pyridoxine and Hyperemesis Gravidarum studies

4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).

Hyperemesis Gravidarum: Intractable VOMITING that develops in early PREGNANCY and persists. This can lead to DEHYDRATION and WEIGHT LOSS.

Research Excerpts

Excerpt	Relevance	Reference
"Our investigation showed ondansetron to be superior to the combination of pyridoxine and doxylamine in the treatment of nausea and emesis in pregnancy."	9.19	Ondansetron compared with doxylamine and pyridoxine for treatment of nausea in pregnancy: a randomized controlled trial. ( Capp, SM; Carstairs, SD; Oliveira, LG; Riffenburgh, RH; You, WB, 2014)
"To evaluate oral pyridoxine in conjunction with standard therapy in women hospitalized for hyperemesis gravidarum (HG)."	9.14	A placebo-controlled trial of oral pyridoxine in hyperemesis gravidarum. ( Omar, SZ; Tan, PC; Yow, CM, 2009)
"Our investigation showed ondansetron to be superior to the combination of pyridoxine and doxylamine in the treatment of nausea and emesis in pregnancy."	5.19	Ondansetron compared with doxylamine and pyridoxine for treatment of nausea in pregnancy: a randomized controlled trial. ( Capp, SM; Carstairs, SD; Oliveira, LG; Riffenburgh, RH; You, WB, 2014)
"To evaluate oral pyridoxine in conjunction with standard therapy in women hospitalized for hyperemesis gravidarum (HG)."	5.14	A placebo-controlled trial of oral pyridoxine in hyperemesis gravidarum. ( Omar, SZ; Tan, PC; Yow, CM, 2009)
"This study compares pyridoxine-metoclopramide combination therapy to prochlorperazine and promethazine monotherapies in the outpatient treatment of nausea and vomiting in pregnancy."	5.10	Comparison of three outpatient regimens in the management of nausea and vomiting in pregnancy. ( Bsat, FA; Hoffman, DE; Seubert, DE, 2003)
"For mild symptoms of nausea and emesis of pregnancy, ginger, pyridoxine, antihistamines, and metoclopramide were associated with greater benefit than placebo."	4.93	Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review. ( Beyer, F; Bradley, J; Bryant, A; McParlin, C; Moloney, E; Muirhead, CR; Nelson-Piercy, C; Newbury-Birch, D; Norman, J; O'Donnell, A; Robson, SC; Shaw, C; Simpson, E; Swallow, B; Vale, L; Yates, L, 2016)
"Hyperemesis gravidarum is a severe form of nausea and vomiting in pregnancy affecting 0."	2.53	Interventions for treating hyperemesis gravidarum. ( Barton, SJ; Berghella, V; Boelig, RC; Edwards, SJ; Kelly, AJ; Saccone, G, 2016)
"Of note, co-existing gastroesophageal reflux disease (GERD), Helicobacter pylori infection, and psychosocial factors may have a negative impact on the management of NVP."	2.50	The outpatient management and special considerations of nausea and vomiting in pregnancy. ( Clark, SM; Dutta, E; Hankins, GD, 2014)
"Early pregnancy is characterized by nausea and vomiting which are the most frequent symptoms and the main reason for consulting the physician."	2.41	[Evaluation and treatment of hyperemesis gravidarum]. ( Accorsi, P; Aguzzoli, L; Carossino, E; Crotti, M; Gargano, G; Masellis, G, 2001)

Timeframe	Studies, this research(%)	All Research%
pre-1990	25 (55.56)	18.7374
1990's	2 (4.44)	18.2507
2000's	8 (17.78)	29.6817
2010's	10 (22.22)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Fejzo, MS	1
Trovik, J	1
Grooten, IJ	1
Sridharan, K	1
Roseboom, TJ	1
Vikanes, Å	1
Painter, RC	1
Mullin, PM	1
Sharifzadeh, F	1
Kashanian, M	1
Koohpayehzadeh, J	1
Rezaian, F	1
Sheikhansari, N	1
Eshraghi, N	1
Oliveira, LG	1
Capp, SM	1
You, WB	1
Riffenburgh, RH	1
Carstairs, SD	1
Clark, SM	1
Dutta, E	1
Hankins, GD	1
Festin, M	1
Boelig, RC	1
Barton, SJ	1
Saccone, G	1
Kelly, AJ	1
Edwards, SJ	1
Berghella, V	1
McParlin, C	1
O'Donnell, A	1
Robson, SC	1
Beyer, F	1
Moloney, E	1
Bryant, A	1
Bradley, J	1
Muirhead, CR	1
Nelson-Piercy, C	1
Newbury-Birch, D	1
Norman, J	1
Shaw, C	1
Simpson, E	1
Swallow, B	1
Yates, L	1
Vale, L	1
Pimlott, N	1
Kvern, B	1
Woollard, R	1
Tan, PC	2
Yow, CM	1
Omar, SZ	2
Niebyl, JR	2
Arsenault, MY	1
Lane, CA	1
MacKinnon, CJ	1
Bartellas, E	1
Cargill, YM	1
Klein, MC	1
Martel, MJ	1
Sprague, AE	1
Wilson, AK	1
BALESTRI, F	1
BETHEA, RC	1
DAVIDSON, OL	1
DIGGORY, PL	1
TOMKINSON, JS	1
ROJO, AA	1
RHODES, P	1
PRICE, JJ	1
BARRY, MC	1
VULKOV, T	1
SLAVOV, I	1
ROSENVASSER, EB	1
CARPANO, A	1
PASQUINUCCI, C	1
COLOMBINO, C	1
Bsat, FA	1
Hoffman, DE	1
Seubert, DE	1
Jewell, D	1
Koren, G	1
Maltepe, C	1
Beaton, JG	1
Mitchell, AA	1
Schwingl, PJ	1
Rosenberg, L	1
Louik, C	1
Shapiro, S	1
Linehan, SJ	1
Meltzer, DI	1
Strong, TH	1
Crotti, M	1
Aguzzoli, L	1
Carossino, E	1
Accorsi, P	1
Gargano, G	1
Masellis, G	1
Check, WA	1
Milkovich, L	1
van den Berg, BJ	1
Gant, H	2
Reinken, L	2
Dapunt, O	1
Scholz, K	1
Munro, CD	1
Zierler, S	1
Rothman, KJ	1
Wesel, S	1
Zucconi, G	1
Pannuti, P	1
Pacilli, L	1
Than, N	2
Kóbor, J	2
Tóth, E	2
Najar Origel, S	1

Trial	Enrollment	Study Type	Start Date	Status
Prevalence and Burden of Nausea and Vomiting in Pregnant Women in Switzerland: Survey Purity 2022[NCT06055192]	200 participants (Anticipated)	Observational	2023-09-30	Not yet recruiting
Is Zofran Superior to Pyridoxine at Reducing Nausea and Vomiting in Pregnancy[NCT01668069]	36 participants (Actual)	Interventional	2012-10-31	Completed
The Effect of Adjuvant Hypnosis Added to Conventional Therapy on Nausea and Vomiting in Hyperemesis Gravidarum: A Prospective Randomized Study[NCT04828967]	41 participants (Actual)	Interventional	2017-01-01	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Nausea and vomiting of pregnancy and hyperemesis gravidarum. Nature reviews. Disease primers, 2019, 09-12, Volume: 5, Issue:1 Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Growth Differentiation Factor 15; H	2019
The outpatient management and special considerations of nausea and vomiting in pregnancy. Seminars in perinatology, 2014, Volume: 38, Issue:8 Topics: Ambulatory Care; Antiemetics; Diet Therapy; Doxylamine; Female; Fluid Therapy; Gastroesophageal Refl	2014
Interventions for treating hyperemesis gravidarum. The Cochrane database of systematic reviews, 2016, May-11, Issue:5 Topics: Acupuncture Therapy; Adrenal Cortex Hormones; Antiemetics; Female; Humans; Hydrocortisone; Hyperemes	2016
Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review. JAMA, 2016, 10-04, Volume: 316, Issue:13 Topics: Acupuncture; Adrenal Cortex Hormones; Antiemetics; Doxylamine; Female; Histamine Antagonists; Humans	2016
Clinical practice. Nausea and vomiting in pregnancy. The New England journal of medicine, 2010, Oct-14, Volume: 363, Issue:16 Topics: Adult; Chorionic Gonadotropin; Complementary Therapies; Diagnosis, Differential; Dicyclomine; Doxyla	2010
Contemporary approaches to hyperemesis during pregnancy. Current opinion in obstetrics & gynecology, 2011, Volume: 23, Issue:2 Topics: Adrenal Cortex Hormones; Antiemetics; Diet; Doxylamine; Female; Humans; Hyperemesis Gravidarum; Obst	2011
Nausea and vomiting in early pregnancy. Clinical evidence, 2003, Issue:9 Topics: Acupressure; Acupuncture Therapy; Adrenal Cortex Hormones; Female; Histamine H1 Antagonists; Humans;	2003
Alternative therapies of morning sickness. Clinical obstetrics and gynecology, 2001, Volume: 44, Issue:4 Topics: Acupressure; Antiemetics; Complementary Therapies; Dicyclomine; Doxylamine; Drug Combinations; Femal	2001
[Evaluation and treatment of hyperemesis gravidarum]. Minerva ginecologica, 2001, Volume: 53, Issue:6 Topics: Administration, Oral; Adult; Antiemetics; Birth Weight; Chlorpromazine; Diagnosis, Differential; Fem	2001

Article	Year
A comparison between the effects of ginger, pyridoxine (vitamin B6) and placebo for the treatment of the first trimester nausea and vomiting of pregnancy (NVP). The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2018, Volume: 31, Issue:19 Topics: Adult; Female; Humans; Hyperemesis Gravidarum; Phytotherapy; Plant Preparations; Pregnancy; Pregnanc	2018
Ondansetron compared with doxylamine and pyridoxine for treatment of nausea in pregnancy: a randomized controlled trial. Obstetrics and gynecology, 2014, Volume: 124, Issue:4 Topics: Adult; Antiemetics; Double-Blind Method; Doxylamine; Drug Therapy, Combination; Female; Follow-Up St	2014
A placebo-controlled trial of oral pyridoxine in hyperemesis gravidarum. Gynecologic and obstetric investigation, 2009, Volume: 67, Issue:3 Topics: Adult; Antiemetics; Drug Therapy, Combination; Female; Humans; Hyperemesis Gravidarum; Metoclopramid	2009
Comparison of three outpatient regimens in the management of nausea and vomiting in pregnancy. Journal of perinatology : official journal of the California Perinatal Association, 2003, Volume: 23, Issue:7 Topics: Adult; Antiemetics; Drug Therapy, Combination; Female; Humans; Hyperemesis Gravidarum; Metoclopramid	2003
Pre-emptive therapy for severe nausea and vomiting of pregnancy and hyperemesis gravidarum. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2004, Volume: 24, Issue:5 Topics: Adult; Antiemetics; Dicyclomine; Doxylamine; Drug Administration Schedule; Drug Combinations; Female	2004
An evaluation of the teratogenicity of certain antinauseant drugs. American journal of obstetrics and gynecology, 1976, May-15, Volume: 125, Issue:2 Topics: Abnormalities, Drug-Induced; Antiemetics; Clinical Trials as Topic; Cyclizine; Dicyclomine; Doxylami	1976

pyridoxine and Hyperemesis Gravidarum

Research Excerpts

Research

Studies (45)

Authors

Clinical Trials (3)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Nausea and Vomiting in Early Pregnancy. American family physician, 2015, Sep-15, Volume: 92, Issue:6 Topics: Acupuncture; Antiemetics; Female; Humans; Hydrocortisone; Hyperemesis Gravidarum; Metoclopramide; Mo	2015
Motherisk and Canadian Family Physician. Canadian family physician Medecin de famille canadien, 2017, Volume: 63, Issue:1 Topics: Canada; Doxylamine; Female; Guideline Adherence; Humans; Hyperemesis Gravidarum; Physicians, Family;	2017
The management of nausea and vomiting of pregnancy. Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 2002, Volume: 24, Issue:10 Topics: Algorithms; Anti-Inflammatory Agents; Antiemetics; Complementary Therapies; Cost of Illness; Decisio	2002
[Treatment of hyperemesis gravidarum with combined inositol and pyridoxine]. Gazzetta medica italiana, 1955, Volume: 114, Issue:10 Topics: Female; Humans; Hyperemesis Gravidarum; Inositol; Pregnancy; Pregnancy Complications; Pyridoxine; Vi	1955
Evaluation of a combination of meclizine and pyridoxine in the control of nausea and vomiting in pregnancy. International record of medicine, 1960, Volume: 173 Topics: Anti-Allergic Agents; Female; Histamine H1 Antagonists; Humans; Hyperemesis Gravidarum; Meclizine; N	1960
Clinical experience with a combination of trimethobenzamide and pyridoxine in patients with nausea and vomiting of pregnancy. The Journal of the Tennessee State Medical Association. Tennessee State Medical Association, 1960, Volume: 53 Topics: Antiemetics; Benzamides; Female; Humans; Hyperemesis Gravidarum; Nausea; Pregnancy; Pregnancy Compli	1960
Nausea and vomiting in pregnancy. A trial of meclozine dihydrochloride with and without pyridoxine. Lancet (London, England), 1962, Aug-25, Volume: 2, Issue:7252 Topics: Antiemetics; Female; Humans; Hyperemesis Gravidarum; Meclizine; Nausea; Pregnancy; Pyridoxine; Vomit	1962
[USE OF CHLOROPHENOTHIAZINYLSCOPINE IN HYPEREMESIS GRAVIDARUM]. Anais paulistas de medicina e cirurgia, 1963, Volume: 85 Topics: Antipsychotic Agents; Female; Humans; Hyperemesis Gravidarum; Phenothiazines; Pregnancy; Procaine; P	1963
HYPEREMESIS GRAVIDARUM. The Practitioner, 1964, Volume: 192 Topics: Blood Chemical Analysis; Female; Humans; Hyperemesis Gravidarum; Meclizine; Nausea; Pathology; Pregn	1964
A DOUBLE BLIND STUDY OF FLUPHENAZINE WITH PYRIDOXINE. Pennsylvania medical journal (1928), 1964, Volume: 67 Topics: Biometry; Double-Blind Method; Female; Fluphenazine; Humans; Hyperemesis Gravidarum; Placebos; Pregn	1964
[APROPOS OF THE TREATMENT OF HYPEREMESIS GRAVIDARUM]. Akusherstvo i ginekologiia, 1964, Volume: 3 Topics: Female; Humans; Hyperemesis Gravidarum; Meclizine; Pregnancy; Pyridoxine	1964
[FAINTING AND NAUSEA OF PREGNANCY. ITS THERAPY WITH A COMBINATION OF A NEW POORLY SOLUBLE SALT OF DIPHENHYDRAMINE, SCOPOLAMINE AND PYRIDOXINE]. Prensa medica argentina, 1963, Dec-06, Volume: 50 Topics: Diphenhydramine; Female; Humans; Hyperemesis Gravidarum; Nausea; Pharmacology; Pregnancy; Pyridoxine	1963
[ASSOCIATION OF VITAMINS B 1 AND B 6 IN HIGH DOSES IN THERAPY OF HYPEREMESIS GRAVIDARUM]. Annali di ostetricia e ginecologia, 1965, Volume: 87 Topics: Female; Humans; Hyperemesis Gravidarum; Pregnancy; Pyridoxine; Thiamine; Vitamins	1965
[Adrenal cortex hormones and pyridoxine in therapy of hyperemesis gravidarum]. Rivista d'ostetricia e ginecologia pratica, 1955, Volume: 37, Issue:3 Topics: Adrenal Cortex; Adrenal Cortex Hormones; Female; Hyperemesis Gravidarum; Pregnancy; Pregnancy Compli	1955
Nausea of pregnancy: a "natural" remedy. Postgraduate medicine, 1983, Volume: 74, Issue:5 Topics: Female; Humans; Hyperemesis Gravidarum; Pregnancy; Pyridoxine	1983
Birth defects in relation to Bendectin use in pregnancy. II. Pyloric stenosis. American journal of obstetrics and gynecology, 1983, Dec-01, Volume: 147, Issue:7 Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Hyperemesis	1983
Therapeutic drugs in pregnancy. Caution is the watchword. Postgraduate medicine, 1984, Volume: 75, Issue:8 Topics: Abnormalities, Drug-Induced; Analgesics; Anti-Bacterial Agents; Anti-Infective Agents; Anticonvulsan	1984
Drug therapies for hyperemesis gravidarum. Canadian family physician Medecin de famille canadien, 1997, Volume: 43 Topics: Administration, Oral; Antiemetics; Doxylamine; Female; Humans; Hyperemesis Gravidarum; Infusions, In	1997
Selections from current literature. Complementary therapies for nausea and vomiting in early pregnancy. Family practice, 2000, Volume: 17, Issue:6 Topics: Complementary Therapies; Female; Humans; Hyperemesis Gravidarum; Nausea; Phytotherapy; Plants, Medic	2000
CDC study: no evidence for teratogenicity of Bendectin. JAMA, 1979, Dec-07, Volume: 242, Issue:23 Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Heart	1979
[Vitamin b6 depletion in women with hyperemesis gravidarum (author's transl)]. Wiener klinische Wochenschrift, 1975, Sep-05, Volume: 87, Issue:16 Topics: Female; Humans; Hyperemesis Gravidarum; Pregnancy; Pregnancy Trimester, Third; Pyridoxine; Vitamin B	1975
Drugs in pregnancy. Australian College of Midwives Incorporated journal, 1990, Volume: 2, Issue:4 Topics: Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Hyperemesis Gravidarum; Pregnancy; Pyrid	1990
Congenital heart disease in relation to maternal use of Bendectin and other drugs in early pregnancy. The New England journal of medicine, 1985, Aug-08, Volume: 313, Issue:6 Topics: Acetaminophen; Adult; Anti-Bacterial Agents; Antiemetics; Aspirin; Dicyclomine; Doxylamine; Drug Com	1985
[Metoclopramide and hyperemesis gravidarum: a comparative evaluation in four cases]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1968, Mar-20, Volume: 44, Issue:14 Topics: Adolescent; Adult; Antiemetics; Female; Humans; Hyperemesis Gravidarum; Parasympatholytics; Pregnanc	1968
Vitamin B6 nutrition in women with hyperemesis gravidarum during the first trimester of pregnancy. Clinica chimica acta; international journal of clinical chemistry, 1974, Aug-30, Volume: 55, Issue:1 Topics: Female; Humans; Hyperemesis Gravidarum; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester,	1974
[Hyperemesis in the first trimester of pregnancy: causes and therapeutic advances]. Ospedali d'Italia - chirurgia, 1967, Volume: 17, Issue:6 Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Adult; Chlorpromazine; Female; Humans; Hyperem	1967
[On the treatment of hyperemesis gravidarum. Clinical case studies]. Minerva ginecologica, 1967, Apr-30, Volume: 19, Issue:8 Topics: Adult; Female; Humans; Hyperemesis Gravidarum; Pregnancy; Pregnancy Complications; Pyridoxine; Thiam	1967
[Pyridoxine in the treatment of early pregnancy toxemias. II. Theoretical contribution to the mechanism of action of vitamin B 6]. Zeitschrift fur Geburtshilfe und Gynakologie, 1969, Volume: 170, Issue:2 Topics: Adult; Female; Gastric Juice; Gestational Age; Humans; Hyperemesis Gravidarum; Hypothalamo-Hypophyse	1969
[Pyridoxine in the treatment of early pregnancy toxemia. I. Change of gastric secretion under the effect of vitamin B 6 controlled by Acidotest]. Zeitschrift fur Geburtshilfe und Gynakologie, 1969, Volume: 170, Issue:1 Topics: Adult; Female; Gastric Acidity Determination; Gastric Juice; Humans; Hyperemesis Gravidarum; Pregnan	1969
[Hyperemesis gravidarum as an obstetrical problem. Its treatment with fluphenazine and pyridoxine]. Medicina, 1965, Oct-10, Volume: 45, Issue:973 Topics: Adult; Female; Fluphenazine; Humans; Hyperemesis Gravidarum; Pregnancy; Pyridoxine	1965