pyridoxine has been researched along with Abnormalities, Drug-Induced in 107 studies
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol: structure in first source
vitamin B6 : Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Doxylamine-pyridoxine is the first-line agent for the treatment of nausea and vomiting of pregnancy (NVP) according to Canadian guidelines, and this combination is commonly prescribed to pregnant women." | 7.80 | Should doxylamine-pyridoxine be used for nausea and vomiting of pregnancy? ( Chin, J; Persaud, N; Walker, M, 2014) |
| " The pregnancy was complicated by chronic maternal schizophrenia, severe toxaemia and maternal use of fluphenazine enanthate, dicyclomine hydrochloride, doxylamine succinate, pyridoxine hydrochloride and other drugs." | 7.66 | Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy. ( Bury, RG; Donaldson, GL, 1982) |
| "Administration of Vitamin B6 during gestation to mice on a Vitamin B6-containing diet resulted in a substantial reduction in cortisone-induced cleft palate." | 7.66 | Vitamin B6 reduces cortisone-induced cleft palate in the mouse. ( Pratt, RM; Yoneda, T, 1982) |
| " We used as a motivating example the possible teratogenic risks of antiemetic agents in pregnancy since a large observational study recently showed that first-trimester exposure to doxylamine-pyridoxine was associated with significantly increased risk of congenital malformations as a whole, as well as central nervous system defects, and previous observational studies did not show such associations." | 5.12 | Misleading meta-analyses of observational studies may generate unjustified alarms: The case of medications for nausea and vomiting in pregnancy. ( Biffi, A; Cetin, I; Corrao, G; Filippelli, A; Locatelli, A; Rea, F, 2021) |
| ""Bendectin" (Doxylamine/Dicyclomine/Pyridoxine) was widely used for the treatment of nausea and vomiting of pregnancy until 1983, when production was discontinued in the face of lawsuits alleging that the drug caused congenital malformations." | 4.79 | Bendectin and birth defects: I. A meta-analysis of the epidemiologic studies. ( Kutcher, JS; Lamm, SH; Linn, S; McKeigue, PM, 1994) |
| " The only well-established human vitamin neurotoxic effects are those due to hypervitaminosis A (pseudotumor cerebri) and pyridoxine (sensory neuropathy)." | 4.78 | Vitamin neurotoxicity. ( Snodgrass, SR, 1992) |
| "Using the Quebec Pregnancy Cohort (1998-2015), first-trimester doxylamine-pyridoxine, metoclopramide, and ondansetron exposures were assessed for their association with MCM." | 3.91 | New evidence for concern over the risk of birth defects from medications for nausea and vomitting of pregnancy. ( Bérard, A; Bernatsky, S; Gorgui, J; Sheehy, O; Soares de Moura, C; Zhao, JP, 2019) |
| "Doxylamine-pyridoxine is the first-line agent for the treatment of nausea and vomiting of pregnancy (NVP) according to Canadian guidelines, and this combination is commonly prescribed to pregnant women." | 3.80 | Should doxylamine-pyridoxine be used for nausea and vomiting of pregnancy? ( Chin, J; Persaud, N; Walker, M, 2014) |
| "The antinausea drug combination, doxylamine/dicyclomine/pyridoxine (Debendox or Bendectin [US] ), has been withdrawn from the market because of litigation based upon charges that it causes congenital limb defects." | 3.67 | The innocent bystander. Doxylamine/dicyclomine/pyridoxine and congenital limb defects. ( Elliott, J; Forrest, J; Kricker, A; McCredie, J, 1984) |
| "Bendectin, composed of doxylamine succinate and pyridoxine HCl (1:1), is an antinauseant previously prescribed for nausea and vomiting during pregnancy." | 3.67 | Developmental toxicity evaluation of Bendectin in CD rats. ( Kimmel, CA; Marr, MC; Price, CJ; Tyl, RW, 1988) |
| " The pregnancy was complicated by chronic maternal schizophrenia, severe toxaemia and maternal use of fluphenazine enanthate, dicyclomine hydrochloride, doxylamine succinate, pyridoxine hydrochloride and other drugs." | 3.66 | Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy. ( Bury, RG; Donaldson, GL, 1982) |
| "Administration of Vitamin B6 during gestation to mice on a Vitamin B6-containing diet resulted in a substantial reduction in cortisone-induced cleft palate." | 3.66 | Vitamin B6 reduces cortisone-induced cleft palate in the mouse. ( Pratt, RM; Yoneda, T, 1982) |
| "A literature review was conducted on adverse effects associated with administration of high oral doses of pyridoxine (vitamin B6) to animals and man." | 2.37 | Safety of pyridoxine--a review of human and animal studies. ( Bendich, A; Cohen, M, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 77 (71.96) | 18.7374 |
| 1990's | 20 (18.69) | 18.2507 |
| 2000's | 4 (3.74) | 29.6817 |
| 2010's | 5 (4.67) | 24.3611 |
| 2020's | 1 (0.93) | 2.80 |
| Authors | Studies |
|---|---|
| Biffi, A | 1 |
| Rea, F | 1 |
| Locatelli, A | 1 |
| Cetin, I | 1 |
| Filippelli, A | 1 |
| Corrao, G | 1 |
| Bérard, A | 1 |
| Sheehy, O | 1 |
| Gorgui, J | 1 |
| Zhao, JP | 1 |
| Soares de Moura, C | 1 |
| Bernatsky, S | 1 |
| Howland, RH | 1 |
| Persaud, N | 2 |
| Chin, J | 1 |
| Walker, M | 1 |
| Tauqeer, S | 1 |
| Khan, RA | 1 |
| Siddiqui, AA | 1 |
| Healy, D | 1 |
| Brent, R | 2 |
| Kutcher, JS | 2 |
| Engle, A | 1 |
| Firth, J | 1 |
| Lamm, SH | 2 |
| HARLEY, JD | 1 |
| FARRAR, JF | 1 |
| Brickley, P | 1 |
| Clarke, M | 1 |
| Clayton, DG | 1 |
| Hall, JB | 1 |
| Smithells, RW | 2 |
| Sheppard, S | 2 |
| Kalter, H | 1 |
| Warkany, J | 1 |
| Holmes, LB | 1 |
| Patterson, SP | 1 |
| Hill, LM | 1 |
| Kleinberg, F | 1 |
| Cordero, JF | 2 |
| Oakley, GP | 2 |
| Grodofsky, MP | 1 |
| Wilmott, RW | 1 |
| Leeder, JS | 1 |
| Spielberg, SP | 1 |
| MacLeod, SM | 1 |
| Mitchell, AA | 1 |
| Schwingl, PJ | 1 |
| Rosenberg, L | 1 |
| Louik, C | 1 |
| Shapiro, S | 1 |
| Aselton, PJ | 1 |
| Jick, H | 3 |
| McCredie, J | 1 |
| Kricker, A | 1 |
| Elliott, J | 1 |
| Forrest, J | 1 |
| Davis, JM | 1 |
| Correy, JF | 3 |
| Newman, NM | 3 |
| Niebyl, JR | 1 |
| Shanks, RG | 2 |
| Griffiths, K | 2 |
| Harron, DW | 2 |
| Fleming, DM | 1 |
| Knox, JD | 1 |
| Crombie, DL | 1 |
| Michaelis, J | 1 |
| Michaelis, H | 1 |
| Glück, E | 1 |
| Koller, S | 1 |
| Brent, RR | 1 |
| Brown, A | 1 |
| Leal, J | 1 |
| Huff, PS | 1 |
| Kolata, G | 2 |
| Morelock, S | 1 |
| Hingson, R | 1 |
| Kayne, H | 1 |
| Dooling, E | 1 |
| Zuckerman, B | 1 |
| Day, N | 1 |
| Alpert, JJ | 1 |
| Flowerdew, G | 1 |
| Gart, JJ | 1 |
| Thomas, DG | 1 |
| David, TJ | 1 |
| Donaldson, GL | 1 |
| Bury, RG | 1 |
| Eskenazi, B | 1 |
| Bracken, MB | 1 |
| Yoneda, T | 1 |
| Pratt, RM | 1 |
| Greenberg, F | 1 |
| James, LM | 1 |
| Gibson, GT | 1 |
| Colley, DP | 1 |
| McMichael, AJ | 1 |
| Hartshorne, JM | 1 |
| Kolata, GB | 1 |
| Korcok, M | 1 |
| Pearson, RD | 1 |
| Barinaga, M | 1 |
| McKeigue, PM | 1 |
| Linn, S | 1 |
| Appelbaum, PS | 1 |
| Bertin, JE | 1 |
| Henifin, MS | 1 |
| Brushwood, DB | 1 |
| McBride, WG | 2 |
| Mervis, J | 1 |
| Marwick, C | 1 |
| Marshall, E | 1 |
| Koren, G | 1 |
| Pastuszak, A | 1 |
| Ito, S | 1 |
| Sanders, J | 1 |
| Jackson, KA | 1 |
| Jaffe, P | 1 |
| Liberman, MM | 1 |
| McFadyen, I | 1 |
| Valman, HB | 1 |
| Check, WA | 1 |
| Milkovich, L | 1 |
| van den Berg, BJ | 1 |
| Patterson, DC | 1 |
| Khera, KS | 1 |
| Brannigan, VM | 1 |
| Bier, VM | 1 |
| Berg, C | 1 |
| Snodgrass, SR | 1 |
| Elmazar, MM | 1 |
| Thiel, R | 1 |
| Nau, H | 1 |
| Dostal, M | 1 |
| Schubert, J | 1 |
| Bendich, A | 2 |
| Cohen, M | 2 |
| Saunders, EJ | 1 |
| Saunders, JA | 1 |
| Newman, SA | 1 |
| Shiono, PH | 1 |
| Klebanoff, MA | 1 |
| Kiley, VA | 1 |
| Lazerson, J | 1 |
| Tyl, RW | 1 |
| Price, CJ | 1 |
| Marr, MC | 1 |
| Kimmel, CA | 1 |
| Goldberg, JD | 1 |
| Golbus, MS | 1 |
| Elbourne, D | 2 |
| Mutch, L | 2 |
| Melnick, M | 1 |
| Porter, JB | 1 |
| Hunter-Mitchell, J | 1 |
| Walker, AM | 1 |
| Sheffield, LJ | 1 |
| Batagol, R | 1 |
| Orme, ML | 1 |
| Aselton, P | 1 |
| Milunsky, A | 1 |
| Hunter, JR | 1 |
| Stergachis, A | 1 |
| Brent, RL | 1 |
| Danks, DM | 1 |
| Dauncey, M | 1 |
| Campbell, H | 1 |
| Samphier, M | 1 |
| Gibson, JP | 1 |
| Staples, RE | 1 |
| Larson, EJ | 1 |
| Kuhn, WL | 1 |
| Holtkamp, DE | 1 |
| Newberne, JW | 1 |
| Miller, TJ | 1 |
| Castellano, MA | 1 |
| Tórtora, JL | 1 |
| Germino, NI | 1 |
| Rama, F | 1 |
| Ohanian, C | 1 |
| Copeman, PW | 1 |
| Zucconi, G | 1 |
| Pannuti, P | 1 |
| Conti, G | 1 |
| Milio, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prevalence and Burden of Nausea and Vomiting in Pregnant Women in Switzerland: Survey Purity 2022[NCT06055192] | 200 participants (Anticipated) | Observational | 2023-09-30 | Not yet recruiting | |||
| A Study of the Pharmacology of 17-Hydroxyprogesterone Caproate in Pregnancy[NCT00409825] | Phase 2 | 61 participants (Actual) | Interventional | 2006-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Change in the area under the concentration vs. time curve in the second and third trimesters of pregnancy.~We compared AUC at each PK study visit. Measurements were obtained at 0, 1, 2, 3, 4, 5, 6, 7 days." (NCT00409825)
Timeframe: Second and third trimesters of pregnancy
| Intervention | ng/ML/day (Mean) | |
|---|---|---|
| AUC -1 | AUC - 2 | |
| Part 1 | 115 | 136 |
15 reviews available for pyridoxine and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Misleading meta-analyses of observational studies may generate unjustified alarms: The case of medications for nausea and vomiting in pregnancy.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 2021 |
Congenital malformations (second of two parts).
Topics: Abnormalities, Drug-Induced; Air Pollutants, Occupational; Alcohol Drinking; Anesthetics; Anticoagul | 1983 |
Teratogen update: bendectin.
Topics: Abnormalities, Drug-Induced; Animals; Dicyclomine; Doxylamine; Drug Combinations; Drug Utilization; | 1983 |
Effects of drugs and chemicals on the fetus and newborn (1).
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Behavior; Caffeine; Dicyclomine; Doxylamine; Drug | 1984 |
Drug exposure during pregnancy: some epidemiologic considerations.
Topics: Abnormalities, Drug-Induced; Benzodiazepines; Caffeine; Dicyclomine; Doxylamine; Drug Combinations; | 1983 |
Safety of drug therapy for nausea and vomiting of pregnancy.
Topics: Abnormalities, Drug-Induced; Antiemetics; Child; Dicyclomine; Doxylamine; Drug Combinations; Female; | 1980 |
Bendectin and birth defects: I. A meta-analysis of the epidemiologic studies.
Topics: Abnormalities, Drug-Induced; Antiemetics; Case-Control Studies; Cohort Studies; Dicyclomine; Doxylam | 1994 |
Drugs in pregnancy.
Topics: Abnormalities, Drug-Induced; Animals; Counseling; Dicyclomine; Doxylamine; Drug Combinations; Drug E | 1998 |
Medical, social, and legal implications of treating nausea and vomiting of pregnancy.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 2002 |
Vitamin neurotoxicity.
Topics: Abnormalities, Drug-Induced; Animals; Ascorbic Acid; Avitaminosis; Blood-Brain Barrier; Carrier Prot | 1992 |
Vitamin B6 safety issues.
Topics: Abnormalities, Drug-Induced; Animals; Humans; Nervous System Diseases; Pyridoxine | 1990 |
Drug therapy in pregnancy: the lessons of diethylstilbestrol, thalidomide, and bendectin.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Diethylstilbestrol; Doxylamine; Drug Combinat | 1990 |
Safety of pyridoxine--a review of human and animal studies.
Topics: Abnormalities, Drug-Induced; Animals; Dose-Response Relationship, Drug; Female; Humans; Nervous Syst | 1986 |
The creation of therapeutic orphans--or, what have we learnt from the Debendox fiasco?
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Australia; Clinical Trials as Topic; Cyclohexanec | 1985 |
Chloroquine.
Topics: Abnormalities, Drug-Induced; Animals; Ascorbic Acid; Child; Chloroquine; Enzymes; Eye Diseases; Fema | 1967 |
3 trials available for pyridoxine and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
FDA to reexamine bendectin data.
Topics: Abnormalities, Drug-Induced; Animals; Clinical Trials as Topic; Dicyclomine; Doxylamine; Drug Combin | 1982 |
An evaluation of the teratogenicity of certain antinauseant drugs.
Topics: Abnormalities, Drug-Induced; Antiemetics; Clinical Trials as Topic; Cyclizine; Dicyclomine; Doxylami | 1976 |
The creation of therapeutic orphans--or, what have we learnt from the Debendox fiasco?
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Australia; Clinical Trials as Topic; Cyclohexanec | 1985 |
90 other studies available for pyridoxine and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
New evidence for concern over the risk of birth defects from medications for nausea and vomitting of pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Antiemetics; Cohort Studies; Dicyclomine; Doxylamine; Drug Combi | 2019 |
Concern for truth: driving defensively when confronting a zombie epidemic.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Histor | 2013 |
Should doxylamine-pyridoxine be used for nausea and vomiting of pregnancy?
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 2014 |
Evaluation of teratogenic effects of risperidone following simultaneous administration with antihypertensive and antiemetic drugs.
Topics: Abnormalities, Drug-Induced; alpha-Tocopherol; Animals; Antiemetics; Antihypertensive Agents; Drug E | 2012 |
Epidemiological evidence in forensic pharmacovigilance.
Topics: Abnormalities, Drug-Induced; Antiemetics; Breast Implantation; Causality; Connective Tissue Diseases | 2012 |
Bendectin and birth defects: hopefully, the final chapter.
Topics: Abnormalities, Drug-Induced; Adult; Adverse Drug Reaction Reporting Systems; Animals; Antiemetics; C | 2003 |
Bendectin and birth defects. II: Ecological analyses.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Adverse Drug Reaction Reporting Systems | 2003 |
MATERNAL DRUG THERAPY AND CONGENITAL CATARACTS.
Topics: Abnormalities, Drug-Induced; Analgesics; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Antipyreti | 1964 |
Science v. law. A decade-old rule on scientific evidence comes under fire.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Drug Industry; Expert Testi | 2003 |
Safety of Debendox.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Fetal Death; Humans | 1981 |
Debendox in pregnancy.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Fetus; Humans; Infa | 1981 |
Teratogenicity of debendox and pyrimethamine.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Pregnancy; | 1983 |
Debendox is not thalidomide.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 1984 |
Our bundle of responsibility. Presidential address.
Topics: Abnormalities, Drug-Induced; Costs and Cost Analysis; Delivery of Health Care; Dicyclomine; Doxylami | 1984 |
Possible association of use of bendectin during early pregnancy and congenital lung hypoplasia.
Topics: Abnormalities, Drug-Induced; Adult; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; | 1984 |
Debendox and pregnancy.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Nausea; Pre | 1984 |
Bendectin: the wrong way to regulate drug availability.
Topics: Abnormalities, Drug-Induced; Canada; Dicyclomine; Doxylamine; Drug Combinations; Drug Industry; Fema | 1983 |
Birth defects in relation to Bendectin use in pregnancy. II. Pyloric stenosis.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Hyperemesis | 1983 |
Additional follow-up of congenital limb disorders in relation to Bendectin use.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Follow | 1983 |
The innocent bystander. Doxylamine/dicyclomine/pyridoxine and congenital limb defects.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Dose-Response Relationship, Drug; Doxylamine; | 1984 |
Good-bye, Bendectin, old friend.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Drug Industry; Female; Huma | 1984 |
Debendox withdrawn.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Infant, New | 1984 |
Therapeutic drugs in pregnancy. Caution is the watchword.
Topics: Abnormalities, Drug-Induced; Analgesics; Anti-Bacterial Agents; Anti-Infective Agents; Anticonvulsan | 1984 |
Debendox and congenital malformations in Northern Ireland.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Humans; Northern Ireland; P | 1981 |
Debendox in early pregnancy and fetal malformation.
Topics: Abnormalities, Drug-Induced; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combinations | 1981 |
Prospective study of suspected associations between certain drugs administered during early pregnancy and congenital malformations.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Estradiol; Fem | 1983 |
Congenital malformations.
Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Dicyclomine; Doxylamine; Drug Combinations; F | 1983 |
The Bendectin Saga: another American tragedy (Brent, '80).
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Jurispruden | 1983 |
Debendox in the dock.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug | 1980 |
Bendectin use during pregnancy.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Pregnancy; | 1982 |
Bendectin and fetal development. A study of Boston City Hospital.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug | 1982 |
The performance of three approximate confidence limit methods for the odds ratio.
Topics: Abnormalities, Drug-Induced; Breast Neoplasms; Dicyclomine; Doxylamine; Drug Combinations; Epidemiol | 1982 |
Debendox does not cause the Poland anomaly.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Antiemetics; Dicyclomine; Doxylamine; Drug Com | 1982 |
Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Female; Fluphenazine; | 1982 |
Bendectin (Debendox) as a risk factor for pyloric stenosis.
Topics: Abnormalities, Drug-Induced; Adult; Dicyclomine; Doxylamine; Drug Combinations; Female; Heart Defect | 1982 |
Vitamin B6 reduces cortisone-induced cleft palate in the mouse.
Topics: Abnormalities, Drug-Induced; Animals; Cells, Cultured; Cleft Palate; Cortisone; Female; Kinetics; Ma | 1982 |
The law and Bendectin.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Jurispruden | 1981 |
Is Bendectin a teratogen?
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Drug Evaluatio | 1981 |
Congenital anomalies in relation to the use of doxylamine/dicyclomine and other antenatal factors: an ongoing prospective study.
Topics: Abnormalities, Drug-Induced; Adult; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combi | 1981 |
Debendox and limb reduction deformities.
Topics: Abnormalities, Drug-Induced; Australia; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug C | 1981 |
A dearth of new drugs.
Topics: Abnormalities, Drug-Induced; Antiemetics; Doxylamine; Drug Combinations; Drug Evaluation; Drug Evalu | 1980 |
Debendox in pregnancy.
Topics: Abnormalities, Drug-Induced; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combinations | 1980 |
How safe is Bendectin?
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Drug Evaluation; Female; Hu | 1980 |
Debendox and congenital malformations in Northern Ireland.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug | 1980 |
The Bendectin debate.
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Femal | 1980 |
Bendectin and fetal malformations.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 1981 |
Bendectin case dismissed.
Topics: Abnormalities, Drug-Induced; Antiemetics; Child; Dicyclomine; Doxylamine; Drug Combinations; Drug In | 1995 |
Evaluating the admissibility of expert testimony.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Expert Testimo | 1994 |
Science, law, and the search for truth in the courtroom: lessons from Daubert v. Merrell Dow.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Expert Testimo | 1994 |
Admissibility of scientific testimony into evidence.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Drug Industry; | 1994 |
Study of prescription drugs in the first trimester and congenital malformations.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Pregnancy; | 1993 |
Supreme Court to judges: start thinking like scientists.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Drug Industry; Expert Testi | 1993 |
Court ruling on 'junk science' gives judges more say about what expert witness testimony to allow.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Drug Industry; | 1993 |
Supreme Court to weigh science.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Expert Testimo | 1993 |
From science to evidence: the testimony on causation in the Bendectin cases.
Topics: Abnormalities, Drug-Induced; Data Collection; Decision Making; Doxylamine; Drug Combinations; Expert | 1993 |
Daubert v. Merrell Dow: missed opportunity.
Topics: Abnormalities, Drug-Induced; Antiemetics; Doxylamine; Drug Combinations; Drug Industry; Expert Testi | 1995 |
Letter: Incidence of congenital limb-reduction deformities.
Topics: Abnormalities, Drug-Induced; Arm; Benzyl Compounds; Birth Weight; Congenital Abnormalities; England; | 1975 |
CDC study: no evidence for teratogenicity of Bendectin.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Heart | 1979 |
Teratogenicity testing in humans: a method demonstrating safety of bendectin.
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylam | 1978 |
Fetal malformation after Debendox treatment in early pregnancy.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug | 1978 |
Congenital deformities associated with Benedectin.
Topics: Abnormalities, Drug-Induced; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combinations | 1977 |
Congenital deformities associated with Bendectin.
Topics: Abnormalities, Drug-Induced; Adult; Cleft Lip; Cleft Palate; Cyclohexanecarboxylic Acids; Dicyclomin | 1977 |
Teratogenicity study in rats given high doses of pyridoxine (vitamin B6) during organogenesis.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Dose-Response Relationship, Drug; Female | 1975 |
Prescription drugs in the first trimester and congenital malformations.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Ectromelia; Fe | 1992 |
Risk, statistical inference, and the law of evidence: the use of epidemiological data in toxic tort cases.
Topics: Abnormalities, Drug-Induced; Antiemetics; Confidence Intervals; Data Interpretation, Statistical; Di | 1992 |
Effect of supplementation with folinic acid, vitamin B6, and vitamin B12 on valproic acid-induced teratogenesis in mice.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Drug Interactions; Embryo, Mammalian; | 1992 |
Further studies on protective effects of vitamins in cyclophosphamide-induced cleft palate.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cleft Palate; Cyclophosphamide; Female; Fetus; Li | 1990 |
Bendectin--birth defects controversy.
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Extre | 1990 |
[Neuro- and embryotoxic side effects of vitamin B6].
Topics: Abnormalities, Drug-Induced; Animals; Dose-Response Relationship, Drug; Female; Humans; Infant, Newb | 1989 |
Bendectin and human congenital malformations.
Topics: Abnormalities, Drug-Induced; Central Nervous System; Dicyclomine; Digestive System Abnormalities; Do | 1989 |
Agenesis of the corpus callosum and neural crest tumors.
Topics: Abdominal Neoplasms; Abnormalities, Drug-Induced; Agenesis of Corpus Callosum; Child; Child, Prescho | 1986 |
Developmental toxicity evaluation of Bendectin in CD rats.
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylam | 1988 |
The value of case reports in human teratology.
Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Eryth | 1986 |
Debendox.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Drug Com | 1986 |
Limb-reduction deformities and Debendox.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Infant, New | 1987 |
The weight of the evidence--or--more likely than not.
Topics: Abnormalities, Drug-Induced; Dicyclomine; District of Columbia; Doxylamine; Drug Combinations; Femal | 1986 |
Drugs and stillbirth.
Topics: Abnormalities, Drug-Induced; Adult; Anti-Bacterial Agents; Contraceptives, Oral; Dicyclomine; Doxyla | 1986 |
Comments on "Teratogen update:bendectin".
Topics: Abnormalities, Drug-Induced; Bibliographies as Topic; Dicyclomine; Doxylamine; Drug Combinations; Hu | 1985 |
The debendox saga.
Topics: Abnormalities, Drug-Induced; Antiemetics; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans | 1985 |
Debendox.
Topics: Abnormalities, Drug-Induced; Cyclohexanecarboxylic Acids; Dicyclomine; Doxylamine; Drug Combinations | 1986 |
Jury clears Bendectin.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Jurispruden | 1985 |
First-trimester drug use and congenital disorders.
Topics: Abnormalities, Drug-Induced; Brompheniramine; Congenital Abnormalities; Dicyclomine; Doxylamine; Dru | 1985 |
Editorial comment on comments on "Teratogen update: Bendectin".
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Humans; Methods; Pyridines; | 1985 |
Blame, compensation and birth defects.
Topics: Abnormalities, Drug-Induced; Australia; Congenital Abnormalities; Dicyclomine; Doxylamine; Drug Comb | 1985 |
Debendox revisited.
Topics: Abnormalities, Drug-Induced; Antiemetics; Cleft Lip; Cleft Palate; Dicyclomine; Doxylamine; Drug Com | 1985 |
Teratology and reproduction studies with an antinauseant.
Topics: Abnormalities, Drug-Induced; Animal Feed; Animals; Birth Weight; Female; Histamine H1 Antagonists; M | 1968 |
Cleft palate formation: a role for pyridoxine in the closure of the secondary palate in mice.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Cortisone; Diet; Female; Mice; Palate; Pregnancy | 1972 |
The effects of isonicotinic acid hydrazide on the early chick embryo.
Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Epithelium; Isoniazid; Nerve Degeneration; Neuro | 1973 |
[Hyperemesis in the first trimester of pregnancy: causes and therapeutic advances].
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Adult; Chlorpromazine; Female; Humans; Hyperem | 1967 |
[Effect of vitamin B 6 and antivitamin B 6 on the development of the chick embryo].
Topics: Abnormalities, Drug-Induced; Animals; Antimetabolites; Chick Embryo; In Vitro Techniques; Pyridoxine | 1965 |