pyridoxine has been researched along with HbS Disease in 11 studies
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The role of zinc in sickle cell disease has received considerable attention." | 2.37 | Nutrition and sickle cell disease. ( Orringer, EP; Redding-Lallinger, R; Reed, JD, 1987) |
| "In 16 patients with sickle cell anemia, plasma pyridoxal phosphate (PLP) concentrations were significantly lower than in 16 controls (p less than 0." | 1.27 | Apparent vitamin B6 deficiency in sickle cell anemia. ( Natta, CL; Reynolds, RD, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (81.82) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Ugwu, NI | 1 |
| Manafa, PO | 1 |
| Agina, SE | 1 |
| Onah, CE | 1 |
| Okocha, EC | 1 |
| Natta, CL | 1 |
| Reynolds, RD | 1 |
| Solomon, LR | 1 |
| Kuranstin-Mills, J | 1 |
| Lessin, LS | 2 |
| van der Dijs, FP | 1 |
| Schnog, JJ | 1 |
| Brouwer, DA | 1 |
| Velvis, HJ | 1 |
| van den Berg, GA | 1 |
| Bakker, AJ | 1 |
| Duits, AJ | 1 |
| Muskiet, FD | 1 |
| Muskiet, FA | 1 |
| Nalbandian, RM | 1 |
| Henry, RL | 1 |
| Murayama, M | 1 |
| Kark, JA | 1 |
| Kale, MP | 1 |
| Tarassoff, PG | 1 |
| Woods, M | 1 |
| Flores, L | 1 |
| Pais, R | 1 |
| Buchanan, I | 1 |
| Arnelle, D | 1 |
| Camp, VM | 1 |
| Kutner, M | 1 |
| Faraj, BA | 1 |
| Eckman, J | 1 |
| Ragab, A | 1 |
| Reed, JD | 1 |
| Redding-Lallinger, R | 1 |
| Orringer, EP | 1 |
| Adelekan, DA | 1 |
| Adekile, AD | 1 |
| Thurnham, DI | 1 |
| Beutler, E | 1 |
| Paniker, NV | 1 |
| West, CJ | 1 |
1 review available for pyridoxine and HbS Disease
| Article | Year |
|---|---|
Nutrition and sickle cell disease.
Topics: Anemia, Sickle Cell; Avitaminosis; Folic Acid; Food; Humans; Minerals; Nutritional Status; Pyridoxin | 1987 |
1 trial available for pyridoxine and HbS Disease
| Article | Year |
|---|---|
Elevated homocysteine levels indicate suboptimal folate status in pediatric sickle cell patients.
Topics: Adolescent; Anemia, Sickle Cell; Child; Child, Preschool; Dietary Supplements; Female; Folic Acid; H | 1998 |
9 other studies available for pyridoxine and HbS Disease
| Article | Year |
|---|---|
Evaluation of Homocysteine Status and its Correlation with Disease Severity in Individuals with Sickle Cell Anaemia in Steady State.
Topics: Adult; Anemia, Sickle Cell; Cross-Sectional Studies; Humans; Patient Acuity; Pyridoxine; Sickle Cell | 2023 |
Apparent vitamin B6 deficiency in sickle cell anemia.
Topics: Anemia, Sickle Cell; Erythrocytes; Female; Hematocrit; Hemoglobins; Humans; Male; Plasma; Pyridoxine | 1984 |
Considerations in the use of B6 vitamers in hematologic disorders: I. Red cell transport and metabolism of pyridoxal.
Topics: Anemia, Sickle Cell; Apoenzymes; Aspartate Aminotransferases; Biological Transport; Blood Proteins; | 1982 |
Rheological assessment of antisickling effects of pyridoxine and pyridoxal.
Topics: Anemia, Sickle Cell; Antisickling Agents; Blood Flow Velocity; Erythrocytes, Abnormal; Humans; Oxyge | 1982 |
Sickle-cell disease: Two new therapeutic strategies.
Topics: Anemia, Sickle Cell; Antisickling Agents; Drug Evaluation; Erythrocyte Membrane; Humans; Molecular C | 1978 |
Inhibition of erythrocyte sickling in vitro by pyridoxal.
Topics: Anemia, Sickle Cell; Erythrocytes, Abnormal; Glyceraldehyde; Hemoglobin, Sickle; Humans; Macromolecu | 1978 |
Pyridoxal 5'-phosphate levels in children with sickle cell disease.
Topics: Adolescent; Anemia, Sickle Cell; Black People; Child; Child, Preschool; Hemoglobins; Humans; Infant; | 1988 |
Dependence of pyridoxine metabolism on riboflavin status in sickle cell patients.
Topics: Adolescent; Anemia, Sickle Cell; Aspartate Aminotransferases; Child; Child, Preschool; Erythrocytes; | 1987 |
Pyridoxine administration in sickle cell disease: an unsuccessful attempt to influence the properties of sickle hemoglobin.
Topics: Anemia, Sickle Cell; Aspartate Aminotransferases; Blood Viscosity; Chromium Isotopes; Erythrocytes; | 1972 |