pyridoxine has been researched along with Absence Status in 28 studies
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective of this study was to determine the prevalence of pyridoxine deficiency, measured by pyridoxal phosphate (PLP) levels, in patients admitted to the hospital with established (benzodiazepine-resistant) status epilepticus (SE) (eSE) and to compare to three control groups: intensive care unit (ICU) patients without SE (ICU-noSE), non-ICU inpatients without SE (non-ICU), and outpatients with or without a history of epilepsy (outpatient)." | 8.31 | Association of Serum Pyridoxal Phosphate Levels with Established Status Epilepticus. ( Blodgett, C; Boudesseul, J; Bruzzone, MJ; Hianik, R; Hirsch, LJ; Jadav, R; Liu, C; Meeker, R; Olm-Shipman, C; Patel, P; Rubinos, C; Tsai, C; Wilson, SE; Zhu, H, 2023) |
| "Pyridoxine-dependent epilepsy (PDE) is a genetic metabolic disease caused by inborn errors affecting vitamin B6 metabolism, which typically presents with neonatal seizures resistant to antiepileptic drugs (AEDs)." | 7.96 | Diagnosis of pyridoxine-dependent epilepsy in an adult presenting with recurrent status epilepticus. ( Foulds, N; Hunt, D; Jade Edwards, C; Osman, C; Prevett, M, 2020) |
| "An 8-year-old girl treated at our facility for superrefractory status epilepticus was found to have a low pyridoxine level at 5 μg/L." | 7.81 | Pyridoxine deficiency in adult patients with status epilepticus. ( Dave, HN; Eugene Ramsay, R; Irland, M; Khan, F; Sabharwal, V, 2015) |
| "Pyridoxine-dependent epilepsy (PDE) is a treatable inborn error of metabolism with autosomal recessive inheritance." | 7.77 | Status epilepticus in a neonate treated with pyridoxine because of a familial recurrence risk for antiquitin deficiency: pyridoxine toxicity? ( Fingerhut, M; Hartmann, H; Jakobs, C; Plecko, B, 2011) |
| "Pyridoxine-dependent epilepsy usually presents in the neonatal period or even in utero, is refractory to antiepileptic medications, and is treatable with lifelong administration of pyridoxine." | 7.73 | Focal status epilepticus as atypical presentation of pyridoxine-dependent epilepsy. ( Kelly, PJ; Krishnamoorthy, KS; Takeoka, M; Yoshii, A, 2005) |
| "Isoniazid (INH) is an effective treatment for tuberculosis and among the most common causes of drug-induced seizures in the United States." | 5.36 | Isoniazid-induced status epilepticus in a pediatric patient after inadequate pyridoxine therapy. ( Clark, RF; Ghafouri, N; Minns, AB, 2010) |
| "Isoniazid (INH) is an integral component of treatment of tuberculosis." | 5.35 | Isoniazid toxicity presenting as status epilepticus and severe metabolic acidosis. ( Gokhale, YA; Mehta, AD; Rathod, NN; Vaidya, MS, 2009) |
| "Mexiletine is a group Ib antidysrhythmic agent with electrophysiologic effects similar to lidocaine." | 5.29 | Mexiletine overdose producing status epilepticus without cardiovascular abnormalities. ( Hoffman, RS; Nelson, LS, 1994) |
| "The objective of this study was to determine the prevalence of pyridoxine deficiency, measured by pyridoxal phosphate (PLP) levels, in patients admitted to the hospital with established (benzodiazepine-resistant) status epilepticus (SE) (eSE) and to compare to three control groups: intensive care unit (ICU) patients without SE (ICU-noSE), non-ICU inpatients without SE (non-ICU), and outpatients with or without a history of epilepsy (outpatient)." | 4.31 | Association of Serum Pyridoxal Phosphate Levels with Established Status Epilepticus. ( Blodgett, C; Boudesseul, J; Bruzzone, MJ; Hianik, R; Hirsch, LJ; Jadav, R; Liu, C; Meeker, R; Olm-Shipman, C; Patel, P; Rubinos, C; Tsai, C; Wilson, SE; Zhu, H, 2023) |
| "Hypophosphatasia (HPP), an inherited, metabolic disorder caused by loss-of-function mutations in the ALPL gene, affects not only bone and tooth mineralization but also central nervous system (CNS) function, resulting in vitamin B6/pyridoxine-responsive seizures." | 4.12 | Status Epilepticus due to Asfotase Alfa Interruption in Perinatal Severe Hypophosphatasia. ( Miyama, S; Ogawa, E; Shimura, K; Yoshihashi, H, 2022) |
| "Pyridoxine-dependent epilepsy (PDE) is a genetic metabolic disease caused by inborn errors affecting vitamin B6 metabolism, which typically presents with neonatal seizures resistant to antiepileptic drugs (AEDs)." | 3.96 | Diagnosis of pyridoxine-dependent epilepsy in an adult presenting with recurrent status epilepticus. ( Foulds, N; Hunt, D; Jade Edwards, C; Osman, C; Prevett, M, 2020) |
| "An 8-year-old girl treated at our facility for superrefractory status epilepticus was found to have a low pyridoxine level at 5 μg/L." | 3.81 | Pyridoxine deficiency in adult patients with status epilepticus. ( Dave, HN; Eugene Ramsay, R; Irland, M; Khan, F; Sabharwal, V, 2015) |
| "To determine whether patients with pyridoxine-responsive seizures but normal biomarkers for antiquitin deficiency and normal sequencing of the ALDH7A1 gene may have PNPO mutations." | 3.80 | Pyridoxine responsiveness in novel mutations of the PNPO gene. ( Abela, L; Clayton, P; Connolly, M; Hasselmann, O; Hofer, D; Kanz, S; Maier, O; Mills, P; Paschke, E; Paul, K; Plecko, B; Schmiedel, G; Stockler, S; Struys, E; Wolf, N, 2014) |
| "Pyridoxine-dependent epilepsy (PDE) is a treatable inborn error of metabolism with autosomal recessive inheritance." | 3.77 | Status epilepticus in a neonate treated with pyridoxine because of a familial recurrence risk for antiquitin deficiency: pyridoxine toxicity? ( Fingerhut, M; Hartmann, H; Jakobs, C; Plecko, B, 2011) |
| "Pyridoxine-dependent epilepsy usually presents in the neonatal period or even in utero, is refractory to antiepileptic medications, and is treatable with lifelong administration of pyridoxine." | 3.73 | Focal status epilepticus as atypical presentation of pyridoxine-dependent epilepsy. ( Kelly, PJ; Krishnamoorthy, KS; Takeoka, M; Yoshii, A, 2005) |
| "A 25-year-old, 54-kg Hispanic man who had recently started multidrug therapy for pulmonary tuberculosis presented in status epilepticus after ingesting 9 g of isoniazid in a suicide attempt." | 3.73 | Acute isoniazid toxicity and the need for adequate pyridoxine supplies. ( Malesker, M; Morrow, LE; Schuller, D; Wear, RE, 2006) |
| "An 11-year-old male with autism became less responsive and was hospitalized with hepatomegaly and liver dysfunction, as well as severe lactic acidosis." | 1.42 | Vitamin B deficiencies in a critically ill autistic child with a restricted diet. ( Baird, JS; Ravindranath, TM, 2015) |
| "Isoniazid (INH) is an effective treatment for tuberculosis and among the most common causes of drug-induced seizures in the United States." | 1.36 | Isoniazid-induced status epilepticus in a pediatric patient after inadequate pyridoxine therapy. ( Clark, RF; Ghafouri, N; Minns, AB, 2010) |
| "Epileptic seizures due to pyridoxine deficiency, although rare, are known to occur." | 1.35 | Epileptic status refractory to conventional treatment caused by vitamin B6 deficiency. ( Barber, M; Cortés-Cros, E; Figueras, T; García-Hernández, JA; Santana, A; Valle-Morales, L, 2009) |
| "Isoniazid (INH) is an integral component of treatment of tuberculosis." | 1.35 | Isoniazid toxicity presenting as status epilepticus and severe metabolic acidosis. ( Gokhale, YA; Mehta, AD; Rathod, NN; Vaidya, MS, 2009) |
| "Mexiletine is a group Ib antidysrhythmic agent with electrophysiologic effects similar to lidocaine." | 1.29 | Mexiletine overdose producing status epilepticus without cardiovascular abnormalities. ( Hoffman, RS; Nelson, LS, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (10.71) | 18.7374 |
| 1990's | 4 (14.29) | 18.2507 |
| 2000's | 9 (32.14) | 29.6817 |
| 2010's | 9 (32.14) | 24.3611 |
| 2020's | 3 (10.71) | 2.80 |
| Authors | Studies |
|---|---|
| Ogawa, E | 1 |
| Shimura, K | 1 |
| Yoshihashi, H | 1 |
| Miyama, S | 1 |
| Rubinos, C | 1 |
| Bruzzone, MJ | 1 |
| Blodgett, C | 1 |
| Tsai, C | 1 |
| Patel, P | 1 |
| Hianik, R | 1 |
| Jadav, R | 1 |
| Boudesseul, J | 1 |
| Liu, C | 1 |
| Zhu, H | 1 |
| Wilson, SE | 1 |
| Olm-Shipman, C | 1 |
| Meeker, R | 1 |
| Hirsch, LJ | 1 |
| Osman, C | 1 |
| Foulds, N | 1 |
| Hunt, D | 1 |
| Jade Edwards, C | 1 |
| Prevett, M | 1 |
| Vidaurre, J | 1 |
| Nunley, S | 1 |
| Yang, ZX | 1 |
| Qin, J | 1 |
| Plecko, B | 3 |
| Paul, K | 2 |
| Mills, P | 1 |
| Clayton, P | 1 |
| Paschke, E | 2 |
| Maier, O | 1 |
| Hasselmann, O | 1 |
| Schmiedel, G | 1 |
| Kanz, S | 1 |
| Connolly, M | 1 |
| Wolf, N | 1 |
| Struys, E | 1 |
| Stockler, S | 1 |
| Abela, L | 1 |
| Hofer, D | 1 |
| Baird, JS | 1 |
| Ravindranath, TM | 1 |
| Dave, HN | 1 |
| Eugene Ramsay, R | 1 |
| Khan, F | 1 |
| Sabharwal, V | 1 |
| Irland, M | 1 |
| Valle-Morales, L | 1 |
| Cortés-Cros, E | 1 |
| Santana, A | 1 |
| Barber, M | 1 |
| Figueras, T | 1 |
| García-Hernández, JA | 1 |
| Kluger, G | 1 |
| Blank, R | 1 |
| Jansen, E | 1 |
| Jakobs, C | 2 |
| Wörle, H | 1 |
| Gokhale, YA | 1 |
| Vaidya, MS | 1 |
| Mehta, AD | 1 |
| Rathod, NN | 1 |
| Tabarki, B | 1 |
| Thabet, F | 1 |
| Naasan, G | 1 |
| Yabroudi, M | 1 |
| Rahi, A | 1 |
| Mikati, MA | 1 |
| Minns, AB | 1 |
| Ghafouri, N | 1 |
| Clark, RF | 1 |
| Zell-Kanter, M | 1 |
| Hartmann, H | 1 |
| Fingerhut, M | 1 |
| Caksen, H | 1 |
| Odabas, D | 1 |
| Erol, M | 1 |
| Anlar, O | 1 |
| Tuncer, O | 1 |
| Atas, B | 1 |
| Schulze-Bonhage, A | 1 |
| Kurthen, M | 1 |
| Walger, P | 1 |
| Elger, CE | 1 |
| Yoshii, A | 1 |
| Takeoka, M | 1 |
| Kelly, PJ | 1 |
| Krishnamoorthy, KS | 1 |
| Morrow, LE | 1 |
| Wear, RE | 1 |
| Schuller, D | 1 |
| Malesker, M | 1 |
| Kim, JE | 1 |
| Kim, DW | 1 |
| Kwak, SE | 1 |
| Kwon, OS | 1 |
| Choi, SY | 1 |
| Kang, TC | 1 |
| Lockard, JS | 1 |
| Levy, RH | 1 |
| Koch, KM | 1 |
| Maris, DO | 1 |
| Friel, PN | 1 |
| Johnson, GM | 1 |
| Nelson, LS | 2 |
| Hoffman, RS | 2 |
| Rella, J | 1 |
| Yoshikawa, H | 1 |
| Abe, T | 1 |
| Oda, Y | 1 |
| Connolly, MB | 1 |
| Jan, JE | 1 |
| Junker, AK | 1 |
| Goutières, F | 1 |
| Aicardi, J | 1 |
2 reviews available for pyridoxine and Absence Status
| Article | Year |
|---|---|
[Advances in clinical and molecular genetic research on pyridoxine dependent epilepsy].
Topics: 2-Aminoadipic Acid; Aldehyde Dehydrogenase; Anticonvulsants; Biomarkers; Brain; DNA Mutational Analy | 2013 |
Pyridoxine-dependent seizures in an older child.
Topics: Child; Child, Preschool; Electroencephalography; Female; Follow-Up Studies; Humans; Infant; Infant, | 1999 |
26 other studies available for pyridoxine and Absence Status
| Article | Year |
|---|---|
Status Epilepticus due to Asfotase Alfa Interruption in Perinatal Severe Hypophosphatasia.
Topics: Alkaline Phosphatase; Enzyme Replacement Therapy; Female; Humans; Hypophosphatasia; Immunoglobulin G | 2022 |
Association of Serum Pyridoxal Phosphate Levels with Established Status Epilepticus.
Topics: Adult; Aged; Aged, 80 and over; Humans; Middle Aged; Prospective Studies; Pyridoxal; Pyridoxal Phosp | 2023 |
Diagnosis of pyridoxine-dependent epilepsy in an adult presenting with recurrent status epilepticus.
Topics: Adolescent; Age of Onset; Aldehyde Dehydrogenase; Epilepsy; Female; Humans; Mutation; Pyridoxine; St | 2020 |
Atypical Presentation of a Progressive and Treatable Encephalopathy in an Older Child With Gelastic and Dacrystic Seizures.
Topics: Adolescent; Anticonvulsants; Brain; Diagnosis, Differential; Disease Progression; Epilepsies, Partia | 2018 |
Pyridoxine responsiveness in novel mutations of the PNPO gene.
Topics: Aldehyde Dehydrogenase; Alleles; Animals; Brain Diseases, Metabolic; CHO Cells; Chromosome Deletion; | 2014 |
Vitamin B deficiencies in a critically ill autistic child with a restricted diet.
Topics: Acidosis, Lactic; Autistic Disorder; Child; Critical Illness; Diet; Fast Foods; Feeding Behavior; He | 2015 |
Pyridoxine deficiency in adult patients with status epilepticus.
Topics: Adult; Child; Electroencephalography; Female; gamma-Aminobutyric Acid; Humans; Pyridoxine; Seizures; | 2015 |
Epileptic status refractory to conventional treatment caused by vitamin B6 deficiency.
Topics: Adult; Female; Humans; Infusions, Intravenous; Pregnancy; Pyridoxine; Status Epilepticus; Vitamin B | 2009 |
Pyridoxine-dependent epilepsy: normal outcome in a patient with late diagnosis after prolonged status epilepticus causing cortical blindness.
Topics: Adolescent; Aldehyde Dehydrogenase; Alleles; Anticonvulsants; Blindness, Cortical; Child; Child, Pre | 2008 |
Isoniazid toxicity presenting as status epilepticus and severe metabolic acidosis.
Topics: Acidosis; Adult; Antitubercular Agents; Bicarbonates; Buffers; Diuretics, Osmotic; Female; Humans; I | 2009 |
[Prolonged electrocerebral depression after oral administration of pyridoxine for pyridoxine-dependent convulsions].
Topics: Administration, Oral; Aldehyde Dehydrogenase; Anticonvulsants; Brain Death; Chromosome Aberrations; | 2010 |
Electroencephalographic changes in pyridoxine-dependant epilepsy: new observations.
Topics: Age of Onset; Electroencephalography; Epilepsies, Partial; Epilepsy, Generalized; Epilepsy, Tonic-Cl | 2009 |
Isoniazid-induced status epilepticus in a pediatric patient after inadequate pyridoxine therapy.
Topics: Antitubercular Agents; Diagnosis, Differential; Dose-Response Relationship, Drug; Drug Overdose; Hum | 2010 |
Oral pyridoxine in the management of isoniazid poisoning.
Topics: Administration, Oral; Antidotes; Humans; Intubation, Gastrointestinal; Isoniazid; Pyridoxine; Status | 2010 |
Status epilepticus in a neonate treated with pyridoxine because of a familial recurrence risk for antiquitin deficiency: pyridoxine toxicity?
Topics: Adult; Aldehyde Dehydrogenase; Epilepsy; Female; Humans; Infant; Infant, Newborn; Infusions, Parente | 2011 |
Do not overlook acute isoniazid poisoning in children with status epilepticus.
Topics: Acidosis; Antitubercular Agents; Child, Preschool; Diagnosis, Differential; Diazepam; Drug Overdose; | 2003 |
Pharmacorefractory status epilepticus due to low vitamin B6 levels during pregnancy.
Topics: Adult; Electroencephalography; Female; Humans; Pregnancy; Pyridoxine; Status Epilepticus; Vitamin B | 2004 |
Focal status epilepticus as atypical presentation of pyridoxine-dependent epilepsy.
Topics: Diagnosis, Differential; Electroencephalography; Epilepsy; Female; Humans; Infant; Pyridoxine; Statu | 2005 |
Acute isoniazid toxicity and the need for adequate pyridoxine supplies.
Topics: Acute Disease; Adult; Antidotes; Antitubercular Agents; Drug Overdose; Drugs, Essential; Humans; Inf | 2006 |
Potential role of pyridoxal-5'-phosphate phosphatase/chronopin in epilepsy.
Topics: Actin Cytoskeleton; Actin Depolymerizing Factors; Animals; Cloning, Molecular; Disease Models, Anima | 2008 |
A monkey model for status epilepticus: carbamazepine and valproate compared to three standard anticonvulsants.
Topics: Aluminum Hydroxide; Animals; Anticonvulsants; Carbamazepine; Diazepam; Macaca mulatta; Male; Phenoba | 1983 |
Powdered goat's milk: pyridoxine deficiency and status epilepticus.
Topics: Animals; Goats; Humans; Infant; Infant Food; Injections, Intramuscular; Male; Milk; Powders; Pyridox | 1982 |
Mexiletine overdose producing status epilepticus without cardiovascular abnormalities.
Topics: Adult; Blood Pressure; Cardiovascular System; Diazepam; Drug Overdose; Drug Therapy, Combination; El | 1994 |
Status epilepticus.
Topics: Drug Overdose; Humans; Isoniazid; Pyridoxine; Status Epilepticus | 1998 |
Intravenous immunoglobulin and pyridoxine-dependent seizures.
Topics: Child, Preschool; Humans; Immunization, Passive; Male; Pyridoxine; Seizures; Status Epilepticus | 1991 |
Atypical presentations of pyridoxine-dependent seizures: a treatable cause of intractable epilepsy in infants.
Topics: Child, Preschool; Electroencephalography; Epilepsy; Female; Humans; Infant; Male; Pyridoxine; Status | 1985 |