pyridoxine has been researched along with Cleft Palate in 16 studies
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
Cleft Palate: Congenital fissure of the soft and/or hard palate, due to faulty fusion.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The pregnancy was complicated by chronic maternal schizophrenia, severe toxaemia and maternal use of fluphenazine enanthate, dicyclomine hydrochloride, doxylamine succinate, pyridoxine hydrochloride and other drugs." | 7.66 | Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy. ( Bury, RG; Donaldson, GL, 1982) |
| "Administration of Vitamin B6 during gestation to mice on a Vitamin B6-containing diet resulted in a substantial reduction in cortisone-induced cleft palate." | 7.66 | Vitamin B6 reduces cortisone-induced cleft palate in the mouse. ( Pratt, RM; Yoneda, T, 1982) |
| " The pregnancy was complicated by chronic maternal schizophrenia, severe toxaemia and maternal use of fluphenazine enanthate, dicyclomine hydrochloride, doxylamine succinate, pyridoxine hydrochloride and other drugs." | 3.66 | Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy. ( Bury, RG; Donaldson, GL, 1982) |
| "Administration of Vitamin B6 during gestation to mice on a Vitamin B6-containing diet resulted in a substantial reduction in cortisone-induced cleft palate." | 3.66 | Vitamin B6 reduces cortisone-induced cleft palate in the mouse. ( Pratt, RM; Yoneda, T, 1982) |
| "Cranial nerve palsy/paresis was only seen in HFM and thalidomide-induced malformations." | 1.30 | Teratological studies on craniofacial malformations. ( Jacobsson, C, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (62.50) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Schrager, NL | 1 |
| Parker, SE | 1 |
| Werler, MM | 1 |
| Krapels, IP | 1 |
| van Rooij, IA | 1 |
| Ocké, MC | 1 |
| van Cleef, BA | 1 |
| Kuijpers-Jagtman, AM | 2 |
| Steegers-Theunissen, RP | 2 |
| Donaldson, GL | 1 |
| Bury, RG | 1 |
| Yoneda, T | 1 |
| Pratt, RM | 1 |
| Mitchell, AA | 1 |
| Rosenberg, L | 1 |
| Shapiro, S | 1 |
| Slone, D | 1 |
| Jacobsson, C | 2 |
| Granström, G | 1 |
| Wong, WY | 1 |
| Eskes, TK | 1 |
| Spauwen, PH | 1 |
| Steegers, EA | 1 |
| Thomas, CM | 1 |
| Hamel, BC | 1 |
| Blom, HJ | 1 |
| Briggs, RM | 1 |
| Dostal, M | 1 |
| Schubert, J | 2 |
| Elbourne, D | 2 |
| Mutch, L | 2 |
| Dauncey, M | 1 |
| Campbell, H | 1 |
| Samphier, M | 1 |
| Miller, TJ | 1 |
| Davis, SD | 1 |
| Nelson, T | 1 |
| Shepard, TH | 1 |
16 other studies available for pyridoxine and Cleft Palate
| Article | Year |
|---|---|
The association of nausea and vomiting of pregnancy, its treatments, and select birth defects: Findings from the National Birth Defect Prevention Study.
Topics: Cleft Palate; Craniosynostoses; Female; Humans; Microphthalmos; Nausea; Pregnancy; Pregnancy Complic | 2023 |
Maternal dietary B vitamin intake, other than folate, and the association with orofacial cleft in the offspring.
Topics: Adult; Case-Control Studies; Cleft Lip; Cleft Palate; Diet; Energy Intake; Female; Folic Acid; Human | 2004 |
Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Female; Fluphenazine; | 1982 |
Vitamin B6 reduces cortisone-induced cleft palate in the mouse.
Topics: Abnormalities, Drug-Induced; Animals; Cells, Cultured; Cleft Palate; Cortisone; Female; Kinetics; Ma | 1982 |
Birth defects related to bendectin use in pregnancy. I. Oral clefts and cardiac defects.
Topics: Antiemetics; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Drug Combinations; Drug Evaluation; F | 1981 |
Effects of vitamin B6 on beta-aminoproprionitrile-induced palatal cleft formation in the rat.
Topics: Administration, Oral; Aminopropionitrile; Animals; Cleft Palate; Diet; Drug Interactions; Female; Ge | 1997 |
Teratological studies on craniofacial malformations.
Topics: Alkaline Phosphatase; Aminopropionitrile; Amniotic Fluid; Animals; Branchial Region; Cartilage; Clef | 1997 |
Nonsyndromic orofacial clefts: association with maternal hyperhomocysteinemia.
Topics: Adult; Case-Control Studies; Child, Preschool; Cleft Lip; Cleft Palate; Erythrocytes; Fasting; Femal | 1999 |
Vitamin supplementation as a possible factor in the incidence of cleft lip/palate deformities in humans.
Topics: Ascorbic Acid; Calcium; Cleft Lip; Cleft Palate; Female; Folic Acid; Humans; Infant, Newborn; Matern | 1976 |
Congenital deformities associated with Bendectin.
Topics: Abnormalities, Drug-Induced; Adult; Cleft Lip; Cleft Palate; Cyclohexanecarboxylic Acids; Dicyclomin | 1977 |
Further studies on protective effects of vitamins in cyclophosphamide-induced cleft palate.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cleft Palate; Cyclophosphamide; Female; Fetus; Li | 1990 |
[Value of different drugs in the prevention of abnormalities].
Topics: Actihaemyl; Animals; Cleft Palate; Dexamethasone; Mice; Pyridoxine; Thiamine; Vitamin B Complex | 1986 |
Debendox.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Drug Com | 1986 |
Debendox revisited.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Drug Com | 1985 |
Cleft palate formation: a role for pyridoxine in the closure of the secondary palate in mice.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Cortisone; Diet; Female; Mice; Palate; Pregnancy | 1972 |
Teratogenicity of vitamin B6 deficiency: omphalocele, skeletal and neural defects, and splenic hypoplasia.
Topics: Animals; Brain; Cleft Palate; Disease Models, Animal; Female; Hernia, Ventral; Limb Deformities, Con | 1970 |