pyridoxine has been researched along with Drug Overdose in 20 studies
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pyridoxine-dependent seizures have been recognised for 40 years, but the clinical and biochemical features are still not understood." | 8.82 | Pyridoxine-dependent seizures: a clinical and biochemical conundrum. ( Baxter, P, 2003) |
| "Isoniazid (INH) is an effective treatment for tuberculosis and among the most common causes of drug-induced seizures in the United States." | 5.36 | Isoniazid-induced status epilepticus in a pediatric patient after inadequate pyridoxine therapy. ( Clark, RF; Ghafouri, N; Minns, AB, 2010) |
| "Mexiletine is a group Ib antidysrhythmic agent with electrophysiologic effects similar to lidocaine." | 5.29 | Mexiletine overdose producing status epilepticus without cardiovascular abnormalities. ( Hoffman, RS; Nelson, LS, 1994) |
| "She was in respiratory failure, with seizures that could not be stopped with diazepam." | 5.29 | [Pyridoxine for severe metabolic acidosis and seizures due to isoniazid overdose]. ( Adler, M; Girsh-Solomonovich, Z; Raikhlin-Eisenkraft, B, 1993) |
| "Pyridoxine has been reported to be effective in treating isoniazid-induced seizures." | 5.28 | Reversal of prolonged isoniazid-induced coma by pyridoxine. ( Brent, J; Kulig, K; Rumack, BH; Vo, N, 1990) |
| "Pyridoxine-dependent seizures have been recognised for 40 years, but the clinical and biochemical features are still not understood." | 4.82 | Pyridoxine-dependent seizures: a clinical and biochemical conundrum. ( Baxter, P, 2003) |
| "A 25-year-old, 54-kg Hispanic man who had recently started multidrug therapy for pulmonary tuberculosis presented in status epilepticus after ingesting 9 g of isoniazid in a suicide attempt." | 3.73 | Acute isoniazid toxicity and the need for adequate pyridoxine supplies. ( Malesker, M; Morrow, LE; Schuller, D; Wear, RE, 2006) |
| "Isoniazid overdose is a potentially fatal intoxication." | 2.39 | Isoniazid overdose: four case reports and review of the literature. ( Alvarez, FG; Guntupalli, KK, 1995) |
| "Isoniazid has a low therapeutic margin and produces life threatening signs in dogs ingesting single 300 mg human tablets." | 2.39 | Treatment of acute isoniazid overdose in dogs. ( Barret, GH; Buck, WB; Holding, J; Knight, MK; Villar, D, 1995) |
| "Isoniazid (INH) is an effective treatment for tuberculosis and among the most common causes of drug-induced seizures in the United States." | 1.36 | Isoniazid-induced status epilepticus in a pediatric patient after inadequate pyridoxine therapy. ( Clark, RF; Ghafouri, N; Minns, AB, 2010) |
| "Mexiletine is a group Ib antidysrhythmic agent with electrophysiologic effects similar to lidocaine." | 1.29 | Mexiletine overdose producing status epilepticus without cardiovascular abnormalities. ( Hoffman, RS; Nelson, LS, 1994) |
| "She was in respiratory failure, with seizures that could not be stopped with diazepam." | 1.29 | [Pyridoxine for severe metabolic acidosis and seizures due to isoniazid overdose]. ( Adler, M; Girsh-Solomonovich, Z; Raikhlin-Eisenkraft, B, 1993) |
| "Pyridoxine has been reported to be effective in treating isoniazid-induced seizures." | 1.28 | Reversal of prolonged isoniazid-induced coma by pyridoxine. ( Brent, J; Kulig, K; Rumack, BH; Vo, N, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.00) | 18.7374 |
| 1990's | 13 (65.00) | 18.2507 |
| 2000's | 5 (25.00) | 29.6817 |
| 2010's | 1 (5.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kalaci, A | 1 |
| Duru, M | 1 |
| Karazincir, S | 1 |
| Sevinç, TT | 1 |
| Kuvandik, G | 1 |
| Balci, A | 1 |
| Minns, AB | 1 |
| Ghafouri, N | 1 |
| Clark, RF | 1 |
| Baxter, P | 1 |
| Caksen, H | 1 |
| Odabas, D | 1 |
| Erol, M | 1 |
| Anlar, O | 1 |
| Tuncer, O | 1 |
| Atas, B | 1 |
| STARKE, H | 1 |
| WILLIAMS, S | 1 |
| McLay, RN | 1 |
| Drake, A | 1 |
| Rayner, T | 1 |
| Morrow, LE | 1 |
| Wear, RE | 1 |
| Schuller, D | 1 |
| Malesker, M | 1 |
| Aggarwal, P | 1 |
| Nelson, LS | 2 |
| Hoffman, RS | 2 |
| Scharman, EJ | 1 |
| Rosencrane, JG | 1 |
| Adler, M | 1 |
| Girsh-Solomonovich, Z | 1 |
| Raikhlin-Eisenkraft, B | 1 |
| Alvarez, FG | 1 |
| Guntupalli, KK | 1 |
| Villar, D | 1 |
| Knight, MK | 1 |
| Holding, J | 1 |
| Barret, GH | 1 |
| Buck, WB | 1 |
| Langdana, A | 1 |
| Agarwal, M | 1 |
| Kelgeri, C | 1 |
| Kamat, P | 1 |
| Jones, AL | 1 |
| Proudfoot, AT | 1 |
| Rella, J | 1 |
| McGuigan, MA | 1 |
| Yamada, J | 1 |
| Temmerman, W | 1 |
| Dhondt, A | 1 |
| Vandewoude, K | 1 |
| Cash, JM | 1 |
| Zawada, ET | 1 |
| Brent, J | 1 |
| Vo, N | 1 |
| Kulig, K | 1 |
| Rumack, BH | 1 |
5 reviews available for pyridoxine and Drug Overdose
| Article | Year |
|---|---|
Pyridoxine-dependent seizures: a clinical and biochemical conundrum.
Topics: Drug Overdose; gamma-Aminobutyric Acid; Humans; Pyridoxal Phosphate; Pyridoxine; Seizures | 2003 |
Isoniazid overdose: four case reports and review of the literature.
Topics: Acidosis; Adolescent; Adult; Antitubercular Agents; Drug Overdose; Female; Humans; Isoniazid; Male; | 1995 |
Treatment of acute isoniazid overdose in dogs.
Topics: Administration, Oral; Animals; Anticonvulsants; Antitubercular Agents; Cats; Diazepam; Dog Diseases; | 1995 |
The features and management of poisoning with drugs used to treat Parkinson's disease.
Topics: Antidotes; Antiparkinson Agents; Drug Overdose; Gastric Lavage; Humans; Physostigmine; Pyridoxine | 1997 |
Acute isoniazid intoxication: seizures, acidosis and coma.
Topics: Acidosis; Acute Disease; Adolescent; Antitubercular Agents; Coma; Diagnosis, Differential; Drug Over | 1999 |
15 other studies available for pyridoxine and Drug Overdose
| Article | Year |
|---|---|
Thoracic spine compression fracture during isoniazid-induced seizures: case report.
Topics: Antidotes; Back Pain; Charcoal; Child; Drug Overdose; Epilepsy, Tonic-Clonic; Female; Fractures, Com | 2008 |
Isoniazid-induced status epilepticus in a pediatric patient after inadequate pyridoxine therapy.
Topics: Antitubercular Agents; Diagnosis, Differential; Dose-Response Relationship, Drug; Drug Overdose; Hum | 2010 |
Do not overlook acute isoniazid poisoning in children with status epilepticus.
Topics: Acidosis; Antitubercular Agents; Child, Preschool; Diagnosis, Differential; Diazepam; Drug Overdose; | 2003 |
ACUTE POISONING FROM OVERDOSE OF ISONIAZID; A CASE REPORT.
Topics: Black People; Drug Overdose; Humans; Infant; Isoniazid; Pyridoxine; Seizures; Toxicology | 1963 |
Persisting dementia after isoniazid overdose.
Topics: Adult; Antitubercular Agents; Dementia; Drug Overdose; Humans; Isoniazid; Male; Neurologic Examinati | 2005 |
Acute isoniazid toxicity and the need for adequate pyridoxine supplies.
Topics: Acute Disease; Adult; Antidotes; Antitubercular Agents; Drug Overdose; Drugs, Essential; Humans; Inf | 2006 |
INH-induced neurotoxicity.
Topics: Acidosis; Adult; Brain; Drug Overdose; Humans; Isoniazid; Pyridoxine; Seizures | 1994 |
Mexiletine overdose producing status epilepticus without cardiovascular abnormalities.
Topics: Adult; Blood Pressure; Cardiovascular System; Diazepam; Drug Overdose; Drug Therapy, Combination; El | 1994 |
Isoniazid toxicity: a survey of pyridoxine availability.
Topics: Data Collection; Drug Overdose; Humans; Isoniazid; Pharmacy Service, Hospital; Pyridoxine; Tuberculo | 1994 |
[Pyridoxine for severe metabolic acidosis and seizures due to isoniazid overdose].
Topics: Acidosis; Adolescent; Drug Overdose; Female; Humans; Infusions, Intravenous; Isoniazid; Pyridoxine; | 1993 |
Pyridoxine in acute isoniazid overdose.
Topics: Antitubercular Agents; Child; Child, Preschool; Drug Overdose; Female; Humans; Isoniazid; Pyridoxine | 1996 |
Status epilepticus.
Topics: Drug Overdose; Humans; Isoniazid; Pyridoxine; Status Epilepticus | 1998 |
The geographic distribution of tuberculosis and pyridoxine supply in Ontario.
Topics: Antitubercular Agents; Drug Overdose; Health Services Needs and Demand; Humans; Injections, Intraven | 1995 |
Isoniazid overdose. Successful treatment with pyridoxine and hemodialysis.
Topics: Adolescent; Drug Overdose; Humans; Isoniazid; Male; Poisoning; Pyridoxine; Renal Dialysis | 1991 |
Reversal of prolonged isoniazid-induced coma by pyridoxine.
Topics: Adolescent; Adult; Coma; Drug Overdose; Female; Humans; Isoniazid; Male; Pyridoxine | 1990 |