pyridoxine and Coma
pyridoxine has been researched along with Coma in 24 studies
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " Acute isoniazid intoxication is characterized by a clinical triad consisting of metabolic acidosis resistant to treatment with sodium bicarbonate, seizures which may be fatal and refractory to standard anticonvulsant therapy, and coma." | 7.73 | Seizures, metabolic acidosis and coma resulting from acute isoniazid intoxication. ( Ekici, NZ; Kefi, A; Sakarya, M; Topcu, I; Yentur, EA, 2005) |
| "Pyridoxine has been reported to be effective in treating isoniazid-induced seizures." | 5.28 | Reversal of prolonged isoniazid-induced coma by pyridoxine. ( Brent, J; Kulig, K; Rumack, BH; Vo, N, 1990) |
| " Acute isoniazid intoxication is characterized by a clinical triad consisting of metabolic acidosis resistant to treatment with sodium bicarbonate, seizures which may be fatal and refractory to standard anticonvulsant therapy, and coma." | 3.73 | Seizures, metabolic acidosis and coma resulting from acute isoniazid intoxication. ( Ekici, NZ; Kefi, A; Sakarya, M; Topcu, I; Yentur, EA, 2005) |
| "A 14-yr old previously healthy girl receiving preventive isoniazid therapy who suddenly developed generalized tonic-clonic seizures and coma." | 3.70 | Acute isoniazid neurotoxicity during preventive therapy. ( Gorjup, V; Horvat, M; Martinjak-Dvorsek, I; Noc, M, 2000) |
| "Ethylene glycol toxicity has produced central nervous system abnormalities including coma, cerebral edema, and cranial nerve dysfunction." | 3.70 | Ethylene glycol ingestion resulting in brainstem and midbrain dysfunction. ( Follmer, R; Ford, MD; Morgan, BW, 2000) |
| "Acute isoniazid intoxication is characterised by high mortality and vomiting, seizures, coma and metabolic acidosis as main symptoms." | 3.67 | [Acute isoniazid poisoning]. ( Bode, U; Köster, B; Musch, E; Weber, HP, 1985) |
| "Pyridoxine has been reported to be effective in treating isoniazid-induced seizures." | 1.28 | Reversal of prolonged isoniazid-induced coma by pyridoxine. ( Brent, J; Kulig, K; Rumack, BH; Vo, N, 1990) |
| "We treated five isoniazid-overdosed patients each with a single dose of pyridoxine hydrochloride equivalent to the gram amount of isoniazid ingested and compared their outcome with that of 41 patients from the literature who received little or no pyridoxine." | 1.26 | Single high-dose pyridoxine treatment for isoniazid overdose. ( Lacouture, PG; Lovejoy, FH; Wason, S, 1981) |
Research
Studies (24)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (50.00) | 18.7374 |
| 1990's | 4 (16.67) | 18.2507 |
| 2000's | 6 (25.00) | 29.6817 |
| 2010's | 2 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Uzman, S | 1 |
| Uludağ Yanaral, T | 1 |
| Toptaş, M | 1 |
| Koç, A | 1 |
| Taş, A | 1 |
| Bican, G | 1 |
| Tai, WP | 1 |
| Yue, H | 1 |
| Hu, PJ | 1 |
| Vonghia, L | 1 |
| Leggio, L | 1 |
| Ferrulli, A | 1 |
| Bertini, M | 1 |
| Gasbarrini, G | 1 |
| Addolorato, G | 1 |
| Tabarki, B | 1 |
| Thabet, F | 1 |
| ALPHONSE, P | 1 |
| MARTIN, E | 1 |
| Topcu, I | 1 |
| Yentur, EA | 1 |
| Kefi, A | 1 |
| Ekici, NZ | 1 |
| Sakarya, M | 1 |
| Miller, J | 1 |
| Robinson, A | 1 |
| Percy, AK | 1 |
| Wason, S | 1 |
| Lacouture, PG | 1 |
| Lovejoy, FH | 1 |
| Lahori, UC | 1 |
| Sharma, DB | 1 |
| Marcovigi, P | 1 |
| Valtancoli, E | 1 |
| Calbi, P | 1 |
| Farolfi, P | 1 |
| Calbi, G | 1 |
| Temmerman, W | 1 |
| Dhondt, A | 1 |
| Vandewoude, K | 1 |
| Martinjak-Dvorsek, I | 1 |
| Gorjup, V | 1 |
| Horvat, M | 1 |
| Noc, M | 1 |
| Morgan, BW | 1 |
| Ford, MD | 1 |
| Follmer, R | 1 |
| Grillo, E | 1 |
| da Silva, RJ | 1 |
| Barbato, JH | 1 |
| Martí Viaño, JL | 1 |
| Sellés, J | 1 |
| Orts, A | 1 |
| Marco, J | 1 |
| Vega, F | 1 |
| Esplugues, J | 1 |
| Kirklin, JK | 1 |
| Watson, M | 1 |
| Bondoc, CC | 1 |
| Burke, JF | 1 |
| Sievers, ML | 1 |
| Herrier, RN | 1 |
| de' Clari, F | 1 |
| Brent, J | 1 |
| Vo, N | 1 |
| Kulig, K | 1 |
| Rumack, BH | 1 |
| Köster, B | 1 |
| Bode, U | 1 |
| Weber, HP | 1 |
| Musch, E | 1 |
| Bleandonu, G | 1 |
| Boye, J | 1 |
| Cantero Gómez, F | 1 |
| Friedman, SA | 1 |
| Espagno, J | 1 |
| Arbus, L | 1 |
| Lazorthes, Y | 1 |
| Viallard, G | 1 |
Reviews
2 reviews available for pyridoxine and Coma
| Article | Year |
|---|---|
Acute alcohol intoxication.
Topics: Acute Disease; Alcohol Deterrents; Alcoholic Intoxication; Ataxia; Coma; Diagnosis, Differential; Dr | 2008 |
Acute isoniazid intoxication: seizures, acidosis and coma.
Topics: Acidosis; Acute Disease; Adolescent; Antitubercular Agents; Coma; Diagnosis, Differential; Drug Over | 1999 |
Other Studies
22 other studies available for pyridoxine and Coma
| Article | Year |
|---|---|
Acute isoniazid intoxication: an uncommon cause of convulsion, coma and acidosis.
Topics: Acidosis; Antitubercular Agents; Coma; Humans; Infusions, Intravenous; Isoniazid; Male; Pyridoxine; | 2013 |
Coma caused by isoniazid poisoning in a patient treated with pyridoxine and hemodialysis.
Topics: Adult; Antitubercular Agents; Coma; Humans; Isoniazid; Male; Pyridoxine; Renal Dialysis; Suicide, At | 2008 |
[Prolonged electrocerebral depression after oral administration of pyridoxine for pyridoxine-dependent convulsions].
Topics: Administration, Oral; Aldehyde Dehydrogenase; Anticonvulsants; Brain Death; Chromosome Aberrations; | 2010 |
The renal factor in the pathogenesis of diabetic coma.
Topics: Ascomycota; Coma; Diabetes Mellitus; Humans; Pyridoxine | 1945 |
Seizures, metabolic acidosis and coma resulting from acute isoniazid intoxication.
Topics: Acidosis; Acute Disease; Adolescent; Anticonvulsants; Antitubercular Agents; Charcoal; Child; Coma; | 2005 |
Acute isoniazid poisoning in childhood.
Topics: Adolescent; Child, Preschool; Coma; Female; Humans; Infant; Isoniazid; Male; Paraldehyde; Pyridoxine | 1980 |
Single high-dose pyridoxine treatment for isoniazid overdose.
Topics: Acidosis; Adolescent; Adult; Bicarbonates; Coma; Female; Humans; Isoniazid; Male; Pyridoxine; Seizur | 1981 |
Acute isoniazid poisoning in children.
Topics: Acute Disease; Child, Preschool; Coma; Diazepam; Female; Humans; Isoniazid; Pyridoxine; Seizures | 1981 |
[Pyridoxine administration in acute isoniazid intoxication].
Topics: Acidosis; Blood Gas Analysis; Child, Preschool; Coma; Female; Gastric Lavage; Humans; Isoniazid; Poi | 1993 |
Acute isoniazid neurotoxicity during preventive therapy.
Topics: Acute Disease; Adolescent; Antitubercular Agents; Coma; Conscious Sedation; Electroencephalography; | 2000 |
Ethylene glycol ingestion resulting in brainstem and midbrain dysfunction.
Topics: Acute Kidney Injury; Adult; Arrhythmias, Cardiac; Brain Diseases; Brain Edema; Brain Stem; Calcium G | 2000 |
Pyridoxine-dependent seizures responding to extremely low-dose pyridoxine.
Topics: Age Factors; Body Weight; Coma; Confounding Factors, Epidemiologic; Developmental Disabilities; Drug | 2001 |
[Antagonism of barbituric coma by stimulating products. Experimental study].
Topics: Animals; Body Weight; Choline; Coma; Cytidine Diphosphate Choline; Female; Glycolates; Injections, I | 1978 |
Treatment of hydrazine-induced coma with pyridoxine.
Topics: Accidents, Occupational; Adult; Burns, Chemical; Coma; Humans; Hydrazines; Injections, Intramuscular | 1976 |
Treatment of acute isoniazid toxicity.
Topics: Acidosis; Adolescent; Adult; Airway Obstruction; Anticonvulsants; Bicarbonates; Coma; Diuresis; Fema | 1975 |
The paradoxical anticonvulsive and awakening effect of high-dose pyridoxine treatment for isoniazid intoxication.
Topics: Coma; Humans; Isoniazid; Pyridoxine | 1992 |
Reversal of prolonged isoniazid-induced coma by pyridoxine.
Topics: Adolescent; Adult; Coma; Drug Overdose; Female; Humans; Isoniazid; Male; Pyridoxine | 1990 |
[Acute isoniazid poisoning].
Topics: Acidosis; Coma; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Infant; Isoniazid; Metab | 1985 |
[Neuropsychiatric incidences in antitubercular treatment consisting of isoniazid or isoniazid and ethionamide (8 cases)].
Topics: Acidosis; Adult; Alcoholism; Ammonia; Avitaminosis; Carboxy-Lyases; Chromatography, Paper; Chromatog | 1969 |
[Our experience with conductase in resuscitation].
Topics: Adult; Aged; Coma; Female; Humans; Ketoglutaric Acids; Male; Middle Aged; Pyridoxine; Resuscitation | 1972 |
Death following massive ingestion of isoniazid.
Topics: Acidosis; Adolescent; Anticonvulsants; Coma; Fever; Gastric Lavage; Humans; Intubation, Intratrachea | 1969 |
[Action of pyridoxylate on the arterio-venous differences of O2 and CO2 in the brain].
Topics: Brain Injuries; Carbon Dioxide; Cerebrovascular Disorders; Coma; Glyoxylates; Humans; Hypoxia, Brain | 1970 |