pyridoxine has been researched along with Nausea in 103 studies
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report information about an unpublished 1970s study ("8-way" Bendectin Study) that aimed to evaluate the relative therapeutic efficacy of doxylamine, pyridoxine, and dicyclomine in the management of nausea and vomiting during pregnancy." | 9.24 | 8-Way Randomized Controlled Trial of Doxylamine, Pyridoxine and Dicyclomine for Nausea and Vomiting during Pregnancy: Restoration of Unpublished Information. ( Persaud, N; Zhang, R, 2017) |
| "Doxylamine succinate-pyridoxine hydrochloride delayed release combination is safe and well tolerated by pregnant women when used in the recommended dose of up to 4 tablets daily in treating nausea and vomiting of pregnancy." | 9.20 | Maternal safety of the delayed-release doxylamine and pyridoxine combination for nausea and vomiting of pregnancy; a randomized placebo controlled trial. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Matok, I; Mattison, DR; Miodovnik, M; Umans, JG, 2015) |
| "To evaluate whether ondansetron or the combination of doxylamine and pyridoxine was superior for the treatment of nausea and vomiting of pregnancy." | 9.19 | Ondansetron compared with doxylamine and pyridoxine for treatment of nausea in pregnancy: a randomized controlled trial. ( Capp, SM; Carstairs, SD; Oliveira, LG; Riffenburgh, RH; You, WB, 2014) |
| " The authors' objective is to identify the determinants of adherence to delayed-release doxylamine-pyridoxine (Diclectin) in patients with nausea and vomiting of pregnancy (NVP)." | 9.16 | Determinants of adherence to delayed-release doxylamine and pyridoxine in patients with nausea and vomiting of pregnancy. ( Caritis, S; Chiossi, G; Clark, S; Costantine, MM; Hankins, GD; Koren, G; Matok, I; Miodovnik, M; Umans, JG, 2012) |
| "To evaluate the effectiveness of Diclectin (doxylamine succinate 10 mg-pyridoxine hydrochloride 10 mg, delayed-release preparation) as compared with placebo for nausea and vomiting of pregnancy." | 9.14 | Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Mattison, DR; Miodovnik, M; Umans, JG, 2010) |
| "There was a significant decrease in the mean of posttherapy minus baseline nausea scores in the pyridoxine compared with that in the placebo group (t test, p = 0." | 9.08 | Pyridoxine for nausea and vomiting of pregnancy: a randomized, double-blind, placebo-controlled trial. ( Ruangsri, R; Vutyavanich, T; Wongtra-ngan, S, 1995) |
| "Diclectin (pyridoxine 10 mg and doxylamine 10 mg) has traditionally been used to treat nausea and vomiting of pregnancy (NVP); however, this drug is unavailable in many countries." | 7.79 | Evaluation of the efficacy and safety of bi-daily combination therapy with pyridoxine and doxylamine for nausea and vomiting of pregnancy. ( Ashkenazi-Hoffnung, L; Klinger, G; Merlob, P; Stahl, B, 2013) |
| "A delayed-release combination of doxylamine-pyridoxine (D-P) (Diclectin) is the only approved antiemetic medication for use in pregnancy in Canada." | 7.71 | The safety of higher than standard dose of doxylamine-pyridoxine (Diclectin) for nausea and vomiting of pregnancy. ( Atanackovic, G; Koren, G; Moretti, ME; Navioz, Y, 2001) |
| "An effective and safe treatment for nausea and vomiting of pregnancy (NVP) is lacking." | 7.30 | Acupuncture and Doxylamine-Pyridoxine for Nausea and Vomiting in Pregnancy : A Randomized, Controlled, 2 ( An, CM; Cao, YJ; Chen, XY; Cong, J; Cui, YM; Feng, YH; Gao, JS; Hu, YH; Li, J; Li, L; Liu, JP; Liu, L; Liu, YX; Liu, ZL; Liu, ZS; Lu, ZL; Ma, HL; Mol, BWJ; Ng, EHY; Painter, RC; Qi, X; Qin, HC; Wang, CC; Wang, Y; Wang, YX; Wu, Q; Wu, XK; Yan, Y; Yang, XM; Yu, L; Zhang, B; Zhou, LL, 2023) |
| "We report information about an unpublished 1970s study ("8-way" Bendectin Study) that aimed to evaluate the relative therapeutic efficacy of doxylamine, pyridoxine, and dicyclomine in the management of nausea and vomiting during pregnancy." | 5.24 | 8-Way Randomized Controlled Trial of Doxylamine, Pyridoxine and Dicyclomine for Nausea and Vomiting during Pregnancy: Restoration of Unpublished Information. ( Persaud, N; Zhang, R, 2017) |
| "Doxylamine succinate-pyridoxine hydrochloride delayed release combination is safe and well tolerated by pregnant women when used in the recommended dose of up to 4 tablets daily in treating nausea and vomiting of pregnancy." | 5.20 | Maternal safety of the delayed-release doxylamine and pyridoxine combination for nausea and vomiting of pregnancy; a randomized placebo controlled trial. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Matok, I; Mattison, DR; Miodovnik, M; Umans, JG, 2015) |
| "To evaluate whether ondansetron or the combination of doxylamine and pyridoxine was superior for the treatment of nausea and vomiting of pregnancy." | 5.19 | Ondansetron compared with doxylamine and pyridoxine for treatment of nausea in pregnancy: a randomized controlled trial. ( Capp, SM; Carstairs, SD; Oliveira, LG; Riffenburgh, RH; You, WB, 2014) |
| " The authors' objective is to identify the determinants of adherence to delayed-release doxylamine-pyridoxine (Diclectin) in patients with nausea and vomiting of pregnancy (NVP)." | 5.16 | Determinants of adherence to delayed-release doxylamine and pyridoxine in patients with nausea and vomiting of pregnancy. ( Caritis, S; Chiossi, G; Clark, S; Costantine, MM; Hankins, GD; Koren, G; Matok, I; Miodovnik, M; Umans, JG, 2012) |
| "To evaluate the effectiveness of Diclectin (doxylamine succinate 10 mg-pyridoxine hydrochloride 10 mg, delayed-release preparation) as compared with placebo for nausea and vomiting of pregnancy." | 5.14 | Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Mattison, DR; Miodovnik, M; Umans, JG, 2010) |
| " We used as a motivating example the possible teratogenic risks of antiemetic agents in pregnancy since a large observational study recently showed that first-trimester exposure to doxylamine-pyridoxine was associated with significantly increased risk of congenital malformations as a whole, as well as central nervous system defects, and previous observational studies did not show such associations." | 5.12 | Misleading meta-analyses of observational studies may generate unjustified alarms: The case of medications for nausea and vomiting in pregnancy. ( Biffi, A; Cetin, I; Corrao, G; Filippelli, A; Locatelli, A; Rea, F, 2021) |
| "Combination therapy with pyridoxine and metoclopramide appears to be superior to either monotherapy in the treatment of nausea and vomiting in pregnancy." | 5.10 | Comparison of three outpatient regimens in the management of nausea and vomiting in pregnancy. ( Bsat, FA; Hoffman, DE; Seubert, DE, 2003) |
| "There was a significant decrease in the mean of posttherapy minus baseline nausea scores in the pyridoxine compared with that in the placebo group (t test, p = 0." | 5.08 | Pyridoxine for nausea and vomiting of pregnancy: a randomized, double-blind, placebo-controlled trial. ( Ruangsri, R; Vutyavanich, T; Wongtra-ngan, S, 1995) |
| " A randomized, triple-blinded controlled trial of 124 women was done to evaluate the effect of taking 150 mg of vitamin B6 daily for 30 days on the severity of nausea, headache, vomiting, dizziness, depression, and irritability associated with the initiation of low-dose (30 micrograms norgestrel and 30 micrograms ethinyl estradiol) OG use." | 5.08 | Effect of vitamin B6 on the side effects of a low-dose combined oral contraceptive. ( Grubb, GS; Juárez-Perez, MA; Ponce de León, R; Villegas-Salas, E, 1997) |
| "Fifty-nine women completed a randomized, double-blind placebo-controlled study of pyridoxine hydrochloride (vitamin B6) for the treatment of nausea and vomiting of pregnancy." | 5.07 | Vitamin B6 is effective therapy for nausea and vomiting of pregnancy: a randomized, double-blind placebo-controlled study. ( Niebyl, J; Rose, N; Rouse, D; Sahakian, V; Sipes, S, 1991) |
| "A double-blind comparison was undertaken between Debendox with 10mg of extra pyridoxine and placebo with 10mg of pyridoxine, in 56 women suffering from nausea and/or vomiting during the first 10 weeks of pregnancy." | 5.04 | Treatment of pregnancy sickness. ( Wheatley, D, 1977) |
| "For mild symptoms of nausea and emesis of pregnancy, ginger, pyridoxine, antihistamines, and metoclopramide were associated with greater benefit than placebo." | 4.93 | Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review. ( Beyer, F; Bradley, J; Bryant, A; McParlin, C; Moloney, E; Muirhead, CR; Nelson-Piercy, C; Newbury-Birch, D; Norman, J; O'Donnell, A; Robson, SC; Shaw, C; Simpson, E; Swallow, B; Vale, L; Yates, L, 2016) |
| "Ten randomized trials studying the effects of acupressure, ginger, and pyridoxine on nausea and vomiting of pregnancy were reviewed." | 4.80 | Alternative therapies for nausea and vomiting of pregnancy. ( Aikins Murphy, P, 1998) |
| "Using the Quebec Pregnancy Cohort (1998-2015), first-trimester doxylamine-pyridoxine, metoclopramide, and ondansetron exposures were assessed for their association with MCM." | 3.91 | New evidence for concern over the risk of birth defects from medications for nausea and vomitting of pregnancy. ( Bérard, A; Bernatsky, S; Gorgui, J; Sheehy, O; Soares de Moura, C; Zhao, JP, 2019) |
| "Diclectin (pyridoxine 10 mg and doxylamine 10 mg) has traditionally been used to treat nausea and vomiting of pregnancy (NVP); however, this drug is unavailable in many countries." | 3.79 | Evaluation of the efficacy and safety of bi-daily combination therapy with pyridoxine and doxylamine for nausea and vomiting of pregnancy. ( Ashkenazi-Hoffnung, L; Klinger, G; Merlob, P; Stahl, B, 2013) |
| "Diclectin, composed of 10 mg doxylamine succinate (DOX) and 10 mg pyridoxine hydrochloride, is the drug combination of choice for the management of nausea and vomiting during pregnancy in Canada." | 3.77 | Systemic bioavailability and pharmacokinetics of the doxylamine-pyridoxine delayed-release combination (Diclectin). ( Garcia-Bournissen, F; Gill, SK; Koren, G, 2011) |
| "Women who called the Motherisk NVP helpline, and were taking only Diclectin (vitamin B6 10 mg and doxylamine 10 mg), were enrolled in the study and assessed for the severity of nausea and vomiting of pregnancy (NVP) with the Motherisk-PUQE (pregnancy-unique quantification of emesis and nausea) scoring system." | 3.72 | Diclectin therapy for nausea and vomiting of pregnancy: effects of optimal dosing. ( Boskovic, R; Einarson, A; Koren, G; Maltepe, C; Wolpin, J, 2003) |
| "A delayed-release combination of doxylamine-pyridoxine (D-P) (Diclectin) is the only approved antiemetic medication for use in pregnancy in Canada." | 3.71 | The safety of higher than standard dose of doxylamine-pyridoxine (Diclectin) for nausea and vomiting of pregnancy. ( Atanackovic, G; Koren, G; Moretti, ME; Navioz, Y, 2001) |
| "Several controlled trials show the efficacy of prednisone for nausea and vomiting of pregnancy (NVP), but your case is fascinating in proving the point by challenge-rechallenge." | 3.70 | Managing women with nausea and vomiting of pregnancy. Canadian consensus. ( , 2000) |
| " Although no definitive causative factor has been identified in previously reported cases, the affection in our case is possibly related to Debendox (Bendectin) and nitrofurantoin taken in early pregnancy for nausea and renal tract infection, respectively." | 3.69 | Congenital symmetrical weakness of the upper limbs resembling brachial plexus palsy: a possible sequel of drug toxicity in first trimester of pregnancy? ( Dubowitz, V; Muntoni, F; Philpot, J; Skellett, S, 1995) |
| "The author summarizes the theoretical aspects of vomiting and alleviation of the same by surveying the respective scientific communications with special regard to thiethylperazine." | 3.68 | Torecan, a review of references and clinical control examinations. ( Rádi, A, 1990) |
| "The antinausea drug combination, doxylamine/dicyclomine/pyridoxine (Debendox or Bendectin [US] ), has been withdrawn from the market because of litigation based upon charges that it causes congenital limb defects." | 3.67 | The innocent bystander. Doxylamine/dicyclomine/pyridoxine and congenital limb defects. ( Elliott, J; Forrest, J; Kricker, A; McCredie, J, 1984) |
| "An effective and safe treatment for nausea and vomiting of pregnancy (NVP) is lacking." | 3.30 | Acupuncture and Doxylamine-Pyridoxine for Nausea and Vomiting in Pregnancy : A Randomized, Controlled, 2 ( An, CM; Cao, YJ; Chen, XY; Cong, J; Cui, YM; Feng, YH; Gao, JS; Hu, YH; Li, J; Li, L; Liu, JP; Liu, L; Liu, YX; Liu, ZL; Liu, ZS; Lu, ZL; Ma, HL; Mol, BWJ; Ng, EHY; Painter, RC; Qi, X; Qin, HC; Wang, CC; Wang, Y; Wang, YX; Wu, Q; Wu, XK; Yan, Y; Yang, XM; Yu, L; Zhang, B; Zhou, LL, 2023) |
| "Ninety-eight patients with metastatic breast cancer, heavily pretreated with other agents, were entered in a phase II trial of hexamethylmelamine (HEX)." | 2.65 | Phase II evaluation of hexamethylmelamine in advanced breast cancer: a Southwest Oncology Group study. ( Balcerzak, S; Fabian, CJ; Haut, A; Rasmussen, S; Smith, F; Stephens, R; Tranum, B, 1979) |
| "Nausea and vomiting are common in early pregnancy." | 2.50 | The pharmacologic management of nausea and vomiting of pregnancy. ( Briggs, GG; Niebyl, JR, 2014) |
| "Nausea and vomiting affects a large proportion of women in early pregnancy, yet because it is a physiological symptom it is often dismissed by health professionals, leaving women to find their own coping mechanisms." | 2.41 | Nausea and vomiting in pregnancy: safety and efficacy of self-administered complementary therapies. ( Tiran, D, 2002) |
| " Pyridoxine is considered safe for use during pregnancy, but its efficacy in treating nausea and vomiting has not been determined." | 2.37 | Safety and efficacy of antiemetics used to treat nausea and vomiting in pregnancy. ( Leathem, AM, 1986) |
| " There are different pharmaceutical dosage forms in the European market." | 1.72 | Comparative dissolution profiles of two anti-emetic delayed release dosage forms of doxylamine and pyridoxine: Xonvea® tablets vs. Cariban® capsules. ( Alcocer, C; Gergic, E; Hoarau, D; Iraola, M; Perez de la Cruz, MA; Regidor, PA; Rom, E, 2022) |
| " Thus, in France, as in other countries, vitamin B6 could be integrated into the therapeutic arsenal of mild to moderate nausea and vomiting during pregnancy according to the following dosage schedule: oral intake of 10mg four times a day of a compounded preparation of vitamin B6, alone or in combination with doxylamine." | 1.56 | [Interest of vitamin b6 for treatment of nausea and/or vomiting during pregnancy]. ( Pecriaux, C, 2020) |
| "Case infants (n = 998) had nonsyndromic congenital heart defects and control infants (n = 3,029) had no congenital defects." | 1.30 | Nausea during pregnancy and congenital heart defects: a population-based case-control study. ( Boneva, RS; Botto, L; Erickson, JD; Moore, CA; Wong, LY, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 50 (48.54) | 18.7374 |
| 1990's | 12 (11.65) | 18.2507 |
| 2000's | 17 (16.50) | 29.6817 |
| 2010's | 17 (16.50) | 24.3611 |
| 2020's | 7 (6.80) | 2.80 |
| Authors | Studies |
|---|---|
| Alcocer, C | 1 |
| Iraola, M | 1 |
| Rom, E | 1 |
| Hoarau, D | 1 |
| Gergic, E | 1 |
| Perez de la Cruz, MA | 1 |
| Regidor, PA | 1 |
| Schrager, NL | 1 |
| Parker, SE | 1 |
| Werler, MM | 1 |
| Jayawardena, R | 1 |
| Majeed, S | 1 |
| Sooriyaarachchi, P | 1 |
| Abeywarne, U | 1 |
| Ranaweera, P | 1 |
| Saz-Leal, P | 1 |
| Zamorano-Domínguez, L | 1 |
| Frías, J | 1 |
| Guerra, P | 1 |
| Saura-Valls, M | 1 |
| Roca-Juanes, R | 1 |
| Nebot-Troyano, J | 1 |
| García-Aguilar, E | 1 |
| Vilchez, T | 1 |
| Urso, K | 1 |
| Wu, XK | 1 |
| Gao, JS | 1 |
| Ma, HL | 1 |
| Wang, Y | 1 |
| Zhang, B | 1 |
| Liu, ZL | 1 |
| Li, J | 1 |
| Cong, J | 1 |
| Qin, HC | 1 |
| Yang, XM | 1 |
| Wu, Q | 1 |
| Chen, XY | 1 |
| Lu, ZL | 1 |
| Feng, YH | 1 |
| Qi, X | 1 |
| Wang, YX | 1 |
| Yu, L | 1 |
| Cui, YM | 1 |
| An, CM | 1 |
| Zhou, LL | 1 |
| Hu, YH | 1 |
| Li, L | 1 |
| Cao, YJ | 1 |
| Yan, Y | 1 |
| Liu, L | 1 |
| Liu, YX | 1 |
| Liu, ZS | 1 |
| Painter, RC | 2 |
| Ng, EHY | 1 |
| Liu, JP | 1 |
| Mol, BWJ | 1 |
| Wang, CC | 1 |
| Fejzo, MS | 1 |
| Trovik, J | 1 |
| Grooten, IJ | 1 |
| Sridharan, K | 1 |
| Roseboom, TJ | 1 |
| Vikanes, Å | 1 |
| Mullin, PM | 1 |
| Pecriaux, C | 1 |
| Biffi, A | 1 |
| Rea, F | 1 |
| Locatelli, A | 1 |
| Cetin, I | 1 |
| Filippelli, A | 1 |
| Corrao, G | 1 |
| Abbas, AM | 1 |
| Bérard, A | 1 |
| Sheehy, O | 1 |
| Gorgui, J | 1 |
| Zhao, JP | 1 |
| Soares de Moura, C | 1 |
| Bernatsky, S | 1 |
| Ashkenazi-Hoffnung, L | 1 |
| Merlob, P | 1 |
| Stahl, B | 1 |
| Klinger, G | 1 |
| Niebyl, JR | 1 |
| Briggs, GG | 1 |
| Madjunkova, S | 1 |
| Maltepe, C | 3 |
| Koren, G | 14 |
| Festin, M | 1 |
| Oliveira, LG | 1 |
| Capp, SM | 1 |
| You, WB | 1 |
| Riffenburgh, RH | 1 |
| Carstairs, SD | 1 |
| Clark, S | 3 |
| Hankins, GD | 3 |
| Caritis, SN | 2 |
| Umans, JG | 3 |
| Miodovnik, M | 3 |
| Mattison, DR | 2 |
| Matok, I | 2 |
| Faramarzi, M | 1 |
| Yazdani, S | 1 |
| Barat, S | 1 |
| McParlin, C | 1 |
| O'Donnell, A | 1 |
| Robson, SC | 1 |
| Beyer, F | 1 |
| Moloney, E | 1 |
| Bryant, A | 1 |
| Bradley, J | 1 |
| Muirhead, CR | 1 |
| Nelson-Piercy, C | 1 |
| Newbury-Birch, D | 1 |
| Norman, J | 1 |
| Shaw, C | 1 |
| Simpson, E | 1 |
| Swallow, B | 1 |
| Yates, L | 1 |
| Vale, L | 1 |
| Zhang, R | 1 |
| Persaud, N | 1 |
| Nulman, I | 1 |
| Rovet, J | 1 |
| Barrera, M | 1 |
| Knittel-Keren, D | 1 |
| Feldman, BM | 1 |
| HESSELTINE, HC | 1 |
| Gill, SK | 1 |
| Garcia-Bournissen, F | 2 |
| Costantine, MM | 1 |
| Chiossi, G | 1 |
| Caritis, S | 1 |
| Arsenault, MY | 1 |
| Lane, CA | 1 |
| MacKinnon, CJ | 1 |
| Bartellas, E | 1 |
| Cargill, YM | 1 |
| Klein, MC | 1 |
| Martel, MJ | 1 |
| Sprague, AE | 1 |
| Wilson, AK | 1 |
| Tiran, D | 1 |
| Brent, R | 2 |
| Kutcher, JS | 1 |
| Engle, A | 1 |
| Firth, J | 1 |
| Lamm, SH | 1 |
| NULSEN, RO | 1 |
| TOWNE, JE | 1 |
| BETHEA, RC | 1 |
| DAVIDSON, OL | 1 |
| GEIGER, CJ | 1 |
| FAHRENBACH, DM | 1 |
| HEALEY, FJ | 1 |
| ALEXANDER, CH | 1 |
| DIGGORY, PL | 1 |
| TOMKINSON, JS | 1 |
| RHODES, P | 1 |
| ROSENVASSER, EB | 1 |
| CARPANO, A | 1 |
| WOODHULL, RB | 1 |
| Boskovic, R | 1 |
| Einarson, A | 3 |
| Wolpin, J | 1 |
| Bsat, FA | 1 |
| Hoffman, DE | 1 |
| Seubert, DE | 1 |
| HILL, FW | 1 |
| DORSEY, CW | 1 |
| KERNIS, L | 1 |
| STODSKY, B | 1 |
| MULLA, NP | 1 |
| Staroselsky, A | 1 |
| Pipino, G | 1 |
| Raffaglio, E | 1 |
| DiPalma, JR | 1 |
| Aselton, P | 1 |
| Jick, H | 1 |
| Chentow, SJ | 1 |
| Perera, DR | 1 |
| Hunter, JR | 1 |
| Rothman, KJ | 1 |
| Hays, DP | 1 |
| McCredie, J | 1 |
| Kricker, A | 1 |
| Elliott, J | 1 |
| Forrest, J | 1 |
| Davis, JM | 1 |
| Huff, PS | 1 |
| David, TJ | 1 |
| Cordero, JF | 1 |
| Oakley, GP | 1 |
| Greenberg, F | 1 |
| James, LM | 1 |
| Korcok, M | 1 |
| Vutyavanich, T | 1 |
| Wongtra-ngan, S | 1 |
| Ruangsri, R | 1 |
| Erick, M | 1 |
| Philpot, J | 1 |
| Muntoni, F | 1 |
| Skellett, S | 1 |
| Dubowitz, V | 1 |
| Villegas-Salas, E | 1 |
| Ponce de León, R | 1 |
| Juárez-Perez, MA | 1 |
| Grubb, GS | 1 |
| Aikins Murphy, P | 1 |
| Mahajan, MK | 1 |
| Singh, V | 1 |
| Bailey, B | 1 |
| Sanders, J | 1 |
| Boneva, RS | 1 |
| Moore, CA | 1 |
| Botto, L | 1 |
| Wong, LY | 1 |
| Erickson, JD | 1 |
| Emelianova, S | 1 |
| Mazzotta, P | 3 |
| Navioz, Y | 2 |
| Magee, LA | 2 |
| Bishai, R | 1 |
| Atanackovic, G | 2 |
| Levichek, Z | 1 |
| Pole, M | 1 |
| Meltzer, DI | 1 |
| Moretti, ME | 1 |
| Strong, TH | 1 |
| Allen, R | 1 |
| Fabian, CJ | 1 |
| Rasmussen, S | 1 |
| Stephens, R | 1 |
| Haut, A | 1 |
| Smith, F | 1 |
| Balcerzak, S | 1 |
| Tranum, B | 1 |
| Wheatley, D | 1 |
| Check, WA | 1 |
| Sahakian, V | 1 |
| Rouse, D | 1 |
| Sipes, S | 1 |
| Rose, N | 1 |
| Niebyl, J | 1 |
| Rádi, A | 1 |
| Leathem, AM | 1 |
| Jick, SS | 1 |
| Garrison, JM | 1 |
| Walters, WA | 1 |
| Schuster, K | 1 |
| Bailey, LB | 1 |
| Dimperio, D | 1 |
| Mahan, CS | 1 |
| Elbourne, D | 1 |
| Mutch, L | 1 |
| Dauncey, M | 1 |
| Campbell, H | 1 |
| Samphier, M | 1 |
| Hunter, KR | 1 |
| Stern, GM | 1 |
| Laurence, DR | 2 |
| Carter, AB | 2 |
| Gibson, JP | 1 |
| Staples, RE | 1 |
| Larson, EJ | 1 |
| Kuhn, WL | 1 |
| Holtkamp, DE | 1 |
| Newberne, JW | 1 |
| Stradling, P | 1 |
| Lipman, IJ | 1 |
| McGuinness, BW | 1 |
| Binns, DT | 1 |
| Holt, JA | 1 |
| Bortoletto, S | 1 |
| Mattie, H | 1 |
| Emery, EW | 1 |
| Hill, ID | 1 |
| Sicher, K | 1 |
| Backhouse, TW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prevalence and Burden of Nausea and Vomiting in Pregnant Women in Switzerland: Survey Purity 2022[NCT06055192] | 200 participants (Anticipated) | Observational | 2023-09-30 | Not yet recruiting | |||
| Is Zofran Superior to Pyridoxine at Reducing Nausea and Vomiting in Pregnancy[NCT01668069] | 36 participants (Actual) | Interventional | 2012-10-31 | Completed | |||
| A Double-Blind, Multicenter, Randomized, Placebo-Controlled Trial Of The Efficacy Of Diclectin® For Nausea And Vomiting Of Pregnancy[NCT00614445] | Phase 3 | 280 participants (Actual) | Interventional | 2008-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The objective of this double-blind, randomized, placebo-controlled study was to assess the efficacy, safety, and tolerability of oral Diclectin® in the treatment of nausea and vomiting of pregnancy (NVP) as measured by the Pregnancy Unique-Quantification of Emesis (PUQE) overall score of symptoms from baseline (Day 1) to end of study visit (Day 15). The PUQE score measured hours of nausea, number of times vomiting, and number of times retching for a TOTAL overall score of symptoms on a scale rated from 3 (no symptoms) to 15 (most severe). (NCT00614445)
Timeframe: Baseline (Day 1) to End of Study Visit Day 15 (± 1 day)
| Intervention | PUQE Score (Mean) |
|---|---|
| Diclectin® | -4.8 |
| Placebo | -3.9 |
17 reviews available for pyridoxine and Nausea
| Article | Year |
|---|---|
The effects of pyridoxine (vitamin B6) supplementation in nausea and vomiting during pregnancy: a systematic review and meta-analysis.
Topics: Antiemetics; Dietary Supplements; Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyrido | 2023 |
Nausea and vomiting of pregnancy and hyperemesis gravidarum.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Growth Differentiation Factor 15; H | 2019 |
Misleading meta-analyses of observational studies may generate unjustified alarms: The case of medications for nausea and vomiting in pregnancy.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 2021 |
Doxylamine/pyridoxine for nausea and vomiting in pregnancy.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Practice Guidelines | 2019 |
The pharmacologic management of nausea and vomiting of pregnancy.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Histamine H1 Antagonists; Humans; N | 2014 |
The delayed-release combination of doxylamine and pyridoxine (Diclegis®/Diclectin ®) for the treatment of nausea and vomiting of pregnancy.
Topics: Antiemetics; Delayed-Action Preparations; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 2014 |
Nausea and vomiting in early pregnancy.
Topics: Acupressure; Acupuncture Therapy; Adrenal Cortex Hormones; Antiemetics; Female; Humans; Nausea; Preg | 2014 |
Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review.
Topics: Acupuncture; Adrenal Cortex Hormones; Antiemetics; Doxylamine; Female; Histamine Antagonists; Humans | 2016 |
Nausea and vomiting in pregnancy: safety and efficacy of self-administered complementary therapies.
Topics: Acupressure; Acupuncture Therapy; Attitude to Health; Complementary Therapies; Female; Humans; Mater | 2002 |
Safety of drug therapy for nausea and vomiting of pregnancy.
Topics: Abnormalities, Drug-Induced; Antiemetics; Child; Dicyclomine; Doxylamine; Drug Combinations; Female; | 1980 |
Alternative therapies for nausea and vomiting of pregnancy.
Topics: Acupressure; Complementary Therapies; Female; Humans; Nausea; Phytotherapy; Pregnancy; Pyridoxine; V | 1998 |
Critical appraisal of drug therapy for nausea and vomiting of pregnancy: II. Efficacy and safety of diclectin (doxylamine-B6).
Topics: Antiemetics; Doxylamine; Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Ran | 2000 |
Alternative therapies of morning sickness.
Topics: Acupressure; Antiemetics; Complementary Therapies; Dicyclomine; Doxylamine; Drug Combinations; Femal | 2001 |
Medical, social, and legal implications of treating nausea and vomiting of pregnancy.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 2002 |
Are we failing women? Advice for nausea and vomiting in pregnancy.
Topics: Acupressure; Causality; Female; Humans; Maternal-Child Nursing; Nausea; Nurse Midwives; Nurse's Role | 2001 |
Safety and efficacy of antiemetics used to treat nausea and vomiting in pregnancy.
Topics: Antiemetics; Antipsychotic Agents; Dicyclomine; Diphenhydramine; Doxylamine; Drug Combinations; Fema | 1986 |
L-dopa therapy in Parkinson's disease.
Topics: Delirium; Depression; Dihydroxyphenylalanine; Gastrointestinal Hemorrhage; Hallucinations; Humans; H | 1971 |
17 trials available for pyridoxine and Nausea
| Article | Year |
|---|---|
Acupuncture and Doxylamine-Pyridoxine for Nausea and Vomiting in Pregnancy : A Randomized, Controlled, 2
Topics: Acupuncture Therapy; Antiemetics; Child; Doxylamine; Female; Humans; Nausea; Pregnancy; Pregnancy Co | 2023 |
Ondansetron compared with doxylamine and pyridoxine for treatment of nausea in pregnancy: a randomized controlled trial.
Topics: Adult; Antiemetics; Double-Blind Method; Doxylamine; Drug Therapy, Combination; Female; Follow-Up St | 2014 |
Maternal safety of the delayed-release doxylamine and pyridoxine combination for nausea and vomiting of pregnancy; a randomized placebo controlled trial.
Topics: Adult; Antiemetics; Delayed-Action Preparations; Dicyclomine; Double-Blind Method; Doxylamine; Drug | 2015 |
A RCT of psychotherapy in women with nausea and vomiting of pregnancy.
Topics: Adolescent; Adult; Cognitive Behavioral Therapy; Combined Modality Therapy; Female; Humans; Mindfuln | 2015 |
8-Way Randomized Controlled Trial of Doxylamine, Pyridoxine and Dicyclomine for Nausea and Vomiting during Pregnancy: Restoration of Unpublished Information.
Topics: Cooperative Behavior; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Physicians | 2017 |
Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
Topics: Adult; Delayed-Action Preparations; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Meth | 2010 |
Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
Topics: Adult; Delayed-Action Preparations; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Meth | 2010 |
Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
Topics: Adult; Delayed-Action Preparations; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Meth | 2010 |
Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
Topics: Adult; Delayed-Action Preparations; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Meth | 2010 |
Determinants of adherence to delayed-release doxylamine and pyridoxine in patients with nausea and vomiting of pregnancy.
Topics: Adult; Antiemetics; Cohort Studies; Delayed-Action Preparations; Dicyclomine; Double-Blind Method; D | 2012 |
Comparison of three outpatient regimens in the management of nausea and vomiting in pregnancy.
Topics: Adult; Antiemetics; Drug Therapy, Combination; Female; Humans; Hyperemesis Gravidarum; Metoclopramid | 2003 |
Pyridoxine for nausea and vomiting of pregnancy: a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Antiemetics; Double-Blind Method; Female; Humans; Nausea; Placebos; Pregnancy; Pregnancy Comp | 1995 |
Effect of vitamin B6 on the side effects of a low-dose combined oral contraceptive.
Topics: Adolescent; Adult; Contraceptives, Oral, Combined; Dizziness; Ethinyl Estradiol; Female; Headache; H | 1997 |
Assessment of efficacy of pyridoxine in control of radiation induced sickness.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chemotherapy, Adjuvant; Child; Child, Preschool; Delayed | 1998 |
Phase II evaluation of hexamethylmelamine in advanced breast cancer: a Southwest Oncology Group study.
Topics: Aged; Altretamine; Breast Neoplasms; Drug Evaluation; Female; Humans; Middle Aged; Nausea; Nervous S | 1979 |
Treatment of pregnancy sickness.
Topics: Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Dicyclomine; Double-Blind Method; Doxylamine; | 1977 |
Vitamin B6 is effective therapy for nausea and vomiting of pregnancy: a randomized, double-blind placebo-controlled study.
Topics: Adult; Double-Blind Method; Female; Humans; Nausea; Odds Ratio; Pregnancy; Pregnancy Complications; | 1991 |
'Debendox' in pregnancy sickness.
Topics: Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Female; Humans; Nausea; Parasympatholytics; P | 1971 |
Treatment of radiation sickness with pyridoxine hydrochloride in outpatients of a radiotherapy unit.
Topics: Anorexia Nervosa; Clinical Trials as Topic; Humans; Nausea; Outpatient Clinics, Hospital; Placebos; | 1967 |
An assessment of thiethylperazine (Torecan) in the control of radiation-induced nausea and vomiting.
Topics: Antiemetics; Humans; Nausea; Neoplasms; Pyridoxine; Radiotherapy; Thiethylperazine; Vomiting | 1968 |
69 other studies available for pyridoxine and Nausea
| Article | Year |
|---|---|
Comparative dissolution profiles of two anti-emetic delayed release dosage forms of doxylamine and pyridoxine: Xonvea® tablets vs. Cariban® capsules.
Topics: Antiemetics; Doxylamine; Female; Gastrointestinal Agents; Humans; Nausea; Pregnancy; Pyridoxine; Sol | 2022 |
The association of nausea and vomiting of pregnancy, its treatments, and select birth defects: Findings from the National Birth Defect Prevention Study.
Topics: Cleft Palate; Craniosynostoses; Female; Humans; Microphthalmos; Nausea; Pregnancy; Pregnancy Complic | 2023 |
Bioavailability of Cariban
Topics: Adult; Antiemetics; Biological Availability; Capsules; Delayed-Action Preparations; Doxylamine; Drug | 2023 |
[Interest of vitamin b6 for treatment of nausea and/or vomiting during pregnancy].
Topics: Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Vitamin B 6; Vomiting | 2020 |
Is ginger really effective for the treatment of the first trimester nausea and vomiting?
Topics: Female; Humans; Nausea; Pregnancy; Pregnancy Trimester, First; Pyridoxine; Vitamin B 6; Vomiting; Zi | 2019 |
New evidence for concern over the risk of birth defects from medications for nausea and vomitting of pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Antiemetics; Cohort Studies; Dicyclomine; Doxylamine; Drug Combi | 2019 |
Evaluation of the efficacy and safety of bi-daily combination therapy with pyridoxine and doxylamine for nausea and vomiting of pregnancy.
Topics: Administration, Oral; Adult; Antiemetics; Case-Control Studies; Dicyclomine; Dose-Response Relations | 2013 |
Diclegis for nausea and vomiting of pregnancy.
Topics: Antiemetics; Delayed-Action Preparations; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 2013 |
Long-term neurodevelopment of children exposed to maternal nausea and vomiting of pregnancy and diclectin.
Topics: Adult; Antiemetics; Child; Child Development; Child, Preschool; Cohort Studies; Dicyclomine; Doxylam | 2009 |
FAILURE of pyridoxine therapy in nausea and vomiting of pregnancy.
Topics: Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Vomiting | 1946 |
Pyridoxine failure in nausea and vomiting of pregnancy.
Topics: Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Vomiting | 1946 |
Systemic bioavailability and pharmacokinetics of the doxylamine-pyridoxine delayed-release combination (Diclectin).
Topics: Adult; Antiemetics; Biological Availability; Canada; Delayed-Action Preparations; Dicyclomine; Doxyl | 2011 |
The management of nausea and vomiting of pregnancy.
Topics: Algorithms; Anti-Inflammatory Agents; Antiemetics; Complementary Therapies; Cost of Illness; Decisio | 2002 |
Bendectin and birth defects: hopefully, the final chapter.
Topics: Abnormalities, Drug-Induced; Adult; Adverse Drug Reaction Reporting Systems; Animals; Antiemetics; C | 2003 |
Bendectin and birth defects. II: Ecological analyses.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Adverse Drug Reaction Reporting Systems | 2003 |
Bendectin in the treatment of nausea of pregnancy.
Topics: Dicyclomine; Doxylamine; Drug Combinations; Histamine H1 Antagonists; Muscle Relaxants, Central; Nau | 1957 |
Nausea and vomiting of pregnancy: treatment with bendectin.
Topics: Dicyclomine; Doxylamine; Drug Combinations; Histamine H1 Antagonists; Muscle Relaxants, Central; Nau | 1958 |
Evaluation of a combination of meclizine and pyridoxine in the control of nausea and vomiting in pregnancy.
Topics: Anti-Allergic Agents; Female; Histamine H1 Antagonists; Humans; Hyperemesis Gravidarum; Meclizine; N | 1960 |
Clinical experience with a combination of trimethobenzamide and pyridoxine in patients with nausea and vomiting of pregnancy.
Topics: Antiemetics; Benzamides; Female; Humans; Hyperemesis Gravidarum; Nausea; Pregnancy; Pregnancy Compli | 1960 |
Bendectin in the treatment of nausea and vomiting in pregnancy.
Topics: Dicyclomine; Doxylamine; Drug Combinations; Histamine H1 Antagonists; Muscle Relaxants, Central; Nau | 1959 |
Control of nausea and vomiting of pregnancy with rimethobenzamide and pyridoxine.
Topics: Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Vitamin B 6; Vomiting | 1962 |
Nausea and vomiting in pregnancy. A trial of meclozine dihydrochloride with and without pyridoxine.
Topics: Antiemetics; Female; Humans; Hyperemesis Gravidarum; Meclizine; Nausea; Pregnancy; Pyridoxine; Vomit | 1962 |
HYPEREMESIS GRAVIDARUM.
Topics: Blood Chemical Analysis; Female; Humans; Hyperemesis Gravidarum; Meclizine; Nausea; Pathology; Pregn | 1964 |
[FAINTING AND NAUSEA OF PREGNANCY. ITS THERAPY WITH A COMBINATION OF A NEW POORLY SOLUBLE SALT OF DIPHENHYDRAMINE, SCOPOLAMINE AND PYRIDOXINE].
Topics: Diphenhydramine; Female; Humans; Hyperemesis Gravidarum; Nausea; Pharmacology; Pregnancy; Pyridoxine | 1963 |
AN EFFECTIVE CONTROL OF NAUSEA AND VOMITING IN PREGNANCY.
Topics: Drug Therapy; Female; Humans; Nausea; Pregnancy; Pyridoxine; Toxicology; Vomiting | 1965 |
Diclectin therapy for nausea and vomiting of pregnancy: effects of optimal dosing.
Topics: Adult; Antiemetics; Dose-Response Relationship, Drug; Doxylamine; Drug Combinations; Female; Humans; | 2003 |
Pyridoxine in the treatment of postanaesthetic nausea and vomiting.
Topics: Humans; Nausea; Pyridoxine; Vomiting | 1951 |
The use of pyridoxine and suprarenal cortex combined in the treatment of nausea and vomiting of pregnancy.
Topics: Female; Folic Acid; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Vitamin B Comple | 1949 |
Failure of pyridoxine in post anesthetic nausea and vomiting.
Topics: Anesthesia; Anesthetics; Humans; Nausea; Pyridoxine; Vitamin B 6; Vomiting | 1950 |
EVALUATION OF TRIMETHOBENZAMIDE WITH PYRIDOXINE IN NAUSEA AND VOMITING OF PREGNANCY.
Topics: Benzamides; Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Vomiting | 1963 |
American Gastroenterological Association institute medical position statement on the use of gastrointestinal medication in pregnancy.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Gastrointestinal Agents; Gastrointe | 2007 |
[Treatment of the secondary collateral toxic effects of antiblastic drugs].
Topics: Adrenal Glands; Antineoplastic Agents; Asthenia; Headache; Humans; Hypotension; Nausea; Neoplasms; P | 1967 |
Drugs for nausea and vomiting of pregnancy.
Topics: Ethanolamines; Female; Histamine H1 Antagonists; Humans; Nausea; Phenothiazines; Pregnancy; Pregnanc | 1983 |
Pyloric stenosis and maternal Bendectin exposure.
Topics: Adult; Dicyclomine; Doxylamine; Drug Combinations; Drug Prescriptions; Female; Follow-Up Studies; Hu | 1984 |
Debendox and pregnancy.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Pre | 1984 |
Nausea and vomiting of pregnancy.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Pregnancy; Pregnanc | 1983 |
Bendectin: a case of mourning sickness.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Pregnancy; Pregnanc | 1983 |
The innocent bystander. Doxylamine/dicyclomine/pyridoxine and congenital limb defects.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Dose-Response Relationship, Drug; Doxylamine; | 1984 |
Good-bye, Bendectin, old friend.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Drug Industry; Female; Huma | 1984 |
Debendox does not cause the Poland anomaly.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Antiemetics; Dicyclomine; Doxylamine; Drug Com | 1982 |
Is Bendectin a teratogen?
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Drug Evaluatio | 1981 |
The Bendectin debate.
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Femal | 1980 |
Vitamin B-6 and ginger in morning sickness.
Topics: Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Spices; Vomiting | 1995 |
Congenital symmetrical weakness of the upper limbs resembling brachial plexus palsy: a possible sequel of drug toxicity in first trimester of pregnancy?
Topics: Age of Onset; Antiemetics; Arm; Dermatoglyphics; Diagnosis, Differential; Dicyclomine; Doxylamine; D | 1995 |
Pregnancy outcome of women exposed to pinaverium due to a dispensing error.
Topics: Antiemetics; Calcium Channel Blockers; Canada; Dicyclomine; Doxylamine; Drug Combinations; Female; F | 1999 |
From science to evidence: the testimony on causation in the Bendectin cases.
Topics: Abnormalities, Drug-Induced; Data Collection; Decision Making; Doxylamine; Drug Combinations; Expert | 1993 |
Nausea during pregnancy and congenital heart defects: a population-based case-control study.
Topics: Adolescent; Adult; Antiemetics; Case-Control Studies; Female; Georgia; Heart Defects, Congenital; Hu | 1999 |
Prevalence and severity of nausea and vomiting of pregnancy and effect of vitamin supplementation.
Topics: Canada; Dietary Supplements; Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Prevalence; | 1999 |
Managing women with nausea and vomiting of pregnancy. Canadian consensus.
Topics: Adult; Anti-Inflammatory Agents; Antiemetics; Asthma; Diagnosis, Differential; Doxylamine; Drug Ther | 2000 |
Attitudes, management and consequences of nausea and vomiting of pregnancy in the United States and Canada.
Topics: Adult; Antiemetics; Attitude; Attitude of Health Personnel; Canada; Cost of Illness; Dicyclomine; Di | 2000 |
Appraisal of drug therapy for nausea and vomiting of pregnancy: I. The placebo effect - methodological and practical considerations.
Topics: Female; Humans; Nausea; Placebo Effect; Pregnancy; Pregnancy Complications; Pyridoxine; Randomized C | 2000 |
Selections from current literature. Complementary therapies for nausea and vomiting in early pregnancy.
Topics: Complementary Therapies; Female; Humans; Hyperemesis Gravidarum; Nausea; Phytotherapy; Plants, Medic | 2000 |
The safety of higher than standard dose of doxylamine-pyridoxine (Diclectin) for nausea and vomiting of pregnancy.
Topics: Antiemetics; Doxylamine; Drug Combinations; Female; Humans; Infant, Newborn; Nausea; Pregnancy; Preg | 2001 |
CDC study: no evidence for teratogenicity of Bendectin.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Heart | 1979 |
Congenital deformities associated with Bendectin.
Topics: Abnormalities, Drug-Induced; Adult; Cleft Lip; Cleft Palate; Cyclohexanecarboxylic Acids; Dicyclomin | 1977 |
Torecan, a review of references and clinical control examinations.
Topics: Adolescent; Child; Drug Evaluation; Female; Humans; Male; Nausea; Pregnancy; Pyridoxine; Thiethylper | 1990 |
Discontinuation of Bendectin.
Topics: Adult; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Pregnancy; P | 1988 |
The management of nausea and vomiting during pregnancy.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Legislation, Drug; Nausea; | 1987 |
Morning sickness and vitamin B6 status of pregnant women.
Topics: Adolescent; Adult; Aspartate Aminotransferases; Erythrocytes; Female; Humans; Nausea; Pregnancy; Pre | 1985 |
Debendox revisited.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Drug Com | 1985 |
Use of levodopa with other drugs.
Topics: Adult; Aged; Antidepressive Agents; Antiemetics; Digoxin; Dihydroxyphenylalanine; Diuretics; Drug An | 1970 |
L-dopa. II.
Topics: Anorexia Nervosa; Cardiac Complexes, Premature; Dihydroxyphenylalanine; Drug Synergism; Humans; Hypo | 1970 |
Letter: Pyridoxine contraindicated in parkinsonism.
Topics: Dihydroxyphenylalanine; Drug Antagonism; Humans; Metoclopramide; Nausea; Parkinson Disease; Pyridoxi | 1973 |
Teratology and reproduction studies with an antinauseant.
Topics: Abnormalities, Drug-Induced; Animal Feed; Animals; Birth Weight; Female; Histamine H1 Antagonists; M | 1968 |
Side effects observed during intermittent rifampicin therapy.
Topics: Antibody Formation; Antigen-Antibody Reactions; Drug Therapy, Combination; Fever; Headache; Humans; | 1973 |
Levodopa and related drugs.
Topics: Amantadine; Apomorphine; Dihydroxyphenylalanine; Humans; Hydrazines; Hypotension; Mental Disorders; | 1973 |
Letter: Pyridoxine and Parkinsonism.
Topics: Dihydroxyphenylalanine; Humans; Nausea; Parkinson Disease; Pyridoxine | 1973 |
A trial of thiethylperazine ("Torecan") in patients suffering from radiation sickness.
Topics: Dimenhydrinate; Feeding and Eating Disorders; Humans; Nausea; Neoplasms; Pyridoxine; Radiation Injur | 1965 |
[Evaluation of a combination of antiemetics in cases of nausea and vomiting during pregnancy].
Topics: Adolescent; Adult; Antiemetics; Cyclohexanecarboxylic Acids; Female; Humans; Nausea; Pre-Eclampsia; | 1968 |