pyridoxine has been researched along with Pregnancy in 633 studies
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Doxylamine-pyridoxine is recommended as a first line treatment for nausea and vomiting during pregnancy and it is commonly prescribed." | 9.27 | Doxylamine-pyridoxine for nausea and vomiting of pregnancy randomized placebo controlled trial: Prespecified analyses and reanalysis. ( El-Emam, K; Meaney, C; Moineddin, R; Persaud, N; Thorpe, K, 2018) |
| "We report information about an unpublished 1970s study ("8-way" Bendectin Study) that aimed to evaluate the relative therapeutic efficacy of doxylamine, pyridoxine, and dicyclomine in the management of nausea and vomiting during pregnancy." | 9.24 | 8-Way Randomized Controlled Trial of Doxylamine, Pyridoxine and Dicyclomine for Nausea and Vomiting during Pregnancy: Restoration of Unpublished Information. ( Persaud, N; Zhang, R, 2017) |
| "Doxylamine succinate-pyridoxine hydrochloride delayed release combination is safe and well tolerated by pregnant women when used in the recommended dose of up to 4 tablets daily in treating nausea and vomiting of pregnancy." | 9.20 | Maternal safety of the delayed-release doxylamine and pyridoxine combination for nausea and vomiting of pregnancy; a randomized placebo controlled trial. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Matok, I; Mattison, DR; Miodovnik, M; Umans, JG, 2015) |
| " This was a pre-specified substudy of a randomized, placebo-controlled trial comparing the antiemetic effect of the doxylamine-vitamin B6 combination (Diclectin®) (n = 131) to placebo (n = 126) in women with nausea and vomiting of pregnancy." | 9.19 | Studying the antiemetic effect of vitamin B6 for morning sickness: pyridoxine and pyridoxal are prodrugs. ( Caritis, S; Clark, S; Hankins, G; Koren, G; Matok, I; Mattison, DR; Miodovnik, M; Umans, JG, 2014) |
| "Our investigation showed ondansetron to be superior to the combination of pyridoxine and doxylamine in the treatment of nausea and emesis in pregnancy." | 9.19 | Ondansetron compared with doxylamine and pyridoxine for treatment of nausea in pregnancy: a randomized controlled trial. ( Capp, SM; Carstairs, SD; Oliveira, LG; Riffenburgh, RH; You, WB, 2014) |
| "Although Diclectin (doxylamine/pyridoxine delayed-released combination) is widely used in Canada, its pharmacokinetics (PK) during pregnancy has never been described." | 9.17 | Comparing the pharmacokinetics of doxylamine/pyridoxine delayed-release combination in nonpregnant women of reproductive age and women in the first trimester of pregnancy. ( Caritis, S; Clark, S; Hankins, G; Koren, G; Matok, I; Miodovnik, M; Umans, J, 2013) |
| " The authors' objective is to identify the determinants of adherence to delayed-release doxylamine-pyridoxine (Diclectin) in patients with nausea and vomiting of pregnancy (NVP)." | 9.16 | Determinants of adherence to delayed-release doxylamine and pyridoxine in patients with nausea and vomiting of pregnancy. ( Caritis, S; Chiossi, G; Clark, S; Costantine, MM; Hankins, GD; Koren, G; Matok, I; Miodovnik, M; Umans, JG, 2012) |
| "To evaluate oral pyridoxine in conjunction with standard therapy in women hospitalized for hyperemesis gravidarum (HG)." | 9.14 | A placebo-controlled trial of oral pyridoxine in hyperemesis gravidarum. ( Omar, SZ; Tan, PC; Yow, CM, 2009) |
| "To evaluate the effectiveness of Diclectin (doxylamine succinate 10 mg-pyridoxine hydrochloride 10 mg, delayed-release preparation) as compared with placebo for nausea and vomiting of pregnancy." | 9.14 | Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Mattison, DR; Miodovnik, M; Umans, JG, 2010) |
| "Our purpose was to determine the effectiveness of pyridoxine for nausea and vomiting of pregnancy." | 9.08 | Pyridoxine for nausea and vomiting of pregnancy: a randomized, double-blind, placebo-controlled trial. ( Ruangsri, R; Vutyavanich, T; Wongtra-ngan, S, 1995) |
| "Our purpose was to study maternal blood and amniotic fluid concentrations of homocysteine and relevant vitamins in relation to neural tube defects." | 9.08 | Neural tube defects and elevated homocysteine levels in amniotic fluid. ( Blom, HJ; Boers, GH; Borm, GF; Eskes, TK; Nijhuis, JG; Steegers-Theunissen, RP; Thomas, CM, 1995) |
| "Our purpose was to assess the incidence of hyperhomocysteinemia in patients with a history of preeclampsia or fetal growth restriction, to evaluate the effects of vitamin supplementation on the methionine loading test, and to study the course of subsequent pregnancies in women with hyperhomocysteinemia and a history of preeclampsia or fetal growth restriction." | 9.08 | Effects of folic acid and vitamin B6 supplementation on women with hyperhomocysteinemia and a history of preeclampsia or fetal growth restriction. ( de Vries, JI; Dekker, GA; Jakobs, C; Leeda, M; Riyazi, N; van Geijn, HP, 1998) |
| "The effect of maternal pyridoxine X HCl (PN-HCl) supplementation on the vitamin B-6 status of pregnant women and their infants at birth and on pregnancy outcome was investigated." | 9.05 | Effect of maternal pyridoxine X HCl supplementation on the vitamin B-6 status of mother and infant and on pregnancy outcome. ( Bailey, LB; Mahan, CS; Schuster, K, 1984) |
| " We did not find any statistically significant differences in the risk of eclampsia (capsules: n = 1242; three trials; lozenges: n = 944; one trial), pre-eclampsia (capsules n = 1197; two trials, low quality of evidence; lozenges: n = 944; one trial, low-quality evidence) or low Apgar scores at one minute (oral pyridoxine: n = 45; one trial), between supplemented and non-supplemented groups." | 8.91 | Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes. ( Bhutta, ZA; Salam, RA; Zuberi, NF, 2015) |
| "There is not enough evidence to evaluate pyridoxine supplementation during pregnancy, although the results of one trial suggest that it may have a beneficial effect on dental decay." | 8.80 | Pyridoxine (vitamin B6) supplementation in pregnancy. ( Gulmezoglu, AM; Mahomed, K, 2000) |
| "Doxylamine-pyridoxine is the first-line agent for the treatment of nausea and vomiting of pregnancy (NVP) according to Canadian guidelines, and this combination is commonly prescribed to pregnant women." | 7.80 | Should doxylamine-pyridoxine be used for nausea and vomiting of pregnancy? ( Chin, J; Persaud, N; Walker, M, 2014) |
| "Diclectin (pyridoxine 10 mg and doxylamine 10 mg) has traditionally been used to treat nausea and vomiting of pregnancy (NVP); however, this drug is unavailable in many countries." | 7.79 | Evaluation of the efficacy and safety of bi-daily combination therapy with pyridoxine and doxylamine for nausea and vomiting of pregnancy. ( Ashkenazi-Hoffnung, L; Klinger, G; Merlob, P; Stahl, B, 2013) |
| "The US FDA approval in April 2013 of Diclegis®, the doxylamine-pyridoxine combination for morning sickness, is a major milestone, particularly since it is indicated for use in pregnancy and the FDA has labeled it a pregnancy category A drug the strongest evidence of fetal safety." | 7.79 | The return to the USA of doxylamine-pyridoxine delayed release combination (Diclegis®) for morning sickness--a new morning for American women. ( Koren, G, 2013) |
| "The long-term outcome of the Dutch pyridoxine-dependent epilepsy cohort and correlations between patient characteristics and follow-up data were retrospectively studied." | 7.78 | Long-term outcome in pyridoxine-dependent epilepsy. ( Bok, LA; Halbertsma, FJ; Houterman, S; Jakobs, C; Sival, DA; Struys, E; Van Der Hoeven, JH; Vreeswijk, C; Wevers, RA; Willemsen, MA, 2012) |
| "Pyridoxine-dependent epilepsy (PDE) is a treatable inborn error of metabolism with autosomal recessive inheritance." | 7.77 | Status epilepticus in a neonate treated with pyridoxine because of a familial recurrence risk for antiquitin deficiency: pyridoxine toxicity? ( Fingerhut, M; Hartmann, H; Jakobs, C; Plecko, B, 2011) |
| "Incidental reports suggest that antenatal treatment of pyridoxine dependent seizures (PDS) may improve neurodevelopmental outcome of affected patients." | 7.76 | Antenatal treatment in two Dutch families with pyridoxine-dependent seizures. ( Been, JV; Bok, LA; Jakobs, C; Rijper, EA; Struys, EA; Willemsen, MA, 2010) |
| "Some studies of children with Down syndrome have found mild abnormalities in the metabolism of pyridoxine (vitamin B(6)); therefore the present question is whether such abnormalities might also be present in the amniotic fluid of fetuses with Down syndrome." | 7.74 | Pyridoxine-related metabolite concentrations in normal and Down syndrome amniotic fluid. ( Baggot, PJ; DeNicola, NG; Eliseo, AJ; Kalamarides, JA; Shoemaker, JD, 2008) |
| "To study the human risk and benefit of oral pyridoxine (vitamin B6) treatment during pregnancy." | 7.72 | Oral pyridoxine during pregnancy : potential protective effect for cardiovascular malformations. ( Acs, N; Bánhidy, F; Czeizel, AE; Puhó, E, 2004) |
| "A delayed-release combination of doxylamine-pyridoxine (D-P) (Diclectin) is the only approved antiemetic medication for use in pregnancy in Canada." | 7.71 | The safety of higher than standard dose of doxylamine-pyridoxine (Diclectin) for nausea and vomiting of pregnancy. ( Atanackovic, G; Koren, G; Moretti, ME; Navioz, Y, 2001) |
| "To evaluate the adequacy of maternal pyridoxine supplementation during pregnancy for both maternal and neonatal status at birth, vitamin B6 status, assessed by plasma pyridoxal phosphate (PLP), pyridoxal (PL) and total aldehyde vitamer (PLP + PL) concentrations, and the growth of neonates, including weight, length, head and chest circumferences, were examined for 209 neonates whose mothers were supplemented with 0, 1, 2 or 3 mg pyridoxine." | 7.70 | Adequacy of maternal pyridoxine supplementation during pregnancy in relation to the vitamin B6 status and growth of neonates at birth. ( Chang, SJ, 1999) |
| " The pregnancy was complicated by chronic maternal schizophrenia, severe toxaemia and maternal use of fluphenazine enanthate, dicyclomine hydrochloride, doxylamine succinate, pyridoxine hydrochloride and other drugs." | 7.66 | Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy. ( Bury, RG; Donaldson, GL, 1982) |
| "Administration of Vitamin B6 during gestation to mice on a Vitamin B6-containing diet resulted in a substantial reduction in cortisone-induced cleft palate." | 7.66 | Vitamin B6 reduces cortisone-induced cleft palate in the mouse. ( Pratt, RM; Yoneda, T, 1982) |
| "Sixteen patients, eight with acromegaly and eight with galactorrhea, were treated with pyridoxine (600 mg/day) for a three-month period." | 7.66 | Superiority of bromocriptine over pyridoxine in the treatment of patients with acromegaly or galactorrhea. ( Blum, I; Chowers, I; Kaufman, H; Sagiv, M; Segal, S; Shalit, M, 1980) |
| "Thirteen women with chemical diabetes diagnosed in late pregnancy were found to excrete excessive amounts of urinary xanthurenic acid after a tryptophan load, indicative of a relative pyridoxine (vitamin B6) deficiency." | 7.66 | Pyridoxine treatment of chemical diabetes in pregnancy. ( Gillmer, MD; Mazibuko, D, 1979) |
| "The acute effect of pyridoxine (B6) on serum GH and PRL levels and its chronic effects on galactorrhea in nine subjects (group I, n=4, idiopathic galactorrhea with normal PRL levels and normal menses; Group II, n=5, galactorrhea-amenorrhea with increased PRL levels) have been studied." | 7.65 | Ineffectiveness of pyridoxine (B6) to alter secretion of growth hormone and prolactin and absence of therapeutic effects on galactorrhea-amenorrhea syndromes. ( Guyda, H; Laliberté, R; Naftolin, F; Tolis, G, 1977) |
| "Three women with the galactorrhea-amenorrhea syndrome and elevated prolactin concentrations experienced a return of regular ovulatory menses within 37-94 days after starting pyridoxine treatment (200-600 mg/day)." | 7.65 | Treatment of women with the galactorrhea-amenorrhea syndrome with pyridoxine (vitamin B6). ( McIntosh, EN, 1976) |
| "The effect of different amounts of vitamin B6 supplementation during pregnancy on maternal and fetal plasma levels of pyridoxal phosphate (PLP) at term has been studied." | 7.65 | Maternal and fetal plasma levels of pyridoxal phosphate at term: adequacy of vitamin B6 supplementation during pregnancy. ( Cleary, RE; Li, TK; Lumeng, L, 1975) |
| "An effective and safe treatment for nausea and vomiting of pregnancy (NVP) is lacking." | 7.30 | Acupuncture and Doxylamine-Pyridoxine for Nausea and Vomiting in Pregnancy : A Randomized, Controlled, 2 ( An, CM; Cao, YJ; Chen, XY; Cong, J; Cui, YM; Feng, YH; Gao, JS; Hu, YH; Li, J; Li, L; Liu, JP; Liu, L; Liu, YX; Liu, ZL; Liu, ZS; Lu, ZL; Ma, HL; Mol, BWJ; Ng, EHY; Painter, RC; Qi, X; Qin, HC; Wang, CC; Wang, Y; Wang, YX; Wu, Q; Wu, XK; Yan, Y; Yang, XM; Yu, L; Zhang, B; Zhou, LL, 2023) |
| " Study drug dosing occurred for 14 days, which is substantially longer than what has been performed in similar studies." | 6.82 | Demonstration of early efficacy results of the delayed-release combination of doxylamine-pyridoxine for the treatment of nausea and vomiting of pregnancy. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Matok, I; Mattison, DR; Miodovnik, M; Umans, JG, 2016) |
| " Pharmacokinetic parameters were calculated for each study period using standard, non-compartmental methods, and differences were assessed using ANOVA." | 6.78 | Sex differences in the pharmacokinetics and bioequivalence of the delayed-release combination of doxylamine succinate-pyridoxine hydrochloride; implications for pharmacotherapy in pregnancy. ( Gill, SK; Koren, G; Macleod, S; Vranderick, M, 2013) |
| "Doxylamine-pyridoxine is recommended as a first line treatment for nausea and vomiting during pregnancy and it is commonly prescribed." | 5.27 | Doxylamine-pyridoxine for nausea and vomiting of pregnancy randomized placebo controlled trial: Prespecified analyses and reanalysis. ( El-Emam, K; Meaney, C; Moineddin, R; Persaud, N; Thorpe, K, 2018) |
| ""Perinatal" hypophosphatasia is the most severe form of this inborn error of metabolism, which is characterized by deficient activity of the tissue-nonspecific (liver/bone/kidney) isoenzyme of alkaline phosphatase (ALP) (TNSALP)." | 5.27 | Perinatal hypophosphatasia: tissue levels of vitamin B6 are unremarkable despite markedly increased circulating concentrations of pyridoxal-5'-phosphate. Evidence for an ectoenzyme role for tissue-nonspecific alkaline phosphatase. ( Coburn, SP; Cole, FS; Fedde, KN; Mahuren, JD; McCabe, ER; Whyte, MP, 1988) |
| "Pyridoxine hydrochloride was gavaged to 2 groups of pregnant Wistar rats from day 0 to 13 and day 6 to 15 of gestation at doses of 100, 200, 400 and 800 mg/kg." | 5.27 | Effects of pyridoxine on implantation and pregnancy in Wistar rat. ( Marathe, MR; Thomas, GP, 1987) |
| "We report information about an unpublished 1970s study ("8-way" Bendectin Study) that aimed to evaluate the relative therapeutic efficacy of doxylamine, pyridoxine, and dicyclomine in the management of nausea and vomiting during pregnancy." | 5.24 | 8-Way Randomized Controlled Trial of Doxylamine, Pyridoxine and Dicyclomine for Nausea and Vomiting during Pregnancy: Restoration of Unpublished Information. ( Persaud, N; Zhang, R, 2017) |
| "Doxylamine succinate-pyridoxine hydrochloride delayed release combination is safe and well tolerated by pregnant women when used in the recommended dose of up to 4 tablets daily in treating nausea and vomiting of pregnancy." | 5.20 | Maternal safety of the delayed-release doxylamine and pyridoxine combination for nausea and vomiting of pregnancy; a randomized placebo controlled trial. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Matok, I; Mattison, DR; Miodovnik, M; Umans, JG, 2015) |
| " This was a pre-specified substudy of a randomized, placebo-controlled trial comparing the antiemetic effect of the doxylamine-vitamin B6 combination (Diclectin®) (n = 131) to placebo (n = 126) in women with nausea and vomiting of pregnancy." | 5.19 | Studying the antiemetic effect of vitamin B6 for morning sickness: pyridoxine and pyridoxal are prodrugs. ( Caritis, S; Clark, S; Hankins, G; Koren, G; Matok, I; Mattison, DR; Miodovnik, M; Umans, JG, 2014) |
| "Our investigation showed ondansetron to be superior to the combination of pyridoxine and doxylamine in the treatment of nausea and emesis in pregnancy." | 5.19 | Ondansetron compared with doxylamine and pyridoxine for treatment of nausea in pregnancy: a randomized controlled trial. ( Capp, SM; Carstairs, SD; Oliveira, LG; Riffenburgh, RH; You, WB, 2014) |
| "Although Diclectin (doxylamine/pyridoxine delayed-released combination) is widely used in Canada, its pharmacokinetics (PK) during pregnancy has never been described." | 5.17 | Comparing the pharmacokinetics of doxylamine/pyridoxine delayed-release combination in nonpregnant women of reproductive age and women in the first trimester of pregnancy. ( Caritis, S; Clark, S; Hankins, G; Koren, G; Matok, I; Miodovnik, M; Umans, J, 2013) |
| " The authors' objective is to identify the determinants of adherence to delayed-release doxylamine-pyridoxine (Diclectin) in patients with nausea and vomiting of pregnancy (NVP)." | 5.16 | Determinants of adherence to delayed-release doxylamine and pyridoxine in patients with nausea and vomiting of pregnancy. ( Caritis, S; Chiossi, G; Clark, S; Costantine, MM; Hankins, GD; Koren, G; Matok, I; Miodovnik, M; Umans, JG, 2012) |
| "To evaluate oral pyridoxine in conjunction with standard therapy in women hospitalized for hyperemesis gravidarum (HG)." | 5.14 | A placebo-controlled trial of oral pyridoxine in hyperemesis gravidarum. ( Omar, SZ; Tan, PC; Yow, CM, 2009) |
| "The delayed-release combination of doxylamine succinate and pyridoxine hydrochloride was the most commonly used antiemetic (Bendectin) approved by FDA for nausea and vomiting of pregnancy (NVP) until its removal of the market in 1983." | 5.14 | Pharmacokinetic comparison of a delayed-release combination of doxylamine succinate and pyridoxine hydrocholoride (Diclectin) and oral solutions of these drugs in healthy women of childbearing age. ( Koren, G; Nulman, I, 2009) |
| "To evaluate the effectiveness of Diclectin (doxylamine succinate 10 mg-pyridoxine hydrochloride 10 mg, delayed-release preparation) as compared with placebo for nausea and vomiting of pregnancy." | 5.14 | Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Mattison, DR; Miodovnik, M; Umans, JG, 2010) |
| " We used as a motivating example the possible teratogenic risks of antiemetic agents in pregnancy since a large observational study recently showed that first-trimester exposure to doxylamine-pyridoxine was associated with significantly increased risk of congenital malformations as a whole, as well as central nervous system defects, and previous observational studies did not show such associations." | 5.12 | Misleading meta-analyses of observational studies may generate unjustified alarms: The case of medications for nausea and vomiting in pregnancy. ( Biffi, A; Cetin, I; Corrao, G; Filippelli, A; Locatelli, A; Rea, F, 2021) |
| " The NVP Healthline enrolled two control groups of women with NVP treated with a doxylamine-pyridoxine combination for morning sickness." | 5.11 | Is lack of morning sickness teratogenic? A prospective controlled study. ( Boskovic, R; Danieliewska-Nikiel, B; Koren, G; Navioz, Y; Rudic, N, 2004) |
| "This study compares pyridoxine-metoclopramide combination therapy to prochlorperazine and promethazine monotherapies in the outpatient treatment of nausea and vomiting in pregnancy." | 5.10 | Comparison of three outpatient regimens in the management of nausea and vomiting in pregnancy. ( Bsat, FA; Hoffman, DE; Seubert, DE, 2003) |
| "Our purpose was to determine the effectiveness of pyridoxine for nausea and vomiting of pregnancy." | 5.08 | Pyridoxine for nausea and vomiting of pregnancy: a randomized, double-blind, placebo-controlled trial. ( Ruangsri, R; Vutyavanich, T; Wongtra-ngan, S, 1995) |
| "Our purpose was to study maternal blood and amniotic fluid concentrations of homocysteine and relevant vitamins in relation to neural tube defects." | 5.08 | Neural tube defects and elevated homocysteine levels in amniotic fluid. ( Blom, HJ; Boers, GH; Borm, GF; Eskes, TK; Nijhuis, JG; Steegers-Theunissen, RP; Thomas, CM, 1995) |
| " A randomized, triple-blinded controlled trial of 124 women was done to evaluate the effect of taking 150 mg of vitamin B6 daily for 30 days on the severity of nausea, headache, vomiting, dizziness, depression, and irritability associated with the initiation of low-dose (30 micrograms norgestrel and 30 micrograms ethinyl estradiol) OG use." | 5.08 | Effect of vitamin B6 on the side effects of a low-dose combined oral contraceptive. ( Grubb, GS; Juárez-Perez, MA; Ponce de León, R; Villegas-Salas, E, 1997) |
| "Our purpose was to assess the incidence of hyperhomocysteinemia in patients with a history of preeclampsia or fetal growth restriction, to evaluate the effects of vitamin supplementation on the methionine loading test, and to study the course of subsequent pregnancies in women with hyperhomocysteinemia and a history of preeclampsia or fetal growth restriction." | 5.08 | Effects of folic acid and vitamin B6 supplementation on women with hyperhomocysteinemia and a history of preeclampsia or fetal growth restriction. ( de Vries, JI; Dekker, GA; Jakobs, C; Leeda, M; Riyazi, N; van Geijn, HP, 1998) |
| "Fifty-nine women completed a randomized, double-blind placebo-controlled study of pyridoxine hydrochloride (vitamin B6) for the treatment of nausea and vomiting of pregnancy." | 5.07 | Vitamin B6 is effective therapy for nausea and vomiting of pregnancy: a randomized, double-blind placebo-controlled study. ( Niebyl, J; Rose, N; Rouse, D; Sahakian, V; Sipes, S, 1991) |
| "The effect of maternal pyridoxine X HCl (PN-HCl) supplementation on the vitamin B-6 status of pregnant women and their infants at birth and on pregnancy outcome was investigated." | 5.05 | Effect of maternal pyridoxine X HCl supplementation on the vitamin B-6 status of mother and infant and on pregnancy outcome. ( Bailey, LB; Mahan, CS; Schuster, K, 1984) |
| "A double-blind comparison was undertaken between Debendox with 10mg of extra pyridoxine and placebo with 10mg of pyridoxine, in 56 women suffering from nausea and/or vomiting during the first 10 weeks of pregnancy." | 5.04 | Treatment of pregnancy sickness. ( Wheatley, D, 1977) |
| "5, 4, and 10 mg of pyridoxine supplementation during pregnancy on maternal and fetal plasma levels of pyridoxal 5'-phosphate (PLP) and on the degree of coenzyme saturation (activation factor) of aspartate aminotransferase and alanine aminotransferase (alphaEGOT and alphaEGPT) in maternal erythrocytes." | 5.04 | Adequacy of vitamin B6 supplementation during pregnancy: a prospective study. ( Cleary, RE; Lumeng, L; Wagner, R, 1976) |
| "For mild symptoms of nausea and emesis of pregnancy, ginger, pyridoxine, antihistamines, and metoclopramide were associated with greater benefit than placebo." | 4.93 | Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review. ( Beyer, F; Bradley, J; Bryant, A; McParlin, C; Moloney, E; Muirhead, CR; Nelson-Piercy, C; Newbury-Birch, D; Norman, J; O'Donnell, A; Robson, SC; Shaw, C; Simpson, E; Swallow, B; Vale, L; Yates, L, 2016) |
| " We did not find any statistically significant differences in the risk of eclampsia (capsules: n = 1242; three trials; lozenges: n = 944; one trial), pre-eclampsia (capsules n = 1197; two trials, low quality of evidence; lozenges: n = 944; one trial, low-quality evidence) or low Apgar scores at one minute (oral pyridoxine: n = 45; one trial), between supplemented and non-supplemented groups." | 4.91 | Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes. ( Bhutta, ZA; Salam, RA; Zuberi, NF, 2015) |
| "Ten randomized trials studying the effects of acupressure, ginger, and pyridoxine on nausea and vomiting of pregnancy were reviewed." | 4.80 | Alternative therapies for nausea and vomiting of pregnancy. ( Aikins Murphy, P, 1998) |
| ""Bendectin" (Doxylamine/Dicyclomine/Pyridoxine) was widely used for the treatment of nausea and vomiting of pregnancy until 1983, when production was discontinued in the face of lawsuits alleging that the drug caused congenital malformations." | 4.79 | Bendectin and birth defects: I. A meta-analysis of the epidemiologic studies. ( Kutcher, JS; Lamm, SH; Linn, S; McKeigue, PM, 1994) |
| "Cyclizine hydrochloride (CYC) and meclozine hydrochloride (MEC) are antihistaminic drugs generally co-formulated with pyridoxine hydrochloride (PYR) to treat nausea and vomiting in pregnancy." | 4.12 | Impurity-profiling UPLC methods for quantitative analysis of some antiemetics formulated with pyridoxine. ( Abdallah, FF; Draz, ME; Lashien, AS; Naguib, IA; Saad, AS; Zaazaa, HE, 2022) |
| "Using the Quebec Pregnancy Cohort (1998-2015), first-trimester doxylamine-pyridoxine, metoclopramide, and ondansetron exposures were assessed for their association with MCM." | 3.91 | New evidence for concern over the risk of birth defects from medications for nausea and vomitting of pregnancy. ( Bérard, A; Bernatsky, S; Gorgui, J; Sheehy, O; Soares de Moura, C; Zhao, JP, 2019) |
| "In this study, we determined how maternal dietary supplementation with pyridoxine combined with different sources of selenium (Se) affected global gene expression of porcine expanded blastocysts (PEB) during pregnancy." | 3.81 | Gene expression of porcine blastocysts from gilts fed organic or inorganic selenium and pyridoxine. ( Audet, I; Dalto, BD; Dyck, MK; Foxcroft, GR; Matte, JJ; Tsoi, S, 2015) |
| "Doxylamine-pyridoxine is the first-line agent for the treatment of nausea and vomiting of pregnancy (NVP) according to Canadian guidelines, and this combination is commonly prescribed to pregnant women." | 3.80 | Should doxylamine-pyridoxine be used for nausea and vomiting of pregnancy? ( Chin, J; Persaud, N; Walker, M, 2014) |
| "Diclectin (pyridoxine 10 mg and doxylamine 10 mg) has traditionally been used to treat nausea and vomiting of pregnancy (NVP); however, this drug is unavailable in many countries." | 3.79 | Evaluation of the efficacy and safety of bi-daily combination therapy with pyridoxine and doxylamine for nausea and vomiting of pregnancy. ( Ashkenazi-Hoffnung, L; Klinger, G; Merlob, P; Stahl, B, 2013) |
| "The US FDA approval in April 2013 of Diclegis®, the doxylamine-pyridoxine combination for morning sickness, is a major milestone, particularly since it is indicated for use in pregnancy and the FDA has labeled it a pregnancy category A drug the strongest evidence of fetal safety." | 3.79 | The return to the USA of doxylamine-pyridoxine delayed release combination (Diclegis®) for morning sickness--a new morning for American women. ( Koren, G, 2013) |
| "The long-term outcome of the Dutch pyridoxine-dependent epilepsy cohort and correlations between patient characteristics and follow-up data were retrospectively studied." | 3.78 | Long-term outcome in pyridoxine-dependent epilepsy. ( Bok, LA; Halbertsma, FJ; Houterman, S; Jakobs, C; Sival, DA; Struys, E; Van Der Hoeven, JH; Vreeswijk, C; Wevers, RA; Willemsen, MA, 2012) |
| "Diclectin, composed of 10 mg doxylamine succinate (DOX) and 10 mg pyridoxine hydrochloride, is the drug combination of choice for the management of nausea and vomiting during pregnancy in Canada." | 3.77 | Systemic bioavailability and pharmacokinetics of the doxylamine-pyridoxine delayed-release combination (Diclectin). ( Garcia-Bournissen, F; Gill, SK; Koren, G, 2011) |
| "Pyridoxine-dependent epilepsy (PDE) is a treatable inborn error of metabolism with autosomal recessive inheritance." | 3.77 | Status epilepticus in a neonate treated with pyridoxine because of a familial recurrence risk for antiquitin deficiency: pyridoxine toxicity? ( Fingerhut, M; Hartmann, H; Jakobs, C; Plecko, B, 2011) |
| "Incidental reports suggest that antenatal treatment of pyridoxine dependent seizures (PDS) may improve neurodevelopmental outcome of affected patients." | 3.76 | Antenatal treatment in two Dutch families with pyridoxine-dependent seizures. ( Been, JV; Bok, LA; Jakobs, C; Rijper, EA; Struys, EA; Willemsen, MA, 2010) |
| "Some studies of children with Down syndrome have found mild abnormalities in the metabolism of pyridoxine (vitamin B(6)); therefore the present question is whether such abnormalities might also be present in the amniotic fluid of fetuses with Down syndrome." | 3.74 | Pyridoxine-related metabolite concentrations in normal and Down syndrome amniotic fluid. ( Baggot, PJ; DeNicola, NG; Eliseo, AJ; Kalamarides, JA; Shoemaker, JD, 2008) |
| " Additionally, those with thrombophilia or hyperhomocysteinemia were treated with low molecular weight heparin and with pyridoxine and folic acid supplementation, respectively." | 3.73 | Pre-pregnant prediction of recurrent preeclampsia in normotensive thrombophilic formerly preeclamptic women receiving prophylactic antithrombotic medication. ( Aardenburg, R; de Leeuw, PW; Ekhart, TH; Peeters, LL; Spaanderman, ME; van Eyndhoven, HW, 2005) |
| "Male and female rats were given metadoxine before pregnancy and early gestation, i." | 3.72 | [Reproductive toxicity of metadoxine in rats]. ( Chen, JG; Lai, WQ; Mei, S; Wang, Y; Zhang, WY; Zhang, X; Zhu, HJ, 2003) |
| "Women who called the Motherisk NVP helpline, and were taking only Diclectin (vitamin B6 10 mg and doxylamine 10 mg), were enrolled in the study and assessed for the severity of nausea and vomiting of pregnancy (NVP) with the Motherisk-PUQE (pregnancy-unique quantification of emesis and nausea) scoring system." | 3.72 | Diclectin therapy for nausea and vomiting of pregnancy: effects of optimal dosing. ( Boskovic, R; Einarson, A; Koren, G; Maltepe, C; Wolpin, J, 2003) |
| "A delayed-release combination of doxylamine-pyridoxine (D-P) (Diclectin) is the only approved antiemetic medication for use in pregnancy in Canada." | 3.71 | The safety of higher than standard dose of doxylamine-pyridoxine (Diclectin) for nausea and vomiting of pregnancy. ( Atanackovic, G; Koren, G; Moretti, ME; Navioz, Y, 2001) |
| " Folic acid and pyridoxine administration normalized the homocysteine concentration and favored a successful pregnancy." | 3.70 | A woman with five consecutive fetal deaths: case report and retrospective analysis of hyperhomocysteinemia prevalence in 100 consecutive women with recurrent miscarriages. ( Bellet, H; Gris, JC; Hoffet, M; Janbon, C; Mares, P; Quere, I, 1998) |
| ", folate, cobalamin, or pyridoxine) potentiated by maternal dietary deficiency of these cofactors and by pregnancy." | 3.70 | DNA polymorphism-diet-cofactor-development hypothesis and the gene-teratogen model for schizophrenia and other developmental disorders. ( Johnson, WG, 1999) |
| "To evaluate the adequacy of maternal pyridoxine supplementation during pregnancy for both maternal and neonatal status at birth, vitamin B6 status, assessed by plasma pyridoxal phosphate (PLP), pyridoxal (PL) and total aldehyde vitamer (PLP + PL) concentrations, and the growth of neonates, including weight, length, head and chest circumferences, were examined for 209 neonates whose mothers were supplemented with 0, 1, 2 or 3 mg pyridoxine." | 3.70 | Adequacy of maternal pyridoxine supplementation during pregnancy in relation to the vitamin B6 status and growth of neonates at birth. ( Chang, SJ, 1999) |
| " Whenever she decreases her prednisone dose, her nausea increases tremendously even though she is taking two tablets of doxylamine and pyridoxine combination (Diclectin) daily." | 3.70 | Managing women with nausea and vomiting of pregnancy. Canadian consensus. ( , 2000) |
| " Although no definitive causative factor has been identified in previously reported cases, the affection in our case is possibly related to Debendox (Bendectin) and nitrofurantoin taken in early pregnancy for nausea and renal tract infection, respectively." | 3.69 | Congenital symmetrical weakness of the upper limbs resembling brachial plexus palsy: a possible sequel of drug toxicity in first trimester of pregnancy? ( Dubowitz, V; Muntoni, F; Philpot, J; Skellett, S, 1995) |
| "In order to assess the nutritional status of riboflavin and pyridoxine during pregnancy, 24 Mexican women were studied during the second trimester and 17 during the third trimester of gestation." | 3.69 | Riboflavin and pyridoxine status in a group of pregnant Mexican women. ( Bourges, H; Halhali, A; Torres, N; Tovar, AR, 1996) |
| "The cause of reduced plasma pyridoxal-5'-phosphate (PLP) concentration and the validity of plasma PLP concentration as a vitamin B-6 status indicator during pregnancy are not well understood." | 3.68 | Vitamin B-6 status indices are lower in pregnant than in nonpregnant women but urinary excretion of 4-pyridoxic acid does not differ. ( Trumbo, PR; Wang, JW, 1993) |
| " We measured the concentrations of vitamin A, riboflavin, riboflavine-5'-monophosphate, flavine-adenine-dinucleotide, vitamin B-6, vitamin B-12, vitamin C, vitamin E, folate and ferritin in the serum of women who had previously had a child with a neural tube defect and were planning a further pregnancy." | 3.68 | Periconceptional vitamin profiles are not suitable for identifying women at risk for neural tube defects. ( Doesburg, WH; Eskes, TK; Mooij, PN; Steegers-Theunissen, RP; Thomas, CM, 1993) |
| "The cause for reduced plasma pyridoxal phosphate (PLP) concentration during pregnancy is not well understood." | 3.68 | Bioavailability of vitamin B-6 in pregnant rats. ( Trumbo, PR; Wang, JW, 1992) |
| "The author summarizes the theoretical aspects of vomiting and alleviation of the same by surveying the respective scientific communications with special regard to thiethylperazine." | 3.68 | Torecan, a review of references and clinical control examinations. ( Rádi, A, 1990) |
| "The antinausea drug combination, doxylamine/dicyclomine/pyridoxine (Debendox or Bendectin [US] ), has been withdrawn from the market because of litigation based upon charges that it causes congenital limb defects." | 3.67 | The innocent bystander. Doxylamine/dicyclomine/pyridoxine and congenital limb defects. ( Elliott, J; Forrest, J; Kricker, A; McCredie, J, 1984) |
| "Bendectin, composed of doxylamine succinate and pyridoxine HCl (1:1), is an antinauseant previously prescribed for nausea and vomiting during pregnancy." | 3.67 | Developmental toxicity evaluation of Bendectin in CD rats. ( Kimmel, CA; Marr, MC; Price, CJ; Tyl, RW, 1988) |
| "In my practice, vitamin B6 (pyridoxine) therapy (100 to 200 mg daily for 12 weeks) has proved curative for a large percentage of patients having carpal tunnel syndrome (CTS)." | 3.67 | Treatment of carpal tunnel syndrome with vitamin B6. ( Ellis, JM, 1987) |
| " Liver PLP content was also lower during pregnancy, but liver pyridoxamine 5'-phosphate (PMP), kidney PLP and PMP and muscle PLP contents did not change significantly." | 3.67 | Vitamin B-6 metabolism in the pregnant rat: effect of progesterone on the (re)distribution in maternal vitamin B-6 stores. ( Bogaards, JJ; Van den Berg, H, 1987) |
| " Methionine restriction initiated neonatally prevented mental retardation, retarded the rate of lens dislocation, and may have reduced the incidence of seizures." | 3.67 | The natural history of homocystinuria due to cystathionine beta-synthase deficiency. ( Andria, G; Boers, GH; Bromberg, IL; Cerone, R; Levy, HL; Mudd, SH; Pettigrew, KD; Pyeritz, RE; Skovby, F; Wilcken, B, 1985) |
| " The pregnancy was complicated by chronic maternal schizophrenia, severe toxaemia and maternal use of fluphenazine enanthate, dicyclomine hydrochloride, doxylamine succinate, pyridoxine hydrochloride and other drugs." | 3.66 | Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy. ( Bury, RG; Donaldson, GL, 1982) |
| "Administration of Vitamin B6 during gestation to mice on a Vitamin B6-containing diet resulted in a substantial reduction in cortisone-induced cleft palate." | 3.66 | Vitamin B6 reduces cortisone-induced cleft palate in the mouse. ( Pratt, RM; Yoneda, T, 1982) |
| "Sixteen patients, eight with acromegaly and eight with galactorrhea, were treated with pyridoxine (600 mg/day) for a three-month period." | 3.66 | Superiority of bromocriptine over pyridoxine in the treatment of patients with acromegaly or galactorrhea. ( Blum, I; Chowers, I; Kaufman, H; Sagiv, M; Segal, S; Shalit, M, 1980) |
| "Vitamins B12, B6, biotin, folate, thiamine, riboflavin, pantothenate, and nicotinate were determined in maternal and fetal blood and placental tissue of normovitaminemic and hypovitaminemic mothers who disclaimed supplemental vitamin intake during pregnancy." | 3.66 | Role of placenta in maternal-fetal vitamin transfer in humans. ( Baker, H; Deangelis, B; Feingold, S; Frank, O; Kaminetzky, HA, 1981) |
| "Thirteen women with chemical diabetes diagnosed in late pregnancy were found to excrete excessive amounts of urinary xanthurenic acid after a tryptophan load, indicative of a relative pyridoxine (vitamin B6) deficiency." | 3.66 | Pyridoxine treatment of chemical diabetes in pregnancy. ( Gillmer, MD; Mazibuko, D, 1979) |
| "The vitamin B6 nutriture was determined during pregnancy beginning at month II until term by means of determination of pyridoxal phosphate in serum of 16 healthy pregnant women." | 3.66 | Vitamin B6 nutriture during pregnancy. ( Dapunt, O; Reinken, L, 1978) |
| "The acute effect of pyridoxine (B6) on serum GH and PRL levels and its chronic effects on galactorrhea in nine subjects (group I, n=4, idiopathic galactorrhea with normal PRL levels and normal menses; Group II, n=5, galactorrhea-amenorrhea with increased PRL levels) have been studied." | 3.65 | Ineffectiveness of pyridoxine (B6) to alter secretion of growth hormone and prolactin and absence of therapeutic effects on galactorrhea-amenorrhea syndromes. ( Guyda, H; Laliberté, R; Naftolin, F; Tolis, G, 1977) |
| "Three women with the galactorrhea-amenorrhea syndrome and elevated prolactin concentrations experienced a return of regular ovulatory menses within 37-94 days after starting pyridoxine treatment (200-600 mg/day)." | 3.65 | Treatment of women with the galactorrhea-amenorrhea syndrome with pyridoxine (vitamin B6). ( McIntosh, EN, 1976) |
| "The effect of different amounts of vitamin B6 supplementation during pregnancy on maternal and fetal plasma levels of pyridoxal phosphate (PLP) at term has been studied." | 3.65 | Maternal and fetal plasma levels of pyridoxal phosphate at term: adequacy of vitamin B6 supplementation during pregnancy. ( Cleary, RE; Li, TK; Lumeng, L, 1975) |
| "An effective and safe treatment for nausea and vomiting of pregnancy (NVP) is lacking." | 3.30 | Acupuncture and Doxylamine-Pyridoxine for Nausea and Vomiting in Pregnancy : A Randomized, Controlled, 2 ( An, CM; Cao, YJ; Chen, XY; Cong, J; Cui, YM; Feng, YH; Gao, JS; Hu, YH; Li, J; Li, L; Liu, JP; Liu, L; Liu, YX; Liu, ZL; Liu, ZS; Lu, ZL; Ma, HL; Mol, BWJ; Ng, EHY; Painter, RC; Qi, X; Qin, HC; Wang, CC; Wang, Y; Wang, YX; Wu, Q; Wu, XK; Yan, Y; Yang, XM; Yu, L; Zhang, B; Zhou, LL, 2023) |
| " Study drug dosing occurred for 14 days, which is substantially longer than what has been performed in similar studies." | 2.82 | Demonstration of early efficacy results of the delayed-release combination of doxylamine-pyridoxine for the treatment of nausea and vomiting of pregnancy. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Matok, I; Mattison, DR; Miodovnik, M; Umans, JG, 2016) |
| " Pharmacokinetic parameters were calculated for each study period using standard, non-compartmental methods, and differences were assessed using ANOVA." | 2.78 | Sex differences in the pharmacokinetics and bioequivalence of the delayed-release combination of doxylamine succinate-pyridoxine hydrochloride; implications for pharmacotherapy in pregnancy. ( Gill, SK; Koren, G; Macleod, S; Vranderick, M, 2013) |
| "Oral misoprostol is an effective agent for cervical priming and labor induction in patients with pre-labor rupture of membranes at term." | 2.68 | Cervical priming with oral misoprostol in pre-labor rupture of membranes at term. ( Ho, PC; Lao, T; Ngai, SW; To, WK, 1996) |
| "81 and a dose-response relationship was noted (P = 0." | 2.66 | Maternal drug use and risk of childhood nonlymphoblastic leukemia among offspring. An epidemiologic investigation implicating marijuana (a report from the Childrens Cancer Study Group). ( Arthur, DC; Benjamin, D; Buckley, JD; Daigle, AE; Hammond, GD; Robison, LL; Wells, R, 1989) |
| "Bromocriptine was superior to pyridoxine in the parameters measured." | 2.65 | Inhibition of puerperal lactation: A comparative study of bromocriptine and pyridoxine. ( Boes, EG, 1980) |
| "Pyridoxine has been reported as having an antilactogenic effect, presumably by suppressing prolactin secretion." | 2.64 | Failure of pyridoxine to suppress raised serum prolactin levels. ( de Waal, JM; Harms, JH; Pannall, PR; Slabber, CF; Steyn, AF, 1978) |
| "Hyperemesis gravidarum is a severe form of nausea and vomiting in pregnancy affecting 0." | 2.53 | Interventions for treating hyperemesis gravidarum. ( Barton, SJ; Berghella, V; Boelig, RC; Edwards, SJ; Kelly, AJ; Saccone, G, 2016) |
| "Nausea and vomiting are common in early pregnancy." | 2.50 | The pharmacologic management of nausea and vomiting of pregnancy. ( Briggs, GG; Niebyl, JR, 2014) |
| "Of note, co-existing gastroesophageal reflux disease (GERD), Helicobacter pylori infection, and psychosocial factors may have a negative impact on the management of NVP." | 2.50 | The outpatient management and special considerations of nausea and vomiting in pregnancy. ( Clark, SM; Dutta, E; Hankins, GD, 2014) |
| "Nausea and vomiting affects a large proportion of women in early pregnancy, yet because it is a physiological symptom it is often dismissed by health professionals, leaving women to find their own coping mechanisms." | 2.41 | Nausea and vomiting in pregnancy: safety and efficacy of self-administered complementary therapies. ( Tiran, D, 2002) |
| "Early pregnancy is characterized by nausea and vomiting which are the most frequent symptoms and the main reason for consulting the physician." | 2.41 | [Evaluation and treatment of hyperemesis gravidarum]. ( Accorsi, P; Aguzzoli, L; Carossino, E; Crotti, M; Gargano, G; Masellis, G, 2001) |
| "Subclinical riboflavin deficiency impairs psychomotor function and vitamin B2 requirement may be enhanced during increased physical activity." | 2.40 | Riboflavin metabolism--relevance to human nutrition. ( Lakshmi, AV, 1998) |
| " The following precautions are suggested to minimize the risks of potentially harmful pharmacons: 1) all unnecessary medications should be avoided by nrusing mothers; 2) if medication is necessary during lactation, drug dosage should be controlled and the infant should be monitored for adverse symptoms; 3) drugs should be administered shortly after breastfeeding and the interval prolonged before the next feeding; and 4) if the infant must be fed soon after a potentially harmful drug has been taken by the mother, bottle feeding is recommended." | 2.37 | Maternal drug use: evaluation of risks to breast-fed infants. ( Groziak, SM; Kirksey, A, 1984) |
| "Diet has been associated with cancer, heart disease, diabetes, stroke and hypertension, arteriosclerosis, and cirrhosis of the liver." | 2.37 | Implications of nutritional status on human biochemistry, physiology, and health. ( Sauberlich, HE, 1984) |
| " Pyridoxine is considered safe for use during pregnancy, but its efficacy in treating nausea and vomiting has not been determined." | 2.37 | Safety and efficacy of antiemetics used to treat nausea and vomiting in pregnancy. ( Leathem, AM, 1986) |
| "A literature review was conducted on adverse effects associated with administration of high oral doses of pyridoxine (vitamin B6) to animals and man." | 2.37 | Safety of pyridoxine--a review of human and animal studies. ( Bendich, A; Cohen, M, 1986) |
| " There are different pharmaceutical dosage forms in the European market." | 1.72 | Comparative dissolution profiles of two anti-emetic delayed release dosage forms of doxylamine and pyridoxine: Xonvea® tablets vs. Cariban® capsules. ( Alcocer, C; Gergic, E; Hoarau, D; Iraola, M; Perez de la Cruz, MA; Regidor, PA; Rom, E, 2022) |
| " Restricted cubic splines were plotted to evaluate the dose-response relationship between dietary OCM-related nutrient intake and the risk of PE." | 1.72 | One-carbon metabolism-related nutrients intake is associated with lower risk of preeclampsia in pregnant women: a matched case-control study. ( Bo, Y; Cao, Y; Dou, W; Duan, D; Fu, W; Liu, Y; Lyu, Q; Ma, S; Zeng, F; Zhao, X, 2022) |
| " Thus, in France, as in other countries, vitamin B6 could be integrated into the therapeutic arsenal of mild to moderate nausea and vomiting during pregnancy according to the following dosage schedule: oral intake of 10mg four times a day of a compounded preparation of vitamin B6, alone or in combination with doxylamine." | 1.56 | [Interest of vitamin b6 for treatment of nausea and/or vomiting during pregnancy]. ( Pecriaux, C, 2020) |
| "Sideroblastic anemias are a heterogeneous group of disorders characterized by anemia of varying severity and the presence of ringed sideroblasts in bone marrow." | 1.42 | Microcytic anemia in a pregnant woman: beyond iron deficiency. ( Fernández-Jiménez, MC; Morán-Jiménez, MJ; Moreno-Carralero, MI; Murga-Fernández, MJ; Rollón, N, 2015) |
| " On the other hand, co-administration of 10mg/kg pyridoxine, at ED 9 and 10, significantly increased the frequencies of anomalies, even in the moderate dosage (500 mg/kg) group." | 1.36 | Pyridoxine might not have a preventive effect on the retinyl palmitate-induced viscerocranial anomalies. ( Ay, H; Ulupinar, E; Unal, N, 2010) |
| "Epileptic seizures due to pyridoxine deficiency, although rare, are known to occur." | 1.35 | Epileptic status refractory to conventional treatment caused by vitamin B6 deficiency. ( Barber, M; Cortés-Cros, E; Figueras, T; García-Hernández, JA; Santana, A; Valle-Morales, L, 2009) |
| "One pregnancy was terminated and two pregnancies resulted in first-trimester spontaneous abortions." | 1.31 | Reproductive fitness in maternal homocystinuria due to cystathionine beta-synthase deficiency. ( Bao, L; Gilfix, BM; Greenberg, CR; Kraus, JP; Kurczynski, TW; Levy, HL; MacGregor, D; Prasad, C; Roeder, ER; Rosengren, S; Schwartz, RS; Shih, VE; Vargas, JE; Waisbren, SE, 2002) |
| " While the liver and total body wet weights as well as the haematological parameters (red blood cells, haemoglobin concentration, hematocrit, middle corpuscular cell volume, middle corpuscular haemoglobin, middle corpuscular haemoglobin concentration) did not differ within the experimental groups, the present data clearly show that in blood, liver and total body of the offspring exists a slight dose-response relationship between the maternal dietary vitamin B6 supplementation and the vitamin B6 concentration." | 1.31 | Effects of vitamin B6 supplementation in rats during lactation on vitamin B6 concentration and transaminase activities in the offspring. ( Benedikt, J; Kettler, SI; Kirchgessner, M; Roth-Maier, DA, 2000) |
| "Case infants (n = 998) had nonsyndromic congenital heart defects and control infants (n = 3,029) had no congenital defects." | 1.30 | Nausea during pregnancy and congenital heart defects: a population-based case-control study. ( Boneva, RS; Botto, L; Erickson, JD; Moore, CA; Wong, LY, 1999) |
| "Transferrin in turn was inversely correlated with haemoglobin." | 1.29 | Vitamin B1, B2 and B6 during the course of pregnancy of rural and urban women in northeast Thailand. ( Intarakhao, C; Lumbiganon, P; Mahaweeravat, U; Phonrat, B; Pongpaew, P; Rojsathaporn, K; Saowakontha, S; Schelp, FP; Supawan, V; Vudhivai, N, 1995) |
| "Wilson's Disease is an inherited disorder of copper metabolism." | 1.29 | [Wilson's disease: a review apropos of a clinical experience in 16 patients]. ( Alarcón, T; Brinck, P; González, M; Miranda, M; Roessler, JL; Troncoso Sch, M; Villagra, R, 1995) |
| "Pyridoxine treatment had no clinical effect but led to a fall in CSF L-dopa and 3-methoxytyrosine and a rise in S-adenosylmethionine." | 1.28 | Aromatic L-amino acid decarboxylase deficiency: clinical features, diagnosis, and treatment of a new inborn error of neurotransmitter amine synthesis. ( Clayton, PT; Hyland, K; Rodeck, C; Surtees, RA, 1992) |
| "Sideroblastic anemias are a diverse group of hypoproliferative anemias characterized by defective iron use within erythropoietic cells and a defect in heme biosynthesis." | 1.28 | Successive pregnancies complicated by idiopathic sideroblastic anemia. ( Barton, JR; Shaver, DC; Sibai, BM, 1992) |
| "Eleven days after a caesarean section cerebral infarction was diagnosed." | 1.28 | Cerebral infarction after caesarean section due to heterozygosity for homocystinuria; a case report. ( Boers, GH; de Wit, PH; Minkhorst, AG; van Dongen, PW, 1991) |
| "Two hundred cases of verified brain tumors occurring in patients under 15 years of age were studied in relation to possible etiologic, genetic, and environmental risk factors." | 1.28 | Potential risk factors for brain tumors in children. An analysis of 200 cases. ( Giuffrè, R; Liccardo, G; Pastore, FS; Spallone, A; Vagnozzi, R, 1990) |
| " Two pharmacokinetic experiments were performed in each animal, one on the first day of treatment and one on the last day of treatment." | 1.28 | Pharmacokinetics of doxylamine given as Bendectin in the pregnant monkey and baboon. ( Denton, R; Hendrickx, AG; Holder, CL; Prahalada, S; Rowland, JM; Slikker, W; Young, JF, 1989) |
| "Thiamine deficiencies were found in 15% of placentas, 59% of maternal RBC and 41% of cord RBC." | 1.27 | Vitamin cofactor saturation indices for riboflavin, thiamine, and pyridoxine in placental tissue of Kenyan women. ( Clark, V; Neumann, C; Ramsay, VP; Swendseid, ME, 1983) |
| ""Perinatal" hypophosphatasia is the most severe form of this inborn error of metabolism, which is characterized by deficient activity of the tissue-nonspecific (liver/bone/kidney) isoenzyme of alkaline phosphatase (ALP) (TNSALP)." | 1.27 | Perinatal hypophosphatasia: tissue levels of vitamin B6 are unremarkable despite markedly increased circulating concentrations of pyridoxal-5'-phosphate. Evidence for an ectoenzyme role for tissue-nonspecific alkaline phosphatase. ( Coburn, SP; Cole, FS; Fedde, KN; Mahuren, JD; McCabe, ER; Whyte, MP, 1988) |
| " There was no correlation between dosage and the number of prenatal deaths." | 1.27 | Evaluation of bendectin embryotoxicity in nonhuman primates: II. Double-blind study in term cynomolgus monkeys. ( Booher, S; Cukierski, M; Hendrickx, AG; Janos, G; Nyland, T; Prahalada, S, 1985) |
| "Untreated Wilson's disease usually causes infertility or abortion, as a result of increased intrauterine copper level." | 1.27 | [Teratogenic risk during treatment of Wilson disease]. ( Mathieu, M; Piussan, C, 1985) |
| " No dose-response relationship was evident." | 1.27 | Inter-Regional Epidemiological Study of Childhood Cancer (IRESCC): childhood cancer and the consumption of debendox and related drugs in pregnancy. ( Birch, JM; Cartwright, RA; Hartley, AL; Hopton, PA; Johnston, HE; Mann, JR; McKinney, PA; Stiller, CA; Waterhouse, JA, 1985) |
| "Whether the severity of vitamin B6 deficiency would precipitate clinical signs like oral lesions is not yet known." | 1.26 | Biochemical assessment of vitamin B6 nutritional status in pregnant women with orolingual manifestations. ( Bapurao, S; Raman, L; Tulpule, PG, 1982) |
| " Long-term use of OCA (greater than 30 months) resulted in low levels of vitamin B6 in maternal serum at 5 months gestation and at delivery and in milk compared with values for short-term (1 to 30 months) and nonusers of OCA." | 1.26 | Vitamin B6 nutriture during pregnancy and lactation. II. The effect of long-term use of oral contraceptives. ( Kirksey, A; Roepke, JL, 1979) |
| "Pyridoxine treatment did not inhibit milk secretion in 14 puerperal women." | 1.26 | The influence of pyridoxine on prolactin secretion and milk production in women. ( Canales, ES; Mason, M; Molina, M; Soria, J; Zárate, A, 1976) |
| "The last chapter deals with the vitamin B6 deficiency syndromes in infancy and childhood." | 1.25 | [Experimental studies concerning the metabolism, the nutriture, and the requirement for vitamin B6 in childhood (author's transl)]. ( Reinken, L, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 430 (67.93) | 18.7374 |
| 1990's | 88 (13.90) | 18.2507 |
| 2000's | 46 (7.27) | 29.6817 |
| 2010's | 55 (8.69) | 24.3611 |
| 2020's | 14 (2.21) | 2.80 |
| Authors | Studies |
|---|---|
| Husebye, ESN | 1 |
| Riedel, B | 1 |
| Bjørke-Monsen, AL | 2 |
| Spigset, O | 1 |
| Daltveit, AK | 1 |
| Gilhus, NE | 1 |
| Bjørk, MH | 1 |
| Saad, AS | 1 |
| Draz, ME | 1 |
| Naguib, IA | 1 |
| Zaazaa, HE | 1 |
| Lashien, AS | 1 |
| Abdallah, FF | 1 |
| Alcocer, C | 1 |
| Iraola, M | 1 |
| Rom, E | 1 |
| Hoarau, D | 1 |
| Gergic, E | 1 |
| Perez de la Cruz, MA | 1 |
| Regidor, PA | 1 |
| Schrager, NL | 1 |
| Parker, SE | 1 |
| Werler, MM | 1 |
| Ali, MA | 1 |
| Hafez, HA | 1 |
| Kamel, MA | 1 |
| Ghamry, HI | 1 |
| Shukry, M | 1 |
| Farag, MA | 1 |
| Ma, S | 1 |
| Bo, Y | 1 |
| Zhao, X | 1 |
| Cao, Y | 1 |
| Duan, D | 1 |
| Dou, W | 1 |
| Fu, W | 1 |
| Zeng, F | 1 |
| Lyu, Q | 1 |
| Liu, Y | 1 |
| Jayawardena, R | 1 |
| Majeed, S | 1 |
| Sooriyaarachchi, P | 1 |
| Abeywarne, U | 1 |
| Ranaweera, P | 1 |
| Deepa, R | 1 |
| Mandal, S | 1 |
| Van Schayck, OCP | 1 |
| Babu, GR | 1 |
| Saz-Leal, P | 1 |
| Zamorano-Domínguez, L | 1 |
| Frías, J | 1 |
| Guerra, P | 1 |
| Saura-Valls, M | 1 |
| Roca-Juanes, R | 1 |
| Nebot-Troyano, J | 1 |
| García-Aguilar, E | 1 |
| Vilchez, T | 1 |
| Urso, K | 1 |
| Wu, XK | 1 |
| Gao, JS | 1 |
| Ma, HL | 1 |
| Wang, Y | 2 |
| Zhang, B | 1 |
| Liu, ZL | 1 |
| Li, J | 1 |
| Cong, J | 1 |
| Qin, HC | 1 |
| Yang, XM | 1 |
| Wu, Q | 1 |
| Chen, XY | 1 |
| Lu, ZL | 1 |
| Feng, YH | 1 |
| Qi, X | 1 |
| Wang, YX | 1 |
| Yu, L | 1 |
| Cui, YM | 1 |
| An, CM | 1 |
| Zhou, LL | 1 |
| Hu, YH | 1 |
| Li, L | 1 |
| Cao, YJ | 1 |
| Yan, Y | 1 |
| Liu, L | 1 |
| Liu, YX | 1 |
| Liu, ZS | 1 |
| Painter, RC | 2 |
| Ng, EHY | 1 |
| Liu, JP | 1 |
| Mol, BWJ | 1 |
| Wang, CC | 1 |
| Varsi, K | 1 |
| Sakkestad, ST | 1 |
| Ulvik, A | 1 |
| Ebbing, C | 1 |
| Ueland, PM | 1 |
| Fejzo, MS | 1 |
| Trovik, J | 1 |
| Grooten, IJ | 1 |
| Sridharan, K | 1 |
| Roseboom, TJ | 1 |
| Vikanes, Å | 1 |
| Mullin, PM | 1 |
| MacDuffie, KE | 1 |
| Kleinhans, NM | 1 |
| Stout, K | 1 |
| Wilfond, BS | 1 |
| Pecriaux, C | 1 |
| Biffi, A | 1 |
| Rea, F | 1 |
| Locatelli, A | 1 |
| Cetin, I | 1 |
| Filippelli, A | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prevalence and Burden of Nausea and Vomiting in Pregnant Women in Switzerland: Survey Purity 2022[NCT06055192] | 200 participants (Anticipated) | Observational | 2023-09-30 | Not yet recruiting | |||
| A Double-Blind, Multicenter, Randomized, Placebo-Controlled Trial Of The Efficacy Of Diclectin® For Nausea And Vomiting Of Pregnancy[NCT00614445] | Phase 3 | 280 participants (Actual) | Interventional | 2008-01-31 | Completed | ||
| Is Zofran Superior to Pyridoxine at Reducing Nausea and Vomiting in Pregnancy[NCT01668069] | 36 participants (Actual) | Interventional | 2012-10-31 | Completed | |||
| The Effect of Adjuvant Hypnosis Added to Conventional Therapy on Nausea and Vomiting in Hyperemesis Gravidarum: A Prospective Randomized Study[NCT04828967] | 41 participants (Actual) | Interventional | 2017-01-01 | Completed | |||
| A Study of the Pharmacology of 17-Hydroxyprogesterone Caproate in Pregnancy[NCT00409825] | Phase 2 | 61 participants (Actual) | Interventional | 2006-03-31 | Completed | ||
| SIngle-Stage, Open-Label, Safety and Efficacy Study of Adeno-Associated Virus Encoding Human Aromatic L-Amino Acid Decarboxylase by Magnetic Resonance MR-guided Infusion Into Midbrain in Pediatric Patients With AADC Deficiency[NCT02852213] | Phase 1 | 31 participants (Anticipated) | Interventional | 2016-07-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The objective of this double-blind, randomized, placebo-controlled study was to assess the efficacy, safety, and tolerability of oral Diclectin® in the treatment of nausea and vomiting of pregnancy (NVP) as measured by the Pregnancy Unique-Quantification of Emesis (PUQE) overall score of symptoms from baseline (Day 1) to end of study visit (Day 15). The PUQE score measured hours of nausea, number of times vomiting, and number of times retching for a TOTAL overall score of symptoms on a scale rated from 3 (no symptoms) to 15 (most severe). (NCT00614445)
Timeframe: Baseline (Day 1) to End of Study Visit Day 15 (± 1 day)
| Intervention | PUQE Score (Mean) |
|---|---|
| Diclectin® | -4.8 |
| Placebo | -3.9 |
"Change in the area under the concentration vs. time curve in the second and third trimesters of pregnancy.~We compared AUC at each PK study visit. Measurements were obtained at 0, 1, 2, 3, 4, 5, 6, 7 days." (NCT00409825)
Timeframe: Second and third trimesters of pregnancy
| Intervention | ng/ML/day (Mean) | |
|---|---|---|
| AUC -1 | AUC - 2 | |
| Part 1 | 115 | 136 |
73 reviews available for pyridoxine and Pregnancy
| Article | Year |
|---|---|
Dietary Vitamin B Complex: Orchestration in Human Nutrition throughout Life with Sex Differences.
Topics: Adolescent; Adult; Aged; Child; Female; Folic Acid; Humans; Male; Niacin; Pantothenic Acid; Pregnanc | 2022 |
The effects of pyridoxine (vitamin B6) supplementation in nausea and vomiting during pregnancy: a systematic review and meta-analysis.
Topics: Antiemetics; Dietary Supplements; Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyrido | 2023 |
Nausea and vomiting of pregnancy and hyperemesis gravidarum.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Growth Differentiation Factor 15; H | 2019 |
Misleading meta-analyses of observational studies may generate unjustified alarms: The case of medications for nausea and vomiting in pregnancy.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 2021 |
Doxylamine/pyridoxine for nausea and vomiting in pregnancy.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Practice Guidelines | 2019 |
The pharmacologic management of nausea and vomiting of pregnancy.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Histamine H1 Antagonists; Humans; N | 2014 |
The delayed-release combination of doxylamine and pyridoxine (Diclegis®/Diclectin ®) for the treatment of nausea and vomiting of pregnancy.
Topics: Antiemetics; Delayed-Action Preparations; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 2014 |
Nausea and vomiting in early pregnancy.
Topics: Acupressure; Acupuncture Therapy; Adrenal Cortex Hormones; Antiemetics; Female; Humans; Nausea; Preg | 2014 |
The outpatient management and special considerations of nausea and vomiting in pregnancy.
Topics: Ambulatory Care; Antiemetics; Diet Therapy; Doxylamine; Female; Fluid Therapy; Gastroesophageal Refl | 2014 |
Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes.
Topics: Birth Weight; Dental Caries; Dietary Supplements; Eclampsia; Female; Humans; Infant, Newborn; Labor, | 2015 |
Interventions for treating hyperemesis gravidarum.
Topics: Acupuncture Therapy; Adrenal Cortex Hormones; Antiemetics; Female; Humans; Hydrocortisone; Hyperemes | 2016 |
Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review.
Topics: Acupuncture; Adrenal Cortex Hormones; Antiemetics; Doxylamine; Female; Histamine Antagonists; Humans | 2016 |
Clinical practice. Nausea and vomiting in pregnancy.
Topics: Adult; Chorionic Gonadotropin; Complementary Therapies; Diagnosis, Differential; Dicyclomine; Doxyla | 2010 |
Contemporary approaches to hyperemesis during pregnancy.
Topics: Adrenal Cortex Hormones; Antiemetics; Diet; Doxylamine; Female; Humans; Hyperemesis Gravidarum; Obst | 2011 |
Nausea and vomiting in pregnancy: safety and efficacy of self-administered complementary therapies.
Topics: Acupressure; Acupuncture Therapy; Attitude to Health; Complementary Therapies; Female; Humans; Mater | 2002 |
Nausea and vomiting in early pregnancy.
Topics: Acupressure; Acupuncture Therapy; Adrenal Cortex Hormones; Female; Histamine H1 Antagonists; Humans; | 2003 |
Pyridoxine (vitamin B6) supplementation in pregnancy.
Topics: Dietary Supplements; Female; Humans; Pregnancy; Pregnancy Outcome; Pyridoxine; Randomized Controlled | 2006 |
Maternal drug use: evaluation of risks to breast-fed infants.
Topics: Analgesics; Anti-Bacterial Agents; Breast; Breast Feeding; Central Nervous System Stimulants; Contra | 1984 |
Teratogen update: bendectin.
Topics: Abnormalities, Drug-Induced; Animals; Dicyclomine; Doxylamine; Drug Combinations; Drug Utilization; | 1983 |
Effects of drugs and chemicals on the fetus and newborn (1).
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Behavior; Caffeine; Dicyclomine; Doxylamine; Drug | 1984 |
Clinical chemistry of vitamin B6.
Topics: Animals; Biological Assay; Biological Availability; Biological Transport; Chemical Phenomena; Chemis | 1983 |
Drug exposure during pregnancy: some epidemiologic considerations.
Topics: Abnormalities, Drug-Induced; Benzodiazepines; Caffeine; Dicyclomine; Doxylamine; Drug Combinations; | 1983 |
Implications of nutritional status on human biochemistry, physiology, and health.
Topics: Alcoholism; Anemia, Hypochromic; Animals; Ascorbic Acid; Avitaminosis; Climate; Dietary Fats; Female | 1984 |
Progress in experimental phenylketonuria: a critical review.
Topics: Abnormalities, Multiple; Animals; Disease Models, Animal; Energy Metabolism; Female; Fenclonine; Glu | 1981 |
[Clinical significance of amino acid transformations as affected by pyridoxal phosphate enzymes].
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Amino Acids, Essential; Animals; Arteriosclerosis | 1982 |
Safety of drug therapy for nausea and vomiting of pregnancy.
Topics: Abnormalities, Drug-Induced; Antiemetics; Child; Dicyclomine; Doxylamine; Drug Combinations; Female; | 1980 |
Red cell enzyme tests of vitamin status: do marginal deficiencies have any physiological significance?
Topics: Adult; Aged; Alanine Transaminase; Animals; Aspartate Aminotransferases; Child; Clinical Enzyme Test | 1981 |
Bendectin and birth defects: I. A meta-analysis of the epidemiologic studies.
Topics: Abnormalities, Drug-Induced; Antiemetics; Case-Control Studies; Cohort Studies; Dicyclomine; Doxylam | 1994 |
Vitamin B6 and cognitive development: recent research findings from human and animal studies.
Topics: Animals; Animals, Newborn; Brain; Cognition; Female; Humans; Infant; Maternal-Fetal Exchange; Pregna | 1993 |
Modeling vitamin B6 metabolism.
Topics: Animals; Erythrocytes; Female; Humans; Kinetics; Models, Biological; Nutritional Requirements; Pregn | 1996 |
[The importance of vitamin B 6 for development of the infant. Human medical and animal experiment studies].
Topics: Animals; Central Nervous System; Central Nervous System Diseases; Dopamine; Female; gamma-Aminobutyr | 1996 |
Alternative therapies for nausea and vomiting of pregnancy.
Topics: Acupressure; Complementary Therapies; Female; Humans; Nausea; Phytotherapy; Pregnancy; Pyridoxine; V | 1998 |
[Vitamins : B1, B6, B12. Consequences of a deficiency, of excessive vitamins and value of systematic supplementation].
Topics: Dietary Supplements; Female; Humans; Nutritional Requirements; Pregnancy; Pregnancy Complications; P | 1997 |
Drugs in pregnancy.
Topics: Abnormalities, Drug-Induced; Animals; Counseling; Dicyclomine; Doxylamine; Drug Combinations; Drug E | 1998 |
Riboflavin metabolism--relevance to human nutrition.
Topics: Diabetes Mellitus; Female; Humans; Neoplasms; Nutrition Disorders; Pregnancy; Pyridoxine; Respirator | 1998 |
Pyridoxine (vitamin B6) supplementation in pregnancy.
Topics: Dietary Supplements; Female; Humans; Pregnancy; Pyridoxine | 2000 |
Critical appraisal of drug therapy for nausea and vomiting of pregnancy: II. Efficacy and safety of diclectin (doxylamine-B6).
Topics: Antiemetics; Doxylamine; Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Ran | 2000 |
Alternative therapies of morning sickness.
Topics: Acupressure; Antiemetics; Complementary Therapies; Dicyclomine; Doxylamine; Drug Combinations; Femal | 2001 |
[Evaluation and treatment of hyperemesis gravidarum].
Topics: Administration, Oral; Adult; Antiemetics; Birth Weight; Chlorpromazine; Diagnosis, Differential; Fem | 2001 |
Medical, social, and legal implications of treating nausea and vomiting of pregnancy.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 2002 |
Are we failing women? Advice for nausea and vomiting in pregnancy.
Topics: Acupressure; Causality; Female; Humans; Maternal-Child Nursing; Nausea; Nurse Midwives; Nurse's Role | 2001 |
Vitamin B6 deficiency and immune responses.
Topics: Animals; Antibody Formation; Antimetabolites; BCG Vaccine; Cell Count; Female; Fetus; Humans; Immuni | 1976 |
The interactions between vitamin B6 and hormones.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Biogenic Amines; Brain; Contraceptives, Oral, | 1978 |
Nutritional influences during pregnancy.
Topics: Ascorbic Acid; Birth Weight; Body Weight; Calcium, Dietary; Dietary Proteins; Energy Metabolism; Fem | 1977 |
Vitamin toxicity.
Topics: Adult; Animals; Ascorbic Acid; Cricetinae; Female; Folic Acid; Goats; Guinea Pigs; Humans; Nicotinic | 1977 |
Requirement of vitamin B6 during pregnancy.
Topics: Contraceptives, Oral; Female; Fetal Blood; Humans; Mouth Diseases; Nutritional Requirements; Pregnan | 1976 |
Effects of oral contraceptives on vitamin metabolism.
Topics: Ascorbic Acid; Blood Platelets; Contraceptives, Oral; Depression; Female; Folic Acid; Humans; Leukoc | 1976 |
Carbohydrate metabolism in male infertility and female fertility-control patients.
Topics: Candidiasis, Vulvovaginal; Carbohydrate Metabolism; Contraceptives, Oral; Diabetes Complications; Di | 1976 |
Reviews of the progress of Dairy Science. Water-soluble vitamins in milk and milk products.
Topics: Animal Nutritional Physiological Phenomena; Animals; Ascorbic Acid; Cattle; Dairy Products; Female; | 1975 |
Drugs that affect the breast and lactation.
Topics: Androgens; Apomorphine; Barbiturates; Breast; Breast Neoplasms; Bromocriptine; Contraceptives, Oral, | 1975 |
Vitamins and minerals in pregnancy.
Topics: Animals; Ascorbic Acid; Calcium, Dietary; Female; Humans; Hypocalcemia; Infant, Newborn; Infant, New | 1975 |
Vitamin passage across the placenta.
Topics: Ascorbic Acid; Biological Transport; Biological Transport, Active; Diffusion; Female; Fetus; Humans; | 1975 |
Regulation of immune responses by vitamin B6.
Topics: Animals; Antibody Formation; Complement System Proteins; Female; Humans; Immunity; Immunity, Cellula | 1990 |
Drug therapy in pregnancy: the lessons of diethylstilbestrol, thalidomide, and bendectin.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Diethylstilbestrol; Doxylamine; Drug Combinat | 1990 |
Vitamin B6 requirements and recommendations.
Topics: Adolescent; Aged; Animals; Female; Humans; Infant; Nutritional Requirements; Nutritional Status; Pre | 1989 |
Vitamin B6 and glucocorticoid action.
Topics: Animals; Borohydrides; Caseins; Cell Line; Cell Nucleus; Centrifugation, Density Gradient; Chemical | 1986 |
Safety and efficacy of antiemetics used to treat nausea and vomiting in pregnancy.
Topics: Antiemetics; Antipsychotic Agents; Dicyclomine; Diphenhydramine; Doxylamine; Drug Combinations; Fema | 1986 |
Diseases associated with defects in vitamin B6 metabolism or utilization.
Topics: Alkaline Phosphatase; Arteriosclerosis; Celiac Disease; Female; Hematologic Diseases; Humans; Kidney | 1987 |
Nutrient utilization during pregnancy.
Topics: Body Weight; Calcium; Dietary Proteins; Energy Intake; Energy Metabolism; Female; Folic Acid; Humans | 1987 |
Safety of pyridoxine--a review of human and animal studies.
Topics: Abnormalities, Drug-Induced; Animals; Dose-Response Relationship, Drug; Female; Humans; Nervous Syst | 1986 |
The creation of therapeutic orphans--or, what have we learnt from the Debendox fiasco?
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Australia; Clinical Trials as Topic; Cyclohexanec | 1985 |
Dietary treatment of inborn errors of metabolism.
Topics: Ammonia; Carbohydrate Metabolism, Inborn Errors; Diet Therapy; Female; Fructose; Galactosemias; Glyc | 1970 |
Testing the functional capacity of the tryptophan-niacin pathway in man by analysis of urinary metabolites.
Topics: Adult; Amides; Amines; Chromatography, Ion Exchange; Equipment and Supplies; Female; Hormones; Human | 1965 |
Excretion of tryptophan metabolites as affected by pregnancy, contraceptive steroids, and steroid hormones.
Topics: Androsterone; Animals; Contraceptives, Oral; Enzyme Induction; Estradiol; Female; Humans; Hydrocorti | 1971 |
[Scope and effect of vitamin B6 in newborn infants and children].
Topics: Amino Acids; Anemia, Hypochromic; Aspartate Aminotransferases; Brain; Coenzymes; Drug Antagonism; Fe | 1974 |
Metabolism of vitamin B 6 in the pregnant rat.
Topics: Animals; Biological Transport; Carbon Isotopes; Chromatography, Ion Exchange; Diet; Female; Fetus; M | 1972 |
Biochemical assessment of the nutritional status of vitamin B 6 in the human.
Topics: Adolescent; Adult; Alanine Transaminase; Amino Acids; Aspartate Aminotransferases; Carboxylic Acids; | 1972 |
Vitamin B 6 deficiency and brain lipids in the suckling rat.
Topics: Animals; Brain; Cholesterol; Female; Glycolipids; Lipid Metabolism; Liver; Myelin Sheath; Phospholip | 1972 |
[Oral contraceptives and vitamins].
Topics: Animals; Ascorbic Acid; Blood Glucose; Contraceptives, Oral; Depression; Depression, Chemical; Estro | 1974 |
Methionine metabolism in man: development and deficiencies.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Cystathionine; Female; Fetus; Heterozygote; Homocystinu | 1974 |
Chloroquine.
Topics: Abnormalities, Drug-Induced; Animals; Ascorbic Acid; Child; Chloroquine; Enzymes; Eye Diseases; Fema | 1967 |
[Mechanism of the formation and accumulation of blastomogenic (leukozogenic) metabolites of tryptophan].
Topics: Animals; Carcinogens; Drosophila; Female; Humans; Indican; Indoleacetic Acids; Indoles; Leukemia; Le | 1969 |
Developments leading to the metabolic role of vitamin B 6.
Topics: Acrodynia; Adult; Aged; Aging; Amines; Animals; Arteriosclerosis; Aspartate Aminotransferases; Biolo | 1971 |
59 trials available for pyridoxine and Pregnancy
| Article | Year |
|---|---|
Acupuncture and Doxylamine-Pyridoxine for Nausea and Vomiting in Pregnancy : A Randomized, Controlled, 2
Topics: Acupuncture Therapy; Antiemetics; Child; Doxylamine; Female; Humans; Nausea; Pregnancy; Pregnancy Co | 2023 |
Efficacy of Gingocap as compared to pyridoxine in the treatment of nausea and vomiting during pregnancy.
Topics: Adult; Aged; Antiemetics; Female; Humans; Middle Aged; Morning Sickness; Pakistan; Phytotherapy; Pla | 2016 |
A comparison between the effects of ginger, pyridoxine (vitamin B6) and placebo for the treatment of the first trimester nausea and vomiting of pregnancy (NVP).
Topics: Adult; Female; Humans; Hyperemesis Gravidarum; Phytotherapy; Plant Preparations; Pregnancy; Pregnanc | 2018 |
Doxylamine-pyridoxine for nausea and vomiting of pregnancy randomized placebo controlled trial: Prespecified analyses and reanalysis.
Topics: Doxylamine; Drug Therapy, Combination; Female; Humans; Morning Sickness; Placebos; Pregnancy; Pyrido | 2018 |
Comparing the pharmacokinetics of doxylamine/pyridoxine delayed-release combination in nonpregnant women of reproductive age and women in the first trimester of pregnancy.
Topics: Adolescent; Adult; Antiemetics; Delayed-Action Preparations; Dicyclomine; Double-Blind Method; Doxyl | 2013 |
Sex differences in the pharmacokinetics and bioequivalence of the delayed-release combination of doxylamine succinate-pyridoxine hydrochloride; implications for pharmacotherapy in pregnancy.
Topics: Adult; Antiemetics; Delayed-Action Preparations; Dicyclomine; Doxylamine; Drug Combinations; Female; | 2013 |
Studying the antiemetic effect of vitamin B6 for morning sickness: pyridoxine and pyridoxal are prodrugs.
Topics: Antiemetics; Delayed-Action Preparations; Dicyclomine; Double-Blind Method; Doxylamine; Drug Combina | 2014 |
Ondansetron compared with doxylamine and pyridoxine for treatment of nausea in pregnancy: a randomized controlled trial.
Topics: Adult; Antiemetics; Double-Blind Method; Doxylamine; Drug Therapy, Combination; Female; Follow-Up St | 2014 |
Comparing pyridoxine and doxylamine succinate-pyridoxine HCl for nausea and vomiting of pregnancy: A matched, controlled cohort study.
Topics: Adult; Antiemetics; Cohort Studies; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Morn | 2015 |
Maternal safety of the delayed-release doxylamine and pyridoxine combination for nausea and vomiting of pregnancy; a randomized placebo controlled trial.
Topics: Adult; Antiemetics; Delayed-Action Preparations; Dicyclomine; Double-Blind Method; Doxylamine; Drug | 2015 |
A RCT of psychotherapy in women with nausea and vomiting of pregnancy.
Topics: Adolescent; Adult; Cognitive Behavioral Therapy; Combined Modality Therapy; Female; Humans; Mindfuln | 2015 |
Effectiveness of doxylamine-pyridoxine for morning sickness.
Topics: Delayed-Action Preparations; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Morning Sic | 2016 |
Demonstration of early efficacy results of the delayed-release combination of doxylamine-pyridoxine for the treatment of nausea and vomiting of pregnancy.
Topics: Antiemetics; Delayed-Action Preparations; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 2016 |
8-Way Randomized Controlled Trial of Doxylamine, Pyridoxine and Dicyclomine for Nausea and Vomiting during Pregnancy: Restoration of Unpublished Information.
Topics: Cooperative Behavior; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Physicians | 2017 |
A placebo-controlled trial of oral pyridoxine in hyperemesis gravidarum.
Topics: Adult; Antiemetics; Drug Therapy, Combination; Female; Humans; Hyperemesis Gravidarum; Metoclopramid | 2009 |
Pharmacokinetic comparison of a delayed-release combination of doxylamine succinate and pyridoxine hydrocholoride (Diclectin) and oral solutions of these drugs in healthy women of childbearing age.
Topics: Adult; Antiemetics; Area Under Curve; Biological Availability; Cross-Over Studies; Delayed-Action Pr | 2009 |
Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
Topics: Adult; Delayed-Action Preparations; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Meth | 2010 |
Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
Topics: Adult; Delayed-Action Preparations; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Meth | 2010 |
Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
Topics: Adult; Delayed-Action Preparations; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Meth | 2010 |
Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
Topics: Adult; Delayed-Action Preparations; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Meth | 2010 |
Vitamin B₆ supplementation in pregnant women with nausea and vomiting.
Topics: Adult; Biomarkers; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; M | 2012 |
Determinants of adherence to delayed-release doxylamine and pyridoxine in patients with nausea and vomiting of pregnancy.
Topics: Adult; Antiemetics; Cohort Studies; Delayed-Action Preparations; Dicyclomine; Double-Blind Method; D | 2012 |
Comparison of three outpatient regimens in the management of nausea and vomiting in pregnancy.
Topics: Adult; Antiemetics; Drug Therapy, Combination; Female; Humans; Hyperemesis Gravidarum; Metoclopramid | 2003 |
Is lack of morning sickness teratogenic? A prospective controlled study.
Topics: Adult; Antiemetics; Congenital Abnormalities; Doxylamine; Female; Genetic Counseling; Humans; Matern | 2004 |
Pre-emptive therapy for severe nausea and vomiting of pregnancy and hyperemesis gravidarum.
Topics: Adult; Antiemetics; Dicyclomine; Doxylamine; Drug Administration Schedule; Drug Combinations; Female | 2004 |
Vitamin B supplementation for leg cramps during pregnancy.
Topics: Aspartic Acid; Calcium Carbonate; Drug Therapy, Combination; Female; Humans; Leg; Muscle Cramp; Preg | 2006 |
Possible prevention of neural-tube defects by periconceptional vitamin supplementation.
Topics: Abortion, Spontaneous; Ascorbic Acid; Avitaminosis; Clinical Trials as Topic; Drug Combinations; Fem | 1980 |
Effect of maternal pyridoxine X HCl supplementation on the vitamin B-6 status of mother and infant and on pregnancy outcome.
Topics: Apgar Score; Aspartate Aminotransferases; Dose-Response Relationship, Drug; Female; Fetal Blood; Hum | 1984 |
Inhibition of puerperal lactation: A comparative study of bromocriptine and pyridoxine.
Topics: Breast; Bromocriptine; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Lactation; Mil | 1980 |
Studies support Bendectin safety claim.
Topics: Antiemetics; Clinical Trials as Topic; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; I | 1981 |
[Our experience in the inhibition of lactation (Controlled clinical study with bromocriptine, methergoline and pyridoxine)].
Topics: Adult; Bromocriptine; Clinical Trials as Topic; Ergolines; Female; Humans; Lactation; Metergoline; P | 1980 |
FDA to reexamine bendectin data.
Topics: Abnormalities, Drug-Induced; Animals; Clinical Trials as Topic; Dicyclomine; Doxylamine; Drug Combin | 1982 |
[Use of dopaminergic drugs (pyridoxine, 2-bromo-alpha-ergocriptine, piribedil) in blocking lactation].
Topics: Bromocriptine; Female; Humans; Lactation; Piperazines; Piribedil; Pregnancy; Prolactin; Pyridoxine | 1980 |
The effects of ascorbic acid, vitamin B6, vitamin B12, and folic acid supplementation on the breast milk and maternal nutritional status of low socioeconomic lactating women.
Topics: Ascorbic Acid; Double-Blind Method; Female; Folic Acid; Humans; Lactation; Milk, Human; Nutritional | 1981 |
Pyridoxine for nausea and vomiting of pregnancy: a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Antiemetics; Double-Blind Method; Female; Humans; Nausea; Placebos; Pregnancy; Pregnancy Comp | 1995 |
Neural tube defects and elevated homocysteine levels in amniotic fluid.
Topics: Adult; Amniotic Fluid; Female; Fetal Diseases; Folic Acid; Gestational Age; Homocysteine; Humans; Ne | 1995 |
Cervical priming with oral misoprostol in pre-labor rupture of membranes at term.
Topics: Administration, Oral; Adult; Cervix Uteri; Delivery, Obstetric; Double-Blind Method; Female; Fetal M | 1996 |
Effect of vitamin B6 on the side effects of a low-dose combined oral contraceptive.
Topics: Adolescent; Adult; Contraceptives, Oral, Combined; Dizziness; Ethinyl Estradiol; Female; Headache; H | 1997 |
Effects of folic acid and vitamin B6 supplementation on women with hyperhomocysteinemia and a history of preeclampsia or fetal growth restriction.
Topics: Dietary Supplements; Female; Fetal Growth Retardation; Folic Acid; Follow-Up Studies; Homocysteine; | 1998 |
Vitamin supplementation and pregnancy outcome in women with recurrent early pregnancy loss and hyperhomocysteinemia.
Topics: Abortion, Habitual; Adult; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; Infant, Ne | 2001 |
Treatment of pregnancy sickness.
Topics: Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Dicyclomine; Double-Blind Method; Doxylamine; | 1977 |
[Relation between the basal levels of prolactin and the degree of breast function during lactation inhibition].
Topics: Adult; Breast; Breast Feeding; Bromocriptine; Clinical Trials as Topic; Diethylstilbestrol; Female; | 1977 |
Failure of pyridoxine to suppress raised serum prolactin levels.
Topics: Chlorpromazine; Female; Galactorrhea; Humans; Lactation; Metabolic Diseases; Pregnancy; Prolactin; P | 1978 |
The failure of pyridoxine in suppression of puerperal lactation.
Topics: Clinical Trials as Topic; Depression, Chemical; Female; Humans; Lactation; Placebos; Postpartum Peri | 1976 |
An evaluation of the teratogenicity of certain antinauseant drugs.
Topics: Abnormalities, Drug-Induced; Antiemetics; Clinical Trials as Topic; Cyclizine; Dicyclomine; Doxylami | 1976 |
Adequacy of vitamin B6 supplementation during pregnancy: a prospective study.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Clinical Enzyme Tests; Erythrocytes; Female; Feta | 1976 |
Suppression of lactation with high doses of pyridoxine.
Topics: Bandages; Breast; Depression, Chemical; Female; Humans; Lactation; Placebos; Pregnancy; Pyridoxine | 1975 |
A deficiency of vitamin B6 is a plausible molecular basis of the retinopathy of patients with diabetes mellitus.
Topics: Aspartate Aminotransferases; Carpal Tunnel Syndrome; Diabetic Retinopathy; Erythrocytes; Female; Fol | 1991 |
Vitamin B6 is effective therapy for nausea and vomiting of pregnancy: a randomized, double-blind placebo-controlled study.
Topics: Adult; Double-Blind Method; Female; Humans; Nausea; Odds Ratio; Pregnancy; Pregnancy Complications; | 1991 |
A longitudinal study of pyridoxine and zinc supplementation of lactating women.
Topics: Adult; Diet; Erythrocytes; Female; Humans; Lactation; Longitudinal Studies; Milk, Human; Nutritional | 1990 |
Maternal drug use and risk of childhood nonlymphoblastic leukemia among offspring. An epidemiologic investigation implicating marijuana (a report from the Childrens Cancer Study Group).
Topics: Adolescent; Age Factors; Antiemetics; Child; Child, Preschool; Dicyclomine; Doxylamine; Drug Combina | 1989 |
Maternal aerobic exercise and vitamin B-6 status.
Topics: Diet; Female; Humans; Osmolar Concentration; Physical Exertion; Pregnancy; Pregnancy Outcome; Pyrido | 1988 |
[Diagnosis and therapy of iron deficiency anemia in pregnancy].
Topics: Anemia, Hypochromic; Ascorbic Acid; Drug Therapy, Combination; Female; Folic Acid; Hematocrit; Hemog | 1986 |
Bromocriptine therapy in normoprolactinemic women with unexplained infertility and galactorrhea.
Topics: Adult; Analysis of Variance; Bromocriptine; Clomiphene; Drug Therapy, Combination; Female; Follow-Up | 1986 |
The creation of therapeutic orphans--or, what have we learnt from the Debendox fiasco?
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Australia; Clinical Trials as Topic; Cyclohexanec | 1985 |
Nutritionally relevant supplementation of vitamin B6 in lactating women: effect on plasma prolactin.
Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Lactation; Milk, Human | 1985 |
[Lactation inhibiting action of pyridoxine].
Topics: Adult; Analgesics; Clinical Trials as Topic; Diethylstilbestrol; Female; Humans; Lactation; Placebos | 1972 |
An antilactogenic effect of pyridoxine.
Topics: Administration, Oral; Clinical Trials as Topic; Diethylstilbestrol; Dihydroxyphenylalanine; Dopamine | 1973 |
[Relations between vitamin B6 status of mother and vitamin B6 nutriture of her newborn infant (author's transl)].
Topics: Adult; Aspartate Aminotransferases; Birth Weight; Chromatography, Ion Exchange; Clinical Trials as T | 1973 |
[The lactation-inhibiting effect of pyridoxine].
Topics: Adult; Diethylstilbestrol; Female; Humans; Lactation; Placebos; Postpartum Period; Pregnancy; Pyrido | 1973 |
[Therapeutic study of Pydoxal (PAL-PO4) in pregnancy toxemia].
Topics: Clinical Trials as Topic; Female; Humans; Placebos; Pre-Eclampsia; Pregnancy; Pyridoxine | 1968 |
'Debendox' in pregnancy sickness.
Topics: Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Female; Humans; Nausea; Parasympatholytics; P | 1971 |
502 other studies available for pyridoxine and Pregnancy
| Article | Year |
|---|---|
Vitamin B status and association with antiseizure medication in pregnant women with epilepsy.
Topics: Adolescent; Adult; Child; Cohort Studies; Cross-Sectional Studies; Epilepsy; Female; Folic Acid; Hum | 2021 |
Impurity-profiling UPLC methods for quantitative analysis of some antiemetics formulated with pyridoxine.
Topics: Acetonitriles; Antiemetics; Chromatography, High Pressure Liquid; Female; Humans; Pregnancy; Pyridox | 2022 |
Comparative dissolution profiles of two anti-emetic delayed release dosage forms of doxylamine and pyridoxine: Xonvea® tablets vs. Cariban® capsules.
Topics: Antiemetics; Doxylamine; Female; Gastrointestinal Agents; Humans; Nausea; Pregnancy; Pyridoxine; Sol | 2022 |
The association of nausea and vomiting of pregnancy, its treatments, and select birth defects: Findings from the National Birth Defect Prevention Study.
Topics: Cleft Palate; Craniosynostoses; Female; Humans; Microphthalmos; Nausea; Pregnancy; Pregnancy Complic | 2023 |
One-carbon metabolism-related nutrients intake is associated with lower risk of preeclampsia in pregnant women: a matched case-control study.
Topics: Case-Control Studies; Choline; Eating; Female; Folic Acid; Humans; Methionine; Nutrients; Pre-Eclamp | 2022 |
Vitamin B6 Levels and Impaired Folate Status but Not Vitamin B12 Associated with Low Birth Weight: Results from the MAASTHI Birth Cohort in South India.
Topics: Birth Cohort; Birth Weight; Female; Folic Acid; Homocysteine; Humans; India; Infant, Low Birth Weigh | 2023 |
Bioavailability of Cariban
Topics: Adult; Antiemetics; Biological Availability; Capsules; Delayed-Action Preparations; Doxylamine; Drug | 2023 |
Lower levels of the neuroprotective tryptophan metabolite, kynurenic acid, in users of estrogen contraceptives.
Topics: Contraceptives, Oral, Hormonal; Estrogens; Female; Humans; Kynurenic Acid; Kynurenine; Pregnancy; Py | 2023 |
Protection Versus Progress: The Challenge of Research on Cannabis Use During Pregnancy.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Approval; Drug Combinations; Ethics, Research; Female; Hu | 2020 |
[Interest of vitamin b6 for treatment of nausea and/or vomiting during pregnancy].
Topics: Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Vitamin B 6; Vomiting | 2020 |
Is ginger really effective for the treatment of the first trimester nausea and vomiting?
Topics: Female; Humans; Nausea; Pregnancy; Pregnancy Trimester, First; Pyridoxine; Vitamin B 6; Vomiting; Zi | 2019 |
Prophylaxis for Tuberculosis in Pregnant Women.
Topics: Adult; Antibiotic Prophylaxis; Antitubercular Agents; Drug Therapy, Combination; Female; Humans; Int | 2019 |
New evidence for concern over the risk of birth defects from medications for nausea and vomitting of pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Antiemetics; Cohort Studies; Dicyclomine; Doxylamine; Drug Combi | 2019 |
Evaluation of the efficacy and safety of bi-daily combination therapy with pyridoxine and doxylamine for nausea and vomiting of pregnancy.
Topics: Administration, Oral; Adult; Antiemetics; Case-Control Studies; Dicyclomine; Dose-Response Relations | 2013 |
The return to the USA of doxylamine-pyridoxine delayed release combination (Diclegis®) for morning sickness--a new morning for American women.
Topics: Antiemetics; Delayed-Action Preparations; Dicyclomine; Doxylamine; Drug Approval; Drug Combinations; | 2013 |
Diclegis for nausea and vomiting of pregnancy.
Topics: Antiemetics; Delayed-Action Preparations; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 2013 |
Characteristics of women with nausea and vomiting of pregnancy who chose to continue compassionate use of placebo after a randomised trial.
Topics: Adult; Dicyclomine; Double-Blind Method; Doxylamine; Drug Combinations; Female; Histamine H1 Antagon | 2013 |
Concern for truth: driving defensively when confronting a zombie epidemic.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Histor | 2013 |
Diclegis: return of a medication.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Approval; Drug Combinations; Female; Humans; Morning Sick | 2013 |
FDA approval of doxylamine-pyridoxine therapy for use in pregnancy.
Topics: Antiemetics; Congenital Abnormalities; Dicyclomine; Doxylamine; Drug Approval; Drug Combinations; Fe | 2014 |
Should doxylamine-pyridoxine be used for nausea and vomiting of pregnancy?
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 2014 |
Treating morning sickness in the United States--changes in prescribing are needed.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Approval; Drug Combinations; Female; Heart Defects, Conge | 2014 |
Gene expression of porcine blastocysts from gilts fed organic or inorganic selenium and pyridoxine.
Topics: Animal Feed; Animals; Antioxidants; Biomarkers; Blastocyst; Cells, Cultured; Dietary Supplements; Em | 2015 |
Microcytic anemia in a pregnant woman: beyond iron deficiency.
Topics: 5-Aminolevulinate Synthetase; Adult; Anemia, Sideroblastic; Female; Genetic Diseases, X-Linked; Hema | 2015 |
Ondansetron compared with doxylamine and pyridoxine for treatment of nausea in pregnancy: a randomized controlled trial.
Topics: Doxylamine; Female; Humans; Morning Sickness; Ondansetron; Pregnancy; Pyridoxine | 2015 |
Odansetron compared with doxylamine and pyridoxine for treatment of nausea in pregnancy: a randomized controlled trial.
Topics: Doxylamine; Female; Humans; Morning Sickness; Ondansetron; Pregnancy; Pyridoxine | 2015 |
In reply.
Topics: Doxylamine; Female; Humans; Morning Sickness; Ondansetron; Pregnancy; Pyridoxine | 2015 |
Nausea and Vomiting in Early Pregnancy.
Topics: Acupuncture; Antiemetics; Female; Humans; Hydrocortisone; Hyperemesis Gravidarum; Metoclopramide; Mo | 2015 |
The importance of pyridoxine for the impact of the dietary selenium sources on redox balance, embryo development, and reproductive performance in gilts.
Topics: Animals; Dietary Supplements; Embryo, Mammalian; Female; Pregnancy; Pyridoxine; Reproduction; Seleni | 2016 |
Flawed invisible trial underpins US morning sickness drug, researchers say.
Topics: Antiemetics; Clinical Trials as Topic; Dicyclomine; Doxylamine; Drug Approval; Drug Combinations; Fe | 2017 |
Motherisk and Canadian Family Physician.
Topics: Canada; Doxylamine; Female; Guideline Adherence; Humans; Hyperemesis Gravidarum; Physicians, Family; | 2017 |
Epileptic status refractory to conventional treatment caused by vitamin B6 deficiency.
Topics: Adult; Female; Humans; Infusions, Intravenous; Pregnancy; Pyridoxine; Status Epilepticus; Vitamin B | 2009 |
Long-term neurodevelopment of children exposed to maternal nausea and vomiting of pregnancy and diclectin.
Topics: Adult; Antiemetics; Child; Child Development; Child, Preschool; Cohort Studies; Dicyclomine; Doxylam | 2009 |
Antenatal treatment in two Dutch families with pyridoxine-dependent seizures.
Topics: Child, Preschool; Female; Fetal Diseases; Fetus; Humans; Infant; Infant, Newborn; Magnetic Resonance | 2010 |
Pyridoxine in pregnant women receiving antituberculous drugs.
Topics: Antitubercular Agents; Female; Humans; Isoniazid; Nervous System Diseases; Pregnancy; Pregnancy Comp | 2009 |
Recurrent postpartum cerebral sinus vein thrombosis as a presentation of cystathionine-beta-synthase deficiency.
Topics: Adult; Anticoagulants; Anticonvulsants; Epilepsy; Female; Folic Acid; Homocystinuria; Humans; Hyperh | 2010 |
Pyridoxine might not have a preventive effect on the retinyl palmitate-induced viscerocranial anomalies.
Topics: Animals; Brain; Cesarean Section; Craniofacial Abnormalities; Digestive System Abnormalities; Diterp | 2010 |
Pyridoxine hydrochloride (vitamin B) in emesis and hyperemesis gravidica.
Topics: Female; Humans; Pregnancy; Pregnancy Complications; Pyridoxine; Vomiting | 1946 |
FAILURE of pyridoxine therapy in nausea and vomiting of pregnancy.
Topics: Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Vomiting | 1946 |
Pyridoxine failure in nausea and vomiting of pregnancy.
Topics: Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Vomiting | 1946 |
Systemic bioavailability and pharmacokinetics of the doxylamine-pyridoxine delayed-release combination (Diclectin).
Topics: Adult; Antiemetics; Biological Availability; Canada; Delayed-Action Preparations; Dicyclomine; Doxyl | 2011 |
Status epilepticus in a neonate treated with pyridoxine because of a familial recurrence risk for antiquitin deficiency: pyridoxine toxicity?
Topics: Adult; Aldehyde Dehydrogenase; Epilepsy; Female; Humans; Infant; Infant, Newborn; Infusions, Parente | 2011 |
Epidemiological evidence in forensic pharmacovigilance.
Topics: Abnormalities, Drug-Induced; Antiemetics; Breast Implantation; Causality; Connective Tissue Diseases | 2012 |
Long-term outcome in pyridoxine-dependent epilepsy.
Topics: Adolescent; Age Factors; Aldehyde Dehydrogenase; Brain; Child; Child, Preschool; Cohort Studies; Cor | 2012 |
Reproductive fitness in maternal homocystinuria due to cystathionine beta-synthase deficiency.
Topics: Adolescent; Adult; Amino Acids; Amino Acids, Sulfur; Child; Child, Preschool; Cystathionine beta-Syn | 2002 |
The management of nausea and vomiting of pregnancy.
Topics: Algorithms; Anti-Inflammatory Agents; Antiemetics; Complementary Therapies; Cost of Illness; Decisio | 2002 |
Protective effect of HSV-mediated gene transfer of nerve growth factor in pyridoxine neuropathy demonstrates functional activity of trkA receptors in large sensory neurons of adult animals.
Topics: Animals; Behavior, Animal; Cell Survival; Cells, Cultured; Embryo, Mammalian; Enzyme-Linked Immunoso | 2003 |
Prenatal prescription of macrolide antibiotics and infantile hypertrophic pyloric stenosis.
Topics: Anti-Bacterial Agents; Confounding Factors, Epidemiologic; Dicyclomine; Doxylamine; Drug Combination | 2003 |
Bendectin and birth defects: hopefully, the final chapter.
Topics: Abnormalities, Drug-Induced; Adult; Adverse Drug Reaction Reporting Systems; Animals; Antiemetics; C | 2003 |
Bendectin and birth defects. II: Ecological analyses.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Adverse Drug Reaction Reporting Systems | 2003 |
[Reproductive toxicity of metadoxine in rats].
Topics: Animals; Dose-Response Relationship, Drug; Drug Combinations; Female; Fertility; Fetal Weight; Male; | 2003 |
Comparison of ovarian and pituitary hormones for maintenance of pregnancy in pyridoxine-deficient rats.
Topics: Animals; Estrogens; Female; Gonadotropins; Gonadotropins, Pituitary; Pituitary Diseases; Pituitary G | 1953 |
Disturbance of vitamin B6 metabolism in pregnancy. II. The influence of various amounts of pyridoxine hydrochloride upon the abnormal tryptophane load test in pregnant women.
Topics: Body Fluids; Female; Humans; Leadership; Pregnancy; Pyridoxine; Riboflavin; Tryptophan; Xanthurenate | 1953 |
Observations on pyridoxine metabolism in pregnancy.
Topics: Female; Humans; Pregnancy; Pregnancy Complications; Pyridoxine; Tryptophan; Vitamin B 6 Deficiency | 1955 |
Pyridoxine in human nutrition, with pregnancy relationships.
Topics: Biochemical Phenomena; Female; Humans; Nutritional Physiological Phenomena; Nutritional Sciences; Nu | 1955 |
Influence of pyridoxine on transaminase activity of human placenta, maternal and fetal blood.
Topics: Blood; Female; Fetal Blood; Fetus; Humans; Placenta; Pregnancy; Pyridoxine; Transaminases; Vitamin B | 1955 |
[Treatment of hyperemesis gravidarum with combined inositol and pyridoxine].
Topics: Female; Humans; Hyperemesis Gravidarum; Inositol; Pregnancy; Pregnancy Complications; Pyridoxine; Vi | 1955 |
The influence of pyridoxine on iron absorption in the pregnant Bantu.
Topics: Black People; Female; Humans; Iron; Leadership; Pregnancy; Pyridoxine; Vitamin B 6 | 1956 |
The influence of pyridoxine on iron absorption in the pregnant Bantu.
Topics: Black People; Female; Humans; Iron; Leadership; Pregnancy; Pyridoxine; Vitamin B 6 | 1956 |
The influence of pyridoxine on iron absorption in the pregnant Bantu.
Topics: Black People; Female; Humans; Iron; Leadership; Pregnancy; Pyridoxine; Vitamin B 6 | 1956 |
The influence of pyridoxine on iron absorption in the pregnant Bantu.
Topics: Black People; Female; Humans; Iron; Leadership; Pregnancy; Pyridoxine; Vitamin B 6 | 1956 |
Bendectin in the treatment of nausea of pregnancy.
Topics: Dicyclomine; Doxylamine; Drug Combinations; Histamine H1 Antagonists; Muscle Relaxants, Central; Nau | 1957 |
Evaluation of cyclizine with pyridoxine in vomiting of pregnancy.
Topics: Cyclizine; Female; Histamine H1 Antagonists; Pregnancy; Pregnancy Complications; Pyridoxine; Vitamin | 1957 |
Nausea and vomiting of pregnancy: treatment with bendectin.
Topics: Dicyclomine; Doxylamine; Drug Combinations; Histamine H1 Antagonists; Muscle Relaxants, Central; Nau | 1958 |
[Pyridoxine therapy of vomiting in pregnancy].
Topics: Female; Pregnancy; Pregnancy Complications; Pyridoxine; Vitamin B 6; Vomiting | 1959 |
Pyridoxine in the treatment of herpes gestationis.
Topics: Dermatitis Herpetiformis; Female; Humans; Pemphigoid Gestationis; Pregnancy; Pregnancy Complications | 1961 |
Enzymatic studies on pyridoxine metabolism. VI. Pyridoxine metabolism in pregnancy.
Topics: Humans; Pregnancy; Pyridoxine; Vitamin B 6 | 1961 |
Evaluation of a combination of meclizine and pyridoxine in the control of nausea and vomiting in pregnancy.
Topics: Anti-Allergic Agents; Female; Histamine H1 Antagonists; Humans; Hyperemesis Gravidarum; Meclizine; N | 1960 |
Clinical experience with a combination of trimethobenzamide and pyridoxine in patients with nausea and vomiting of pregnancy.
Topics: Antiemetics; Benzamides; Female; Humans; Hyperemesis Gravidarum; Nausea; Pregnancy; Pregnancy Compli | 1960 |
Bendectin in the treatment of nausea and vomiting in pregnancy.
Topics: Dicyclomine; Doxylamine; Drug Combinations; Histamine H1 Antagonists; Muscle Relaxants, Central; Nau | 1959 |
Control of nausea and vomiting of pregnancy with rimethobenzamide and pyridoxine.
Topics: Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Vitamin B 6; Vomiting | 1962 |
Nausea and vomiting in pregnancy. A trial of meclozine dihydrochloride with and without pyridoxine.
Topics: Antiemetics; Female; Humans; Hyperemesis Gravidarum; Meclizine; Nausea; Pregnancy; Pyridoxine; Vomit | 1962 |
The effects of pyridoxine supplements on the dental caries experience of pregnant women.
Topics: Dental Caries; Dietary Supplements; Female; Humans; Pregnancy; Pregnancy Complications; Pyridoxine; | 1962 |
Pyridoxine supplementation during pregnancy. Clinical and laboratory observations.
Topics: Cholesterol; Dietary Supplements; Glycosuria; Hemoglobins; Humans; Pregnancy; Pyridoxine; Transamina | 1963 |
[On the vitamin B6 content of human whole blood. Variations of the B6 level in maternal and fetal blood during labor].
Topics: Family; Female; Fetal Blood; Humans; Labor, Obstetric; Maternal-Fetal Exchange; Pregnancy; Pyridoxin | 1962 |
"Ancoloxin" and foetal abnormalities.
Topics: Congenital Abnormalities; Female; Meclizine; Pregnancy; Pregnancy Complications; Pyridoxine | 1962 |
A technique for controlled survey of case records.
Topics: Anti-Allergic Agents; Congenital Abnormalities; Histamine H1 Antagonists; Medical Records; Muscle Re | 1963 |
SIGNS OF PYRIDOXINE DEPENDENCY MANIFEST AT BIRTH IN SIBLINGS.
Topics: Epilepsy; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Parturition; Physical | 1963 |
[USE OF CHLOROPHENOTHIAZINYLSCOPINE IN HYPEREMESIS GRAVIDARUM].
Topics: Antipsychotic Agents; Female; Humans; Hyperemesis Gravidarum; Phenothiazines; Pregnancy; Procaine; P | 1963 |
[NEURITIS AND POLYNEURITIS IN PREGNANCY AND PUERPERIUM].
Topics: Corrinoids; Dexamethasone; Female; Humans; Neuritis; Pathology; Postpartum Period; Pregnancy; Pregna | 1963 |
HYPEREMESIS GRAVIDARUM.
Topics: Blood Chemical Analysis; Female; Humans; Hyperemesis Gravidarum; Meclizine; Nausea; Pathology; Pregn | 1964 |
A DOUBLE BLIND STUDY OF FLUPHENAZINE WITH PYRIDOXINE.
Topics: Biometry; Double-Blind Method; Female; Fluphenazine; Humans; Hyperemesis Gravidarum; Placebos; Pregn | 1964 |
MATERNAL DRUG THERAPY AND CONGENITAL CATARACTS.
Topics: Abnormalities, Drug-Induced; Analgesics; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Antipyreti | 1964 |
PRIDOXINE DEFICIENCY AND PYRIDOXINE DEPENDENCY IN INFANTS AND CHILDREN.
Topics: Biochemical Phenomena; Biochemistry; Child; Epilepsy; Female; Genetics, Medical; Humans; Infant; Inf | 1964 |
[APROPOS OF THE TREATMENT OF HYPEREMESIS GRAVIDARUM].
Topics: Female; Humans; Hyperemesis Gravidarum; Meclizine; Pregnancy; Pyridoxine | 1964 |
HERPES GESTATIONIS.
Topics: Communicable Diseases; Dermatitis Herpetiformis; Drug Therapy; Egypt; Female; Humans; Pathology; Pem | 1963 |
[FAINTING AND NAUSEA OF PREGNANCY. ITS THERAPY WITH A COMBINATION OF A NEW POORLY SOLUBLE SALT OF DIPHENHYDRAMINE, SCOPOLAMINE AND PYRIDOXINE].
Topics: Diphenhydramine; Female; Humans; Hyperemesis Gravidarum; Nausea; Pharmacology; Pregnancy; Pyridoxine | 1963 |
[ON THE CLINICAL PICTURE OF VITAMIN B6 (PYRIDOXINE) DEPENDENCE IN NEWBORN INFANTS].
Topics: Electroencephalography; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Maternal | 1964 |
THE METABOLISM OF ALPHA-N-MONOMETHYL-L-TRYPTOPHAN (L-ABRIN) IN MAN AND IN NORMAL AND PYRIDOXINE DEFICIENT RATS.
Topics: Abrin; Amino Acids; Body Fluids; Eclampsia; Female; Humans; Kynurenine; Male; Niacin; Niacinamide; P | 1964 |
AN EFFECTIVE CONTROL OF NAUSEA AND VOMITING IN PREGNANCY.
Topics: Drug Therapy; Female; Humans; Nausea; Pregnancy; Pyridoxine; Toxicology; Vomiting | 1965 |
HERPES GESTATIONIS.
Topics: Adrenal Cortex Hormones; Drug Therapy; Female; Herpesviridae Infections; Humans; Pemphigoid Gestatio | 1965 |
[ASSOCIATION OF VITAMINS B 1 AND B 6 IN HIGH DOSES IN THERAPY OF HYPEREMESIS GRAVIDARUM].
Topics: Female; Humans; Hyperemesis Gravidarum; Pregnancy; Pyridoxine; Thiamine; Vitamins | 1965 |
EFFECT OF HIGH INTAKES OF THIAMINE, RIBOFLAVIN AND PYRIDOXINE ON REPRODUCTION IN RATS AND VITAMIN REQUIREMENTS OF THE OFFSPRING.
Topics: Animals; Animals, Newborn; Breast Feeding; Diet; Female; Growth; Humans; Lactation; Metabolism; Preg | 1965 |
[Adrenal cortex hormones and pyridoxine in therapy of hyperemesis gravidarum].
Topics: Adrenal Cortex; Adrenal Cortex Hormones; Female; Hyperemesis Gravidarum; Pregnancy; Pregnancy Compli | 1955 |
Supplementation of the swine gestation diet with pyridoxine.
Topics: Animals; Diet; Dietary Supplements; Female; Humans; Nutrition Assessment; Pregnancy; Prenatal Nutrit | 1960 |
Diclectin therapy for nausea and vomiting of pregnancy: effects of optimal dosing.
Topics: Adult; Antiemetics; Dose-Response Relationship, Drug; Doxylamine; Drug Combinations; Female; Humans; | 2003 |
Pharmacorefractory status epilepticus due to low vitamin B6 levels during pregnancy.
Topics: Adult; Electroencephalography; Female; Humans; Pregnancy; Pyridoxine; Status Epilepticus; Vitamin B | 2004 |
Maintenance of pregnancy in pyridoxine-deficient rats when injected with estrone and progesterone.
Topics: Animals; Contraceptive Agents, Female; Estrogens; Estrone; Female; Humans; Pregnancy; Progesterone; | 1951 |
Maternal dietary B vitamin intake, other than folate, and the association with orofacial cleft in the offspring.
Topics: Adult; Case-Control Studies; Cleft Lip; Cleft Palate; Diet; Energy Intake; Female; Folic Acid; Human | 2004 |
Oral pyridoxine during pregnancy : potential protective effect for cardiovascular malformations.
Topics: Adult; Case-Control Studies; Data Interpretation, Statistical; Databases, Factual; Dietary Supplemen | 2004 |
The use of pyridoxine and suprarenal cortex combined in the treatment of nausea and vomiting of pregnancy.
Topics: Female; Folic Acid; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Vitamin B Comple | 1949 |
EVALUATION OF TRIMETHOBENZAMIDE WITH PYRIDOXINE IN NAUSEA AND VOMITING OF PREGNANCY.
Topics: Benzamides; Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Vomiting | 1963 |
Two successful pregnancies in pyridoxine-nonresponsive homocystinuria.
Topics: Abortion, Spontaneous; Adult; Anticoagulants; Betaine; Diet, Protein-Restricted; Female; Gastrointes | 2004 |
Pre-pregnant prediction of recurrent preeclampsia in normotensive thrombophilic formerly preeclamptic women receiving prophylactic antithrombotic medication.
Topics: Adult; Birth Weight; Blood Pressure; Cardiac Output; Female; Fibrinolytic Agents; Folic Acid; Heart | 2005 |
Successful treatment of pyridoxine-unresponsive homocystinuria with betaine in pregnancy.
Topics: Adult; Betaine; Female; Gastrointestinal Agents; Homocystinuria; Humans; Pregnancy; Pregnancy Compli | 2006 |
American Gastroenterological Association institute medical position statement on the use of gastrointestinal medication in pregnancy.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Gastrointestinal Agents; Gastrointe | 2007 |
Preventing recurrence of severe morning sickness.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Morning Sickness; Ondansetr | 2006 |
Pyridoxine-dependent seizures: a family phenotype that leads to severe cognitive deficits, regardless of treatment regime.
Topics: Administration, Oral; Adolescent; Aldehyde Dehydrogenase; Anticonvulsants; Brain; Child; Child, Pres | 2007 |
Pyridoxine-related metabolite concentrations in normal and Down syndrome amniotic fluid.
Topics: Amniotic Fluid; Biomarkers; Case-Control Studies; Down Syndrome; Female; Humans; Kynurenine; Oxalic | 2008 |
Cystathioninuria: management.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Amino Acids; Amniotic Fluid; Child; Child, Preschool; C | 1967 |
Familial intrauterine convulsions in pyridoxine dependency.
Topics: Adult; Aspartate Aminotransferases; Electroencephalography; Erythrocytes; Female; Fetal Diseases; Hu | 1967 |
[Attempt of evaluation of the effect of vitamin B 6 on the level of iron and copper in women in the 3rd trimester of pregnancy].
Topics: Copper; Female; Humans; Iron; Pregnancy; Pyridoxine | 1967 |
Effect of abrupt ration change on rumen microorganisms and the niacin and vitamin B-6 content of rumen fluid and milk.
Topics: Animal Feed; Animals; Cattle; Diet; Edible Grain; Female; Intestines; Lactation; Medicago sativa; Mi | 1967 |
Pregnancy anemia with special reference to folic acid deficiency.
Topics: Anemia; Female; Folic Acid; Folic Acid Deficiency; Hemoglobinometry; Humans; Iron; Pregnancy; Pregna | 1967 |
Safety of Debendox.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Fetal Death; Humans | 1981 |
Debendox in pregnancy.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Fetus; Humans; Infa | 1981 |
Bendectin (Debendox) and congenital diaphragmatic hernia.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Fetus; Hernia, Diaphragmatic; Herni | 1983 |
Bendectin (debendox) and congenital diaphragmatic hernia.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Hernias, Diaphragmatic, Congenital; | 1983 |
Chromosomal studies on children with phocomelia, exposed to debendox during early pregnancy.
Topics: Chromosome Inversion; Dicyclomine; Doxylamine; Drug Combinations; Ectromelia; Female; Humans; Infant | 1983 |
Teratogenicity of debendox and pyrimethamine.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Pregnancy; | 1983 |
Drugs for nausea and vomiting of pregnancy.
Topics: Ethanolamines; Female; Histamine H1 Antagonists; Humans; Nausea; Phenothiazines; Pregnancy; Pregnanc | 1983 |
Debendox is not thalidomide.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 1984 |
Our bundle of responsibility. Presidential address.
Topics: Abnormalities, Drug-Induced; Costs and Cost Analysis; Delivery of Health Care; Dicyclomine; Doxylami | 1984 |
Vitamin cofactor saturation indices for riboflavin, thiamine, and pyridoxine in placental tissue of Kenyan women.
Topics: Adolescent; Adult; Amine Oxidase (Copper-Containing); Avitaminosis; Birth Weight; Coenzymes; Erythro | 1983 |
Pyloric stenosis and maternal Bendectin exposure.
Topics: Adult; Dicyclomine; Doxylamine; Drug Combinations; Drug Prescriptions; Female; Follow-Up Studies; Hu | 1984 |
Possible association of use of bendectin during early pregnancy and congenital lung hypoplasia.
Topics: Abnormalities, Drug-Induced; Adult; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; | 1984 |
Debendox and pregnancy.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Pre | 1984 |
Analyzed vitamin B-6 intakes of pregnant and postpartum lactating and nonlactating women.
Topics: Adolescent; Adult; Diet; Diet Surveys; Female; Humans; Lactation; Postpartum Period; Pregnancy; Pyri | 1984 |
Vitamin B6 supplementation during pregnancy and the vitamin-B6-status of the reproductive product.
Topics: Animals; Diet; Female; Fetus; Mammary Glands, Animal; Placenta; Pregnancy; Pyridoxine; Rats; Rats, I | 1984 |
Vitamin status during puerperium and lactation.
Topics: Adult; Ascorbic Acid; Biotin; Carotenoids; Female; Folic Acid; Humans; Lactation; Postpartum Period; | 1984 |
Debendox: a statement from the New Zealand Adverse Drug Reactions Committee.
Topics: Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 1984 |
No more bendectin.
Topics: Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combinations; Drug Industry; Female; Huma | 1983 |
Bendectin and pyloric stenosis.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Infant, Newborn; Pregnancy; | 1983 |
Effects of an antenatal load of pyridoxine (vitamin B6) on the blood oxygen affinity and prolactin levels in newborn infants and their mothers.
Topics: Administration, Oral; Breast Feeding; Female; Fetal Blood; Humans; Infant, Newborn; Injections, Intr | 1983 |
Bendectin: the wrong way to regulate drug availability.
Topics: Abnormalities, Drug-Induced; Canada; Dicyclomine; Doxylamine; Drug Combinations; Drug Industry; Fema | 1983 |
Nausea of pregnancy: a "natural" remedy.
Topics: Female; Humans; Hyperemesis Gravidarum; Pregnancy; Pyridoxine | 1983 |
Nausea and vomiting of pregnancy.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Pregnancy; Pregnanc | 1983 |
Bendectin: a case of mourning sickness.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Pregnancy; Pregnanc | 1983 |
Two legal issues: expert witnesses and Bendectin case.
Topics: Dicyclomine; Doxylamine; Drug Combinations; Expert Testimony; Female; Humans; Jurisprudence; Pregnan | 1983 |
Birth defects in relation to Bendectin use in pregnancy. II. Pyloric stenosis.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Hyperemesis | 1983 |
Bendectin and pyloric stenosis in infants.
Topics: Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange | 1983 |
Additional follow-up of congenital limb disorders in relation to Bendectin use.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Follow | 1983 |
The innocent bystander. Doxylamine/dicyclomine/pyridoxine and congenital limb defects.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Dose-Response Relationship, Drug; Doxylamine; | 1984 |
Good-bye, Bendectin, old friend.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Drug Industry; Female; Huma | 1984 |
Debendox withdrawn.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Infant, New | 1984 |
Therapeutic drugs in pregnancy. Caution is the watchword.
Topics: Abnormalities, Drug-Induced; Analgesics; Anti-Bacterial Agents; Anti-Infective Agents; Anticonvulsan | 1984 |
Product liability all dressed up American style.
Topics: Antiemetics; Dicyclomine; Diethylstilbestrol; Doxylamine; Drug Combinations; Drug Industry; Drug Lab | 1981 |
Debendox in early pregnancy and fetal malformation.
Topics: Abnormalities, Drug-Induced; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combinations | 1981 |
The effects of pyridoxine on pituitary hormone secretion in amenorrhea-galactorrhea syndromes.
Topics: Adult; Amenorrhea; Chlorpromazine; Female; Galactorrhea; Humans; Lactation Disorders; Levodopa; Pitu | 1982 |
Effect of maternal vitamin B-6 deficiency on specific regions of developing rat brain: amino acid metabolism.
Topics: Amino Acids; Animals; Body Weight; Brain; Diet; Female; Models, Biological; Organ Size; Pregnancy; P | 1983 |
Prospective study of suspected associations between certain drugs administered during early pregnancy and congenital malformations.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Estradiol; Fem | 1983 |
Congenital malformations.
Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Dicyclomine; Doxylamine; Drug Combinations; F | 1983 |
The Bendectin Saga: another American tragedy (Brent, '80).
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Jurispruden | 1983 |
Therapy of side effects of oral contraceptive agents with vitamin B6.
Topics: Contraceptives, Oral; Contraceptives, Oral, Hormonal; Depressive Disorder; Dose-Response Relationshi | 1982 |
Debendox in the dock.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug | 1980 |
Bendectin use during pregnancy.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Pregnancy; | 1982 |
Pyridoxine-responsive herpes gestationis.
Topics: Adult; Female; Humans; Pemphigoid Gestationis; Pregnancy; Pregnancy Complications; Pyridoxine; Skin | 1982 |
Bendectin and fetal development. A study of Boston City Hospital.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug | 1982 |
Bendectin PPI available.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Drug Labeling; Female; Humans; Patient Educ | 1982 |
Debendox does not cause the Poland anomaly.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Antiemetics; Dicyclomine; Doxylamine; Drug Com | 1982 |
Biochemical assessment of vitamin B6 nutritional status in pregnant women with orolingual manifestations.
Topics: Adult; Female; Humans; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Third; Pyridoxic Aci | 1982 |
Maternal plasma concentration of pyridoxal phosphate during pregnancy: adequacy of vitamin B6 supplementation during isoniazid therapy.
Topics: Female; Humans; Isoniazid; Pregnancy; Pregnancy Complications; Pregnancy Complications, Infectious; | 1982 |
[The effect of prenatal administration of vitamin B6 on the blood oxygen transport serum prolactin level in the mother and her newborn infant].
Topics: Female; Humans; Infant, Newborn; Oxygen; Oxygen Consumption; Pregnancy; Prenatal Care; Prolactin; Py | 1982 |
Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Female; Fluphenazine; | 1982 |
Pyridoxine for the suppression of lactation--a clinical trial on 1592 cases.
Topics: Adolescent; Adult; Female; Humans; Labor, Obstetric; Lactation; Postpartum Period; Pregnancy; Prolac | 1982 |
Bendectin (Debendox) as a risk factor for pyloric stenosis.
Topics: Abnormalities, Drug-Induced; Adult; Dicyclomine; Doxylamine; Drug Combinations; Female; Heart Defect | 1982 |
Vitamin B6 reduces cortisone-induced cleft palate in the mouse.
Topics: Abnormalities, Drug-Induced; Animals; Cells, Cultured; Cleft Palate; Cortisone; Female; Kinetics; Ma | 1982 |
Superiority of bromocriptine over pyridoxine in the treatment of patients with acromegaly or galactorrhea.
Topics: Acromegaly; Adult; Aged; Blood Pressure; Bromocriptine; Drug Evaluation; Female; Galactorrhea; Human | 1980 |
Role of placenta in maternal-fetal vitamin transfer in humans.
Topics: Adolescent; Adult; Biotin; Female; Folic Acid; Humans; Maternal-Fetal Exchange; Nicotinic Acids; Pan | 1981 |
Vitamin B-6 metabolism and turnover in the ethanol-fed rat.
Topics: Alcoholism; Animals; Body Weight; Brain; Female; Humans; Liver; Male; Organ Size; Organophosphorus C | 1982 |
Vitamin B-6 and plasma PLP in pregnancy, lactation.
Topics: Animals; Copper; Female; Humans; Lactation; Pregnancy; Pyridoxal Phosphate; Pyridoxine; Rats | 1981 |
The law and Bendectin.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Jurispruden | 1981 |
Indications for bendectin narrowed.
Topics: Antiemetics; Carcinogens; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Pregnancy; Pre | 1981 |
Effects of vitamin B-6 deficiency during lactation on the vitamin B-6 content of milk, liver and muscle of rats.
Topics: Animals; Diet; Female; Kinetics; Lactation; Liver; Maternal-Fetal Exchange; Milk; Muscles; Pregnancy | 1981 |
Pyridoxal 5'-phosphate in whole blood, plasma and blood cells of postpartum nonlactating and lactating rats and their pups.
Topics: Animals; Diet; Erythrocytes; Female; Hematocrit; Lactation; Male; Postpartum Period; Pregnancy; Pyri | 1981 |
Is Bendectin a teratogen?
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Drug Evaluatio | 1981 |
Birth defects related to bendectin use in pregnancy. I. Oral clefts and cardiac defects.
Topics: Antiemetics; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Drug Combinations; Drug Evaluation; F | 1981 |
Congenital anomalies in relation to the use of doxylamine/dicyclomine and other antenatal factors: an ongoing prospective study.
Topics: Abnormalities, Drug-Induced; Adult; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combi | 1981 |
Debendox and limb reduction deformities.
Topics: Abnormalities, Drug-Induced; Australia; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug C | 1981 |
Vitamin B6 status of low-income adolescent and adult pregnant women and the condition of their infants at birth.
Topics: Adolescent; Adult; Alanine Transaminase; Apgar Score; Birth Weight; Diet; Erythrocytes; Female; Huma | 1981 |
[Influence of the dietary level of vitamin B6 on the vitamin nutritional status of the lactating rat and the litter (author's transl)].
Topics: Analysis of Variance; Animals; Animals, Suckling; Diet; Female; Gastric Juice; Lactation; Liver; Mil | 1981 |
Erythrocyte glutamate transaminase levels in normal and pre-eclamptic pregnancies.
Topics: Aspartate Aminotransferases; Erythrocytes; Female; Humans; Pre-Eclampsia; Pregnancy; Pregnancy Trime | 1981 |
A dearth of new drugs.
Topics: Abnormalities, Drug-Induced; Antiemetics; Doxylamine; Drug Combinations; Drug Evaluation; Drug Evalu | 1980 |
Debendox in pregnancy.
Topics: Abnormalities, Drug-Induced; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combinations | 1980 |
Pyridoxal phosphate concentration in blood in newborn infants and their mothers compared with the amount of extra pyridoxol taken during pregnancy and breast feeding.
Topics: Adolescent; Adult; Breast Feeding; Female; Fetal Blood; Humans; Infant, Newborn; Pregnancy; Pyridoxa | 1980 |
How safe is Bendectin?
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Drug Evaluation; Female; Hu | 1980 |
The effects of vitamin C, vitamin B6, vitamin B12, folic acid, riboflavin, and thiamin on the breast milk and maternal status of well-nourished women at 6 months postpartum.
Topics: Ascorbic Acid; Female; Folic Acid; Humans; Milk, Human; Postpartum Period; Pregnancy; Pyridoxine; Ri | 1980 |
Vitamin B1, B2, B6, and C status in hospital inpatients.
Topics: Adult; Ascorbic Acid; Ascorbic Acid Deficiency; Avitaminosis; Female; France; Humans; Inpatients; Ma | 1980 |
Debendox and congenital malformations in Northern Ireland.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug | 1980 |
The Bendectin debate.
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Femal | 1980 |
Public health issues: bendectin, love canal.
Topics: Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; New York; Pregnancy; Pyridines; Pyridoxi | 1981 |
Vitamin B6 deficiency and dependency.
Topics: Female; Humans; Infant; Infant, Newborn; Pregnancy; Pyridoxine; Seizures; Vitamin B 6 Deficiency | 1980 |
Bendectin and fetal malformations.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 1981 |
Carpal tunnel syndrome during pregnancy: prevalence and blood level of pyridoxine.
Topics: Adult; Carpal Tunnel Syndrome; Cross-Sectional Studies; Female; Humans; Pregnancy; Pregnancy Complic | 1995 |
Vitamin B1, B2 and B6 during the course of pregnancy of rural and urban women in northeast Thailand.
Topics: Adult; Female; Hemoglobins; Humans; Pregnancy; Pyridoxine; Riboflavin; Rural Health; Socioeconomic F | 1995 |
Response of kynurenine pathway enzymes to pregnancy and dietary level of vitamin B-6.
Topics: Animals; Diet; Female; Hydrolases; Kynurenine; Liver; Lyases; Mice; Mice, Inbred A; Mice, Inbred DBA | 1995 |
Vitamin B-6 and ginger in morning sickness.
Topics: Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Spices; Vomiting | 1995 |
Gallstones in pregnancy.
Topics: Cholelithiasis; Drug Therapy, Combination; Female; Humans; Phosphatidylcholines; Pregnancy; Pregnanc | 1995 |
Congenital symmetrical weakness of the upper limbs resembling brachial plexus palsy: a possible sequel of drug toxicity in first trimester of pregnancy?
Topics: Age of Onset; Antiemetics; Arm; Dermatoglyphics; Diagnosis, Differential; Dicyclomine; Doxylamine; D | 1995 |
A case of lipomeningocele reported with fluoxetine (and alprazolam, vitamins B1 and B6, heptaminol) prescribed during pregnancy.
Topics: Adult; Alprazolam; Depression; Drug Therapy, Combination; Female; Fluoxetine; Heptaminol; Humans; In | 1995 |
Change in blood levels of vitamin B-6 derivatives in pregnant and lactating rats.
Topics: Animals; Chromatography, High Pressure Liquid; Erythrocytes; Female; Lactation; Nutritional Status; | 1994 |
Science, law, and the search for truth in the courtroom: lessons from Daubert v. Merrell Dow.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Expert Testimo | 1994 |
Admissibility of scientific testimony into evidence.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Drug Industry; | 1994 |
Study of prescription drugs in the first trimester and congenital malformations.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Pregnancy; | 1993 |
Pyridoxine-5'-beta-D-glucoside: metabolic utilization in rats during pregnancy and availability to the fetus.
Topics: Administration, Oral; Animals; Biological Availability; Carbon Radioisotopes; Chromatography, High P | 1993 |
Environmental hazards: real or exaggerated?
Topics: Dicyclomine; Doxylamine; Drug Combinations; Female; Hazardous Substances; Humans; Pregnancy; Pyridox | 1993 |
Vitamin B-6 status indices are lower in pregnant than in nonpregnant women but urinary excretion of 4-pyridoxic acid does not differ.
Topics: Adult; Alkaline Phosphatase; Aspartate Aminotransferases; Chromatography, High Pressure Liquid; Eryt | 1993 |
Supreme Court to weigh science.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Expert Testimo | 1993 |
Periconceptional vitamin profiles are not suitable for identifying women at risk for neural tube defects.
Topics: Ascorbic Acid; Female; Ferritins; Flavin Mononucleotide; Folic Acid; Gestational Age; Humans; Neural | 1993 |
Changes of some vitamin levels during and after normal pregnancy.
Topics: Erythrocytes; Estradiol; Female; Folic Acid; Homeostasis; Humans; Hydrocortisone; Maternal-Fetal Exc | 1995 |
Low vitamin B6 status associated with slow growth in healthy breast-fed infants.
Topics: Anthropometry; Birth Weight; Blood Proteins; Body Height; Breast Feeding; Female; Follow-Up Studies; | 1995 |
Vitamin B1 and B6 substitution in pregnancy for leg cramps.
Topics: Female; Humans; Leg; Muscle Cramp; Pregnancy; Pregnancy Complications; Pyridoxine; Thiamine | 1996 |
Riboflavin and pyridoxine status in a group of pregnant Mexican women.
Topics: Adult; Female; Humans; Infant, Newborn; Mexico; Nutrition Surveys; Pregnancy; Pyridoxine; Riboflavin | 1996 |
[Wilson's disease: a review apropos of a clinical experience in 16 patients].
Topics: Adolescent; Adult; Central Nervous System Diseases; Ceruloplasmin; Child; Child, Preschool; Copper; | 1995 |
In vivo/in vitro studies on the effects of cyclophosphamide on growth and differentiation of hamster palate.
Topics: Animals; Collagen; Cricetinae; Cyclophosphamide; Disease Models, Animal; Drug Therapy, Combination; | 1996 |
Vitamin dependent erythrocyte enzymes in newborns in relation to gestational age and birth weight.
Topics: Aspartate Aminotransferases; Birth Weight; Cohort Studies; Erythrocytes; Female; Fetal Blood; Gestat | 1996 |
Bringing scholarship to the courtroom: the Daubert decision and its impact on the Teratology Society.
Topics: Dicyclomine; Doxylamine; Drug Combinations; Ethics, Professional; Expert Testimony; Female; Humans; | 1995 |
Influence of different dietary vitamin B6 supply during gravidity and lactation on total vitamin B6 concentration (pyridoxine, pyridoxal and pyridoxamine) in blood and milk.
Topics: Analysis of Variance; Animals; Female; Food, Fortified; Lactation; Milk; Pregnancy; Pregnancy, Anima | 1996 |
Effect of feeding various dietary vitamin B6 concentrations during gestation and lactation on vitamin B6 level in liver and carcass of rat dams.
Topics: Animals; Dose-Response Relationship, Drug; Female; Lactation; Liver; Pregnancy; Pregnancy, Animal; P | 1996 |
[The effect of alimentary vitamin B6 supply during pregnancy and lactation on the activity of specific transaminases of lactating rats].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Dose-Response Relationship, Drug; Erythr | 1996 |
Effects of vitamin B6 on beta-aminoproprionitrile-induced palatal cleft formation in the rat.
Topics: Administration, Oral; Aminopropionitrile; Animals; Cleft Palate; Diet; Drug Interactions; Female; Ge | 1997 |
Drug therapies for hyperemesis gravidarum.
Topics: Administration, Oral; Antiemetics; Doxylamine; Female; Humans; Hyperemesis Gravidarum; Infusions, In | 1997 |
A woman with five consecutive fetal deaths: case report and retrospective analysis of hyperhomocysteinemia prevalence in 100 consecutive women with recurrent miscarriages.
Topics: Abortion, Habitual; Adult; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Methyl | 1998 |
Comparative experimental study of Mg lactate, vitamin B6 and their association on the permeability of a human membrane. 1. Effect on the total ionic transfer through isolated amniotic membrane.
Topics: Amnion; Biological Transport; Cell Membrane Permeability; Female; Humans; Infant; Ions; Lactic Acid; | 1997 |
Strategies for the treatment of cystathionine beta-synthase deficiency: the experience of the Willink Biochemical Genetics Unit over the past 30 years.
Topics: Adolescent; Adult; Betaine; Child; Child, Preschool; Cystathionine beta-Synthase; Dose-Response Rela | 1998 |
Dietary intake among adults with special reference to vitamin B6.
Topics: Adult; Aged; Diet; Diet Records; Diet Surveys; Female; Humans; Male; Middle Aged; Nutritional Requir | 1997 |
Folate intake and status among adults in the Netherlands.
Topics: Adult; Aged; Contraceptives, Oral; Diet Records; Female; Folic Acid; Humans; Male; Middle Aged; Neth | 1997 |
Bread fortification with folic acid, vitamin B12, and vitamin B6 in Hungary.
Topics: Anemia, Pernicious; Bread; Female; Folic Acid; Food, Fortified; Humans; Hungary; Neural Tube Defects | 1998 |
Comparative experimental study of Mg lactate, vitamin B6 and their association on the permeability of a human membrane. 2. Effects on cellular and paracellular ionic transfer through isolated amniotic membrane.
Topics: Amnion; Antiporters; Biological Transport; Chloride-Bicarbonate Antiporters; Electrophysiology; Fema | 1998 |
Pregnancy outcome of women exposed to pinaverium due to a dispensing error.
Topics: Antiemetics; Calcium Channel Blockers; Canada; Dicyclomine; Doxylamine; Drug Combinations; Female; F | 1999 |
Enzymic evaluation of thiamin, riboflavin and pyridoxine status of parturient mothers and their newborn infants in a Mediterranean area of Spain.
Topics: Adolescent; Adult; Aspartate Aminotransferases; Female; Fetal Blood; Flavin-Adenine Dinucleotide; Gl | 1999 |
From science to evidence: the testimony on causation in the Bendectin cases.
Topics: Abnormalities, Drug-Induced; Data Collection; Decision Making; Doxylamine; Drug Combinations; Expert | 1993 |
Nausea during pregnancy and congenital heart defects: a population-based case-control study.
Topics: Adolescent; Adult; Antiemetics; Case-Control Studies; Female; Georgia; Heart Defects, Congenital; Hu | 1999 |
[Obstetric problems followed by stroke].
Topics: Abortion, Habitual; Adult; Arteriosclerosis; Cerebral Infarction; Diagnosis, Differential; Female; F | 1999 |
[Primary prevention of developmental abnormalities].
Topics: Abortion, Induced; Anencephaly; Congenital Abnormalities; Female; Folic Acid; Humans; Infant, Newbor | 1999 |
Neonatal seizures after use of pyridoxine in pregnancy.
Topics: Adult; Female; Humans; Infant, Newborn; Pregnancy; Pyridoxine; Seizures; Self Medication; Substance | 1999 |
DNA polymorphism-diet-cofactor-development hypothesis and the gene-teratogen model for schizophrenia and other developmental disorders.
Topics: Alleles; Brain; Diet; Female; Folic Acid; Folic Acid Deficiency; Genetic Linkage; Genotype; Humans; | 1999 |
Prevalence and severity of nausea and vomiting of pregnancy and effect of vitamin supplementation.
Topics: Canada; Dietary Supplements; Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Prevalence; | 1999 |
Nonsyndromic orofacial clefts: association with maternal hyperhomocysteinemia.
Topics: Adult; Case-Control Studies; Child, Preschool; Cleft Lip; Cleft Palate; Erythrocytes; Fasting; Femal | 1999 |
Adequacy of maternal pyridoxine supplementation during pregnancy in relation to the vitamin B6 status and growth of neonates at birth.
Topics: Dietary Supplements; Female; Fetal Blood; Humans; Infant, Newborn; Nutritional Status; Pregnancy; Py | 1999 |
Neonatal seizures after pyridoxine use.
Topics: Breast Feeding; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; | 1999 |
Managing women with nausea and vomiting of pregnancy. Canadian consensus.
Topics: Adult; Anti-Inflammatory Agents; Antiemetics; Asthma; Diagnosis, Differential; Doxylamine; Drug Ther | 2000 |
Prenatal high-dose pyridoxine may prevent hypertension and syndrome X in-utero by protecting the fetus from excess glucocorticoid activity.
Topics: Dose-Response Relationship, Drug; Female; Fetus; Glucocorticoids; Humans; Hypertension; Infant, Newb | 2000 |
Attitudes, management and consequences of nausea and vomiting of pregnancy in the United States and Canada.
Topics: Adult; Antiemetics; Attitude; Attitude of Health Personnel; Canada; Cost of Illness; Dicyclomine; Di | 2000 |
Effects of vitamin B6 supplementation in rats during lactation on vitamin B6 concentration and transaminase activities in the offspring.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Dietary Supplements; Dose-Response Relat | 2000 |
Association effects of vitamin B6 and various magnesium salts on a pharmacological model: the human amniotic membrane.
Topics: Amnion; Analysis of Variance; Electrophysiology; Female; Humans; In Vitro Techniques; Ion Transport; | 2000 |
Appraisal of drug therapy for nausea and vomiting of pregnancy: I. The placebo effect - methodological and practical considerations.
Topics: Female; Humans; Nausea; Placebo Effect; Pregnancy; Pregnancy Complications; Pyridoxine; Randomized C | 2000 |
Selections from current literature. Complementary therapies for nausea and vomiting in early pregnancy.
Topics: Complementary Therapies; Female; Humans; Hyperemesis Gravidarum; Nausea; Phytotherapy; Plants, Medic | 2000 |
The safety of higher than standard dose of doxylamine-pyridoxine (Diclectin) for nausea and vomiting of pregnancy.
Topics: Antiemetics; Doxylamine; Drug Combinations; Female; Humans; Infant, Newborn; Nausea; Pregnancy; Preg | 2001 |
Complete resolution of cervical spinal tuberculosis with paraplegia in pregnancy.
Topics: Adult; Antitubercular Agents; Cervical Vertebrae; Diagnosis, Differential; Female; Humans; Infant, N | 2002 |
Editorial: Vitamin B6 and diabetes.
Topics: Diabetes Mellitus; Female; Glucose; Humans; Pregnancy; Pregnancy in Diabetics; Pyridoxine; Tryptopha | 1976 |
The aetiological role of maternal vitamin-B6 deficiency in the development of atherosclerosis.
Topics: Arteriosclerosis; Blood Vessels; Collagen; Elastin; Female; Humans; Infant, Newborn; Pregnancy; Preg | 1977 |
Lack of acute effects of pyridoxine on prolactin secretion and lactation.
Topics: Adenoma; Animals; Chlorpromazine; Female; Haplorhini; Humans; Lactation; Macaca mulatta; Pituitary N | 1978 |
Pyridoxine (B6)-induced inhibition of prolactin release in the female rat.
Topics: Animals; Castration; Female; Kinetics; Luteinizing Hormone; Methyltyrosines; Pregnancy; Proestrus; P | 1978 |
Dynamic evaluation of prolactin secretion in patients with oligospermia: effects of treatment with metergoline.
Topics: Adult; Ergolines; Female; Humans; Levodopa; Male; Metergoline; Metoclopramide; Oligospermia; Pregnan | 1979 |
[Pyridoxine and hyperprolactinemia].
Topics: Amenorrhea; Animals; Female; Galactorrhea; Haplorhini; Humans; Pregnancy; Prolactin; Pyridoxine; Syn | 1979 |
Vitamin supplementation as a possible factor in the incidence of cleft lip/palate deformities in humans.
Topics: Ascorbic Acid; Calcium; Cleft Lip; Cleft Palate; Female; Folic Acid; Humans; Infant, Newborn; Matern | 1976 |
[Herpes gestationis. Ultrastructural and immunologic data, about two cases (author's transl)].
Topics: Diagnosis, Differential; Female; Humans; Pemphigoid Gestationis; Pemphigus; Pregnancy; Pregnancy Com | 1978 |
More on dangers of vitamin B6 in nursing mothers.
Topics: Breast Feeding; Female; Humans; Infant, Newborn; Lactation; Nutritional Requirements; Pregnancy; Pro | 1979 |
More on dangers of vitamin B6 in nursing mothers.
Topics: Adolescent; Animals; Breast Feeding; Child; Female; Humans; Lactation; Pregnancy; Pyridoxine; Rats; | 1979 |
More on dangers of vitamin B6 in nursing mothers.
Topics: Breast Feeding; Female; Humans; Lactation; Pregnancy; Pyridoxine | 1979 |
[Ptyalismus gravidarum].
Topics: Adult; Dimenhydrinate; Drug Therapy, Combination; Female; Humans; Pregnancy; Pregnancy Complications | 1979 |
Pyridoxine treatment of chemical diabetes in pregnancy.
Topics: Adult; Female; Humans; Pregnancy; Pregnancy in Diabetics; Pyridoxine; Vitamin B 6 Deficiency | 1979 |
The effects of vitamin C, vitamin B6, and vitamin B12 supplementation on the breast milk and maternal status of well-nourished women.
Topics: Ascorbic Acid; Female; Humans; Lactation; Milk, Human; Pregnancy; Pyridoxine; Vitamin B 12 | 1979 |
Inhibition of prolactin by pyridoxine.
Topics: Female; Humans; Lactation; Pregnancy; Prolactin; Pyridoxine | 1979 |
CDC study: no evidence for teratogenicity of Bendectin.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Heart | 1979 |
Vitamin B6 nutriture during pregnancy and lactation. I. Vitamin B6 intake, levels of the vitamin in biological fluids, and condition of the infant at birth.
Topics: Adolescent; Adult; Apgar Score; Female; Fetal Blood; Humans; Infant, Newborn; Lactation; Maternal-Fe | 1979 |
Vitamin B6 nutriture during pregnancy and lactation. II. The effect of long-term use of oral contraceptives.
Topics: Adolescent; Adult; Contraceptives, Oral; Contraceptives, Oral, Combined; Female; Fetal Blood; Humans | 1979 |
Gestational diabetes: diagnosis and treatment.
Topics: Abortion, Therapeutic; Female; Humans; Pregnancy; Pregnancy in Diabetics; Pyridoxine | 1979 |
Ineffectiveness of pyridoxine (B6) to alter secretion of growth hormone and prolactin and absence of therapeutic effects on galactorrhea-amenorrhea syndromes.
Topics: Amenorrhea; Bromocriptine; Female; Galactorrhea; Growth Hormone; Humans; Lactation Disorders; Menstr | 1977 |
Suppression of pimozide-induced prolactin secretion by piridoxine (vitamin B6).
Topics: Adult; Female; Humans; Hypothalamus; Lactation; Levodopa; Male; Pimozide; Pituitary Gland, Anterior; | 1977 |
Dangers of vitamin B6 in nursing mothers.
Topics: Breast Feeding; Female; Humans; Lactation; Pregnancy; Pyridoxine | 1979 |
Ineffectiveness of pyridoxine in evaluation and treatment of the hyperprolactinemic amenorrhea-galactorrhea syndrome.
Topics: Administration, Oral; Adult; Amenorrhea; Drug Evaluation; Female; Galactorrhea; Humans; Injections, | 1979 |
Influence of dietary pyridoxine on selected immune capacities of rat dams and pups.
Topics: Aging; Animals; Animals, Newborn; Antibody-Producing Cells; Body Weight; Diet; Dose-Response Relatio | 1979 |
Vitamin B6 in nursing mothers.
Topics: Female; Lactation; Pregnancy; Prolactin; Pyridoxine | 1979 |
Vitamin B6 in nursing mothers.
Topics: Female; Humans; Infant, Newborn; Lactation; Nutritional Requirements; Pregnancy; Pyridoxine | 1979 |
[Longtime study on bromoergocryptine therapy and pyridoxine therapy of amenorrhea-galactorrhea].
Topics: Amenorrhea; Bromocriptine; Female; Galactorrhea; Humans; Lactation Disorders; Pregnancy; Pyridoxine; | 1979 |
[Female hyperprolactinaemia. 19 cases (author's transl)].
Topics: Adolescent; Adult; Amenorrhea; Bromocriptine; Female; Galactorrhea; Humans; Pituitary Gland; Pregnan | 1979 |
Pyridoxine treatment of galactorrhoea-amenorrhoea syndromes.
Topics: Adult; Amenorrhea; Drug Evaluation; Female; Galactorrhea; Humans; Lactation Disorders; Ovulation; Pr | 1978 |
Influence of dietary pyridoxine on lactation in the rat.
Topics: Aminoisobutyric Acids; Animals; Female; Growth Hormone; Lactation; Mammary Glands, Animal; Milk; Pre | 1978 |
Influence of different levels of dietary pyridoxine on milk composition in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Female; Lactation; Mammary Glands, Animal; Milk; Nutritio | 1978 |
The physical and neuromotor development of progeny of female rats fed graded levels of pyridoxine during lactation.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Female; Growth; Lactation; Motor Skills | 1978 |
Physical and neuromotor development of progeny of pyridoxine-restricted rats cross-fostered with control or isonutritional dams.
Topics: Animals; Female; Lactation; Motor Skills; Musculoskeletal Development; Nervous System; Pregnancy; Pr | 1978 |
Teratogenicity testing in humans: a method demonstrating safety of bendectin.
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylam | 1978 |
Evaluation of the vitamin status in pregnancy. Circulating blood levels and enzyme activation in a group of Dutch parturient women and their full term newborns.
Topics: Enzyme Activation; Female; Folic Acid; Glutathione Reductase; Humans; Infant, Newborn; Pregnancy; Py | 1978 |
Fetal malformation after Debendox treatment in early pregnancy.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug | 1978 |
Vitamin B6 status in women with postpartum depression.
Topics: Adolescent; Adult; Aspartate Aminotransferases; Depression; Enzyme Activation; Female; Humans; Pregn | 1978 |
Effects of vitamin B-6 deficiency on the developing central nervous system of the rat. Gross measurements and cytoarchitectural alterations.
Topics: Animals; Body Weight; Brain; Cell Count; Female; Lactation; Pregnancy; Pregnancy Complications; Purk | 1978 |
Effects of vitamin B-6 deficiency on the developing central nervous system of the rat. Myelination.
Topics: Animals; Axons; Female; Lactation; Nerve Fibers, Myelinated; Pregnancy; Pregnancy Complications; Pyr | 1978 |
Serum vitamin B6 in pure pregnancy depression.
Topics: Adult; Depression; Female; Humans; Pregnancy; Pregnancy Complications; Psychological Tests; Pyridoxi | 1978 |
[Treatment of sideropenic anemia in pregnant women with iron preparations].
Topics: Anemia, Hypochromic; Ascorbic Acid; Drug Therapy, Combination; Female; Ferrous Compounds; Folic Acid | 1978 |
Vitamin B6 nutriture during pregnancy.
Topics: Birth Weight; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pregnancy; Pregnancy Complic | 1978 |
Herpes gestationis ( a case report ).
Topics: Adult; Female; Humans; Pemphigoid Gestationis; Prednisolone; Pregnancy; Pregnancy Complications; Pyr | 1976 |
Vitamin B6 treatment of gestational diabetes mellitus: studies of blood glucose and plasma insulin.
Topics: Blood Glucose; Female; Humans; Insulin; Pregnancy; Pregnancy in Diabetics; Pyridoxine | 1977 |
Congenital deformities associated with Benedectin.
Topics: Abnormalities, Drug-Induced; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combinations | 1977 |
Pregnancy and homocystinuria.
Topics: Amino Acids; Female; Homocystinuria; Humans; Pedigree; Pregnancy; Pregnancy Complications; Pyridoxin | 1977 |
[Inhibition of lactation and of plasma prolactin by administration of pyridoxine].
Topics: Adult; Depression, Chemical; Female; Humans; Lactation; Pregnancy; Prolactin; Pyridoxine | 1977 |
Failure of pyridoxine to improve glucose tolerance in gestational diabetes mellitus.
Topics: Adult; Female; Glucose; Glucose Tolerance Test; Humans; Intestinal Absorption; Pregnancy; Pregnancy | 1977 |
[Effect of dietary level of proteins and lipids on vitamin content of various tissues in the lactating and weanling rat].
Topics: Animals; Body Composition; Dietary Fats; Dietary Proteins; Female; Lactation; Liver; Pregnancy; Pyri | 1977 |
Congenital deformities associated with Bendectin.
Topics: Abnormalities, Drug-Induced; Adult; Cleft Lip; Cleft Palate; Cyclohexanecarboxylic Acids; Dicyclomin | 1977 |
Vitamin levels in low-birth-weight newborn infants and their mothers.
Topics: Biotin; Carotenoids; Female; Fetal Blood; Folic Acid; Humans; Infant, Low Birth Weight; Infant, Newb | 1977 |
Influence of pyridoxine supplementation on vitamin B-6 levels in milk of rats deficient in the vitamin.
Topics: Animals; Body Weight; Diet; Dose-Response Relationship, Drug; Female; Lactation; Male; Milk; Pregnan | 1976 |
Treatment of women with the galactorrhea-amenorrhea syndrome with pyridoxine (vitamin B6).
Topics: Adult; Amenorrhea; Female; Galactorrhea; Humans; Lactation Disorders; Menstruation; Pregnancy; Prola | 1976 |
Effect of oral contraceptives on nutrients. III. Vitamins B6, B12, and folic acid.
Topics: Adolescent; Adult; Aspartate Aminotransferases; Contraceptives, Oral; Contraceptives, Oral, Syntheti | 1976 |
Nutritional support in obstetrics and gynecology.
Topics: Animals; Blood Volume; Body Weight; Calcium; Contraceptives, Oral; Deficiency Diseases; Dietary Prot | 1976 |
Postnatal patterns of brain lipids in progeny of vitamin B-6 deficient rats before and after pyridoxine supplementation.
Topics: Age Factors; Animals; Body Weight; Brain; Cerebellum; Cerebrosides; Cholesterol; Female; Ganglioside | 1976 |
Postnatal patterns of fatty acids in brain of progeny from vitamin B-6 deficient rats before and after pyridoxine supplementation.
Topics: Age Factors; Animals; Brain; Cerebellum; Fatty Acids; Fatty Acids, Unsaturated; Female; Lactation; P | 1976 |
Influence of vitamin B6 intake on the content of the vitamin in human milk.
Topics: Adult; Circadian Rhythm; Female; Humans; Lactation; Milk Proteins; Milk, Human; Nutritional Requirem | 1976 |
[Recommended vitamin intake].
Topics: Adolescent; Adult; Ascorbic Acid; Avitaminosis; Child; Child, Preschool; Female; Folic Acid; Humans; | 1976 |
Neonatal pyridoxine responsive convulsions due to isoniazid therapy.
Topics: Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Isoniazid; Male; Pregnancy; Preg | 1976 |
Maternal and fetal plasma levels of pyridoxal phosphate at term: adequacy of vitamin B6 supplementation during pregnancy.
Topics: Adult; Blood Specimen Collection; Circadian Rhythm; Female; Fetus; Humans; Infant, Newborn; Maternal | 1975 |
Pyridoxal phosphate and hypertensive disorders of pregnancy.
Topics: Administration, Oral; Brain; Female; Fetus; Growth; Humans; Hypertension; Infant, Newborn; Injection | 1975 |
Teratogenicity study in rats given high doses of pyridoxine (vitamin B6) during organogenesis.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Dose-Response Relationship, Drug; Female | 1975 |
Effects of different levels of pyridoxine fed during pregnancy superimposed upon growth in the rat.
Topics: Age Factors; Alanine Transaminase; Animal Nutritional Physiological Phenomena; Animals; Body Weight; | 1975 |
Improvement of oral glucose tolerance in gestational diabetes by pyridoxine.
Topics: Adult; Female; Glucose Tolerance Test; Humans; Pregnancy; Pregnancy in Diabetics; Pyridoxine; Trypto | 1975 |
Management of nursing and nonnursing mothers.
Topics: Abortion, Spontaneous; Administration, Oral; Androgens; Bottle Feeding; Breast Feeding; Contraceptiv | 1975 |
Assessment of vitamin B 6 status. Studies on pregnant women and oral contraceptive users.
Topics: Adolescent; Adult; Aspartate Aminotransferases; Clinical Enzyme Tests; Contraceptives, Oral; Enzyme | 1975 |
Letter: Pyridoxine and oral glucose tolerance in pregnancy.
Topics: Fatty Acids, Nonesterified; Female; Glucose; Glucose Tolerance Test; Humans; Pregnancy; Pyridoxine | 1975 |
[Influence of protein-enriched food on tissue vitamin content in pregnant and lactating rats].
Topics: Animals; Cadaver; Dietary Proteins; Female; Food, Fortified; Lactation; Liver; Pregnancy; Pregnancy, | 1975 |
Further studies on brain gamma-aminobutyric acid metabolism after administration of pyridoxine to vitamin B-6-deficient suckling rats.
Topics: Aminobutyrates; Animals; Aspartate Aminotransferases; Brain; Female; gamma-Aminobutyric Acid; Glutam | 1975 |
Increased lysosomal hydrolase activity in kidney and brain from the vitamin B6-deficient developing rat.
Topics: Acid Phosphatase; alpha-L-Fucosidase; Animals; Blood Urea Nitrogen; Brain; Female; Galactosidases; G | 1975 |
Vitamin metabolism and requirements: some aspects reviewed.
Topics: Alcohol Oxidoreductases; Animals; Ascorbic Acid; Contraceptives, Oral; Female; Horses; Humans; Liver | 1975 |
[Experimental studies concerning the metabolism, the nutriture, and the requirement for vitamin B6 in childhood (author's transl)].
Topics: Anemia, Hypochromic; Celiac Disease; Chemical Phenomena; Chemistry; Child; Child Nutritional Physiol | 1975 |
[Acute hemorrhage from the female genitals].
Topics: Abortion, Spontaneous; Aminocaproates; Ascorbic Acid; Extraembryonic Membranes; Female; Genitalia, F | 1975 |
[Vitamin b6 depletion in women with hyperemesis gravidarum (author's transl)].
Topics: Female; Humans; Hyperemesis Gravidarum; Pregnancy; Pregnancy Trimester, Third; Pyridoxine; Vitamin B | 1975 |
[Toxicity of 3 antibiotics (amoxicillin, cephalexin, methacyclin) in pregnancy in experimental animals subjected to mild pyridoxine deficiency].
Topics: Animals; Anti-Bacterial Agents; Blood; Body Weight; Female; Fetus; Liver; Pregnancy; Pregnancy Compl | 1975 |
[Effect of methergine, oxytocin, pyridoxine (vitamin B 6) and quinestrol on prolactin and milk secretion in puerperium].
Topics: Female; Humans; Lactation; Methylergonovine; Norpregnatrienes; Oxytocin; Postpartum Period; Pregnanc | 1975 |
Enzymic evaluation of thiamin, riboflavin and pyridoxine status of parturient women and their newborn infants.
Topics: Aspartate Aminotransferases; Erythrocytes; Female; Fetal Blood; Glutathione Reductase; Humans; India | 1976 |
Oral contraceptives and nutrition.
Topics: Ascorbic Acid; Contraceptives, Oral; Contraceptives, Oral, Synthetic; Copper; Family Planning Servic | 1976 |
Influence of different levels of dietary pyridoxine on certain parameters of developing and mature brains in rats.
Topics: Age Factors; Alanine Transaminase; Animals; Birth Weight; Body Weight; Brain; Dose-Response Relation | 1976 |
The influence of pyridoxine on prolactin secretion and milk production in women.
Topics: Adolescent; Adult; Female; Humans; Lactation; Postpartum Period; Pregnancy; Prolactin; Pyridoxine | 1976 |
Prescription drugs in the first trimester and congenital malformations.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Ectromelia; Fe | 1992 |
Aromatic L-amino acid decarboxylase deficiency: clinical features, diagnosis, and treatment of a new inborn error of neurotransmitter amine synthesis.
Topics: Amniotic Fluid; Aromatic-L-Amino-Acid Decarboxylases; Biogenic Amines; Bromocriptine; Cerebrospinal | 1992 |
Risk, statistical inference, and the law of evidence: the use of epidemiological data in toxic tort cases.
Topics: Abnormalities, Drug-Induced; Antiemetics; Confidence Intervals; Data Interpretation, Statistical; Di | 1992 |
Bioavailability of vitamin B-6 in pregnant rats.
Topics: Animals; Biological Availability; Erythrocytes; Female; Intestinal Absorption; Pregnancy; Pregnancy, | 1992 |
Successive pregnancies complicated by idiopathic sideroblastic anemia.
Topics: Adult; Anemia, Sideroblastic; Blood Component Transfusion; Combined Modality Therapy; Female; Humans | 1992 |
Effect of supplementation with folinic acid, vitamin B6, and vitamin B12 on valproic acid-induced teratogenesis in mice.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Drug Interactions; Embryo, Mammalian; | 1992 |
Human placental vitamin B6 (pyridoxal) transport: normal characteristics and effects of ethanol.
Topics: Biological Transport; Biological Transport, Active; Ethanol; Female; Humans; Maternal-Fetal Exchange | 1992 |
Cerebral infarction after caesarean section due to heterozygosity for homocystinuria; a case report.
Topics: Adult; Cerebral Infarction; Cesarean Section; Female; Heterozygote; Homocystinuria; Humans; Pregnanc | 1991 |
Developmental effects of vitamin B-6 restriction on the locomotor behavior of rats.
Topics: Aging; Animals; Circadian Rhythm; Female; Lactation; Male; Maternal-Fetal Exchange; Motor Activity; | 1991 |
[Malnutrition anaemia].
Topics: Adult; Anemia; Child; Child, Preschool; Copper; Dietary Proteins; Digestive System Neoplasms; Female | 1991 |
An antilactogenic effect of pyridoxine.
Topics: Female; Humans; Lactation; Pregnancy; Pyridoxine | 1990 |
Further studies on protective effects of vitamins in cyclophosphamide-induced cleft palate.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cleft Palate; Cyclophosphamide; Female; Fetus; Li | 1990 |
Vitamin B-6 metabolic enzymes in blood and placenta of pregnant mice.
Topics: Alkaline Phosphatase; Animals; Erythrocytes; Female; Hydrogen-Ion Concentration; Intestines; Kidney; | 1990 |
Potential risk factors for brain tumors in children. An analysis of 200 cases.
Topics: Adolescent; Brain Neoplasms; Child; Dicyclomine; Doxylamine; Drug Combinations; Female; Glioma; Huma | 1990 |
Pyridoxine supplementation of lactating mothers: relation to maternal nutrition status and vitamin B-6 concentrations in milk.
Topics: Adult; Colostrum; Female; Fetal Blood; Food, Fortified; Humans; Lactation; Milk, Human; Nutritional | 1990 |
Effects of maternal restriction in vitamin B-6 on neocortex development in rats: neuron differentiation and synaptogenesis.
Topics: Animals; Cell Differentiation; Cerebral Cortex; Dendrites; Diet; Embryonic and Fetal Development; Fe | 1990 |
Drugs in pregnancy.
Topics: Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Hyperemesis Gravidarum; Pregnancy; Pyrid | 1990 |
Vitamin B-6 intakes of lactating women: analyzed vs calculated values.
Topics: Adolescent; Adult; Diet Records; Dietary Proteins; Eating; Energy Intake; Female; Humans; Lactation; | 1990 |
Bendectin--birth defects controversy.
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Extre | 1990 |
Torecan, a review of references and clinical control examinations.
Topics: Adolescent; Child; Drug Evaluation; Female; Humans; Male; Nausea; Pregnancy; Pyridoxine; Thiethylper | 1990 |
Vitamin B1, B2 and B6 in relation to anthropometry, hemoglobin and albumin of newborns and their mothers from northeast Thailand.
Topics: Anthropometry; Body Mass Index; Female; Hemoglobins; Humans; Infant, Low Birth Weight; Infant, Newbo | 1990 |
Key witness against morning sickness drug faces scientific fraud charges.
Topics: Animals; Antiemetics; Australia; Biomedical Research; Dicyclomine; Doxylamine; Drug Combinations; Fe | 1990 |
Pharmacokinetics of doxylamine given as Bendectin in the pregnant monkey and baboon.
Topics: Animals; Chromatography, Gas; Dicyclomine; Doxylamine; Drug Combinations; Female; Half-Life; Macaca | 1989 |
[Neuro- and embryotoxic side effects of vitamin B6].
Topics: Abnormalities, Drug-Induced; Animals; Dose-Response Relationship, Drug; Female; Humans; Infant, Newb | 1989 |
Effect of vitamin B-6 nutrition on the levels of dopamine, dopamine metabolites, dopa decarboxylase activity, tyrosine, and GABA in the developing rat corpus striatum.
Topics: Age Factors; Animals; Aromatic-L-Amino-Acid Decarboxylases; Behavior, Animal; Corpus Striatum; Dopa | 1989 |
Bendectin and human congenital malformations.
Topics: Abnormalities, Drug-Induced; Central Nervous System; Dicyclomine; Digestive System Abnormalities; Do | 1989 |
[Does the vitamin supply of the mother modify the vitamin concentration of the fetus?].
Topics: Birth Weight; Chromatography, High Pressure Liquid; Female; Humans; Infant, Newborn; Maternal-Fetal | 1989 |
Dietary intake of total and glycosylated vitamin B-6 and the vitamin B-6 nutritional status of unsupplemented lactating women and their infants.
Topics: Adult; Breast Feeding; Diet; Female; Glucosides; Humans; Infant; Lactation; Milk, Human; Nutritional | 1989 |
Phocomelia in infant whose mother took large doses of pyridoxine during pregnancy.
Topics: Ectromelia; Female; Humans; Infant; Infant, Newborn; Pregnancy; Pyridoxine | 1985 |
Tropical macrocytic anaemia.
Topics: Anemia, Macrocytic; Female; Humans; India; Pregnancy; Pregnancy Complications, Hematologic; Pyridoxi | 1986 |
The fate of dietary pyridoxine-beta-glucoside in the lactating rat.
Topics: Animals; Animals, Suckling; Chromatography, High Pressure Liquid; Diet; Female; Gastric Mucosa; Gluc | 1989 |
Bendectin and interventricular septal defects.
Topics: Centers for Disease Control and Prevention, U.S.; Dicyclomine; Doxylamine; Drug Combinations; Female | 1985 |
Vitamin B-6 nutriture and plasma diamine oxidase activity in pregnant Hispanic teenagers.
Topics: Adolescent; Alanine Transaminase; Amine Oxidase (Copper-Containing); Female; Hispanic or Latino; Hum | 1986 |
Agenesis of the corpus callosum and neural crest tumors.
Topics: Abdominal Neoplasms; Abnormalities, Drug-Induced; Agenesis of Corpus Callosum; Child; Child, Prescho | 1986 |
Discontinuation of Bendectin.
Topics: Adult; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Pregnancy; P | 1988 |
Factors associated with infantile hypertrophic pyloric stenosis.
Topics: Birth Order; Breast Feeding; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Hypertrophy | 1988 |
Perinatal hypophosphatasia: tissue levels of vitamin B6 are unremarkable despite markedly increased circulating concentrations of pyridoxal-5'-phosphate. Evidence for an ectoenzyme role for tissue-nonspecific alkaline phosphatase.
Topics: Alkaline Phosphatase; Female; Fetal Death; Humans; Hypophosphatasia; Infant, Newborn; Male; Pregnanc | 1988 |
Developmental toxicity evaluation of Bendectin in CD rats.
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylam | 1988 |
Assessment of vitamin B1, B2 and B6 status by coenzyme activation of red cell enzymes using a centrifugal analyser.
Topics: Adult; Aspartate Aminotransferases; Erythrocytes; Female; Glutathione Reductase; Humans; Male; Pregn | 1988 |
Zinc, vitamin B-6, and nutrients.
Topics: Adult; Female; Humans; Nutritional Status; Pregnancy; Pyridoxine; Zinc | 1988 |
The value of case reports in human teratology.
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Eryth | 1986 |
Ritodrine and pyridoxine in herpes gestationis.
Topics: Adult; Female; Humans; Pemphigoid Gestationis; Pregnancy; Pregnancy Complications; Pyridoxine; Ritod | 1986 |
Debendox.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Drug Com | 1986 |
Effects of maternal dietary restriction in vitamin B-6 on neocortex development in rats: B-6 vitamer concentrations, volume and cell estimates.
Topics: Animals; Cell Count; Cerebral Cortex; Female; Lactation; Male; Neurons; Pregnancy; Pregnancy Complic | 1987 |
Treatment of carpal tunnel syndrome with vitamin B6.
Topics: Aspartate Aminotransferases; Carpal Tunnel Syndrome; Electromyography; Female; Humans; Male; Pregnan | 1987 |
A new perspective in the assessment of vitamin B-6 nutritional status during pregnancy in humans.
Topics: Adolescent; Adult; Black People; Female; Humans; Nutritional Status; Pregnancy; Pyridoxal; Pyridoxal | 1987 |
The management of nausea and vomiting during pregnancy.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Legislation, Drug; Nausea; | 1987 |
Limb-reduction deformities and Debendox.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Infant, New | 1987 |
Zinc, vitamin B-6, and other nutrients in pregnant women attending prenatal clinics in Mexico.
Topics: Adult; Body Height; Body Weight; Diet; Female; Humans; Mexico; Pregnancy; Prenatal Care; Pyridoxine; | 1987 |
Vitamin B-6 metabolism in the pregnant rat: effect of progesterone on the (re)distribution in maternal vitamin B-6 stores.
Topics: Animals; Female; Kidney; Liver; Muscles; Organ Size; Ovariectomy; Pregnancy; Pregnancy, Animal; Prog | 1987 |
Effects of pyridoxine on implantation and pregnancy in Wistar rat.
Topics: Animals; Embryo Implantation; Embryonic and Fetal Development; Female; Pregnancy; Pregnancy, Animal; | 1987 |
The weight of the evidence--or--more likely than not.
Topics: Abnormalities, Drug-Induced; Dicyclomine; District of Columbia; Doxylamine; Drug Combinations; Femal | 1986 |
Drugs and stillbirth.
Topics: Abnormalities, Drug-Induced; Adult; Anti-Bacterial Agents; Contraceptives, Oral; Dicyclomine; Doxyla | 1986 |
The natural history of homocystinuria due to cystathionine beta-synthase deficiency.
Topics: Adolescent; Adult; Child; Child, Preschool; Clinical Enzyme Tests; Cystathionine beta-Synthase; Fema | 1985 |
The debendox saga.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 1985 |
Suppression of lactation.
Topics: Australia; Breast Feeding; Bromocriptine; Depression, Chemical; Estrogens; Female; Humans; Lactation | 1986 |
Debendox.
Topics: Abnormalities, Drug-Induced; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combinations | 1986 |
Effects of vitamin B6 intake on nutriture and growth of young infants.
Topics: Body Height; Body Weight; Female; Fetal Blood; Growth; Humans; Infant; Infant Nutritional Physiologi | 1986 |
Relationship between maternal vitamins B2 and B6 status and the levels of these vitamins in milk at different stages of lactation. A study in a low-income group of Indian women.
Topics: Aspartate Aminotransferases; Enzyme Activation; Erythrocytes; Female; Glutathione Reductase; Humans; | 1986 |
Changes in specific nutrients in breast milk during extended lactation.
Topics: Adult; Analysis of Variance; Ascorbic Acid; Calcium; Female; Folic Acid; Humans; Lactation; Magnesiu | 1986 |
Jury clears Bendectin.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Jurispruden | 1985 |
First-trimester drug use and congenital disorders.
Topics: Abnormalities, Drug-Induced; Brompheniramine; Congenital Abnormalities; Dicyclomine; Doxylamine; Dru | 1985 |
Morning sickness and vitamin B6 status of pregnant women.
Topics: Adolescent; Adult; Aspartate Aminotransferases; Erythrocytes; Female; Humans; Nausea; Pregnancy; Pre | 1985 |
[Comparison of vitamin B6 status of gravid and nongravid rats with varying vitamin B6 supplements].
Topics: Animals; Diet; Female; Liver; Muscles; Pregnancy; Pyridoxine; Rats; Rats, Inbred Strains | 1985 |
Congenital heart disease in relation to maternal use of Bendectin and other drugs in early pregnancy.
Topics: Acetaminophen; Adult; Anti-Bacterial Agents; Antiemetics; Aspirin; Dicyclomine; Doxylamine; Drug Com | 1985 |
Suitable alternatives to Debendox for morning sickness in pregnancy.
Topics: Antiemetics; Female; Histamine Antagonists; Humans; Pregnancy; Pregnancy Complications; Pyridoxine | 1985 |
Blame, compensation and birth defects.
Topics: Abnormalities, Drug-Induced; Australia; Congenital Abnormalities; Dicyclomine; Doxylamine; Drug Comb | 1985 |
Debendox revisited.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Drug Com | 1985 |
[Effect of varying vitamin B6 intake levels on the vitamin B6 status of fetuses and reproductive organs].
Topics: Amniotic Fluid; Animals; Birth Weight; Body Weight; Dose-Response Relationship, Drug; Extraembryonic | 1985 |
Vitamin B6, vitamin C and folacin levels in milk from mothers of term and preterm infants during the neonatal period.
Topics: Adult; Ascorbic Acid; Female; Folic Acid; Humans; Infant, Newborn; Infant, Premature; Lactation; Mal | 1985 |
Evaluation of bendectin embryotoxicity in nonhuman primates: I. Ventricular septal defects in prenatal macaques and baboon.
Topics: Animals; Dicyclomine; Dose-Response Relationship, Drug; Doxylamine; Drug Combinations; Female; Fetus | 1985 |
Evaluation of bendectin embryotoxicity in nonhuman primates: II. Double-blind study in term cynomolgus monkeys.
Topics: Animals; Brain; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Method; Doxylamine; Drug | 1985 |
[Teratogenic risk during treatment of Wilson disease].
Topics: Adult; Congenital Abnormalities; Copper; Female; Fetus; Hepatolenticular Degeneration; Humans; Infan | 1985 |
Inter-Regional Epidemiological Study of Childhood Cancer (IRESCC): childhood cancer and the consumption of debendox and related drugs in pregnancy.
Topics: Adolescent; Antiemetics; Child; Cyclohexanecarboxylic Acids; Dicyclomine; Dose-Response Relationship | 1985 |
Nutrition and "the pill".
Topics: Chlormadinone Acetate; Contraceptives, Oral; Demography; Dimethisterone; Ethynodiol Diacetate; Femal | 1971 |
Oral lesions in pregnancy.
Topics: Female; Glossitis; Humans; India; Oral Manifestations; Pregnancy; Pregnancy Complications; Pyridoxin | 1973 |
[Herpes gestationis].
Topics: Dermatitis Herpetiformis; Female; Histamine H1 Antagonists; Humans; Pregnancy; Pregnancy Complicatio | 1972 |
Pellagra-like syndrome associated with isoniazid therapy.
Topics: Adult; Facial Dermatoses; Female; Hand Dermatoses; Humans; Isoniazid; Nicotinic Acids; Pellagra; Pig | 1967 |
Oral contraceptives and depression.
Topics: Contraceptives, Oral; Depression; Female; Humans; Menstruation; Pregnancy; Pyridoxine; Tryptophan | 1969 |
Pyridoxine and the pill.
Topics: Adult; Contraceptives, Oral; Depression; Emotions; Ethynodiol Diacetate; Fatigue; Female; Humans; Ly | 1970 |
[On the vitamin B 6 level of whole blood in pregnant women and female controls after oral administration of a test dose of pyridoxine].
Topics: Female; Humans; Labor, Obstetric; Postpartum Period; Pregnancy; Pyridoxine | 1966 |
The relation of vitamin-B complex to the effect of thalidomide on the sensitivity of intracellular haemoglobin to oxidation.
Topics: Animals; Erythrocytes; Female; Glutethimide; Hemoglobins; Male; Niacinamide; Oxidation-Reduction; Ph | 1967 |
Tryptophan metabolism as affected by anovulatory agents.
Topics: Aminohippuric Acids; Chlorotrianisene; Diethylstilbestrol; Estrogens; Female; Humans; Isoniazid; Kyn | 1969 |
[Dermatological side effects of the so called ovulation inhibitors].
Topics: Adult; Age Factors; Contraceptives, Oral; Drug Eruptions; Female; Humans; Middle Aged; Postpartum Pe | 1971 |
[Specific therapy of extrapyramidal-motor syndromes].
Topics: Analgesics; Athetosis; Chorea; Datura stramonium; Dihydroxyphenylalanine; Dystonia Musculorum Deform | 1969 |
Effect of hyperphenylalaninemia on vitamin B 6 metabolism in developing rat brain.
Topics: Animals; Brain; Carbon Isotopes; Chromatography, Ion Exchange; Female; Fenclonine; Humans; Injection | 1972 |
Effect of vitamin B 6 on phenylalanine metabolism in the brain of normal and p-chlorophenylalanine-treated rats.
Topics: Animals; Brain; Carbon Isotopes; Female; Fenclonine; Humans; Injections, Intraperitoneal; Injections | 1972 |
[Vitamins C, PP and B-6 in the blood and placenta in the developmental dynamics of pregnancy and labor normally and in obstetrical pathology].
Topics: Ascorbic Acid; Blood Chemical Analysis; Female; Humans; Labor, Obstetric; Niacinamide; Obstetric Lab | 1973 |
[Vitamins C, PP and B6 in the blood and placenta in the dynamics of the development of pregnancy and labor normally and in obstetrical pathology].
Topics: Ascorbic Acid; Female; Humans; Labor, Obstetric; Niacinamide; Obstetric Labor Complications; Placent | 1973 |
The effect of hormones and vitamin B6 on urinary excretion of metabolites of the kynurenine pathway.
Topics: Adolescent; Adult; Aged; Androgens; Animals; Estrogens; Female; Humans; Hydrocortisone; Hydrolases; | 1974 |
The effects of intravenously administered water-soluble vitamins during labor in normovitaminemic and hypovitaminemic gravidas on maternal and neonatal blood vitamin levels at delivery.
Topics: Adolescent; Adult; Ascorbic Acid; Avitaminosis; Biotin; Female; Folic Acid; Humans; Infant, Newborn; | 1974 |
[Metoclopramide and hyperemesis gravidarum: a comparative evaluation in four cases].
Topics: Adolescent; Adult; Antiemetics; Female; Humans; Hyperemesis Gravidarum; Parasympatholytics; Pregnanc | 1968 |
Vitamin B 6 enzymes in normal and pre-eclamptic human placentae.
Topics: Alcohol Oxidoreductases; Ammonium Sulfate; Chemical Precipitation; Eclampsia; Female; Humans; Phosph | 1972 |
Teratology and reproduction studies with an antinauseant.
Topics: Abnormalities, Drug-Induced; Animal Feed; Animals; Birth Weight; Female; Histamine H1 Antagonists; M | 1968 |
Studies on the mechanism of induction of tyrosine aminotransferase in neonatal rat liver.
Topics: Adrenal Glands; Adrenalectomy; Animals; Animals, Newborn; Cyclic AMP; Dactinomycin; Depression, Chem | 1969 |
Influence of pyridoxine on tyrosine transaminase activity in maternal and fetal rat liver.
Topics: Adrenal Glands; Adrenalectomy; Age Factors; Animals; Body Weight; Diet; Female; Hydrocortisone; Live | 1970 |
Vitamin B6 nutrition in women with hyperemesis gravidarum during the first trimester of pregnancy.
Topics: Female; Humans; Hyperemesis Gravidarum; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, | 1974 |
Circadian aspects of prostaglandin F2alpha-induced termination of pregnancy.
Topics: Abortion, Induced; Abortion, Therapeutic; Adult; Amniotic Fluid; Circadian Rhythm; Dextropropoxyphen | 1974 |
[Influence of thiamine, riboflavin and vitamin B6 content in food on tissue content of these vitamins in the female lactating rat and young rats].
Topics: Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Body Weight; Diet; Female; La | 1974 |
Iatrogenic nutritional effects of anticonvulsants.
Topics: Adolescent; Adult; Anticonvulsants; Blood Coagulation Disorders; Bone Diseases; Child; Child, Presch | 1974 |
[Vitamin B6-dependency syndrome].
Topics: Asphyxia Neonatorum; Chromosome Aberrations; Chromosome Disorders; Female; Humans; Infant, Newborn; | 1974 |
Interactions of nutrients with oral contraceptives and other drugs.
Topics: Amino Acids; Aminobenzoates; Cell Membrane; Chloramphenicol; Contraceptives, Oral; Digitalis Glycosi | 1973 |
Serotonin deficiency in experimental hyperphenylalaninemia.
Topics: 5-Hydroxytryptophan; Animals; Biphenyl Compounds; Brain; Carbon Radioisotopes; Carboxy-Lyases; Dopa | 1974 |
Herpes gestationis. New immunologic findings.
Topics: Adult; Animals; Antibodies; Basement Membrane; Biopsy; Complement System Proteins; Dermatitis Herpet | 1974 |
[Vitamins. 8. Pyridoxine].
Topics: Adult; Aged; Child; Diet; Female; Food; Food, Fortified; Humans; Infant Food; Infant Nutritional Phy | 1972 |
Cleft palate formation: a role for pyridoxine in the closure of the secondary palate in mice.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Cortisone; Diet; Female; Mice; Palate; Pregnancy | 1972 |
Pyridoxal phosphate and folic acid concentration in blood and erythrocyte aspartate aminotransferase activity during pregnancy.
Topics: Aspartate Aminotransferases; Erythrocytes; Female; Folic Acid; Gestational Age; Humans; Infant, Newb | 1972 |
Herpes gestationis.
Topics: Dermatitis Herpetiformis; Female; Fetal Death; Humans; Prednisolone; Pregnancy; Pregnancy Complicati | 1972 |
[Herpes gestationis. Favorable action of vitamin B 6 ].
Topics: Dermatitis Herpetiformis; Female; Humans; Pregnancy; Pregnancy Complications; Pyridoxine | 1972 |
[Antagonistic interaction between human chorionic gonadotropins and pyridoxine and its significance in pregnancy toxemia].
Topics: Animals; Bufonidae; Cell Movement; Chorionic Gonadotropin; Drug Interactions; Female; Humans; Male; | 1972 |
Cellular growth during prenatal and early postnatal periods in progeny of pyridoxine-deficient rats.
Topics: Animal Nutritional Physiological Phenomena; Animals; Brain; DNA; Embryonic and Fetal Development; Fe | 1973 |
Composition of myelin lipids and synthesis of 3-ketodihydrosphingosine in the vitamin B 6 -deficient developing rat.
Topics: Animals; Animals, Newborn; Body Weight; Brain; Carbon Isotopes; Cerebrosides; Chromatography, Gas; C | 1973 |
Oral contracetpives and vitamin B 6 .
Topics: Contraceptives, Oral; Estrogens; Female; Humans; Pregnancy; Pyridoxine; Transaminases; Tryptophan; V | 1973 |
The vitamin B 6 requirement of the male rat as determined by behavioral patterns, brain pyridoxal phosphate and nucleic acid composition and erythrocyte alanine aminotransferase activity.
Topics: Age Factors; Alanine Transaminase; Animals; Behavior, Animal; Brain; DNA; Dose-Response Relationship | 1973 |
Graded levels of pyridoxine in the rat diet during gestation and the physical and neuromotor development of offspring.
Topics: Age Factors; Animal Nutritional Physiological Phenomena; Animals; Behavior, Animal; Birth Weight; Do | 1973 |
Tissue culture techniques as an aid to prenatal diagnosis and genetic counselling in homocystinuria.
Topics: Adult; Biopsy; Clinical Enzyme Tests; Culture Techniques; Cystathionine; Female; Fibroblasts; Geneti | 1973 |
Pregnancy and homocystinuria.
Topics: Adult; Amnion; Blood Coagulation Tests; Cell Line; Cystine; Female; Fibroblasts; Folic Acid; Homocys | 1973 |
Decreased taurine excretion in relation to childbirth, lactation and progestin-estrogen therapy.
Topics: Contraceptives, Oral; Creatinine; Drug Combinations; Estrogens; Female; Humans; Lactation; Male; Men | 1973 |
B-vitamins in human amniotic fluid.
Topics: Amniocentesis; Amniotic Fluid; Female; Fetal Death; Folic Acid; Humans; Pre-Eclampsia; Pregnancy; Py | 1973 |
Vitamin B6 status in pregnancy.
Topics: Abortion, Spontaneous; Adolescent; Adult; Aspartate Aminotransferases; Birth Weight; Diabetes Mellit | 1973 |
Oral contraceptives, pyridoxine, and depression.
Topics: Animals; Brain Chemistry; Contraceptives, Oral; Depression; Estrogens; Female; Humans; Kynurenine; N | 1973 |
[Influence of thiamine, riboflavin and vitamin B6 diet content in pregnant rats, upon the content of these same vitamins in the maternal and fetal tissues].
Topics: Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Body Composition; Body Weight | 1973 |
Early postnatal changes in brain composition in progeny of rats fed different levels of dietary pyridoxine.
Topics: Animal Nutritional Physiological Phenomena; Animals; Body Weight; Brain; Cerebrosides; Cholesterol; | 1974 |
Behavioral patterns and brain nucleic acid and pyridoxal phosphate contents of male rat progeny from vitamin B-6-repleted dams.
Topics: Animals; Auditory Perception; Behavior, Animal; Brain; DNA; Exploratory Behavior; Female; Gestationa | 1974 |
Delayed maturation of the renal cortex in the vitamin B6-deficient newborn rat.
Topics: Animals; Blood Urea Nitrogen; Body Weight; Brain Chemistry; Cerebral Hemorrhage; Female; Kidney Cort | 1974 |
[Studies on vitamin B6 deficiency during pregnacy and in various pathological states using pyridoxine saturation test].
Topics: Anemia, Hypochromic; Anemia, Macrocytic; Anemia, Pernicious; Bone Marrow Diseases; Diabetes Mellitus | 1968 |
[Blood coagulation and serum lipids in pregnant rats following endotoxin injection--studies of the Sanarelli-Shwartzmann phenomenon].
Topics: Animals; Blood Coagulation; Blood Platelets; Endotoxins; Escherichia coli; Factor V; Female; Fibrino | 1971 |
Tyrosinemia induced by a pyridoxine antagonist, desoxypyridoxine.
Topics: Depression, Chemical; Female; In Vitro Techniques; Lactation; Liver; Liver Cirrhosis; Male; Metaboli | 1972 |
Cerebral lipids and amino acids in the vitamin B 6 -deficient suckling rat.
Topics: Amino Acids; Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Body Weight; Bra | 1972 |
[Amino acid metabolism and mental retardation].
Topics: Diet Therapy; Female; Homocystinuria; Humans; Intellectual Disability; Intelligence; Male; Methionin | 1972 |
Effects of dietary vitamin B 6 on the utilization of monosodium glutamate by rats.
Topics: Aging; Alanine; Alanine Transaminase; Animals; Animals, Newborn; Aspartate Aminotransferases; Aspart | 1972 |
[Familial pyridoxine deficiency in a diabetic patient and her children. Infantile myoclonic encephalopathy with hypsarrhythmia cured with vitamin B 6 in one of them].
Topics: Adult; Electroencephalography; Female; Humans; Infant; Infant, Newborn; Male; Pregnancy; Pregnancy i | 1972 |
[Influence of the non-specific pharmacodynamic action of some vitamins of the B group with a metabolizing role on the reactivity of the genital tract and evolution of the sexual cycle].
Topics: Animals; Estrus; Female; Genitalia, Female; Pregnancy; Pyridoxine; Rats; Thiamine | 1972 |
Regarding 4-pyridoxic acid-5'-phosphate in animal tissue.
Topics: Animals; Carboxylic Acids; Chromatography; Chromatography, Thin Layer; Female; Liver; Male; Mice; Mi | 1972 |
[Development during pregnancy and lactation vitamin content of rat tissues (thiamine, riboflavin, nicotinic acid and vitamin B 6 ].
Topics: Animals; Body Weight; Female; Fetus; Kidney; Lactation; Liver; Nicotinic Acids; Organ Size; Pregnanc | 1972 |
Methionine load test in pyridoxine deficiency.
Topics: Aspartate Aminotransferases; Cystathionine; Cysteine; Erythrocytes; Female; Humans; Hydro-Lyases; Me | 1972 |
Erythrocyte glutamic oxaloacetic transaminase activity in patients with oral lesions.
Topics: Aspartate Aminotransferases; Cheilitis; Erythrocytes; Female; Glossitis; Humans; Male; Metabolism; M | 1971 |
Metabolism of [14C] pyridoxol in the pregnant rat.
Topics: Animals; Brain Chemistry; Carbon Isotopes; Cellulose; Chromatography; Female; Fetus; Kidney; Liver; | 1971 |
[Convulsions caused by vitamin B-6 dependence in the newborn infant. Review of the subject and report of 2 clinical cases].
Topics: Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Metabolism, Inborn Errors; Pregn | 1971 |
[Treatment of chloasma caused by oral contraceptives by a vitamin B complex. Preliminary note].
Topics: Contraceptives, Oral; Female; Humans; Pigmentation Disorders; Pregnancy; Pyridoxine; Skin Manifestat | 1971 |
[Changes in genital tract reactivity and evolution of the sexual cycle following prolonged administration of pyridoxine].
Topics: Animals; Estrus; Female; Genitalia, Female; Injections; Ovary; Pregnancy; Pyridoxine; Rats; Uterus; | 1971 |
Abnormal pyridoxine metabolism in toxemia of pregnancy.
Topics: Brain; Brain Chemistry; Female; Humans; Kidney; Liver; Phosphotransferases; Placenta; Pre-Eclampsia; | 1969 |
Effect of vitamin B 6 on blood 5-hydroxytryptamine concentration.
Topics: Animals; Animals, Newborn; Birth Weight; Body Weight; Brain; Carboxy-Lyases; Desoxycorticosterone; D | 1969 |
[Vitamins and pregnancy].
Topics: Abortion, Spontaneous; Anemia, Hemolytic, Congenital; Animals; Ascorbic Acid; Ergocalciferols; Femal | 1967 |
[Evaluation of a combination of antiemetics in cases of nausea and vomiting during pregnancy].
Topics: Adolescent; Adult; Antiemetics; Cyclohexanecarboxylic Acids; Female; Humans; Nausea; Pre-Eclampsia; | 1968 |
[Changes in blood vitamin A, D, B1, B2, B6, C content and their urinary excretion in pregnant women].
Topics: Ascorbic Acid; Biotin; Female; Humans; Pregnancy; Pyridoxine; Riboflavin; Thiamine; Vitamin A; Vitam | 1969 |
[Seizures in newborn infants].
Topics: Birth Injuries; Cerebral Hemorrhage; Diazepam; Female; Glucose; Humans; Hypernatremia; Hypoglycemia; | 1969 |
Blood and urine levels of vitamin B6 in the mother and fetus before and after loading of the mother with vitamin B6.
Topics: Adult; Female; Humans; Infant, Newborn; Injections, Intravenous; Intestinal Absorption; Male; Matern | 1970 |
Teratogenicity of vitamin B6 deficiency: omphalocele, skeletal and neural defects, and splenic hypoplasia.
Topics: Animals; Brain; Cleft Palate; Disease Models, Animal; Female; Hernia, Ventral; Limb Deformities, Con | 1970 |
Hydrazine toxicity in pregnant rats.
Topics: Animals; Body Weight; Embryonic and Fetal Development; Female; Fetal Death; Fetus; Gestational Age; | 1970 |
4-pyridoxic acid 5'-phosphate: a metabolite of pyridoxol in the rat.
Topics: Animals; Carbon Isotopes; Chromatography; Chromatography, DEAE-Cellulose; Chromatography, Thin Layer | 1970 |
[Therapy of eclampsia].
Topics: Amino Acids; Eclampsia; Female; Heparin; Humans; Magnesium; Microcirculation; Pregnancy; Pyridoxine | 1970 |
[Vitamin-B6-dependent pediatric diseases. Hereditary pyridoxine-dependent spasms in newborns and xanthurenuria in parents].
Topics: Adult; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Metabolism, Inborn Errors; Pregna | 1970 |
Alanine aminotransferase activity in liver and erythrocytes of pregnant and nonpregnant rats fed different levels of pyridoxine.
Topics: Alanine Transaminase; Animals; Body Weight; Caseins; Diet; Erythrocytes; Female; Liver; Nutritional | 1971 |
Oral contraceptives and vitamin B6 metabolism.
Topics: Adult; Alanine Transaminase; Amino Acids; Aspartate Aminotransferases; Contraceptives, Oral; Diet; E | 1971 |
Tuberculous meningitis and pregnancy.
Topics: Adult; Aminosalicylic Acids; Electroencephalography; Female; Humans; Injections, Intramuscular; Ison | 1971 |
The cellular approach to the determination of pyridoxine requirements in pregnant and nonpregnant rats.
Topics: Alanine Transaminase; Amino Acids; Animals; Brain; Carbon Isotopes; Cell-Free System; Diet; DNA; Fem | 1971 |
Abnormal tryptophan metabolism in pregnancy and with the oral contraceptive pill. II. Relative levels of vitamin B 6-vitamers in cord and maternal blood.
Topics: Blood; Contraceptives, Oral; Erythrocytes; Female; Humans; Maternal-Fetal Exchange; Pregnancy; Pregn | 1971 |
[Hyperemesis in the first trimester of pregnancy: causes and therapeutic advances].
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Adult; Chlorpromazine; Female; Humans; Hyperem | 1967 |
[On the treatment of hyperemesis gravidarum. Clinical case studies].
Topics: Adult; Female; Humans; Hyperemesis Gravidarum; Pregnancy; Pregnancy Complications; Pyridoxine; Thiam | 1967 |
[Research on avitaminosis B6 with the aid of a pyridoxine loading test].
Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Maternal-Fetal Exchange; Pregnancy | 1968 |
[Delivery mechanism and 5-hydroxytryptamine].
Topics: Adult; Animals; Female; Humans; Labor, Obstetric; Placenta; Pregnancy; Pyridoxine; Rats; Serotonin; | 1968 |
[On the influence of ovulation inhibitors on tryptophan metabolism in relation to vitamin B6].
Topics: Adult; Contraceptives, Oral; Female; Gestational Age; Humans; Kynurenic Acid; Kynurenine; Pregnancy; | 1968 |
[Investigations into the polymorphism of acetylation of isonicotinic acid hydrazid (INH)].
Topics: Asian People; Female; Genetics, Population; Humans; Isoniazid; Polymorphism, Genetic; Polyneuropathi | 1968 |
[Experimental studies in a case of tyrosinosis. New pathogenic hypothesis].
Topics: Adult; Amino Acids; Animals; Blood Glucose; Carbon Dioxide; Chromatography; Depression, Chemical; Di | 1969 |
[Pyridoxine in the treatment of early pregnancy toxemias. II. Theoretical contribution to the mechanism of action of vitamin B 6].
Topics: Adult; Female; Gastric Juice; Gestational Age; Humans; Hyperemesis Gravidarum; Hypothalamo-Hypophyse | 1969 |
[Pyridoxine in the treatment of early pregnancy toxemia. I. Change of gastric secretion under the effect of vitamin B 6 controlled by Acidotest].
Topics: Adult; Female; Gastric Acidity Determination; Gastric Juice; Humans; Hyperemesis Gravidarum; Pregnan | 1969 |
[Excretion of pyridoxic acid in newborns with its modification by pyridoxine loading].
Topics: Aspartate Aminotransferases; Erythrocytes; Female; Humans; Infant; Infant, Newborn; Isonicotinic Aci | 1969 |
[Hyperemesis gravidarum as an obstetrical problem. Its treatment with fluphenazine and pyridoxine].
Topics: Adult; Female; Fluphenazine; Humans; Hyperemesis Gravidarum; Pregnancy; Pyridoxine | 1965 |
The metabolism of 5-hydroxytryptamine (serotonin) in the newborn.
Topics: Animals; Animals, Newborn; Birth Weight; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy, Anim | 1965 |
Assessment of vitamin B6 nutriture in pregnancy in the rat.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Erythrocytes; Female; Liver; Pregnancy; | 1965 |
Abnormal pyridoxine metabolism in toxemia of pregnancy.
Topics: Female; Humans; Kidney; Phosphorylase Kinase; Placenta; Pre-Eclampsia; Pregnancy; Pyridoxine; Trypto | 1966 |
Effect of maternal pyridoxine ingestion on cord blood 5-hydroxytryptamine concentration.
Topics: Blood; Female; Humans; Hydroxyindoleacetic Acid; Infant, Newborn; Male; Maternal-Fetal Exchange; Pre | 1966 |
[Research on the direct measurement of vitamin B 6 in the blood of pregnant women].
Topics: Female; Humans; Pregnancy; Pregnancy Complications; Pyridoxine; Vitamin B Deficiency | 1966 |