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pyridoxine and Friedreich Ataxia

pyridoxine has been researched along with Friedreich Ataxia in 2 studies

4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).

Friedreich Ataxia: An autosomal recessive disease, usually of childhood onset, characterized pathologically by degeneration of the spinocerebellar tracts, posterior columns, and to a lesser extent the corticospinal tracts. Clinical manifestations include GAIT ATAXIA, pes cavus, speech impairment, lateral curvature of spine, rhythmic head tremor, kyphoscoliosis, congestive heart failure (secondary to a cardiomyopathy), and lower extremity weakness. Most forms of this condition are associated with a mutation in a gene on chromosome 9, at band q13, which codes for the mitochondrial protein frataxin. (From Adams et al., Principles of Neurology, 6th ed, p1081; N Engl J Med 1996 Oct 17;335(16):1169-75) The severity of Friedreich ataxia associated with expansion of GAA repeats in the first intron of the frataxin gene correlates with the number of trinucleotide repeats. (From Durr et al, N Engl J Med 1996 Oct 17;335(16):1169-75)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19902 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rohmer, F1
Warter, JM1
Coquillat, G1
Maitrot, D1
Kurtz, D1
Micheletti, G1
Mack, G1
Mandel, P1
Hartmann-von Monakow, K1

Trials

1 trial available for pyridoxine and Friedreich Ataxia

ArticleYear
[Pharmacological and biochemical approach to a syndrome of action and intention myoclonus in the course of degenerative disease of the nervous system].
    Revue neurologique, 1973, Volume: 128, Issue:5

    Topics: 5-Hydroxytryptophan; Adult; Benzazepines; Cerebellar Ataxia; Clinical Trials as Topic; Diagnosis, Di

1973

Other Studies

1 other study available for pyridoxine and Friedreich Ataxia

ArticleYear
[Therapy of cerebellar diseases].
    Bibliotheca psychiatrica et neurologica, 1969, Volume: 139

    Topics: Ascorbic Acid; Atrophy; Barbiturates; Carbamates; Cerebellar Ataxia; Cerebellar Cortex; Cerebellar D

1969