pyridoxine has been researched along with Alcoholic Intoxication in 19 studies
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
Alcoholic Intoxication: An acute brain syndrome which results from the excessive ingestion of ETHANOL or ALCOHOLIC BEVERAGES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sixty patients, recognized as chronic alcoholics on the grounds of the case history and with a score above 11 of the Munich Alcoholism Test (MALT) have been treated with metadoxine or placebo for thirty days according to a double blind randomized design." | 9.07 | [Therapeutic use of metadoxine in chronic alcoholism. Double blind study of patients in a department of general medicine]. ( Breda, A; Dotta, C; Gelso, E; Moretto, F; Pace, M; Rizzo, A; Sanzuol, F; Tossani, C, 1993) |
| "The therapeutic effect of metadoxine on alcoholic and non-alcoholic steatohepatitis." | 8.82 | [The therapeutic effect of metadoxine on alcoholic and non-alcoholic steatohepatitis]. ( Blázovics, A; Fehér, J; Váli, L, 2005) |
| "Sixty patients, recognized as chronic alcoholics on the grounds of the case history and with a score above 11 of the Munich Alcoholism Test (MALT) have been treated with metadoxine or placebo for thirty days according to a double blind randomized design." | 5.07 | [Therapeutic use of metadoxine in chronic alcoholism. Double blind study of patients in a department of general medicine]. ( Breda, A; Dotta, C; Gelso, E; Moretto, F; Pace, M; Rizzo, A; Sanzuol, F; Tossani, C, 1993) |
| "The therapeutic effect of metadoxine on alcoholic and non-alcoholic steatohepatitis." | 4.82 | [The therapeutic effect of metadoxine on alcoholic and non-alcoholic steatohepatitis]. ( Blázovics, A; Fehér, J; Váli, L, 2005) |
| "Treatment with metadoxine significantly decreased the half-life of ethanol in blood (from 6." | 2.70 | Metadoxine in acute alcohol intoxication: a double-blind, randomized, placebo-controlled study. ( Addolorato, G; Gasbarrini, G; Muzychenko, AP; Shpilenya, LS, 2002) |
| " A single dose of ethanol initially activates the GABA system which is weakened after chronic administration because of overcompensation." | 2.36 | Ethanol and GABA. ( Kulonen, E, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (57.89) | 18.7374 |
| 1990's | 4 (21.05) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Mirijello, A | 1 |
| Addolorato, G | 3 |
| Vonghia, L | 1 |
| Leggio, L | 1 |
| Ferrulli, A | 1 |
| Bertini, M | 1 |
| Gasbarrini, G | 2 |
| NEWMAN, H | 1 |
| SMITH, ME | 1 |
| CELICE, J | 1 |
| DUCHESNAY, G | 1 |
| TEIJEIRA, J | 1 |
| MARTINEZ-LAGE, JM | 1 |
| SMALL, MD | 1 |
| ZAMCHECK, N | 1 |
| VITALE, JJ | 1 |
| LONGARINI, A | 1 |
| FISCHER, B | 1 |
| Váli, L | 1 |
| Blázovics, A | 1 |
| Fehér, J | 1 |
| Kulonen, E | 1 |
| Felicioli, R | 1 |
| Saracchi, I | 1 |
| Flagiello, AM | 1 |
| Bartoli, C | 1 |
| Mardel, S | 1 |
| Phair, I | 1 |
| O'Dwyer, F | 1 |
| Henry, JA | 1 |
| Gallant, DM | 1 |
| Rizzo, A | 1 |
| Breda, A | 1 |
| Moretto, F | 1 |
| Pace, M | 1 |
| Dotta, C | 1 |
| Gelso, E | 1 |
| Sanzuol, F | 1 |
| Tossani, C | 1 |
| Calabrese, V | 2 |
| Calderone, A | 1 |
| Ragusa, N | 1 |
| Rizza, V | 2 |
| Shpilenya, LS | 1 |
| Muzychenko, AP | 1 |
| Vech, RL | 1 |
| Lumeng, L | 1 |
| Li, TK | 1 |
| Ramirez, M | 1 |
| de Bernardis, E | 1 |
| Khan, MA | 1 |
| Jensen, K | 1 |
| Krogh, HJ | 1 |
| Hillbom, ME | 1 |
| Linkola, J | 1 |
| Nikander, P | 1 |
| Wallgren, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Novel Pharmacotherapy for Alcoholism and Alcohol Liver Disease[NCT01504295] | Phase 2 | 38 participants (Actual) | Interventional | 2012-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for pyridoxine and Alcoholic Intoxication
| Article | Year |
|---|---|
Acute alcohol intoxication.
Topics: Acute Disease; Alcohol Deterrents; Alcoholic Intoxication; Ataxia; Coma; Diagnosis, Differential; Dr | 2008 |
[The therapeutic effect of metadoxine on alcoholic and non-alcoholic steatohepatitis].
Topics: Alcohol Deterrents; Alcoholic Intoxication; Alcoholism; Drug Combinations; Fatty Liver; Fatty Liver, | 2005 |
Ethanol and GABA.
Topics: 4-Aminobutyrate Transaminase; Alcoholic Intoxication; Alcoholism; Animals; Benzodiazepines; Brain; C | 1983 |
4 trials available for pyridoxine and Alcoholic Intoxication
| Article | Year |
|---|---|
Intravenous pyridoxine in acute ethanol intoxication.
Topics: Adult; Alcoholic Intoxication; Double-Blind Method; Female; Glasgow Coma Scale; Humans; Injections, | 1994 |
[Therapeutic use of metadoxine in chronic alcoholism. Double blind study of patients in a department of general medicine].
Topics: Alcoholic Intoxication; Alcoholism; Double-Blind Method; Drug Combinations; Drug Evaluation; Female; | 1993 |
Metadoxine in acute alcohol intoxication: a double-blind, randomized, placebo-controlled study.
Topics: Adult; Alcohol Deterrents; Alcoholic Intoxication; Analysis of Variance; Chi-Square Distribution; Do | 2002 |
Alcohol-induced hangover. A double-blind comparison of pyritinol and placebo in preventing hangover symptoms.
Topics: Adult; Alcohol Drinking; Alcoholic Intoxication; Amnesia; Clinical Trials as Topic; Disulfides; Envi | 1973 |
12 other studies available for pyridoxine and Alcoholic Intoxication
| Article | Year |
|---|---|
Treatment of acute alcohol intoxication: The role of metadoxine.
Topics: Alcoholic Intoxication; Alcoholism; Drug Combinations; Humans; Pyridoxine; Pyrrolidonecarboxylic Aci | 2023 |
Effect of pyridoxine in acute alcoholic intoxication.
Topics: Alcoholic Intoxication; Alcoholism; Pyridoxine; Vitamin B 6 | 1959 |
[Usefulness of pyridoxol (vitamin B6) in the treatment of neurological manifestations of alcoholic intoxication].
Topics: Alcoholic Intoxication; Humans; Nervous System Diseases; Pyridoxine; Vitamin B 6 | 1959 |
[Antagonism between pyridoxine and pyridoxine disulfate and ethyl alcohol].
Topics: Alcoholic Intoxication; Ethanol; Hostility; Pyridoxine; Vitamin B 6 | 1961 |
The effect of pyridoxine hydrochloride in acute alcoholic intoxication.
Topics: Alcoholic Intoxication; Alcoholism; Pyridoxine; Vitamin B 6 | 1955 |
Effects of pyridoxine-pyrrolidon-carboxylate on hepatic and cerebral ATP levels in ethanol treated rats.
Topics: Adenosine Triphosphate; Alcoholic Intoxication; Animals; Brain Chemistry; Drug Combinations; Humans; | 1980 |
Pyridoxine therapy for ethanol toxicity?
Topics: Alcoholic Intoxication; Animals; Dose-Response Relationship, Drug; Ethanol; Humans; Injections, Intr | 1993 |
Effects of Metadoxine on cellular status of glutathione and of enzymatic defence system following acute ethanol intoxication in rats.
Topics: Alcoholic Intoxication; Animals; Brain; Drug Combinations; Glutathione; Glutathione Peroxidase; Glut | 1996 |
Vitamin B6 metabolism in chronic alcohol abuse The effect of ethanol oxidation on hepatic pyridoxal 5'-phosphate metabolism.
Topics: Acute Disease; Alcoholic Intoxication; Animals; Chronic Disease; Humans; In Vitro Techniques; Liver; | 1975 |
Inebriation with pyridoxine and fluoroacetate: a case report.
Topics: Adult; Alcoholic Intoxication; Antidotes; Ethanol; Fluoroacetates; Humans; Male; Pyridoxine | 1986 |
[Metadoxine in the control of oxidative stress caused by acute and chronic ethanol poisoning].
Topics: Alcohol Dehydrogenase; Alcoholic Intoxication; Alcoholism; Aldehyde Dehydrogenase; Animals; Drug Com | 1986 |
Effects of pyrithioxine, EMD 17246 and diethanolamine-rutin on acute alcoholic intoxication in rats.
Topics: Administration, Oral; Alcoholic Intoxication; Animals; Behavior, Animal; Depression, Chemical; Dose- | 1973 |