Page last updated: 2024-10-20

pyridoxine and Phenylketonurias

pyridoxine has been researched along with Phenylketonurias in 25 studies

4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).

Phenylketonurias: A group of autosomal recessive disorders marked by a deficiency of the hepatic enzyme PHENYLALANINE HYDROXYLASE or less frequently by reduced activity of DIHYDROPTERIDINE REDUCTASE (i.e., atypical phenylketonuria). Classical phenylketonuria is caused by a severe deficiency of phenylalanine hydroxylase and presents in infancy with developmental delay; SEIZURES; skin HYPOPIGMENTATION; ECZEMA; and demyelination in the central nervous system. (From Adams et al., Principles of Neurology, 6th ed, p952).

Research

Studies (25)

Timeframe	Studies, this research(%)	All Research%
pre-1990	22 (88.00)	18.7374
1990's	2 (8.00)	18.2507
2000's	1 (4.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
McGEER, EG	1
TISCHLER, B	1
CHRISTIAENS, L	1
GAUDIER, B	1
BRIET, B	1
COCHRANE, WA	1
SEGNI, G	1
GANDULLIA, E	1
PESCETTO, T	1
Bhat, M	1
Haase, C	1
Lee, PJ	1
Loo, YH	5
Ritman, P	1
Whittaker, VP	1
Vorhees, CV	1
Butcher, RE	1
Berry, HK	1
Prince, AP	1
Leklem, JE	1
Snyderman, SE	1
Iinuma, K	1
Borkowska, I	1
Surtees, R	1
Hyland, K	1
Kennedy, B	1
Anderson, K	1
Acosta, PB	1
Holtzman, NA	1
Coburn, SP	1
Seidenberg, M	1
Mack, K	2
Shaw, KN	1
Lieberman, E	1
Koch, R	1
Donnell, GN	1
Hagge, W	1
Machill, G	1
Haufe, U	1
Haufe, F	1
Lubs, H	1
Berman, JL	1
Justice, P	1
Hsia, DY	1
Heeley, AF	1

Reviews

3 reviews available for pyridoxine and Phenylketonurias

Article	Year
Progress in experimental phenylketonuria: a critical review. Neuroscience and biobehavioral reviews, 1981,Spring, Volume: 5, Issue:1 Topics: Abnormalities, Multiple; Animals; Disease Models, Animal; Energy Metabolism; Female; Fenclonine; Glu	1981
The dietary therapy of inherited metabolic disease. Progress in food & nutrition science, 1975, Volume: 1, Issue:7-8 Topics: Alkaptonuria; Amino Acid Metabolism, Inborn Errors; Carbohydrate Metabolism, Inborn Errors; Child; C	1975
Dietary treatment of inborn errors of metabolism. Annual review of medicine, 1970, Volume: 21 Topics: Ammonia; Carbohydrate Metabolism, Inborn Errors; Diet Therapy; Female; Fructose; Galactosemias; Glyc	1970

Other Studies

22 other studies available for pyridoxine and Phenylketonurias

Article	Year
Vitamin B6 and mental deficiency; the effects of large doses of B6 (pyridoxine) in phenylketonuria. Canadian journal of biochemistry and physiology, 1959, Volume: 37, Issue:3 Topics: Humans; Intellectual Disability; Phenylketonurias; Pyridoxine; Vitamin B 6	1959
[PHENYLKETONURIA. APROPOS OF A FAMILIAL CASE]. Pediatrie, 1963, Volume: 18 Topics: Blood Chemical Analysis; Body Fluids; Diet; Diet Therapy; Electroencephalography; Genetics, Medical;	1963
NUTRITION RESEARCH IN PAEDIATRICS. Canadian hospital, 1964, Volume: 41 Topics: Canada; Child; Diet; Diet Therapy; Epilepsy; Epilepsy, Absence; Humans; Infant; Infant Nutritional P	1964
[RELATIONSHIP BETWEEN METABOLISM OF TRYPTOPHAN AND PYRIDOXIN IN PHENYLKETONURIA]. Minerva pediatrica, 1965, Feb-11, Volume: 17 Topics: Humans; Metabolism; Phenylketonurias; Pyridoxine; Tryptophan	1965
Social outcome in treated individuals with inherited metabolic disorders: UK study. Journal of inherited metabolic disease, 2005, Volume: 28, Issue:6 Topics: Adolescent; Adult; Aged; Child; Employment; Female; Follow-Up Studies; Galactosemias; Homocystinuria	2005
Phenylketonuria and vitamin B6 function. Nature, 1967, Mar-04, Volume: 213, Issue:5079 Topics: Acrodynia; Alopecia; Animals; Behavior, Animal; Body Weight; Diet; Growth; Humans; Learning; Male; P	1967
Pyridoxal kinase in brain and its inhibition by pyridoxylidene-beta-phenylethylamine. Journal of neurochemistry, 1967, Volume: 14, Issue:10 Topics: Animals; Brain; Cerebral Cortex; Guinea Pigs; Humans; Imines; In Vitro Techniques; Phenethylamines;	1967
Vitamin B-6 status of school-aged patients with phenylketonuria. The American journal of clinical nutrition, 1994, Volume: 60, Issue:2 Topics: Adolescent; Alkaline Phosphatase; Child; Diet; Dietary Proteins; Female; Humans; Male; Phenylalanine	1994
[Convulsive disorders in inborn errors of metabolism (author's transl)]. No to shinkei = Brain and nerve, 1979, Volume: 31, Issue:5 Topics: Electroencephalography; Gangliosidoses; Homocystinuria; Humans; Metabolism, Inborn Errors; Phenylket	1979
[Metabolism of amino acids and brain proteins in phenylketonuria]. Postepy biochemii, 1979, Volume: 25, Issue:2 Topics: Animals; Brain; Catecholamines; Chemical Phenomena; Chemistry; Glycolysis; Humans; Nerve Tissue Prot	1979
L-3,4-dihydroxyphenylalanine (levodopa) lowers central nervous system S-adenosylmethionine concentrations in humans. Journal of neurology, neurosurgery, and psychiatry, 1990, Volume: 53, Issue:7 Topics: Adolescent; Akinetic Mutism; Biopterins; Child, Preschool; Humans; Infant; Levodopa; Methionine; NAD	1990
Nutrition support of inborn errors of amino acid metabolism. International journal of bio-medical computing, 1985, Volume: 17, Issue:1 Topics: Amino Acid Metabolism, Inborn Errors; Computers; Drug Resistance; Homocystinuria; Humans; Infant; In	1985
Leukocyte pyridoxal phosphate and alkaline phosphatase in Down's syndrome and other retardates. The American journal of clinical nutrition, 1969, Volume: 22, Issue:9 Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aldehydes; Alkaline Phosphatase; Body Surface Area; Depr	1969
Effect of hyperphenylalaninemia on vitamin B 6 metabolism in developing rat brain. Journal of neurochemistry, 1972, Volume: 19, Issue:10 Topics: Animals; Brain; Carbon Isotopes; Chromatography, Ion Exchange; Female; Fenclonine; Humans; Injection	1972
Effect of vitamin B 6 on phenylalanine metabolism in the brain of normal and p-chlorophenylalanine-treated rats. Journal of neurochemistry, 1972, Volume: 19, Issue:10 Topics: Animals; Brain; Carbon Isotopes; Female; Fenclonine; Humans; Injections, Intraperitoneal; Injections	1972
Cystathioninuria. American journal of diseases of children (1960), 1967, Volume: 113, Issue:1 Topics: Adult; Amino Acid Metabolism, Inborn Errors; Amino Acids; Carcinoma, Hepatocellular; Child, Preschoo	1967
Serotonin deficiency in experimental hyperphenylalaninemia. Journal of neurochemistry, 1974, Volume: 23, Issue:1 Topics: 5-Hydroxytryptophan; Animals; Biphenyl Compounds; Brain; Carbon Radioisotopes; Carboxy-Lyases; Dopa	1974
[Amino acid metabolism and mental retardation]. Die Medizinische Welt, 1972, Apr-15, Volume: 23, Issue:16 Topics: Diet Therapy; Female; Homocystinuria; Humans; Intellectual Disability; Intelligence; Male; Methionin	1972
[Kynureninase activity and pyridoxine elimination in rats with experimental phenylketonuria]. Acta biologica et medica Germanica, 1971, Volume: 26, Issue:3 Topics: Animals; Disease Models, Animal; Humans; Hydrolases; Kynurenine; Liver; Phenylketonurias; Pyridoxine	1971
Effect of vitamin B 6 on blood 5-hydroxytryptamine concentration. Annals of the New York Academy of Sciences, 1969, Sep-30, Volume: 166, Issue:1 Topics: Animals; Animals, Newborn; Birth Weight; Body Weight; Brain; Carboxy-Lyases; Desoxycorticosterone; D	1969
The effect of pyridoxine on tryptophan metabolism in phenylketonuria. Clinical science, 1965, Volume: 29, Issue:3 Topics: Child; Child, Preschool; Chromatography, Ion Exchange; Diet Therapy; Humans; In Vitro Techniques; In	1965
Pyridoxine and phenylketonuria. JAMA, 1966, Apr-25, Volume: 196, Issue:4 Topics: Humans; Phenylketonurias; Pyridoxine; Tryptophan	1966