pyridoxine has been researched along with Gyrate Atrophy in 9 studies
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
Gyrate Atrophy: Progressive, autosomal recessive, diffuse atrophy of the choroid, pigment epithelium, and sensory retina that begins in childhood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Case report of an adult patient with advanced gyrate atrophy, who underwent treatment with pyridoxine and an arginine-restricted diet for four years." | 8.31 | A possible ocular biomarker for response to hyperornithinemia in gyrate atrophy: the effect of pyridoxine, lysine, and arginine-restricted diet in a patient with advanced disease. ( Burr, A; da Palma, MM; Igelman, AD; Koerner, C; Ku, C; Pennesi, ME; Shevchenko Sutherland, L; Valle, D; Yang, P, 2023) |
| "Two clinical subtypes of gyrate atrophy (GA) have been defined based on in vivo or in vitro evidence of response to vitamin B6 (pyridoxine), which is the cofactor of the enzyme ornithine aminotransferase (OAT) shown to be defective in GA." | 7.70 | Genotype-phenotype correlation of a pyridoxine-responsive form of gyrate atrophy. ( Inana, G; Kennaway, NG; Mashima, YG; Weleber, RG, 1999) |
| "Gyrate atrophy is a rare autosomal recessive disorder caused by a mutation in the ornithine-δ-amino transferase gene." | 3.88 | Unique case of gyrate atrophy with a well-preserved electroretinogram (ERG). ( Black, G; Jasani, KM; Kelly, SP; Parry, NRA, 2018) |
| "Two clinical subtypes of gyrate atrophy (GA) have been defined based on in vivo or in vitro evidence of response to vitamin B6 (pyridoxine), which is the cofactor of the enzyme ornithine aminotransferase (OAT) shown to be defective in GA." | 3.70 | Genotype-phenotype correlation of a pyridoxine-responsive form of gyrate atrophy. ( Inana, G; Kennaway, NG; Mashima, YG; Weleber, RG, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| da Palma, MM | 1 |
| Ku, C | 1 |
| Igelman, AD | 1 |
| Burr, A | 1 |
| Shevchenko Sutherland, L | 1 |
| Koerner, C | 1 |
| Valle, D | 2 |
| Pennesi, ME | 1 |
| Yang, P | 1 |
| Heller, D | 1 |
| Weiner, C | 1 |
| Nasie, I | 1 |
| Anikster, Y | 1 |
| Landau, Y | 1 |
| Koren, T | 1 |
| Pokroy, R | 1 |
| Abulafia, A | 1 |
| Pras, E | 1 |
| Jasani, KM | 1 |
| Parry, NRA | 1 |
| Black, G | 1 |
| Kelly, SP | 1 |
| Montioli, R | 1 |
| Desbats, MA | 1 |
| Grottelli, S | 1 |
| Doimo, M | 1 |
| Bellezza, I | 1 |
| Borri Voltattorni, C | 1 |
| Salviati, L | 1 |
| Cellini, B | 1 |
| Tanzer, F | 1 |
| Firat, M | 1 |
| Alagoz, M | 1 |
| Erdogan, H | 1 |
| Fleury, M | 1 |
| Barbier, R | 1 |
| Ziegler, F | 1 |
| Mohr, M | 1 |
| Caron, O | 1 |
| Dollfus, H | 1 |
| Tranchant, C | 1 |
| Warter, JM | 1 |
| Michaud, J | 1 |
| Thompson, GN | 1 |
| Brody, LC | 1 |
| Steel, G | 1 |
| Obie, C | 1 |
| Fontaine, G | 1 |
| Schappert, K | 1 |
| Keith, CG | 1 |
| Mitchell, GA | 1 |
| Mashima, YG | 1 |
| Weleber, RG | 2 |
| Kennaway, NG | 1 |
| Inana, G | 1 |
| Wilson, DJ | 1 |
| Green, WR | 1 |
1 trial available for pyridoxine and Gyrate Atrophy
| Article | Year |
|---|---|
Pyridoxine-responsive gyrate atrophy of the choroid and retina: clinical and biochemical correlates of the mutation A226V.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cells, Cultured; Child; CHO Cells; Cricetinae; Cricetul | 1995 |
8 other studies available for pyridoxine and Gyrate Atrophy
| Article | Year |
|---|---|
A possible ocular biomarker for response to hyperornithinemia in gyrate atrophy: the effect of pyridoxine, lysine, and arginine-restricted diet in a patient with advanced disease.
Topics: Arginine; Biomarkers; Diet; Female; Gyrate Atrophy; Humans; Lysine; Middle Aged; Ornithine; Pyridoxi | 2023 |
Reversal of cystoid macular edema in gyrate atrophy patients.
Topics: Administration, Oral; Adolescent; Adult; Combined Modality Therapy; Consanguinity; Diet, Protein-Res | 2017 |
Unique case of gyrate atrophy with a well-preserved electroretinogram (ERG).
Topics: Adult; Cataract; Cataract Extraction; Diet, Protein-Restricted; Disease Progression; Electroretinogr | 2018 |
Molecular and cellular basis of ornithine δ-aminotransferase deficiency caused by the V332M mutation associated with gyrate atrophy of the choroid and retina.
Topics: Coenzymes; CRISPR-Cas Systems; Enzyme Assays; Gene Knockout Techniques; Gyrate Atrophy; HEK293 Cells | 2018 |
Gyrate atrophy of the choroid and retina with hyperornithinemia, cystinuria and lysinuria responsive to vitamin B6.
Topics: Biomarkers; Child; Cystinuria; Female; Gyrate Atrophy; Humans; Lysine; Night Blindness; Ornithine; P | 2011 |
Myopathy with tubular aggregates and gyrate atrophy of the choroid and retina due to hyperornithinaemia.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Arginine; Diet, Protein-Restricted; Gyrate Atrophy; Hum | 2007 |
Genotype-phenotype correlation of a pyridoxine-responsive form of gyrate atrophy.
Topics: Amino Acid Sequence; Amino Acid Substitution; Base Sequence; DNA; DNA Mutational Analysis; Family He | 1999 |
Ocular clinicopathologic study of gyrate atrophy.
Topics: Aged; Aged, 80 and over; Endothelium, Corneal; Female; Fluorescein Angiography; Fundus Oculi; Gyrate | 1991 |