Page last updated: 2024-10-20

pyridoxine and Poisoning

pyridoxine has been researched along with Poisoning in 32 studies

4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).

Poisoning: Used with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure.

Research Excerpts

ExcerptRelevanceReference
"Isoniazid toxicity from self-poisoning or dosing errors remains common in regions of the world where tuberculosis is prevalent."9.12Extracorporeal treatments for isoniazid poisoning: Systematic review and recommendations from the EXTRIP workgroup. ( Ghannoum, M; Gosselin, S; Hoffman, RS; Kielstein, JT; Lavergne, V; Mowry, JB; Nolin, TD; Roberts, DM; Shepherd, G; Vijayan, A, 2021)
"Isoniazid toxicity from self-poisoning or dosing errors remains common in regions of the world where tuberculosis is prevalent."5.12Extracorporeal treatments for isoniazid poisoning: Systematic review and recommendations from the EXTRIP workgroup. ( Ghannoum, M; Gosselin, S; Hoffman, RS; Kielstein, JT; Lavergne, V; Mowry, JB; Nolin, TD; Roberts, DM; Shepherd, G; Vijayan, A, 2021)
" Pyridoxine has been used as an antidote in acute intoxications, including isoniazid overdose, Gyromitra mushroom or false morrel (monomethylhydrazine) poisoning and hydrazine exposure."4.82Pyridoxine in clinical toxicology: a review. ( Gris, M; Lheureux, P; Penaloza, A, 2005)
"Over the past 10 years the reported incidence of acute isoniazid (INH)-related poisonings has increased, with 507 cases reported in 1996."3.70Acute isoniazid exposures and antidote availability. ( Linakis, JG; Santucci, KA; Shah, BR, 1999)
"One patient presented twice with seizures."1.29Acute isoniazid neurotoxicity in an urban hospital. ( Santucci, K; Shah, BR; Sinert, R; Steiner, P, 1995)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-199021 (65.63)18.7374
1990's5 (15.63)18.2507
2000's4 (12.50)29.6817
2010's1 (3.13)24.3611
2020's1 (3.13)2.80

Authors

AuthorsStudies
Mowry, JB1
Shepherd, G1
Hoffman, RS1
Lavergne, V1
Gosselin, S1
Nolin, TD1
Vijayan, A1
Kielstein, JT1
Roberts, DM1
Ghannoum, M1
Schmid, DR1
Lee, JA1
Wismer, TA1
Diniz, PPVP1
Murtaugh, RJ1
Makarovsky, I1
Markel, G1
Dushnitsky, T1
Eisenkraft, A1
Burda, AM1
Sigg, T1
Wahl, M1
SIGWALD, J1
BOUTTIER, D1
GUIBERT, J1
NICOLAS-CHARLES, PJ1
ZARA, M1
WAREMBOURG, H1
NIQUET, G1
DUCLOUX, G1
STALNIKIEWICZ, G1
PERRARD, C1
BERTRAND, M1
FRIERSON, WB1
Lheureux, P1
Penaloza, A1
Gris, M1
Chan, CK1
Chan, YC1
Litovitz, TL1
Shah, BR2
Santucci, K1
Sinert, R1
Steiner, P1
Marcovigi, P1
Valtancoli, E1
Calbi, P1
Farolfi, P1
Calbi, G1
Lewin, PK1
McGreal, D1
Santucci, KA1
Linakis, JG1
Kirklin, JK1
Watson, M1
Bondoc, CC1
Burke, JF1
Sievers, ML1
Herrier, RN1
Cash, JM1
Zawada, ET1
Boehnert, MT1
Lewander, WJ1
Gaudreault, P1
Lovejoy, FH1
Lange, PG1
Moores, K1
Mul'menko, AM1
Martsinkevich, GA1
Meadow, SR2
Lewkowski, W1
Maciejek, Z1
Leeson, GA1
Cotzias, GC2
Papavasiliou, PS1
Ginos, J1
Steck, A1
Düby, S1
Brown, CV1
Friedman, SA1
Katz, GA2
Jobin, GC2
Lall, KB1
Saxena, S1
Mehta, JB1
An, AS1
D'iachenko, VA1
Ivanov, VI1
Talin, AP1

Reviews

5 reviews available for pyridoxine and Poisoning

ArticleYear
Extracorporeal treatments for isoniazid poisoning: Systematic review and recommendations from the EXTRIP workgroup.
    Pharmacotherapy, 2021, Volume: 41, Issue:5

    Topics: Animals; Humans; Isoniazid; Poisoning; Practice Guidelines as Topic; Pyridoxine; Renal Dialysis

2021
Pyridoxine in clinical toxicology: a review.
    European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2005, Volume: 12, Issue:2

    Topics: Animals; Antidotes; Ethanol; Ethylene Glycol; Humans; Hydrazines; Isoniazid; Mushroom Poisoning; Poi

2005
The anecdotal antidotes.
    Emergency medicine clinics of North America, 1984, Volume: 2, Issue:1

    Topics: Acetylcysteine; Adult; Aged; Animals; Antidotes; Child; Cimetidine; Female; Ferrocyanides; Folic Aci

1984
Advances in clinical toxicology.
    Pediatric clinics of North America, 1985, Volume: 32, Issue:1

    Topics: Antidotes; Cathartics; Charcoal; Child; Cocaine; Deglutition; Foreign Bodies; Gastric Lavage; Humans

1985
Metabolic modification of Parkinson's disease and of chronic manganese poisoning.
    Annual review of medicine, 1971, Volume: 22

    Topics: Animals; Brain; Choline; Chronic Disease; Dihydroxyphenylalanine; Drug Synergism; Humans; Manganese

1971

Other Studies

27 other studies available for pyridoxine and Poisoning

ArticleYear
Isoniazid toxicosis in dogs: 137 cases (2004-2014).
    Journal of the American Veterinary Medical Association, 2017, Sep-15, Volume: 251, Issue:6

    Topics: Animals; Antitubercular Agents; Dog Diseases; Dogs; Female; Isoniazid; Male; Poisoning; Pyridoxine;

2017
Hydrazine--the space era agent.
    The Israel Medical Association journal : IMAJ, 2008, Volume: 10, Issue:4

    Topics: Accidents, Traffic; Animals; Antidotes; Carcinogens; Chemical Terrorism; Humans; Hydrazines; Poisoni

2008
Possible adverse reactions to preservatives in high-dose pyridoxine hydrochloride i.v. injection.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2002, Oct-01, Volume: 59, Issue:19

    Topics: Antidotes; Dose-Response Relationship, Drug; Humans; Injections, Intravenous; Isoniazid; Poisoning;

2002
[Acute methyl bromide poisoning; rapid improvement in the sequellae, following massive doses of pyridoxine].
    Revue neurologique, 1955, Volume: 92, Issue:4

    Topics: Bromides; Humans; Hydrocarbons, Brominated; Hypnotics and Sedatives; Poisoning; Pyridoxine; Vitamin

1955
[A NEW DETOXICANT: PYRIDOSCORBINE].
    Gazette medicale de France, 1964, Feb-25, Volume: 71

    Topics: Ascorbic Acid; Mice; Poisoning; Pyridoxine; Research; Toxicology

1964
[ANURIA FROM ABSORPTION OF MASSIVE DOSES OF ISONIAZIDE. ARTIFICIAL KIDNEY. RECOVERY].
    Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille, 1964, Volume: 9

    Topics: Anuria; Isoniazid; Kidney; Kidneys, Artificial; Physiological Phenomena; Poisoning; Pyridoxine; Suic

1964
USE OF PYRIDOXINE HCL IN ACUTE HYDRAZINE AND UDMH INTOXICATION.
    Industrial medicine & surgery, 1965, Volume: 34

    Topics: Drug Therapy; Humans; Hydrazines; Neurologic Manifestations; Poisoning; Pyridoxine; Toxicology

1965
Antidotes for tetramine poisoning.
    Hong Kong medical journal = Xianggang yi xue za zhi, 2006, Volume: 12, Issue:1

    Topics: Antidotes; Bridged-Ring Compounds; Humans; Poisoning; Pyridoxine; Rodenticides; Unithiol

2006
Acute isoniazid neurotoxicity in an urban hospital.
    Pediatrics, 1995, Volume: 95, Issue:5

    Topics: Acute Disease; Adolescent; Child; Female; Humans; Infant, Newborn; Infusions, Intravenous; Isoniazid

1995
[Pyridoxine administration in acute isoniazid intoxication].
    Minerva pediatrica, 1993, Volume: 45, Issue:9

    Topics: Acidosis; Blood Gas Analysis; Child, Preschool; Coma; Female; Gastric Lavage; Humans; Isoniazid; Poi

1993
Isoniazid toxicity with cerebellar ataxia in a child.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1993, Jan-01, Volume: 148, Issue:1

    Topics: Cerebellar Ataxia; Child; Female; Humans; Isoniazid; Poisoning; Pyridoxine

1993
Acute isoniazid exposures and antidote availability.
    Pediatric emergency care, 1999, Volume: 15, Issue:2

    Topics: Acute Disease; Antidotes; Antitubercular Agents; Child; Drug Storage; Emergency Medicine; Emergency

1999
Treatment of hydrazine-induced coma with pyridoxine.
    The New England journal of medicine, 1976, Apr-22, Volume: 294, Issue:17

    Topics: Accidents, Occupational; Adult; Burns, Chemical; Coma; Humans; Hydrazines; Injections, Intramuscular

1976
Treatment of acute isoniazid toxicity.
    American journal of hospital pharmacy, 1975, Volume: 32, Issue:2

    Topics: Acidosis; Adolescent; Adult; Airway Obstruction; Anticonvulsants; Bicarbonates; Coma; Diuresis; Fema

1975
Isoniazid overdose. Successful treatment with pyridoxine and hemodialysis.
    The Western journal of medicine, 1991, Volume: 155, Issue:6

    Topics: Adolescent; Drug Overdose; Humans; Isoniazid; Male; Poisoning; Pyridoxine; Renal Dialysis

1991
Antidotes in the treatment of acute poisoning.
    Iowa medicine : journal of the Iowa Medical Society, 1987, Volume: 77, Issue:8

    Topics: Acetylcysteine; Antidotes; Digoxin; Ethanol; Glucagon; Humans; Immunoglobulin Fab Fragments; Methyle

1987
[Vitamin PP and B6 metabolism in experimental trotyl poisoning].
    Gigiena truda i professional'nye zabolevaniia, 1973, Volume: 17, Issue:12

    Topics: Animals; Male; Niacinamide; Poisoning; Pyridoxine; Rats; Time Factors; Trinitrotoluene

1973
Poisoning from delayed release tablets.
    British medical journal, 1972, Feb-19, Volume: 1, Issue:5798

    Topics: Delayed-Action Preparations; Histamine H1 Antagonists; Humans; Infant; Male; Parasympatholytics; Poi

1972
[Acute poisoning with isonicotinic acid hydrazide].
    Gruzlica i choroby pluc; tuberculosis et pneumonologia, 1973, Volume: 41, Issue:3

    Topics: Acute Disease; Adolescent; Adult; Aged; Blood Transfusion; Bloodletting; Child; Female; Gastric Lava

1973
Poisoning with delayed-release tablets. Treatment of Debendox poisoning with purgation and dialysis.
    Archives of disease in childhood, 1974, Volume: 49, Issue:4

    Topics: Body Fluids; Cathartics; Cyclohexanecarboxylic Acids; Delayed-Action Preparations; Diazepam; Drug Co

1974
Acute isoniazid poisoning.
    The American review of respiratory disease, 1972, Volume: 105, Issue:2

    Topics: Acidosis; Acute Disease; Adolescent; Adult; Aged; Alaska; Antidotes; Carbon Dioxide; Child; Child, P

1972
Death following massive ingestion of isoniazid.
    The American review of respiratory disease, 1969, Volume: 100, Issue:6

    Topics: Acidosis; Adolescent; Anticonvulsants; Coma; Fever; Gastric Lavage; Humans; Intubation, Intratrachea

1969
Metabolic modification of some neurologic disorders.
    JAMA, 1969, Nov-17, Volume: 210, Issue:7

    Topics: Dihydroxyphenylalanine; Dopamine; Humans; Male; Manganese; Manganese Poisoning; Parkinson Disease; P

1969
Large doses of pyridoxine in the treatment of massive ingestion of isoniazid.
    The American review of respiratory disease, 1970, Volume: 101, Issue:6

    Topics: Adolescent; Adult; Humans; Isoniazid; Male; Poisoning; Pyridoxine

1970
Chemoprophylaxis of tuberculosis.
    The New England journal of medicine, 1970, May-21, Volume: 282, Issue:21

    Topics: Alaska; Humans; Isoniazid; Poisoning; Pyridoxine; Tuberculosis

1970
Acute isoniazid intoxication. (A case report).
    Indian pediatrics, 1970, Volume: 7, Issue:4

    Topics: Child, Preschool; Humans; Isoniazid; Male; Poisoning; Pyridoxine

1970
[Experience in the prevention by drugs of nervous system lesions in poisoning with fire-proof oil "Ivviol'-3'].
    Gigiena truda i professional'nye zabolevaniia, 1970, Volume: 14, Issue:12

    Topics: Accidents, Occupational; Female; Humans; Lubrication; Male; Nervous System Diseases; Oils; Poisoning

1970