pyridoxine has been researched along with Adverse Drug Event in 15 studies
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Levetiracetam (LEV) is an anti-seizure medication (ASM) known to have significant behavioral side effects in children with epilepsy." | 8.12 | Vitamin B6 decreases the risk of levetiracetam discontinuation in children with epilepsy: A retrospective study. ( Bartolini, L; Bassell-Hawkins, J; Lob, K; Nie, D; Patil, R, 2022) |
| "This study was a randomized double-blind placebo-controlled clinical trial on 53 adult patients with epilepsy with behavioral side effects after treatment by levetiracetam." | 5.51 | Pyridoxine for treatment of levetiracetam-induced behavioral adverse events: A randomized double-blind placebo-controlled trial. ( Alizadeh-Navaei, R; Asghari, F; Cheraghmakani, H; Ghazaeian, M; Rezapour, M; Tabrizi, N, 2022) |
| "Levetiracetam (LEV) is an anti-seizure medication (ASM) known to have significant behavioral side effects in children with epilepsy." | 4.12 | Vitamin B6 decreases the risk of levetiracetam discontinuation in children with epilepsy: A retrospective study. ( Bartolini, L; Bassell-Hawkins, J; Lob, K; Nie, D; Patil, R, 2022) |
| "Levetiracetam (LVT), while an effective treatment for multiple seizure types, is associated with a high incidence of neuropsychiatric adverse events (NPAEs)." | 3.01 | Current evidence for adjunct pyridoxine (vitamin B6) for the treatment of behavioral adverse effects associated with levetiracetam: A systematic review. ( Besag, FMC; Sen, A; Vasey, MJ, 2023) |
| "Levetiracetam is a relatively new-generation antiseizure drug approved for the treatment of focal and generalized seizures." | 3.01 | Amelioration of Levetiracetam-Induced Behavioral Side Effects by Pyridoxine. A Randomized Double Blind Controlled Study. ( Al Enazi, S; Al Otaibi, A; Al Wadei, A; Benini, R; Jad, L; Lubbad, N; Mahmoud, A; Tabassum, S, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (46.67) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 5 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Dawson, S | 1 |
| Stahl, S | 1 |
| Paul, N | 1 |
| Barber, J | 1 |
| Kenna, JG | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| García, FG | 1 |
| Cardon, M | 1 |
| Cardon, AL | 1 |
| Lob, K | 1 |
| Bassell-Hawkins, J | 1 |
| Patil, R | 1 |
| Nie, D | 1 |
| Bartolini, L | 1 |
| Cheraghmakani, H | 1 |
| Rezapour, M | 1 |
| Asghari, F | 1 |
| Alizadeh-Navaei, R | 1 |
| Ghazaeian, M | 1 |
| Tabrizi, N | 1 |
| Besag, FMC | 1 |
| Vasey, MJ | 1 |
| Sen, A | 1 |
| Mahmoud, A | 1 |
| Tabassum, S | 1 |
| Al Enazi, S | 1 |
| Lubbad, N | 1 |
| Al Wadei, A | 1 |
| Al Otaibi, A | 1 |
| Jad, L | 1 |
| Benini, R | 1 |
| CHENEBAULT, J | 1 |
| Dickerson, JW | 1 |
| Niebyl, JR | 1 |
| Smith, R | 1 |
| Koren, G | 1 |
| Pastuszak, A | 1 |
| Ito, S | 1 |
| Springer, NS | 1 |
| Fricke, NL | 1 |
| Aselton, P | 1 |
| Jick, H | 1 |
| Milunsky, A | 1 |
| Hunter, JR | 1 |
| Stergachis, A | 1 |
| Mayer, J | 1 |
4 reviews available for pyridoxine and Adverse Drug Event
| Article | Year |
|---|---|
Current evidence for adjunct pyridoxine (vitamin B6) for the treatment of behavioral adverse effects associated with levetiracetam: A systematic review.
Topics: Drug-Related Side Effects and Adverse Reactions; Humans; Levetiracetam; Pyridoxine; Randomized Contr | 2023 |
Nutrition of the cancer patient.
Topics: Anorexia; Ascorbic Acid; Cachexia; Drug-Related Side Effects and Adverse Reactions; Enteral Nutritio | 1983 |
Drugs in pregnancy.
Topics: Abnormalities, Drug-Induced; Animals; Counseling; Dicyclomine; Doxylamine; Drug Combinations; Drug E | 1998 |
Nutrition and drug therapy for persons with developmental disabilities.
Topics: Anticonvulsants; Antidepressive Agents; Appetite; Dextroamphetamine; Drug-Related Side Effects and A | 1975 |
2 trials available for pyridoxine and Adverse Drug Event
| Article | Year |
|---|---|
Pyridoxine for treatment of levetiracetam-induced behavioral adverse events: A randomized double-blind placebo-controlled trial.
Topics: Adult; Anticonvulsants; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Epilep | 2022 |
Amelioration of Levetiracetam-Induced Behavioral Side Effects by Pyridoxine. A Randomized Double Blind Controlled Study.
Topics: Anticonvulsants; Behavioral Symptoms; Child; Child, Preschool; Double-Blind Method; Drug-Related Sid | 2021 |
9 other studies available for pyridoxine and Adverse Drug Event
| Article | Year |
|---|---|
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Observations Regarding Recently Published Amelioration of Levetiracetam-Induced Behavioral Side Effects by Pyridoxine.
Topics: Anticonvulsants; Drug-Related Side Effects and Adverse Reactions; Humans; Levetiracetam; Piracetam; | 2022 |
Vitamin B6 decreases the risk of levetiracetam discontinuation in children with epilepsy: A retrospective study.
Topics: Anticonvulsants; Child; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Humans; Levetirac | 2022 |
[ACUTE ISONIAZID POISONING].
Topics: Clinical Laboratory Techniques; Diagnosis; Drug-Related Side Effects and Adverse Reactions; Isoniazi | 1964 |
Therapeutic drugs in pregnancy. Caution is the watchword.
Topics: Abnormalities, Drug-Induced; Analgesics; Anti-Bacterial Agents; Anti-Infective Agents; Anticonvulsan | 1984 |
Product liability all dressed up American style.
Topics: Antiemetics; Dicyclomine; Diethylstilbestrol; Doxylamine; Drug Combinations; Drug Industry; Drug Lab | 1981 |
First-trimester drug use and congenital disorders.
Topics: Abnormalities, Drug-Induced; Brompheniramine; Congenital Abnormalities; Dicyclomine; Doxylamine; Dru | 1985 |
Iatrogenic malnutrition.
Topics: Adolescent; Anemia, Macrocytic; Anticonvulsants; Antitubercular Agents; Calcium; Celiac Disease; Chi | 1971 |