pyridoxine has been researched along with Down Syndrome in 26 studies
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Some studies of children with Down syndrome have found mild abnormalities in the metabolism of pyridoxine (vitamin B(6)); therefore the present question is whether such abnormalities might also be present in the amniotic fluid of fetuses with Down syndrome." | 7.74 | Pyridoxine-related metabolite concentrations in normal and Down syndrome amniotic fluid. ( Baggot, PJ; DeNicola, NG; Eliseo, AJ; Kalamarides, JA; Shoemaker, JD, 2008) |
| "Some studies of children with Down syndrome have found mild abnormalities in the metabolism of pyridoxine (vitamin B(6)); therefore the present question is whether such abnormalities might also be present in the amniotic fluid of fetuses with Down syndrome." | 3.74 | Pyridoxine-related metabolite concentrations in normal and Down syndrome amniotic fluid. ( Baggot, PJ; DeNicola, NG; Eliseo, AJ; Kalamarides, JA; Shoemaker, JD, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (88.46) | 18.7374 |
| 1990's | 2 (7.69) | 18.2507 |
| 2000's | 1 (3.85) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| JIMENEZESPINOSA, L | 1 |
| LOPEZROSAT, V | 1 |
| GUARDIOLAPLA, J | 1 |
| Baggot, PJ | 1 |
| Eliseo, AJ | 1 |
| DeNicola, NG | 1 |
| Kalamarides, JA | 1 |
| Shoemaker, JD | 1 |
| Pueschel, SM | 2 |
| Reed, RB | 2 |
| Cronk, CE | 2 |
| Goldstein, BI | 1 |
| Cullen, SM | 1 |
| Schnell, RR | 1 |
| Betke, K | 1 |
| Schäfer, KH | 1 |
| Bremer, HJ | 1 |
| Schmid, F | 1 |
| Christeller, S | 1 |
| Rehm, W | 1 |
| Bhagavan, HN | 3 |
| Coleman, M | 5 |
| Coursin, DB | 2 |
| Grimm, U | 1 |
| Knapp, A | 1 |
| Schmitz, W | 1 |
| Smetan, M | 1 |
| Schmitz, KW | 1 |
| Reddemann, H | 1 |
| Schulz, M | 1 |
| Schlenzka, K | 1 |
| Kleijnen, J | 1 |
| Knipschild, P | 1 |
| Coburn, SP | 2 |
| Mahuren, JD | 1 |
| Schaltenbrand, WE | 1 |
| Hestnes, A | 1 |
| Borud, O | 1 |
| Lunde, H | 1 |
| Gjessing, L | 1 |
| Sobel, S | 1 |
| Coursin, D | 1 |
| Marquardt, A | 1 |
| Guay, M | 1 |
| Hunt, C | 1 |
| Frager, J | 1 |
| Barnet, A | 1 |
| Weiss, I | 1 |
| Cocchi, R | 1 |
| Rosenfeld, P | 1 |
| Tu, JB | 1 |
| Zellweger, H | 1 |
| King, JS | 2 |
| Goodman, HO | 2 |
| Thomas, JJ | 2 |
| McCoy, EE | 3 |
| Wehrle, H | 1 |
| Wainer, A | 1 |
| England, J | 1 |
| Seidenberg, M | 1 |
| Colombini, C | 1 |
| Ebadi, M | 1 |
| Mirza, AM | 1 |
| Venugopalan, K | 1 |
| Airaksinen, EM | 1 |
1 review available for pyridoxine and Down Syndrome
| Article | Year |
|---|---|
Niacin and vitamin B6 in mental functioning: a review of controlled trials in humans.
Topics: Adult; Autistic Disorder; Child; Clinical Trials as Topic; Down Syndrome; Humans; Mental Disorders; | 1991 |
4 trials available for pyridoxine and Down Syndrome
| Article | Year |
|---|---|
5-hydroxytryptophan and pyridoxine. Their effects in young children with Down's syndrome.
Topics: Child, Preschool; Clinical Trials as Topic; Double-Blind Method; Down Syndrome; Drug Therapy, Combin | 1980 |
A double blind study of vitamin B6 in Down's syndrome infants. Part 1--Clinical and biochemical results.
Topics: Blister; Body Height; Body Weight; Child; Child, Preschool; Clinical Trials as Topic; Double-Blind M | 1985 |
A double blind study of vitamin B6 in Down's syndrome infants. Part 2--Cortical auditory evoked potentials.
Topics: Child, Preschool; Double-Blind Method; Down Syndrome; Evoked Potentials, Auditory; Humans; Infant; P | 1985 |
Platelet-rich plasma 5-hydroxytryptamine, urinary 5-hydroxyindoleacetic acid and tryptophan ingestion in mongols.
Topics: Adolescent; Adult; Blood Platelets; Blood Specimen Collection; Child; Child, Preschool; Chromosome A | 1971 |
21 other studies available for pyridoxine and Down Syndrome
| Article | Year |
|---|---|
[THE ACTION OF B-85 ON MONGOLISM AND OTHER FORMS OF OLIGOPHRENIA].
Topics: Down Syndrome; Electroencephalography; Intellectual Disability; Meclizine; Pyridoxine | 1963 |
Pyridoxine-related metabolite concentrations in normal and Down syndrome amniotic fluid.
Topics: Amniotic Fluid; Biomarkers; Case-Control Studies; Down Syndrome; Female; Humans; Kynurenine; Oxalic | 2008 |
Social development and feeding milestones of young Down syndrome children.
Topics: 5-Hydroxytryptophan; Child; Down Syndrome; Feeding Behavior; Female; Heart Defects, Congenital; Huma | 1981 |
[Letter: "Basis therapy" and especially "cell therapy" in Down's syndrome].
Topics: Brain; Cell- and Tissue-Based Therapy; Child; Down Syndrome; Humans; Pyridoxine; Taurine; Tryptophan | 1975 |
[Letter: Comment on cell therapy in children with special reference to pediatric-metabolic problems].
Topics: Cell- and Tissue-Based Therapy; Child; Down Syndrome; Humans; Pyridoxine; Taurine; Tryptophan | 1975 |
[Studies on the state of vitamins B1, B2 and B6 in Down's syndrome].
Topics: Alanine Transaminase; Aspartate Aminotransferases; Child; Down Syndrome; Electrolytes; Female; Human | 1975 |
Distribution of pyridoxal-5-phosphate in human blood between the cells and the plasma: effect of oral administration of pyridoxine on the ratio in Down's and hyperactive patients.
Topics: Administration, Oral; Adolescent; Adult; Child; Child, Preschool; Down Syndrome; Female; Humans; Hyp | 1975 |
[Tryptophan metabolism and oligophrenia (author's transl)].
Topics: Amino Acid Metabolism, Inborn Errors; Down Syndrome; Epilepsy; Hartnup Disease; Humans; Intellectual | 1978 |
Increased activity of pyridoxal kinase in tongue in Down's syndrome.
Topics: Adolescent; Adult; Child; Child, Preschool; Down Syndrome; Female; Humans; Male; Middle Aged; Pyrido | 1991 |
Cystathioninuria in Down's syndrome.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Cystathionine; Down Syndrome; Female; Humans; Pyridoxin | 1989 |
Reduction of susceptibility to upper respiratory tract infections in Down syndrome children following treatment with GABAergic drugs: report of 70 cases.
Topics: Benzodiazepines; Child; Disease Susceptibility; Down Syndrome; Female; gamma-Aminobutyric Acid; Glut | 1987 |
Pyridoxal-5-phosphate levels in whole blood in home-reared patients with trisomy 21.
Topics: Adolescent; Child; Child, Preschool; Down Syndrome; Female; Humans; Infant; Male; Pyridoxal Phosphat | 1973 |
Blood-serotonin deficiency in Down's syndrome.
Topics: Adolescent; Blood; Brain; Child; Down Syndrome; Humans; Penicillamine; Pyridoxine; Serotonin; Trypto | 1965 |
Urinary amino acid excretion in mongolism.
Topics: Adolescent; Adult; Aged; Amino Acids; Aminoisobutyric Acids; Child; Child, Preschool; Chromatography | 1966 |
The excretion of taurine during deoxypyridoxine administration in Downs' syndrome patients and controls.
Topics: Adolescent; Antimetabolites; Child; Cysteine; Down Syndrome; Female; Humans; Pyridoxine; Taurine | 1966 |
Factors influencing urinary taurine excretion by normal and mongoloid subjects.
Topics: Age Factors; Analysis of Variance; Body Weight; Chromatography, Ion Exchange; Cysteine; Diet; Dietar | 1968 |
Excretion of 4-pyridoxic acid during deoxypyridoxine and pyridoxine administration to mongoloid and non-mongoloid subjects.
Topics: Adolescent; Antimetabolites; Child; Down Syndrome; Humans; Isonicotinic Acids; Pyridoxine; Time Fact | 1968 |
Leukocyte pyridoxal phosphate and alkaline phosphatase in Down's syndrome and other retardates.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aldehydes; Alkaline Phosphatase; Body Surface Area; Depr | 1969 |
The metabolism of vitamin B6 in Down's syndrome.
Topics: Adolescent; Down Syndrome; Humans; Kynurenine; Male; Oxalates; Pyridoxine; Taurine; Tryptophan; Xant | 1969 |
Vitamin B 6 dependent convulsions manifest in a case of Down's syndrome.
Topics: Down Syndrome; Female; Humans; Infant, Newborn; Male; Metabolism, Inborn Errors; Pyridoxine; Seizure | 1972 |
Infantile spasms associated with 5-hydroxytryptophan administration in patients with Down's syndrome.
Topics: 5-Hydroxytryptophan; Adrenocorticotropic Hormone; Brain; Down Syndrome; Electroencephalography; Huma | 1971 |