pyridoxine has been researched along with Complications, Pregnancy in 165 studies
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report information about an unpublished 1970s study ("8-way" Bendectin Study) that aimed to evaluate the relative therapeutic efficacy of doxylamine, pyridoxine, and dicyclomine in the management of nausea and vomiting during pregnancy." | 9.24 | 8-Way Randomized Controlled Trial of Doxylamine, Pyridoxine and Dicyclomine for Nausea and Vomiting during Pregnancy: Restoration of Unpublished Information. ( Persaud, N; Zhang, R, 2017) |
| "Doxylamine succinate-pyridoxine hydrochloride delayed release combination is safe and well tolerated by pregnant women when used in the recommended dose of up to 4 tablets daily in treating nausea and vomiting of pregnancy." | 9.20 | Maternal safety of the delayed-release doxylamine and pyridoxine combination for nausea and vomiting of pregnancy; a randomized placebo controlled trial. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Matok, I; Mattison, DR; Miodovnik, M; Umans, JG, 2015) |
| " The authors' objective is to identify the determinants of adherence to delayed-release doxylamine-pyridoxine (Diclectin) in patients with nausea and vomiting of pregnancy (NVP)." | 9.16 | Determinants of adherence to delayed-release doxylamine and pyridoxine in patients with nausea and vomiting of pregnancy. ( Caritis, S; Chiossi, G; Clark, S; Costantine, MM; Hankins, GD; Koren, G; Matok, I; Miodovnik, M; Umans, JG, 2012) |
| "Diclectin delayed release formulation of doxylamine succinate and pyridoxine hydrochloride is effective and well tolerated in treating nausea and vomiting of pregnancy." | 9.14 | Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Mattison, DR; Miodovnik, M; Umans, JG, 2010) |
| "Pyridoxine is effective in relieving the severity of nausea in early pregnancy." | 9.08 | Pyridoxine for nausea and vomiting of pregnancy: a randomized, double-blind, placebo-controlled trial. ( Ruangsri, R; Vutyavanich, T; Wongtra-ngan, S, 1995) |
| "Diclectin (pyridoxine 10 mg and doxylamine 10 mg) has traditionally been used to treat nausea and vomiting of pregnancy (NVP); however, this drug is unavailable in many countries." | 7.79 | Evaluation of the efficacy and safety of bi-daily combination therapy with pyridoxine and doxylamine for nausea and vomiting of pregnancy. ( Ashkenazi-Hoffnung, L; Klinger, G; Merlob, P; Stahl, B, 2013) |
| "A delayed-release combination of doxylamine-pyridoxine (D-P) (Diclectin) is the only approved antiemetic medication for use in pregnancy in Canada." | 7.71 | The safety of higher than standard dose of doxylamine-pyridoxine (Diclectin) for nausea and vomiting of pregnancy. ( Atanackovic, G; Koren, G; Moretti, ME; Navioz, Y, 2001) |
| " The pregnancy was complicated by chronic maternal schizophrenia, severe toxaemia and maternal use of fluphenazine enanthate, dicyclomine hydrochloride, doxylamine succinate, pyridoxine hydrochloride and other drugs." | 7.66 | Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy. ( Bury, RG; Donaldson, GL, 1982) |
| "An effective and safe treatment for nausea and vomiting of pregnancy (NVP) is lacking." | 7.30 | Acupuncture and Doxylamine-Pyridoxine for Nausea and Vomiting in Pregnancy : A Randomized, Controlled, 2 ( An, CM; Cao, YJ; Chen, XY; Cong, J; Cui, YM; Feng, YH; Gao, JS; Hu, YH; Li, J; Li, L; Liu, JP; Liu, L; Liu, YX; Liu, ZL; Liu, ZS; Lu, ZL; Ma, HL; Mol, BWJ; Ng, EHY; Painter, RC; Qi, X; Qin, HC; Wang, CC; Wang, Y; Wang, YX; Wu, Q; Wu, XK; Yan, Y; Yang, XM; Yu, L; Zhang, B; Zhou, LL, 2023) |
| "We report information about an unpublished 1970s study ("8-way" Bendectin Study) that aimed to evaluate the relative therapeutic efficacy of doxylamine, pyridoxine, and dicyclomine in the management of nausea and vomiting during pregnancy." | 5.24 | 8-Way Randomized Controlled Trial of Doxylamine, Pyridoxine and Dicyclomine for Nausea and Vomiting during Pregnancy: Restoration of Unpublished Information. ( Persaud, N; Zhang, R, 2017) |
| "Doxylamine succinate-pyridoxine hydrochloride delayed release combination is safe and well tolerated by pregnant women when used in the recommended dose of up to 4 tablets daily in treating nausea and vomiting of pregnancy." | 5.20 | Maternal safety of the delayed-release doxylamine and pyridoxine combination for nausea and vomiting of pregnancy; a randomized placebo controlled trial. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Matok, I; Mattison, DR; Miodovnik, M; Umans, JG, 2015) |
| " The authors' objective is to identify the determinants of adherence to delayed-release doxylamine-pyridoxine (Diclectin) in patients with nausea and vomiting of pregnancy (NVP)." | 5.16 | Determinants of adherence to delayed-release doxylamine and pyridoxine in patients with nausea and vomiting of pregnancy. ( Caritis, S; Chiossi, G; Clark, S; Costantine, MM; Hankins, GD; Koren, G; Matok, I; Miodovnik, M; Umans, JG, 2012) |
| "Diclectin delayed release formulation of doxylamine succinate and pyridoxine hydrochloride is effective and well tolerated in treating nausea and vomiting of pregnancy." | 5.14 | Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial. ( Caritis, SN; Clark, S; Hankins, GD; Koren, G; Mattison, DR; Miodovnik, M; Umans, JG, 2010) |
| "This study compares pyridoxine-metoclopramide combination therapy to prochlorperazine and promethazine monotherapies in the outpatient treatment of nausea and vomiting in pregnancy." | 5.10 | Comparison of three outpatient regimens in the management of nausea and vomiting in pregnancy. ( Bsat, FA; Hoffman, DE; Seubert, DE, 2003) |
| "Pyridoxine is effective in relieving the severity of nausea in early pregnancy." | 5.08 | Pyridoxine for nausea and vomiting of pregnancy: a randomized, double-blind, placebo-controlled trial. ( Ruangsri, R; Vutyavanich, T; Wongtra-ngan, S, 1995) |
| "Fifty-nine women completed a randomized, double-blind placebo-controlled study of pyridoxine hydrochloride (vitamin B6) for the treatment of nausea and vomiting of pregnancy." | 5.07 | Vitamin B6 is effective therapy for nausea and vomiting of pregnancy: a randomized, double-blind placebo-controlled study. ( Niebyl, J; Rose, N; Rouse, D; Sahakian, V; Sipes, S, 1991) |
| "A double-blind comparison was undertaken between Debendox with 10mg of extra pyridoxine and placebo with 10mg of pyridoxine, in 56 women suffering from nausea and/or vomiting during the first 10 weeks of pregnancy." | 5.04 | Treatment of pregnancy sickness. ( Wheatley, D, 1977) |
| "5, 4, and 10 mg of pyridoxine supplementation during pregnancy on maternal and fetal plasma levels of pyridoxal 5'-phosphate (PLP) and on the degree of coenzyme saturation (activation factor) of aspartate aminotransferase and alanine aminotransferase (alphaEGOT and alphaEGPT) in maternal erythrocytes." | 5.04 | Adequacy of vitamin B6 supplementation during pregnancy: a prospective study. ( Cleary, RE; Lumeng, L; Wagner, R, 1976) |
| "For mild symptoms of nausea and emesis of pregnancy, ginger, pyridoxine, antihistamines, and metoclopramide were associated with greater benefit than placebo." | 4.93 | Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review. ( Beyer, F; Bradley, J; Bryant, A; McParlin, C; Moloney, E; Muirhead, CR; Nelson-Piercy, C; Newbury-Birch, D; Norman, J; O'Donnell, A; Robson, SC; Shaw, C; Simpson, E; Swallow, B; Vale, L; Yates, L, 2016) |
| "Diclectin (pyridoxine 10 mg and doxylamine 10 mg) has traditionally been used to treat nausea and vomiting of pregnancy (NVP); however, this drug is unavailable in many countries." | 3.79 | Evaluation of the efficacy and safety of bi-daily combination therapy with pyridoxine and doxylamine for nausea and vomiting of pregnancy. ( Ashkenazi-Hoffnung, L; Klinger, G; Merlob, P; Stahl, B, 2013) |
| "Diclectin, composed of 10 mg doxylamine succinate (DOX) and 10 mg pyridoxine hydrochloride, is the drug combination of choice for the management of nausea and vomiting during pregnancy in Canada." | 3.77 | Systemic bioavailability and pharmacokinetics of the doxylamine-pyridoxine delayed-release combination (Diclectin). ( Garcia-Bournissen, F; Gill, SK; Koren, G, 2011) |
| "Women who called the Motherisk NVP helpline, and were taking only Diclectin (vitamin B6 10 mg and doxylamine 10 mg), were enrolled in the study and assessed for the severity of nausea and vomiting of pregnancy (NVP) with the Motherisk-PUQE (pregnancy-unique quantification of emesis and nausea) scoring system." | 3.72 | Diclectin therapy for nausea and vomiting of pregnancy: effects of optimal dosing. ( Boskovic, R; Einarson, A; Koren, G; Maltepe, C; Wolpin, J, 2003) |
| "A delayed-release combination of doxylamine-pyridoxine (D-P) (Diclectin) is the only approved antiemetic medication for use in pregnancy in Canada." | 3.71 | The safety of higher than standard dose of doxylamine-pyridoxine (Diclectin) for nausea and vomiting of pregnancy. ( Atanackovic, G; Koren, G; Moretti, ME; Navioz, Y, 2001) |
| ", folate, cobalamin, or pyridoxine) potentiated by maternal dietary deficiency of these cofactors and by pregnancy." | 3.70 | DNA polymorphism-diet-cofactor-development hypothesis and the gene-teratogen model for schizophrenia and other developmental disorders. ( Johnson, WG, 1999) |
| " Whenever she decreases her prednisone dose, her nausea increases tremendously even though she is taking two tablets of doxylamine and pyridoxine combination (Diclectin) daily." | 3.70 | Managing women with nausea and vomiting of pregnancy. Canadian consensus. ( , 2000) |
| " Although no definitive causative factor has been identified in previously reported cases, the affection in our case is possibly related to Debendox (Bendectin) and nitrofurantoin taken in early pregnancy for nausea and renal tract infection, respectively." | 3.69 | Congenital symmetrical weakness of the upper limbs resembling brachial plexus palsy: a possible sequel of drug toxicity in first trimester of pregnancy? ( Dubowitz, V; Muntoni, F; Philpot, J; Skellett, S, 1995) |
| "The antinausea drug combination, doxylamine/dicyclomine/pyridoxine (Debendox or Bendectin [US] ), has been withdrawn from the market because of litigation based upon charges that it causes congenital limb defects." | 3.67 | The innocent bystander. Doxylamine/dicyclomine/pyridoxine and congenital limb defects. ( Elliott, J; Forrest, J; Kricker, A; McCredie, J, 1984) |
| " Methionine restriction initiated neonatally prevented mental retardation, retarded the rate of lens dislocation, and may have reduced the incidence of seizures." | 3.67 | The natural history of homocystinuria due to cystathionine beta-synthase deficiency. ( Andria, G; Boers, GH; Bromberg, IL; Cerone, R; Levy, HL; Mudd, SH; Pettigrew, KD; Pyeritz, RE; Skovby, F; Wilcken, B, 1985) |
| "In my practice, vitamin B6 (pyridoxine) therapy (100 to 200 mg daily for 12 weeks) has proved curative for a large percentage of patients having carpal tunnel syndrome (CTS)." | 3.67 | Treatment of carpal tunnel syndrome with vitamin B6. ( Ellis, JM, 1987) |
| " The pregnancy was complicated by chronic maternal schizophrenia, severe toxaemia and maternal use of fluphenazine enanthate, dicyclomine hydrochloride, doxylamine succinate, pyridoxine hydrochloride and other drugs." | 3.66 | Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy. ( Bury, RG; Donaldson, GL, 1982) |
| "The vitamin B6 nutriture was determined during pregnancy beginning at month II until term by means of determination of pyridoxal phosphate in serum of 16 healthy pregnant women." | 3.66 | Vitamin B6 nutriture during pregnancy. ( Dapunt, O; Reinken, L, 1978) |
| "An effective and safe treatment for nausea and vomiting of pregnancy (NVP) is lacking." | 3.30 | Acupuncture and Doxylamine-Pyridoxine for Nausea and Vomiting in Pregnancy : A Randomized, Controlled, 2 ( An, CM; Cao, YJ; Chen, XY; Cong, J; Cui, YM; Feng, YH; Gao, JS; Hu, YH; Li, J; Li, L; Liu, JP; Liu, L; Liu, YX; Liu, ZL; Liu, ZS; Lu, ZL; Ma, HL; Mol, BWJ; Ng, EHY; Painter, RC; Qi, X; Qin, HC; Wang, CC; Wang, Y; Wang, YX; Wu, Q; Wu, XK; Yan, Y; Yang, XM; Yu, L; Zhang, B; Zhou, LL, 2023) |
| "Nausea and vomiting are common in early pregnancy." | 2.50 | The pharmacologic management of nausea and vomiting of pregnancy. ( Briggs, GG; Niebyl, JR, 2014) |
| "Nausea and vomiting affects a large proportion of women in early pregnancy, yet because it is a physiological symptom it is often dismissed by health professionals, leaving women to find their own coping mechanisms." | 2.41 | Nausea and vomiting in pregnancy: safety and efficacy of self-administered complementary therapies. ( Tiran, D, 2002) |
| " Pyridoxine is considered safe for use during pregnancy, but its efficacy in treating nausea and vomiting has not been determined." | 2.37 | Safety and efficacy of antiemetics used to treat nausea and vomiting in pregnancy. ( Leathem, AM, 1986) |
| " Thus, in France, as in other countries, vitamin B6 could be integrated into the therapeutic arsenal of mild to moderate nausea and vomiting during pregnancy according to the following dosage schedule: oral intake of 10mg four times a day of a compounded preparation of vitamin B6, alone or in combination with doxylamine." | 1.56 | [Interest of vitamin b6 for treatment of nausea and/or vomiting during pregnancy]. ( Pecriaux, C, 2020) |
| "Case infants (n = 998) had nonsyndromic congenital heart defects and control infants (n = 3,029) had no congenital defects." | 1.30 | Nausea during pregnancy and congenital heart defects: a population-based case-control study. ( Boneva, RS; Botto, L; Erickson, JD; Moore, CA; Wong, LY, 1999) |
| "Eleven days after a caesarean section cerebral infarction was diagnosed." | 1.28 | Cerebral infarction after caesarean section due to heterozygosity for homocystinuria; a case report. ( Boers, GH; de Wit, PH; Minkhorst, AG; van Dongen, PW, 1991) |
| "Two hundred cases of verified brain tumors occurring in patients under 15 years of age were studied in relation to possible etiologic, genetic, and environmental risk factors." | 1.28 | Potential risk factors for brain tumors in children. An analysis of 200 cases. ( Giuffrè, R; Liccardo, G; Pastore, FS; Spallone, A; Vagnozzi, R, 1990) |
| " No dose-response relationship was evident." | 1.27 | Inter-Regional Epidemiological Study of Childhood Cancer (IRESCC): childhood cancer and the consumption of debendox and related drugs in pregnancy. ( Birch, JM; Cartwright, RA; Hartley, AL; Hopton, PA; Johnston, HE; Mann, JR; McKinney, PA; Stiller, CA; Waterhouse, JA, 1985) |
| "Whether the severity of vitamin B6 deficiency would precipitate clinical signs like oral lesions is not yet known." | 1.26 | Biochemical assessment of vitamin B6 nutritional status in pregnant women with orolingual manifestations. ( Bapurao, S; Raman, L; Tulpule, PG, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 108 (65.45) | 18.7374 |
| 1990's | 19 (11.52) | 18.2507 |
| 2000's | 19 (11.52) | 29.6817 |
| 2010's | 14 (8.48) | 24.3611 |
| 2020's | 5 (3.03) | 2.80 |
| Authors | Studies |
|---|---|
| Schrager, NL | 1 |
| Parker, SE | 1 |
| Werler, MM | 1 |
| Jayawardena, R | 1 |
| Majeed, S | 1 |
| Sooriyaarachchi, P | 1 |
| Abeywarne, U | 1 |
| Ranaweera, P | 1 |
| Saz-Leal, P | 1 |
| Zamorano-Domínguez, L | 1 |
| Frías, J | 1 |
| Guerra, P | 1 |
| Saura-Valls, M | 1 |
| Roca-Juanes, R | 1 |
| Nebot-Troyano, J | 1 |
| García-Aguilar, E | 1 |
| Vilchez, T | 1 |
| Urso, K | 1 |
| Wu, XK | 1 |
| Gao, JS | 1 |
| Ma, HL | 1 |
| Wang, Y | 1 |
| Zhang, B | 1 |
| Liu, ZL | 1 |
| Li, J | 1 |
| Cong, J | 1 |
| Qin, HC | 1 |
| Yang, XM | 1 |
| Wu, Q | 1 |
| Chen, XY | 1 |
| Lu, ZL | 1 |
| Feng, YH | 1 |
| Qi, X | 1 |
| Wang, YX | 1 |
| Yu, L | 1 |
| Cui, YM | 1 |
| An, CM | 1 |
| Zhou, LL | 1 |
| Hu, YH | 1 |
| Li, L | 1 |
| Cao, YJ | 1 |
| Yan, Y | 1 |
| Liu, L | 1 |
| Liu, YX | 1 |
| Liu, ZS | 1 |
| Painter, RC | 1 |
| Ng, EHY | 1 |
| Liu, JP | 1 |
| Mol, BWJ | 1 |
| Wang, CC | 1 |
| Pecriaux, C | 1 |
| Ashkenazi-Hoffnung, L | 1 |
| Merlob, P | 1 |
| Stahl, B | 1 |
| Klinger, G | 1 |
| Niebyl, JR | 2 |
| Briggs, GG | 1 |
| Madjunkova, S | 1 |
| Maltepe, C | 3 |
| Koren, G | 14 |
| Clark, S | 3 |
| Hankins, GD | 3 |
| Caritis, SN | 2 |
| Umans, JG | 3 |
| Miodovnik, M | 3 |
| Mattison, DR | 2 |
| Matok, I | 2 |
| Faramarzi, M | 1 |
| Yazdani, S | 1 |
| Barat, S | 1 |
| McParlin, C | 1 |
| O'Donnell, A | 1 |
| Robson, SC | 1 |
| Beyer, F | 1 |
| Moloney, E | 1 |
| Bryant, A | 1 |
| Bradley, J | 1 |
| Muirhead, CR | 1 |
| Nelson-Piercy, C | 1 |
| Newbury-Birch, D | 1 |
| Norman, J | 1 |
| Shaw, C | 1 |
| Simpson, E | 1 |
| Swallow, B | 1 |
| Yates, L | 1 |
| Vale, L | 1 |
| Zhang, R | 1 |
| Persaud, N | 1 |
| Nulman, I | 1 |
| Rovet, J | 1 |
| Barrera, M | 1 |
| Knittel-Keren, D | 1 |
| Feldman, BM | 1 |
| Kittisupamongkol, W | 1 |
| DIXON, J | 1 |
| ROGANTI, A | 1 |
| CUNEO, JC | 1 |
| HESSELTINE, HC | 1 |
| Gill, SK | 1 |
| Garcia-Bournissen, F | 2 |
| Tan, PC | 1 |
| Omar, SZ | 1 |
| Costantine, MM | 1 |
| Chiossi, G | 1 |
| Caritis, S | 1 |
| Arsenault, MY | 1 |
| Lane, CA | 1 |
| MacKinnon, CJ | 1 |
| Bartellas, E | 1 |
| Cargill, YM | 1 |
| Klein, MC | 1 |
| Martel, MJ | 1 |
| Sprague, AE | 1 |
| Wilson, AK | 1 |
| Tiran, D | 1 |
| Brent, R | 2 |
| Kutcher, JS | 1 |
| Engle, A | 1 |
| Firth, J | 1 |
| Lamm, SH | 1 |
| ZARTMAN, ER | 1 |
| BARNES, AC | 1 |
| HICKS, DJ | 1 |
| BALESTRI, F | 1 |
| NULSEN, RO | 1 |
| MONIAS, M | 1 |
| SHLIAKHTINA, ON | 1 |
| FOSNAUGH, RP | 1 |
| BRYAN, HG | 1 |
| ORDERS, RL | 1 |
| DAVIDSON, OL | 1 |
| GEIGER, CJ | 1 |
| FAHRENBACH, DM | 1 |
| HEALEY, FJ | 1 |
| ALEXANDER, CH | 1 |
| Hillman, RW | 1 |
| Cabaud, PG | 1 |
| Schenone, RA | 1 |
| BARWELL, TE | 1 |
| PATRINI, G | 1 |
| EL-HEFNAWI, H | 1 |
| EL-KOMY, HM | 1 |
| IBRAHIM, AA | 1 |
| RASHEED, A | 1 |
| OUPE, RL | 1 |
| COLOMBINO, C | 1 |
| Boskovic, R | 1 |
| Einarson, A | 2 |
| Wolpin, J | 1 |
| Bsat, FA | 1 |
| Hoffman, DE | 1 |
| Seubert, DE | 1 |
| DORSEY, CW | 1 |
| MULLA, NP | 1 |
| Vilaseca, MA | 1 |
| Cuartero, ML | 1 |
| Martinez de Salinas, M | 1 |
| Lambruschini, N | 1 |
| Pintó, X | 1 |
| Urreizti, R | 1 |
| Balcells, S | 1 |
| Grinberg, D | 1 |
| Sohrabvand, F | 1 |
| Shariat, M | 1 |
| Haghollahi, F | 1 |
| Pierre, G | 1 |
| Gissen, P | 1 |
| Chakrapani, A | 1 |
| McDonald, A | 1 |
| Preece, M | 1 |
| Wright, J | 1 |
| Staroselsky, A | 1 |
| Bejsovec, M | 1 |
| Kulenda, Z | 1 |
| Ponca, E | 1 |
| DiPalma, JR | 1 |
| Vorhees, CV | 1 |
| Butcher, RE | 1 |
| Berry, HK | 1 |
| Aselton, P | 1 |
| Jick, H | 1 |
| Chentow, SJ | 1 |
| Perera, DR | 1 |
| Hunter, JR | 1 |
| Rothman, KJ | 1 |
| Hays, DP | 1 |
| McCredie, J | 1 |
| Kricker, A | 1 |
| Elliott, J | 1 |
| Forrest, J | 1 |
| Davis, JM | 1 |
| Wasynczuk, A | 1 |
| Kirksey, A | 9 |
| Morré, DM | 3 |
| Bermond, P | 1 |
| Huff, PS | 1 |
| Smith, RJ | 1 |
| Burkhart, CG | 1 |
| David, TJ | 1 |
| Bapurao, S | 1 |
| Raman, L | 1 |
| Tulpule, PG | 1 |
| Atkins, JN | 1 |
| Donaldson, GL | 1 |
| Bury, RG | 1 |
| Harron, DW | 1 |
| Griffiths, K | 1 |
| Shanks, RG | 1 |
| Atisook, R | 1 |
| Benjapibal, M | 1 |
| Sunsaneevithayakul, P | 1 |
| Roongpisuthipong, A | 1 |
| Vutyavanich, T | 1 |
| Wongtra-ngan, S | 1 |
| Ruangsri, R | 1 |
| Erick, M | 1 |
| Hamilton, OA | 1 |
| Philpot, J | 1 |
| Muntoni, F | 1 |
| Skellett, S | 1 |
| Dubowitz, V | 1 |
| Vendittelli, F | 1 |
| Alain, J | 1 |
| Nouaille, Y | 1 |
| Brosset, A | 1 |
| Tabaste, JL | 1 |
| Avşar, AF | 1 |
| Ozmen, S | 1 |
| Söylemez, F | 1 |
| Favier, M | 1 |
| Hininger, I | 1 |
| Pastuszak, A | 1 |
| Ito, S | 1 |
| Walter, JH | 1 |
| Wraith, JE | 1 |
| White, FJ | 1 |
| Bridge, C | 1 |
| Till, J | 1 |
| Boneva, RS | 1 |
| Moore, CA | 1 |
| Botto, L | 1 |
| Wong, LY | 1 |
| Erickson, JD | 1 |
| Czeizel, E | 1 |
| Johnson, WG | 1 |
| Emelianova, S | 1 |
| Mazzotta, P | 3 |
| Navioz, Y | 2 |
| Magee, LA | 2 |
| Bishai, R | 1 |
| Atanackovic, G | 2 |
| Levichek, Z | 1 |
| Pole, M | 1 |
| Moretti, ME | 1 |
| Allen, R | 1 |
| Levene, CI | 1 |
| Murray, JC | 1 |
| Pitkin, RM | 3 |
| Wheatley, D | 1 |
| Lambert, D | 1 |
| Laurent, R | 1 |
| Ferry, D | 1 |
| Feldman, D | 1 |
| Chapuis, JL | 1 |
| Agache, P | 1 |
| Kiyan, S | 1 |
| Ahat, E | 1 |
| Tolon, J | 1 |
| Susten, SS | 1 |
| Alton-Mackey, MG | 2 |
| Walker, BL | 2 |
| Smithells, RW | 1 |
| Sheppard, S | 1 |
| Das, GD | 2 |
| Pulkkinen, MO | 1 |
| Salminen, J | 1 |
| Virtanen, S | 1 |
| Reinken, L | 2 |
| Dapunt, O | 3 |
| Verma, KC | 1 |
| Chaudhry, SD | 1 |
| Brenton, DP | 1 |
| Cusworth, DC | 1 |
| Biddle, SA | 1 |
| Garrod, PJ | 1 |
| Lasley, L | 1 |
| Thomas, MR | 2 |
| Lumeng, L | 1 |
| Cleary, RE | 1 |
| Wagner, R | 1 |
| Pang, RL | 2 |
| Lin, WJ | 1 |
| Shane, B | 1 |
| Contractor, SF | 1 |
| Riva, G | 1 |
| Uboldi, L | 1 |
| Bamji, MS | 1 |
| Minkhorst, AG | 1 |
| van Dongen, PW | 1 |
| Boers, GH | 2 |
| de Wit, PH | 1 |
| Guilarte, TR | 1 |
| Miceli, RC | 1 |
| Moran, TH | 1 |
| Sahakian, V | 1 |
| Rouse, D | 1 |
| Sipes, S | 1 |
| Rose, N | 1 |
| Niebyl, J | 1 |
| Giuffrè, R | 1 |
| Liccardo, G | 1 |
| Pastore, FS | 1 |
| Spallone, A | 1 |
| Vagnozzi, R | 1 |
| Skolnick, A | 1 |
| Leathem, AM | 1 |
| Martner-Hewes, PM | 1 |
| Hunt, IF | 1 |
| Murphy, NJ | 1 |
| Swendseid, ME | 1 |
| Settlage, RH | 1 |
| Jick, SS | 1 |
| Garrison, JM | 1 |
| Jedd, MB | 1 |
| Melton, LJ | 1 |
| Griffin, MR | 1 |
| Kaufman, B | 1 |
| Hoffman, AD | 1 |
| Broughton, D | 1 |
| O'Brien, PC | 1 |
| Costa, C | 1 |
| Posternak, FR | 1 |
| Groziak, SM | 1 |
| Ellis, JM | 1 |
| Walters, WA | 1 |
| Mudd, SH | 1 |
| Skovby, F | 1 |
| Levy, HL | 1 |
| Pettigrew, KD | 1 |
| Wilcken, B | 1 |
| Pyeritz, RE | 1 |
| Andria, G | 1 |
| Bromberg, IL | 1 |
| Cerone, R | 1 |
| Schuster, K | 1 |
| Bailey, LB | 1 |
| Dimperio, D | 1 |
| Mahan, CS | 1 |
| Crisafi, B | 1 |
| Bartlett, M | 1 |
| Elbourne, D | 1 |
| Mutch, L | 1 |
| Dauncey, M | 1 |
| Campbell, H | 1 |
| Samphier, M | 1 |
| McKinney, PA | 1 |
| Cartwright, RA | 1 |
| Stiller, CA | 1 |
| Hopton, PA | 1 |
| Mann, JR | 1 |
| Birch, JM | 1 |
| Hartley, AL | 1 |
| Waterhouse, JA | 1 |
| Johnston, HE | 1 |
| Hodges, RE | 1 |
| Iyengar, L | 1 |
| Texier, L | 1 |
| Gauthier, Y | 1 |
| Gauthier, O | 1 |
| Tamisier, JM | 1 |
| Unanue, J | 1 |
| DiLorenzo, PA | 1 |
| Ganich, MM | 2 |
| Berger, H | 1 |
| Körner, WF | 2 |
| Bushkell, LL | 1 |
| Jordon, RE | 1 |
| Goltz, RW | 1 |
| Miller, TJ | 1 |
| Mahmoud, F | 1 |
| De Silva, K | 1 |
| Rimbaud, P | 1 |
| Meynadier, J | 1 |
| Guilhou, JJ | 1 |
| Bouéry, A | 1 |
| Driskell, JA | 2 |
| Strickland, LA | 1 |
| Poon, CH | 1 |
| Foshee, DP | 2 |
| Ritchie, JW | 1 |
| Carson, NA | 1 |
| Heller, S | 1 |
| Salkeld, RM | 1 |
| Karlin, R | 2 |
| Croizat, P | 1 |
| Revol, L | 1 |
| Pommatau, E | 1 |
| Viala, JJ | 1 |
| Dumont, M | 1 |
| McGuinness, BW | 1 |
| Binns, DT | 1 |
| György, P | 1 |
| Krishnaswamy, K | 2 |
| Davis, SD | 1 |
| Nelson, T | 1 |
| Shepard, TH | 1 |
| Brin, M | 1 |
| Pacilli, L | 1 |
| D'Avossa, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prevalence and Burden of Nausea and Vomiting in Pregnant Women in Switzerland: Survey Purity 2022[NCT06055192] | 200 participants (Anticipated) | Observational | 2023-09-30 | Not yet recruiting | |||
| A Double-Blind, Multicenter, Randomized, Placebo-Controlled Trial Of The Efficacy Of Diclectin® For Nausea And Vomiting Of Pregnancy[NCT00614445] | Phase 3 | 280 participants (Actual) | Interventional | 2008-01-31 | Completed | ||
| The Effect of Adjuvant Hypnosis Added to Conventional Therapy on Nausea and Vomiting in Hyperemesis Gravidarum: A Prospective Randomized Study[NCT04828967] | 41 participants (Actual) | Interventional | 2017-01-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The objective of this double-blind, randomized, placebo-controlled study was to assess the efficacy, safety, and tolerability of oral Diclectin® in the treatment of nausea and vomiting of pregnancy (NVP) as measured by the Pregnancy Unique-Quantification of Emesis (PUQE) overall score of symptoms from baseline (Day 1) to end of study visit (Day 15). The PUQE score measured hours of nausea, number of times vomiting, and number of times retching for a TOTAL overall score of symptoms on a scale rated from 3 (no symptoms) to 15 (most severe). (NCT00614445)
Timeframe: Baseline (Day 1) to End of Study Visit Day 15 (± 1 day)
| Intervention | PUQE Score (Mean) |
|---|---|
| Diclectin® | -4.8 |
| Placebo | -3.9 |
22 reviews available for pyridoxine and Complications, Pregnancy
| Article | Year |
|---|---|
The effects of pyridoxine (vitamin B6) supplementation in nausea and vomiting during pregnancy: a systematic review and meta-analysis.
Topics: Antiemetics; Dietary Supplements; Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyrido | 2023 |
Doxylamine/pyridoxine for nausea and vomiting in pregnancy.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Practice Guidelines | 2019 |
The pharmacologic management of nausea and vomiting of pregnancy.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Histamine H1 Antagonists; Humans; N | 2014 |
The delayed-release combination of doxylamine and pyridoxine (Diclegis®/Diclectin ®) for the treatment of nausea and vomiting of pregnancy.
Topics: Antiemetics; Delayed-Action Preparations; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 2014 |
Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review.
Topics: Acupuncture; Adrenal Cortex Hormones; Antiemetics; Doxylamine; Female; Histamine Antagonists; Humans | 2016 |
Clinical practice. Nausea and vomiting in pregnancy.
Topics: Adult; Chorionic Gonadotropin; Complementary Therapies; Diagnosis, Differential; Dicyclomine; Doxyla | 2010 |
Contemporary approaches to hyperemesis during pregnancy.
Topics: Adrenal Cortex Hormones; Antiemetics; Diet; Doxylamine; Female; Humans; Hyperemesis Gravidarum; Obst | 2011 |
Nausea and vomiting in pregnancy: safety and efficacy of self-administered complementary therapies.
Topics: Acupressure; Acupuncture Therapy; Attitude to Health; Complementary Therapies; Female; Humans; Mater | 2002 |
Progress in experimental phenylketonuria: a critical review.
Topics: Abnormalities, Multiple; Animals; Disease Models, Animal; Energy Metabolism; Female; Fenclonine; Glu | 1981 |
Safety of drug therapy for nausea and vomiting of pregnancy.
Topics: Abnormalities, Drug-Induced; Antiemetics; Child; Dicyclomine; Doxylamine; Drug Combinations; Female; | 1980 |
[Vitamins : B1, B6, B12. Consequences of a deficiency, of excessive vitamins and value of systematic supplementation].
Topics: Dietary Supplements; Female; Humans; Nutritional Requirements; Pregnancy; Pregnancy Complications; P | 1997 |
Drugs in pregnancy.
Topics: Abnormalities, Drug-Induced; Animals; Counseling; Dicyclomine; Doxylamine; Drug Combinations; Drug E | 1998 |
Critical appraisal of drug therapy for nausea and vomiting of pregnancy: II. Efficacy and safety of diclectin (doxylamine-B6).
Topics: Antiemetics; Doxylamine; Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Ran | 2000 |
Medical, social, and legal implications of treating nausea and vomiting of pregnancy.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 2002 |
Are we failing women? Advice for nausea and vomiting in pregnancy.
Topics: Acupressure; Causality; Female; Humans; Maternal-Child Nursing; Nausea; Nurse Midwives; Nurse's Role | 2001 |
Vitamin B6 deficiency and immune responses.
Topics: Animals; Antibody Formation; Antimetabolites; BCG Vaccine; Cell Count; Female; Fetus; Humans; Immuni | 1976 |
Nutritional influences during pregnancy.
Topics: Ascorbic Acid; Birth Weight; Body Weight; Calcium, Dietary; Dietary Proteins; Energy Metabolism; Fem | 1977 |
Requirement of vitamin B6 during pregnancy.
Topics: Contraceptives, Oral; Female; Fetal Blood; Humans; Mouth Diseases; Nutritional Requirements; Pregnan | 1976 |
Vitamins and minerals in pregnancy.
Topics: Animals; Ascorbic Acid; Calcium, Dietary; Female; Humans; Hypocalcemia; Infant, Newborn; Infant, New | 1975 |
Safety and efficacy of antiemetics used to treat nausea and vomiting in pregnancy.
Topics: Antiemetics; Antipsychotic Agents; Dicyclomine; Diphenhydramine; Doxylamine; Drug Combinations; Fema | 1986 |
Vitamin B 6 deficiency and brain lipids in the suckling rat.
Topics: Animals; Brain; Cholesterol; Female; Glycolipids; Lipid Metabolism; Liver; Myelin Sheath; Phospholip | 1972 |
Developments leading to the metabolic role of vitamin B 6.
Topics: Acrodynia; Adult; Aged; Aging; Amines; Animals; Arteriosclerosis; Aspartate Aminotransferases; Biolo | 1971 |
15 trials available for pyridoxine and Complications, Pregnancy
| Article | Year |
|---|---|
Acupuncture and Doxylamine-Pyridoxine for Nausea and Vomiting in Pregnancy : A Randomized, Controlled, 2
Topics: Acupuncture Therapy; Antiemetics; Child; Doxylamine; Female; Humans; Nausea; Pregnancy; Pregnancy Co | 2023 |
Maternal safety of the delayed-release doxylamine and pyridoxine combination for nausea and vomiting of pregnancy; a randomized placebo controlled trial.
Topics: Adult; Antiemetics; Delayed-Action Preparations; Dicyclomine; Double-Blind Method; Doxylamine; Drug | 2015 |
A RCT of psychotherapy in women with nausea and vomiting of pregnancy.
Topics: Adolescent; Adult; Cognitive Behavioral Therapy; Combined Modality Therapy; Female; Humans; Mindfuln | 2015 |
8-Way Randomized Controlled Trial of Doxylamine, Pyridoxine and Dicyclomine for Nausea and Vomiting during Pregnancy: Restoration of Unpublished Information.
Topics: Cooperative Behavior; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Physicians | 2017 |
Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
Topics: Adult; Delayed-Action Preparations; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Meth | 2010 |
Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
Topics: Adult; Delayed-Action Preparations; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Meth | 2010 |
Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
Topics: Adult; Delayed-Action Preparations; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Meth | 2010 |
Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial.
Topics: Adult; Delayed-Action Preparations; Dicyclomine; Dose-Response Relationship, Drug; Double-Blind Meth | 2010 |
Determinants of adherence to delayed-release doxylamine and pyridoxine in patients with nausea and vomiting of pregnancy.
Topics: Adult; Antiemetics; Cohort Studies; Delayed-Action Preparations; Dicyclomine; Double-Blind Method; D | 2012 |
Comparison of three outpatient regimens in the management of nausea and vomiting in pregnancy.
Topics: Adult; Antiemetics; Drug Therapy, Combination; Female; Humans; Hyperemesis Gravidarum; Metoclopramid | 2003 |
Vitamin B supplementation for leg cramps during pregnancy.
Topics: Aspartic Acid; Calcium Carbonate; Drug Therapy, Combination; Female; Humans; Leg; Muscle Cramp; Preg | 2006 |
Studies support Bendectin safety claim.
Topics: Antiemetics; Clinical Trials as Topic; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; I | 1981 |
Pyridoxine for nausea and vomiting of pregnancy: a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Antiemetics; Double-Blind Method; Female; Humans; Nausea; Placebos; Pregnancy; Pregnancy Comp | 1995 |
Treatment of pregnancy sickness.
Topics: Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Dicyclomine; Double-Blind Method; Doxylamine; | 1977 |
Adequacy of vitamin B6 supplementation during pregnancy: a prospective study.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Clinical Enzyme Tests; Erythrocytes; Female; Feta | 1976 |
Vitamin B6 is effective therapy for nausea and vomiting of pregnancy: a randomized, double-blind placebo-controlled study.
Topics: Adult; Double-Blind Method; Female; Humans; Nausea; Odds Ratio; Pregnancy; Pregnancy Complications; | 1991 |
[Relations between vitamin B6 status of mother and vitamin B6 nutriture of her newborn infant (author's transl)].
Topics: Adult; Aspartate Aminotransferases; Birth Weight; Chromatography, Ion Exchange; Clinical Trials as T | 1973 |
'Debendox' in pregnancy sickness.
Topics: Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Female; Humans; Nausea; Parasympatholytics; P | 1971 |
128 other studies available for pyridoxine and Complications, Pregnancy
| Article | Year |
|---|---|
The association of nausea and vomiting of pregnancy, its treatments, and select birth defects: Findings from the National Birth Defect Prevention Study.
Topics: Cleft Palate; Craniosynostoses; Female; Humans; Microphthalmos; Nausea; Pregnancy; Pregnancy Complic | 2023 |
Bioavailability of Cariban
Topics: Adult; Antiemetics; Biological Availability; Capsules; Delayed-Action Preparations; Doxylamine; Drug | 2023 |
[Interest of vitamin b6 for treatment of nausea and/or vomiting during pregnancy].
Topics: Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Vitamin B 6; Vomiting | 2020 |
Evaluation of the efficacy and safety of bi-daily combination therapy with pyridoxine and doxylamine for nausea and vomiting of pregnancy.
Topics: Administration, Oral; Adult; Antiemetics; Case-Control Studies; Dicyclomine; Dose-Response Relations | 2013 |
Diclegis for nausea and vomiting of pregnancy.
Topics: Antiemetics; Delayed-Action Preparations; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 2013 |
Long-term neurodevelopment of children exposed to maternal nausea and vomiting of pregnancy and diclectin.
Topics: Adult; Antiemetics; Child; Child Development; Child, Preschool; Cohort Studies; Dicyclomine; Doxylam | 2009 |
Pyridoxine in pregnant women receiving antituberculous drugs.
Topics: Antitubercular Agents; Female; Humans; Isoniazid; Nervous System Diseases; Pregnancy; Pregnancy Comp | 2009 |
Pyridoxine hydrochloride (vitamin B) in emesis and hyperemesis gravidica.
Topics: Female; Humans; Pregnancy; Pregnancy Complications; Pyridoxine; Vomiting | 1946 |
FAILURE of pyridoxine therapy in nausea and vomiting of pregnancy.
Topics: Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Vomiting | 1946 |
Pyridoxine failure in nausea and vomiting of pregnancy.
Topics: Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Vomiting | 1946 |
Systemic bioavailability and pharmacokinetics of the doxylamine-pyridoxine delayed-release combination (Diclectin).
Topics: Adult; Antiemetics; Biological Availability; Canada; Delayed-Action Preparations; Dicyclomine; Doxyl | 2011 |
The management of nausea and vomiting of pregnancy.
Topics: Algorithms; Anti-Inflammatory Agents; Antiemetics; Complementary Therapies; Cost of Illness; Decisio | 2002 |
Bendectin and birth defects: hopefully, the final chapter.
Topics: Abnormalities, Drug-Induced; Adult; Adverse Drug Reaction Reporting Systems; Animals; Antiemetics; C | 2003 |
Bendectin and birth defects. II: Ecological analyses.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Adverse Drug Reaction Reporting Systems | 2003 |
Observations on pyridoxine metabolism in pregnancy.
Topics: Female; Humans; Pregnancy; Pregnancy Complications; Pyridoxine; Tryptophan; Vitamin B 6 Deficiency | 1955 |
[Treatment of hyperemesis gravidarum with combined inositol and pyridoxine].
Topics: Female; Humans; Hyperemesis Gravidarum; Inositol; Pregnancy; Pregnancy Complications; Pyridoxine; Vi | 1955 |
Bendectin in the treatment of nausea of pregnancy.
Topics: Dicyclomine; Doxylamine; Drug Combinations; Histamine H1 Antagonists; Muscle Relaxants, Central; Nau | 1957 |
Evaluation of cyclizine with pyridoxine in vomiting of pregnancy.
Topics: Cyclizine; Female; Histamine H1 Antagonists; Pregnancy; Pregnancy Complications; Pyridoxine; Vitamin | 1957 |
[Pyridoxine therapy of vomiting in pregnancy].
Topics: Female; Pregnancy; Pregnancy Complications; Pyridoxine; Vitamin B 6; Vomiting | 1959 |
Pyridoxine in the treatment of herpes gestationis.
Topics: Dermatitis Herpetiformis; Female; Humans; Pemphigoid Gestationis; Pregnancy; Pregnancy Complications | 1961 |
Clinical experience with a combination of trimethobenzamide and pyridoxine in patients with nausea and vomiting of pregnancy.
Topics: Antiemetics; Benzamides; Female; Humans; Hyperemesis Gravidarum; Nausea; Pregnancy; Pregnancy Compli | 1960 |
Bendectin in the treatment of nausea and vomiting in pregnancy.
Topics: Dicyclomine; Doxylamine; Drug Combinations; Histamine H1 Antagonists; Muscle Relaxants, Central; Nau | 1959 |
Control of nausea and vomiting of pregnancy with rimethobenzamide and pyridoxine.
Topics: Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Vitamin B 6; Vomiting | 1962 |
The effects of pyridoxine supplements on the dental caries experience of pregnant women.
Topics: Dental Caries; Dietary Supplements; Female; Humans; Pregnancy; Pregnancy Complications; Pyridoxine; | 1962 |
"Ancoloxin" and foetal abnormalities.
Topics: Congenital Abnormalities; Female; Meclizine; Pregnancy; Pregnancy Complications; Pyridoxine | 1962 |
[NEURITIS AND POLYNEURITIS IN PREGNANCY AND PUERPERIUM].
Topics: Corrinoids; Dexamethasone; Female; Humans; Neuritis; Pathology; Postpartum Period; Pregnancy; Pregna | 1963 |
HERPES GESTATIONIS.
Topics: Communicable Diseases; Dermatitis Herpetiformis; Drug Therapy; Egypt; Female; Humans; Pathology; Pem | 1963 |
HERPES GESTATIONIS.
Topics: Adrenal Cortex Hormones; Drug Therapy; Female; Herpesviridae Infections; Humans; Pemphigoid Gestatio | 1965 |
[Adrenal cortex hormones and pyridoxine in therapy of hyperemesis gravidarum].
Topics: Adrenal Cortex; Adrenal Cortex Hormones; Female; Hyperemesis Gravidarum; Pregnancy; Pregnancy Compli | 1955 |
Diclectin therapy for nausea and vomiting of pregnancy: effects of optimal dosing.
Topics: Adult; Antiemetics; Dose-Response Relationship, Drug; Doxylamine; Drug Combinations; Female; Humans; | 2003 |
The use of pyridoxine and suprarenal cortex combined in the treatment of nausea and vomiting of pregnancy.
Topics: Female; Folic Acid; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Vitamin B Comple | 1949 |
EVALUATION OF TRIMETHOBENZAMIDE WITH PYRIDOXINE IN NAUSEA AND VOMITING OF PREGNANCY.
Topics: Benzamides; Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Vomiting | 1963 |
Two successful pregnancies in pyridoxine-nonresponsive homocystinuria.
Topics: Abortion, Spontaneous; Adult; Anticoagulants; Betaine; Diet, Protein-Restricted; Female; Gastrointes | 2004 |
Successful treatment of pyridoxine-unresponsive homocystinuria with betaine in pregnancy.
Topics: Adult; Betaine; Female; Gastrointestinal Agents; Homocystinuria; Humans; Pregnancy; Pregnancy Compli | 2006 |
American Gastroenterological Association institute medical position statement on the use of gastrointestinal medication in pregnancy.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Gastrointestinal Agents; Gastrointe | 2007 |
Familial intrauterine convulsions in pyridoxine dependency.
Topics: Adult; Aspartate Aminotransferases; Electroencephalography; Erythrocytes; Female; Fetal Diseases; Hu | 1967 |
Drugs for nausea and vomiting of pregnancy.
Topics: Ethanolamines; Female; Histamine H1 Antagonists; Humans; Nausea; Phenothiazines; Pregnancy; Pregnanc | 1983 |
Pyloric stenosis and maternal Bendectin exposure.
Topics: Adult; Dicyclomine; Doxylamine; Drug Combinations; Drug Prescriptions; Female; Follow-Up Studies; Hu | 1984 |
Debendox and pregnancy.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Pre | 1984 |
Nausea and vomiting of pregnancy.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Pregnancy; Pregnanc | 1983 |
Bendectin: a case of mourning sickness.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Pregnancy; Pregnanc | 1983 |
The innocent bystander. Doxylamine/dicyclomine/pyridoxine and congenital limb defects.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Dose-Response Relationship, Drug; Doxylamine; | 1984 |
Good-bye, Bendectin, old friend.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Drug Industry; Female; Huma | 1984 |
Effect of maternal vitamin B-6 deficiency on specific regions of developing rat brain: amino acid metabolism.
Topics: Amino Acids; Animals; Body Weight; Brain; Diet; Female; Models, Biological; Organ Size; Pregnancy; P | 1983 |
Therapy of side effects of oral contraceptive agents with vitamin B6.
Topics: Contraceptives, Oral; Contraceptives, Oral, Hormonal; Depressive Disorder; Dose-Response Relationshi | 1982 |
Pyridoxine-responsive herpes gestationis.
Topics: Adult; Female; Humans; Pemphigoid Gestationis; Pregnancy; Pregnancy Complications; Pyridoxine; Skin | 1982 |
Debendox does not cause the Poland anomaly.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Antiemetics; Dicyclomine; Doxylamine; Drug Com | 1982 |
Biochemical assessment of vitamin B6 nutritional status in pregnant women with orolingual manifestations.
Topics: Adult; Female; Humans; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Third; Pyridoxic Aci | 1982 |
Maternal plasma concentration of pyridoxal phosphate during pregnancy: adequacy of vitamin B6 supplementation during isoniazid therapy.
Topics: Female; Humans; Isoniazid; Pregnancy; Pregnancy Complications; Pregnancy Complications, Infectious; | 1982 |
Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Female; Fluphenazine; | 1982 |
Indications for bendectin narrowed.
Topics: Antiemetics; Carcinogens; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Pregnancy; Pre | 1981 |
Debendox and congenital malformations in Northern Ireland.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug | 1980 |
Carpal tunnel syndrome during pregnancy: prevalence and blood level of pyridoxine.
Topics: Adult; Carpal Tunnel Syndrome; Cross-Sectional Studies; Female; Humans; Pregnancy; Pregnancy Complic | 1995 |
Vitamin B-6 and ginger in morning sickness.
Topics: Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Pyridoxine; Spices; Vomiting | 1995 |
Gallstones in pregnancy.
Topics: Cholelithiasis; Drug Therapy, Combination; Female; Humans; Phosphatidylcholines; Pregnancy; Pregnanc | 1995 |
Congenital symmetrical weakness of the upper limbs resembling brachial plexus palsy: a possible sequel of drug toxicity in first trimester of pregnancy?
Topics: Age of Onset; Antiemetics; Arm; Dermatoglyphics; Diagnosis, Differential; Dicyclomine; Doxylamine; D | 1995 |
A case of lipomeningocele reported with fluoxetine (and alprazolam, vitamins B1 and B6, heptaminol) prescribed during pregnancy.
Topics: Adult; Alprazolam; Depression; Drug Therapy, Combination; Female; Fluoxetine; Heptaminol; Humans; In | 1995 |
Vitamin B1 and B6 substitution in pregnancy for leg cramps.
Topics: Female; Humans; Leg; Muscle Cramp; Pregnancy; Pregnancy Complications; Pyridoxine; Thiamine | 1996 |
Strategies for the treatment of cystathionine beta-synthase deficiency: the experience of the Willink Biochemical Genetics Unit over the past 30 years.
Topics: Adolescent; Adult; Betaine; Child; Child, Preschool; Cystathionine beta-Synthase; Dose-Response Rela | 1998 |
Nausea during pregnancy and congenital heart defects: a population-based case-control study.
Topics: Adolescent; Adult; Antiemetics; Case-Control Studies; Female; Georgia; Heart Defects, Congenital; Hu | 1999 |
[Primary prevention of developmental abnormalities].
Topics: Abortion, Induced; Anencephaly; Congenital Abnormalities; Female; Folic Acid; Humans; Infant, Newbor | 1999 |
DNA polymorphism-diet-cofactor-development hypothesis and the gene-teratogen model for schizophrenia and other developmental disorders.
Topics: Alleles; Brain; Diet; Female; Folic Acid; Folic Acid Deficiency; Genetic Linkage; Genotype; Humans; | 1999 |
Prevalence and severity of nausea and vomiting of pregnancy and effect of vitamin supplementation.
Topics: Canada; Dietary Supplements; Female; Humans; Nausea; Pregnancy; Pregnancy Complications; Prevalence; | 1999 |
Managing women with nausea and vomiting of pregnancy. Canadian consensus.
Topics: Adult; Anti-Inflammatory Agents; Antiemetics; Asthma; Diagnosis, Differential; Doxylamine; Drug Ther | 2000 |
Attitudes, management and consequences of nausea and vomiting of pregnancy in the United States and Canada.
Topics: Adult; Antiemetics; Attitude; Attitude of Health Personnel; Canada; Cost of Illness; Dicyclomine; Di | 2000 |
Appraisal of drug therapy for nausea and vomiting of pregnancy: I. The placebo effect - methodological and practical considerations.
Topics: Female; Humans; Nausea; Placebo Effect; Pregnancy; Pregnancy Complications; Pyridoxine; Randomized C | 2000 |
The safety of higher than standard dose of doxylamine-pyridoxine (Diclectin) for nausea and vomiting of pregnancy.
Topics: Antiemetics; Doxylamine; Drug Combinations; Female; Humans; Infant, Newborn; Nausea; Pregnancy; Preg | 2001 |
The aetiological role of maternal vitamin-B6 deficiency in the development of atherosclerosis.
Topics: Arteriosclerosis; Blood Vessels; Collagen; Elastin; Female; Humans; Infant, Newborn; Pregnancy; Preg | 1977 |
[Herpes gestationis. Ultrastructural and immunologic data, about two cases (author's transl)].
Topics: Diagnosis, Differential; Female; Humans; Pemphigoid Gestationis; Pemphigus; Pregnancy; Pregnancy Com | 1978 |
[Ptyalismus gravidarum].
Topics: Adult; Dimenhydrinate; Drug Therapy, Combination; Female; Humans; Pregnancy; Pregnancy Complications | 1979 |
Influence of dietary pyridoxine on lactation in the rat.
Topics: Aminoisobutyric Acids; Animals; Female; Growth Hormone; Lactation; Mammary Glands, Animal; Milk; Pre | 1978 |
Physical and neuromotor development of progeny of pyridoxine-restricted rats cross-fostered with control or isonutritional dams.
Topics: Animals; Female; Lactation; Motor Skills; Musculoskeletal Development; Nervous System; Pregnancy; Pr | 1978 |
Teratogenicity testing in humans: a method demonstrating safety of bendectin.
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylam | 1978 |
Effects of vitamin B-6 deficiency on the developing central nervous system of the rat. Gross measurements and cytoarchitectural alterations.
Topics: Animals; Body Weight; Brain; Cell Count; Female; Lactation; Pregnancy; Pregnancy Complications; Purk | 1978 |
Effects of vitamin B-6 deficiency on the developing central nervous system of the rat. Myelination.
Topics: Animals; Axons; Female; Lactation; Nerve Fibers, Myelinated; Pregnancy; Pregnancy Complications; Pyr | 1978 |
Serum vitamin B6 in pure pregnancy depression.
Topics: Adult; Depression; Female; Humans; Pregnancy; Pregnancy Complications; Psychological Tests; Pyridoxi | 1978 |
Vitamin B6 nutriture during pregnancy.
Topics: Birth Weight; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pregnancy; Pregnancy Complic | 1978 |
Herpes gestationis ( a case report ).
Topics: Adult; Female; Humans; Pemphigoid Gestationis; Prednisolone; Pregnancy; Pregnancy Complications; Pyr | 1976 |
Pregnancy and homocystinuria.
Topics: Amino Acids; Female; Homocystinuria; Humans; Pedigree; Pregnancy; Pregnancy Complications; Pyridoxin | 1977 |
Congenital deformities associated with Bendectin.
Topics: Abnormalities, Drug-Induced; Adult; Cleft Lip; Cleft Palate; Cyclohexanecarboxylic Acids; Dicyclomin | 1977 |
Nutritional support in obstetrics and gynecology.
Topics: Animals; Blood Volume; Body Weight; Calcium; Contraceptives, Oral; Deficiency Diseases; Dietary Prot | 1976 |
Postnatal patterns of brain lipids in progeny of vitamin B-6 deficient rats before and after pyridoxine supplementation.
Topics: Age Factors; Animals; Body Weight; Brain; Cerebellum; Cerebrosides; Cholesterol; Female; Ganglioside | 1976 |
Postnatal patterns of fatty acids in brain of progeny from vitamin B-6 deficient rats before and after pyridoxine supplementation.
Topics: Age Factors; Animals; Brain; Cerebellum; Fatty Acids; Fatty Acids, Unsaturated; Female; Lactation; P | 1976 |
Effects of different levels of pyridoxine fed during pregnancy superimposed upon growth in the rat.
Topics: Age Factors; Alanine Transaminase; Animal Nutritional Physiological Phenomena; Animals; Body Weight; | 1975 |
Assessment of vitamin B 6 status. Studies on pregnant women and oral contraceptive users.
Topics: Adolescent; Adult; Aspartate Aminotransferases; Clinical Enzyme Tests; Contraceptives, Oral; Enzyme | 1975 |
[Toxicity of 3 antibiotics (amoxicillin, cephalexin, methacyclin) in pregnancy in experimental animals subjected to mild pyridoxine deficiency].
Topics: Animals; Anti-Bacterial Agents; Blood; Body Weight; Female; Fetus; Liver; Pregnancy; Pregnancy Compl | 1975 |
Enzymic evaluation of thiamin, riboflavin and pyridoxine status of parturient women and their newborn infants.
Topics: Aspartate Aminotransferases; Erythrocytes; Female; Fetal Blood; Glutathione Reductase; Humans; India | 1976 |
Cerebral infarction after caesarean section due to heterozygosity for homocystinuria; a case report.
Topics: Adult; Cerebral Infarction; Cesarean Section; Female; Heterozygote; Homocystinuria; Humans; Pregnanc | 1991 |
Developmental effects of vitamin B-6 restriction on the locomotor behavior of rats.
Topics: Aging; Animals; Circadian Rhythm; Female; Lactation; Male; Maternal-Fetal Exchange; Motor Activity; | 1991 |
Potential risk factors for brain tumors in children. An analysis of 200 cases.
Topics: Adolescent; Brain Neoplasms; Child; Dicyclomine; Doxylamine; Drug Combinations; Female; Glioma; Huma | 1990 |
Key witness against morning sickness drug faces scientific fraud charges.
Topics: Animals; Antiemetics; Australia; Biomedical Research; Dicyclomine; Doxylamine; Drug Combinations; Fe | 1990 |
Vitamin B-6 nutriture and plasma diamine oxidase activity in pregnant Hispanic teenagers.
Topics: Adolescent; Alanine Transaminase; Amine Oxidase (Copper-Containing); Female; Hispanic or Latino; Hum | 1986 |
Discontinuation of Bendectin.
Topics: Adult; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Pregnancy; P | 1988 |
Factors associated with infantile hypertrophic pyloric stenosis.
Topics: Birth Order; Breast Feeding; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Hypertrophy | 1988 |
Ritodrine and pyridoxine in herpes gestationis.
Topics: Adult; Female; Humans; Pemphigoid Gestationis; Pregnancy; Pregnancy Complications; Pyridoxine; Ritod | 1986 |
Effects of maternal dietary restriction in vitamin B-6 on neocortex development in rats: B-6 vitamer concentrations, volume and cell estimates.
Topics: Animals; Cell Count; Cerebral Cortex; Female; Lactation; Male; Neurons; Pregnancy; Pregnancy Complic | 1987 |
Treatment of carpal tunnel syndrome with vitamin B6.
Topics: Aspartate Aminotransferases; Carpal Tunnel Syndrome; Electromyography; Female; Humans; Male; Pregnan | 1987 |
The management of nausea and vomiting during pregnancy.
Topics: Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Legislation, Drug; Nausea; | 1987 |
The natural history of homocystinuria due to cystathionine beta-synthase deficiency.
Topics: Adolescent; Adult; Child; Child, Preschool; Clinical Enzyme Tests; Cystathionine beta-Synthase; Fema | 1985 |
Morning sickness and vitamin B6 status of pregnant women.
Topics: Adolescent; Adult; Aspartate Aminotransferases; Erythrocytes; Female; Humans; Nausea; Pregnancy; Pre | 1985 |
Suitable alternatives to Debendox for morning sickness in pregnancy.
Topics: Antiemetics; Female; Histamine Antagonists; Humans; Pregnancy; Pregnancy Complications; Pyridoxine | 1985 |
Debendox revisited.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Drug Com | 1985 |
Inter-Regional Epidemiological Study of Childhood Cancer (IRESCC): childhood cancer and the consumption of debendox and related drugs in pregnancy.
Topics: Adolescent; Antiemetics; Child; Cyclohexanecarboxylic Acids; Dicyclomine; Dose-Response Relationship | 1985 |
Nutrition and "the pill".
Topics: Chlormadinone Acetate; Contraceptives, Oral; Demography; Dimethisterone; Ethynodiol Diacetate; Femal | 1971 |
Oral lesions in pregnancy.
Topics: Female; Glossitis; Humans; India; Oral Manifestations; Pregnancy; Pregnancy Complications; Pyridoxin | 1973 |
[Herpes gestationis].
Topics: Dermatitis Herpetiformis; Female; Histamine H1 Antagonists; Humans; Pregnancy; Pregnancy Complicatio | 1972 |
Pellagra-like syndrome associated with isoniazid therapy.
Topics: Adult; Facial Dermatoses; Female; Hand Dermatoses; Humans; Isoniazid; Nicotinic Acids; Pellagra; Pig | 1967 |
[Dermatological side effects of the so called ovulation inhibitors].
Topics: Adult; Age Factors; Contraceptives, Oral; Drug Eruptions; Female; Humans; Middle Aged; Postpartum Pe | 1971 |
[Vitamins C, PP and B-6 in the blood and placenta in the developmental dynamics of pregnancy and labor normally and in obstetrical pathology].
Topics: Ascorbic Acid; Blood Chemical Analysis; Female; Humans; Labor, Obstetric; Niacinamide; Obstetric Lab | 1973 |
[Vitamins C, PP and B6 in the blood and placenta in the dynamics of the development of pregnancy and labor normally and in obstetrical pathology].
Topics: Ascorbic Acid; Female; Humans; Labor, Obstetric; Niacinamide; Obstetric Labor Complications; Placent | 1973 |
Herpes gestationis. New immunologic findings.
Topics: Adult; Animals; Antibodies; Basement Membrane; Biopsy; Complement System Proteins; Dermatitis Herpet | 1974 |
Cleft palate formation: a role for pyridoxine in the closure of the secondary palate in mice.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Cortisone; Diet; Female; Mice; Palate; Pregnancy | 1972 |
Herpes gestationis.
Topics: Dermatitis Herpetiformis; Female; Fetal Death; Humans; Prednisolone; Pregnancy; Pregnancy Complicati | 1972 |
[Herpes gestationis. Favorable action of vitamin B 6 ].
Topics: Dermatitis Herpetiformis; Female; Humans; Pregnancy; Pregnancy Complications; Pyridoxine | 1972 |
The vitamin B 6 requirement of the male rat as determined by behavioral patterns, brain pyridoxal phosphate and nucleic acid composition and erythrocyte alanine aminotransferase activity.
Topics: Age Factors; Alanine Transaminase; Animals; Behavior, Animal; Brain; DNA; Dose-Response Relationship | 1973 |
Graded levels of pyridoxine in the rat diet during gestation and the physical and neuromotor development of offspring.
Topics: Age Factors; Animal Nutritional Physiological Phenomena; Animals; Behavior, Animal; Birth Weight; Do | 1973 |
Pregnancy and homocystinuria.
Topics: Adult; Amnion; Blood Coagulation Tests; Cell Line; Cystine; Female; Fibroblasts; Folic Acid; Homocys | 1973 |
Vitamin B6 status in pregnancy.
Topics: Abortion, Spontaneous; Adolescent; Adult; Aspartate Aminotransferases; Birth Weight; Diabetes Mellit | 1973 |
Early postnatal changes in brain composition in progeny of rats fed different levels of dietary pyridoxine.
Topics: Animal Nutritional Physiological Phenomena; Animals; Body Weight; Brain; Cerebrosides; Cholesterol; | 1974 |
Behavioral patterns and brain nucleic acid and pyridoxal phosphate contents of male rat progeny from vitamin B-6-repleted dams.
Topics: Animals; Auditory Perception; Behavior, Animal; Brain; DNA; Exploratory Behavior; Female; Gestationa | 1974 |
[Studies on vitamin B6 deficiency during pregnacy and in various pathological states using pyridoxine saturation test].
Topics: Anemia, Hypochromic; Anemia, Macrocytic; Anemia, Pernicious; Bone Marrow Diseases; Diabetes Mellitus | 1968 |
Methionine load test in pyridoxine deficiency.
Topics: Aspartate Aminotransferases; Cystathionine; Cysteine; Erythrocytes; Female; Humans; Hydro-Lyases; Me | 1972 |
Erythrocyte glutamic oxaloacetic transaminase activity in patients with oral lesions.
Topics: Aspartate Aminotransferases; Cheilitis; Erythrocytes; Female; Glossitis; Humans; Male; Metabolism; M | 1971 |
Teratogenicity of vitamin B6 deficiency: omphalocele, skeletal and neural defects, and splenic hypoplasia.
Topics: Animals; Brain; Cleft Palate; Disease Models, Animal; Female; Hernia, Ventral; Limb Deformities, Con | 1970 |
Abnormal tryptophan metabolism in pregnancy and with the oral contraceptive pill. II. Relative levels of vitamin B 6-vitamers in cord and maternal blood.
Topics: Blood; Contraceptives, Oral; Erythrocytes; Female; Humans; Maternal-Fetal Exchange; Pregnancy; Pregn | 1971 |
[On the treatment of hyperemesis gravidarum. Clinical case studies].
Topics: Adult; Female; Humans; Hyperemesis Gravidarum; Pregnancy; Pregnancy Complications; Pyridoxine; Thiam | 1967 |
[Research on avitaminosis B6 with the aid of a pyridoxine loading test].
Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Maternal-Fetal Exchange; Pregnancy | 1968 |
[Research on the direct measurement of vitamin B 6 in the blood of pregnant women].
Topics: Female; Humans; Pregnancy; Pregnancy Complications; Pyridoxine; Vitamin B Deficiency | 1966 |