pyridoxine has been researched along with Genetic Predisposition in 15 studies
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hand-foot syndrome (HFS) is a common adverse effect of capecitabine treatment." | 9.24 | Predictors of Hand-Foot Syndrome and Pyridoxine for Prevention of Capecitabine-Induced Hand-Foot Syndrome: A Randomized Clinical Trial. ( Chay, WY; Chia, JWK; Choo, SP; Dent, RA; Koh, KX; Koo, WH; Kwok, LL; Lo, SK; Loh, M; Mok, ZY; Ng, RCH; Soong, RCT; Syn, N; Tan, S; Tham, CK; Toh, HC; Wong, NS; Yap, YS, 2017) |
| "Homocystinuria (HCU) due to cystathionine beta-synthase (CBS) deficiency leads to severe hyperhomocysteinemia (HHcy)." | 8.80 | Vascular complications of severe hyperhomocysteinemia in patients with homocystinuria due to cystathionine beta-synthase deficiency: effects of homocysteine-lowering therapy. ( Boers, GH; Naughten, ER; Wilcken, B; Wilcken, DE; Yap, S, 2000) |
| "Pyridoxine-dependent epilepsy (PDE) is a rare autosomal recessive disorder characterized by intractable seizures in neonates and infants." | 7.81 | First cases of pyridoxine-dependent epilepsy in Bulgaria: novel mutation in the ALDH7A1 gene. ( Bojidarova, M; Georgieva, B; Georgieva, R; Kadiyska, T; Litvinenko, I; Mitev, V; Stamatov, D; Tacheva, G; Tincheva, S; Todorov, T; Todorova, A; Yordanova, I, 2015) |
| "Pyridoxine-dependent epilepsy is a disorder associated with severe seizures that may be caused by deficient activity of α-aminoadipic semialdehyde dehydrogenase, encoded by the ALDH7A1 gene, with accumulation of α-aminoadipic semialdehyde and piperideine-6-carboxylic acid." | 7.76 | The genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy due to mutations in ALDH7A1. ( Brocker, C; Creadon-Swindell, G; Gallagher, RC; Scharer, G; Spector, E; Van Hove, JL; Vasiliou, V, 2010) |
| "Hyperhomocysteinemia has been identified as a potential risk factor for atherosclerosis." | 7.70 | Hyperhomocysteinemia but not the C677T mutation of methylenetetrahydrofolate reductase is an independent risk determinant of carotid wall thickening. The Perth Carotid Ultrasound Disease Assessment Study (CUDAS) ( Beilby, JP; Hung, J; McQuillan, BM; Nidorf, M; Thompson, PL, 1999) |
| "Hand-foot syndrome (HFS) is a common adverse effect of capecitabine treatment." | 5.24 | Predictors of Hand-Foot Syndrome and Pyridoxine for Prevention of Capecitabine-Induced Hand-Foot Syndrome: A Randomized Clinical Trial. ( Chay, WY; Chia, JWK; Choo, SP; Dent, RA; Koh, KX; Koo, WH; Kwok, LL; Lo, SK; Loh, M; Mok, ZY; Ng, RCH; Soong, RCT; Syn, N; Tan, S; Tham, CK; Toh, HC; Wong, NS; Yap, YS, 2017) |
| "Homocystinuria (HCU) due to cystathionine beta-synthase (CBS) deficiency leads to severe hyperhomocysteinemia (HHcy)." | 4.80 | Vascular complications of severe hyperhomocysteinemia in patients with homocystinuria due to cystathionine beta-synthase deficiency: effects of homocysteine-lowering therapy. ( Boers, GH; Naughten, ER; Wilcken, B; Wilcken, DE; Yap, S, 2000) |
| "Pyridoxine-dependent epilepsy (PDE) is a rare autosomal recessive disorder characterized by intractable seizures in neonates and infants." | 3.81 | First cases of pyridoxine-dependent epilepsy in Bulgaria: novel mutation in the ALDH7A1 gene. ( Bojidarova, M; Georgieva, B; Georgieva, R; Kadiyska, T; Litvinenko, I; Mitev, V; Stamatov, D; Tacheva, G; Tincheva, S; Todorov, T; Todorova, A; Yordanova, I, 2015) |
| "Pyridoxine-dependent epilepsy is a disorder associated with severe seizures that may be caused by deficient activity of α-aminoadipic semialdehyde dehydrogenase, encoded by the ALDH7A1 gene, with accumulation of α-aminoadipic semialdehyde and piperideine-6-carboxylic acid." | 3.76 | The genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy due to mutations in ALDH7A1. ( Brocker, C; Creadon-Swindell, G; Gallagher, RC; Scharer, G; Spector, E; Van Hove, JL; Vasiliou, V, 2010) |
| "Hyperhomocysteinemia has been identified as a potential risk factor for atherosclerosis." | 3.70 | Hyperhomocysteinemia but not the C677T mutation of methylenetetrahydrofolate reductase is an independent risk determinant of carotid wall thickening. The Perth Carotid Ultrasound Disease Assessment Study (CUDAS) ( Beilby, JP; Hung, J; McQuillan, BM; Nidorf, M; Thompson, PL, 1999) |
| "The aim of this study was to investigate a possible association among the thermolabile polymorphism, nucleotide 677 cytosine to thymidine point mutation (677 C-->T) of the methylenetetrahydrofolate reductase (MTHFR) gene, hyperhomocysteinemia, serum folate, vitamins B12 and B6, and stroke in children." | 3.70 | Children with stroke: polymorphism of the MTHFR gene, mild hyperhomocysteinemia, and vitamin status. ( Artuch, R; Campistol, J; Cardo, E; Colomé, C; Monrós, E; Pineda, M; Vilaseca, MA, 2000) |
| "Early onset hypotonia, oculogyric crises, and autonomic symptoms such as excessive sweating, nasal congestion and profuse nasal, and oropharyngeal secretions, were common in our patients." | 1.56 | The genetic and clinical characteristics of aromatic L-amino acid decarboxylase deficiency in mainland China. ( Bao, X; Chen, Y; Wang, J; Wen, Y; Zhang, Q, 2020) |
| "Seizures are typically not responsive to conventional antiepileptic drugs, but they cease after parental pyridoxine administration." | 1.46 | Pyridoxine dependent epilepsies: new therapeutical point of view. ( Corsello, G; Falsaperla, R, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 8 (53.33) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Wen, Y | 1 |
| Wang, J | 1 |
| Zhang, Q | 1 |
| Chen, Y | 1 |
| Bao, X | 1 |
| Plecko, B | 1 |
| Zweier, M | 1 |
| Begemann, A | 1 |
| Mathis, D | 1 |
| Schmitt, B | 1 |
| Striano, P | 1 |
| Baethmann, M | 1 |
| Vari, MS | 1 |
| Beccaria, F | 1 |
| Zara, F | 1 |
| Crowther, LM | 1 |
| Joset, P | 1 |
| Sticht, H | 1 |
| Papuc, SM | 1 |
| Rauch, A | 1 |
| Yap, YS | 1 |
| Kwok, LL | 1 |
| Syn, N | 1 |
| Chay, WY | 1 |
| Chia, JWK | 1 |
| Tham, CK | 1 |
| Wong, NS | 1 |
| Lo, SK | 1 |
| Dent, RA | 1 |
| Tan, S | 1 |
| Mok, ZY | 1 |
| Koh, KX | 1 |
| Toh, HC | 1 |
| Koo, WH | 1 |
| Loh, M | 1 |
| Ng, RCH | 1 |
| Choo, SP | 1 |
| Soong, RCT | 1 |
| Falsaperla, R | 1 |
| Corsello, G | 1 |
| Creasey, T | 1 |
| Biss, T | 1 |
| Lambert, J | 1 |
| Smith, F | 1 |
| Clark, B | 1 |
| Carey, P | 1 |
| Poloni, S | 1 |
| Sperb-Ludwig, F | 1 |
| Borsatto, T | 1 |
| Weber Hoss, G | 1 |
| Doriqui, MJR | 1 |
| Embiruçu, EK | 1 |
| Boa-Sorte, N | 1 |
| Marques, C | 1 |
| Kim, CA | 1 |
| Fischinger Moura de Souza, C | 1 |
| Rocha, H | 1 |
| Ribeiro, M | 1 |
| Steiner, CE | 1 |
| Moreno, CA | 1 |
| Bernardi, P | 1 |
| Valadares, E | 1 |
| Artigalas, O | 1 |
| Carvalho, G | 1 |
| Wanderley, HYC | 1 |
| Kugele, J | 1 |
| Walter, M | 1 |
| Gallego-Villar, L | 1 |
| Blom, HJ | 1 |
| Schwartz, IVD | 1 |
| Sharawat, IK | 1 |
| Kasinathan, A | 1 |
| Sahu, JK | 1 |
| Sankhyan, N | 1 |
| Tincheva, S | 1 |
| Todorov, T | 1 |
| Todorova, A | 1 |
| Georgieva, R | 1 |
| Stamatov, D | 1 |
| Yordanova, I | 1 |
| Kadiyska, T | 1 |
| Georgieva, B | 1 |
| Bojidarova, M | 1 |
| Tacheva, G | 1 |
| Litvinenko, I | 1 |
| Mitev, V | 1 |
| Almeida, OP | 1 |
| McCaul, K | 1 |
| Hankey, GJ | 1 |
| Norman, P | 1 |
| Jamrozik, K | 1 |
| Flicker, L | 1 |
| Scharer, G | 1 |
| Brocker, C | 1 |
| Vasiliou, V | 1 |
| Creadon-Swindell, G | 1 |
| Gallagher, RC | 1 |
| Spector, E | 1 |
| Van Hove, JL | 1 |
| McQuillan, BM | 1 |
| Beilby, JP | 1 |
| Nidorf, M | 1 |
| Thompson, PL | 1 |
| Hung, J | 1 |
| de Jong, SC | 1 |
| Stehouwer, CD | 1 |
| van den Berg, M | 1 |
| Kostense, PJ | 1 |
| Alders, D | 1 |
| Jakobs, C | 1 |
| Pals, G | 1 |
| Rauwerda, JA | 1 |
| Cardo, E | 1 |
| Monrós, E | 1 |
| Colomé, C | 1 |
| Artuch, R | 1 |
| Campistol, J | 1 |
| Pineda, M | 1 |
| Vilaseca, MA | 1 |
| Boers, GH | 2 |
| Yap, S | 1 |
| Naughten, ER | 1 |
| Wilcken, B | 1 |
| Wilcken, DE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Double-Blind Placebo-Controlled Trial of Pyridoxine for Prevention of Capecitabine-Induced Hand-Foot Syndrome (HFS)[NCT00486213] | Phase 3 | 210 participants (Actual) | Interventional | 2007-06-30 | Terminated (stopped due to Slow accrual) | ||
| Effect of Topical Diclofenac on Clinical Outcome in Breast Cancer Patients Treated With Capecitabine: A Randomized Controlled Trial.[NCT05641246] | Phase 2 | 66 participants (Anticipated) | Interventional | 2022-12-08 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for pyridoxine and Genetic Predisposition
| Article | Year |
|---|---|
Homocysteine and depression in later life.
Topics: Age Factors; Aged; Cohort Studies; Depressive Disorder; Folic Acid; Genetic Predisposition to Diseas | 2008 |
Mild hyperhomocysteinemia is an independent risk factor of arterial vascular disease.
Topics: Arteriosclerosis; Case-Control Studies; Clinical Trials as Topic; Comorbidity; Coronary Disease; Fol | 2000 |
Vascular complications of severe hyperhomocysteinemia in patients with homocystinuria due to cystathionine beta-synthase deficiency: effects of homocysteine-lowering therapy.
Topics: Adolescent; Adult; Aged; Australia; Child; Child, Preschool; Cohort Studies; Cystine; Drug Resistanc | 2000 |
1 trial available for pyridoxine and Genetic Predisposition
| Article | Year |
|---|---|
Predictors of Hand-Foot Syndrome and Pyridoxine for Prevention of Capecitabine-Induced Hand-Foot Syndrome: A Randomized Clinical Trial.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Asian People; Capecitabine; Chi-Squ | 2017 |
Predictors of Hand-Foot Syndrome and Pyridoxine for Prevention of Capecitabine-Induced Hand-Foot Syndrome: A Randomized Clinical Trial.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Asian People; Capecitabine; Chi-Squ | 2017 |
Predictors of Hand-Foot Syndrome and Pyridoxine for Prevention of Capecitabine-Induced Hand-Foot Syndrome: A Randomized Clinical Trial.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Asian People; Capecitabine; Chi-Squ | 2017 |
Predictors of Hand-Foot Syndrome and Pyridoxine for Prevention of Capecitabine-Induced Hand-Foot Syndrome: A Randomized Clinical Trial.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Asian People; Capecitabine; Chi-Squ | 2017 |
11 other studies available for pyridoxine and Genetic Predisposition
| Article | Year |
|---|---|
The genetic and clinical characteristics of aromatic L-amino acid decarboxylase deficiency in mainland China.
Topics: Alleles; Amino Acid Metabolism, Inborn Errors; Aromatic-L-Amino-Acid Decarboxylases; China; Cohort S | 2020 |
Confirmation of mutations in
Topics: Adolescent; Adult; Alleles; Child; Child, Preschool; Consanguinity; DNA Mutational Analysis; Electro | 2017 |
Pyridoxine dependent epilepsies: new therapeutical point of view.
Topics: Anticonvulsants; Brain Diseases, Metabolic; Child, Preschool; Electroencephalography; Epilepsy; Fema | 2017 |
Pyridoxine-sensitive X-linked 'sideroblastic' anaemia in the absence of ring sideroblasts - molecular diagnosis.
Topics: 5-Aminolevulinate Synthetase; Alleles; Anemia, Sideroblastic; Child, Preschool; Erythrocytes; Genes, | 2018 |
CBS mutations are good predictors for B6-responsiveness: A study based on the analysis of 35 Brazilian Classical Homocystinuria patients.
Topics: Adolescent; Adult; Alleles; Base Sequence; Biomarkers, Pharmacological; Brazil; Child; Cystathionine | 2018 |
Response to Carbamazepine in KCNQ2 Related Early Infantile Epileptic Encephalopathy.
Topics: Carbamazepine; Electroencephalography; Exons; Genetic Predisposition to Disease; Humans; KCNQ2 Potas | 2019 |
First cases of pyridoxine-dependent epilepsy in Bulgaria: novel mutation in the ALDH7A1 gene.
Topics: Aldehyde Dehydrogenase; Anticonvulsants; Bulgaria; Child; Child, Preschool; Dietary Supplements; DNA | 2015 |
The genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy due to mutations in ALDH7A1.
Topics: Adolescent; Adult; Aldehyde Dehydrogenase; Anticonvulsants; Child; Child, Preschool; Colorado; Devel | 2010 |
Hyperhomocysteinemia but not the C677T mutation of methylenetetrahydrofolate reductase is an independent risk determinant of carotid wall thickening. The Perth Carotid Ultrasound Disease Assessment Study (CUDAS)
Topics: Adult; Aged; Amino Acid Substitution; Arteriosclerosis; Carotid Arteries; Carotid Stenosis; Comorbid | 1999 |
Determinants of fasting and post-methionine homocysteine levels in families predisposed to hyperhomocysteinemia and premature vascular disease.
Topics: Adult; Age Factors; Amino Acid Substitution; Arteriosclerosis; Body Mass Index; Comorbidity; Fasting | 1999 |
Children with stroke: polymorphism of the MTHFR gene, mild hyperhomocysteinemia, and vitamin status.
Topics: Adolescent; Case-Control Studies; Child; Child, Preschool; Cytosine; Female; Folic Acid; Genetic Pre | 2000 |