Page last updated: 2024-10-20

pyridoxine and Parkinson Disease

pyridoxine has been researched along with Parkinson Disease in 80 studies

4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).

Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)

Research Excerpts

ExcerptRelevanceReference
"To reduce the side effects in the medication of Parkinson and Asthma, pyridoxine (PY) is administered along with l-3,4-dihydroxyphenyl alanine (l-dopa) and theophylline (TP), respectively."7.83Highly sensitive interference-free electrochemical determination of pyridoxine at graphene modified electrode: Importance in Parkinson and Asthma treatments. ( Gowthaman, NS; John, SA; Raj, MA, 2016)
"VB6 deficiency anemia is typically microcytic, hypochromic, and sideroblastic."5.72Vitamin B6 Deficiency Anemia Attributed to Levodopa/Carbidopa Intestinal Gel Therapy for Parkinson's Disease: A Diagnostic Pitfall for Myelodysplastic Syndrome with Ring Sideroblasts. ( Ando, M; Hatano, T; Hattori, N; Honda, T; Komatsu, N; Tsutsui, M; Yasuda, H, 2022)
"To reduce the side effects in the medication of Parkinson and Asthma, pyridoxine (PY) is administered along with l-3,4-dihydroxyphenyl alanine (l-dopa) and theophylline (TP), respectively."3.83Highly sensitive interference-free electrochemical determination of pyridoxine at graphene modified electrode: Importance in Parkinson and Asthma treatments. ( Gowthaman, NS; John, SA; Raj, MA, 2016)
" This review summarises that available pharmacokinetic data involving levodopa, especially as it relates to therapeutic response of parkinsonian patients."2.35Clinical pharmacokinetics of levodopa in parkinson's disease. ( Bianchine, JR; Shaw, GM, 1976)
"VB6 deficiency anemia is typically microcytic, hypochromic, and sideroblastic."1.72Vitamin B6 Deficiency Anemia Attributed to Levodopa/Carbidopa Intestinal Gel Therapy for Parkinson's Disease: A Diagnostic Pitfall for Myelodysplastic Syndrome with Ring Sideroblasts. ( Ando, M; Hatano, T; Hattori, N; Honda, T; Komatsu, N; Tsutsui, M; Yasuda, H, 2022)
"Pyridoxine metabolism was investigated in eight chronic levodopa-treated parkinsonian patients and in eight matched dopa-naive controls by measurement of plasma and erythrocyte pyridoxal-5-phosphate concentrations over a 24-hour period, following intravenous administration of pyridoxine."1.25Effect of chronic levodopa treatment on pyridoxine metabolism. ( Mars, H, 1975)

Research

Studies (80)

TimeframeStudies, this research(%)All Research%
pre-199074 (92.50)18.7374
1990's0 (0.00)18.2507
2000's1 (1.25)29.6817
2010's1 (1.25)24.3611
2020's4 (5.00)2.80

Authors

AuthorsStudies
Yasuda, H1
Hatano, T1
Honda, T1
Tsutsui, M1
Hattori, N1
Ando, M1
Komatsu, N1
Lizárraga, KJ1
Lang, AE1
Sardoeira, A1
Vila-Chã, N1
Corrá, M1
Sousa, AP1
Maetzler, W1
Maia, LF1
Li, W1
Yang, X1
Song, Q1
Cao, Z1
Shi, Y1
Deng, Y1
Zhang, L1
Raj, MA1
Gowthaman, NS1
John, SA1
SIGWALD, J2
ALLEVA, PM1
CHRISTIANSEN, J1
DALSGAARD-NIELSEN, T1
Tan, EK1
Cheah, SY1
Fook-Chong, S1
Yew, K1
Chandran, VR1
Lum, SY1
Yi, Z1
Namba, S2
Ishimitsu, H1
Nakasone, S1
Vaĭnshtok, AB1
Gonce, M1
Barbeau, A1
Bianchine, JR2
Shaw, GM1
Hanzal, F1
Omoto, T1
Kishikawa, H1
Johnson, RD1
Ruthven, CR1
Goodwin, BL1
Sandler, M1
Langan, RJ1
Cotzias, GC5
Martocci, RJ1
Mars, H4
Naess, K1
Burton, K1
Hunter, KR1
Stern, GM1
Laurence, DR1
Weiss, JL1
Ng, LK1
Chase, TN1
Mozzis, CE1
Prange, AJ2
Hall, CD2
Weiss, EA2
Johnston, GA1
Tran, N1
Carter, AB2
Tzavellas, O1
Hartmann-von Monakow, K1
Schmutzler, F1
Eichhorn, A1
Ericsson, AD1
McCann, DS1
Mazzoni, S1
Toffano, G1
Castellani, A1
Papavasiliou, PS3
Düby, SE1
Steck, AJ1
Fehling, C1
Bell, MA1
Yahr, MD4
Duvoisin, RC3
Côté, L1
Cohen, G2
Pfeiffer, RF1
Cassell, K1
Shaw, K1
Stern, G1
Lakke, JP1
Nienhuis, RJ1
Meyer, R1
Zwols, F1
Schut, T1
Kuzuya, F2
Wakita, T2
Kawahara, H2
Mawatari, S1
Izumi, K1
Kuroiwa, Y1
Tkachev, RA1
Markova, ED1
Gotovtseva, EV1
Barkhatova, VP1
Ivanova-Smolenskaia, IA1
Hsu, TH1
Preziosi, TJ1
Messiha, FS1
Klawans, HL3
Ringel, SP2
Wolf, SM1
Davis, RL1
Lawrence, WH1
Gehlen, W1
Fahn, S1
Mumenthaler, M1
Kaeser, HE1
Ferel, D1
Wurmser, P1
Diemath, HE1
Enge, S1
Lechner, H1
Lipman, IJ1
Ginos, J1
Steck, A1
Düby, S1
Morris, CE1
Van Woert, MH1
Barrera, ER1
Bennett, S1
Pfeiffer, R1
Ebadi, M1
Castaigne, P1
Rondot, P1
Ribadeau-Dumas, JL1
Shenker, DM1
Cote, LJ1
Abrams, WB2
Coutinho, CB1
Leon, AS2
Spiegel, HE2
Thomas, G1
Coté, LD1
Jameson, HD1
Golden, RL1
Mortati, FS1
Schroeter, GA1
Friedman, SA1
Kott, E1
Bornstein, B1
Eichhorn, F1
Cabot, EE1

Reviews

9 reviews available for pyridoxine and Parkinson Disease

ArticleYear
[The current treatment of Parkinson's disease].
    Revue medicale de Liege, 1976, Oct-10, Volume: 31, Issue:19

    Topics: Amantadine; Antidepressive Agents, Tricyclic; Dihydroxyphenylalanine; Drug Combinations; Histamine A

1976
Clinical pharmacokinetics of levodopa in parkinson's disease.
    Clinical pharmacokinetics, 1976, Volume: 1, Issue:5

    Topics: Carboxy-Lyases; Cardiovascular Diseases; Dopamine; Dose-Response Relationship, Drug; Dyskinesia, Dru

1976
Recent advances in the treatment of Parkinson's disease.
    The Journal of the American Osteopathic Association, 1975, Volume: 74, Issue:8

    Topics: Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Carbidopa; Depression, Chemical;

1975
[Antiparkinson agents. 50].
    Pharmazeutische Praxis, 1970, Volume: 12

    Topics: Atropine; Dihydroxyphenylalanine; Diphenhydramine; Histamine H1 Antagonists; Humans; Mephenesin; Mon

1970
Pyridoxine, DOPA, and Parkinsonism.
    Advances in biochemical psychopharmacology, 1972, Volume: 4

    Topics: Administration, Oral; Clinical Trials as Topic; Dihydroxyphenylalanine; Drug Antagonism; Drug Intera

1972
Comments on the adverse effect of concurrent pyridoxine administration on the efficacy of L-dopa in treating parkinsonism.
    The Nebraska medical journal, 1972, Volume: 57, Issue:9

    Topics: Dihydroxyphenylalanine; Drug Interactions; Humans; Models, Biological; Parkinson Disease; Pyridoxine

1972
[Clinical aspects and drug therapy of Parkinson's syndrome].
    Schweizerische medizinische Wochenschrift, 1966, Apr-16, Volume: 96, Issue:15

    Topics: Amphetamine; Diphenhydramine; Humans; Parasympatholytics; Parkinson Disease; Parkinson Disease, Post

1966
L-dopa therapy in Parkinson's disease.
    Virginia medical monthly, 1971, Volume: 98, Issue:5

    Topics: Delirium; Depression; Dihydroxyphenylalanine; Gastrointestinal Hemorrhage; Hallucinations; Humans; H

1971
Metabolic modification of Parkinson's disease and of chronic manganese poisoning.
    Annual review of medicine, 1971, Volume: 22

    Topics: Animals; Brain; Choline; Chronic Disease; Dihydroxyphenylalanine; Drug Synergism; Humans; Manganese

1971

Trials

4 trials available for pyridoxine and Parkinson Disease

ArticleYear
Functional COMT variant predicts response to high dose pyridoxine in Parkinson's disease.
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2005, Aug-05, Volume: 137B, Issue:1

    Topics: Activities of Daily Living; Aged; Antiparkinson Agents; Catechol O-Methyltransferase; Cross-Over Stu

2005
[Treatment of Parkinson's syndrome with L-dopa and L-carbidopa (author's transl)].
    MMW, Munchener medizinische Wochenschrift, 1976, May-14, Volume: 118, Issue:20

    Topics: Adult; Aged; Carbidopa; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Combination

1976
Levodopa in Parkinsonism: potentiation of central effects with a peripheral inhibitor.
    The New England journal of medicine, 1972, Jan-06, Volume: 286, Issue:1

    Topics: Administration, Oral; Adult; Biotransformation; Brain; Carbon Monoxide Poisoning; Cerebral Palsy; Ch

1972
Pyridoxine, DOPA, and Parkinsonism.
    Advances in biochemical psychopharmacology, 1972, Volume: 4

    Topics: Administration, Oral; Clinical Trials as Topic; Dihydroxyphenylalanine; Drug Antagonism; Drug Intera

1972

Other Studies

68 other studies available for pyridoxine and Parkinson Disease

ArticleYear
Vitamin B6 Deficiency Anemia Attributed to Levodopa/Carbidopa Intestinal Gel Therapy for Parkinson's Disease: A Diagnostic Pitfall for Myelodysplastic Syndrome with Ring Sideroblasts.
    Internal medicine (Tokyo, Japan), 2022, Dec-15, Volume: 61, Issue:24

    Topics: Aged; Anemia; Antiparkinson Agents; Carbidopa; Drug Combinations; Gels; Humans; Levodopa; Male; Myel

2022
Vitamins B6 and B12, levodopa, and their complex interactions in patients with Parkinson's disease.
    Brain : a journal of neurology, 2022, 09-14, Volume: 145, Issue:9

    Topics: Humans; Levodopa; Parkinson Disease; Pyridoxine; Vitamin B 6; Vitamins

2022
Reply: Vitamins B6 and B12, levodopa, and their complex interactions in patients with Parkinson's disease.
    Brain : a journal of neurology, 2022, 09-14, Volume: 145, Issue:9

    Topics: Humans; Levodopa; Parkinson Disease; Pyridoxine; Vitamin B 6; Vitamins

2022
Pyridoxine-resveratrol hybrids as novel inhibitors of MAO-B with antioxidant and neuroprotective activities for the treatment of Parkinson's disease.
    Bioorganic chemistry, 2020, Volume: 97

    Topics: Animals; Antioxidants; Humans; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase In

2020
Highly sensitive interference-free electrochemical determination of pyridoxine at graphene modified electrode: Importance in Parkinson and Asthma treatments.
    Journal of colloid and interface science, 2016, Jul-15, Volume: 474

    Topics: Asthma; Carbon; Electrochemical Techniques; Electrodes; Graphite; Oxides; Parkinson Disease; Particl

2016
[Indications for large doses of pyridoxine in neurology: Parkinson's disease, tremor of action (essential, lenticular and toxic tremor)].
    Medicina contemporanea (Lisbon, Portugal), 1957, Volume: 75, Issue:1

    Topics: Humans; Lens, Crystalline; Lenses; Neurology; Parkinson Disease; Pyridoxine; Tremor; Vitamin B 6

1957
[On the therapeutic effects of high doses of pyridoxine in extrapyramidal syndromes].
    Acta vitaminologica, 1960, Volume: 14

    Topics: Basal Ganglia Diseases; Parkinson Disease; Pyridoxine; Spasm; Syndrome; Vitamin B 6

1960
[Treatment of paralysis agitans with vitamin B6 (pyridoxine)].
    Ugeskrift for laeger, 1962, Dec-21, Volume: 124

    Topics: Humans; Parkinson Disease; Pyridoxine; Vitamin B 6

1962
[Treatment of paralysis agitans with pyridoxine].
    Ugeskrift for laeger, 1962, Nov-09, Volume: 124

    Topics: Parkinson Disease; Pyridoxine

1962
[Clinical significance of pyridoxine administration in L-dopa therapy of Parkinsonism (author's transl)].
    No to shinkei = Brain and nerve, 1980, Volume: 32, Issue:10

    Topics: Adult; Aged; Animals; Brain Chemistry; Carboxy-Lyases; Dopamine; Drug Therapy, Combination; Female;

1980
[Treatment of parkinsonism with large doses of vitamin B6].
    Sovetskaia meditsina, 1979, Issue:7

    Topics: Aged; Antiparkinson Agents; Female; Humans; Male; Middle Aged; Parkinson Disease; Pyridoxine

1979
[Effects of simultaneous administration of pyridoxine in the combined administration of L-dopa and peripheral decarboxylase inhibitors. Experimental and clinical studies].
    No to shinkei = Brain and nerve, 1976, Volume: 28, Issue:8

    Topics: Animals; Carbidopa; Carboxy-Lyases; Dogs; Drug Therapy, Combination; Female; Haplorhini; Humans; Lev

1976
In vivo assessment of decarboxylase inhibition or potentiation: urinary dopamine and L-dopa output after L-dopa administration.
    Journal of neural transmission, 1976, Volume: 38, Issue:3-4

    Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Carbidopa; Dopamine; Drug Intera

1976
Do's and don'ts for the patient on levodopa therapy.
    The American journal of nursing, 1976, Volume: 76, Issue:6

    Topics: Aromatic Amino Acid Decarboxylase Inhibitors; Diet; Dietary Proteins; Drug Antagonism; Ethanol; Huma

1976
Effect of chronic levodopa treatment on pyridoxine metabolism.
    Neurology, 1975, Volume: 25, Issue:3

    Topics: Aged; Erythrocytes; Humans; Levodopa; Middle Aged; Parkinson Disease; Plasma; Pyridoxal Phosphate; P

1975
[Pyridoxine (vitamin B 6) and parkinsonism].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1975, Nov-10, Volume: 95, Issue:31

    Topics: Adult; Aged; Humans; Middle Aged; Parkinson Disease; Pyridoxine

1975
The treatment of tremor.
    The Medical journal of Australia, 1987, Nov-16, Volume: 147, Issue:10

    Topics: Adrenergic beta-Antagonists; Alcoholic Beverages; Cerebellar Diseases; Humans; Isoniazid; Levodopa;

1987
Use of levodopa with other drugs.
    Lancet (London, England), 1970, Dec-19, Volume: 2, Issue:7686

    Topics: Adult; Aged; Antidepressive Agents; Antiemetics; Digoxin; Dihydroxyphenylalanine; Diuretics; Drug An

1970
L-dopa. II.
    British medical journal, 1970, Nov-28, Volume: 4, Issue:5734

    Topics: Anorexia Nervosa; Cardiac Complexes, Premature; Dihydroxyphenylalanine; Drug Synergism; Humans; Hypo

1970
Long-lasting dyskinesia induced by levodopa.
    Lancet (London, England), 1971, May-15, Volume: 1, Issue:7707

    Topics: Adult; Dihydroxyphenylalanine; Female; Humans; Injections; Injections, Intramuscular; Movement Disor

1971
Inefficacy of tryptophan-pyridoxine in essential tremor.
    Lancet (London, England), 1971, Jul-17, Volume: 2, Issue:7716

    Topics: Basal Ganglia; Dihydroxyphenylalanine; Drug Synergism; Female; Humans; Male; Parkinson Disease; Pyri

1971
L-dopa and vitamin B 6 .
    Lancet (London, England), 1971, Jul-24, Volume: 2, Issue:7717

    Topics: Chemical Phenomena; Chemistry; Dihydroxyphenylalanine; Humans; Parkinson Disease; Pyridoxine

1971
Levodopa.
    Lancet (London, England), 1971, Sep-04, Volume: 2, Issue:7723

    Topics: Dihydroxyphenylalanine; Humans; Parkinson Disease; Phenylacetates; Pyridoxine; Time Factors

1971
L-Dopa and pyridoxine.
    Lancet (London, England), 1972, Jul-01, Volume: 2, Issue:7766

    Topics: Decarboxylation; Dihydroxyphenylalanine; Dopamine; Humans; Oxidation-Reduction; Parkinson Disease; P

1972
Letter: Pyridoxine contraindicated in parkinsonism.
    Lancet (London, England), 1973, Oct-20, Volume: 2, Issue:7834

    Topics: Dihydroxyphenylalanine; Drug Antagonism; Humans; Metoclopramide; Nausea; Parkinson Disease; Pyridoxi

1973
Letter: Pyridoxine in parkinsonism.
    Lancet (London, England), 1973, Nov-03, Volume: 302, Issue:7836

    Topics: Dihydroxyphenylalanine; Drug Antagonism; Drug Interactions; Humans; Metoclopramide; Movement Disorde

1973
[The effect of vitamin B 12 in combination with 4-chlortestosterone acetate on Parkinson's syndrome and hyperkinesia].
    Arzneimittel-Forschung, 1967, Volume: 17, Issue:7

    Topics: Adult; Aged; Blood Pressure; Body Weight; Drug Tolerance; Female; Folic Acid; Humans; Hyperkinesis;

1967
[Specific therapy of extrapyramidal-motor syndromes].
    Bibliotheca psychiatrica et neurologica, 1969, Volume: 139

    Topics: Analgesics; Athetosis; Chorea; Datura stramonium; Dihydroxyphenylalanine; Dystonia Musculorum Deform

1969
[The essentially tremulous forms of Parkinson's syndrome. Prognostic importance of a mixed tremor (combined intention tremor and resting tremor)].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1968, May-26, Volume: 44, Issue:25

    Topics: Humans; Motor Activity; Parkinson Disease; Pyridoxine; Tremor

1968
Dihydroxyphenylacetic acid in the treatment of Parkinsonism.
    Advances in neurology, 1974, Volume: 5

    Topics: Antiparkinson Agents; Catechol O-Methyltransferase Inhibitors; Drug Therapy, Combination; Enzyme Inh

1974
[Effect of brain cortex phospholipids on some enzymatic reactions of cerebral amino acid decarboxylation and possible therapeutic implications (author's transl)].
    Rivista di patologia nervosa e mentale, 1974, Volume: 95, Issue:5

    Topics: Amino Acids; Animals; Brain; Cerebral Cortex; Decarboxylation; Humans; Mice; Parkinson Disease; Phos

1974
A computerised tracking technique for the assessment of Parkinsonian motor disabilities.
    Brain : a journal of neurology, 1973, Volume: 96, Issue:4

    Topics: Adult; Aged; Diagnosis, Computer-Assisted; Dihydroxyphenylalanine; Disability Evaluation; Evaluation

1973
[L-DOPA with the decarboxylase inhibitor Ro 4-4602 in the treatment of Parkinson's disease].
    Nederlands tijdschrift voor geneeskunde, 1972, Nov-25, Volume: 116, Issue:48

    Topics: Aromatic Amino Acid Decarboxylase Inhibitors; Dihydroxyphenylalanine; Humans; Parkinson Disease; Pyr

1972
[Symposium: metabolism in neurological disorders. 1. Parkinsonism. 1-(2). Dopamin metabolism in urine and brain of patients with parkinsonism, with special reference to vitamin B 6 and L-DOPA-treatment].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1972, Volume: 61, Issue:9

    Topics: Animals; Brain; Dihydroxyphenylalanine; Dopamine; Humans; Male; Parkinson Disease; Pyridoxine; Rats

1972
[L-dopa treatment and vitamin B 6 --clinical and chemical studies].
    Rinsho shinkeigaku = Clinical neurology, 1972, Volume: 12, Issue:2

    Topics: Aged; Dihydroxyphenylalanine; Female; Humans; Male; Middle Aged; Parkinson Disease; Pyridoxine

1972
Levodopa and related drugs.
    The Medical letter on drugs and therapeutics, 1973, Mar-02, Volume: 15, Issue:5

    Topics: Amantadine; Apomorphine; Dihydroxyphenylalanine; Humans; Hydrazines; Hypotension; Mental Disorders;

1973
[Principles of the pathogenetic therapy of congenital extrapyramidal diseases].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1973, Volume: 73, Issue:4

    Topics: Adolescent; Adult; Atropine; Basal Ganglia Diseases; Chelating Agents; Chronic Disease; Dihydroxyphe

1973
Effect of pyridoxine on levodopa metabolism in normal and parkinsonian subjects.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1973, Volume: 143, Issue:2

    Topics: Aged; Dihydroxyphenylalanine; Humans; Middle Aged; Parkinson Disease; Pharmaceutic Aids; Pyridoxine;

1973
L-Dopa, B 6 , and alpha-methyldopa hydrazine.
    Confinia neurologica, 1973, Volume: 35, Issue:3

    Topics: Adult; Aged; Aromatic Amino Acid Decarboxylase Inhibitors; Brain; Carbidopa; Dihydroxyphenylalanine;

1973
Permanent dementia in idiopathic Parkinsonism treated with levodopa.
    Archives of neurology, 1973, Volume: 29, Issue:4

    Topics: Aged; Amantadine; Brain; Dihydroxyphenylalanine; Electroencephalography; Humans; Male; Parkinson Dis

1973
Levodopa and dopamine in cerebrospinal fluid.
    Neurology, 1973, Volume: 23, Issue:7

    Topics: Aged; Aromatic Amino Acid Decarboxylase Inhibitors; Benztropine; Carbidopa; Dihydroxyphenylalanine;

1973
[Administration of L-dopa in Parkinson's syndrome and vitamin B6 metabolism].
    Nihon rinsho. Japanese journal of clinical medicine, 1973, Volume: 31, Issue:5

    Topics: Aged; Dihydroxyphenylalanine; Female; Humans; Male; Middle Aged; Parkinson Disease; Pyridoxine

1973
Letter: Pyridoxine and Parkinsonism.
    British medical journal, 1973, Oct-27, Volume: 4, Issue:5886

    Topics: Dihydroxyphenylalanine; Humans; Nausea; Parkinson Disease; Pyridoxine

1973
Metabolic interactions of pyridoxine, levodopa, and carbidopa in Parkinson's disease.
    Transactions of the American Neurological Association, 1973, Volume: 98

    Topics: Brain; Carbidopa; Dihydroxyphenylalanine; Dopa Decarboxylase; Dopamine; Homovanillic Acid; Humans; H

1973
Levodopa, carbidopa, and pyridoxine in Parkinson disease. Metabolic interactions.
    Archives of neurology, 1974, Volume: 30, Issue:6

    Topics: Carbidopa; Dihydroxyphenylalanine; Dopa Decarboxylase; Dopamine; Drug Interactions; Drug Synergism;

1974
[Differential treatment of Parkinson's disease, with special reference to the possibility of iatrogenic disorders (author's transl)].
    Archiv fur Psychiatrie und Nervenkrankheiten, 1974, Apr-09, Volume: 218, Issue:4

    Topics: Amantadine; Anesthetics; Anti-Bacterial Agents; Antidepressive Agents; Antihypertensive Agents; Anti

1974
"On-off" phenomenon with levodopa therapy in Parkinsonism. Clinical and pharmacologic correlations and the effect of intramuscular pyridoxine.
    Neurology, 1974, Volume: 24, Issue:5

    Topics: Adult; Carbidopa; Dihydroxyphenylalanine; Drug Synergism; Evaluation Studies as Topic; Female; Homov

1974
[Treatment of Parkinson's syndrome with L-dopa].
    Schweizerische medizinische Wochenschrift, 1970, May-09, Volume: 100, Issue:19

    Topics: Aged; Anti-Bacterial Agents; Anti-Infective Agents, Urinary; Antihypertensive Agents; Barbiturates;

1970
EEG depth leads during stereotaxic brain surgery. A report on 117 cases (5 target points, effects of 13 different drugs).
    Confinia neurologica, 1970, Volume: 32, Issue:2

    Topics: Amides; Amygdala; Antimetabolites; Asparagine; Benzoates; Brain; Brain Diseases; Cerebrovascular Cir

1970
Rapid deterioration in patients with parkinsonism following tryptophan-pyridoxine administration.
    Neurology, 1972, Volume: 22, Issue:3

    Topics: Adult; Brain; Drug Synergism; Humans; Male; Middle Aged; Parkinson Disease; Pyridoxine; Reaction Tim

1972
Low pyridoxine diet in parkinsonism.
    JAMA, 1972, Feb-28, Volume: 219, Issue:9

    Topics: Diet Therapy; Dihydroxyphenylalanine; Humans; Parkinson Disease; Pyridoxine; Vitamin B 6 Deficiency

1972
Levadopa and pyridoxine.
    JAMA, 1972, Mar-27, Volume: 219, Issue:13

    Topics: Animals; Brain; Carboxy-Lyases; Decarboxylation; Dihydroxyphenylalanine; Drug Interactions; Humans;

1972
Pyridoxine and levodopa in the treatment of Parkinsonism.
    JAMA, 1972, May-08, Volume: 220, Issue:6

    Topics: Dihydroxyphenylalanine; Humans; Parkinson Disease; Pyridoxine

1972
On the mechanism of the nullification of CNS effects of L-DOPA by pyridoxine in Parkinsonian patients.
    Journal of neurochemistry, 1972, Volume: 19, Issue:9

    Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Basal Ganglia; Benzyl Compounds; Dihydroxyphe

1972
[Medical treatment of Parkinson's disease].
    Annales de medecine interne, 1972, Volume: 123, Issue:4

    Topics: Amantadine; Carboxy-Lyases; Dihydroxyphenylalanine; Humans; Parasympatholytics; Parkinson Disease; P

1972
Effect of vitamin B 6 on levodopa-induced changes in spinal fluid homovanillic acid.
    Journal of the neurological sciences, 1971, Volume: 14, Issue:4

    Topics: Dihydroxyphenylalanine; Dopamine; Female; Humans; Middle Aged; Parkinson Disease; Phenylacetates; Py

1971
Failure of vitamin B6 to reverse the L-dopa effect in patients on a dopa decarboxylase inhibitor.
    Journal of neurology, neurosurgery, and psychiatry, 1971, Volume: 34, Issue:6

    Topics: Adult; Aged; Aromatic Amino Acid Decarboxylase Inhibitors; Dihydroxyphenylalanine; Dopa Decarboxylas

1971
The metabolism of orally administered L-dopa in Parkinson patients.
    Transactions of the American Neurological Association, 1971, Volume: 96

    Topics: Dihydroxyphenylalanine; Dopamine; Epinephrine; Humans; Norepinephrine; Parkinson Disease; Phenylacet

1971
Absorption and metabolism of levodopa.
    JAMA, 1971, Dec-27, Volume: 218, Issue:13

    Topics: Animals; Decarboxylation; Dihydroxyphenylalanine; Dogs; Dopamine; Humans; Intestinal Absorption; Liv

1971
Pyridoxine antagonism of levodopa in parkinsonism.
    JAMA, 1971, Dec-27, Volume: 218, Issue:13

    Topics: Aged; Chromatography, Thin Layer; Decarboxylation; Dihydroxyphenylalanine; Dopamine; Female; Humans;

1971
Pyridoxine reversal of L-dopa effects in Parkinsonism.
    Transactions of the American Neurological Association, 1969, Volume: 94

    Topics: Chorea; Dihydroxyphenylalanine; Humans; Parkinson Disease; Pyridoxine

1969
Metabolic modification of some neurologic disorders.
    JAMA, 1969, Nov-17, Volume: 210, Issue:7

    Topics: Dihydroxyphenylalanine; Dopamine; Humans; Male; Manganese; Manganese Poisoning; Parkinson Disease; P

1969
Pyridoxine for levodopa-induced dystonia.
    JAMA, 1970, Mar-09, Volume: 211, Issue:10

    Topics: Dihydroxyphenylalanine; Humans; Male; Middle Aged; Muscular Diseases; Parkinson Disease; Pyridoxine;

1970
Levodopa, pyridoxine, and the burning feet syndrome.
    JAMA, 1970, Jul-27, Volume: 213, Issue:4

    Topics: Aged; Dihydroxyphenylalanine; Drug Antagonism; Foot Diseases; Humans; Male; Parkinson Disease; Pyrid

1970
Levodopa and pyridoxine-deficient states.
    JAMA, 1970, Nov-23, Volume: 214, Issue:8

    Topics: Dihydroxyphenylalanine; Humans; Parkinson Disease; Pyridoxine; Vitamin B 6 Deficiency

1970
Excretion of dopa metabolites.
    The New England journal of medicine, 1971, Feb-18, Volume: 284, Issue:7

    Topics: Dihydroxyphenylalanine; Dopamine; Humans; Parkinson Disease; Phenylacetates; Pyridoxine

1971
[Vitamin tablets and patients with parkinsonism].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1971, Jun-10, Volume: 91, Issue:16

    Topics: Dihydroxyphenylalanine; Humans; Parkinson Disease; Pyridoxine; Vitamins

1971
Physician's advice needed in diets for Parkinsonism.
    Modern hospital, 1971, Volume: 116, Issue:5

    Topics: Diet; Dihydroxyphenylalanine; Food Service, Hospital; Humans; Parkinson Disease; Pyridoxine

1971