pyridoxine has been researched along with Acidosis in 27 studies
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
Acidosis: A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pyridoxine hydrochloride, the antidote for isonicotinic acid hydrazide (INH)--induced seizures, is available in solution at a concentration of 100 mg/mL at a pH of less than 3." | 9.09 | Intravenous pyridoxine-induced metabolic acidosis. ( Curry, SC; Graeme, KA; Lovecchio, F; Suchard, J; Wallace, KL, 2001) |
| " Acute isoniazid intoxication is characterized by a clinical triad consisting of metabolic acidosis resistant to treatment with sodium bicarbonate, seizures which may be fatal and refractory to standard anticonvulsant therapy, and coma." | 7.73 | Seizures, metabolic acidosis and coma resulting from acute isoniazid intoxication. ( Ekici, NZ; Kefi, A; Sakarya, M; Topcu, I; Yentur, EA, 2005) |
| "Acute metabolic acidosis associated with accumulation of lactate has been previously reported in isoniazid (INH) intoxication." | 7.67 | Association of beta hydroxybutyric acidosis with isoniazid intoxication. ( Maksy, M; Nathan, R; Ness, R; Pahl, MV; Vaziri, ND, 1984) |
| "Isoniazid (INH) is an integral component of treatment of tuberculosis." | 5.35 | Isoniazid toxicity presenting as status epilepticus and severe metabolic acidosis. ( Gokhale, YA; Mehta, AD; Rathod, NN; Vaidya, MS, 2009) |
| "She was in respiratory failure, with seizures that could not be stopped with diazepam." | 5.29 | [Pyridoxine for severe metabolic acidosis and seizures due to isoniazid overdose]. ( Adler, M; Girsh-Solomonovich, Z; Raikhlin-Eisenkraft, B, 1993) |
| "Pyridoxine hydrochloride, the antidote for isonicotinic acid hydrazide (INH)--induced seizures, is available in solution at a concentration of 100 mg/mL at a pH of less than 3." | 5.09 | Intravenous pyridoxine-induced metabolic acidosis. ( Curry, SC; Graeme, KA; Lovecchio, F; Suchard, J; Wallace, KL, 2001) |
| " Acute isoniazid intoxication is characterized by a clinical triad consisting of metabolic acidosis resistant to treatment with sodium bicarbonate, seizures which may be fatal and refractory to standard anticonvulsant therapy, and coma." | 3.73 | Seizures, metabolic acidosis and coma resulting from acute isoniazid intoxication. ( Ekici, NZ; Kefi, A; Sakarya, M; Topcu, I; Yentur, EA, 2005) |
| "Acute metabolic acidosis associated with accumulation of lactate has been previously reported in isoniazid (INH) intoxication." | 3.67 | Association of beta hydroxybutyric acidosis with isoniazid intoxication. ( Maksy, M; Nathan, R; Ness, R; Pahl, MV; Vaziri, ND, 1984) |
| "Acute isoniazid intoxication is characterised by high mortality and vomiting, seizures, coma and metabolic acidosis as main symptoms." | 3.67 | [Acute isoniazid poisoning]. ( Bode, U; Köster, B; Musch, E; Weber, HP, 1985) |
| "Large doses of pyridoxine recently have been shown to prevent the seizures and acidosis caused by ingestion of more than two to three grams of isoniazid." | 3.66 | Isoniazid overdose treated with high-dose pyridoxine. ( Wood, JP; Yarbrough, BE, 1983) |
| "Isoniazid overdose is a potentially fatal intoxication." | 2.39 | Isoniazid overdose: four case reports and review of the literature. ( Alvarez, FG; Guntupalli, KK, 1995) |
| "Isoniazid (INH) is an integral component of treatment of tuberculosis." | 1.35 | Isoniazid toxicity presenting as status epilepticus and severe metabolic acidosis. ( Gokhale, YA; Mehta, AD; Rathod, NN; Vaidya, MS, 2009) |
| "Pyridoxine was given intravenously as an antidote." | 1.34 | [Isoniazid intoxication]. ( Cyran, J; Graf, J; Radunz, W; Scheffold, N, 2007) |
| "She was in respiratory failure, with seizures that could not be stopped with diazepam." | 1.29 | [Pyridoxine for severe metabolic acidosis and seizures due to isoniazid overdose]. ( Adler, M; Girsh-Solomonovich, Z; Raikhlin-Eisenkraft, B, 1993) |
| "We treated five isoniazid-overdosed patients each with a single dose of pyridoxine hydrochloride equivalent to the gram amount of isoniazid ingested and compared their outcome with that of 41 patients from the literature who received little or no pyridoxine." | 1.26 | Single high-dose pyridoxine treatment for isoniazid overdose. ( Lacouture, PG; Lovejoy, FH; Wason, S, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (55.56) | 18.7374 |
| 1990's | 6 (22.22) | 18.2507 |
| 2000's | 5 (18.52) | 29.6817 |
| 2010's | 1 (3.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Uzman, S | 1 |
| Uludağ Yanaral, T | 1 |
| Toptaş, M | 1 |
| Koç, A | 1 |
| Taş, A | 1 |
| Bican, G | 1 |
| Gokhale, YA | 1 |
| Vaidya, MS | 1 |
| Mehta, AD | 1 |
| Rathod, NN | 1 |
| Caksen, H | 1 |
| Odabas, D | 1 |
| Erol, M | 1 |
| Anlar, O | 1 |
| Tuncer, O | 1 |
| Atas, B | 1 |
| Topcu, I | 1 |
| Yentur, EA | 1 |
| Kefi, A | 1 |
| Ekici, NZ | 1 |
| Sakarya, M | 1 |
| Graf, J | 1 |
| Scheffold, N | 1 |
| Radunz, W | 1 |
| Cyran, J | 1 |
| Pahl, MV | 1 |
| Vaziri, ND | 1 |
| Ness, R | 1 |
| Nathan, R | 1 |
| Maksy, M | 1 |
| Bartlett, K | 1 |
| Yarbrough, BE | 1 |
| Wood, JP | 1 |
| Scarlato, G | 1 |
| Moggio, M | 1 |
| Fici, F | 3 |
| Cerri, C | 1 |
| Belvisi, A | 1 |
| Matergi, M | 1 |
| Wason, S | 1 |
| Lacouture, PG | 1 |
| Lovejoy, FH | 1 |
| Capretti, L | 1 |
| Coscelli, C | 1 |
| Butturini, U | 1 |
| Aggarwal, P | 1 |
| Marcovigi, P | 1 |
| Valtancoli, E | 1 |
| Calbi, P | 1 |
| Farolfi, P | 1 |
| Calbi, G | 1 |
| Adler, M | 1 |
| Girsh-Solomonovich, Z | 1 |
| Raikhlin-Eisenkraft, B | 1 |
| Alvarez, FG | 1 |
| Guntupalli, KK | 1 |
| Temmerman, W | 1 |
| Dhondt, A | 1 |
| Vandewoude, K | 1 |
| Lovecchio, F | 1 |
| Curry, SC | 1 |
| Graeme, KA | 1 |
| Wallace, KL | 1 |
| Suchard, J | 1 |
| Garbin, L | 1 |
| Plebani, M | 1 |
| Terribile, PM | 1 |
| Barzani, G | 1 |
| Liotta, M | 1 |
| Olivieri, M | 1 |
| Tamburini, G | 1 |
| Merli, B | 1 |
| Sievers, ML | 1 |
| Herrier, RN | 1 |
| Watkins, RC | 1 |
| Hambrick, EL | 1 |
| Benjamin, G | 1 |
| Chavda, SN | 1 |
| Köster, B | 1 |
| Bode, U | 1 |
| Weber, HP | 1 |
| Musch, E | 1 |
| Bleandonu, G | 1 |
| Boye, J | 1 |
| Brown, CV | 1 |
| Monchenko, GD | 1 |
| Pruttseva, NV | 1 |
| Friedman, SA | 1 |
3 reviews available for pyridoxine and Acidosis
| Article | Year |
|---|---|
Vitamin-responsive inborn errors of metabolism.
Topics: Acetyl-CoA Carboxylase; Acidosis; Amino Acid Metabolism, Inborn Errors; Animals; Biotin; Folic Acid; | 1983 |
Isoniazid overdose: four case reports and review of the literature.
Topics: Acidosis; Adolescent; Adult; Antitubercular Agents; Drug Overdose; Female; Humans; Isoniazid; Male; | 1995 |
Acute isoniazid intoxication: seizures, acidosis and coma.
Topics: Acidosis; Acute Disease; Adolescent; Antitubercular Agents; Coma; Diagnosis, Differential; Drug Over | 1999 |
2 trials available for pyridoxine and Acidosis
| Article | Year |
|---|---|
Treatment of pyruvic and lactic acidaemia in ophthalmoplegia plus.
Topics: Acidosis; Biopsy; Clinical Trials as Topic; Electromyography; Humans; Lactates; Lactic Acid; Microsc | 1982 |
Intravenous pyridoxine-induced metabolic acidosis.
Topics: Acidosis; Adult; Antidotes; Antitubercular Agents; Blood Gas Analysis; Cross-Over Studies; Drug Moni | 2001 |
22 other studies available for pyridoxine and Acidosis
| Article | Year |
|---|---|
Acute isoniazid intoxication: an uncommon cause of convulsion, coma and acidosis.
Topics: Acidosis; Antitubercular Agents; Coma; Humans; Infusions, Intravenous; Isoniazid; Male; Pyridoxine; | 2013 |
Isoniazid toxicity presenting as status epilepticus and severe metabolic acidosis.
Topics: Acidosis; Adult; Antitubercular Agents; Bicarbonates; Buffers; Diuretics, Osmotic; Female; Humans; I | 2009 |
Do not overlook acute isoniazid poisoning in children with status epilepticus.
Topics: Acidosis; Antitubercular Agents; Child, Preschool; Diagnosis, Differential; Diazepam; Drug Overdose; | 2003 |
Seizures, metabolic acidosis and coma resulting from acute isoniazid intoxication.
Topics: Acidosis; Acute Disease; Adolescent; Anticonvulsants; Antitubercular Agents; Charcoal; Child; Coma; | 2005 |
[Isoniazid intoxication].
Topics: Acidosis; Anticonvulsants; Antidotes; Antitubercular Agents; Diazepam; Female; Humans; Infusions, In | 2007 |
Association of beta hydroxybutyric acidosis with isoniazid intoxication.
Topics: 3-Hydroxybutyric Acid; Acidosis; Adult; Bicarbonates; Diazepam; Female; Humans; Hydroxybutyrates; Is | 1984 |
Isoniazid overdose treated with high-dose pyridoxine.
Topics: Acidosis; Adolescent; Adult; Female; Humans; Isoniazid; Male; Pyridoxine; Seizures | 1983 |
Treatment of hyperlactacidemia in cirrhotic patients with pyridoxine-alpha-ketoglutarate (PAK).
Topics: Acidosis; Adult; Aged; Ammonia; Double-Blind Method; Female; Humans; Lactates; Lactic Acid; Liver Ci | 1982 |
Single high-dose pyridoxine treatment for isoniazid overdose.
Topics: Acidosis; Adolescent; Adult; Bicarbonates; Coma; Female; Humans; Isoniazid; Male; Pyridoxine; Seizur | 1981 |
Pyridoxine-alpha-ketoglutarate in the treatment of experimental lactic acidosis in the rat.
Topics: Acidosis; Animals; Blood Glucose; Lactates; Male; Metformin; Pyridoxine; Rats | 1981 |
INH-induced neurotoxicity.
Topics: Acidosis; Adult; Brain; Drug Overdose; Humans; Isoniazid; Pyridoxine; Seizures | 1994 |
[Pyridoxine administration in acute isoniazid intoxication].
Topics: Acidosis; Blood Gas Analysis; Child, Preschool; Coma; Female; Gastric Lavage; Humans; Isoniazid; Poi | 1993 |
[Pyridoxine for severe metabolic acidosis and seizures due to isoniazid overdose].
Topics: Acidosis; Adolescent; Drug Overdose; Female; Humans; Infusions, Intravenous; Isoniazid; Pyridoxine; | 1993 |
Effect of ACP (pyridoxine-2-oxoglutarate) on CCl4 intoxication and in streptozotocin-induced ketosis in rat.
Topics: Acidosis; Animals; Blood Proteins; Carbon Tetrachloride Poisoning; Ketoglutaric Acids; Ketosis; Male | 1977 |
[Treatment of acetonemic syndromes in children].
Topics: Acidosis; Child; Child, Preschool; Drug Combinations; Drug Evaluation; Female; Humans; Infant; Ketos | 1976 |
Treatment of acute isoniazid toxicity.
Topics: Acidosis; Adolescent; Adult; Airway Obstruction; Anticonvulsants; Bicarbonates; Coma; Diuresis; Fema | 1975 |
Isoniazid toxicity presenting as seizures and metabolic acidosis.
Topics: Acidosis; Adolescent; Humans; Infusions, Intravenous; Isoniazid; Male; Pyridoxine; Seizures | 1990 |
[Acute isoniazid poisoning].
Topics: Acidosis; Coma; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Infant; Isoniazid; Metab | 1985 |
[Neuropsychiatric incidences in antitubercular treatment consisting of isoniazid or isoniazid and ethionamide (8 cases)].
Topics: Acidosis; Adult; Alcoholism; Ammonia; Avitaminosis; Carboxy-Lyases; Chromatography, Paper; Chromatog | 1969 |
Acute isoniazid poisoning.
Topics: Acidosis; Acute Disease; Adolescent; Adult; Aged; Alaska; Antidotes; Carbon Dioxide; Child; Child, P | 1972 |
[Efficacy of preoperative correction of metabolic acidosis with neoplastic processes in different sites].
Topics: Acidosis; Adult; Aged; Ascorbic Acid; Female; Glucose; Humans; Insulin; Intestinal Neoplasms; Lung N | 1971 |
Death following massive ingestion of isoniazid.
Topics: Acidosis; Adolescent; Anticonvulsants; Coma; Fever; Gastric Lavage; Humans; Intubation, Intratrachea | 1969 |