Page last updated: 2024-10-20

pyridoxine and Epilepsy, Tonic-Clonic

pyridoxine has been researched along with Epilepsy, Tonic-Clonic in 13 studies

4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).

Epilepsy, Tonic-Clonic: A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)

Research Excerpts

ExcerptRelevanceReference
"A 14-yr old previously healthy girl receiving preventive isoniazid therapy who suddenly developed generalized tonic-clonic seizures and coma."3.70Acute isoniazid neurotoxicity during preventive therapy. ( Gorjup, V; Horvat, M; Martinjak-Dvorsek, I; Noc, M, 2000)
"A 11-year-old girl suffering from grand mal epilepsy underwent antiepileptic therapy with carbamazepine (600 mg/daily)."1.30[Dose-dependent pellagroid skin reaction caused by carbamazepine]. ( Heyer, G; Schell, H; Simon, M, 1998)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19906 (46.15)18.7374
1990's1 (7.69)18.2507
2000's5 (38.46)29.6817
2010's0 (0.00)24.3611
2020's1 (7.69)2.80

Authors

AuthorsStudies
Azuma, F1
Nokura, K1
Kako, T1
Kobayashi, D1
Yoshimura, T1
Wada, K1
Kalaci, A1
Duru, M1
Karazincir, S1
Sevinç, TT1
Kuvandik, G1
Balci, A1
Naasan, G1
Yabroudi, M1
Rahi, A1
Mikati, MA1
ARCANGELI, A1
DEVADATTA, S1
Thompson, MD1
Killoran, A1
Percy, ME1
Nezarati, M1
Cole, DE1
Hwang, PA1
Ozyurek, H1
Turker, H1
Akbalik, M1
Bayrak, AO1
Ince, H1
Duru, F1
Heyer, G1
Simon, M1
Schell, H1
Martinjak-Dvorsek, I1
Gorjup, V1
Horvat, M1
Noc, M1
Reinken, L1
Houillon, G1
Samulak, G1
Houillon, P1
Kochen, W2
Feist, D1

Other Studies

13 other studies available for pyridoxine and Epilepsy, Tonic-Clonic

ArticleYear
An Adult Case of Generalized Convulsions Caused by the Ingestion of Ginkgo biloba Seeds with Alcohol.
    Internal medicine (Tokyo, Japan), 2020, Jun-15, Volume: 59, Issue:12

    Topics: Alcoholic Beverages; Epilepsy, Tonic-Clonic; Female; Ginkgo biloba; Humans; Middle Aged; Pyridoxal P

2020
Thoracic spine compression fracture during isoniazid-induced seizures: case report.
    Pediatric emergency care, 2008, Volume: 24, Issue:12

    Topics: Antidotes; Back Pain; Charcoal; Child; Drug Overdose; Epilepsy, Tonic-Clonic; Female; Fractures, Com

2008
Electroencephalographic changes in pyridoxine-dependant epilepsy: new observations.
    Epileptic disorders : international epilepsy journal with videotape, 2009, Volume: 11, Issue:4

    Topics: Age of Onset; Electroencephalography; Epilepsies, Partial; Epilepsy, Generalized; Epilepsy, Tonic-Cl

2009
[EPILEPTIC SYNDROMES WITHIN THE FRAMEWORK OF CHRONIC HEADACHE].
    Rassegna di neurologia vegetativa, 1964, Feb-29, Volume: 18

    Topics: Anticonvulsants; Diencephalon; Endocrinology; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe;

1964
ISONIAZID-INDUCED ENCEPHALOPATHY.
    Lancet (London, England), 1965, Aug-28, Volume: 2, Issue:7409

    Topics: Brain Diseases; Drug Therapy; Epilepsy; Epilepsy, Tonic-Clonic; Isoniazid; Peripheral Nervous System

1965
Hyperphosphatasia with neurologic deficit: a pyridoxine-responsive seizure disorder?
    Pediatric neurology, 2006, Volume: 34, Issue:4

    Topics: Alkaline Phosphatase; Child, Preschool; Developmental Disabilities; Epilepsy, Tonic-Clonic; Female;

2006
Pyridoxine and pyridostigmine treatment in vincristine-induced neuropathy.
    Pediatric hematology and oncology, 2007, Volume: 24, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Axonal Transport; Blepharoptosis; Child, Preschool;

2007
[Dose-dependent pellagroid skin reaction caused by carbamazepine].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1998, Volume: 49, Issue:2

    Topics: Anticonvulsants; Biopsy; Carbamazepine; Child; Diagnosis, Differential; Drug Eruptions; Epilepsy, To

1998
Acute isoniazid neurotoxicity during preventive therapy.
    Critical care medicine, 2000, Volume: 28, Issue:2

    Topics: Acute Disease; Adolescent; Antitubercular Agents; Coma; Conscious Sedation; Electroencephalography;

2000
[The effect of hydantoin and succinimide on vitamin B 6 metabolism].
    Clinica chimica acta; international journal of clinical chemistry, 1973, Nov-15, Volume: 48, Issue:4

    Topics: Child; Child, Preschool; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Humans; Hydantoins; Infant; Pyri

1973
[Apropos of a case of Gayet-Wernicke's encephalopathy in a latent epileptic. Centrophenoxine and thiamine. Electro-clinical contraindications].
    Annales medico-psychologiques, 1968, Volume: 1, Issue:1

    Topics: Acetates; Adult; Central Nervous System Stimulants; Epilepsy, Tonic-Clonic; Humans; Hydroxocobalamin

1968
[Tryptophan metabolism in pyridoxine-dependent convulsions].
    Zeitschrift fur klinische Chemie und klinische Biochemie, 1971, Volume: 9, Issue:2

    Topics: Chemistry, Clinical; Child; Child, Preschool; Chromatography, Thin Layer; Epilepsy, Tonic-Clonic; Hu

1971
[Studies of tryptophan metabolism in pyridoxin-dependent convulsions].
    Monatsschrift fur Kinderheilkunde, 1971, Volume: 119, Issue:7

    Topics: Child, Preschool; Epilepsy, Tonic-Clonic; Humans; Metabolism, Inborn Errors; Pyridoxine; Tryptophan;

1971