pyridoxine and Mental Disorders studies

4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).

Mental Disorders: Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.

Research Excerpts

Excerpt	Relevance	Reference
"Among people with epilepsy, levetiracetam (LEV) can cause neuropsychiatric adverse events (NPAEs) that impact negatively on quality of life."	5.05	Pyridoxine supplementation for levetiracetam-related neuropsychiatric adverse events: A systematic review. ( Perucca, E; Romoli, M; Sen, A, 2020)
" This review summarises that available pharmacokinetic data involving levodopa, especially as it relates to therapeutic response of parkinsonian patients."	2.35	Clinical pharmacokinetics of levodopa in parkinson's disease. ( Bianchine, JR; Shaw, GM, 1976)
"A treatment with Pyridoxine and Pramipexole was prescribed, but never started because she died."	1.48	When dysphoria is not a primary mental state: A case report of the role of the aromatic L-aminoacid decarboxylase. ( Bramanti, P; Cammaroto, S; Fraggetta, F; Gugliandolo, A; Leonardi, S; Mazzon, E; Morabito, R; Portaro, S; Scionti, D, 2018)
"As mental illness is often chronic and recurrent, requiring long-term drug therapy, it is important to become aware of the effects of drugs and their possible interactions with other important factors such as food."	1.27	Diet and drug interactions in the treatment of mental illness--a review. ( Awad, AG, 1984)

Timeframe	Studies, this research(%)	All Research%
pre-1990	36 (83.72)	18.7374
1990's	4 (9.30)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (2.33)	24.3611
2020's	2 (4.65)	2.80

Authors	Studies
Sofyan, M	1
Fitriani, DY	1
Friska, D	1
Basrowi, RW	1
Fuady, A	1
Romoli, M	1
Perucca, E	1
Sen, A	1
Portaro, S	1
Gugliandolo, A	1
Scionti, D	1
Cammaroto, S	1
Morabito, R	1
Leonardi, S	1
Fraggetta, F	1
Bramanti, P	1
Mazzon, E	1
CELICE, J	1
PLAS, F	1
DUCHESNAY, G	2
LEMONNIER, F	1
FEITELEVICH, J	2
ZIPILIVAN, M	1
MORRONI, OB	1
VERGA, G	1
MOLINA, C	1
ERLANDE, G	1
DILLE, JR	1
SMITH, PW	1
HARTMANN-VONMONAKOW, K	1
MARGAT, MM	1
HEELEY, AF	1
ROBERTS, GE	1
Awad, AG	1
Gualtieri, CT	1
Golden, RN	1
Fahs, JJ	1
Dennerstein, L	1
Spencer-Gardner, C	1
Burrows, GD	1
Poon, WS	1
Ahuja, A	1
Li, AK	1
Massé, PG	1
Van den Berg, H	1
Livingstone, MM	1
Duguay, C	1
Beaulieu, G	1
Campanini, T	1
Catalano, A	1
De Risio, C	1
Forino, V	1
Dickerson, JW	1
Wiryanti, J	1
Gonce, M	1
Barbeau, A	1
Bianchine, JR	1
Shaw, GM	1
Bell, IR	1
Morrow, FD	1
Read, M	1
Berkes, S	1
Perrone, G	1
Kleijnen, J	1
Knipschild, P	1
Carboni, MA	1
Corsa, R	1
Hancock, MR	1
Hullin, RP	1
Aylard, PR	1
King, JR	1
Morgan, DB	1
Clerens, J	1
Bleandonu, G	1
Boye, J	1
Soulairac, A	2
Aymard, N	2
Dalle, B	2
Agostini, L	1
Kaeser, HE	1
Ferel, D	1
Wurmser, P	1
Stein, SI	1
Sprince, H	1
Pauling, L	1
Tibaldeschi, C	1
Novelli, F	1
Ercoli, A	1
Duè, G	1
Kaeser, AC	1
Rodnight, R	1
Ellis, BA	1
Barberini, E	1

Article	Year
Pyridoxine supplementation for levetiracetam-related neuropsychiatric adverse events: A systematic review. Epilepsy & behavior : E&B, 2020, Volume: 103, Issue:Pt A Topics: Anticonvulsants; Diagnostic Tests, Routine; Dietary Supplements; Drug Therapy, Combination; Epilepsy	2020
[PYRIDOXINE IN THE PATHOGENESIS AND THERAPY OF NEUROLOGIC AND PSYCHIATRIC DISEASES]. Acta vitaminologica, 1963, Volume: 17 Topics: Alcoholism; Brain Diseases; Chorea; Extrapyramidal Tracts; Genetics, Medical; Humans; Intellectual D	1963
New developments in pediatric psychopharmacology. Journal of developmental and behavioral pediatrics : JDBP, 1983, Volume: 4, Issue:3 Topics: Adolescent; Adult; Aggression; Anorexia Nervosa; Antidepressive Agents, Tricyclic; Autistic Disorder	1983
Mood and the menstrual cycle. Journal of psychiatric research, 1984, Volume: 18, Issue:1 Topics: Adult; Aldosterone; Emotions; Estrogens; Female; Gender Identity; Humans; Menstruation; Mental Disor	1984
[The current treatment of Parkinson's disease]. Revue medicale de Liege, 1976, Oct-10, Volume: 31, Issue:19 Topics: Amantadine; Antidepressive Agents, Tricyclic; Dihydroxyphenylalanine; Drug Combinations; Histamine A	1976
Clinical pharmacokinetics of levodopa in parkinson's disease. Clinical pharmacokinetics, 1976, Volume: 1, Issue:5 Topics: Carboxy-Lyases; Cardiovascular Diseases; Dopamine; Dose-Response Relationship, Drug; Dyskinesia, Dru	1976
Niacin and vitamin B6 in mental functioning: a review of controlled trials in humans. Biological psychiatry, 1991, May-01, Volume: 29, Issue:9 Topics: Adult; Autistic Disorder; Child; Clinical Trials as Topic; Down Syndrome; Humans; Mental Disorders;	1991
[The importance of pyridoxine in the pathology of the nervous system. Review of literature and experimental results of vitamin B 6 deficiency in the rat]. Rivista sperimentale di freniatria e medicina legale delle alienazioni mentali, 1967, Apr-03, Volume: 91, Issue:2 Topics: Animals; Humans; Mental Disorders; Nervous System Diseases; Pyridoxine; Rats; Vitamin B 6 Deficiency	1967

Article	Year
B Vitamins, work-related stress and emotional mental disorders: a cross-sectional study among nurses in Indonesia. Nursing open, 2022, Volume: 9, Issue:4 Topics: Cross-Sectional Studies; Humans; Indonesia; Mental Disorders; Occupational Stress; Pyridoxine; Thiam	2022
When dysphoria is not a primary mental state: A case report of the role of the aromatic L-aminoacid decarboxylase. Medicine, 2018, Volume: 97, Issue:22 Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Aromatic-L-Amino-Acid Decarboxylases; Benzo	2018
[Effect of cocarboxylase and pyridoxol (vitamin B6) in large doses on certain heart diseases connected with stress]. Therapie, 1957, Volume: 12, Issue:4 Topics: Cardiotonic Agents; Diuretics; Heart Diseases; Humans; Mental Disorders; Pyridoxine; Thiamine Pyroph	1957
[New uses of pyridoxine or vitamin B6]. Semaine medicale professionelle et medico-sociale, 1958, Oct-20, Volume: 34, Issue:36 Topics: Disease; Heart Diseases; Mental Disorders; Neuritis; Optic Nerve; Optic Nerve Diseases; Psychoses, A	1958
[gamma-Aminobutyric acid-pyridoxine in the treatment of states of irritability and connected nervous disorders]. La Semana medica, 1962, Apr-16, Volume: 120 Topics: Amino Acids; gamma-Aminobutyric Acid; Irritable Mood; Mental Disorders; Nervous System Diseases; Neu	1962
[Effects of gamma-aminobutyric acid-pyridoxine in presenile and senile psychiatric disorders]. La Semana medica, 1962, Dec-31, Volume: 121 Topics: Amino Acids; Dementia; gamma-Aminobutyric Acid; Humans; Mental Disorders; Psychotic Disorders; Pyrid	1962
[IMMEDIATE CLINICAL RESULTS WITH GAMMA AMINOBUTYRIC ACID B6 IN SCHIZOPHRENIAS AND DELIRIUMS]. La Semana medica, 1963, Sep-16, Volume: 123 Topics: Aminobutyrates; Biochemical Phenomena; Biochemistry; Delirium; gamma-Aminobutyric Acid; Mental Disor	1963
[VITAMIN B DEFICIENCIES IN PULMONARY TUBERCULOUS PATIENTS TREATED BY ANTIBACILLARY MEDICATIONS]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1963, May-08, Volume: 39 Topics: Aspartate Aminotransferases; Clinical Enzyme Tests; Dermatology; Diagnosis; Gynecomastia; Humans; Is	1963
[CLINICAL AND THERAPEUTIC STUDY OF A NEW BI-VITAMIN BIOCHEMICAL MOLECULE]. Marseille medical, 1964, Volume: 101 Topics: Anemia; Arteriosclerosis; Ascorbic Acid; Humans; Intracranial Arteriosclerosis; Liver Diseases; Ment	1964
CENTRAL NERVOUS SYSTEM EFFECTS OF CHRONIC EXPOSURE TO ORGANOPHOSPHATE INSECTICIDES. Aerospace medicine, 1964, Volume: 35 Topics: Agricultural Workers' Diseases; Alcoholic Beverages; Atropine; Central Nervous System Diseases; Conv	1964
[PYRITHIOXINE MANAGEMENT OF NEUROPSYCHIATRIC ASPECTS]. Schweizerische medizinische Wochenschrift, 1964, Jul-25, Volume: 94 Topics: Brain Diseases; Disease Management; Drug Therapy; Humans; Mental Disorders; Pyridoxine; Pyrithioxin	1964
[A MULTIPLE TISSUE EXTRACT (PAT) AS BASIC MEDICATION FOR ALCOHOLIC DETOXICATION CURES]. Clinique (Paris, France), 1964, Volume: 59 Topics: Alcoholism; Ascorbic Acid; Brain; Corrinoids; Drug Therapy; Humans; Liver Extracts; Mental Disorders	1964
TRYPTOPHAN METABOLISM IN PSYCHOTIC CHILDREN. A PRELIMINARY REPORT. Developmental medicine and child neurology, 1965, Volume: 7 Topics: Amino Acids; Child; Humans; Hydrolases; Kynurenine; Mental Disorders; Psychotic Disorders; Pyridoxin	1965
Diet and drug interactions in the treatment of mental illness--a review. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1984, Volume: 29, Issue:7 Topics: Antidepressive Agents, Tricyclic; Antipsychotic Agents; Appetite; Coffee; Diet; Drug Interactions; D	1984
Optochiasmatic tuberculoma causing progressive visual failure: when has medical treatment failed? Postgraduate medical journal, 1993, Volume: 69, Issue:808 Topics: Child, Preschool; Dexamethasone; Drug Therapy, Combination; Female; Humans; Isoniazid; Mental Disord	1993
Nutritional and psychological status of young women after a short-term use of a triphasic contraceptive steroid preparation. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 1998, Volume: 68, Issue:3 Topics: Adult; Contraceptives, Oral; Ethinyl Estradiol-Norgestrel Combination; Female; Ferritins; Humans; Me	1998
[Tardive dyskinesia. Synthetic-critical review and case contribution]. L'Ateneo parmense. Acta bio-medica : organo della Societa di medicina e scienze naturali di Parma, 1977, Volume: 48, Issue:1 Topics: Adult; Aged; Baclofen; Dyskinesia, Drug-Induced; Female; Humans; Iatrogenic Disease; Male; Mental Di	1977
Pellagra and mental disturbance. The Proceedings of the Nutrition Society, 1978, Volume: 37, Issue:2 Topics: Animals; Brain; Diet; Hartnup Disease; Humans; Mental Disorders; Nicotinic Acids; Pellagra; Pyridoxi	1978
Low thyroxine levels in female psychiatric inpatients with riboflavin deficiency: implications for folate-dependent methylation. Acta psychiatrica Scandinavica, 1992, Volume: 85, Issue:5 Topics: Adult; Female; Folic Acid; Folic Acid Deficiency; Hospitalization; Humans; Male; Mental Disorders; M	1992
[Therapeutic use of metadoxine in alcohol-related mental and behavioral disorders]. La Clinica terapeutica, 1987, Dec-31, Volume: 123, Issue:6 Topics: Adult; Aged; Alcoholism; Drug Combinations; Drug Evaluation; Drug Therapy, Combination; Female; Huma	1987
Nutritional state of elderly women on admission to mental hospital. The British journal of psychiatry : the journal of mental science, 1985, Volume: 147 Topics: Aged; Ascorbic Acid; Avitaminosis; Body Weight; Dementia; Dietary Proteins; Female; Humans; Mental D	1985
L-dopa. II. British medical journal, 1970, Nov-28, Volume: 4, Issue:5734 Topics: Anorexia Nervosa; Cardiac Complexes, Premature; Dihydroxyphenylalanine; Drug Synergism; Humans; Hypo	1970
[Problem in psychogeriatrics: quantitative and qualitative cerebral circulation insufficiencies in geriatric medicine]. Zeitschrift fur Alternsforschung, 1971, Volume: 24, Issue:1 Topics: Aged; Aging; Cerebrovascular Disorders; Dietary Proteins; Glucose; Hemodynamics; Humans; Infections;	1971
[Neuropsychiatric incidences in antitubercular treatment consisting of isoniazid or isoniazid and ethionamide (8 cases)]. Annales medico-psychologiques, 1969, Volume: 127, Issue:2 Topics: Acidosis; Adult; Alcoholism; Ammonia; Avitaminosis; Carboxy-Lyases; Chromatography, Paper; Chromatog	1969
[Dynamic exploration of alcohol ingestion in alcoholics with mental diseases]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1972, Feb-26, Volume: 48, Issue:10 Topics: Administration, Oral; Adult; Alcoholism; Capillaries; Ethanol; Humans; Liver Extracts; Male; Mental	1972
[Study of diuresis in alcoholics with mental disorders]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1972, Feb-26, Volume: 48, Issue:10 Topics: Alcoholism; Diuresis; Ethanol; Humans; Mental Disorders; Psychoses, Alcoholic; Pyridoxine; Sodium Ch	1972
Megavitamin and orthomolecular therapy in psychiatry. Nutrition reviews, 1974, Volume: 32, Issue:0 Topics: Aged; Alcoholism; Ascorbic Acid; Avitaminosis; Child; Dose-Response Relationship, Drug; Evaluation S	1974
Levodopa and related drugs. The Medical letter on drugs and therapeutics, 1973, Mar-02, Volume: 15, Issue:5 Topics: Amantadine; Apomorphine; Dihydroxyphenylalanine; Humans; Hydrazines; Hypotension; Mental Disorders;	1973
[Treatment of Parkinson's syndrome with L-dopa]. Schweizerische medizinische Wochenschrift, 1970, May-09, Volume: 100, Issue:19 Topics: Aged; Anti-Bacterial Agents; Anti-Infective Agents, Urinary; Antihypertensive Agents; Barbiturates;	1970
Some observations on pyridoxine and L-tryptophan in a neuropsychiatric medicinal regimen. Annals of the New York Academy of Sciences, 1969, Sep-30, Volume: 166, Issue:1 Topics: Humans; Mental Disorders; Pyridoxine; Tryptophan	1969
An appraisal of methionine-tryptophan interrelationships in mental illness: methylation reactions involved. Biological psychiatry, 1970, Volume: 2, Issue:2 Topics: Animals; Humans; Mental Disorders; Methionine; Methylation; Pyridoxine; Rats; Tryptophan	1970
Orthomolecular psychiatry. Varying the concentrations of substances normally present in the human body may control mental disease. Science (New York, N.Y.), 1968, Apr-19, Volume: 160, Issue:3825 Topics: Aminobenzoates; Biological Evolution; Blood-Brain Barrier; Brain; Brain Diseases; Culture Media; Die	1968
[The use of a drug association in the treatment of concussive syndromes]. La Clinica terapeutica, 1968, Sep-15, Volume: 46, Issue:5 Topics: Adenine Nucleotides; Adenosine Triphosphate; Adolescent; Adult; Aged; Brain Concussion; Child; Heada	1968
Psychiatric and biochemical aspects of a case of homocystinuria. Journal of neurology, neurosurgery, and psychiatry, 1969, Volume: 32, Issue:2 Topics: Adult; Cystine; Female; Homocystinuria; Humans; Male; Mental Disorders; Methionine; Middle Aged; Ped	1969
[Therapeutic experiences with vitamin B 6 in collateral effects due to monoamine oxidase inhibitors]. La Clinica terapeutica, 1966, Jan-15, Volume: 36, Issue:1 Topics: Adult; Aged; Humans; Mental Disorders; Middle Aged; Phenelzine; Pyridoxine; Vitamin B 6 Deficiency	1966

pyridoxine and Mental Disorders

Research Excerpts

Research

Studies (43)

Authors

Reviews

Trials

Other Studies