1.29 | Pyridoxine-dependent seizures: demographic, clinical, MRI and psychometric features, and effect of dose on intelligence quotient. ( Baxter, P; Gardner-Medwin, D; Griffiths, P; Kelly, T, 1996) |
| "The results are as follows: 1." | 1.28 | [The effect of acupuncture on high oxygen pressure-induced convulsion and its relationship to the brain GABA concentration in mice]. ( Shen, Q; Wu, Y; Zhang, Q, 1992) |
| "Compared to the preconvulsion group, the total free amino acid level increased in the ACTH group clearly." | 1.27 | Amino acid metabolism in the brain with convulsive disorders. Part 2: The effects of anticonvulsants on convulsions and free amino acid patterns in the brain of El mouse. ( Honda, T, 1984) |
| "A child developed minor motor seizures at the age of 14 months accompanied by an abnormal electroencephalogram showing single spikes and polyspikes over the vertex and frontocentral regions." | 1.27 | Pyridoxine-dependency seizure: report of a rare presentation. ( Krishnamoorthy, KS, 1983) |
| "In an infant with neonatal seizures, CSF GABA levels were determined before and after treatment with vitamin B6." | 1.27 | Disappearance of neonatal seizures and low CSF GABA levels after treatment with vitamin B6. ( Dominick, HC; Kurlemann, G; Löscher, W; Palm, GD, 1987) |
| "Prominal reduced the severity of convulsions in pp'DDT-treated animals." | 1.26 | A possible neurochemical basis of the central stimulatory effects of pp'DDT. ( Jaffery, FN; Matin, MA; Siddiqui, RA, 1981) |
| "Seizures were induced by intravenous injection of 100 mg kg-1 methoxypyridoxine; 40 minutes later the animals were decapitated and discrete brain areas removed." | 1.26 | Selected ion monitoring determination of acetylcholine during methoxypyridoxine seizures. ( Haug, P; Nitsch, C; Schmude, B; Suzuki, M; Wunn, W, 1980) |
| "We treated five isoniazid-overdosed patients each with a single dose of pyridoxine hydrochloride equivalent to the gram amount of isoniazid ingested and compared their outcome with that of 41 patients from the literature who received little or no pyridoxine." | 1.26 | Single high-dose pyridoxine treatment for isoniazid overdose. ( Lacouture, PG; Lovejoy, FH; Wason, S, 1981) |
| "During epileptiform seizures, however, the size and shape of clear and dense-core vesicles varied greatly." | 1.26 | Large dense-core vesicle exocytosis and membrane recycling in the mossy fibre synapses of the rabbit hippocampus during epileptiform seizures. ( Nitsch, C; Rinne, U, 1981) |
| "The onset of convulsions induced by these convulsants coincides with the fall in GABA content and GAD activity in the mesencephalon area, and in contrast, the cessation of the convulsions by PN supplement coincides with the recovery in both the parameters." | 1.26 | Effect of antivitamin B6 on regional GABA metabolism in mouse brain and its relation to convulsions. ( Abe, M; Matsuda, M, 1979) |
| "During the convulsions by TSC 16hr after the AOAA-pretreatment, the GABA content in synaptosomes was less than that from the group treated with AOAA alone, though its GABA level was higher than the normal level." | 1.26 | Relationship between gamma-aminobutyric acid metabolism and antivitamin B6-induced convulsions. ( Abe, M, 1978) |
| "In mice, the ED(50) values for seizures following intraperitoneal injection were allylglycine 1." | 1.25 | Seizures induced by allylglycine, 3-mercaptopropionic acid and 4-deoxypyridoxine in mice and photosensitive baboons, and different modes of inhibition of cerebral glutamic acid decarboxylase. ( Horton, RW; Meldrum, BS, 1973) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 172 (55.48) | 18.7374 |
| 1990's | 42 (13.55) | 18.2507 |
| 2000's | 47 (15.16) | 29.6817 |
| 2010's | 38 (12.26) | 24.3611 |
| 2020's | 11 (3.55) | 2.80 |
| Authors | Studies |
|---|---|
| Bayat, A | 1 |
| Aledo-Serrano, A | 1 |
| Gil-Nagel, A | 1 |
| Korff, CM | 1 |
| Thomas, A | 1 |
| Boßelmann, C | 1 |
| Weber, Y | 1 |
| Gardella, E | 1 |
| Lund, AM | 1 |
| de Sain-van der Velden, MGM | 1 |
| Møller, RS | 1 |
| Tsao, HS | 1 |
| Case, SD | 1 |
| Coughlin, CR | 2 |
| Tseng, LA | 2 |
| van Karnebeek, CDM | 3 |
| Hoytema van Konijnenburg, EMM | 1 |
| Longo, N | 1 |
| Andrews, A | 1 |
| van Wegberg, A | 1 |
| Coene, KLM | 1 |
| Jiao, X | 1 |
| Gong, P | 1 |
| Niu, Y | 1 |
| Xu, Z | 1 |
| Zhang, Y | 1 |
| Yang, Z | 1 |
| Crowther, LM | 1 |
| Poms, M | 1 |
| Zandl-Lang, M | 1 |
| Abela, L | 2 |
| Hartmann, H | 1 |
| Seiler, M | 1 |
| Mathis, D | 1 |
| Plecko, B | 5 |
| İpek, R | 1 |
| Çavdartepe, BE | 1 |
| Kor, D | 1 |
| Okuyaz, Ç | 1 |
| Fortin, O | 1 |
| Christoffel, K | 1 |
| Kousa, Y | 1 |
| Miller, I | 1 |
| Leon, E | 1 |
| Donoho, K | 1 |
| Mulkey, SB | 1 |
| Anwar, T | 1 |
| Garcia-Ezquiaga, J | 1 |
| Carrasco-Marina, ML | 1 |
| Gutierrez-Cruz, N | 1 |
| Iglesias-Escalera, G | 1 |
| Castro-Reguera, M | 1 |
| Perez-Gonzalez, B | 1 |
| Chen, PY | 1 |
| Tsai, YW | 1 |
| Chang, AY | 1 |
| Chang, HH | 1 |
| Hsiao, YH | 1 |
| Huang, CW | 1 |
| Sung, PS | 1 |
| Chen, BH | 1 |
| Fu, TF | 2 |
| Tanigawa, J | 1 |
| Nabatame, S | 1 |
| Tominaga, K | 1 |
| Nishimura, Y | 1 |
| Maegaki, Y | 1 |
| Kinosita, T | 1 |
| Murakami, Y | 3 |
| Ozono, K | 1 |
| Polat, E | 1 |
| Senel, S | 1 |
| Lopez-Marin, L | 1 |
| Falsaperla, R | 3 |
| Corsello, G | 1 |
| Dilrukshi, MDSA | 1 |
| Ratnayake, CAP | 1 |
| Gnanathasan, CA | 1 |
| di Salvo, ML | 1 |
| Mastrangelo, M | 2 |
| Nogués, I | 1 |
| Tolve, M | 1 |
| Paiardini, A | 1 |
| Carducci, C | 1 |
| Mei, D | 1 |
| Montomoli, M | 1 |
| Tramonti, A | 1 |
| Guerrini, R | 1 |
| Contestabile, R | 1 |
| Leuzzi, V | 2 |
| Pena, IA | 1 |
| Roussel, Y | 1 |
| Daniel, K | 1 |
| Mongeon, K | 1 |
| Johnstone, D | 1 |
| Weinschutz Mendes, H | 1 |
| Bosma, M | 1 |
| Saxena, V | 1 |
| Lepage, N | 1 |
| Chakraborty, P | 1 |
| Dyment, DA | 1 |
| Verhoeven-Duif, N | 1 |
| Bui, TV | 1 |
| Boycott, KM | 1 |
| Ekker, M | 1 |
| MacKenzie, A | 1 |
| Accorsi, P | 1 |
| Cellini, E | 1 |
| Paolantonio, CD | 1 |
| Panzarino, G | 1 |
| Verrotti, A | 1 |
| Giordano, L | 2 |
| Vari, MS | 1 |
| Toldo, I | 1 |
| Murgia, A | 1 |
| Sartori, S | 1 |
| Vecchi, M | 1 |
| Suppiej, A | 1 |
| Burlina, A | 1 |
| Marchiani, V | 1 |
| De Liso, P | 1 |
| Capovilla, G | 3 |
| Striano, P | 3 |
| Vitaliti, G | 1 |
| Glatstein, M | 1 |
| Carbell, G | 1 |
| Scolnik, D | 1 |
| Rimon, A | 1 |
| Banerji, S | 1 |
| Hoyte, C | 1 |
| Anderson, J | 1 |
| Arboleda, N | 1 |
| Calleo, V | 1 |
| Ishiguro, T | 1 |
| Sugiyama, Y | 1 |
| Ueda, K | 1 |
| Muramatsu, Y | 1 |
| Tsuda, H | 1 |
| Kotani, T | 1 |
| Michigami, T | 1 |
| Tachikawa, K | 1 |
| Akiyama, T | 1 |
| Hayakawa, M | 1 |
| Uzman, S | 1 |
| Uludağ Yanaral, T | 1 |
| Toptaş, M | 1 |
| Koç, A | 1 |
| Taş, A | 1 |
| Bican, G | 1 |
| de Roo, MGA | 1 |
| Abeling, NGGM | 1 |
| Majoie, CB | 1 |
| Bosch, AM | 1 |
| Koelman, JHTM | 1 |
| Cobben, JM | 1 |
| Duran, M | 1 |
| Poll-The, BT | 1 |
| Yang, ZX | 2 |
| Qin, J | 1 |
| Pearl, PL | 2 |
| Gospe, SM | 10 |
| Paul, K | 1 |
| Mills, P | 1 |
| Clayton, P | 1 |
| Paschke, E | 1 |
| Maier, O | 1 |
| Hasselmann, O | 1 |
| Schmiedel, G | 1 |
| Kanz, S | 1 |
| Connolly, M | 1 |
| Wolf, N | 1 |
| Struys, E | 4 |
| Stockler, S | 1 |
| Hofer, D | 1 |
| Tamaura, M | 1 |
| Shimbo, H | 1 |
| Iai, M | 1 |
| Yamashita, S | 1 |
| Osaka, H | 1 |
| Ware, TL | 1 |
| Pitt, J | 1 |
| Freeman, J | 1 |
| Aiwale, AS | 1 |
| Patel, UA | 1 |
| Barvaliya, MJ | 1 |
| Jha, PR | 1 |
| Tripathi, C | 1 |
| Tincheva, S | 1 |
| Todorov, T | 1 |
| Todorova, A | 1 |
| Georgieva, R | 1 |
| Stamatov, D | 1 |
| Yordanova, I | 1 |
| Kadiyska, T | 1 |
| Georgieva, B | 1 |
| Bojidarova, M | 1 |
| Tacheva, G | 1 |
| Litvinenko, I | 1 |
| Mitev, V | 1 |
| Dave, HN | 1 |
| Eugene Ramsay, R | 1 |
| Khan, F | 1 |
| Sabharwal, V | 1 |
| Irland, M | 1 |
| Güzel Nur, B | 1 |
| Çelmeli, G | 1 |
| Manguoğlu, E | 1 |
| Soyucen, E | 1 |
| Bircan, İ | 1 |
| Mıhçı, E | 1 |
| Xue, J | 1 |
| Li, H | 1 |
| Qian, P | 1 |
| Wu, Y | 2 |
| Jiang, YW | 1 |
| Liu, XY | 1 |
| Iyer, A | 1 |
| Appleton, R | 1 |
| Al Teneiji, A | 1 |
| Bruun, TU | 1 |
| Cordeiro, D | 1 |
| Patel, J | 1 |
| Inbar-Feigenberg, M | 1 |
| Weiss, S | 1 |
| Mercimek-Mahmutoglu, S | 2 |
| Been, JV | 3 |
| Bok, LA | 3 |
| Willemsen, MA | 4 |
| Struys, EA | 5 |
| Jakobs, C | 8 |
| Battaglia, S | 1 |
| Beccaria, F | 1 |
| Salomons, GS | 3 |
| Basura, GJ | 1 |
| Hagland, SP | 1 |
| Wiltse, AM | 1 |
| Kaczorowska, M | 1 |
| Kmiec, T | 1 |
| Kacinski, M | 1 |
| Kroczka, S | 1 |
| Jozwiak, S | 1 |
| Bennett, CL | 2 |
| Chen, Y | 1 |
| Hahn, S | 1 |
| Glass, IA | 2 |
| Gallagher, RC | 1 |
| Van Hove, JL | 1 |
| Scharer, G | 1 |
| Hyland, K | 1 |
| Waters, PJ | 1 |
| Stockler-Ipsiroglu, S | 1 |
| Rosenberg, EH | 1 |
| Blume, HK | 1 |
| Garrison, MM | 1 |
| Christakis, DA | 1 |
| Kabakus, N | 1 |
| Aydin, M | 1 |
| Ugur, SA | 1 |
| Durukan, M | 1 |
| Tolun, A | 1 |
| Davis, GP | 1 |
| McCarthy, JT | 1 |
| Magill, DB | 1 |
| Coffey, B | 1 |
| Rijper, EA | 1 |
| Tabarki, B | 1 |
| Thabet, F | 1 |
| Schmitt, B | 1 |
| Baumgartner, M | 2 |
| Mills, PB | 2 |
| Clayton, PT | 2 |
| Keller, E | 1 |
| Wohlrab, G | 1 |
| Uma Devi, P | 1 |
| Manocha, A | 1 |
| Khanam, R | 1 |
| Vohora, D | 1 |
| Mishra, D | 3 |
| Kalra, V | 1 |
| Seth, R | 1 |
| Gulati, S | 1 |
| Saha, N | 1 |
| Sharma, AN | 1 |
| Hoffman, RJ | 1 |
| Gerlach, AT | 1 |
| Thomas, S | 1 |
| Stawicki, SP | 1 |
| Whitmill, ML | 1 |
| Steinberg, SM | 1 |
| Cook, CH | 1 |
| Yeghiazaryan, NS | 1 |
| Zara, F | 1 |
| Brigati, G | 1 |
| Demirbilek, H | 1 |
| Alanay, Y | 1 |
| Alikaşifoğlu, A | 1 |
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| Yakinci, C | 1 |
| Yoldaş, T | 1 |
| Baxter, P | 7 |
| MOLONY, CJ | 1 |
| PARMELEE, AH | 1 |
| COURSIN, DB | 2 |
| HUNT, AD | 1 |
| STOKES, J | 1 |
| McCRORY, WW | 1 |
| STROUD, HH | 1 |
| PFEIFFER, CC | 1 |
| JENNEY, EH | 1 |
| MARSHALL, WH | 1 |
| BESSEY, OA | 1 |
| ADAM, DJ | 1 |
| HANSEN, AE | 1 |
| QUADBECK, G | 1 |
| SARTORI, GD | 1 |
| MARIE, J | 2 |
| HENNEQUET, A | 2 |
| LYON, G | 2 |
| DEBRIS, P | 2 |
| LE BALLE, JC | 2 |
| DENEVE, V | 1 |
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| SEGNI, G | 2 |
| GANDULLIA, E | 1 |
| KAMRIN, RP | 1 |
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| DE CASTRO DEL POZO, S | 1 |
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| SATO, M | 1 |
| WALDINGER, C | 2 |
| BERG, RB | 1 |
| STARKE, H | 1 |
| WILLIAMS, S | 1 |
| ZUNIN, C | 1 |
| VALLARINO, G | 1 |
| KOPELOFF, LM | 2 |
| CHUSID, JG | 2 |
| VERGA, G | 1 |
| HOTTINGER, A | 1 |
| BERGER, H | 1 |
| KRAUTHAMMER, W | 1 |
| ARCANGELI, A | 1 |
| O'BRIEN, RD | 1 |
| KIRKPATRICK, M | 1 |
| MILLER, PS | 1 |
| DAVANZO, JP | 1 |
| MATTHEWS, RJ | 1 |
| STAFFORD, JE | 1 |
| FRENCH, JH | 2 |
| GRUETER, BB | 1 |
| DRUCKMAN, R | 1 |
| O'BRIEN, D | 1 |
| MINARD, FN | 1 |
| KANG, CH | 1 |
| MUSHAHWAR, IK | 1 |
| DEVADATTA, S | 1 |
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| Bos, AF | 1 |
| Alffenaar, JW | 1 |
| Reijngoud, DJ | 1 |
| Brouwer, OF | 1 |
| Sival, DA | 1 |
| Kanno, J | 1 |
| Kure, S | 1 |
| Narisawa, A | 1 |
| Kamada, F | 1 |
| Takayanagi, M | 1 |
| Yamamoto, K | 1 |
| Hoshino, H | 1 |
| Goto, T | 2 |
| Takahashi, T | 2 |
| Haginoya, K | 1 |
| Tsuchiya, S | 1 |
| Baumeister, FA | 1 |
| Hasegawa, Y | 1 |
| Aoki, Y | 1 |
| Yamaguchi, S | 1 |
| Matsubara, Y | 1 |
| PILGRIM, FJ | 1 |
| PATTON, RA | 1 |
| Spasov, AA | 1 |
| Iezhitsa, IN | 1 |
| Kharitonova, MV | 1 |
| Kravchenko, MS | 1 |
| Khayat, M | 1 |
| Korman, SH | 1 |
| Frankel, P | 1 |
| Weintraub, Z | 1 |
| Hershckowitz, S | 1 |
| Sheffer, VF | 1 |
| Elisha, MB | 1 |
| Wevers, RA | 1 |
| Falik-Zaccai, TC | 1 |
| Bejsovec, M | 1 |
| Kulenda, Z | 1 |
| Ponca, E | 1 |
| Ressler, C | 1 |
| Nelson, J | 1 |
| Pfeffer, M | 1 |
| Walther, JU | 1 |
| Nitsch, C | 7 |
| Schmude, B | 2 |
| Haug, P | 3 |
| Firman, JD | 1 |
| Beck, MM | 1 |
| Hurd, RW | 1 |
| Hammond, EJ | 1 |
| Wilder, BJ | 1 |
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| Kawakami, K | 1 |
| Morita, E | 2 |
| Honda, T | 1 |
| Reynolds, RD | 1 |
| Yen-Koo, HC | 1 |
| Balazs, T | 1 |
| Yarbrough, BE | 1 |
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| Bachman, DS | 1 |
| Wilson, RG | 1 |
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| Silverstein, CI | 1 |
| Zingarelli, G | 1 |
| Schafer, EW | 1 |
| Silverstein, L | 1 |
| Fukumoto-Hato, M | 1 |
| Matsumoto-Yoshino, M | 1 |
| Crowell, GF | 1 |
| Roach, ES | 1 |
| Krishnamoorthy, KS | 1 |
| Bankier, A | 1 |
| Turner, M | 1 |
| Hopkins, IJ | 1 |
| Miller, J | 1 |
| Robinson, A | 1 |
| Percy, AK | 1 |
| McKiernan, J | 1 |
| Mellor, DH | 1 |
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| Shouse, MN | 1 |
| George, ME | 1 |
| Pinkerton, MK | 1 |
| Back, KC | 1 |
| Matin, MA | 3 |
| Jaffery, FN | 1 |
| Siddiqui, RA | 1 |
| Suzuki, M | 1 |
| Wunn, W | 1 |
| Wason, S | 1 |
| Lacouture, PG | 1 |
| Lovejoy, FH | 1 |
| Segerbo, B | 1 |
| Wood, ER | 1 |
| Rinne, U | 1 |
| Lahori, UC | 1 |
| Sharma, DB | 1 |
| Huff, MR | 1 |
| Johnson, WE | 1 |
| Meadows, GG | 1 |
| Minns, R | 1 |
| van Waarde, WM | 1 |
| Tummers, RF | 1 |
| Bosschaart, AN | 1 |
| Hageman, G | 1 |
| Blowey, DL | 1 |
| Johnson, D | 1 |
| Verjee, Z | 1 |
| Shah, BR | 1 |
| Santucci, K | 1 |
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| Steiner, P | 1 |
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| Brown, WF | 1 |
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| Pires, RF | 1 |
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| Vizioli, J | 1 |
| Kliemann, FA | 1 |
| Giugliani, R | 1 |
| Sharma, SK | 2 |
| Bolster, B | 2 |
| Dakshinamurti, K | 2 |
| Olin, KL | 1 |
| Keen, CL | 1 |
| McDonald, JW | 1 |
| Schoepp, DD | 1 |
| Adler, M | 1 |
| Girsh-Solomonovich, Z | 1 |
| Raikhlin-Eisenkraft, B | 1 |
| Bac, P | 1 |
| Herrenknecht, C | 1 |
| Binet, P | 1 |
| Durlach, J | 1 |
| Yagi, M | 1 |
| Wada, K | 3 |
| Sakata, M | 1 |
| Kokubo, M | 1 |
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| Asnis, DS | 1 |
| Bhat, JG | 1 |
| Melchert, AF | 1 |
| Alvarez, FG | 1 |
| Guntupalli, KK | 1 |
| Glenn, GM | 1 |
| Krober, MS | 1 |
| Kelly, P | 1 |
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| Villar, D | 1 |
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| Buck, WB | 1 |
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| Griffiths, P | 1 |
| Kelly, T | 1 |
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| Jiao, FY | 1 |
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| Takuma, Y | 1 |
| Wu, S | 1 |
| Liu, ZY | 1 |
| Zhang, XK | 1 |
| Lieu, NS | 1 |
| Ge, ZL | 1 |
| Chui, W | 1 |
| Li, HR | 1 |
| Cao, YM | 1 |
| Bai, AN | 1 |
| Liu, SB | 1 |
| Veresová, S | 1 |
| Kábová, R | 2 |
| Velísek, L | 2 |
| Ohro, Y | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Standardized Evaluation of Long-term Neurocognitive Development of Children From Age 3 With Pyridoxine Dependent Epilepsy by Antiquitine Deficiency[NCT06054347] | 30 participants (Anticipated) | Observational | 2023-11-01 | Not yet recruiting | |||
| Toxicological Screening by GC-MS Among Children Admitted for a First Afebrile Seizure (CASTox): a Pilot Study[NCT03310697] | 48 participants (Actual) | Interventional | 2017-12-19 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
30 reviews available for pyridoxine and Seizures
| Article | Year |
|---|---|
Pyridoxine-Dependent Epilepsy as a Cause of Neonatal Seizures.
Topics: Epilepsy; Humans; Infant, Newborn; Pyridoxine; Seizures | 2022 |
[Metabolic approach in epileptic encephalopathies in infants].
Topics: Age of Onset; Biotin; Brain Diseases, Metabolic; Brain Diseases, Metabolic, Inborn; Child, Preschool | 2017 |
Pyridoxine and pyridoxalphosphate-dependent epilepsies.
Topics: Brain Diseases, Metabolic; Child; Epilepsy; Humans; Hypoxia-Ischemia, Brain; Pyridoxaminephosphate O | 2013 |
[Advances in clinical and molecular genetic research on pyridoxine dependent epilepsy].
Topics: 2-Aminoadipic Acid; Aldehyde Dehydrogenase; Anticonvulsants; Biomarkers; Brain; DNA Mutational Analy | 2013 |
Improving Outcomes in Infantile Spasms: Role of Pharmacotherapy.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Humans; Infant; Pyridoxine; S | 2016 |
New treatment paradigms in neonatal metabolic epilepsies.
Topics: Brain Diseases, Metabolic, Inborn; Electroencephalography; Epilepsy; Humans; Infant, Newborn; Pyrido | 2009 |
Pyridoxine-dependent seizures: a clinical and biochemical conundrum.
Topics: Drug Overdose; gamma-Aminobutyric Acid; Humans; Pyridoxal Phosphate; Pyridoxine; Seizures | 2003 |
[PYRIDOXINE IN THE PATHOGENESIS AND THERAPY OF NEUROLOGIC AND PSYCHIATRIC DISEASES].
Topics: Alcoholism; Brain Diseases; Chorea; Extrapyramidal Tracts; Genetics, Medical; Humans; Intellectual D | 1963 |
[Neonatal epilepsy and inborn errors of metabolism].
Topics: Age Factors; Anticonvulsants; Biotin; Brain; Electroencephalography; Epilepsies, Myoclonic; Epilepsy | 2006 |
Pyridoxine-dependent seizures: new genetic and biochemical clues to help with diagnosis and treatment.
Topics: Biomarkers; Humans; Pipecolic Acids; Pyridoxine; Seizures; Vitamin B 6 Deficiency | 2006 |
Recent advances in amino acid and organic acid metabolism.
Topics: Acids; Amino Acids; Animals; Biochemistry; Glutamate-Ammonia Ligase; Humans; Nervous System Diseases | 2007 |
Isoniazid overdose: four case reports and review of the literature.
Topics: Acidosis; Adolescent; Adult; Antitubercular Agents; Drug Overdose; Female; Humans; Isoniazid; Male; | 1995 |
Treatment of acute isoniazid overdose in dogs.
Topics: Administration, Oral; Animals; Anticonvulsants; Antitubercular Agents; Cats; Diazepam; Dog Diseases; | 1995 |
[Pyridoxine dependency with seizures].
Topics: Amino Acid Metabolism, Inborn Errors; Brain; Diagnosis, Differential; gamma-Aminobutyric Acid; Gluta | 1998 |
Current perspectives on pyridoxine-dependent seizures.
Topics: Anticonvulsants; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; Infant; Infant, Newborn; | 1998 |
[Vitamin B6 dependency syndrome (vitamin B6 dependent seizures, convulsions)].
Topics: Biomarkers; Electroencephalography; gamma-Aminobutyric Acid; Humans; Infant, Newborn; Prognosis; Pyr | 1998 |
Acute isoniazid intoxication: seizures, acidosis and coma.
Topics: Acidosis; Acute Disease; Adolescent; Antitubercular Agents; Coma; Diagnosis, Differential; Drug Over | 1999 |
Pyridoxine-dependent and pyridoxine-responsive seizures.
Topics: Humans; Infant, Newborn; Magnetic Resonance Imaging; Metabolism, Inborn Errors; Molecular Biology; P | 2001 |
Disorders of glutamate metabolism.
Topics: Acetyltransferases; Amino-Acid N-Acetyltransferase; ATP-Binding Cassette Transporters; Bacterial Pro | 2001 |
[Pyridoxine related convulsive disorders].
Topics: Humans; Pyridoxine; Seizures; Substance-Related Disorders; Vitamin B 6 Deficiency | 2001 |
Pyridoxine-dependent seizures: a case report and a critical review of the literature.
Topics: Electroencephalography; Follow-Up Studies; Humans; Infant, Newborn; Magnetic Resonance Imaging; Male | 2001 |
Pyridoxine-dependent seizures: findings from recent studies pose new questions.
Topics: Humans; Metabolism, Inborn Errors; Pyridoxine; Seizures | 2002 |
Cytotoxicity of 3-hydroxykynurenine: implications for CNS damage in neonatal vitamin B-6 deficiency.
Topics: Animals; Animals, Newborn; Antioxidants; Brain; Brain Chemistry; Cell Death; Hybrid Cells; Hydrolase | 1991 |
Pyridoxine-dependent seizures, clinical and therapeutic aspects.
Topics: Female; Humans; Infant; Infant, Newborn; Intellectual Disability; Pyridoxine; Seizures | 1991 |
Vitamin B6 in clinical neurology.
Topics: Animals; Carpal Tunnel Syndrome; Chronic Disease; Depression; Headache; Humans; Movement Disorders; | 1990 |
Neurobiology of pyridoxine.
Topics: Animals; Brain; Endocrine Glands; Hypothalamus; Melatonin; Nervous System; Pineal Gland; Pituitary G | 1990 |
Neonatal seizures.
Topics: Adrenoleukodystrophy; Amino Acid Metabolism, Inborn Errors; Ammonia; Anesthetics, Local; Anticonvuls | 1986 |
[Scope and effect of vitamin B6 in newborn infants and children].
Topics: Amino Acids; Anemia, Hypochromic; Aspartate Aminotransferases; Brain; Coenzymes; Drug Antagonism; Fe | 1974 |
Pyridoxine dependency and central nervous system excitability.
Topics: Acoustic Stimulation; Aging; Aminobutyrates; Animals; Brain Chemistry; Drug Interactions; Electric S | 1972 |
Vitamin B6-dependency syndromes. New horizons in nutrition.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Aminobutyrates; Anemia, Sideroblastic; Animals; Child; | 1969 |
6 trials available for pyridoxine and Seizures
| Article | Year |
|---|---|
High-dose pyridoxine treatment for inherited glycosylphosphatidylinositol deficiency.
Topics: Adolescent; Child; Child, Preschool; Female; Glycosylphosphatidylinositols; Humans; Infant; Male; Ou | 2021 |
Efficacy of pyridoxine in early-onset idiopathic intractable seizures in children.
Topics: Anticonvulsants; Drug Therapy, Combination; Female; Humans; India; Infant; Longitudinal Studies; Mal | 2010 |
Pyridoxine induces non-specific EEG alterations in infants with therapy resistant seizures.
Topics: Electroencephalography; Female; Humans; Infant; Infant, Newborn; Male; Pyridoxine; Seizures; Statist | 2007 |
A controlled trial of pyridoxine supplementation in children with febrile convulsions.
Topics: 3-Hydroxyanthranilic Acid; Child, Preschool; Clinical Trials as Topic; Female; Humans; Infant; Kynur | 1981 |
Randomized, controlled trial of high-dose intravenous pyridoxine in the treatment of recurrent seizures in children.
Topics: Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Therapy, Combinatio | 1997 |
Intravenous pyridoxine-induced metabolic acidosis.
Topics: Acidosis; Adult; Antidotes; Antitubercular Agents; Blood Gas Analysis; Cross-Over Studies; Drug Moni | 2001 |
274 other studies available for pyridoxine and Seizures
| Article | Year |
|---|---|
Pyridoxine or pyridoxal-5-phosphate treatment for seizures in glycosylphosphatidylinositol deficiency: A cohort study.
Topics: Cohort Studies; Drug Resistant Epilepsy; Epilepsy; Female; Glycosylphosphatidylinositols; Humans; In | 2022 |
A case for newborn screening for pyridoxine-dependent epilepsy.
Topics: Aldehyde Dehydrogenase; Epilepsy; Humans; Infant, Newborn; Neonatal Screening; Pyridoxine; Seizures | 2022 |
Clinical Reasoning: Pediatric Seizures of Unknown Cause.
Topics: Aldehyde Dehydrogenase; Anticonvulsants; Child, Preschool; Clinical Reasoning; Female; Humans; Infan | 2022 |
Analysis for variable manifestations and molecular characteristics of pyridox(am)ine-5'-phosphate oxidase (PNPO) deficiency.
Topics: Brain Diseases, Metabolic; Humans; Hypoxia-Ischemia, Brain; Metabolic Diseases; Oxidoreductases; Pho | 2023 |
Metabolomics analysis of antiquitin deficiency in cultured human cells and plasma: Relevance to pyridoxine-dependent epilepsy.
Topics: Aldehyde Dehydrogenase; Epilepsy; Humans; Lysine; Metabolomics; Pyridoxine; Seizures | 2023 |
Pyridoxine-dependent Epilepsy caused by a Novel homozygous mutation in PLPBP Gene.
Topics: Aldehyde Dehydrogenase; Anticonvulsants; Child, Preschool; Epilepsy; Female; Homozygote; Humans; Inf | 2022 |
Pearls & Oy-sters: Delayed Response to Pyridoxine in Pyridoxine-Dependent Epilepsy.
Topics: Aldehyde Dehydrogenase; Epilepsy; Humans; Infant, Newborn; Pyridoxine; Seizures; Vitamin B 6 | 2023 |
[Pyridoxine-dependent epilepsy due to deficiency in the PNPO gene].
Topics: Adolescent; Brain Diseases, Metabolic; Chromosomes, Human, Pair 17; Epilepsy; Female; Humans; Hypoxi | 2019 |
Increased leptin-b expression and metalloprotease expression contributed to the pyridoxine-associated toxicity in zebrafish larvae displaying seizure-like behavior.
Topics: Animals; Animals, Genetically Modified; Dose-Response Relationship, Drug; Gene Expression Regulation | 2020 |
Suicide attempt with isoniazid in adolescents receiving tuberculous prophylaxis: three cases.
Topics: Adolescent; Antitubercular Agents; Child; Humans; Isoniazid; Pyridoxine; Seizures; Suicide, Attempte | 2021 |
Pyridoxine dependent epilepsies: new therapeutical point of view.
Topics: Anticonvulsants; Brain Diseases, Metabolic; Child, Preschool; Electroencephalography; Epilepsy; Fema | 2017 |
Oral pyridoxine can substitute for intravenous pyridoxine in managing patients with severe poisoning with isoniazid and rifampicin fixed dose combination tablets: a case report.
Topics: Administration, Oral; Antidotes; Antitubercular Agents; Diazepam; Drug Combinations; Female; Humans; | 2017 |
Pyridoxine-5'-phosphate oxidase (Pnpo) deficiency: Clinical and biochemical alterations associated with the C.347g>A (P.·Arg116gln) mutation.
Topics: Brain Diseases, Metabolic; Child, Preschool; Female; Humans; Hypoxia-Ischemia, Brain; Infant; Male; | 2017 |
Pyridoxine-Dependent Epilepsy in Zebrafish Caused by Aldh7a1 Deficiency.
Topics: Aldehyde Dehydrogenase; Animals; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Gene Kno | 2017 |
Pyridoxine responsiveness in pyridox(am)ine-5-phosphate oxidase deficiency: The importance of early treatment.
Topics: Brain; Early Medical Intervention; Epilepsy; Humans; Infant, Newborn; Oxidoreductases; Pyridoxaminep | 2017 |
Pyridoxine-dependent epilepsies: an observational study on clinical, diagnostic, therapeutic and prognostic features in a pediatric cohort.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Cohort Studies; Epilepsy; Female; Humans; Infa | 2018 |
Pyridoxine for the treatment of isoniazid-induced seizures in intentional ingestions: The experience of a national poison center.
Topics: Administration, Intravenous; Adolescent; Adult; Aged; Antitubercular Agents; Female; Humans; Isoniaz | 2018 |
High-Fidelity Simulation Scenario: Pyridoxine-Dependent Epilepsy and Treatment.
Topics: Clinical Competence; Emergency Medicine; Epilepsy; High Fidelity Simulation Training; Humans; Infant | 2018 |
Findings of amplitude-integrated electroencephalogram recordings and serum vitamin B6 metabolites in perinatal lethal hypophosphatasia during enzyme replacement therapy.
Topics: Alkaline Phosphatase; Electroencephalography; Enzyme Replacement Therapy; Female; Humans; Hypophosph | 2019 |
Acute isoniazid intoxication: an uncommon cause of convulsion, coma and acidosis.
Topics: Acidosis; Antitubercular Agents; Coma; Humans; Infusions, Intravenous; Isoniazid; Male; Pyridoxine; | 2013 |
Infantile hypophosphatasia without bone deformities presenting with severe pyridoxine-resistant seizures.
Topics: Alkaline Phosphatase; Drug Resistance; Epilepsy; Humans; Hypophosphatasia; Infant; Male; Pyridoxal P | 2014 |
Pyridoxine or pyridoxal-5'-phosphate for neonatal epilepsy: the distinction just got murkier.
Topics: Animals; Brain Diseases, Metabolic; DNA Mutational Analysis; Female; Humans; Hypoxia-Ischemia, Brain | 2014 |
Pyridoxine responsiveness in novel mutations of the PNPO gene.
Topics: Aldehyde Dehydrogenase; Alleles; Animals; Brain Diseases, Metabolic; CHO Cells; Chromosome Deletion; | 2014 |
Seizure recurrence following pyridoxine withdrawal in a patient with pyridoxine-dependent epilepsy.
Topics: Aldehyde Dehydrogenase; Anticonvulsants; Brain; Diagnosis, Differential; DNA Mutational Analysis; El | 2015 |
Pyridoxine responsiveness in novel mutations of the PNPO gene.
Topics: Animals; Brain Diseases, Metabolic; DNA Mutational Analysis; Female; Humans; Hypoxia-Ischemia, Brain | 2015 |
Isoniazid induced convulsions at therapeutic dose in an alcoholic and smoker patient.
Topics: Adult; Alcoholism; Anticonvulsants; Antitubercular Agents; Humans; Isoniazid; Male; Pyridoxine; Risk | 2015 |
First cases of pyridoxine-dependent epilepsy in Bulgaria: novel mutation in the ALDH7A1 gene.
Topics: Aldehyde Dehydrogenase; Anticonvulsants; Bulgaria; Child; Child, Preschool; Dietary Supplements; DNA | 2015 |
Pyridoxine deficiency in adult patients with status epilepticus.
Topics: Adult; Child; Electroencephalography; Female; gamma-Aminobutyric Acid; Humans; Pyridoxine; Seizures; | 2015 |
Pyridoxine-Responsive Seizures in Infantile Hypophosphatasia and a Novel Homozygous Mutation in ALPL Gene.
Topics: Alkaline Phosphatase; Calcitonin; Diuretics; Female; Furosemide; Homozygote; Humans; Hypophosphatasi | 2016 |
[Clinical and genetic characteristics and detection of urinary pipecolic acid in pyridoxine dependent epilepsy].
Topics: Aldehyde Dehydrogenase; Asian People; Child; Child, Preschool; Delayed Diagnosis; DNA Mutational Ana | 2016 |
Phenotype, biochemical features, genotype and treatment outcome of pyridoxine-dependent epilepsy.
Topics: 2-Aminoadipic Acid; Adolescent; Aldehyde Dehydrogenase; Arginine; Child; Child, Preschool; Cohort St | 2017 |
Mutations in the ALDH7A1 gene cause pyridoxine-dependent seizures.
Topics: Aldehyde Dehydrogenase; Humans; Mutation; Pyridoxine; Seizures; Vitamin B 6 Deficiency | 2008 |
Two novel ALDH7A1 (antiquitin) splicing mutations associated with pyridoxine-dependent seizures.
Topics: Aldehyde Dehydrogenase; Child; DNA Mutational Analysis; Humans; Male; Mutation; Pharmacogenetics; Py | 2009 |
Clinical features and the management of pyridoxine-dependent and pyridoxine-responsive seizures: review of 63 North American cases submitted to a patient registry.
Topics: Canada; Humans; Metabolism, Inborn Errors; Pyridoxine; Rare Diseases; Registries; Seizures; United S | 2009 |
Pyridoxine-dependent seizures caused by alpha amino adipic semialdehyde dehydrogenase deficiency: the first polish case with confirmed biochemical and molecular pathology.
Topics: 2-Aminoadipic Acid; Aldehyde Dehydrogenase; Female; Humans; Poland; Pyridoxine; Seizures; Vitamin B | 2008 |
Prevalence of ALDH7A1 mutations in 18 North American pyridoxine-dependent seizure (PDS) patients.
Topics: Adolescent; Adult; Age of Onset; Aldehyde Dehydrogenase; Child; Child, Preschool; Cohort Studies; DN | 2009 |
Folinic acid-responsive seizures are identical to pyridoxine-dependent epilepsy.
Topics: Aldehyde Dehydrogenase; Biogenic Monoamines; DNA Mutational Analysis; Humans; Infant; Leucovorin; Li | 2009 |
Neonatal seizures: treatment and treatment variability in 31 United States pediatric hospitals.
Topics: Analysis of Variance; Anticonvulsants; Female; Humans; Infant, Newborn; Intensive Care, Neonatal; Lo | 2009 |
Very-late-onset pyridoxine-dependent seizures not linking to the known 5q31 locus.
Topics: Age of Onset; Anticonvulsants; Child; Chromosome Mapping; Chromosomes, Human, Pair 5; Electroencepha | 2008 |
Behavioral effects of levetiracetam mitigated by pyridoxine.
Topics: Anticonvulsants; Behavioral Symptoms; Child; Drug Therapy, Combination; Humans; Levetiracetam; Male; | 2009 |
Antenatal treatment in two Dutch families with pyridoxine-dependent seizures.
Topics: Child, Preschool; Female; Fetal Diseases; Fetus; Humans; Infant; Infant, Newborn; Magnetic Resonance | 2010 |
[Prolonged electrocerebral depression after oral administration of pyridoxine for pyridoxine-dependent convulsions].
Topics: Administration, Oral; Aldehyde Dehydrogenase; Anticonvulsants; Brain Death; Chromosome Aberrations; | 2010 |
Seizures and paroxysmal events: symptoms pointing to the diagnosis of pyridoxine-dependent epilepsy and pyridoxine phosphate oxidase deficiency.
Topics: Aldehyde Dehydrogenase; Anticonvulsants; Brain; Brain Diseases, Metabolic; Diagnosis, Differential; | 2010 |
Pyridoxine-dependent epilepsy and pyridoxine phosphate oxidase deficiency: unique clinical symptoms and non-specific EEG characteristics.
Topics: Anticonvulsants; Brain; Brain Diseases, Metabolic; Electroencephalography; Epilepsy; Eye Movements; | 2010 |
Beneficial interaction between clobenpropit and pyridoxine in prevention of electroshock-induced seizures in mice: lack of histaminergic mechanisms.
Topics: Animals; Anticonvulsants; Brain; Drug Interactions; Electroshock; Female; Histamine; Histamine H3 An | 2011 |
Toxin-related seizures.
Topics: Adenosine; Adult; Algorithms; Anticonvulsants; Child; Critical Pathways; Emergency Service, Hospital | 2011 |
Vitamin B6 deficiency: a potential cause of refractory seizures in adults.
Topics: Aged; Drug Resistance; Humans; Male; Middle Aged; Pyridoxal Phosphate; Pyridoxine; Seizures; Vitamin | 2011 |
Pyridoxine-dependent epilepsy: an under-recognised cause of intractable seizures.
Topics: Anticonvulsants; Child; Epilepsy; Humans; Male; Pyridoxine; Seizures; Treatment Outcome | 2012 |
Hypophosphatasia presenting with pyridoxine-responsive seizures, hypercalcemia, and pseudotumor cerebri: case report.
Topics: Alkaline Phosphatase; Consanguinity; Diagnosis, Differential; Fatal Outcome; Homozygote; Humans; Hyp | 2012 |
Effectiveness of B vitamins on the control of hypertension and stroke events of SHRSP rats.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Antioxidants; Ataxia; Blood Pressure; Dietar | 2010 |
Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5'-phosphate, GABA and anti-epileptic drugs.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbon; Folic Acid; gamma-Aminobutyric Acid; Larva; Mode | 2012 |
Pyridoxine-dependent seizures: long-term follow-up of two cases with clinical and MRI findings, and pyridoxine treatment.
Topics: Child; Consanguinity; Electroencephalography; Female; Follow-Up Studies; Humans; Infant, Newborn; Ma | 2002 |
Convulsions in young infants as a result of pyridoxine (vitamin B6) deficiency.
Topics: Child; Humans; Infant; Pyridoxine; Seizures; Vitamin B 6; Vitamin B 6 Deficiency | 1954 |
Convulsive seizures in infants with pyridoxine-deficient diet.
Topics: Diet; Humans; Infant; Pyridoxine; Seizures; Vitamin B 6 Deficiency | 1954 |
Pyridoxine dependency: report of a case of intractable convulsions in an infant controlled by pyridoxine.
Topics: Child; Epilepsy; Humans; Infant; Pyridoxine; Seizures; Vitamin B 6 | 1954 |
Experimental seizures in man and animals with acute pyridoxine deficiency produced by hydrazides.
Topics: Animals; Electroencephalography; Epilepsy; Humans; Male; Pyridoxine; Seizures; Vitamin B 6 Deficienc | 1956 |
Intake of vitamin B6 and infantile convulsions: a first approximation of requirements of pyridoxine in infants.
Topics: Child; Humans; Infant; Infant Nutritional Physiological Phenomena; Pyridoxine; Seizures; Vitamin B 6 | 1957 |
[Influence of pyridoxine and pyridoxal-5-phosphate on thiosemicarbazide cramps in rats].
Topics: Animals; Coenzymes; Muscle Cramp; Phosphates; Pyridoxal Phosphate; Pyridoxine; Rats; Seizures; Semic | 1957 |
[Pyridoxine-sensitive convulsions in newborn and other infants].
Topics: Avitaminosis; Child; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Pyridoxine; Seizure | 1959 |
[Convulsions in the neonatal period modified by pyridoxine].
Topics: Child; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Pyridoxine; Seizures; Vitamin B 6 | 1961 |
["Pyridoxine-dependent convulsions". Ist report in Italian literature].
Topics: Child; Epilepsy; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Pyridoxine; Seizures; V | 1961 |
The effects of pyridoxine antagonists and other convulsive agents on amino acid concentrations of the mouse brain.
Topics: Amino Acids; Animals; Brain; Brain Chemistry; Mice; Pyridoxine; Seizures; Vitamin B 6 | 1961 |
[Convulsions in the infant after insufficient supply or defective metabolic utilization of pyridoxine].
Topics: Biochemical Phenomena; Child; Humans; Infant; Pyridoxine; Seizures; Vitamin B 6 Deficiency | 1959 |
TROUBLE with pyridoxine.
Topics: Child; Humans; Infant; Pyridoxine; Seizures; Vitamin B 6 Deficiency | 1959 |
[Pyridoxin-dependent convulsions in infants. Metabolic-genetic epilepsy].
Topics: Child; Epilepsy; Genetics, Medical; Humans; Infant; Pyridoxine; Seizures; Vitamin B 6 | 1962 |
Pyridoxine-dependent convulsions in an infant.
Topics: Child; Epilepsy; Humans; Infant; Pyridoxine; Seizures; Vitamin B 6 Deficiency | 1962 |
[A case of convulsions and other neurological disorders caused by deficiency of pyridoxine in an alcoholic].
Topics: Alcoholism; Humans; Nervous System Diseases; Pyridoxine; Seizures; Vitamin B 6 Deficiency | 1962 |
Studies on fat-soluble vitamin B6. I. Atoxopyrimidine activity of pyridoxine palmitates.
Topics: Palmitates; Pyridoxine; Seizures; Vitamin B 6; Vitamins | 1961 |
SIGNS OF PYRIDOXINE DEPENDENCY MANIFEST AT BIRTH IN SIBLINGS.
Topics: Epilepsy; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Parturition; Physical | 1963 |
ACUTE POISONING FROM OVERDOSE OF ISONIAZID; A CASE REPORT.
Topics: Black People; Drug Overdose; Humans; Infant; Isoniazid; Pyridoxine; Seizures; Toxicology | 1963 |
[PYRIDOXINE-SENSITIVE CONVULSIVE SEIZURES. PRESENTATION OF A CASE].
Topics: Humans; Infant; Pyridoxine; Seizures; Vitamin B 6 Deficiency | 1963 |
METHOXYPYRIDOXINE CONVULSIONS IN EPILEPTIC AND NON-EPILEPTIC MICE. PROTECTIVE ACTION OF PYRIDOXINE.
Topics: Animals; Anticonvulsants; Antimetabolites; Epilepsy; Mice; Pharmacology; Pyridoxine; Research; Seizu | 1963 |
PRIDOXINE DEFICIENCY AND PYRIDOXINE DEPENDENCY IN INFANTS AND CHILDREN.
Topics: Biochemical Phenomena; Biochemistry; Child; Epilepsy; Female; Genetics, Medical; Humans; Infant; Inf | 1964 |
[CLINICAL OBSERVATIONS ON THE PROBLEM OF VITAMIN B 6 METABOLISM].
Topics: Body Fluids; Electroencephalography; Encephalitis; Epilepsy; Humans; Intellectual Disability; Pyrido | 1964 |
[EPILEPTIC SYNDROMES WITHIN THE FRAMEWORK OF CHRONIC HEADACHE].
Topics: Anticonvulsants; Diencephalon; Endocrinology; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; | 1964 |
POISONING OF THE RAT BY HYDRAZINE AND ALKYLHYDRAZINES.
Topics: Antidotes; Blood Glucose; Hydrazines; Pharmacology; Pyridoxal Phosphate; Pyridoxine; Rats; Research; | 1964 |
STUDIES ON THE MECHANISM OF ACTION OF AMINOOXYACETIC ACID. I. REVERSAL OF AMINOOXYACETIC ACID-INDUCED CONVULSIONS BY VARIOUS AGENTS.
Topics: Acetates; Acetone; Aldehydes; Aminooxyacetic Acid; Antidotes; Cats; Electroencephalography; Glycine; | 1964 |
PYRIDOXINE AND INFANTILE MYOCLONIC SEIZURES.
Topics: Amino Acids; Drug Therapy; Electroencephalography; Epilepsies, Myoclonic; Humans; Infant; Kynurenic | 1965 |
THE EFFECT OF PERIODIC CONVULSIONS INDUCED BY 1,1-DIMETHYLHYDRAZINE ON THE GLYCOGEN OF RAT BRAIN.
Topics: Brain; Brain Chemistry; Dimethylhydrazines; Glycogen; Hydrazines; Pharmacology; Phenobarbital; Phosp | 1965 |
ISONIAZID-INDUCED ENCEPHALOPATHY.
Topics: Brain Diseases; Drug Therapy; Epilepsy; Epilepsy, Tonic-Clonic; Isoniazid; Peripheral Nervous System | 1965 |
[Convulsions responsive to the administration of pyridoxine in a child three-and-one-half years of age. Preliminary note].
Topics: Pyridoxine; Seizures; Vitamin B 6 | 1960 |
Effects of pyridoxine, gamma-aminobutyric acid and gamma-amino-beta-hydroxybutyric acid on the convulsions of dogs caused by toxopyrimidine or isonicotinic acid hydrazide.
Topics: Amino Acids; Animals; Antifibrinolytic Agents; Dogs; gamma-Aminobutyric Acid; Isoniazid; Pyridoxine; | 1962 |
[Pyridoxine-dependence, a metabolic disease manifested by pyridoxine-sensitive convulsive seizures. (First familial case)].
Topics: Child; Epilepsy; Humans; Infant; Metabolic Diseases; Pyridoxine; Seizures; Vitamin B 6 Deficiency | 1961 |
Influence of large doses of pyridoxine hydrochloride on the convulsigenic activity of UDMH in monkeys.
Topics: Animals; Haplorhini; Hydrazines; Leadership; Pyridoxine; Seizures; Vitamin B 6 | 1961 |
[Pyridoxine-dependent seizures].
Topics: Child; Corpus Callosum; Female; Humans; Metabolism, Inborn Errors; Pyridoxine; Radiography; Seizures | 2004 |
Pyridoxine-dependent seizures and microcephaly.
Topics: Humans; Infant; Male; Microcephaly; Pyridoxine; Seizures | 2004 |
Pyridoxine dependent and pyridoxine responsive seizures.
Topics: Humans; Infant; Male; Pyridoxine; Seizures; Vitamin B 6 Deficiency; Vitamin B Complex | 2005 |
Pyridoxine or pyridoxal phosphate for intractable seizures?
Topics: Anticonvulsants; Child; Drug Resistance; Humans; Pyridoxal Phosphate; Pyridoxine; Seizures; Treatmen | 2005 |
Pyridoxal phosphate is better than pyridoxine for controlling idiopathic intractable epilepsy.
Topics: Administration, Oral; Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Administration Sche | 2005 |
Effect of isoniazid on the pharmacodynamics of cefazolin-induced seizures in rats.
Topics: Animals; Anti-Bacterial Agents; Brain; Cefazolin; Drug Synergism; Isoniazid; Male; Pyridoxine; Rats; | 2005 |
Persisting dementia after isoniazid overdose.
Topics: Adult; Antitubercular Agents; Dementia; Drug Overdose; Humans; Isoniazid; Male; Neurologic Examinati | 2005 |
Pyridoxine-dependent seizures and microcephaly.
Topics: Genetic Linkage; Humans; Microcephaly; Pyridoxine; Seizures | 2005 |
Genetic heterogeneity for autosomal recessive pyridoxine-dependent seizures.
Topics: Chromosome Disorders; Chromosome Mapping; Chromosomes, Human, Pair 5; Female; Genes, Recessive; Gene | 2005 |
Seizures, metabolic acidosis and coma resulting from acute isoniazid intoxication.
Topics: Acidosis; Acute Disease; Adolescent; Anticonvulsants; Antitubercular Agents; Charcoal; Child; Coma; | 2005 |
Hospital pharmacy and emergency department availability of parenteral pyridoxine.
Topics: Emergency Service, Hospital; Female; Health Care Surveys; Hospital Bed Capacity; Hospitals, General; | 2005 |
Prevalence of pyridoxine dependent seizures in south Indian children with early onset intractable epilepsy: A hospital based prospective study.
Topics: Adolescent; Age of Onset; Anticonvulsants; Child; Child, Preschool; Drug Resistance; Electroencephal | 2005 |
Mutations in antiquitin in individuals with pyridoxine-dependent seizures.
Topics: Aldehyde Dehydrogenase; Animals; Bacterial Proteins; Child; Child, Preschool; CHO Cells; Cricetinae; | 2006 |
Pyridoxine does not prevent hyperbaric oxygen-induced seizures in rats.
Topics: Animals; Hyperbaric Oxygenation; Injections, Intraperitoneal; Male; Premedication; Pyridoxine; Rando | 2006 |
Pyridoxine-dependent seizures in Dutch patients: diagnosis by elevated urinary alpha-aminoadipic semialdehyde levels.
Topics: Aldehyde Dehydrogenase; Biomarkers; Female; Humans; Hyperlysinemias; Netherlands; Pipecolic Acids; P | 2007 |
[Isoniazid intoxication].
Topics: Acidosis; Anticonvulsants; Antidotes; Antitubercular Agents; Diazepam; Female; Humans; Infusions, In | 2007 |
Pyridoxine-responsive seizures as the first symptom of infantile hypophosphatasia caused by two novel missense mutations (c.677T>C, p.M226T; c.1112C>T, p.T371I) of the tissue-nonspecific alkaline phosphatase gene.
Topics: Alkaline Phosphatase; Ethanolamines; Exons; Fatal Outcome; Female; Humans; Hypercalcemia; Hypercalci | 2007 |
Allelic and non-allelic heterogeneities in pyridoxine dependent seizures revealed by ALDH7A1 mutational analysis.
Topics: Aldehyde Dehydrogenase; DNA Mutational Analysis; Genes, Recessive; Glutamic Acid; Humans; Infant, Ne | 2007 |
Production and reversal of sensitivity to sound-induced convulsions associated with a pyridoxin deficiency.
Topics: Humans; Pyridoxine; Seizures; Sound; Vitamin B 6 Deficiency; Vitamin B Complex; Vitamins | 1949 |
Effect of magnesium chloride and magnesium L-aspartate on seizure threshold in rats under conditions of dietary magnesium deficiency.
Topics: Animals; Anticonvulsants; Aspartic Acid; Magnesium Chloride; Magnesium Deficiency; Male; Pentylenete | 2007 |
PNPO deficiency: an under diagnosed inborn error of pyridoxine metabolism.
Topics: Amino Acid Substitution; Animals; Brain Diseases, Metabolic, Inborn; CHO Cells; Codon, Nonsense; Con | 2008 |
Familial intrauterine convulsions in pyridoxine dependency.
Topics: Adult; Aspartate Aminotransferases; Electroencephalography; Erythrocytes; Female; Fetal Diseases; Hu | 1967 |
Metabolism of beta-cyanoalanine.
Topics: Alanine; Aldehydes; Amino Acids; Animals; Body Weight; Brain Chemistry; Chromatography, Ion Exchange | 1967 |
[Acute isoniazid poisoning in a young child (author's transl)].
Topics: Humans; IgA Vasculitis; Infant; Isoniazid; Male; Pyridoxine; Renal Dialysis; Seizures | 1981 |
Alterations in the content of amino acid neurotransmitters before the onset and during the course of methoxypyridoxine-induced seizures in individual rabbit brain regions.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glut | 1983 |
GABA in brain tissue of paroxysmal (px) chick.
Topics: Animals; Brain Chemistry; Chickens; gamma-Aminobutyric Acid; Genes, Recessive; Male; Pyridoxine; Sei | 1984 |
Homocysteine induced convulsions: enhancement by vitamin B6 and inhibition by hydrazine.
Topics: Animals; Female; Homocysteine; Hydrazines; Mice; Neural Inhibition; Pyridoxine; Seizures; Synaptic T | 1981 |
Competitive inhibition between 4'-substituted pyridoxine analogues and pyridoxal for pyridoxal kinase from mouse brain.
Topics: Animals; Binding, Competitive; Brain; Kinetics; Mice; Phosphotransferases; Pyridoxal; Pyridoxal Kina | 1980 |
Amino acid metabolism in the brain with convulsive disorders. Part 2: The effects of anticonvulsants on convulsions and free amino acid patterns in the brain of El mouse.
Topics: Adrenocorticotropic Hormone; Amino Acids; Animals; Anticonvulsants; Brain; Mice; Mice, Inbred Strain | 1984 |
Pyridoxine dependent seizures.
Topics: Humans; Infant; Infant, Newborn; Pyridoxine; Seizures | 1984 |
Alteration of convulsive threshold and conditioned avoidance response in mice fed diets containing contraceptive steroids.
Topics: Animals; Avoidance Learning; Contraceptives, Oral; Contraceptives, Oral, Hormonal; Diet; Female; Mes | 1984 |
Isoniazid overdose treated with high-dose pyridoxine.
Topics: Acidosis; Adolescent; Adult; Female; Humans; Isoniazid; Male; Pyridoxine; Seizures | 1983 |
Late-onset pyridoxine-dependency convulsions.
Topics: Child; Humans; Male; Pyridoxine; Seizures | 1983 |
Vitamin B6 intake and plasma pyridoxal phosphate concentrations in the first 2 weeks of life.
Topics: Bilirubin; Female; Humans; Infant Food; Infant Nutritional Physiological Phenomena; Infant, Newborn; | 1984 |
Vitamin-mineral supplement fails to improve IQ of mentally retarded young adults.
Topics: Adolescent; Adult; Double-Blind Method; Edema; Evoked Potentials; Female; Humans; Intellectual Disab | 1984 |
Stability, bactericidal activity, vitamin B6 activity and gastrointestinal absorption of benzoic acid esters of pyridoxine.
Topics: Absorption; Animals; Anti-Bacterial Agents; Bacillus subtilis; Benzoates; Benzoic Acid; Digestive Sy | 1981 |
Pyridoxine-dependent seizures.
Topics: Electroencephalography; gamma-Aminobutyric Acid; Humans; Infant; Infant, Newborn; Infant, Newborn, D | 1983 |
Pyridoxine-dependency seizure: report of a rare presentation.
Topics: Humans; Infant; Male; Pyridoxine; Seizures | 1983 |
Pyridoxine dependent seizures--a wider clinical spectrum.
Topics: Epilepsy; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Male; Pyridoxine; Seiz | 1983 |
Acute isoniazid poisoning in childhood.
Topics: Adolescent; Child, Preschool; Coma; Female; Humans; Infant; Isoniazid; Male; Paraldehyde; Pyridoxine | 1980 |
Acute effects of pyridoxine hydrochloride on monomethylhydrazine seizure latency and amygdaloid kindled seizure thresholds in cats.
Topics: Amygdala; Animals; Cats; Kindling, Neurologic; Methylhydrazines; Monomethylhydrazine; Pyridoxine; Se | 1982 |
Therapeutics of monomethylhydrazine intoxication.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Therapy, Combination; Male; Methylhydrazin | 1982 |
Increase in taurine content before onset of seizures induced by a glutamate decarboxylase inhibitor.
Topics: Animals; Brain; Carboxy-Lyases; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Male; Pyridoxine; | 1982 |
A possible neurochemical basis of the central stimulatory effects of pp'DDT.
Topics: Acetylcholine; Aminooxyacetic Acid; Ammonia; Animals; Central Nervous System; Corpus Striatum; DDT; | 1981 |
Selected ion monitoring determination of acetylcholine during methoxypyridoxine seizures.
Topics: Acetylcholine; Animals; Brain Chemistry; Mass Spectrometry; Pyridoxine; Rabbits; Seizures | 1980 |
Single high-dose pyridoxine treatment for isoniazid overdose.
Topics: Acidosis; Adolescent; Adult; Bicarbonates; Coma; Female; Humans; Isoniazid; Male; Pyridoxine; Seizur | 1981 |
Effects of variations in glutamic acid decarboxylase activity on acute oxygen poisoning.
Topics: Animals; Brain; Carboxy-Lyases; Glutamate Decarboxylase; Glycogen; Hyperbaric Oxygenation; Kinetics; | 1981 |
Isoniazid toxicity. Pyridoxine controlled seizures in a dialysis patient.
Topics: Female; Humans; Isoniazid; Middle Aged; Pyridoxine; Renal Dialysis; Seizures; Tuberculosis, Pulmonar | 1981 |
Large dense-core vesicle exocytosis and membrane recycling in the mossy fibre synapses of the rabbit hippocampus during epileptiform seizures.
Topics: Animals; Exocytosis; Freeze Fracturing; Hippocampus; Pyridoxine; Rabbits; Seizures; Synapses; Synapt | 1981 |
Acute isoniazid poisoning in children.
Topics: Acute Disease; Child, Preschool; Coma; Diazepam; Female; Humans; Isoniazid; Pyridoxine; Seizures | 1981 |
Delay of nomifensine induced convulsions by pyridoxine HCl.
Topics: Animals; Isoquinolines; Male; Nomifensine; Pyridoxine; Rats; Seizures; Time Factors | 1980 |
Vitamin B6 deficiency and dependency.
Topics: Female; Humans; Infant; Infant, Newborn; Pregnancy; Pyridoxine; Seizures; Vitamin B 6 Deficiency | 1980 |
[Pyridoxine-dependent epilepsy in an infant].
Topics: Anticonvulsants; Female; Genes, Recessive; Humans; Infant, Newborn; Pyridoxine; Seizures | 1995 |
Isoniazid-associated rhabdomyolysis.
Topics: Adolescent; Charcoal; Chemical and Drug Induced Liver Injury; Diazepam; Female; Humans; Isoniazid; P | 1995 |
Acute isoniazid neurotoxicity in an urban hospital.
Topics: Acute Disease; Adolescent; Child; Female; Humans; Infant, Newborn; Infusions, Intravenous; Isoniazid | 1995 |
Pyridoxine dependent epilepsy with iatrogenic sensory neuronopathy.
Topics: Action Potentials; Adolescent; Electrophysiology; Epilepsy; Ganglia, Spinal; Humans; Iatrogenic Dise | 1995 |
INH-induced neurotoxicity.
Topics: Acidosis; Adult; Brain; Drug Overdose; Humans; Isoniazid; Pyridoxine; Seizures | 1994 |
Pyridoxine-dependent seizures associated with white matter abnormalities.
Topics: Brain; Child, Preschool; Demyelinating Diseases; gamma-Aminobutyric Acid; Humans; Male; Nerve Tissue | 1994 |
Picrotoxin and pentylene tetrazole induced seizure activity in pyridoxine-deficient rats.
Topics: Animals; Cerebral Cortex; Differential Threshold; Electroencephalography; Electronic Data Processing | 1994 |
Reduced GABA synthesis in pyridoxine-dependent seizures.
Topics: Administration, Oral; Electroencephalography; Female; Fibroblasts; gamma-Aminobutyric Acid; Genetic | 1994 |
Aminooxyacetic acid produces excitotoxic brain injury in neonatal rats.
Topics: Aminooxyacetic Acid; Animals; Animals, Newborn; Anti-Anxiety Agents; Benzodiazepines; Brain; Corpus | 1993 |
[Pyridoxine for severe metabolic acidosis and seizures due to isoniazid overdose].
Topics: Acidosis; Adolescent; Drug Overdose; Female; Humans; Infusions, Intravenous; Isoniazid; Pyridoxine; | 1993 |
Audiogenic seizures in magnesium-deficient mice: effects of magnesium pyrrolidone-2-carboxylate, magnesium acetyltaurinate, magnesium chloride and vitamin B-6.
Topics: Acoustic Stimulation; Animals; Diet; Injections, Intravenous; Magnesium; Magnesium Chloride; Magnesi | 1993 |
[Studies on the constituents of edible and medicinal plants. IV. Determination of 4-O-methylpyridoxine in serum of the patient with gin-nan food poisoning].
Topics: Chromatography, High Pressure Liquid; Humans; Infant; Plant Poisoning; Plants, Edible; Pyridoxine; S | 1993 |
Reversible seizures and mental status changes in a dialysis patient on isoniazid preventive therapy.
Topics: Aged; Confusion; Female; Humans; Isoniazid; Peritoneal Dialysis, Continuous Ambulatory; Pyridoxine; | 1993 |
Pyridoxine as therapy in theophylline-induced seizures.
Topics: Aminophylline; Animals; Bronchodilator Agents; Disease Models, Animal; Electroencephalography; Femal | 1995 |
Pyridoxine dependent seizures.
Topics: Child, Preschool; Developing Countries; Female; Humans; India; Infant; Infant, Newborn; Injections, | 1996 |
Pyridoxine-dependent seizures: demographic, clinical, MRI and psychometric features, and effect of dose on intelligence quotient.
Topics: Adolescent; Age of Onset; Child; Cross-Sectional Studies; Humans; Intelligence; Magnetic Resonance I | 1996 |
Bilobalide, a constituent of Ginkgo biloba L., potentiates drug-metabolizing enzyme activities in mice: possible mechanism for anticonvulsant activity against 4-O-methylpyridoxine-induced convulsions.
Topics: Administration, Oral; Animals; Anticonvulsants; Cyclopentanes; Diterpenes; Dose-Response Relationshi | 1997 |
Proconvulsant effects induced by pyridoxine in young rats.
Topics: Aging; Animals; Brain; Convulsants; Electroencephalography; Epilepsy; Female; Male; Motor Activity; | 1998 |
Seizures induced by theophylline and isoniazid in mice.
Topics: Animals; Antitubercular Agents; Bronchodilator Agents; Dose-Response Relationship, Drug; Female; Iso | 1999 |
Demographics and diagnosis of pyridoxine-dependent seizures.
Topics: Anticonvulsants; Humans; Incidence; Infant, Newborn; Phenobarbital; Pyridoxine; Seizures; United Kin | 1999 |
Neonatal seizures after use of pyridoxine in pregnancy.
Topics: Adult; Female; Humans; Infant, Newborn; Pregnancy; Pyridoxine; Seizures; Self Medication; Substance | 1999 |
Pyridoxine treatment for seizures induced by theophylline and isoniazid?
Topics: Animals; Drug Interactions; Isoniazid; Mice; Pyridoxine; Seizures; Theophylline | 1999 |
Epidemiology of pyridoxine dependent and pyridoxine responsive seizures in the UK.
Topics: Adolescent; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Hypoxia-Ischemia, Brain; Inc | 1999 |
Age-specific N-methyl-D-aspartate-induced seizures: perspectives for the West syndrome model.
Topics: Age Factors; Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Humans; Hydr | 1999 |
Pyridoxine dependent epilepsy: a suggestive electroclinical pattern.
Topics: Electroencephalography; Humans; Pyridoxine; Seizures | 2000 |
Pyridoxal phosphate de-activation by pyrroline-5-carboxylic acid. Increased risk of vitamin B6 deficiency and seizures in hyperprolinemia type II.
Topics: Aldehydes; Avitaminosis; Chromatography, High Pressure Liquid; Humans; Ketones; Magnetic Resonance S | 2001 |
CSF glutamate/GABA concentrations in pyridoxine-dependent seizures: etiology of pyridoxine-dependent seizures and the mechanisms of pyridoxine action in seizure control.
Topics: gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Humans; Infant; Male; Pyridoxine; S | 2001 |
Gas chromatography-mass spectrometry analysis of 4-O-methylpyridoxine (MPN) in the serum of patients with ginkgo seed poisoning.
Topics: Antidotes; Chromatography, Gas; Female; Gas Chromatography-Mass Spectrometry; Ginkgo biloba; Humans; | 2002 |
Pyridoxine-dependent seizures associated with hypophosphatasia in a newborn.
Topics: Bone Density; Bone Diseases; Consanguinity; Drug Administration Schedule; Electroencephalography; Fe | 2002 |
[Convulsive disorders in inborn errors of metabolism (author's transl)].
Topics: Electroencephalography; Gangliosidoses; Homocystinuria; Humans; Metabolism, Inborn Errors; Phenylket | 1979 |
Anticonvulsant effects of restraint and pyridoxine on hydrazine seizures in the monkey.
Topics: Animals; Brain; Electroencephalography; Female; Macaca mulatta; Methylhydrazines; Monomethylhydrazin | 1979 |
Vitamin B6 responsive infantile convulsions and branched chain amino aciduria.
Topics: Adult; Amino Acids, Branched-Chain; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male | 1978 |
Effects of alterations in the metabolism of gamma-aminobutyrate on convulsant potencies.
Topics: 3-Mercaptopropionic Acid; Aminobutyrates; Aminooxyacetic Acid; Animals; Bicuculline; Diacetyl; Drug | 1977 |
The B vitamins and vitamin C in human nutrition. I. General considerations and 'obligatory' B vitamins.
Topics: Amino Acids; Anemia, Hypochromic; Ascorbic Acid; Diet; Humans; Nutritional Physiological Phenomena; | 1979 |
On the mechanism of pyridoxal phosphate-related convulsions as implicated in enhanced transport of GABA.
Topics: Animals; Antimetabolites; Cerebral Cortex; gamma-Aminobutyric Acid; Male; Pyridoxal Kinase; Pyridoxa | 1979 |
Pyridoxine-dependent seizures requiring high doses of pyridoxine for control.
Topics: Electroencephalography; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Pyridoxine; Seizur | 1979 |
Alterations in seizure mechanisms caused by oxygen high pressure, 1,1-dimethylhydrazine, and pyridoxine.
Topics: Animals; Brain; Convulsants; Dimethylhydrazines; Glycogen; Hyperbaric Oxygenation; Male; Methylhydra | 1979 |
Effect of antivitamin B6 on regional GABA metabolism in mouse brain and its relation to convulsions.
Topics: 4-Aminobutyrate Transaminase; Aminooxyacetic Acid; Animals; Brain; gamma-Aminobutyric Acid; Glutamat | 1979 |
Running fit induced by injection of semicarbazide into the superior colliculus of the mouse.
Topics: Aminooxyacetic Acid; Animals; Brain; gamma-Aminobutyric Acid; Injections; Male; Mice; Pyridoxine; Ru | 1977 |
Relationship between gamma-aminobutyric acid metabolism and antivitamin B6-induced convulsions.
Topics: 4-Aminobutyrate Transaminase; Acetates; Aminooxyacetic Acid; Animals; Brain; gamma-Aminobutyric Acid | 1978 |
Evaluation of diazepam and pyridoxine as antidotes to isoniazid intoxication in rats and dogs.
Topics: Animals; Antidotes; Diazepam; Dogs; Drug Therapy, Combination; Isoniazid; Male; Pyridoxine; Rats; Se | 1978 |
Pyridoxol metabolism in vitamin B6-responsive convulsions of early infancy.
Topics: Adult; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Pyridoxine; Seizures | 1978 |
Infantile convulsion suspected of pyridoxine responsive seizures.
Topics: Brain; Humans; Infant; Infant, Newborn; Male; Pyridoxine; Seizures; Vitamin B 6 Deficiency | 1978 |
Reversal of the toxicity of hydrazine an analogues by pyridoxine hydrochloride.
Topics: Animals; Female; Hydrazines; Male; Mice; Pyridoxine; Seizures | 1977 |
gamma-Aminobutyric acid metabolism in subcellular particles of mouse brain and its relationship to convulsions.
Topics: 4-Aminobutyrate Transaminase; Aminobutyrates; Animals; Brain; gamma-Aminobutyric Acid; Glutamate Dec | 1977 |
Pyridoxine dependant convulsions (a case report).
Topics: Humans; Infant, Newborn; Male; Metabolism, Inborn Errors; Pyridoxine; Seizures | 1977 |
Convulsive seizure induced by intracerebral injection of semicarbazide (an anti-vitamin B6) in the mouse.
Topics: Animals; Antimetabolites; Dose-Response Relationship, Drug; Drug Synergism; Injections, Intraventric | 1976 |
Preconvulsive changes in brain glucose metabolism following drugs inhibiting glutamate decarboxylase.
Topics: Animals; Blood Glucose; Body Temperature; Brain; Carboxy-Lyases; Glucose; Glutamate Decarboxylase; G | 1976 |
Modification of pp' DDT induced convulsions by changes in the level of cerebral gamma-aminobutyric acid in mice.
Topics: Aminobutyrates; Aminooxyacetic Acid; Ammonia; Animals; Brain; DDT; gamma-Aminobutyric Acid; Hydroxyl | 1976 |
[Pyridoxine-dependent convulsion in the newborn].
Topics: Electroencephalography; Epilepsy, Temporal Lobe; Humans; Infant, Newborn; Pulmonary Artery; Pyridoxi | 1976 |
Antivitamin B6 induced ultrastructural changes in the hippocampus of the convulsant rabbit and its biochemical correlates.
Topics: Animals; Caudate Nucleus; Female; gamma-Aminobutyric Acid; Hippocampus; Hypothalamus; Male; Putamen; | 1976 |
Effect of succinic semialdehyde on seizure caused by vitamin B6 antagonists.
Topics: Aldehydes; Animals; gamma-Aminobutyric Acid; Hydroxybutyrates; Male; Mice; Penicillamine; Pyridoxine | 1976 |
Neonatal pyridoxine responsive convulsions due to isoniazid therapy.
Topics: Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Isoniazid; Male; Pregnancy; Preg | 1976 |
Treatment of acute isoniazid toxicity.
Topics: Acidosis; Adolescent; Adult; Airway Obstruction; Anticonvulsants; Bicarbonates; Coma; Diuresis; Fema | 1975 |
Levels of pyridoxine and susceptibility to electroconvulsive and audiogenic seizures.
Topics: Acoustic Stimulation; Animal Feed; Animals; Brain Chemistry; Electroshock; Genotype; Mice; Mice, Inb | 1975 |
Effects of single doses and daily administration of pyrithioxine (pyritinolum,NFN, RINN) on the alcohol withdrawal syndrome in rats.
Topics: Animals; Body Weight; Electrolytes; Ethanol; Humans; Male; Pyridoxine; Pyrithioxin; Rats; Seizures; | 1975 |
Differential decrease of GABA in the substantia nigra and other discrete regions of the rabbit brain during the preictal period of methoxypyridoxine-induced seizures.
Topics: Action Potentials; Aminobutyrates; Animals; Brain; Caudate Nucleus; Cerebellar Cortex; Frontal Lobe; | 1976 |
Isoniazid-induced convulsions.
Topics: Adolescent; Adult; Animals; Child, Preschool; Drug Combinations; Female; Humans; Isoniazid; Male; Py | 1976 |
The effect of castrix (2-chloro-4- dimethylamino-6-methylpyrimidine) on the distribution of B6 vitamers in mouse brain.
Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Isoniazid; Male; Mice; Penicillamine; Pyridoxa | 1976 |
[The effect of acupuncture on high oxygen pressure-induced convulsion and its relationship to the brain GABA concentration in mice].
Topics: Acupuncture Therapy; Animals; Brain; Female; gamma-Aminobutyric Acid; Hyperbaric Oxygenation; Male; | 1992 |
Disturbance of GABA metabolism in pyridoxine-dependent seizures.
Topics: Brain; Chromosomes, Human, Pair 2; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; Infant; | 1992 |
Pyridoxine-dependent seizures: report of a case with atypical clinical features and abnormal MRI scans.
Topics: Brain; Cerebral Ventricles; Child, Preschool; Electroencephalography; Female; Humans; Infant; Infant | 1992 |
Intravenous immunoglobulin and pyridoxine-dependent seizures.
Topics: Child, Preschool; Humans; Immunization, Passive; Male; Pyridoxine; Seizures; Status Epilepticus | 1991 |
[Chronological change of EEG findings in a case of pyridoxine dependency seizures].
Topics: Administration, Oral; Electroencephalography; Humans; Infant; Injections, Intravenous; Male; Monitor | 1990 |
Pyridoxine dependent seizures in a newborn.
Topics: Female; Humans; Infant, Newborn; Injections, Intramuscular; Pyridoxine; Recurrence; Seizures; Vitami | 1990 |
Isoniazid toxicity presenting as seizures and metabolic acidosis.
Topics: Acidosis; Adolescent; Humans; Infusions, Intravenous; Isoniazid; Male; Pyridoxine; Seizures | 1990 |
c-Fos mRNA induction under vitamin B6 antagonist-induced seizure.
Topics: Animals; Blotting, Northern; Brain; Hydrazines; Male; Mice; Mice, Inbred ICR; Penicillamine; Proto-O | 1989 |
Effects of carbon dioxide on onsets of seizures in mice induced by antagonists of vitamin B6.
Topics: Animals; Carbon Dioxide; Mice; Penicillamine; Pyridoxine; Seizures; Semicarbazides | 1987 |
Disappearance of neonatal seizures and low CSF GABA levels after treatment with vitamin B6.
Topics: gamma-Aminobutyric Acid; Humans; Infant; Infant, Newborn; Male; Pyridoxine; Seizures | 1987 |
Pathophysiological aspects of blood-brain barrier permeability in epileptic seizures.
Topics: Animals; Bicuculline; Blood Pressure; Blood-Brain Barrier; Cerebrovascular Circulation; Endothelium; | 1986 |
The natural history of homocystinuria due to cystathionine beta-synthase deficiency.
Topics: Adolescent; Adult; Child; Child, Preschool; Clinical Enzyme Tests; Cystathionine beta-Synthase; Fema | 1985 |
Pyridoxine deficiency in children treated with isoniazid.
Topics: Child; Child Nutritional Physiological Phenomena; Child, Preschool; Electromyography; Female; Humans | 1985 |
Photic and drug-induced epilepsy in the baboon (Papio papio): the effects of isoniazid, thiosemicarbazide, pyridoxine and amino-oxyacetic acid.
Topics: Acetates; Aminobutyrates; Animals; Behavior, Animal; Cerebral Cortex; Electroencephalography; Haplor | 1970 |
Development of an expression which relates the excitable state of the brain to the level of GAD activity and GABA content, with particular reference to the action of hydrazine and its derivatives.
Topics: Aminobutyrates; Animals; Brain; Carboxy-Lyases; Chickens; Dose-Response Relationship, Drug; Fasting; | 1974 |
The EEG in pyridoxine-dependent convulsions.
Topics: Cerebral Cortex; Child; Child, Preschool; Electroencephalography; Humans; Infant; Infant, Newborn; P | 1970 |
Seizures induced by allylglycine, 3-mercaptopropionic acid and 4-deoxypyridoxine in mice and photosensitive baboons, and different modes of inhibition of cerebral glutamic acid decarboxylase.
Topics: Allyl Compounds; Animals; Brain; Carboxy-Lyases; Electroencephalography; Glutamates; Glycine; Haplor | 1973 |
[Neuropsychiatric incidences in antitubercular treatment consisting of isoniazid or isoniazid and ethionamide (8 cases)].
Topics: Acidosis; Adult; Alcoholism; Ammonia; Avitaminosis; Carboxy-Lyases; Chromatography, Paper; Chromatog | 1969 |
Vitamin B 6 dependent convulsions manifest in a case of Down's syndrome.
Topics: Down Syndrome; Female; Humans; Infant, Newborn; Male; Metabolism, Inborn Errors; Pyridoxine; Seizure | 1972 |
Infantile spasms associated with 5-hydroxytryptophan administration in patients with Down's syndrome.
Topics: 5-Hydroxytryptophan; Adrenocorticotropic Hormone; Brain; Down Syndrome; Electroencephalography; Huma | 1971 |
Use of chronic irritative foci in laboratory evaluation of antiepileptic drugs.
Topics: Aluminum; Aminobutyrates; Animals; Bemegride; Central Nervous System Stimulants; Chlordiazepoxide; C | 1969 |
The influence of tyrosine, phenylpyruvate and vitamin B 6 upon seizure thresholds.
Topics: Amino Acids; Animals; Brain; Brain Chemistry; Central Nervous System Stimulants; Ethers; Fluorine; M | 1971 |
On the convulsive action of castrix.
Topics: Animals; Aspartate Aminotransferases; Carboxy-Lyases; Central Nervous System Stimulants; Cholinester | 1972 |
Susceptibility to thiosemicarbazide (an antagonist of vitamin B6), and phylogenetic and ontogenetic development of brain.
Topics: Age Factors; Animals; Animals, Newborn; Astacoidea; Behavior, Animal; Biological Evolution; Bombyx; | 1974 |
An examination of the role of gamma-aminobutyric acid (GABA) in hyperbaric oxygen-induced convulsions in the rat. II. Influence of metabolic cofactors.
Topics: Acetates; Aminobutyrates; Animals; Drug Synergism; Female; Hydrazines; Hyperbaric Oxygenation; Propi | 1974 |
[Vitamin B6-dependency syndrome].
Topics: Asphyxia Neonatorum; Chromosome Aberrations; Chromosome Disorders; Female; Humans; Infant, Newborn; | 1974 |
Neonatal transitory hypomagnesaemia.
Topics: Calcium; Diazepam; Electrocardiography; Electroencephalography; Humans; Infant; Magnesium; Magnesium | 1972 |
Further studies on the role of -aminobutyric acid in paraoxon-induced convulsions.
Topics: Acetylcholine; Aminobutyrates; Animals; Brain Chemistry; Drug Interactions; Hydroxylamines; Insectic | 1973 |
[Clinical and electroencephalographic characteristics of convulsive manifestations in the neonatal age].
Topics: Electroencephalography; Glucose; Humans; Hypertonic Solutions; Infant, Newborn; Infant, Newborn, Dis | 1973 |
The anticonvulsant properties of isonicotinic acid hydrazide and associated changes in gamma-aminobutyric acid metabolism.
Topics: Aminobutyrates; Animals; Anticonvulsants; Carbon Radioisotopes; Carboxy-Lyases; Chickens; Glutamates | 1973 |
Seizures in newborn infants.
Topics: Birth Injuries; Brain; Calcium; Diazepam; Gluconates; Glucose; Humans; Hypocalcemia; Hypoxia; Infant | 1974 |
Isoniazid toxicity. Reversal with pyridoxine.
Topics: Adolescent; Diazepam; Humans; Hyperglycemia; Hypothermia; Isoniazid; Lactates; Male; Pyridoxine; Sei | 1974 |
Fine structure of cat hippocampus during sustained seizure.
Topics: Animals; Cats; Hippocampus; Histological Techniques; Microscopy, Electron; Neuroglia; Neurons; Penic | 1970 |
Monosodium glutamate induces convulsive disorders in rats.
Topics: Animals; Diet; Electroencephalography; Glutamates; Male; Pyridoxine; Rats; Salivation; Seizures; Sod | 1971 |
[Tryptophan metabolism in pyridoxine-dependent convulsions].
Topics: Chemistry, Clinical; Child; Child, Preschool; Chromatography, Thin Layer; Epilepsy, Tonic-Clonic; Hu | 1971 |
Further observations on the role of -aminobutyric acid in insulin-induced hypoglycaemic convulsions.
Topics: Acetates; Amino Acids; Aminobutyrates; Animals; Anticonvulsants; Blood Glucose; Brain; Brain Chemist | 1972 |
Cuprizone toxicosis in mice--attempts to antidote the toxicity.
Topics: Aminobutyrates; Animals; Arginine; Body Weight; Cerebral Cortex; Chelating Agents; Cyclohexanes; Dru | 1972 |
The effect on GABA metabolism in brain of isonicotinic acid hydrazide and pyridoxine as a fuction of time after administration.
Topics: Aminobutyrates; Animals; Brain; Brain Chemistry; Carbon Isotopes; Carboxy-Lyases; Chickens; Enzyme A | 1972 |
[Familial pyridoxine deficiency in a diabetic patient and her children. Infantile myoclonic encephalopathy with hypsarrhythmia cured with vitamin B 6 in one of them].
Topics: Adult; Electroencephalography; Female; Humans; Infant; Infant, Newborn; Male; Pregnancy; Pregnancy i | 1972 |
[Clinical and biochemical studies in pyridoxine-dependent seizures].
Topics: Humans; Infant; Infant, Newborn; Pyridoxine; Quinolines; Seizures; Tryptophan; Vitamin B 6 Deficienc | 1972 |
The evaluation of the vitamin B 6 status in children with convulsions.
Topics: Child; Cystathionine; Humans; Infant; Pyridoxine; Saccharomyces; Seizures; Vitamin B 6 Deficiency | 1972 |
[Convulsions caused by vitamin B-6 dependence in the newborn infant. Review of the subject and report of 2 clinical cases].
Topics: Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Metabolism, Inborn Errors; Pregn | 1971 |
Pyridoxine dependent convulsion: effect of pyridoxine therapy on electroencephalograms.
Topics: Child; Electroencephalography; Humans; Injections, Intramuscular; Male; Pyridoxine; Seizures | 1971 |
[Pyridoxine responsive seizures in an infant (author's transl)].
Topics: Aspartate Aminotransferases; Erythrocytes; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; | 1971 |
Pre-ictal and ictal changes of serotonin, GABA and glutamate contents in different regions of rabbit brain during methoxypyridoxine-induced seizures.
Topics: Aminobutyrates; Animals; Basal Ganglia; Brain; Brain Chemistry; Brain Stem; Caudate Nucleus; Cerebel | 1971 |
Ectopia lentis due to homocystinuria.
Topics: Adolescent; Child; Diagnosis, Differential; Female; Hemorrhage; Homocystinuria; Humans; Lens, Crysta | 1971 |
The role of vitamin B6 in the toxicity of hydrazines.
Topics: Amino Acids; Animals; Brain Chemistry; Calcium; Hydrazines; Injections; Injections, Intraperitoneal; | 1969 |
Pyridoxine and myoclonic seizures.
Topics: Female; Humans; Infant; ortho-Aminobenzoates; Pyridoxine; Seizures; Spasm; Tryptophan; Xanthurenates | 1969 |
Pyridoxine in the prevention and treatment of convulsions and neurotoxicity due to cycloserine.
Topics: Cycloserine; Humans; Male; Middle Aged; Neurons; Pyridoxine; Seizures | 1969 |
Glutamic acid decarboxylase (GAD) in mammalian tissue outside the central nervous system, and its possible relevance to hereditary vitamin B6 dependency with seizures.
Topics: Aminobutyrates; Animals; Autopsy; Brain; Carbon Dioxide; Carbon Isotopes; Carboxy-Lyases; Female; Gl | 1969 |
Tissue monoamine oxidase inhibitions by convulsigenic doses of hydrazines and related B6-hydrazones. SAM-TR-66-79.
Topics: Animals; Brain; Hydrazines; Liver; Male; Monoamine Oxidase Inhibitors; Pyridoxine; Rats; Seizures | 1966 |
Observations on the effects of decaborane and several potential antidotes in the rat. SAM-TR-67-103.
Topics: Animals; Antidotes; Ataxia; Boron Compounds; Male; Methanol; Pargyline; Picolines; Pyridoxine; Rats; | 1967 |
[Vitamins and pregnancy].
Topics: Abortion, Spontaneous; Anemia, Hemolytic, Congenital; Animals; Ascorbic Acid; Ergocalciferols; Femal | 1967 |
Death following massive ingestion of isoniazid.
Topics: Acidosis; Adolescent; Anticonvulsants; Coma; Fever; Gastric Lavage; Humans; Intubation, Intratrachea | 1969 |
[Neurotoxic side-effects of piperazine derivatives in electroencephalography. 3. Animal experimental studies on rabbits].
Topics: Animals; Brain; Disease Models, Animal; Electroencephalography; Piperazines; Pyridoxine; Rabbits; Se | 1969 |
Secondary cystathioninuria.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Bronchopneumonia; Female; Humans; Infant; Infant, | 1969 |
[Seizures in newborn infants].
Topics: Birth Injuries; Cerebral Hemorrhage; Diazepam; Female; Glucose; Humans; Hypernatremia; Hypoglycemia; | 1969 |
The effect of penicillamine on seizure threshold. The role of pyridoxine.
Topics: Animals; Disease Models, Animal; Male; Myoclonus; Penicillamine; Pyridoxine; Rats; Seizures; Tryptop | 1970 |
Pyridoxine dependency and penicillamine.
Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Kidney Function Tests; Penicillamine; Ph | 1970 |
[Vitamin-B6-dependent pediatric diseases. Hereditary pyridoxine-dependent spasms in newborns and xanthurenuria in parents].
Topics: Adult; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Metabolism, Inborn Errors; Pregna | 1970 |
The relationships between phenylalanine, phenylpyruvate, vitamin B-6 and seizure threshold.
Topics: Drug Antagonism; Phenylalanine; Phenylpyruvic Acids; Pyridoxal Phosphate; Pyridoxine; Seizures; Time | 1970 |
[Influence of isoniazid (INH) on the central nervous system and the antagonism between isoniazid and pyridoxine as well as pantothenic acid and coumarin from Melilotus officinalis in rats].
Topics: Animals; Central Nervous System; Conditioning, Classical; Coumarins; Disease Models, Animal; Isoniaz | 1970 |
Relationships between pyridoxal phosphate availability, activity of vitamin B 6 -dependent enzymes and convulsions.
Topics: Alanine Transaminase; Aminobutyrates; Animals; Aspartate Aminotransferases; Brain; Carboxy-Lyases; D | 1971 |
Vitamin B 6 -dependency of glutamic acid decarboxylase in the kidney from a patient with vitamin B 6 dependent convulsion.
Topics: Aminobutyrates; Carbon Isotopes; Carboxy-Lyases; Glutamates; Humans; Infant; Kidney; Male; Pyridoxin | 1971 |
Encephalopathy following accidental isoniazid poisoning.
Topics: Brain Chemistry; Brain Diseases; Child, Preschool; Humans; Isoniazid; Male; Phenobarbital; Pyridoxin | 1971 |
[On acute isoniazid poisoning on the basis of 2 successfully treated cases].
Topics: Adult; Alcoholism; Blood Transfusion; Brain; Brain Edema; Gastric Lavage; Glucose; Glutamates; Human | 1967 |
[Relationship between convulsions induced by toxic substances and anticonvulsants].
Topics: Acetazolamide; Anilides; Animals; Anticonvulsants; Female; Methacholine Compounds; Mice; Pentylenete | 1967 |
Seizures in experimental porphyria.
Topics: Amides; Animals; Female; Isoniazid; Porphyrias; Porphyrins; Pyridoxal Phosphate; Pyridoxine; Rats; S | 1968 |
The dilute locus, pyridoxine deficiency, and audiogenic seizures in mice.
Topics: Animals; Diet; Female; Genes; Male; Mice; Noise; Pyridoxine; Seizures; Vitamin B 6 Deficiency | 1968 |
Effect of pyridoxine treatment in children with epilepsy.
Topics: Adolescent; Child; Epilepsy; Female; Humans; Male; Pyridoxine; Seizures; Vitamin B 6 Deficiency | 1968 |
Liver kynureninase activity of an infant with infantile spasm.
Topics: Aspartate Aminotransferases; Cerebral Palsy; Child; Child, Preschool; Erythrocytes; Female; Humans; | 1968 |
The biochemical and clinical effect of pyridoxine in children with brain disorders.
Topics: Aminohippuric Acids; Child; Child, Preschool; Female; Humans; Infant; Intellectual Disability; Kynur | 1968 |
Effect of vitamin B6 deficiency on leucine transaminase activity in chick tissue.
Topics: Animals; Anorexia Nervosa; Ataxia; Body Weight; Brain; Chickens; Diet; Growth Disorders; Humans; Kid | 1969 |
Evidence against pyridoxine deficiency as the mechanism of penicillin seizures.
Topics: Animals; Cats; Cerebral Cortex; Electroencephalography; Methanol; Penicillamine; Penicillins; Pyridi | 1969 |
[Therapy of occasional convulsions in children and adolescents].
Topics: Adolescent; Age Factors; Anticonvulsants; Calcium; Child; Humans; Infant, Newborn; Infant, Newborn, | 1969 |
[Acute isoniazid poisoning. Points of onset in the macro-organism, symptoms and measures of treatment].
Topics: Amino Acids; Ammonia; Animals; Barbiturates; Biochemical Phenomena; Biochemistry; Blood; Hexobarbita | 1965 |
Pyridoxine dependency convulsions in a newborn.
Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Meconium; Pyridoxine; Respiratory | 1966 |
In vivo studies of hydrazines and B6-hydrazone-induced convulsions.
Topics: Animals; Chemistry, Organic; Drug Synergism; Hydrazines; Mice; Organic Chemistry Phenomena; Pyridoxi | 1966 |
Vitamin B6 and the toxicity of 1,1-dimethylhydrazine.
Topics: Animals; Coenzymes; Hydrazines; Injections; Injections, Intraperitoneal; Male; Mortality; Pyridoxal | 1966 |