pyridoxine has been researched along with Atrophy in 21 studies
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
Atrophy: Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Four patients with gyrate atrophy on low protein (20-35 g/day), low arginine diets and one on vitamin B6 (300 mgm/day) have maintained their plasma ornithine concentrations in the range of 30-60% of pre-therapeutic trial levels for about two years." | 9.05 | A two year trial of low protein, low arginine diets or vitamin B6 for patients with gyrate atrophy. ( Berson, EL; Hanson, AH; Rosner, B; Shih, VE, 1982) |
| "Five patients with gyrate atrophy of the choroid and retina were examined ophthalmologically, especially ophthalmoscopically, to evaluate trials of vitamin B6 (pyridoxine) or supplementary proline." | 9.05 | Clinical trials of vitamin B6 and proline supplementation for gyrate atrophy of the choroid and retina. ( Hayasaka, S; Mizuno, K; Nakajima, H; Saito, T; Tada, K; Takahashi, O, 1985) |
| "Five patients, ages 12 to 30, with gyrate atrophy have shown substantial (60% or greater) decreases in plasma ornithine concentrations within four to eight weeks when placed on a therapeutic trial of low-protein (10-15 g/day), low-arginine diets supplemented with essential amino acids (EAA) and pyridoxine hydrochloride." | 7.66 | Ocular findings in patients with gyrate atrophy on pyridoxine and low-protein, low-arginine diets. ( Berson, EL; Shih, VE; Sullivan, PL, 1981) |
| "Four patients with gyrate atrophy on low protein (20-35 g/day), low arginine diets and one on vitamin B6 (300 mgm/day) have maintained their plasma ornithine concentrations in the range of 30-60% of pre-therapeutic trial levels for about two years." | 5.05 | A two year trial of low protein, low arginine diets or vitamin B6 for patients with gyrate atrophy. ( Berson, EL; Hanson, AH; Rosner, B; Shih, VE, 1982) |
| "Five patients with gyrate atrophy of the choroid and retina were examined ophthalmologically, especially ophthalmoscopically, to evaluate trials of vitamin B6 (pyridoxine) or supplementary proline." | 5.05 | Clinical trials of vitamin B6 and proline supplementation for gyrate atrophy of the choroid and retina. ( Hayasaka, S; Mizuno, K; Nakajima, H; Saito, T; Tada, K; Takahashi, O, 1985) |
| "The purpose of this study was to characterize the mutant enzyme in nine patients with gyrate atrophy of the choroid and retina associated with ornithine aminotransferase (OAT) deficiency, to elucidate the mechanism of response to pyridoxine in four pyridoxine-responsive patients, and to determine the extent of genetic heterogeneity in both groups of patients." | 3.67 | Gyrate atrophy of the choroid and retina: characterization of mutant ornithine aminotransferase and mechanism of response to vitamin B6. ( Kennaway, NG; Stankova, L; Weleber, RG; Wirtz, MK, 1989) |
| "Fibroblasts from four pyridoxine responsive and three non-responsive patients with gyrate atrophy of the choroid and retina have been examined." | 3.67 | Heterogeneity and complementation analysis of fibroblasts from vitamin B6 responsive and non-responsive patients with gyrate atrophy of the choroid and retina. ( Kennaway, NG; Weleber, RG; Wirtz, MK, 1985) |
| "Seven patients with gyrate atrophy and deficiency of ornithine-delta-aminotransferase were studied for in vivo pyridoxine responsiveness; three responded to oral vitamin B6 with over 50% reduction of serum ornithine levels and return to normal of serum lysine levels." | 3.66 | Clinical trial of vitamin B6 for gyrate atrophy of the choroid and retina. ( Kennaway, NG; Weleber, RG, 1981) |
| "Five patients, ages 12 to 30, with gyrate atrophy have shown substantial (60% or greater) decreases in plasma ornithine concentrations within four to eight weeks when placed on a therapeutic trial of low-protein (10-15 g/day), low-arginine diets supplemented with essential amino acids (EAA) and pyridoxine hydrochloride." | 3.66 | Ocular findings in patients with gyrate atrophy on pyridoxine and low-protein, low-arginine diets. ( Berson, EL; Shih, VE; Sullivan, PL, 1981) |
| "Pyridoxine dependency is an uncommon familial cause of intractable seizures in newborns and infants." | 1.30 | Longitudinal MRI findings in pyridoxine-dependent seizures. ( Gospe, SM; Hecht, ST, 1998) |
| " Additionally, one of our patients responded to high dosage vitamin B6 with a 27% reduction in plasma ornithine." | 1.26 | Clinical and biochemical heterogeneity in gyrate atrophy. ( Bron, AJ; Kaiser-Kupfer, MI; Valle, D, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (90.48) | 18.7374 |
| 1990's | 1 (4.76) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (4.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Al-Baradie, RS | 1 |
| Chaudhary, MW | 1 |
| STOERK, HC | 1 |
| ZUSSMAN, WV | 1 |
| Berson, EL | 4 |
| Hanson, AH | 1 |
| Rosner, B | 1 |
| Shih, VE | 4 |
| Weleber, RG | 5 |
| Kennaway, NG | 5 |
| Behrens-Baumann, W | 1 |
| König, U | 1 |
| Schröder, K | 1 |
| Hansmann, I | 1 |
| Langenbeck, U | 1 |
| Hayasaka, S | 3 |
| Shiono, T | 2 |
| Mizuno, K | 3 |
| Saito, T | 3 |
| Tada, K | 3 |
| Matsuzawa, T | 1 |
| Ishiguro, I | 1 |
| Wirtz, MK | 3 |
| Sullivan, PL | 1 |
| Nakajima, H | 2 |
| Takaku, Y | 1 |
| Ohmura, K | 1 |
| Kaiser-Kupfer, MI | 1 |
| Valle, D | 1 |
| Bron, AJ | 1 |
| Gospe, SM | 1 |
| Hecht, ST | 1 |
| Buist, NR | 1 |
| Schmidt, SY | 1 |
| Rodríguez Cuartero, A | 1 |
| Montero García, M | 1 |
| Pérez Gálvez, MN | 1 |
| Mori, K | 1 |
| Kaido, M | 1 |
| Fujishiro, K | 1 |
| Inoue, N | 1 |
| Stankova, L | 1 |
| Mandell, R | 1 |
| Takahashi, O | 1 |
| Hartmann-von Monakow, K | 1 |
2 trials available for pyridoxine and Atrophy
| Article | Year |
|---|---|
A two year trial of low protein, low arginine diets or vitamin B6 for patients with gyrate atrophy.
Topics: Adolescent; Adult; Arginine; Atrophy; Child; Choroid; Clinical Trials as Topic; Dietary Proteins; Fe | 1982 |
Clinical trials of vitamin B6 and proline supplementation for gyrate atrophy of the choroid and retina.
Topics: Adolescent; Adult; Atrophy; Child; Child, Preschool; Choroid; Clinical Trials as Topic; Female; Huma | 1985 |
19 other studies available for pyridoxine and Atrophy
| Article | Year |
|---|---|
Diagnosis and management of cerebral folate deficiency. A form of folinic acid-responsive seizures.
Topics: Atrophy; Brain; Brain Diseases, Metabolic, Inborn; Child Development Disorders, Pervasive; Child, Pr | 2014 |
Effects of calcium deficiency and pyridoxin deficiency on thymic atrophy (accidental involution).
Topics: Atrophy; Calcium; Calcium Metabolism Disorders; Humans; Parathyroid Diseases; Pyridoxine; Thymus Gla | 1946 |
SALIVARY AND SEBACEOUS GLAND ALTERATIONS IN RATS INGESTING N-2 FLUORENYLACETAMIDE.
Topics: 2-Acetylaminofluorene; Adenocarcinoma; Atrophy; Carcinogens; Diethylstilbestrol; Ear Canal; Fluorene | 1965 |
Clinical trial of vitamin B6 for gyrate atrophy of the choroid and retina.
Topics: Analysis of Variance; Atrophy; Choroid; Dose-Response Relationship, Drug; Electroretinography; Human | 1981 |
Biochemical and therapeutical studies in a case of atrophia gyrata.
Topics: Adult; Atrophy; Choroid; Humans; Lysine; Male; Ornithine; Ornithine-Oxo-Acid Transaminase; Pedigree; | 1982 |
Hyperornithinemia, gyrate atrophy, and ornithine ketoacid transaminase.
Topics: Adolescent; Adult; Atrophy; Child; Child, Preschool; Choroid; Humans; Male; Ornithine; Ornithine-Oxo | 1982 |
Gyrate atrophy of the choroid and retina: clinical and biochemical heterogeneity and response to vitamin B6.
Topics: Adult; Aged; Atrophy; Choroid; Female; Genes, Recessive; Humans; Male; Middle Aged; Ornithine; Ornit | 1982 |
Ocular findings in patients with gyrate atrophy on pyridoxine and low-protein, low-arginine diets.
Topics: Adolescent; Adult; Arginine; Atrophy; Child; Choroid; Dark Adaptation; Dietary Proteins; Electroreti | 1981 |
Gyrate atrophy with hyperornithinaemia: different types of responsiveness to vitamin B6.
Topics: Adolescent; Atrophy; Cells, Cultured; Child; Child, Preschool; Choroid; Fibroblasts; Humans; Lymphoc | 1981 |
Clinical and biochemical heterogeneity in gyrate atrophy.
Topics: Adolescent; Adult; Atrophy; Cataract; Child; Choroid; Female; Genes; Humans; Ornithine; Ornithine-Ox | 1980 |
Longitudinal MRI findings in pyridoxine-dependent seizures.
Topics: Atrophy; Brain; Child; Child, Preschool; Epilepsy; Female; gamma-Aminobutyric Acid; Glutamate Decarb | 1998 |
Vitamin B6 in management of gyrate atrophy of choroid and retina.
Topics: Administration, Oral; Atrophy; Choroid; Drug Evaluation; Humans; In Vitro Techniques; Ornithine-Oxo- | 1978 |
Ocular and biochemical abnormalities in gyrate atrophy of the choroid and retina.
Topics: Administration, Oral; Adolescent; Adult; Amino Acids; Atrophy; Child; Choroid; Dark Adaptation; Elec | 1978 |
[Sideroblastic anemia sensitive to pyridoxine associated with atrophic gastritis].
Topics: Anemia, Sideroblastic; Atrophy; Diagnosis, Differential; Female; Gastric Mucosa; Gastritis; Humans; | 1977 |
Testicular damage induced by megadoses of pyridoxine.
Topics: Animals; Atrophy; Epididymis; Male; Organ Size; Pyridoxine; Rats; Rats, Inbred Strains; Sperm Count; | 1989 |
Gyrate atrophy of the choroid and retina: characterization of mutant ornithine aminotransferase and mechanism of response to vitamin B6.
Topics: Atrophy; Cells, Cultured; Choroid; Enzyme Stability; Humans; Kinetics; Mutation; Ornithine-Oxo-Acid | 1989 |
Pyridoxine effects on ornithine ketoacid transaminase activity in fibroblasts from carriers of two forms of gyrate atrophy of the choroid and retina.
Topics: Atrophy; Cell Line; Choroid; Enzyme Stability; Fibroblasts; Heterozygote; Humans; Ornithine-Oxo-Acid | 1988 |
Heterogeneity and complementation analysis of fibroblasts from vitamin B6 responsive and non-responsive patients with gyrate atrophy of the choroid and retina.
Topics: Atrophy; Choroid; Chromosome Mapping; Fibroblasts; Genetic Complementation Test; Humans; Ornithine-O | 1985 |
[Therapy of cerebellar diseases].
Topics: Ascorbic Acid; Atrophy; Barbiturates; Carbamates; Cerebellar Ataxia; Cerebellar Cortex; Cerebellar D | 1969 |