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pyridoxine and Coma

pyridoxine has been researched along with Coma in 24 studies

4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).

Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.

Research Excerpts

ExcerptRelevanceReference
" Acute isoniazid intoxication is characterized by a clinical triad consisting of metabolic acidosis resistant to treatment with sodium bicarbonate, seizures which may be fatal and refractory to standard anticonvulsant therapy, and coma."7.73Seizures, metabolic acidosis and coma resulting from acute isoniazid intoxication. ( Ekici, NZ; Kefi, A; Sakarya, M; Topcu, I; Yentur, EA, 2005)
"Pyridoxine has been reported to be effective in treating isoniazid-induced seizures."5.28Reversal of prolonged isoniazid-induced coma by pyridoxine. ( Brent, J; Kulig, K; Rumack, BH; Vo, N, 1990)
" Acute isoniazid intoxication is characterized by a clinical triad consisting of metabolic acidosis resistant to treatment with sodium bicarbonate, seizures which may be fatal and refractory to standard anticonvulsant therapy, and coma."3.73Seizures, metabolic acidosis and coma resulting from acute isoniazid intoxication. ( Ekici, NZ; Kefi, A; Sakarya, M; Topcu, I; Yentur, EA, 2005)
"A 14-yr old previously healthy girl receiving preventive isoniazid therapy who suddenly developed generalized tonic-clonic seizures and coma."3.70Acute isoniazid neurotoxicity during preventive therapy. ( Gorjup, V; Horvat, M; Martinjak-Dvorsek, I; Noc, M, 2000)
"Ethylene glycol toxicity has produced central nervous system abnormalities including coma, cerebral edema, and cranial nerve dysfunction."3.70Ethylene glycol ingestion resulting in brainstem and midbrain dysfunction. ( Follmer, R; Ford, MD; Morgan, BW, 2000)
"Acute isoniazid intoxication is characterised by high mortality and vomiting, seizures, coma and metabolic acidosis as main symptoms."3.67[Acute isoniazid poisoning]. ( Bode, U; Köster, B; Musch, E; Weber, HP, 1985)
"Pyridoxine has been reported to be effective in treating isoniazid-induced seizures."1.28Reversal of prolonged isoniazid-induced coma by pyridoxine. ( Brent, J; Kulig, K; Rumack, BH; Vo, N, 1990)
"We treated five isoniazid-overdosed patients each with a single dose of pyridoxine hydrochloride equivalent to the gram amount of isoniazid ingested and compared their outcome with that of 41 patients from the literature who received little or no pyridoxine."1.26Single high-dose pyridoxine treatment for isoniazid overdose. ( Lacouture, PG; Lovejoy, FH; Wason, S, 1981)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-199012 (50.00)18.7374
1990's4 (16.67)18.2507
2000's6 (25.00)29.6817
2010's2 (8.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Uzman, S1
Uludağ Yanaral, T1
Toptaş, M1
Koç, A1
Taş, A1
Bican, G1
Tai, WP1
Yue, H1
Hu, PJ1
Vonghia, L1
Leggio, L1
Ferrulli, A1
Bertini, M1
Gasbarrini, G1
Addolorato, G1
Tabarki, B1
Thabet, F1
ALPHONSE, P1
MARTIN, E1
Topcu, I1
Yentur, EA1
Kefi, A1
Ekici, NZ1
Sakarya, M1
Miller, J1
Robinson, A1
Percy, AK1
Wason, S1
Lacouture, PG1
Lovejoy, FH1
Lahori, UC1
Sharma, DB1
Marcovigi, P1
Valtancoli, E1
Calbi, P1
Farolfi, P1
Calbi, G1
Temmerman, W1
Dhondt, A1
Vandewoude, K1
Martinjak-Dvorsek, I1
Gorjup, V1
Horvat, M1
Noc, M1
Morgan, BW1
Ford, MD1
Follmer, R1
Grillo, E1
da Silva, RJ1
Barbato, JH1
Martí Viaño, JL1
Sellés, J1
Orts, A1
Marco, J1
Vega, F1
Esplugues, J1
Kirklin, JK1
Watson, M1
Bondoc, CC1
Burke, JF1
Sievers, ML1
Herrier, RN1
de' Clari, F1
Brent, J1
Vo, N1
Kulig, K1
Rumack, BH1
Köster, B1
Bode, U1
Weber, HP1
Musch, E1
Bleandonu, G1
Boye, J1
Cantero Gómez, F1
Friedman, SA1
Espagno, J1
Arbus, L1
Lazorthes, Y1
Viallard, G1

Reviews

2 reviews available for pyridoxine and Coma

ArticleYear
Acute alcohol intoxication.
    European journal of internal medicine, 2008, Volume: 19, Issue:8

    Topics: Acute Disease; Alcohol Deterrents; Alcoholic Intoxication; Ataxia; Coma; Diagnosis, Differential; Dr

2008
Acute isoniazid intoxication: seizures, acidosis and coma.
    Acta clinica Belgica, 1999, Volume: 54, Issue:4

    Topics: Acidosis; Acute Disease; Adolescent; Antitubercular Agents; Coma; Diagnosis, Differential; Drug Over

1999

Other Studies

22 other studies available for pyridoxine and Coma

ArticleYear
Acute isoniazid intoxication: an uncommon cause of convulsion, coma and acidosis.
    Tuberkuloz ve toraks, 2013, Volume: 61, Issue:1

    Topics: Acidosis; Antitubercular Agents; Coma; Humans; Infusions, Intravenous; Isoniazid; Male; Pyridoxine;

2013
Coma caused by isoniazid poisoning in a patient treated with pyridoxine and hemodialysis.
    Advances in therapy, 2008, Volume: 25, Issue:10

    Topics: Adult; Antitubercular Agents; Coma; Humans; Isoniazid; Male; Pyridoxine; Renal Dialysis; Suicide, At

2008
[Prolonged electrocerebral depression after oral administration of pyridoxine for pyridoxine-dependent convulsions].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2010, Volume: 17, Issue:2

    Topics: Administration, Oral; Aldehyde Dehydrogenase; Anticonvulsants; Brain Death; Chromosome Aberrations;

2010
The renal factor in the pathogenesis of diabetic coma.
    Schweizerische medizinische Wochenschrift, 1945, Mar-24, Volume: 75

    Topics: Ascomycota; Coma; Diabetes Mellitus; Humans; Pyridoxine

1945
Seizures, metabolic acidosis and coma resulting from acute isoniazid intoxication.
    Anaesthesia and intensive care, 2005, Volume: 33, Issue:4

    Topics: Acidosis; Acute Disease; Adolescent; Anticonvulsants; Antitubercular Agents; Charcoal; Child; Coma;

2005
Acute isoniazid poisoning in childhood.
    American journal of diseases of children (1960), 1980, Volume: 134, Issue:3

    Topics: Adolescent; Child, Preschool; Coma; Female; Humans; Infant; Isoniazid; Male; Paraldehyde; Pyridoxine

1980
Single high-dose pyridoxine treatment for isoniazid overdose.
    JAMA, 1981, Sep-04, Volume: 246, Issue:10

    Topics: Acidosis; Adolescent; Adult; Bicarbonates; Coma; Female; Humans; Isoniazid; Male; Pyridoxine; Seizur

1981
Acute isoniazid poisoning in children.
    Indian pediatrics, 1981, Volume: 18, Issue:11

    Topics: Acute Disease; Child, Preschool; Coma; Diazepam; Female; Humans; Isoniazid; Pyridoxine; Seizures

1981
[Pyridoxine administration in acute isoniazid intoxication].
    Minerva pediatrica, 1993, Volume: 45, Issue:9

    Topics: Acidosis; Blood Gas Analysis; Child, Preschool; Coma; Female; Gastric Lavage; Humans; Isoniazid; Poi

1993
Acute isoniazid neurotoxicity during preventive therapy.
    Critical care medicine, 2000, Volume: 28, Issue:2

    Topics: Acute Disease; Adolescent; Antitubercular Agents; Coma; Conscious Sedation; Electroencephalography;

2000
Ethylene glycol ingestion resulting in brainstem and midbrain dysfunction.
    Journal of toxicology. Clinical toxicology, 2000, Volume: 38, Issue:4

    Topics: Acute Kidney Injury; Adult; Arrhythmias, Cardiac; Brain Diseases; Brain Edema; Brain Stem; Calcium G

2000
Pyridoxine-dependent seizures responding to extremely low-dose pyridoxine.
    Developmental medicine and child neurology, 2001, Volume: 43, Issue:6

    Topics: Age Factors; Body Weight; Coma; Confounding Factors, Epidemiologic; Developmental Disabilities; Drug

2001
[Antagonism of barbituric coma by stimulating products. Experimental study].
    Revista espanola de anestesiologia y reanimacion, 1978, Volume: 25, Issue:1

    Topics: Animals; Body Weight; Choline; Coma; Cytidine Diphosphate Choline; Female; Glycolates; Injections, I

1978
Treatment of hydrazine-induced coma with pyridoxine.
    The New England journal of medicine, 1976, Apr-22, Volume: 294, Issue:17

    Topics: Accidents, Occupational; Adult; Burns, Chemical; Coma; Humans; Hydrazines; Injections, Intramuscular

1976
Treatment of acute isoniazid toxicity.
    American journal of hospital pharmacy, 1975, Volume: 32, Issue:2

    Topics: Acidosis; Adolescent; Adult; Airway Obstruction; Anticonvulsants; Bicarbonates; Coma; Diuresis; Fema

1975
The paradoxical anticonvulsive and awakening effect of high-dose pyridoxine treatment for isoniazid intoxication.
    Archives of internal medicine, 1992, Volume: 152, Issue:11

    Topics: Coma; Humans; Isoniazid; Pyridoxine

1992
Reversal of prolonged isoniazid-induced coma by pyridoxine.
    Archives of internal medicine, 1990, Volume: 150, Issue:8

    Topics: Adolescent; Adult; Coma; Drug Overdose; Female; Humans; Isoniazid; Male; Pyridoxine

1990
[Acute isoniazid poisoning].
    Anasthesie, Intensivtherapie, Notfallmedizin, 1985, Volume: 20, Issue:1

    Topics: Acidosis; Coma; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Infant; Isoniazid; Metab

1985
[Neuropsychiatric incidences in antitubercular treatment consisting of isoniazid or isoniazid and ethionamide (8 cases)].
    Annales medico-psychologiques, 1969, Volume: 127, Issue:2

    Topics: Acidosis; Adult; Alcoholism; Ammonia; Avitaminosis; Carboxy-Lyases; Chromatography, Paper; Chromatog

1969
[Our experience with conductase in resuscitation].
    Revista espanola de anestesiologia y reanimacion, 1972, Volume: 19, Issue:4

    Topics: Adult; Aged; Coma; Female; Humans; Ketoglutaric Acids; Male; Middle Aged; Pyridoxine; Resuscitation

1972
Death following massive ingestion of isoniazid.
    The American review of respiratory disease, 1969, Volume: 100, Issue:6

    Topics: Acidosis; Adolescent; Anticonvulsants; Coma; Fever; Gastric Lavage; Humans; Intubation, Intratrachea

1969
[Action of pyridoxylate on the arterio-venous differences of O2 and CO2 in the brain].
    Therapeutique (La Semaine des hopitaux), 1970, Volume: 46, Issue:8

    Topics: Brain Injuries; Carbon Dioxide; Cerebrovascular Disorders; Coma; Glyoxylates; Humans; Hypoxia, Brain

1970