pyridoxine has been researched along with Autism in 22 studies
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Several reports have described salutary effects such as decreased physical aggression and improved social responsiveness being associated with the administration of high doses of pyridoxine and magnesium (HDPM) in open-labeled and controlled studies of patients with autism." | 9.08 | High-dose pyridoxine and magnesium administration in children with autistic disorder: an absence of salutary effects in a double-blind, placebo-controlled study. ( Findling, RL; Huang, J; Maxwell, K; Scotese-Wojtila, L; Wiznitzer, M; Yamashita, T, 1997) |
| "Several reports have described salutary effects such as decreased physical aggression and improved social responsiveness being associated with the administration of high doses of pyridoxine and magnesium (HDPM) in open-labeled and controlled studies of patients with autism." | 5.08 | High-dose pyridoxine and magnesium administration in children with autistic disorder: an absence of salutary effects in a double-blind, placebo-controlled study. ( Findling, RL; Huang, J; Maxwell, K; Scotese-Wojtila, L; Wiznitzer, M; Yamashita, T, 1997) |
| "Fenfluramine (n = 104) was third, with a ratio of 1." | 2.37 | Controversies in the treatment of autistic children: vitamin and drug therapy. ( Rimland, B, 1988) |
| "An 11-year-old male with autism became less responsive and was hospitalized with hepatomegaly and liver dysfunction, as well as severe lactic acidosis." | 1.42 | Vitamin B deficiencies in a critically ill autistic child with a restricted diet. ( Baird, JS; Ravindranath, TM, 2015) |
| "The favourable action of vitamin B6 on autism, reported by anglosaxon authors, was confirmed in 15 of the children." | 1.26 | [Modifications in urinary homovanillic acid after ingestion of vitamin B6; functional study in autistic children (author's transl)]. ( Arlot, JC; Callaway, E; Domenech, J; Garreau, B; Lelord, G; Muh, JP; Sauvage, D, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (63.64) | 18.7374 |
| 1990's | 6 (27.27) | 18.2507 |
| 2000's | 1 (4.55) | 29.6817 |
| 2010's | 1 (4.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baird, JS | 1 |
| Ravindranath, TM | 1 |
| Gualtieri, CT | 1 |
| Golden, RN | 1 |
| Fahs, JJ | 1 |
| Lelord, G | 8 |
| Muh, JP | 3 |
| Barthelemy, C | 6 |
| Martineau, J | 6 |
| Garreau, B | 5 |
| Callaway, E | 5 |
| Tolbert, L | 1 |
| Haigler, T | 1 |
| Waits, MM | 1 |
| Dennis, T | 1 |
| Pfeiffer, SI | 1 |
| Norton, J | 1 |
| Nelson, L | 1 |
| Shott, S | 1 |
| Findling, RL | 1 |
| Maxwell, K | 1 |
| Scotese-Wojtila, L | 1 |
| Huang, J | 1 |
| Yamashita, T | 1 |
| Wiznitzer, M | 1 |
| Rimland, B | 4 |
| Burd, L | 1 |
| Stenehjem, A | 1 |
| Franceschini, LA | 1 |
| Kerbeshian, J | 1 |
| Dreyfus, P | 1 |
| Siva Sankar, DV | 1 |
| Moss, N | 1 |
| Boverman, H | 1 |
| Arlot, JC | 1 |
| Sauvage, D | 1 |
| Domenech, J | 1 |
| Kleijnen, J | 1 |
| Knipschild, P | 1 |
| Roux, S | 1 |
| McDaniel, KD | 1 |
| Cheliakine, C | 1 |
4 reviews available for pyridoxine and Autism
| Article | Year |
|---|---|
New developments in pediatric psychopharmacology.
Topics: Adolescent; Adult; Aggression; Anorexia Nervosa; Antidepressive Agents, Tricyclic; Autistic Disorder | 1983 |
Efficacy of vitamin B6 and magnesium in the treatment of autism: a methodology review and summary of outcomes.
Topics: Autistic Disorder; Bias; Child; Humans; Magnesium; Orthomolecular Therapy; Pyridoxine; Randomized Co | 1995 |
Niacin and vitamin B6 in mental functioning: a review of controlled trials in humans.
Topics: Adult; Autistic Disorder; Child; Clinical Trials as Topic; Down Syndrome; Humans; Mental Disorders; | 1991 |
Controversies in the treatment of autistic children: vitamin and drug therapy.
Topics: Autistic Disorder; Child; Deanol; Fenfluramine; Humans; Magnesium; Pyridoxine; Thioridazine; Vitamin | 1988 |
8 trials available for pyridoxine and Autism
| Article | Year |
|---|---|
New developments in pediatric psychopharmacology.
Topics: Adolescent; Adult; Aggression; Anorexia Nervosa; Antidepressive Agents, Tricyclic; Autistic Disorder | 1983 |
Effects of pyridoxine and magnesium on autistic symptoms--initial observations.
Topics: Adolescent; Autistic Disorder; Child; Child, Preschool; Clinical Trials as Topic; Double-Blind Metho | 1981 |
Clinical and biological effects of high doses of vitamin B6 and magnesium on autistic children.
Topics: Adolescent; Autistic Disorder; Child; Child, Preschool; Double-Blind Method; Drug Therapy, Combinati | 1982 |
Brief report: lack of response in an autistic population to a low dose clinical trial of pyridoxine plus magnesium.
Topics: Adolescent; Autistic Disorder; Child; Communication Disorders; Double-Blind Method; Education; Femal | 1993 |
High-dose pyridoxine and magnesium administration in children with autistic disorder: an absence of salutary effects in a double-blind, placebo-controlled study.
Topics: Adolescent; Autistic Disorder; Child; Child, Preschool; Dose-Response Relationship, Drug; Double-Bli | 1997 |
High dose vitamin B6 and magnesium in treating autism: response to study by Findling et al.
Topics: Autistic Disorder; Child; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Magne | 1998 |
The effect of high doses of vitamin B6 on autistic children: a double-blind crossover study.
Topics: Adolescent; Autistic Disorder; Child; Child, Preschool; Clinical Trials as Topic; Dose-Response Rela | 1978 |
Vitamin B6, magnesium, and combined B6-Mg: therapeutic effects in childhood autism.
Topics: Autistic Disorder; Child; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; | 1985 |
11 other studies available for pyridoxine and Autism
| Article | Year |
|---|---|
Vitamin B deficiencies in a critically ill autistic child with a restricted diet.
Topics: Acidosis, Lactic; Autistic Disorder; Child; Critical Illness; Diet; Fast Foods; Feeding Behavior; He | 2015 |
Effects of vitamin B6 on averaged evoked potentials in infantile autism.
Topics: Autistic Disorder; Child; Dopamine; Evoked Potentials; Homovanillic Acid; Humans; Pyridoxine | 1981 |
Critique of "Efficacy of vitamin B6 and magnesium in the treatment of autism".
Topics: Autistic Disorder; Child; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Magne | 1998 |
A 15-year follow-up of a boy with pyridoxine (vitamin B6)-dependent seizures with autism, breath holding, and severe mental retardation.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Anticonvulsants; Autistic Disorder; Diagnosis, Dif | 2000 |
Plasma levels of folates, riboflavin, vitamin B6, and ascorbate in severely disturbed children.
Topics: Adolescent; Affective Symptoms; Ascorbic Acid; Autistic Disorder; Child; Child Behavior Disorders; C | 1979 |
Megavitamin therapy for autistic children.
Topics: Autistic Disorder; Child; Drug Evaluation; Humans; Orthomolecular Therapy; Pyridoxine; Research Desi | 1978 |
[Modifications in urinary homovanillic acid after ingestion of vitamin B6; functional study in autistic children (author's transl)].
Topics: Autistic Disorder; Child; Dopamine; Female; Homovanillic Acid; Humans; Male; Phenylacetates; Pyridox | 1978 |
Electrophysiological effects of fenfluramine or combined vitamin B6 and magnesium on children with autistic behaviour.
Topics: Autistic Disorder; Brain; Child; Child, Preschool; Evoked Potentials, Auditory; Female; Fenfluramine | 1989 |
Pharmacologic treatment of psychiatric and neurodevelopmental disorders in children and adolescents (Part 2).
Topics: Adolescent; Antipsychotic Agents; Autistic Disorder; Benzodiazepines; Child; Chlorpromazine; Haloper | 1986 |
Long-term effects of combined vitamin B6-magnesium administration in an autistic child.
Topics: Autistic Disorder; Child, Preschool; Drug Therapy, Combination; Evoked Potentials, Auditory; Homovan | 1986 |
Brief report: an open middle-term study of combined vitamin B6-magnesium in a subgroup of autistic children selected on their sensitivity to this treatment.
Topics: Autistic Disorder; Child; Child, Preschool; Dopamine; Drug Therapy, Combination; Evoked Potentials, | 1988 |