Page last updated: 2024-10-20

pyridoxine and Neuroblastoma

pyridoxine has been researched along with Neuroblastoma in 7 studies

4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).

Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

Research Excerpts

ExcerptRelevanceReference
" Isoniazid and its metabolites including acetylisoniazid, acetylhydrazine, diacetylhydrazine, isonicotinic acid and hydrazine were examined for their potential neurotoxic effects in cultured mouse dorsal root ganglion (DRG) neurons and mouse neuroblastoma x DRG neuron hybrid cell line N18D3."3.70Neurotoxicity of isoniazid and its metabolites in cultures of mouse dorsal root ganglion neurons and hybrid neuronal cell line. ( Kim, SU; Sanfeliu, C; Wright, JM, 1999)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19905 (71.43)18.7374
1990's2 (28.57)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sanfeliu, C1
Wright, JM1
Kim, SU1
Plöchl, E2
Eastman, CL1
Guilarte, TR1
Kiley, VA1
Lazerson, J1
Shaw, KN1
Lieberman, E1
Koch, R1
Donnell, GN1
Mönch, E1
Stefan, H1
Käser, H1

Reviews

1 review available for pyridoxine and Neuroblastoma

ArticleYear
Cytotoxicity of 3-hydroxykynurenine: implications for CNS damage in neonatal vitamin B-6 deficiency.
    Advances in experimental medicine and biology, 1991, Volume: 294

    Topics: Animals; Animals, Newborn; Antioxidants; Brain; Brain Chemistry; Cell Death; Hybrid Cells; Hydrolase

1991

Other Studies

6 other studies available for pyridoxine and Neuroblastoma

ArticleYear
Neurotoxicity of isoniazid and its metabolites in cultures of mouse dorsal root ganglion neurons and hybrid neuronal cell line.
    Neurotoxicology, 1999, Volume: 20, Issue:6

    Topics: Animals; Antitubercular Agents; Catalase; Cell Survival; Cells, Cultured; Dose-Response Relationship

1999
[Genetic and biochemical studies on familial neuroblastoma].
    Fortschritte der Medizin, 1979, Sep-13, Volume: 97, Issue:34

    Topics: Adrenal Gland Neoplasms; Coenzymes; Cystathionine; Cystathionine gamma-Lyase; Humans; Infant, Newbor

1979
[Biochemical studies on familial neuroblastoma].
    Padiatrie und Padologie, 1978, Volume: 13, Issue:2

    Topics: Adult; Child; Cystathionine; Female; Humans; Male; Mutation; Neuroblastoma; Oxalates; Pedigree; Pyri

1978
Agenesis of the corpus callosum and neural crest tumors.
    Pediatric hematology and oncology, 1986, Volume: 3, Issue:2

    Topics: Abdominal Neoplasms; Abnormalities, Drug-Induced; Agenesis of Corpus Callosum; Child; Child, Prescho

1986
Cystathioninuria.
    American journal of diseases of children (1960), 1967, Volume: 113, Issue:1

    Topics: Adult; Amino Acid Metabolism, Inborn Errors; Amino Acids; Carcinoma, Hepatocellular; Child, Preschoo

1967
[Pepper type neuroblastoma with homocystinuria. Diagnosis, biochemistry and therapy].
    Helvetica paediatrica acta, 1970, Volume: 25, Issue:5

    Topics: Amino Acids; Catecholamines; Child, Preschool; Cyclophosphamide; Dopamine; Homocystinuria; Humans; L

1970