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pyridoxine and Cataract

pyridoxine has been researched along with Cataract in 14 studies

4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).

Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)

Research Excerpts

ExcerptRelevanceReference
"Pyridoxine-dependent epilepsy (PDE) is a cause of neonatal epileptic encephalopathy not previously known to cause ophthalmic disease."7.79Congenital cataract in a child with pyridoxine-dependent epilepsy. ( Hildebrand, GD; Sandford, V; Yusuf, IH, 2013)
"It has been shown that eyes instillation of pyridoxine hydrochloride low doses during 20 days affects the vision and tonographic characteristics of patients with glaucoma and earlier stage of cataract."7.68[Effect of low doses of emoxipine and pyridoxine hydrochloride on the status of patients with cataract and glaucoma]. ( Burlakova, EB; Ianovskaia, NP; Shtol'ko, VN, 1993)
"We studied the effects on the blood-retina barrier of pyridoxal S phosphate, the biologically active form of vitamin B6 (pyridoxine), in 23 male Long-Evans rats in which hyperglycemia had been induced by means of intraperitoneal injection of streptozocin."7.68Effect of pyridoxine on the blood-retina barrier in experimentally induced hyperglycemia in rats. ( Anis, HH; Bahgat, M; Farahat, HG; Khoobehi, B; Parry, GJ; Peyman, GA, 1991)
"In 43 patients with presenile cataracts an oral tryptophan loading test with 5 g L-tryptophan was performed and the 24-hour urinary excretion of kynurenine and xanthurenic acid was determined."7.68Tryptophan metabolic studies in patients with presenile cataracts. ( Franke, G; Grimm, U; Knapp, A; Mellenthin, R; Seidlitz, G, 1990)
"Gyrate atrophy is a rare autosomal recessive disorder caused by a mutation in the ornithine-δ-amino transferase gene."3.88Unique case of gyrate atrophy with a well-preserved electroretinogram (ERG). ( Black, G; Jasani, KM; Kelly, SP; Parry, NRA, 2018)
"Pyridoxine-dependent epilepsy (PDE) is a cause of neonatal epileptic encephalopathy not previously known to cause ophthalmic disease."3.79Congenital cataract in a child with pyridoxine-dependent epilepsy. ( Hildebrand, GD; Sandford, V; Yusuf, IH, 2013)
"The aim of the study is to screen patients for homocystinuria with and without cataract and analyse for homocystine and methionine."3.70Homocystinuria with congenital/developmental cataract. ( Amirthalakshmi, S; Ramakrishnan, S; Sulochana, KN; Tamilselvi, R; Vasanthi, SB, 2000)
"It has been shown that eyes instillation of pyridoxine hydrochloride low doses during 20 days affects the vision and tonographic characteristics of patients with glaucoma and earlier stage of cataract."3.68[Effect of low doses of emoxipine and pyridoxine hydrochloride on the status of patients with cataract and glaucoma]. ( Burlakova, EB; Ianovskaia, NP; Shtol'ko, VN, 1993)
"We studied the effects on the blood-retina barrier of pyridoxal S phosphate, the biologically active form of vitamin B6 (pyridoxine), in 23 male Long-Evans rats in which hyperglycemia had been induced by means of intraperitoneal injection of streptozocin."3.68Effect of pyridoxine on the blood-retina barrier in experimentally induced hyperglycemia in rats. ( Anis, HH; Bahgat, M; Farahat, HG; Khoobehi, B; Parry, GJ; Peyman, GA, 1991)
"In 43 patients with presenile cataracts an oral tryptophan loading test with 5 g L-tryptophan was performed and the 24-hour urinary excretion of kynurenine and xanthurenic acid was determined."3.68Tryptophan metabolic studies in patients with presenile cataracts. ( Franke, G; Grimm, U; Knapp, A; Mellenthin, R; Seidlitz, G, 1990)
" Additionally, one of our patients responded to high dosage vitamin B6 with a 27% reduction in plasma ornithine."1.26Clinical and biochemical heterogeneity in gyrate atrophy. ( Bron, AJ; Kaiser-Kupfer, MI; Valle, D, 1980)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19908 (57.14)18.7374
1990's3 (21.43)18.2507
2000's1 (7.14)29.6817
2010's2 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jasani, KM1
Parry, NRA1
Black, G1
Kelly, SP1
Yusuf, IH1
Sandford, V1
Hildebrand, GD1
HARLEY, JD1
FARRAR, JF1
Pau, H1
Koch, HR1
Hockwin, O2
Weigelin, E3
Baur, M2
Boutros, G1
Kaiser-Kupfer, MI1
Valle, D1
Bron, AJ1
Ianovskaia, NP1
Shtol'ko, VN1
Burlakova, EB1
Sulochana, KN1
Amirthalakshmi, S1
Vasanthi, SB1
Tamilselvi, R1
Ramakrishnan, S1
Anis, HH1
Bahgat, M1
Peyman, GA1
Farahat, HG1
Parry, GJ1
Khoobehi, B1
Grimm, U1
Knapp, A1
Seidlitz, G1
Franke, G1
Mellenthin, R1
Bartsocas, CS1
Levy, HL1
Crawford, JD1
Thier, SO1

Trials

4 trials available for pyridoxine and Cataract

ArticleYear
[Statistical analysis of conservative cataract therapy based on a controlled clinical study of the effectiveness of Phakan/Phakolen].
    Fortschritte der Ophthalmologie : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 1984, Volume: 81, Issue:4

    Topics: Amino Acids; Ascorbic Acid; Cataract; Clinical Trials as Topic; Drug Combinations; Humans; Inositol;

1984
[Controlled clinical study on the efficacy of Phakan as an anticataract drug].
    Fortschritte der Ophthalmologie : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 1982, Volume: 79, Issue:3

    Topics: Adult; Aged; Amino Acids; Ascorbic Acid; Cataract; Clinical Trials as Topic; Double-Blind Method; Dr

1982
[Supplement to the clinical study on the effectiveness of an anticataract preparation].
    Fortschritte der Ophthalmologie : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 1985, Volume: 82, Issue:3

    Topics: Amino Acids; Ascorbic Acid; Cataract; Clinical Trials as Topic; Densitometry; Drug Combinations; Hum

1985
[Results of clinical studies on drug modification of progressive lens opacities].
    Klinische Monatsblatter fur Augenheilkunde, 1985, Volume: 186, Issue:6

    Topics: Amino Acids; Ascorbic Acid; Cataract; Clinical Trials as Topic; Densitometry; Double-Blind Method; D

1985

Other Studies

10 other studies available for pyridoxine and Cataract

ArticleYear
Unique case of gyrate atrophy with a well-preserved electroretinogram (ERG).
    BMJ case reports, 2018, Feb-05, Volume: 2018

    Topics: Adult; Cataract; Cataract Extraction; Diet, Protein-Restricted; Disease Progression; Electroretinogr

2018
Congenital cataract in a child with pyridoxine-dependent epilepsy.
    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2013, Volume: 17, Issue:3

    Topics: Aldehyde Dehydrogenase; Cataract; Child, Preschool; Disease Progression; Epilepsy; Female; Humans; M

2013
MATERNAL DRUG THERAPY AND CONGENITAL CATARACTS.
    The Medical journal of Australia, 1964, Feb-08, Volume: 1

    Topics: Abnormalities, Drug-Induced; Analgesics; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Antipyreti

1964
[Is there hope for drug therapy of cataracts?].
    Therapeutische Umschau. Revue therapeutique, 1984, Volume: 41, Issue:4

    Topics: Aged; Amino Acids; Ascorbic Acid; Cataract; Drug Combinations; Humans; Inositol; Iodine; Pyridoxine

1984
Clinical and biochemical heterogeneity in gyrate atrophy.
    American journal of ophthalmology, 1980, Volume: 89, Issue:2

    Topics: Adolescent; Adult; Atrophy; Cataract; Child; Choroid; Female; Genes; Humans; Ornithine; Ornithine-Ox

1980
[Effect of low doses of emoxipine and pyridoxine hydrochloride on the status of patients with cataract and glaucoma].
    Biulleten' eksperimental'noi biologii i meditsiny, 1993, Volume: 115, Issue:5

    Topics: Cataract; Dose-Response Relationship, Drug; Eye Color; Glaucoma; Humans; Picolines; Pyridoxine; Visi

1993
Homocystinuria with congenital/developmental cataract.
    Indian journal of pediatrics, 2000, Volume: 67, Issue:10

    Topics: Adult; Cataract; Child; Chromatography, Paper; Female; Homocystine; Homocystinuria; Humans; Male; Ma

2000
Effect of pyridoxine on the blood-retina barrier in experimentally induced hyperglycemia in rats.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1991, Volume: 26, Issue:7

    Topics: Animals; Blood-Retinal Barrier; Cataract; Fluorescein; Fluoresceins; Fluorophotometry; Hyperglycemia

1991
Tryptophan metabolic studies in patients with presenile cataracts.
    Biomedica biochimica acta, 1990, Volume: 49, Issue:7

    Topics: Adolescent; Adult; Cataract; Female; Humans; Kynurenine; Male; Pyridoxine; Tryptophan; Xanthurenates

1990
A defect in intestinal amino acid transport in Lowe's syndrome.
    American journal of diseases of children (1960), 1969, Volume: 117, Issue:1

    Topics: Adult; Arginine; Biopsy; Carbon Isotopes; Cataract; Child, Preschool; Glaucoma; Glycine; Humans; Int

1969