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pyridoxine and Atrophy

pyridoxine has been researched along with Atrophy in 21 studies

4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).

Atrophy: Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.

Research Excerpts

ExcerptRelevanceReference
"Four patients with gyrate atrophy on low protein (20-35 g/day), low arginine diets and one on vitamin B6 (300 mgm/day) have maintained their plasma ornithine concentrations in the range of 30-60% of pre-therapeutic trial levels for about two years."9.05A two year trial of low protein, low arginine diets or vitamin B6 for patients with gyrate atrophy. ( Berson, EL; Hanson, AH; Rosner, B; Shih, VE, 1982)
"Five patients with gyrate atrophy of the choroid and retina were examined ophthalmologically, especially ophthalmoscopically, to evaluate trials of vitamin B6 (pyridoxine) or supplementary proline."9.05Clinical trials of vitamin B6 and proline supplementation for gyrate atrophy of the choroid and retina. ( Hayasaka, S; Mizuno, K; Nakajima, H; Saito, T; Tada, K; Takahashi, O, 1985)
"Five patients, ages 12 to 30, with gyrate atrophy have shown substantial (60% or greater) decreases in plasma ornithine concentrations within four to eight weeks when placed on a therapeutic trial of low-protein (10-15 g/day), low-arginine diets supplemented with essential amino acids (EAA) and pyridoxine hydrochloride."7.66Ocular findings in patients with gyrate atrophy on pyridoxine and low-protein, low-arginine diets. ( Berson, EL; Shih, VE; Sullivan, PL, 1981)
"Four patients with gyrate atrophy on low protein (20-35 g/day), low arginine diets and one on vitamin B6 (300 mgm/day) have maintained their plasma ornithine concentrations in the range of 30-60% of pre-therapeutic trial levels for about two years."5.05A two year trial of low protein, low arginine diets or vitamin B6 for patients with gyrate atrophy. ( Berson, EL; Hanson, AH; Rosner, B; Shih, VE, 1982)
"Five patients with gyrate atrophy of the choroid and retina were examined ophthalmologically, especially ophthalmoscopically, to evaluate trials of vitamin B6 (pyridoxine) or supplementary proline."5.05Clinical trials of vitamin B6 and proline supplementation for gyrate atrophy of the choroid and retina. ( Hayasaka, S; Mizuno, K; Nakajima, H; Saito, T; Tada, K; Takahashi, O, 1985)
"The purpose of this study was to characterize the mutant enzyme in nine patients with gyrate atrophy of the choroid and retina associated with ornithine aminotransferase (OAT) deficiency, to elucidate the mechanism of response to pyridoxine in four pyridoxine-responsive patients, and to determine the extent of genetic heterogeneity in both groups of patients."3.67Gyrate atrophy of the choroid and retina: characterization of mutant ornithine aminotransferase and mechanism of response to vitamin B6. ( Kennaway, NG; Stankova, L; Weleber, RG; Wirtz, MK, 1989)
"Fibroblasts from four pyridoxine responsive and three non-responsive patients with gyrate atrophy of the choroid and retina have been examined."3.67Heterogeneity and complementation analysis of fibroblasts from vitamin B6 responsive and non-responsive patients with gyrate atrophy of the choroid and retina. ( Kennaway, NG; Weleber, RG; Wirtz, MK, 1985)
"Seven patients with gyrate atrophy and deficiency of ornithine-delta-aminotransferase were studied for in vivo pyridoxine responsiveness; three responded to oral vitamin B6 with over 50% reduction of serum ornithine levels and return to normal of serum lysine levels."3.66Clinical trial of vitamin B6 for gyrate atrophy of the choroid and retina. ( Kennaway, NG; Weleber, RG, 1981)
"Five patients, ages 12 to 30, with gyrate atrophy have shown substantial (60% or greater) decreases in plasma ornithine concentrations within four to eight weeks when placed on a therapeutic trial of low-protein (10-15 g/day), low-arginine diets supplemented with essential amino acids (EAA) and pyridoxine hydrochloride."3.66Ocular findings in patients with gyrate atrophy on pyridoxine and low-protein, low-arginine diets. ( Berson, EL; Shih, VE; Sullivan, PL, 1981)
"Pyridoxine dependency is an uncommon familial cause of intractable seizures in newborns and infants."1.30Longitudinal MRI findings in pyridoxine-dependent seizures. ( Gospe, SM; Hecht, ST, 1998)
" Additionally, one of our patients responded to high dosage vitamin B6 with a 27% reduction in plasma ornithine."1.26Clinical and biochemical heterogeneity in gyrate atrophy. ( Bron, AJ; Kaiser-Kupfer, MI; Valle, D, 1980)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-199019 (90.48)18.7374
1990's1 (4.76)18.2507
2000's0 (0.00)29.6817
2010's1 (4.76)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Al-Baradie, RS1
Chaudhary, MW1
STOERK, HC1
ZUSSMAN, WV1
Berson, EL4
Hanson, AH1
Rosner, B1
Shih, VE4
Weleber, RG5
Kennaway, NG5
Behrens-Baumann, W1
König, U1
Schröder, K1
Hansmann, I1
Langenbeck, U1
Hayasaka, S3
Shiono, T2
Mizuno, K3
Saito, T3
Tada, K3
Matsuzawa, T1
Ishiguro, I1
Wirtz, MK3
Sullivan, PL1
Nakajima, H2
Takaku, Y1
Ohmura, K1
Kaiser-Kupfer, MI1
Valle, D1
Bron, AJ1
Gospe, SM1
Hecht, ST1
Buist, NR1
Schmidt, SY1
Rodríguez Cuartero, A1
Montero García, M1
Pérez Gálvez, MN1
Mori, K1
Kaido, M1
Fujishiro, K1
Inoue, N1
Stankova, L1
Mandell, R1
Takahashi, O1
Hartmann-von Monakow, K1

Trials

2 trials available for pyridoxine and Atrophy

ArticleYear
A two year trial of low protein, low arginine diets or vitamin B6 for patients with gyrate atrophy.
    Birth defects original article series, 1982, Volume: 18, Issue:6

    Topics: Adolescent; Adult; Arginine; Atrophy; Child; Choroid; Clinical Trials as Topic; Dietary Proteins; Fe

1982
Clinical trials of vitamin B6 and proline supplementation for gyrate atrophy of the choroid and retina.
    The British journal of ophthalmology, 1985, Volume: 69, Issue:4

    Topics: Adolescent; Adult; Atrophy; Child; Child, Preschool; Choroid; Clinical Trials as Topic; Female; Huma

1985

Other Studies

19 other studies available for pyridoxine and Atrophy

ArticleYear
Diagnosis and management of cerebral folate deficiency. A form of folinic acid-responsive seizures.
    Neurosciences (Riyadh, Saudi Arabia), 2014, Volume: 19, Issue:4

    Topics: Atrophy; Brain; Brain Diseases, Metabolic, Inborn; Child Development Disorders, Pervasive; Child, Pr

2014
Effects of calcium deficiency and pyridoxin deficiency on thymic atrophy (accidental involution).
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1946, Volume: 62

    Topics: Atrophy; Calcium; Calcium Metabolism Disorders; Humans; Parathyroid Diseases; Pyridoxine; Thymus Gla

1946
SALIVARY AND SEBACEOUS GLAND ALTERATIONS IN RATS INGESTING N-2 FLUORENYLACETAMIDE.
    Archives of pathology, 1965, Volume: 80

    Topics: 2-Acetylaminofluorene; Adenocarcinoma; Atrophy; Carcinogens; Diethylstilbestrol; Ear Canal; Fluorene

1965
Clinical trial of vitamin B6 for gyrate atrophy of the choroid and retina.
    Ophthalmology, 1981, Volume: 88, Issue:4

    Topics: Analysis of Variance; Atrophy; Choroid; Dose-Response Relationship, Drug; Electroretinography; Human

1981
Biochemical and therapeutical studies in a case of atrophia gyrata.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1982, Volume: 218, Issue:1

    Topics: Adult; Atrophy; Choroid; Humans; Lysine; Male; Ornithine; Ornithine-Oxo-Acid Transaminase; Pedigree;

1982
Hyperornithinemia, gyrate atrophy, and ornithine ketoacid transaminase.
    Advances in experimental medicine and biology, 1982, Volume: 153

    Topics: Adolescent; Adult; Atrophy; Child; Child, Preschool; Choroid; Humans; Male; Ornithine; Ornithine-Oxo

1982
Gyrate atrophy of the choroid and retina: clinical and biochemical heterogeneity and response to vitamin B6.
    Birth defects original article series, 1982, Volume: 18, Issue:6

    Topics: Adult; Aged; Atrophy; Choroid; Female; Genes, Recessive; Humans; Male; Middle Aged; Ornithine; Ornit

1982
Ocular findings in patients with gyrate atrophy on pyridoxine and low-protein, low-arginine diets.
    Ophthalmology, 1981, Volume: 88, Issue:4

    Topics: Adolescent; Adult; Arginine; Atrophy; Child; Choroid; Dark Adaptation; Dietary Proteins; Electroreti

1981
Gyrate atrophy with hyperornithinaemia: different types of responsiveness to vitamin B6.
    The British journal of ophthalmology, 1981, Volume: 65, Issue:7

    Topics: Adolescent; Atrophy; Cells, Cultured; Child; Child, Preschool; Choroid; Fibroblasts; Humans; Lymphoc

1981
Clinical and biochemical heterogeneity in gyrate atrophy.
    American journal of ophthalmology, 1980, Volume: 89, Issue:2

    Topics: Adolescent; Adult; Atrophy; Cataract; Child; Choroid; Female; Genes; Humans; Ornithine; Ornithine-Ox

1980
Longitudinal MRI findings in pyridoxine-dependent seizures.
    Neurology, 1998, Volume: 51, Issue:1

    Topics: Atrophy; Brain; Child; Child, Preschool; Epilepsy; Female; gamma-Aminobutyric Acid; Glutamate Decarb

1998
Vitamin B6 in management of gyrate atrophy of choroid and retina.
    Lancet (London, England), 1978, Dec-02, Volume: 2, Issue:8101

    Topics: Administration, Oral; Atrophy; Choroid; Drug Evaluation; Humans; In Vitro Techniques; Ornithine-Oxo-

1978
Ocular and biochemical abnormalities in gyrate atrophy of the choroid and retina.
    Ophthalmology, 1978, Volume: 85, Issue:10

    Topics: Administration, Oral; Adolescent; Adult; Amino Acids; Atrophy; Child; Choroid; Dark Adaptation; Elec

1978
[Sideroblastic anemia sensitive to pyridoxine associated with atrophic gastritis].
    Revista clinica espanola, 1977, Jun-15, Volume: 145, Issue:5

    Topics: Anemia, Sideroblastic; Atrophy; Diagnosis, Differential; Female; Gastric Mucosa; Gastritis; Humans;

1977
Testicular damage induced by megadoses of pyridoxine.
    Journal of UOEH, 1989, Dec-01, Volume: 11, Issue:4

    Topics: Animals; Atrophy; Epididymis; Male; Organ Size; Pyridoxine; Rats; Rats, Inbred Strains; Sperm Count;

1989
Gyrate atrophy of the choroid and retina: characterization of mutant ornithine aminotransferase and mechanism of response to vitamin B6.
    American journal of human genetics, 1989, Volume: 44, Issue:3

    Topics: Atrophy; Cells, Cultured; Choroid; Enzyme Stability; Humans; Kinetics; Mutation; Ornithine-Oxo-Acid

1989
Pyridoxine effects on ornithine ketoacid transaminase activity in fibroblasts from carriers of two forms of gyrate atrophy of the choroid and retina.
    American journal of human genetics, 1988, Volume: 43, Issue:6

    Topics: Atrophy; Cell Line; Choroid; Enzyme Stability; Fibroblasts; Heterozygote; Humans; Ornithine-Oxo-Acid

1988
Heterogeneity and complementation analysis of fibroblasts from vitamin B6 responsive and non-responsive patients with gyrate atrophy of the choroid and retina.
    Journal of inherited metabolic disease, 1985, Volume: 8, Issue:2

    Topics: Atrophy; Choroid; Chromosome Mapping; Fibroblasts; Genetic Complementation Test; Humans; Ornithine-O

1985
[Therapy of cerebellar diseases].
    Bibliotheca psychiatrica et neurologica, 1969, Volume: 139

    Topics: Ascorbic Acid; Atrophy; Barbiturates; Carbamates; Cerebellar Ataxia; Cerebellar Cortex; Cerebellar D

1969