pyridoxine has been researched along with Depression in 67 studies
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dosage of Vitamin-B6 from 20-50 mg given daily to women suffering from depression helped in many cases." | 6.35 | [Depression, contraceptive pills and pyridoxine (vitamin B6)]. ( Bergsjo, P, 1974) |
| " This letter-writer argues that the salient action of mood elevation is a result of the supplemental pyridoxine (vitamin B) which ameliorates the deficiency induced by oral contraceptive use that leads to depression resulting from inhibition of synthesis of biogenic amines in the central nervous system." | 3.65 | Letter: supplementary pyridoxine given to women using oral contraceptives. ( Winston, F, 1975) |
| "Few studies on adult and pediatric patients have shown pyridoxine efficacy as additional therapy for those receiving levetiracetam (LEV) to prevent and mitigate behavioral adverse effects (BAEs)." | 2.87 | Pyridoxine Add-On Treatment for the Control of Behavioral Adverse Effects Induced by Levetiracetam in Children: A Case-Control Prospective Study. ( Falsaperla, R; Marino, S; Marino, SD; Pavone, P; Provvidenti, S; Romano, C; Vitaliti, G, 2018) |
| " Is pyridoxine safe for long-term use in large segments of the population, including children? The studies on children with Down's syndrome and autism, utilizing much higher doses than are used for other therapeutic purposes, seem to indicate relative safety if carefully monitored." | 2.38 | Vitamin B6 in clinical neurology. ( Bernstein, AL, 1990) |
| "Premenstrual syndrome is of interest to health care professionals today because of media attention and large numbers of women who are concerned about their premenstrual symptoms." | 1.27 | Premenstrual syndrome: concerns, controversies, and treatment. ( Falko, JM; Friedman, CI; O'Shaughnessy, RW; Pariser, SF; Shank, ML; Stern, SL, 1985) |
| "Clinical effects due to vitamin deficiency have been described for vitamin B6--namely, depression and impaired glucose tolerance." | 1.25 | Vitamins and oral contraceptive use. ( Wynn, V, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 55 (82.09) | 18.7374 |
| 1990's | 3 (4.48) | 18.2507 |
| 2000's | 6 (8.96) | 29.6817 |
| 2010's | 2 (2.99) | 24.3611 |
| 2020's | 1 (1.49) | 2.80 |
| Authors | Studies |
|---|---|
| Maratha, S | 1 |
| Sharma, V | 1 |
| Walia, V | 1 |
| Marino, S | 1 |
| Vitaliti, G | 1 |
| Marino, SD | 1 |
| Pavone, P | 1 |
| Provvidenti, S | 1 |
| Romano, C | 1 |
| Falsaperla, R | 1 |
| Moore, K | 1 |
| Hughes, CF | 1 |
| Hoey, L | 1 |
| Ward, M | 1 |
| Cunningham, C | 1 |
| Molloy, AM | 1 |
| Strain, JJ | 1 |
| McCarroll, K | 1 |
| Casey, MC | 1 |
| Tracey, F | 1 |
| Laird, E | 1 |
| O'Kane, M | 1 |
| McNulty, H | 1 |
| Torshin, IIu | 1 |
| Gromova, OA | 1 |
| Gusev, EI | 1 |
| Gaby, AR | 1 |
| Iezhitsa, IN | 1 |
| Onishchenko, NV | 1 |
| Churbakova, NV | 1 |
| Parshev, VV | 1 |
| Petrov, VI | 1 |
| Spasov, AA | 1 |
| KLEIN, JR | 1 |
| ACUNA, JC | 1 |
| WAARDENBURG, HA | 1 |
| REZNIK, SE | 1 |
| VILDERMAN, AM | 1 |
| Tolmunen, T | 1 |
| Voutilainen, S | 1 |
| Hintikka, J | 1 |
| Rissanen, T | 1 |
| Tanskanen, A | 1 |
| Viinamäki, H | 1 |
| Kaplan, GA | 1 |
| Salonen, JT | 1 |
| Merrill, RM | 1 |
| Taylor, P | 1 |
| Aldana, SG | 1 |
| Young, SN | 1 |
| Chouinard, G | 1 |
| Annable, L | 1 |
| Elsborg, L | 1 |
| Vendittelli, F | 1 |
| Alain, J | 1 |
| Nouaille, Y | 1 |
| Brosset, A | 1 |
| Tabaste, JL | 1 |
| Bender, DA | 2 |
| Lombard, CB | 1 |
| Wynn, V | 4 |
| Coppen, A | 1 |
| Møller, SE | 1 |
| Brush, MG | 1 |
| Taylor, RW | 1 |
| Livingston, JE | 1 |
| MacLeod, PM | 1 |
| Applegarth, DA | 1 |
| Ovesen, L | 1 |
| Pulkkinen, MO | 1 |
| Salminen, J | 1 |
| Virtanen, S | 1 |
| Anderson, KE | 1 |
| Bodansky, O | 1 |
| Kappas, A | 1 |
| Kane, FJ | 1 |
| Kellner, H | 1 |
| Dodić, V | 1 |
| Timotijević-Marković, I | 1 |
| Bonević, A | 1 |
| Larsson-Cohn, U | 2 |
| Adams, PW | 3 |
| Folkard, J | 3 |
| Seed, M | 3 |
| Clements, FW | 1 |
| Winston, F | 5 |
| Patt, V | 1 |
| Feltkamp, H | 1 |
| de León, R | 1 |
| Bernstein, AL | 1 |
| Reynolds, RD | 1 |
| Styer, DJ | 1 |
| Schlichting, CL | 1 |
| Abbott, MH | 1 |
| Folstein, SE | 1 |
| Abbey, H | 1 |
| Pyeritz, RE | 1 |
| Pariser, SF | 1 |
| Stern, SL | 1 |
| Shank, ML | 1 |
| Falko, JM | 1 |
| O'Shaughnessy, RW | 1 |
| Friedman, CI | 1 |
| Beaconsfield, P | 1 |
| Rainsbury, R | 1 |
| Ginsburg, J | 1 |
| Davis, RE | 1 |
| Smith, BK | 1 |
| Rose, DP | 2 |
| Strong, R | 1 |
| Rich, H | 1 |
| Luhby, AL | 1 |
| Babikian, HM | 1 |
| Gordon, M | 1 |
| Price, SA | 1 |
| Toseland, PA | 1 |
| Baumblatt, MJ | 1 |
| Morris, JS | 2 |
| Ajdukiewicz, AB | 2 |
| Read, AE | 2 |
| Garcia-Webb, P | 1 |
| Briggs, MH | 1 |
| Leeton, J | 1 |
| Bergsjo, P | 1 |
| Frazer, A | 1 |
| Pandey, GN | 1 |
| Mendels, J | 1 |
| Gehlen, W | 1 |
| Sizaret, P | 1 |
| Degiovanni, A | 1 |
| Lipman, IJ | 1 |
| Kutschera, E | 1 |
| Zettler, H | 1 |
| Knebel, B | 1 |
| Bowers, MB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assesment of Vitamin B6 Level in Patients With Major Depressive Disorder[NCT05649293] | 94 participants (Anticipated) | Observational | 2023-04-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 reviews available for pyridoxine and Depression
| Article | Year |
|---|---|
[Mechanisms of antistress and antidepressive effects of magnesium and pyridoxine].
Topics: Brain; Depression; Humans; Magnesium; Magnesium Compounds; Pyridoxine; Stress, Psychological; Treatm | 2009 |
Non-nutritional uses of vitamin B6.
Topics: Animals; Carpal Tunnel Syndrome; Depression; Drug Interactions; Female; Glucose Tolerance Test; Homo | 1999 |
Effects of oral contraceptives on vitamin metabolism.
Topics: Ascorbic Acid; Blood Platelets; Contraceptives, Oral; Depression; Female; Folic Acid; Humans; Leukoc | 1976 |
Evaluation of emotional reactions to oral contraceptive use.
Topics: Ascorbic Acid; Biogenic Amines; Clinical Trials as Topic; Contraceptives, Oral; Depression; Dose-Res | 1976 |
Oral contraceptives and vitamins: a review.
Topics: Ascorbic Acid; Contraceptives, Oral; Depression; Estradiol Congeners; Female; Folic Acid; Folic Acid | 1975 |
Tryptophan, depression and steroidal contraception.
Topics: Brain; Contraceptives, Oral; Contraceptives, Oral, Combined; Depression; Female; Humans; Pyridoxine; | 1975 |
Vitamin B6 in clinical neurology.
Topics: Animals; Carpal Tunnel Syndrome; Chronic Disease; Depression; Headache; Humans; Movement Disorders; | 1990 |
Aspects of tryptophan metabolism in health and disease: a review.
Topics: Brain; Breast Neoplasms; Contraceptives, Oral; Depression; Endocrine System Diseases; Female; Glucoc | 1972 |
[Oral contraceptives and vitamins].
Topics: Animals; Ascorbic Acid; Blood Glucose; Contraceptives, Oral; Depression; Depression, Chemical; Estro | 1974 |
[Depression, contraceptive pills and pyridoxine (vitamin B6)].
Topics: Contraceptives, Oral; Depression; Drug Combinations; Female; Humans; Pyridoxine | 1974 |
L-dopa therapy in Parkinson's disease.
Topics: Delirium; Depression; Dihydroxyphenylalanine; Gastrointestinal Hemorrhage; Hallucinations; Humans; H | 1971 |
8 trials available for pyridoxine and Depression
| Article | Year |
|---|---|
Pyridoxine Add-On Treatment for the Control of Behavioral Adverse Effects Induced by Levetiracetam in Children: A Case-Control Prospective Study.
Topics: Adolescent; Adult; Aggression; Anticonvulsants; Child; Child Behavior; Child, Preschool; Confusion; | 2018 |
Coronary Health Improvement Project (CHIP) is associated with improved nutrient intake and decreased depression.
Topics: Adult; Aged; Aged, 80 and over; Coronary Disease; Depression; Dietary Fats; Female; Follow-Up Studie | 2008 |
Letter: Treatment of unpolar depression.
Topics: Ascorbic Acid; Depression; Drug Therapy, Combination; Humans; Pyridoxine; Tryptophan | 1976 |
Evaluation of emotional reactions to oral contraceptive use.
Topics: Ascorbic Acid; Biogenic Amines; Clinical Trials as Topic; Contraceptives, Oral; Depression; Dose-Res | 1976 |
[Treatment of cerebral degenerative symptoms due to age. Double blind trial on the effect of Juston (author's transl)].
Topics: Activities of Daily Living; Aged; Aging; Ascorbic Acid; Cachexia; Central Nervous System Diseases; D | 1975 |
Decreased vitamin B-6 status of submariners during prolonged patrol.
Topics: Adult; Depression; Humans; Male; Pyridoxal Phosphate; Pyridoxic Acid; Pyridoxine; Submarine Medicine | 1988 |
Effect of pyridoxine hydrochloride (vitamin B 6 ) upon depression associated with oral contraception.
Topics: Adult; Amines; Brain; Clinical Trials as Topic; Contraceptives, Oral; Depression; Erythrocytes; Estr | 1973 |
Letter: Vitamin B 6, depression, and oral contraception.
Topics: Clinical Trials as Topic; Contraceptives, Oral; Depression; Female; Humans; Placebos; Pyridoxine; Vi | 1974 |
49 other studies available for pyridoxine and Depression
| Article | Year |
|---|---|
Possible involvement of NO-sGC-cGMP signaling in the antidepressant like effect of pyridoxine in mice.
Topics: Animals; Antidepressive Agents; Arginine; Cyclic GMP; Depression; Mice; Nitric Oxide; Pyridoxine; So | 2022 |
B-vitamins in Relation to Depression in Older Adults Over 60 Years of Age: The Trinity Ulster Department of Agriculture (TUDA) Cohort Study.
Topics: Aged; Aging; Biomarkers; Cognitive Dysfunction; Cohort Studies; Cross-Sectional Studies; Depression; | 2019 |
Intravenous nutrient therapy: the "Myers' cocktail".
Topics: Administration, Oral; Adult; Aged; Ascorbic Acid; Asthma; Body Temperature; Calcium Gluconate; Child | 2002 |
Effect of magnesium supplementation containing mineral bishofit (MgCl2 x 6H2O) solution and pyridoxine hydrochloride on erythrocyte magnesium depletion and behaviour of rats after three-month alcoholization.
Topics: Alcohol Drinking; Animals; Behavior, Animal; Central Nervous System Depressants; Depression; Dietary | 2002 |
Depression of heme formation and production of free porphyrin in duck erythrocytes.
Topics: Adenine; Animals; Benzimidazoles; Chloramphenicol; Depression; Depressive Disorder; Ducks; Erythrocy | 1962 |
[THERAPEUTIC APPLICATIONS OF HYDROXOCOBALAMINE, THIAMINE AND PYRIDOXINE IN A CONJOINED FORM].
Topics: Anemia; Child; Depression; Depressive Disorder; Feeding and Eating Disorders; Geriatrics; Humans; Hy | 1963 |
[SUICIDE AFTER PROLONGED USE OF CYCLOSERINE].
Topics: Cycloserine; Depression; Depressive Disorder; Ethionamide; Isoniazid; Pyridoxine; Suicide; Toxicolog | 1964 |
[USE OF PYRIDOXINE IN THE TREATMENT OF SIDE EFFECTS OF ANTITUBERCULAR AGENTS].
Topics: Antitubercular Agents; Cycloserine; Depression; Drug Therapy; Eye Manifestations; Isoniazid; Paresth | 1963 |
Dietary folate and depressive symptoms are associated in middle-aged Finnish men.
Topics: Adult; Alcohol Drinking; Appetite; Body Mass Index; Cross-Sectional Studies; Depression; Diet; Dieta | 2003 |
Tryptophan in the treatment of depression.
Topics: Allopurinol; Antidepressive Agents, Tricyclic; Ascorbic Acid; Bipolar Disorder; Depression; Electroc | 1981 |
[P-pills, depression and vitamin B6].
Topics: Contraceptives, Oral; Contraceptives, Oral, Hormonal; Depression; Female; Humans; Pyridoxine | 1982 |
A case of lipomeningocele reported with fluoxetine (and alprazolam, vitamins B1 and B6, heptaminol) prescribed during pregnancy.
Topics: Adult; Alprazolam; Depression; Drug Therapy, Combination; Female; Fluoxetine; Heptaminol; Humans; In | 1995 |
What is the role of food in preventing depression and improving mood, performance and cognitive function?
Topics: Affect; Cognition; Depression; Diet; Female; Humans; Nutritional Physiological Phenomena; Pyridoxine | 2000 |
Vitamins and oral contraceptive use.
Topics: Anemia, Megaloblastic; Ascorbic Acid; Avitaminosis; Coenzymes; Contraceptives, Oral; Depression; Fem | 1975 |
[Tryptophan. Peripheral regulation of central function].
Topics: Adrenal Cortex Hormones; Brain; Depression; Estrogens; Female; Humans; Pain; Pyridoxine; Serotonin; | 1979 |
Depression in men and women.
Topics: Depression; Dydrogesterone; Estradiol; Female; Humans; Male; Premenstrual Syndrome; Progesterone; Pr | 1977 |
Vitamin B6 status in women with postpartum depression.
Topics: Adolescent; Adult; Aspartate Aminotransferases; Depression; Enzyme Activation; Female; Humans; Pregn | 1978 |
[Oral contraceptives and vitamin B 6].
Topics: Contraceptives, Oral; Depression; Female; Glucose; Humans; Pyridoxine; Vitamin B 6 Deficiency | 1978 |
Depression and oral contraceptives: the role of pyridoxine.
Topics: Contraceptives, Oral; Depression; Female; Humans; Pyridoxine | 1978 |
Serum vitamin B6 in pure pregnancy depression.
Topics: Adult; Depression; Female; Humans; Pregnancy; Pregnancy Complications; Psychological Tests; Pyridoxi | 1978 |
[Oral contraceptive agents, pyridoxine and depression].
Topics: Contraceptives, Oral; Depression; Drug Synergism; Female; Humans; Pyridoxine | 1976 |
Nutrition 7. Vitamin and mineral supplementation.
Topics: Adult; Aged; Ascorbic Acid; Ascorbic Acid Deficiency; Burns; Child; Contraceptives, Oral; Depression | 1975 |
Letter: supplementary pyridoxine given to women using oral contraceptives.
Topics: Contraceptives, Oral; Depression; Female; Humans; Pyridoxine; Vitamin B 6 Deficiency | 1975 |
[Hormonal contraception, tryptophan metabolism and depression].
Topics: Contraceptives, Oral; Depression; Female; Humans; Kynurenic Acid; Pyridoxine; Tryptophan; Xanthurena | 1975 |
[Piriglutine (conductase): clinical use in 500 cases of anesthesia and resuscitation. Initial report (summary)].
Topics: Adult; Aged; Brain; Depression; Drug Evaluation; Female; Glutarates; Humans; Male; Middle Aged; Post | 1976 |
Psychiatric manifestations of homocystinuria due to cystathionine beta-synthase deficiency: prevalence, natural history, and relationship to neurologic impairment and vitamin B6-responsiveness.
Topics: Cystathionine beta-Synthase; Depression; Homocystinuria; Humans; Hydro-Lyases; Intelligence; Mood Di | 1987 |
Premenstrual syndrome: concerns, controversies, and treatment.
Topics: Antidepressive Agents; Bromocriptine; Cyclooxygenase Inhibitors; Danazol; Depression; Diuretics; Est | 1985 |
Uptake of tryptophan into the brain: dietary influences on serotoninergic function.
Topics: Animals; Appetite Regulation; Brain; Depression; Diet; Humans; Kinetics; Protein Binding; Pyridoxine | 1986 |
Correlation of experimental and clinical investigation of the pill.
Topics: Animals; Contraceptive Agents; Depression; Disease Models, Animal; Female; Humans; Pyridoxine | 1973 |
Pyridoxine and depression associated with oral contraception.
Topics: Adult; Contraceptives, Oral; Depression; Female; Humans; Middle Aged; Pyridoxal; Pyridoxine | 1973 |
Letter: Misuse of the chi-squared test.
Topics: Depression; Female; Humans; Placebos; Pyridoxine; Statistics as Topic; Vitamin B 6 Deficiency | 1974 |
Oral contraceptives and depression.
Topics: Contraceptives, Oral; Depression; Female; Humans; Menstruation; Pregnancy; Pyridoxine; Tryptophan | 1969 |
Oral contraceptives and depression.
Topics: Contraceptives, Oral; Depression; Female; Humans; Pyridoxine; Tryptophan | 1969 |
Oral contraceptives and depression.
Topics: Adult; Contraceptives, Oral; Depression; Female; Humans; Pyridoxine | 1969 |
Pyridoxine and the pill.
Topics: Adult; Contraceptives, Oral; Depression; Emotions; Ethynodiol Diacetate; Fatigue; Female; Humans; Ly | 1970 |
Neurological disorders and adult coeliac disease.
Topics: Action Potentials; Adult; Aged; Anemia; Calcium; Celiac Disease; Depression; Diet; Epilepsy; Female; | 1970 |
Letter: Hypertension and depression.
Topics: Antidepressive Agents; Contraceptives, Oral; Depression; Female; Humans; Hypertension; Pyridoxine | 1973 |
Depression induced by oral contraception and the role of vitamin B6 in its management.
Topics: 5-Hydroxytryptophan; Contraceptives, Oral; Depression; Female; Humans; Pyridoxine; Serotonin; Trypto | 1974 |
Metabolism of tryptophan in depressive disease.
Topics: Adult; Bipolar Disorder; Depression; Humans; Hydroxyindoleacetic Acid; Kynurenine; Male; Metabolic C | 1973 |
Editorial: Depression and the pill.
Topics: Contraceptives, Oral; Depression; Female; Humans; Pyridoxine | 1973 |
Oral contraceptives, pyridoxine, and depression.
Topics: Animals; Brain Chemistry; Contraceptives, Oral; Depression; Estrogens; Female; Humans; Kynurenine; N | 1973 |
[Differential treatment of Parkinson's disease, with special reference to the possibility of iatrogenic disorders (author's transl)].
Topics: Amantadine; Anesthetics; Anti-Bacterial Agents; Antidepressive Agents; Antihypertensive Agents; Anti | 1974 |
Editorial: Vitamins and the pill.
Topics: Anemia, Macrocytic; Ascorbic Acid; Ascorbic Acid Deficiency; Contraceptives, Oral; Depression; Femal | 1974 |
[A case of so-called late dyskinetic syndrome appearing early during neuroleptic treatment].
Topics: Depression; Humans; Movement Disorders; Phenothiazines; Piperidines; Pyridoxine; Sulfonamides; Tranq | 1974 |
[Treatment of restlessness and depressive conditions in children].
Topics: Adolescent; Child; Child, Preschool; Chlorprothixene; Depression; Drug Combinations; Female; Humans; | 1972 |
[Pseudoneurasthenia and EEG chenges due to vitamin B 6 deficiency during INH therapy].
Topics: Adult; Affective Symptoms; Antitubercular Agents; Carboxy-Lyases; Depression; Electroencephalography | 1971 |
Oral contraception and depression.
Topics: Contraceptives, Oral; Depression; Female; Humans; Pyridoxine | 1969 |
Pyridoxine deficiency in celiac disease and the detection of neuropsychiatric disorders.
Topics: Adult; Aged; Celiac Disease; Depression; Female; Humans; Male; Middle Aged; Nervous System Diseases; | 1969 |
Cerebrospinal fluid 5-hydroxyindoles and behavior after L-tryptophan and pyridoxine adminstration to psychiatric patients.
Topics: Adolescent; Adult; Behavior; Depression; Female; Humans; Indoles; Male; Middle Aged; Psychological T | 1970 |