pyridoxine has been researched along with Hypoxia-Ischemia, Brain in 10 studies
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
Hypoxia-Ischemia, Brain: A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To study the epidemiology of pyridoxine dependent seizures and other forms of pyridoxine responsive seizures." | 7.70 | Epidemiology of pyridoxine dependent and pyridoxine responsive seizures in the UK. ( Baxter, P, 1999) |
| " A dramatic therapeutic response to pyridoxine was observed in the only patient who still had active seizures when starting treatment, while in all three patients interictal EEG discharges and background activity improved after pyridoxine treatment was initiated." | 3.85 | Pyridoxine-5'-phosphate oxidase (Pnpo) deficiency: Clinical and biochemical alterations associated with the C.347g>A (P.·Arg116gln) mutation. ( Carducci, C; Contestabile, R; di Salvo, ML; Guerrini, R; Leuzzi, V; Mastrangelo, M; Mei, D; Montomoli, M; Nogués, I; Paiardini, A; Tolve, M; Tramonti, A, 2017) |
| "To determine whether patients with pyridoxine-responsive seizures but normal biomarkers for antiquitin deficiency and normal sequencing of the ALDH7A1 gene may have PNPO mutations." | 3.80 | Pyridoxine responsiveness in novel mutations of the PNPO gene. ( Abela, L; Clayton, P; Connolly, M; Hasselmann, O; Hofer, D; Kanz, S; Maier, O; Mills, P; Paschke, E; Paul, K; Plecko, B; Schmiedel, G; Stockler, S; Struys, E; Wolf, N, 2014) |
| "To study the epidemiology of pyridoxine dependent seizures and other forms of pyridoxine responsive seizures." | 3.70 | Epidemiology of pyridoxine dependent and pyridoxine responsive seizures in the UK. ( Baxter, P, 1999) |
| "Among these, pyridoxine-dependent seizures due to antiquitin deficiency is by far the most common, although exact incidence data are lacking." | 2.49 | Pyridoxine and pyridoxalphosphate-dependent epilepsies. ( Plecko, B, 2013) |
| "About 7/18 (39%) of patients showed seizure-free with pyridoxine (PN) or pyridoxal-5'-phosphate treatment." | 1.91 | Analysis for variable manifestations and molecular characteristics of pyridox(am)ine-5'-phosphate oxidase (PNPO) deficiency. ( Gong, P; Jiao, X; Niu, Y; Xu, Z; Yang, Z; Zhang, Y, 2023) |
| "Seizures are typically not responsive to conventional antiepileptic drugs, but they cease after parental pyridoxine administration." | 1.46 | Pyridoxine dependent epilepsies: new therapeutical point of view. ( Corsello, G; Falsaperla, R, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (80.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jiao, X | 1 |
| Gong, P | 1 |
| Niu, Y | 1 |
| Xu, Z | 1 |
| Zhang, Y | 1 |
| Yang, Z | 1 |
| Garcia-Ezquiaga, J | 1 |
| Carrasco-Marina, ML | 1 |
| Gutierrez-Cruz, N | 1 |
| Iglesias-Escalera, G | 1 |
| Castro-Reguera, M | 1 |
| Perez-Gonzalez, B | 1 |
| Lopez-Marin, L | 1 |
| Falsaperla, R | 1 |
| Corsello, G | 1 |
| di Salvo, ML | 1 |
| Mastrangelo, M | 1 |
| Nogués, I | 1 |
| Tolve, M | 1 |
| Paiardini, A | 1 |
| Carducci, C | 1 |
| Mei, D | 1 |
| Montomoli, M | 1 |
| Tramonti, A | 1 |
| Guerrini, R | 1 |
| Contestabile, R | 1 |
| Leuzzi, V | 1 |
| Plecko, B | 2 |
| Pearl, PL | 1 |
| Gospe, SM | 1 |
| Paul, K | 1 |
| Mills, P | 1 |
| Clayton, P | 1 |
| Paschke, E | 1 |
| Maier, O | 1 |
| Hasselmann, O | 1 |
| Schmiedel, G | 1 |
| Kanz, S | 1 |
| Connolly, M | 1 |
| Wolf, N | 1 |
| Struys, E | 1 |
| Stockler, S | 1 |
| Abela, L | 1 |
| Hofer, D | 1 |
| Ware, TL | 1 |
| Pitt, J | 1 |
| Freeman, J | 1 |
| Baxter, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Standardized Evaluation of Long-term Neurocognitive Development of Children From Age 3 With Pyridoxine Dependent Epilepsy by Antiquitine Deficiency[NCT06054347] | 30 participants (Anticipated) | Observational | 2023-11-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for pyridoxine and Hypoxia-Ischemia, Brain
| Article | Year |
|---|---|
[Metabolic approach in epileptic encephalopathies in infants].
Topics: Age of Onset; Biotin; Brain Diseases, Metabolic; Brain Diseases, Metabolic, Inborn; Child, Preschool | 2017 |
Pyridoxine and pyridoxalphosphate-dependent epilepsies.
Topics: Brain Diseases, Metabolic; Child; Epilepsy; Humans; Hypoxia-Ischemia, Brain; Pyridoxaminephosphate O | 2013 |
8 other studies available for pyridoxine and Hypoxia-Ischemia, Brain
| Article | Year |
|---|---|
Analysis for variable manifestations and molecular characteristics of pyridox(am)ine-5'-phosphate oxidase (PNPO) deficiency.
Topics: Brain Diseases, Metabolic; Humans; Hypoxia-Ischemia, Brain; Metabolic Diseases; Oxidoreductases; Pho | 2023 |
[Pyridoxine-dependent epilepsy due to deficiency in the PNPO gene].
Topics: Adolescent; Brain Diseases, Metabolic; Chromosomes, Human, Pair 17; Epilepsy; Female; Humans; Hypoxi | 2019 |
Pyridoxine dependent epilepsies: new therapeutical point of view.
Topics: Anticonvulsants; Brain Diseases, Metabolic; Child, Preschool; Electroencephalography; Epilepsy; Fema | 2017 |
Pyridoxine-5'-phosphate oxidase (Pnpo) deficiency: Clinical and biochemical alterations associated with the C.347g>A (P.·Arg116gln) mutation.
Topics: Brain Diseases, Metabolic; Child, Preschool; Female; Humans; Hypoxia-Ischemia, Brain; Infant; Male; | 2017 |
Pyridoxine or pyridoxal-5'-phosphate for neonatal epilepsy: the distinction just got murkier.
Topics: Animals; Brain Diseases, Metabolic; DNA Mutational Analysis; Female; Humans; Hypoxia-Ischemia, Brain | 2014 |
Pyridoxine responsiveness in novel mutations of the PNPO gene.
Topics: Aldehyde Dehydrogenase; Alleles; Animals; Brain Diseases, Metabolic; CHO Cells; Chromosome Deletion; | 2014 |
Pyridoxine responsiveness in novel mutations of the PNPO gene.
Topics: Animals; Brain Diseases, Metabolic; DNA Mutational Analysis; Female; Humans; Hypoxia-Ischemia, Brain | 2015 |
Epidemiology of pyridoxine dependent and pyridoxine responsive seizures in the UK.
Topics: Adolescent; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Hypoxia-Ischemia, Brain; Inc | 1999 |