pyridoxine has been researched along with Acute Liver Injury, Drug-Induced in 25 studies
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pyridoxine treatment significantly increased cell viability and decreased leakage of LDH activity against APAP-induced hepatotoxicity in HepG2 cells." | 1.48 | Detoxifying effect of pyridoxine on acetaminophen-induced hepatotoxicity via suppressing oxidative stress injury. ( Choi, SM; De, U; Kacew, S; Kim, HS; Kim, MK; Lee, BM; Lim, DS; Lim, SK; Roh, T; Yoon, S, 2018) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (56.00) | 18.7374 |
| 1990's | 1 (4.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 10 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Dawson, S | 1 |
| Stahl, S | 2 |
| Paul, N | 1 |
| Barber, J | 1 |
| Kenna, JG | 2 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Roh, T | 1 |
| De, U | 1 |
| Lim, SK | 1 |
| Kim, MK | 1 |
| Choi, SM | 1 |
| Lim, DS | 1 |
| Yoon, S | 1 |
| Kacew, S | 1 |
| Kim, HS | 1 |
| Lee, BM | 1 |
| Colucci, G | 1 |
| Silzle, T | 1 |
| Solenthaler, M | 1 |
| Minushkin, ON | 1 |
| Maslovskiĭ, LV | 1 |
| Bukshuk, AA | 1 |
| COTTIN, S | 1 |
| COZAN, R | 1 |
| VERAN, P | 1 |
| FRANK, O | 2 |
| BAKER, H | 2 |
| LEEVY, CM | 2 |
| LUDWIG, H | 1 |
| EWALD, W | 1 |
| ROKA, L | 1 |
| Nagami, P | 1 |
| Yoshikawa, TT | 1 |
| Heisey, GB | 1 |
| Hughes, HC | 1 |
| Lang, CM | 1 |
| Rozmiarek, H | 1 |
| Antoshin, IuV | 1 |
| Blowey, DL | 1 |
| Johnson, D | 1 |
| Verjee, Z | 1 |
| Nami, R | 1 |
| Chioléro, R | 1 |
| Goldman, AL | 1 |
| Braman, SS | 1 |
| Bailey, WC | 1 |
| Taylor, SL | 1 |
| Dascomb, HE | 1 |
| Greenberg, HB | 1 |
| Ziskind, MM | 1 |
| Luisada-Opper, AV | 1 |
| Feingold, S | 1 |
| Di Rosa, M | 1 |
| Pasechnik, IKh | 1 |
| Sytnik, IA | 1 |
| Nogachevskiĭ, II | 1 |
3 reviews available for pyridoxine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Aging and tuberculosis.
Topics: Aged; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Ethambutol; Female; Humans; | 1984 |
Pyridoxine and its metabolism in chronic liver disease.
Topics: Alcoholism; Chemical and Drug Induced Liver Injury; Chronic Disease; Humans; Liver; Liver Diseases; | 1977 |
1 trial available for pyridoxine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
[Rifampicin in the treatment of active pulmonary tuberculosis. Controlled trial of isoniazid-rifampicin-thiocarlide versus isoniazid-streptomycin-thiocarlide in untreated tuberculosis. Treatment of relapses with the combination rifampicin-ethambutol-thioc
Topics: Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Drug Hypersensitivity; Drug Therap | 1974 |
21 other studies available for pyridoxine and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Detoxifying effect of pyridoxine on acetaminophen-induced hepatotoxicity via suppressing oxidative stress injury.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 2018 |
Pyrazinamide-induced sideroblastic anemia.
Topics: 5-Aminolevulinate Synthetase; alpha-Thalassemia; Anemia, Sideroblastic; Antitubercular Agents; Aza C | 2012 |
[The use of hepatic protectors in clinical practice].
Topics: Amino Acids; Chemical and Drug Induced Liver Injury; Cytoprotection; Drug Combinations; Flavonoids; | 2012 |
[APROPOS OF ETHIONAMIDE JAUNDICE].
Topics: Alanine Transaminase; Alcoholism; Aminosalicylic Acid; Aminosalicylic Acids; Aspartate Aminotransfer | 1964 |
VITAMIN-BINDING CAPACITY OF EXPERIMENTALLY INJURED LIVER.
Topics: Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Folic Acid; Hepatitis; Leuco | 1964 |
[ON TRANSAMINASES PARTICIPATING IN THE CONVERSION OF TYROSINE TO P-HYDROXYPHENYLPYRUVATE].
Topics: Chemical and Drug Induced Liver Injury; Enzyme Inhibitors; Hepatitis; Hydrocortisone; Isoniazid; Liv | 1964 |
The guinea pig as a model for isoniazid-induced reactions.
Topics: Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Disease Models, Animal | 1980 |
[Use of vitamins E and B6 for preventing and treating experimental liver dystrophy causeds by hydrazine hydrate].
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Evaluation, Preclinical; Drug Therapy, Combina | 1980 |
Isoniazid-associated rhabdomyolysis.
Topics: Adolescent; Charcoal; Chemical and Drug Induced Liver Injury; Diazepam; Female; Humans; Isoniazid; P | 1995 |
[Hepatic damage caused by drugs and evaluation of the therapeutic effectiveness of pyridoxine pyrrolidone carboxylate].
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Hepatitis, Alcoholic; Humans; Liver Dis | 1979 |
Isoniazid: a review with emphasis on adverse effects.
Topics: Anemia, Hemolytic; Chemical and Drug Induced Liver Injury; Desensitization, Immunologic; Drug Hypers | 1972 |
Disturbed hepatic function during isoniazid chemoprophylaxis. Monitoring the hepatic function of 427 hospital employees receiving isoniazid chemoprophylaxis for tuberculosis.
Topics: Adult; Aged; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Black or African American | 1973 |
Effect of CCl4 on the vitamin-protein profile of rat liver subcellular elements.
Topics: Animals; Ascorbic Acid; Biotin; Carbon Tetrachloride Poisoning; Centrifugation; Chemical and Drug In | 1970 |
[Blood ammonia antagonistic and hepatoprotective effect of a combination of arginine, taurine and vitamin B6 pyrrolidon-carboxylate].
Topics: Ammonia; Animals; Arginine; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; | 1967 |
[Fagocytic activity of leukocytes during treatment of experimental hepatitis with vitamin B6].
Topics: Animals; Chemical and Drug Induced Liver Injury; Leukocytes; Phagocytosis; Pyridoxine; Rats | 1965 |