pyridoxine has been researched along with Arthritis, Rheumatoid in 30 studies
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine if folinic acid supplementation during methotrexate (MTX) therapy for rheumatoid arthritis (RA) reduces both urinary 5-aminoimidazole-4-carboxamide (AICA) and urinary adenosine excretion more than does folic acid supplementation." | 9.11 | The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate-treated rheumatoid arthritis. ( Alarcón, GS; Baggott, JE; Lee, JY; Morgan, SL; Oster, RA, 2004) |
| "Twelve patients with rheumatoid arthritis who had failed to respond to or developed side effects preventing further use of penicillamine were given 5-thiopyridoxine (5-TP)." | 9.05 | 5-Thiopyridoxine in rheumatoid arthritis: clinical and experimental studies. ( Dieppe, PA; Huskisson, EC; Jaffe, IA; Scott, J, 1980) |
| "20 patients with active rheumatoid arthritis were treated for 12 weeks with the prostaglandin E1 precursors cis-linoleic acid and gamma-linolenic acid in the form of primrose evening oil (Efamol) and the co-factors zinc, ascorbic acid, niacin, and pyridoxin (Efavit)." | 7.66 | Treatment of rheumatoid arthritis with prostaglandin E1 precursors cis-linoleic acid and gamma-linolenic acid. ( Hansen, TM; Kassis, V; Lerche, A; Lorenzen, I; Søndergaard, J, 1983) |
| "Patients with rheumatoid arthritis have subnormal vitamin B6 status, both quantitatively and functionally." | 6.71 | Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis. ( Bagley, PJ; Chiang, EP; Dallal, G; Roubenoff, R; Selhub, J, 2005) |
| " Its indications in the therapy of RA were defined, and current principles of dosage were presented." | 5.26 | Penicillamine in rheumatoid arthritis: clinical pharmacology and biochemical properties. ( Jaffe, IA, 1979) |
| "To determine if folinic acid supplementation during methotrexate (MTX) therapy for rheumatoid arthritis (RA) reduces both urinary 5-aminoimidazole-4-carboxamide (AICA) and urinary adenosine excretion more than does folic acid supplementation." | 5.11 | The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate-treated rheumatoid arthritis. ( Alarcón, GS; Baggott, JE; Lee, JY; Morgan, SL; Oster, RA, 2004) |
| "Twelve patients with rheumatoid arthritis who had failed to respond to or developed side effects preventing further use of penicillamine were given 5-thiopyridoxine (5-TP)." | 5.05 | 5-Thiopyridoxine in rheumatoid arthritis: clinical and experimental studies. ( Dieppe, PA; Huskisson, EC; Jaffe, IA; Scott, J, 1980) |
| "20 patients with active rheumatoid arthritis were treated for 12 weeks with the prostaglandin E1 precursors cis-linoleic acid and gamma-linolenic acid in the form of primrose evening oil (Efamol) and the co-factors zinc, ascorbic acid, niacin, and pyridoxin (Efavit)." | 3.66 | Treatment of rheumatoid arthritis with prostaglandin E1 precursors cis-linoleic acid and gamma-linolenic acid. ( Hansen, TM; Kassis, V; Lerche, A; Lorenzen, I; Søndergaard, J, 1983) |
| "Patients with rheumatoid arthritis were found to have low plasma pyridoxal phosphate." | 3.65 | Vitamin B6 levels in rheumatoid arthritis: effect of treatment. ( Bernhart, FW; György, P; Schumacher, HR, 1975) |
| "Patients with rheumatoid arthritis have subnormal vitamin B6 status, both quantitatively and functionally." | 2.71 | Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis. ( Bagley, PJ; Chiang, EP; Dallal, G; Roubenoff, R; Selhub, J, 2005) |
| "Thus, urogenital tuberculosis was finally diagnosed in this patient." | 1.32 | [Unexpected complication in an elderly lady suffering from rheumatoid arthritis]. ( Furrer, J; Günthard, HF; Hättenschwiler, A; Schulthess, G, 2004) |
| "Pyridoxine may cause peripheral neuropathy and this case illustrates the need for caution in the use of this vitamin in the prevention and treatment of isoniazid induced peripheral neuropathy." | 1.28 | Exacerbation of isoniazid induced peripheral neuropathy by pyridoxine. ( Agnew, RA; Bucknall, RC; Nisar, M; Watkin, SW, 1990) |
| "An attempt to treat humans with Sjogren's syndrome by raising endogenous PGE1 production by administration of essential fatty acid PGE1 precursors, of pyridoxine and of vitamin C was successful in raising the rates of tear and saliva production." | 1.26 | Sjogren's syndrome and the sicca syndrome: the role of prostaglandin E1 deficiency. Treatment with essential fatty acids and vitamin C. ( Campbell, A; Horrobin, DF, 1980) |
| " Its indications in the therapy of RA were defined, and current principles of dosage were presented." | 1.26 | Penicillamine in rheumatoid arthritis: clinical pharmacology and biochemical properties. ( Jaffe, IA, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (80.00) | 18.7374 |
| 1990's | 3 (10.00) | 18.2507 |
| 2000's | 3 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| HAMMARSTEN, G | 1 |
| JONSSON, E | 1 |
| LUNDSTROM, M | 1 |
| NERI, A | 1 |
| NETTELBLADT, E | 1 |
| SANDELL, BM | 1 |
| BETT, IM | 2 |
| FLINN, JH | 1 |
| PRICE, JM | 1 |
| YESS, N | 1 |
| BROWN, RR | 1 |
| MCKUSICK, AB | 1 |
| SHERWIN, RW | 1 |
| JONES, LG | 1 |
| HSU, JM | 1 |
| Hättenschwiler, A | 1 |
| Furrer, J | 1 |
| Günthard, HF | 1 |
| Schulthess, G | 1 |
| Morgan, SL | 1 |
| Oster, RA | 1 |
| Lee, JY | 1 |
| Alarcón, GS | 1 |
| Baggott, JE | 1 |
| Chiang, EP | 1 |
| Selhub, J | 2 |
| Bagley, PJ | 1 |
| Dallal, G | 1 |
| Roubenoff, R | 2 |
| Ciocci, A | 1 |
| Ronchi, W | 1 |
| Bianchi, F | 1 |
| Hansen, TM | 1 |
| Lerche, A | 1 |
| Kassis, V | 1 |
| Lorenzen, I | 1 |
| Søndergaard, J | 1 |
| Huskisson, EC | 1 |
| Jaffe, IA | 4 |
| Scott, J | 1 |
| Dieppe, PA | 1 |
| Pool, KD | 1 |
| Feit, H | 1 |
| Kirkpatrick, J | 1 |
| Horrobin, DF | 1 |
| Campbell, A | 1 |
| Roubenoff, RA | 1 |
| Nadeau, MR | 1 |
| Cannon, JG | 1 |
| Freeman, LM | 1 |
| Dinarello, CA | 1 |
| Rosenberg, IH | 1 |
| Saurugg, D | 1 |
| Hodkewitsch, E | 1 |
| Sadek, IA | 1 |
| Schumacher, HR | 1 |
| Bernhart, FW | 1 |
| György, P | 1 |
| McCarty, DJ | 1 |
| Nisar, M | 1 |
| Watkin, SW | 1 |
| Bucknall, RC | 1 |
| Agnew, RA | 1 |
| Houpt, JB | 1 |
| Ogryzlo, MA | 1 |
| Hunt, M | 1 |
| Rylance, HJ | 1 |
| Myhal, DR | 1 |
| Gorini, M | 1 |
| Fattorini, A | 1 |
| Lake, B | 1 |
| Bruckner, FE | 1 |
| Smith, HG | 1 |
| Lakatos, C | 1 |
| Chamberlain, MA | 1 |
| Bianco, G | 1 |
| Marcolongo, R | 1 |
| Di Paolo, N | 1 |
| Salvatella Viñals, J | 1 |
| Ferré, LA | 1 |
| Barceló, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Mechanisms of Antifolate Efficacy in Arthritis[NCT00000395] | Phase 2 | 40 participants (Actual) | Interventional | 1996-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for pyridoxine and Arthritis, Rheumatoid
| Article | Year |
|---|---|
The antivitamin B 6 effect of penicillamine: clinical and immunological implications.
Topics: Antibody Formation; Arthritis, Rheumatoid; Drug Antagonism; Drug Interactions; Humans; Immunosuppres | 1972 |
4 trials available for pyridoxine and Arthritis, Rheumatoid
| Article | Year |
|---|---|
The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate-treated rheumatoid arthritis.
Topics: Adenosine; Aminoimidazole Carboxamide; Arthritis, Rheumatoid; Erythrocytes; Female; Folic Acid; Homo | 2004 |
Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Double-Blind Method; Female; Health Status; Humans; Inflammation; Male; Middl | 2005 |
5-Thiopyridoxine in rheumatoid arthritis: clinical and experimental studies.
Topics: Animals; Arthritis; Arthritis, Rheumatoid; Clinical Trials as Topic; Copper; Humans; Kynurenine; Mal | 1980 |
[Clinical experiences with an analgesic-acting infusion solution in neurological painful conditions].
Topics: Arthritis, Rheumatoid; Aspartic Acid; Dipyrone; Facial Neuralgia; Humans; Injections, Intravenous; M | 1977 |
25 other studies available for pyridoxine and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Growth promoting effect of amino acids and pyridoxine on bone marrow cultures from cases of rheumatoid arthritis.
Topics: Amino Acids; Arthritis; Arthritis, Rheumatoid; Bone Marrow; Humans; Pyridoxine | 1963 |
Effect of pyridoxine on tryptophan metabolism in rheumatoid arthritis.
Topics: Arthritis; Arthritis, Rheumatoid; Humans; Pyridoxine; Tryptophan | 1962 |
EXCRETION OF TRYPTOPHAN METABOLITES BY PATIENTS WITH RHEUMATOID ARTHRITIS.
Topics: Arthritis; Arthritis, Rheumatoid; Biomedical Research; Chromatography; Gout; Hippurates; Indoles; Ky | 1964 |
URINARY EXCRETION OF PYRIDOXINE AND 4-PYRIDOXIC ACID IN RHEUMATOID ARTHRITIS.
Topics: Arthritis; Arthritis, Rheumatoid; Chloroquine; Drug Therapy; Geriatrics; Humans; Metabolism; Pyridin | 1964 |
[Unexpected complication in an elderly lady suffering from rheumatoid arthritis].
Topics: Aged; Antibiotics, Antitubercular; Antitubercular Agents; Arthritis, Rheumatoid; Diagnosis, Differen | 2004 |
[On the anti-rheumatic activity of a drug combination. Clinical experimentation].
Topics: Adult; Aged; Aminopyrine; Analgesics; Arthritis, Rheumatoid; Child; Female; Gout; Humans; Interverte | 1967 |
[Use in geriatric therapy of a new preparation with anti-rheumatic action].
Topics: Aged; Aminopyrine; Analgesics; Arthritis, Rheumatoid; Female; Herpes Zoster; Humans; Male; Neuritis; | 1967 |
Treatment of rheumatoid arthritis with prostaglandin E1 precursors cis-linoleic acid and gamma-linolenic acid.
Topics: Adult; Aged; Arthritis, Rheumatoid; Ascorbic Acid; Cyclic AMP; Cyclic GMP; Drug Combinations; Fatty | 1983 |
Penicillamine-induced neuropathy in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Female; Humans; Middle Aged; Nervous System Diseases; Neural Conduction; Peni | 1981 |
Sjogren's syndrome and the sicca syndrome: the role of prostaglandin E1 deficiency. Treatment with essential fatty acids and vitamin C.
Topics: Arthritis, Rheumatoid; Ascorbic Acid; Fatty Acids, Essential; Female; Humans; Lacrimal Apparatus Dis | 1980 |
Abnormal vitamin B6 status in rheumatoid cachexia. Association with spontaneous tumor necrosis factor alpha production and markers of inflammation.
Topics: Adult; Aged; Arthritis, Rheumatoid; Cachexia; Cross-Sectional Studies; Diet; Endotoxins; Female; Fol | 1995 |
Nyctotheroides puytoraci: stimulation of encystment in toads, Bufo regularis, injected with rheumatoid arthritis patients' urine.
Topics: Animals; Arthritis, Rheumatoid; Bufonidae; Ciliophora; Humans; Pyridoxine; Tryptophan | 1979 |
Penicillamine in rheumatoid arthritis: clinical pharmacology and biochemical properties.
Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Collagen; Cystine; Drug Evaluation; Humans; Penicillamin | 1979 |
Vitamin B6 levels in rheumatoid arthritis: effect of treatment.
Topics: Adult; Aged; Arthritis, Rheumatoid; Blood Sedimentation; Dose-Response Relationship, Drug; Female; H | 1975 |
Complete reversal of rheumatoid nodulosis.
Topics: Arthritis, Rheumatoid; Female; Humans; Hydroxychloroquine; Middle Aged; Penicillamine; Pyridoxine; R | 1991 |
Exacerbation of isoniazid induced peripheral neuropathy by pyridoxine.
Topics: Acetylation; Arthritis, Rheumatoid; Ethambutol; Humans; Isoniazid; Male; Middle Aged; Mycobacterium | 1990 |
Tryptophan metabolism in man (with special reference to rheumatoid arthritis and scleroderma).
Topics: Arthritis, Rheumatoid; Aspirin; Cystinuria; Drug Synergism; Edetic Acid; Humans; Kynurenic Acid; Kyn | 1973 |
Taurine excretion and the influence of drugs.
Topics: Adrenocorticotropic Hormone; Aminoisobutyric Acids; Anti-Inflammatory Agents; Arthritis, Rheumatoid; | 1971 |
[Clinical research on the therapeutic use of orthoxyquinoline sulfonate of dimethyl-diphenyl-amino-isopyrazolone in association with vitamins B 6 and B 12].
Topics: Adult; Aminopyrine; Analgesics; Arthritis, Rheumatoid; Female; Fever; Humans; Male; Middle Aged; Neu | 1967 |
Rheumatoid arthritis and malabsorption.
Topics: Arthritis, Rheumatoid; Humans; Intestinal Absorption; Penicillamine; Pyridoxine | 1972 |
Tryptophan metabolism in rheumatoid neuropathies.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Arthritis, Rheumatoid; Aspirin; Child; Child, Pres | 1972 |
Antivitamin B6 effect of D-penicillamine.
Topics: Arthritis, Rheumatoid; Humans; Kynurenine; Penicillamine; Pyridoxine; Rheumatoid Factor; Stereoisome | 1969 |
[Clinical observations on the therapeutic effect of a new synthetic preparation in rheumatic diseases].
Topics: Acetates; Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Male; Middle Aged; Neuralgia; Periarth | 1970 |
[Results of personal experience with a sulfamide preparation associated with lysine orotate and pyridoxine hydrochloride, in the treatment of rheumatism of degenerative origin].
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Humans; Lysine; Male; Middle Aged; Orotic Acid; Pyridoxi | 1970 |
Urinary tryptophan metabolites in rheumatoid arthritis and some other diseases.
Topics: Arthritis, Rheumatoid; Female; Humans; Hyaluronic Acid; Kynurenine; Male; ortho-Aminobenzoates; Pyri | 1966 |