pyridoxine has been researched along with Retinal Degeneration in 23 studies
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
Retinal Degeneration: A retrogressive pathological change in the retina, focal or generalized, caused by genetic defects, inflammation, trauma, vascular disease, or aging. Degeneration affecting predominantly the macula lutea of the retina is MACULAR DEGENERATION. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p304)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Five patients, ages 12 to 30, with gyrate atrophy have shown substantial (60% or greater) decreases in plasma ornithine concentrations within four to eight weeks when placed on a therapeutic trial of low-protein (10-15 g/day), low-arginine diets supplemented with essential amino acids (EAA) and pyridoxine hydrochloride." | 7.66 | Ocular findings in patients with gyrate atrophy on pyridoxine and low-protein, low-arginine diets. ( Berson, EL; Shih, VE; Sullivan, PL, 1981) |
| "Gyrate atrophy is a rare autosomal recessive disorder caused by a mutation in the ornithine-δ-amino transferase gene." | 3.88 | Unique case of gyrate atrophy with a well-preserved electroretinogram (ERG). ( Black, G; Jasani, KM; Kelly, SP; Parry, NRA, 2018) |
| "The purpose of this study was to characterize the mutant enzyme in nine patients with gyrate atrophy of the choroid and retina associated with ornithine aminotransferase (OAT) deficiency, to elucidate the mechanism of response to pyridoxine in four pyridoxine-responsive patients, and to determine the extent of genetic heterogeneity in both groups of patients." | 3.67 | Gyrate atrophy of the choroid and retina: characterization of mutant ornithine aminotransferase and mechanism of response to vitamin B6. ( Kennaway, NG; Stankova, L; Weleber, RG; Wirtz, MK, 1989) |
| "Seven patients with gyrate atrophy and deficiency of ornithine-delta-aminotransferase were studied for in vivo pyridoxine responsiveness; three responded to oral vitamin B6 with over 50% reduction of serum ornithine levels and return to normal of serum lysine levels." | 3.66 | Clinical trial of vitamin B6 for gyrate atrophy of the choroid and retina. ( Kennaway, NG; Weleber, RG, 1981) |
| "Five patients, ages 12 to 30, with gyrate atrophy have shown substantial (60% or greater) decreases in plasma ornithine concentrations within four to eight weeks when placed on a therapeutic trial of low-protein (10-15 g/day), low-arginine diets supplemented with essential amino acids (EAA) and pyridoxine hydrochloride." | 3.66 | Ocular findings in patients with gyrate atrophy on pyridoxine and low-protein, low-arginine diets. ( Berson, EL; Shih, VE; Sullivan, PL, 1981) |
| " Additionally, one of our patients responded to high dosage vitamin B6 with a 27% reduction in plasma ornithine." | 1.26 | Clinical and biochemical heterogeneity in gyrate atrophy. ( Bron, AJ; Kaiser-Kupfer, MI; Valle, D, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (95.65) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jasani, KM | 1 |
| Parry, NRA | 1 |
| Black, G | 1 |
| Kelly, SP | 1 |
| CACIOPPO, F | 1 |
| Shigetomi, S | 1 |
| Hashimoto, S | 1 |
| Gotoh, M | 1 |
| Ueno, S | 1 |
| Fukuchi, S | 1 |
| Weleber, RG | 4 |
| Kennaway, NG | 4 |
| Tada, K | 1 |
| Saito, T | 1 |
| Omura, K | 1 |
| Hayasaka, S | 1 |
| Mizuno, K | 1 |
| Behrens-Baumann, W | 1 |
| König, U | 1 |
| Schröder, K | 1 |
| Hansmann, I | 1 |
| Langenbeck, U | 1 |
| Valle, D | 2 |
| Kaiser-Kupfer, M | 1 |
| Mikhaĭlovskaia, IE | 1 |
| Salganik, RI | 1 |
| Berson, EL | 5 |
| Shih, VE | 5 |
| Sullivan, PL | 1 |
| Gargiulo, M | 1 |
| Kaiser-Kupfer, MI | 1 |
| Bron, AJ | 1 |
| Buist, NR | 1 |
| Mozhaĭtsev, BN | 1 |
| Schmidt, SY | 1 |
| Lipkan, GN | 1 |
| Umovist, NM | 1 |
| Stankova, L | 1 |
| Wirtz, MK | 1 |
| Mandell, R | 1 |
| Ramesh, V | 1 |
| McClatchey, AI | 1 |
| Ramesh, N | 1 |
| Benoit, LA | 1 |
| Gusella, JF | 1 |
| Inana, G | 1 |
| Hotta, Y | 1 |
| Zintz, C | 1 |
| Takki, K | 1 |
| Nakayasu, K | 1 |
| Nakajima, A | 1 |
| Shiono, T | 1 |
| Gerding, H | 1 |
| Hennekes, R | 1 |
| Ullrich, K | 1 |
| Obara, Y | 1 |
| Matsuzawa, T | 1 |
| Kuba, N | 1 |
| Fujita, K | 1 |
| Verin, P | 1 |
| Sekkat, A | 1 |
| Lagoutte, F | 1 |
| Boudet, C | 1 |
| Philippot, M | 1 |
| Arnaud, B | 1 |
1 review available for pyridoxine and Retinal Degeneration
| Article | Year |
|---|---|
Gyrate atrophy of the choroid and retina.
Topics: Arginine; Choroid; Creatine; Diet; Genes, Recessive; Humans; Ornithine; Ornithine-Oxo-Acid Transamin | 1982 |
1 trial available for pyridoxine and Retinal Degeneration
| Article | Year |
|---|---|
[The clinical applications in opthalmology of an original factor in cellular nutrition (piridoxylate].
Topics: Administration, Oral; Aged; Clinical Trials as Topic; Eye Diseases; Female; Glaucoma; Glyoxylates; H | 1974 |
21 other studies available for pyridoxine and Retinal Degeneration
| Article | Year |
|---|---|
Unique case of gyrate atrophy with a well-preserved electroretinogram (ERG).
Topics: Adult; Cataract; Cataract Extraction; Diet, Protein-Restricted; Disease Progression; Electroretinogr | 2018 |
[Separation and paper chromatography of pyridoxine and its derivatives pyridoxal and pyridoxamine].
Topics: Chromatography, Paper; Pyridoxal; Pyridoxamine; Pyridoxine; Retinal Degeneration; Vitamin B 6 | 1951 |
[A case of vitamin B6 dependent homocystinuria with primary pigmentary degeneration of retina, and cerebral thrombosis].
Topics: Homocystinuria; Humans; Hypertension; Intracranial Embolism and Thrombosis; Male; Middle Aged; Pyrid | 1984 |
Clinical trial of vitamin B6 for gyrate atrophy of the choroid and retina.
Topics: Analysis of Variance; Atrophy; Choroid; Dose-Response Relationship, Drug; Electroretinography; Human | 1981 |
Hyperornithinaemia associated with gyrate atrophy of the choroid and retina: in vivo and in vitro response to vitamin B6.
Topics: Adolescent; Child; Child, Preschool; Choroid; Fibroblasts; Humans; Lymphocytes; Male; Ornithine; Orn | 1981 |
Biochemical and therapeutical studies in a case of atrophia gyrata.
Topics: Adult; Atrophy; Choroid; Humans; Lysine; Male; Ornithine; Ornithine-Oxo-Acid Transaminase; Pedigree; | 1982 |
[Treatment of tapetoretinal dystrophy with an adenosine triphosphoric acid preparation].
Topics: Adenosine Triphosphate; Adolescent; Adult; Child; Diathermy; Drug Evaluation; Drug Therapy, Combinat | 1982 |
Ocular findings in patients with gyrate atrophy on pyridoxine and low-protein, low-arginine diets.
Topics: Adolescent; Adult; Arginine; Atrophy; Child; Choroid; Dark Adaptation; Dietary Proteins; Electroreti | 1981 |
Reduction of hyperornithinemia with a low protein, low arginine diet and pyridoxine in patients with a deficiency of ornithine-ketoacid transaminase (OKT) activity and gyrate atrophy of the choroid and retina.
Topics: Adolescent; Adult; Amino Acids, Essential; Arginine; Child; Choroid; Dietary Proteins; Female; Human | 1981 |
Clinical and biochemical heterogeneity in gyrate atrophy.
Topics: Adolescent; Adult; Atrophy; Cataract; Child; Choroid; Female; Genes; Humans; Ornithine; Ornithine-Ox | 1980 |
Vitamin B6 in management of gyrate atrophy of choroid and retina.
Topics: Administration, Oral; Atrophy; Choroid; Drug Evaluation; Humans; In Vitro Techniques; Ornithine-Oxo- | 1978 |
[Use of vitamin B6 in the overall treatment of elderly patients with primary dystrophies of the central portion of the fundus oculi].
Topics: Aged; Arteriosclerosis; Female; Fundus Oculi; Humans; Male; Middle Aged; Pyridoxine; Retinal Degener | 1978 |
Ocular and biochemical abnormalities in gyrate atrophy of the choroid and retina.
Topics: Administration, Oral; Adolescent; Adult; Amino Acids; Atrophy; Child; Choroid; Dark Adaptation; Elec | 1978 |
[Effect of vitamin B 6 therapy on blood coagulation indicators in patients with arteriosclerotic dystrophy of macula lutea].
Topics: Adult; Arteriosclerosis; Blood Coagulation; Female; Humans; Macular Degeneration; Male; Middle Aged; | 1975 |
Gyrate atrophy of the choroid and retina: characterization of mutant ornithine aminotransferase and mechanism of response to vitamin B6.
Topics: Atrophy; Cells, Cultured; Choroid; Enzyme Stability; Humans; Kinetics; Mutation; Ornithine-Oxo-Acid | 1989 |
Pyridoxine effects on ornithine ketoacid transaminase activity in fibroblasts from carriers of two forms of gyrate atrophy of the choroid and retina.
Topics: Atrophy; Cell Line; Choroid; Enzyme Stability; Fibroblasts; Heterozygote; Humans; Ornithine-Oxo-Acid | 1988 |
Molecular basis of ornithine aminotransferase deficiency in B-6-responsive and -nonresponsive forms of gyrate atrophy.
Topics: Cloning, Molecular; DNA; Gene Expression Regulation; Humans; Ornithine-Oxo-Acid Transaminase; Pyrido | 1988 |
Expression defect of ornithine aminotransferase gene in gyrate atrophy.
Topics: Choroid; DNA; Fibroblasts; Gene Expression Regulation; Humans; Leukocytes; Nucleic Acid Hybridizatio | 1988 |
[Therapy of atrophia gyrata].
Topics: Adult; Choroid; Female; Genes, Recessive; Humans; Pyridoxine; Retinal Degeneration | 1987 |
Retinal damage in hatched chicks induced by formoguanamine. Decrease in ornithine aminotransferase activity and vitamin B6 content.
Topics: Animals; Chickens; Glutathione Transferase; Male; Ornithine-Oxo-Acid Transaminase; Pigment Epitheliu | 1985 |
[Clinical experimentation with pyridoxylate in treatment of various chorioretinal degenerative disorders (50 cases)].
Topics: Adult; Aged; Choroid; Diabetic Retinopathy; Glaucoma; Glyoxylates; Humans; Middle Aged; Pyridoxine; | 1969 |