pyridoxine has been researched along with Folic Acid Deficiency in 52 studies
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
Folic Acid Deficiency: A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pyridoxine, vitamin B6, is a cofactor for cystathionine beta synthase, which mediates the transformation of homocysteine to cystathionine, the initial step in the transsulfuration pathway and the urinary excretion of sulfur." | 6.40 | B vitamins and homocysteine in cardiovascular disease and aging. ( Wilcken, B; Wilcken, DE, 1998) |
| "Hyperhomocysteinemia refers to an elevated circulating level of the sulfur-containing amino acid homocysteine and has been shown to be a risk factor for vascular disease in the general population." | 4.80 | Homocysteine and renal disease. ( Robinson, K; van Guldener, C, 2000) |
| ", folate, cobalamin, or pyridoxine) potentiated by maternal dietary deficiency of these cofactors and by pregnancy." | 3.70 | DNA polymorphism-diet-cofactor-development hypothesis and the gene-teratogen model for schizophrenia and other developmental disorders. ( Johnson, WG, 1999) |
| "Pyridoxine, vitamin B6, is a cofactor for cystathionine beta synthase, which mediates the transformation of homocysteine to cystathionine, the initial step in the transsulfuration pathway and the urinary excretion of sulfur." | 2.40 | B vitamins and homocysteine in cardiovascular disease and aging. ( Wilcken, B; Wilcken, DE, 1998) |
| "Body weight was under 90% of the ideal in 8/33 (24%) patients." | 1.30 | Nutritional deficiencies in chronic alcoholics: relation to dietary intake and alcohol consumption. ( Camilo, ME; Cardoso, JN; Cravo, M; Glória, L; Leitão, CN; Mira, FC; Oliveira, AG; Resende, M, 1997) |
| "Clinical effects due to vitamin deficiency have been described for vitamin B6--namely, depression and impaired glucose tolerance." | 1.25 | Vitamins and oral contraceptive use. ( Wynn, V, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (63.46) | 18.7374 |
| 1990's | 11 (21.15) | 18.2507 |
| 2000's | 6 (11.54) | 29.6817 |
| 2010's | 2 (3.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Altun, H | 1 |
| Şahin, N | 1 |
| Belge Kurutaş, E | 1 |
| Güngör, O | 1 |
| Al-Baradie, RS | 1 |
| Chaudhary, MW | 1 |
| GROSS, S | 1 |
| Leevy, CM | 2 |
| Baker, H | 2 |
| Tenhove, W | 1 |
| Frank, O | 2 |
| Cherrick, GR | 1 |
| MACDONALD, RA | 1 |
| JONES, RS | 1 |
| PECHET, GS | 1 |
| AFONSKY, D | 1 |
| PORTER, PB | 1 |
| GRIFFIN, AC | 1 |
| STONE, CP | 1 |
| Pearl, PL | 1 |
| Capp, PK | 1 |
| Novotny, EJ | 1 |
| Gibson, KM | 1 |
| Lindhe, BA | 1 |
| Knox, DL | 1 |
| Chen, MF | 1 |
| Guilarte, TR | 1 |
| Dang, CV | 1 |
| Burnette, J | 1 |
| Daghir, NJ | 1 |
| Haddad, KS | 1 |
| Hopkins, PN | 1 |
| Wu, LL | 1 |
| Wu, J | 1 |
| Hunt, SC | 1 |
| James, BC | 1 |
| Vincent, GM | 1 |
| Williams, RR | 1 |
| Ubbink, JB | 1 |
| Vermaak, WJ | 1 |
| van der Merwe, A | 1 |
| Becker, PJ | 1 |
| Glória, L | 1 |
| Cravo, M | 1 |
| Camilo, ME | 1 |
| Resende, M | 1 |
| Cardoso, JN | 1 |
| Oliveira, AG | 1 |
| Leitão, CN | 1 |
| Mira, FC | 1 |
| Gupta, A | 1 |
| Moustapha, A | 1 |
| Jacobsen, DW | 1 |
| Goormastic, M | 1 |
| Tuzcu, EM | 1 |
| Hobbs, R | 1 |
| Young, J | 1 |
| James, K | 1 |
| McCarthy, P | 1 |
| van Lente, F | 1 |
| Green, R | 1 |
| Robinson, K | 2 |
| Tamura, T | 1 |
| Bergman, SM | 1 |
| Morgan, SL | 1 |
| Wilcken, DE | 1 |
| Wilcken, B | 1 |
| Schwaninger, M | 1 |
| Ringleb, P | 1 |
| Winter, R | 1 |
| Kohl, B | 1 |
| Fiehn, W | 1 |
| Rieser, PA | 1 |
| Walter-Sack, I | 1 |
| Lubbers, MF | 1 |
| Aarnoudse, JG | 1 |
| van Doormaal, JJ | 1 |
| Johnson, WG | 1 |
| Essama-Tjani, JC | 1 |
| Guilland, JC | 1 |
| Potier de Courcy, G | 1 |
| Fuchs, F | 1 |
| Richard, D | 1 |
| van Guldener, C | 1 |
| Herrmann, W | 1 |
| Schorr, H | 1 |
| Bodis, M | 1 |
| Knapp, JP | 1 |
| Müller, A | 1 |
| Stein, G | 1 |
| Geisel, J | 1 |
| McKinley, MC | 1 |
| McNulty, H | 1 |
| McPartlin, J | 1 |
| Strain, JJ | 1 |
| Pentieva, K | 1 |
| Ward, M | 1 |
| Weir, DG | 1 |
| Scott, JM | 1 |
| Kutschka, I | 1 |
| Pethig, K | 1 |
| Strüber, M | 1 |
| Dieterich, C | 1 |
| Harringer, W | 1 |
| Haverich, A | 1 |
| Wynn, V | 1 |
| Grühn, E | 1 |
| Elmadfa, I | 1 |
| Zetterman, RK | 1 |
| Rajan, KS | 1 |
| ten Hove, W | 1 |
| Larsson-Cohn, U | 1 |
| Clements, FW | 1 |
| Mason, JB | 1 |
| Miller, JW | 1 |
| Bell, IR | 1 |
| Morrow, FD | 1 |
| Read, M | 1 |
| Berkes, S | 1 |
| Perrone, G | 1 |
| Boeschoten, EW | 1 |
| Schrijver, J | 1 |
| Krediet, RT | 1 |
| Schreurs, WH | 1 |
| Arisz, L | 1 |
| Blair, R | 1 |
| Newsome, F | 1 |
| Truswell, AS | 1 |
| Reynolds, EH | 1 |
| Mollin, DL | 1 |
| MacGibbon, BH | 1 |
| Sullivan, AL | 1 |
| Weintraub, LR | 2 |
| Cowan, DH | 2 |
| Hines, JD | 2 |
| Waxman, S | 1 |
| Corcino, J | 1 |
| Herbert, V | 1 |
| Bamji, MS | 1 |
| Morrow, G | 1 |
| Barness, LA | 1 |
| Zinsser, HH | 1 |
| Stern, F | 1 |
| Marshall, S | 1 |
| Karp, F | 1 |
| Seneca, E | 1 |
| Gursel, E | 1 |
| Axelrod, AE | 1 |
| Mayer, J | 1 |
| Carson, NA | 1 |
| Carré, IJ | 1 |
| McCurdy, PR | 1 |
| Donohoe, RF | 1 |
| Magovern, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effects of Glycine Transport Inhibition on Brain Glycine Concentration[NCT00538070] | 68 participants (Actual) | Interventional | 2007-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 reviews available for pyridoxine and Folic Acid Deficiency
| Article | Year |
|---|---|
Inherited disorders of neurotransmitters in children and adults.
Topics: Adult; Biopterins; Brain Diseases, Metabolic, Inborn; Child; Folic Acid Deficiency; Humans; Infant, | 2005 |
Nutritional amblyopia. Folic acid, vitamin B-12, and other vitamins.
Topics: Amblyopia; Erythrocytes; Folic Acid; Folic Acid Deficiency; Humans; Niacin; Nutrition Disorders; Pyr | 1982 |
Hyperhomocysteinemia as a cause of vascular occlusion in end-stage-renal disease.
Topics: Cardiovascular Diseases; Dietary Supplements; Folic Acid; Folic Acid Deficiency; Hematinics; Homocys | 1998 |
B vitamins and homocysteine in cardiovascular disease and aging.
Topics: Aging; Cardiovascular Diseases; Diet; Folic Acid; Folic Acid Deficiency; Homocysteine; Homocystinuri | 1998 |
Homocysteine and renal disease.
Topics: Adult; Arteriosclerosis; Cardiovascular Diseases; Case-Control Studies; Child; Endothelium, Vascular | 2000 |
Oral contraceptives and vitamins: a review.
Topics: Ascorbic Acid; Contraceptives, Oral; Depression; Estradiol Congeners; Female; Folic Acid; Folic Acid | 1975 |
The effects of vitamins B12, B6, and folate on blood homocysteine levels.
Topics: Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Pyridoxine; Vitamin B 12; Vitamin B 12 Defi | 1992 |
Involvement of water-soluble vitamins in diseases of swine.
Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Biotin; Choline; Choline Deficiency; Folic Acid; F | 1985 |
Sideroblastic and megaloblastic anaemias.
Topics: Anemia, Macrocytic; Anemia, Sideroblastic; Animals; Biological Assay; Erythrocyte Count; Erythrocyte | 1972 |
Sideroblastic anemias. An approach to diagnosis and management.
Topics: Alcoholism; Anemia, Sideroblastic; Erythrocytes, Abnormal; Female; Folic Acid Deficiency; Genes; Hem | 1973 |
Aggravation or initiation of megaloblastosis by amino acids in the diet.
Topics: Amino Acids; Anemia, Pernicious; Cell Nucleus; Diet; DNA; Erythrocytes; Folic Acid; Folic Acid Defic | 1970 |
3 trials available for pyridoxine and Folic Acid Deficiency
| Article | Year |
|---|---|
Vitamin B-12, vitamin B-6, and folate nutritional status in men with hyperhomocysteinemia.
Topics: Adult; Aged; Cardiovascular Diseases; Cystathionine beta-Synthase; Dose-Response Relationship, Drug; | 1993 |
Low-dose vitamin B-6 effectively lowers fasting plasma homocysteine in healthy elderly persons who are folate and riboflavin replete.
Topics: Aged; Aged, 80 and over; Diet Records; Dietary Supplements; Double-Blind Method; Fasting; Female; Fo | 2001 |
Homocysteine--a treatable risk factor for allograft vascular disease after heart transplantation?
Topics: Aged; Cohort Studies; Cyclosporine; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; | 2001 |
38 other studies available for pyridoxine and Folic Acid Deficiency
| Article | Year |
|---|---|
Homocysteine, Pyridoxine, Folate and Vitamin B12 Levels in Children with Attention Deficit Hyperactivity Disorder.
Topics: Attention Deficit Disorder with Hyperactivity; Behavior Rating Scale; Child; Enzyme-Linked Immunosor | 2018 |
Diagnosis and management of cerebral folate deficiency. A form of folinic acid-responsive seizures.
Topics: Atrophy; Brain; Brain Diseases, Metabolic, Inborn; Child Development Disorders, Pervasive; Child, Pr | 2014 |
HEMATOLOGIC STUDIES ON ERYTHROPOIETIC PORPHYRIA: A NEW CASE WITH SEVERE HEMOLYSIS, CHRONIC THROMBOCYTOPENIA, AND FOLIC ACID DEFICIENCY.
Topics: Adenine Nucleotides; Anemia; Anemia, Hemolytic; Child; Drug Therapy; Erythropoiesis; Folic Acid; Fol | 1964 |
B-COMPLEX VITAMINS IN LIVER DISEASE OF THE ALCOHOLIC.
Topics: Alcoholism; Autoradiography; Biopsy; Biotin; Blood Chemical Analysis; DNA; Drug Therapy; Fatty Liver | 1965 |
FOLIC ACID DEFICIENCY AND HEMOCHROMATOSIS.
Topics: Blood Chemical Analysis; Choline; Diet; Folic Acid; Folic Acid Deficiency; Hematocrit; Hemochromatos | 1965 |
Oral lesions in niacin, riboflavin, pyridoxine, folic acid, and pantothenic acid deficiencies in adult dogs.
Topics: Folic Acid; Folic Acid Deficiency; Glossitis; Niacin; Pantothenic Acid; Pyridoxine; Riboflavin; Vita | 1955 |
Behavioral assessment of glutamic acid metabolism with observations on pyridoxine and folic acid deficiencies.
Topics: Folic Acid Deficiency; Glutamates; Humans; Learning; Pyridoxine | 1951 |
Pregnancy anemia with special reference to folic acid deficiency.
Topics: Anemia; Female; Folic Acid; Folic Acid Deficiency; Hemoglobinometry; Humans; Iron; Pregnancy; Pregna | 1967 |
Vitamin B6 in the etiology of gizzard erosion in growing chickens.
Topics: Animals; Chickens; Folic Acid Deficiency; Gizzard, Avian; Male; Poultry Diseases; Pyridoxine; Stomac | 1981 |
Higher plasma homocyst(e)ine and increased susceptibility to adverse effects of low folate in early familial coronary artery disease.
Topics: Adult; Aged; Coronary Disease; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Male | 1995 |
Nutritional deficiencies in chronic alcoholics: relation to dietary intake and alcohol consumption.
Topics: Adult; Alcohol Drinking; Alcoholism; Avitaminosis; Body Height; Body Mass Index; Body Weight; Diet; | 1997 |
High homocysteine, low folate, and low vitamin B6 concentrations: prevalent risk factors for vascular disease in heart transplant recipients.
Topics: Arteriosclerosis; Biomarkers; Coronary Thrombosis; Female; Folic Acid; Folic Acid Deficiency; Follow | 1998 |
Elevated plasma concentrations of homocysteine in antiepileptic drug treatment.
Topics: Age Factors; Ambulatory Care; Anticonvulsants; Carbamazepine; Convulsants; Depression, Chemical; Epi | 1999 |
[Obstetric problems followed by stroke].
Topics: Abortion, Habitual; Adult; Arteriosclerosis; Cerebral Infarction; Diagnosis, Differential; Female; F | 1999 |
DNA polymorphism-diet-cofactor-development hypothesis and the gene-teratogen model for schizophrenia and other developmental disorders.
Topics: Alleles; Brain; Diet; Female; Folic Acid; Folic Acid Deficiency; Genetic Linkage; Genotype; Humans; | 1999 |
Folate status worsens in recently institutionalized elderly people without evidence of functional deterioration.
Topics: Aged; Aged, 80 and over; Cognition; Diet Records; Female; Folic Acid; Folic Acid Deficiency; Follow- | 2000 |
Role of homocysteine, cystathionine and methylmalonic acid measurement for diagnosis of vitamin deficiency in high-aged subjects.
Topics: Adult; Aged; Cystathionine; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Kidney; | 2000 |
Vitamins and oral contraceptive use.
Topics: Anemia, Megaloblastic; Ascorbic Acid; Avitaminosis; Coenzymes; Contraceptives, Oral; Depression; Fem | 1975 |
[Nutrition physiology and pathology. Plant fibers in nutrition (proceedings)].
Topics: Aspartate Aminotransferases; Cachexia; Cholesterol; Constipation; Dietary Fiber; Energy Metabolism; | 1979 |
Inability of chronic alcoholics with liver disease to use food as a source of folates, thiamin and vitamin B6.
Topics: Adult; Female; Folic Acid; Folic Acid Deficiency; Humans; Intestinal Absorption; Liver Diseases, Alc | 1975 |
Nutrition 7. Vitamin and mineral supplementation.
Topics: Adult; Aged; Ascorbic Acid; Ascorbic Acid Deficiency; Burns; Child; Contraceptives, Oral; Depression | 1975 |
Low thyroxine levels in female psychiatric inpatients with riboflavin deficiency: implications for folate-dependent methylation.
Topics: Adult; Female; Folic Acid; Folic Acid Deficiency; Hospitalization; Humans; Male; Mental Disorders; M | 1992 |
Deficiencies of vitamins in CAPD patients: the effect of supplementation.
Topics: Adult; Ascorbic Acid; Ascorbic Acid Deficiency; Cross-Sectional Studies; Female; Folic Acid; Folic A | 1988 |
ABC of nutrition. Vitamins II.
Topics: Ascorbic Acid; Ascorbic Acid Deficiency; Avitaminosis; Folic Acid; Folic Acid Deficiency; Humans; Py | 1985 |
Iatrogenic nutritional effects of anticonvulsants.
Topics: Adolescent; Adult; Anticonvulsants; Blood Coagulation Disorders; Bone Diseases; Child; Child, Presch | 1974 |
Thrombokinetics in dietary-induced folate deficiency in human subjects.
Topics: Alcoholism; Blood Cell Count; Blood Platelets; Chromium Isotopes; Diet; Erythrocytes; Erythropoiesis | 1973 |
Editorial: Vitamins and the pill.
Topics: Anemia, Macrocytic; Ascorbic Acid; Ascorbic Acid Deficiency; Contraceptives, Oral; Depression; Femal | 1974 |
Erythrocyte glutathione reductase activity and riboflavin concentration in experimental deficiency of some water soluble vitamins.
Topics: Animal Nutritional Physiological Phenomena; Animals; Ascorbic Acid Deficiency; Avitaminosis; Body We | 1972 |
Combined vitamin responsiveness in homocystinuria.
Topics: Adolescent; Adult; Amino Acids; Child; Drug Synergism; Female; Folic Acid; Folic Acid Deficiency; Gl | 1972 |
Urinary organic acids found in B6-deficient rats and calcium oxalate calculus patients.
Topics: Acids; Amino Acids; Animals; Calcium; Chromatography, Paper; Citrates; Coenzyme A; Folic Acid Defici | 1971 |
Studies on the pathogenesis of alcohol-induced sideroblastic bone-marrow abnormalities.
Topics: Adult; Alcoholism; Anemia, Sideroblastic; Bone Marrow; Bone Marrow Examination; Erythrocytes; Ethano | 1970 |
The continuing saga of the sideroblast.
Topics: Alcoholism; Anemia, Sideroblastic; Bone Marrow; Ethanol; Folic Acid Deficiency; Heme; Humans; Iron; | 1970 |
Interaction of drugs and nutrients.
Topics: Amino Acids; Diet; Folic Acid; Folic Acid Deficiency; Food Analysis; Humans; Malaria; Pharmaceutical | 1970 |
Immune processes in vitamin deficiency states.
Topics: Antibody Formation; Antigen-Antibody Reactions; Avitaminosis; Erythrocytes; Folic Acid Deficiency; H | 1971 |
Iatrogenic malnutrition.
Topics: Adolescent; Anemia, Macrocytic; Anticonvulsants; Antitubercular Agents; Calcium; Celiac Disease; Chi | 1971 |
Depletion on dialysis.
Topics: Amino Acids; Deficiency Diseases; Folic Acid Deficiency; Humans; Peritoneal Dialysis; Pyridoxine; Re | 1969 |
Treatment of homocystinuria with pyridoxine. A preliminary study.
Topics: Adolescent; Adult; Aminobutyrates; Child; Child, Preschool; Cystine; Female; Folic Acid; Folic Acid | 1969 |
Reversible sideroblastic anemia caused by pyrazinoic acid (Pyrazinamide).
Topics: Adult; Aminosalicylic Acids; Anemia; Anemia, Sideroblastic; Erythropoiesis; Ethionamide; Female; Fol | 1966 |