pyridoxal phosphate has been researched along with Seizures in 97 studies
Pyridoxal Phosphate: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
pyridoxal 5'-phosphate : The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pyridoxine-dependent seizures have been recognised for 40 years, but the clinical and biochemical features are still not understood." | 8.82 | Pyridoxine-dependent seizures: a clinical and biochemical conundrum. ( Baxter, P, 2003) |
| "To investigate the short-term efficacy and safety of high-dose pyridoxine and pyridoxal 5-phosphate (P5P) in the treatment of inherited glycosylphosphatidylinositol (GPI) deficiency-associated epilepsy." | 8.12 | Pyridoxine or pyridoxal-5-phosphate treatment for seizures in glycosylphosphatidylinositol deficiency: A cohort study. ( Aledo-Serrano, A; Bayat, A; Boßelmann, C; de Sain-van der Velden, MGM; Gardella, E; Gil-Nagel, A; Korff, CM; Lund, AM; Møller, RS; Thomas, A; Weber, Y, 2022) |
| "We report on seizures, paroxysmal events, and electroencephalogram (EEG) findings in four female infants with pyridoxine-dependent epilepsy (PDE) and in one female with pyridoxine phosphate oxidase deficiency (PNPO)." | 7.76 | Seizures and paroxysmal events: symptoms pointing to the diagnosis of pyridoxine-dependent epilepsy and pyridoxine phosphate oxidase deficiency. ( Baumgartner, M; Clayton, PT; Jakobs, C; Keller, E; Mills, PB; Schmitt, B; Wohlrab, G, 2010) |
| "Pyridoxine-responsive seizures (PRS) and the role of pyridoxine (PN, vitamin B(6)) in hypophosphatasia (HPP) are incompletely understood." | 7.74 | Pyridoxine-responsive seizures as the first symptom of infantile hypophosphatasia caused by two novel missense mutations (c.677T>C, p.M226T; c.1112C>T, p.T371I) of the tissue-nonspecific alkaline phosphatase gene. ( Baumgartner-Sigl, S; Ericson, KL; Haberlandt, E; Högler, W; Mumm, S; Ryan, L; Scholl-Bürgi, S; Sergi, C; Whyte, MP, 2007) |
| "We show here that children with pyridoxine-dependent seizures (PDS) have mutations in the ALDH7A1 gene, which encodes antiquitin; these mutations abolish the activity of antiquitin as a delta1-piperideine-6-carboxylate (P6C)-alpha-aminoadipic semialdehyde (alpha-AASA) dehydrogenase." | 7.73 | Mutations in antiquitin in individuals with pyridoxine-dependent seizures. ( Baumgartner, M; Baxter, P; Clayton, PT; Jakobs, C; Mills, PB; Omran, H; Plecko, B; Struys, E; Tacke, U; Uhlenberg, B; Weschke, B; Willemsen, MA, 2006) |
| "To study the difference between pyridoxine (PN) and its active form, pyridoxal phosphate, (PLP) in control of idiopathic intractable epilepsy in children." | 7.73 | Pyridoxal phosphate is better than pyridoxine for controlling idiopathic intractable epilepsy. ( Chang, MY; Chou, ML; Hsieh, MY; Hung, PC; Kuo, MF; Lin, KL; Wang, HS, 2005) |
| "We previously identified vitamin B6 deficiency in a child presenting with seizures whose primary diagnosis was the inherited disorder hyperprolinemia type II." | 7.71 | Pyridoxal phosphate de-activation by pyrroline-5-carboxylic acid. Increased risk of vitamin B6 deficiency and seizures in hyperprolinemia type II. ( Farrant, RD; Langley, GJ; Mellor, JM; Mills, GA; Walker, V, 2001) |
| "Isoniazid-induced seizures respond poorly to anticonvulsants but well to pyridoxine (Vitamin B6); theophylline produces difficult-to-treat seizures with substantial morbidity and mortality." | 7.70 | Seizures induced by theophylline and isoniazid in mice. ( Bonner, AB; Peterson, SL; Weir, MR, 1999) |
| "An asphyxiated neonate with pyridoxine-dependent seizures and associated transient nonketotic hyperglycinemia is reported." | 7.70 | Transient nonketotic hyperglycinemia in an asphyxiated patient with pyridoxine-dependent seizures. ( Goto, K; Inutsuka, M; Izumi, T; Maeda, T, 2000) |
| "Theophylline-induced seizures have significant morbidity and mortality and are difficult to treat." | 7.69 | Pyridoxine as therapy in theophylline-induced seizures. ( Glenn, GM; Kelly, P; Krober, MS; McCarty, J; Weir, M, 1995) |
| "The intraventricular injection of pyridoxal phosphate (PLP; 1 mumole/brain) to rats causes convulsive seizures beginning 3 min after injection and lasting for about 20 min." | 7.67 | The effect of pyridoxal phosphate-induced convulsive seizures on rat brain phospholipid metabolism. ( Arienti, G; Binaglia, L; Corazzi, L; Piccinin, GL; Porcellati, G; Roberti, R, 1984) |
| "Pyridoxal phosphate was extremely high in CSF and plasma." | 5.40 | Infantile hypophosphatasia without bone deformities presenting with severe pyridoxine-resistant seizures. ( Abeling, NGGM; Bosch, AM; Cobben, JM; de Roo, MGA; Duran, M; Koelman, JHTM; Majoie, CB; Poll-The, BT, 2014) |
| "Although pyridoxine-dependent seizures have been reported for decades, pyridoxamine phosphate oxidase deficiency has only been recently described." | 5.39 | Seizures with decreased levels of pyridoxal phosphate in cerebrospinal fluid. ( Fequiere, PR; Goyal, M; Hyland, K; McGrath, TM, 2013) |
| "Pyridoxine-dependent seizures have been recognised for 40 years, but the clinical and biochemical features are still not understood." | 4.82 | Pyridoxine-dependent seizures: a clinical and biochemical conundrum. ( Baxter, P, 2003) |
| " Both zinc and pyridoxal phosphate (PLP) deficiency and excess have been reported to produce epileptiform seizures, which are blocked by gamma-aminobutyric acid (GABA)." | 4.78 | Hippocampal zinc thionein and pyridoxal phosphate modulate synaptic functions. ( Ebadi, M; Murrin, LC; Pfeiffer, RF, 1990) |
| "To investigate the short-term efficacy and safety of high-dose pyridoxine and pyridoxal 5-phosphate (P5P) in the treatment of inherited glycosylphosphatidylinositol (GPI) deficiency-associated epilepsy." | 4.12 | Pyridoxine or pyridoxal-5-phosphate treatment for seizures in glycosylphosphatidylinositol deficiency: A cohort study. ( Aledo-Serrano, A; Bayat, A; Boßelmann, C; de Sain-van der Velden, MGM; Gardella, E; Gil-Nagel, A; Korff, CM; Lund, AM; Møller, RS; Thomas, A; Weber, Y, 2022) |
| " Though atonic seizures were observed during the treatment, it disappeared after isoniazid discontinuation and pyridoxal phosphate administration." | 3.91 | Clinical findings and treatment of disseminated 'Mycobacterium avium subspecies hominissuis' infection in a domestic cat. ( Hatoya, S; Hirai, K; Kanegi, R; Nabetani, T; Sugiura, K; Tanaka, T; Wada, Y; Yasugi, M, 2019) |
| " It frequently accompanies pyridoxine-responsive seizures." | 3.91 | Findings of amplitude-integrated electroencephalogram recordings and serum vitamin B6 metabolites in perinatal lethal hypophosphatasia during enzyme replacement therapy. ( Akiyama, T; Hayakawa, M; Ishiguro, T; Kotani, T; Michigami, T; Muramatsu, Y; Sugiyama, Y; Tachikawa, K; Tsuda, H; Ueda, K, 2019) |
| "High-dose pyridoxal phosphate is a useful treatment for HPP-induced seizures and might improve reticular formation lesions." | 3.88 | Infantile hypophosphatasia combined with vitamin B6-responsive seizures and reticular formation lesions on magnetic resonance imaging: A case report. ( Baba, H; Doi, T; Fukazawa, M; Masumoto, N; Mihara, F; Mizuno, Y; Nakayama, H; Sasazuki, M; Tezuka, J; Tsutsumi, Y, 2018) |
| "To determine whether patients with pyridoxine-responsive seizures but normal biomarkers for antiquitin deficiency and normal sequencing of the ALDH7A1 gene may have PNPO mutations." | 3.80 | Pyridoxine responsiveness in novel mutations of the PNPO gene. ( Abela, L; Clayton, P; Connolly, M; Hasselmann, O; Hofer, D; Kanz, S; Maier, O; Mills, P; Paschke, E; Paul, K; Plecko, B; Schmiedel, G; Stockler, S; Struys, E; Wolf, N, 2014) |
| "In children, vitamin B(6) (pyridoxine) deficiency has been described as a cause of seizures that are refractory to conventional antiepileptic medications." | 3.77 | Vitamin B6 deficiency: a potential cause of refractory seizures in adults. ( Cook, CH; Gerlach, AT; Stawicki, SP; Steinberg, SM; Thomas, S; Whitmill, ML, 2011) |
| "We report on seizures, paroxysmal events, and electroencephalogram (EEG) findings in four female infants with pyridoxine-dependent epilepsy (PDE) and in one female with pyridoxine phosphate oxidase deficiency (PNPO)." | 3.76 | Seizures and paroxysmal events: symptoms pointing to the diagnosis of pyridoxine-dependent epilepsy and pyridoxine phosphate oxidase deficiency. ( Baumgartner, M; Clayton, PT; Jakobs, C; Keller, E; Mills, PB; Schmitt, B; Wohlrab, G, 2010) |
| "Pyridoxine-responsive seizures (PRS) and the role of pyridoxine (PN, vitamin B(6)) in hypophosphatasia (HPP) are incompletely understood." | 3.74 | Pyridoxine-responsive seizures as the first symptom of infantile hypophosphatasia caused by two novel missense mutations (c.677T>C, p.M226T; c.1112C>T, p.T371I) of the tissue-nonspecific alkaline phosphatase gene. ( Baumgartner-Sigl, S; Ericson, KL; Haberlandt, E; Högler, W; Mumm, S; Ryan, L; Scholl-Bürgi, S; Sergi, C; Whyte, MP, 2007) |
| "We show here that children with pyridoxine-dependent seizures (PDS) have mutations in the ALDH7A1 gene, which encodes antiquitin; these mutations abolish the activity of antiquitin as a delta1-piperideine-6-carboxylate (P6C)-alpha-aminoadipic semialdehyde (alpha-AASA) dehydrogenase." | 3.73 | Mutations in antiquitin in individuals with pyridoxine-dependent seizures. ( Baumgartner, M; Baxter, P; Clayton, PT; Jakobs, C; Mills, PB; Omran, H; Plecko, B; Struys, E; Tacke, U; Uhlenberg, B; Weschke, B; Willemsen, MA, 2006) |
| "To study the difference between pyridoxine (PN) and its active form, pyridoxal phosphate, (PLP) in control of idiopathic intractable epilepsy in children." | 3.73 | Pyridoxal phosphate is better than pyridoxine for controlling idiopathic intractable epilepsy. ( Chang, MY; Chou, ML; Hsieh, MY; Hung, PC; Kuo, MF; Lin, KL; Wang, HS, 2005) |
| "We previously identified vitamin B6 deficiency in a child presenting with seizures whose primary diagnosis was the inherited disorder hyperprolinemia type II." | 3.71 | Pyridoxal phosphate de-activation by pyrroline-5-carboxylic acid. Increased risk of vitamin B6 deficiency and seizures in hyperprolinemia type II. ( Farrant, RD; Langley, GJ; Mellor, JM; Mills, GA; Walker, V, 2001) |
| "An asphyxiated neonate with pyridoxine-dependent seizures and associated transient nonketotic hyperglycinemia is reported." | 3.70 | Transient nonketotic hyperglycinemia in an asphyxiated patient with pyridoxine-dependent seizures. ( Goto, K; Inutsuka, M; Izumi, T; Maeda, T, 2000) |
| "Isoniazid-induced seizures respond poorly to anticonvulsants but well to pyridoxine (Vitamin B6); theophylline produces difficult-to-treat seizures with substantial morbidity and mortality." | 3.70 | Seizures induced by theophylline and isoniazid in mice. ( Bonner, AB; Peterson, SL; Weir, MR, 1999) |
| "Theophylline-induced seizures have significant morbidity and mortality and are difficult to treat." | 3.69 | Pyridoxine as therapy in theophylline-induced seizures. ( Glenn, GM; Kelly, P; Krober, MS; McCarty, J; Weir, M, 1995) |
| "The intraventricular injection of pyridoxal phosphate (PLP; 1 mumole/brain) to rats causes convulsive seizures beginning 3 min after injection and lasting for about 20 min." | 3.67 | The effect of pyridoxal phosphate-induced convulsive seizures on rat brain phospholipid metabolism. ( Arienti, G; Binaglia, L; Corazzi, L; Piccinin, GL; Porcellati, G; Roberti, R, 1984) |
| "The anticonvulsive action of diazepam, carbamazepine, sodium valproate and their combinations with pyridoxal-5-phosphate, nicotinamide, and alpha-tocopherol were investigated in acute experiments on mice with corazole-induced seizures." | 3.67 | [Effect of diazepam, carbamazepine, sodium valproate and their combinations with vitamin preparations on epileptic activity]. ( Kryzhanovskiĭ, GN; Shandra, AA, 1985) |
| "1 The release of endogenous gamma-aminobutyric acid (GABA) from slices of rat cortex, hippocampus and striatum prepared both 30 min and 24 h after the last of a series of electroconvulsive shocks (5 seizures given spread out over 10 days) has been investigated." | 3.67 | The effect of repeated electroconvulsive shock on GABA synthesis and release in regions of rat brain. ( Green, AR; Vincent, ND, 1987) |
| " Seizures were induced by pyridoxal phosphate-gamma-glutamyl hydrazone (PLPGH), a drug previously reported to reduce the levels of pyridoxal 5'-phosphate and as a consequence to inhibit the activity of glutamate decarboxylase in brain of adult mice." | 3.65 | Seizure susceptibility in the developing mouse and its relationship to glutamate decarboxylase and pyridoxal phosphate in brain. ( Pasantes-Morales, H; Pérez de la Mora, M; Taborda, E; Tapia, R, 1975) |
| "In spite of effective seizure control with PLP, approximately 56% of patients affected with PLP-dependent epilepsy suffer developmental delay/intellectual disability." | 2.72 | Phenotypic and molecular spectrum of pyridoxamine-5'-phosphate oxidase deficiency: A scoping review of 87 cases of pyridoxamine-5'-phosphate oxidase deficiency. ( Abdelhakim, M; Adly, N; Alghamdi, M; Alghanem, B; Arold, ST; Bashiri, FA; Jamjoom, DZ; Sumaily, KM, 2021) |
| "About 7/18 (39%) of patients showed seizure-free with pyridoxine (PN) or pyridoxal-5'-phosphate treatment." | 1.91 | Analysis for variable manifestations and molecular characteristics of pyridox(am)ine-5'-phosphate oxidase (PNPO) deficiency. ( Gong, P; Jiao, X; Niu, Y; Xu, Z; Yang, Z; Zhang, Y, 2023) |
| "The initial presentation of acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is indistinguishable from that of complex febrile seizures (FS), which poses a great diagnostic challenge for clinicians." | 1.56 | Vitamin B6 in acute encephalopathy with biphasic seizures and late reduced diffusion. ( Akiyama, T; Hanaoka, Y; Hyodo, Y; Ito, T; Kimura, N; Kobayashi, K; Miyahara, H; Mogami, Y; Toda, S; Tokorodani, C, 2020) |
| "Mabry syndrome is the triad of seizures, hyperphosphatasia, and mental disability." | 1.48 | Mabry Syndrome in a Child of South Asian Descent. ( Durrani, MYK; Humayun, KN; Ibrahim, SH; Sohail, AH, 2018) |
| "Pyridoxine-sensitive seizures characterize severe forms of infantile HPP." | 1.46 | Neuromuscular features of hypophosphatasia. ( Fonta, C; Salles, JP, 2017) |
| "Neonatal onset seizures in PLP responsive epilepsy are usually resistant to common anticonvulsants and pyridoxine, but respond to PLP." | 1.42 | Pyridoxal 5ꞌ-phosphate-responsive epilepsy with novel mutations in the PNPO gene: a case report. ( Damrongphol, P; Ittiwut, C; Ittiwut, R; Shotelersuk, V; Suphapeetiporn, K; Veeravigrom, M, 2015) |
| "Follow-up at 6 years of age showed a seizure-free young girl (on 42 mg/kg/day PLP) with normal development but mild elevation of liver function tests." | 1.42 | A preterm neonate with seizures unresponsive to conventional treatment. ( Clayton, PT; Del Giudice, E; Mills, P; Raimondi, F, 2015) |
| "Pyridoxal phosphate was extremely high in CSF and plasma." | 1.40 | Infantile hypophosphatasia without bone deformities presenting with severe pyridoxine-resistant seizures. ( Abeling, NGGM; Bosch, AM; Cobben, JM; de Roo, MGA; Duran, M; Koelman, JHTM; Majoie, CB; Poll-The, BT, 2014) |
| "Although pyridoxine-dependent seizures have been reported for decades, pyridoxamine phosphate oxidase deficiency has only been recently described." | 1.39 | Seizures with decreased levels of pyridoxal phosphate in cerebrospinal fluid. ( Fequiere, PR; Goyal, M; Hyland, K; McGrath, TM, 2013) |
| "This seizure-like swimming pattern was alleviated by the addition of either pyridoxal-5'-phosphate (PLP) or GABA and responded quickly to the anti-convulsing activity of gabapentin and phenytoin, two commonly prescribed anti-epileptic drugs (AEDs)." | 1.38 | Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5'-phosphate, GABA and anti-epileptic drugs. ( Chang, WN; Du, HC; Fu, TF; Hsiao, TH; Kao, TT; Lee, GH; Safo, MK; Sung, SY, 2012) |
| "Correlated with this increased seizure susceptibility were enhanced levels of synaptosomal aspartate and glutamate, and a diminished gamma-aminobutyric acid (GABA) level." | 1.27 | Alteration of amino acid metabolism in epileptogenic mice by elevation of brain pyridoxal phosphate. ( Chung, SH; Murphy, RA; Norris, DK, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 56 (57.73) | 18.7374 |
| 1990's | 4 (4.12) | 18.2507 |
| 2000's | 11 (11.34) | 29.6817 |
| 2010's | 19 (19.59) | 24.3611 |
| 2020's | 7 (7.22) | 2.80 |
| Authors | Studies |
|---|---|
| Barile, A | 2 |
| Mills, P | 3 |
| di Salvo, ML | 2 |
| Graziani, C | 1 |
| Bunik, V | 2 |
| Clayton, P | 2 |
| Contestabile, R | 2 |
| Tramonti, A | 2 |
| Bayat, A | 1 |
| Aledo-Serrano, A | 1 |
| Gil-Nagel, A | 1 |
| Korff, CM | 1 |
| Thomas, A | 1 |
| Boßelmann, C | 1 |
| Weber, Y | 1 |
| Gardella, E | 1 |
| Lund, AM | 1 |
| de Sain-van der Velden, MGM | 1 |
| Møller, RS | 1 |
| Jiao, X | 1 |
| Gong, P | 1 |
| Niu, Y | 1 |
| Xu, Z | 1 |
| Zhang, Y | 1 |
| Yang, Z | 1 |
| Kanegi, R | 1 |
| Yasugi, M | 1 |
| Nabetani, T | 1 |
| Tanaka, T | 1 |
| Wada, Y | 1 |
| Hirai, K | 1 |
| Sugiura, K | 1 |
| Hatoya, S | 1 |
| Akiyama, T | 2 |
| Toda, S | 1 |
| Kimura, N | 1 |
| Mogami, Y | 1 |
| Hanaoka, Y | 1 |
| Tokorodani, C | 1 |
| Ito, T | 1 |
| Miyahara, H | 1 |
| Hyodo, Y | 1 |
| Kobayashi, K | 1 |
| Nogués, I | 1 |
| Alghamdi, M | 1 |
| Bashiri, FA | 1 |
| Abdelhakim, M | 1 |
| Adly, N | 1 |
| Jamjoom, DZ | 1 |
| Sumaily, KM | 1 |
| Alghanem, B | 1 |
| Arold, ST | 1 |
| Ghatge, MS | 1 |
| Al Mughram, M | 1 |
| Omar, AM | 1 |
| Safo, MK | 2 |
| Klotz, KA | 1 |
| Lemke, JR | 1 |
| Korinthenberg, R | 1 |
| Jacobs, J | 1 |
| Fukazawa, M | 1 |
| Tezuka, J | 1 |
| Sasazuki, M | 1 |
| Masumoto, N | 1 |
| Baba, H | 1 |
| Doi, T | 1 |
| Tsutsumi, Y | 1 |
| Mizuno, Y | 1 |
| Mihara, F | 1 |
| Nakayama, H | 1 |
| Guerriero, RM | 1 |
| Patel, AA | 1 |
| Walsh, B | 1 |
| Baumer, FM | 1 |
| Shah, AS | 1 |
| Peters, JM | 1 |
| Rodan, LH | 1 |
| Agrawal, PB | 1 |
| Pearl, PL | 1 |
| Takeoka, M | 1 |
| Fonta, C | 1 |
| Salles, JP | 1 |
| Borst, AJ | 1 |
| Tchapyjnikov, D | 1 |
| Sohail, AH | 1 |
| Durrani, MYK | 1 |
| Ibrahim, SH | 1 |
| Humayun, KN | 1 |
| Ishiguro, T | 1 |
| Sugiyama, Y | 1 |
| Ueda, K | 1 |
| Muramatsu, Y | 1 |
| Tsuda, H | 1 |
| Kotani, T | 1 |
| Michigami, T | 1 |
| Tachikawa, K | 1 |
| Hayakawa, M | 1 |
| Goyal, M | 1 |
| Fequiere, PR | 1 |
| McGrath, TM | 1 |
| Hyland, K | 1 |
| de Roo, MGA | 1 |
| Abeling, NGGM | 1 |
| Majoie, CB | 1 |
| Bosch, AM | 1 |
| Koelman, JHTM | 1 |
| Cobben, JM | 1 |
| Duran, M | 1 |
| Poll-The, BT | 1 |
| Ware, TL | 1 |
| Earl, J | 2 |
| Salomons, GS | 1 |
| Struys, EA | 1 |
| Peters, HL | 1 |
| Howell, KB | 1 |
| Pitt, JJ | 1 |
| Freeman, JL | 1 |
| Plecko, B | 3 |
| Paul, K | 1 |
| Paschke, E | 1 |
| Maier, O | 1 |
| Hasselmann, O | 1 |
| Schmiedel, G | 1 |
| Kanz, S | 1 |
| Connolly, M | 1 |
| Wolf, N | 1 |
| Struys, E | 2 |
| Stockler, S | 2 |
| Abela, L | 1 |
| Hofer, D | 1 |
| Dietmann, A | 1 |
| Wallner, B | 1 |
| König, R | 1 |
| Friedrich, K | 1 |
| Pfausler, B | 1 |
| Deisenhammer, F | 1 |
| Griesmacher, A | 1 |
| Seger, C | 1 |
| Matuja, W | 1 |
| JilekAall, L | 1 |
| Winkler, AS | 1 |
| Schmutzhard, E | 1 |
| Raimondi, F | 1 |
| Clayton, PT | 3 |
| Del Giudice, E | 1 |
| Veeravigrom, M | 1 |
| Damrongphol, P | 1 |
| Ittiwut, R | 1 |
| Ittiwut, C | 1 |
| Suphapeetiporn, K | 1 |
| Shotelersuk, V | 1 |
| Balasubramaniam, S | 1 |
| Bowling, F | 1 |
| Carpenter, K | 1 |
| Chaitow, J | 1 |
| Pitt, J | 1 |
| Mornet, E | 1 |
| Sillence, D | 1 |
| Ellaway, C | 1 |
| Schmitt, B | 1 |
| Baumgartner, M | 2 |
| Mills, PB | 2 |
| Jakobs, C | 2 |
| Keller, E | 1 |
| Wohlrab, G | 1 |
| Gerlach, AT | 1 |
| Thomas, S | 1 |
| Stawicki, SP | 1 |
| Whitmill, ML | 1 |
| Steinberg, SM | 1 |
| Cook, CH | 1 |
| Lee, GH | 1 |
| Sung, SY | 1 |
| Chang, WN | 1 |
| Kao, TT | 1 |
| Du, HC | 1 |
| Hsiao, TH | 1 |
| Fu, TF | 1 |
| Baxter, P | 3 |
| QUADBECK, G | 1 |
| SARTORI, GD | 1 |
| MASSIEU, GH | 5 |
| TAPIA, R | 14 |
| PASANTES, H | 3 |
| ORTEGA, BG | 2 |
| UCHIDA, T | 1 |
| O'BRIEN, RD | 2 |
| KIRKPATRICK, M | 1 |
| MILLER, PS | 1 |
| BONAVITA, V | 2 |
| GUARNERI, R | 1 |
| MONACO, P | 1 |
| Wang, HS | 1 |
| Kuo, MF | 1 |
| Chou, ML | 1 |
| Hung, PC | 1 |
| Lin, KL | 1 |
| Hsieh, MY | 1 |
| Chang, MY | 1 |
| Willemsen, MA | 1 |
| Omran, H | 1 |
| Tacke, U | 1 |
| Uhlenberg, B | 1 |
| Weschke, B | 1 |
| Baumgartner-Sigl, S | 1 |
| Haberlandt, E | 1 |
| Mumm, S | 1 |
| Scholl-Bürgi, S | 1 |
| Sergi, C | 1 |
| Ryan, L | 1 |
| Ericson, KL | 1 |
| Whyte, MP | 1 |
| Högler, W | 1 |
| Kang, TC | 1 |
| Kang, JH | 1 |
| Kim, HT | 1 |
| Lee, SJ | 1 |
| Choi, UK | 1 |
| Kim, JE | 1 |
| Kwak, SE | 1 |
| Kim, DW | 1 |
| Choi, SY | 1 |
| Kwon, OS | 1 |
| Minard, FN | 1 |
| Bonasera, N | 1 |
| Smorto, M | 1 |
| Pérez de la Mora, M | 6 |
| Awapara, J | 2 |
| Shin, YS | 1 |
| Rasshofer, R | 1 |
| Endres, W | 1 |
| Kryzhanovskiĭ, GN | 4 |
| Shandra, AA | 4 |
| Nikushkin, EV | 1 |
| Godlevskiĭ, LS | 1 |
| Griffiths, R | 2 |
| Williams, DC | 1 |
| O'Neill, C | 1 |
| Dewhurst, IC | 1 |
| Ekuwem, CE | 1 |
| Sinclair, CD | 1 |
| Arienti, G | 1 |
| Corazzi, L | 1 |
| Piccinin, GL | 1 |
| Roberti, R | 1 |
| Binaglia, L | 1 |
| Porcellati, G | 1 |
| Joshioka, T | 1 |
| Iitaka, K | 1 |
| Kasai, N | 1 |
| Sakai, T | 1 |
| Wilson, RG | 1 |
| Davis, RE | 1 |
| Itoh, M | 1 |
| Ebadi, M | 3 |
| Glenn, GM | 1 |
| Krober, MS | 1 |
| Kelly, P | 1 |
| McCarty, J | 1 |
| Weir, M | 1 |
| Tunnicliff, G | 1 |
| Ngo, TT | 1 |
| Bonner, AB | 1 |
| Peterson, SL | 1 |
| Weir, MR | 1 |
| Maeda, T | 1 |
| Inutsuka, M | 1 |
| Goto, K | 1 |
| Izumi, T | 1 |
| Farrant, RD | 1 |
| Walker, V | 1 |
| Mills, GA | 1 |
| Mellor, JM | 1 |
| Langley, GJ | 1 |
| Salazar, P | 1 |
| Fujisawa, M | 1 |
| Hori, Y | 1 |
| Nakajima, M | 1 |
| Shimada, K | 1 |
| Yoshikawa, H | 1 |
| Wada, K | 1 |
| Pasantes-Morales, H | 1 |
| Taborda, E | 1 |
| Klangkalya, B | 1 |
| Riva, E | 1 |
| Borzani, M | 1 |
| Motta, G | 1 |
| Giovannini, M | 1 |
| Stone, WE | 1 |
| Javid, MJ | 1 |
| Sandoval, ME | 1 |
| Contreras, P | 1 |
| Murakami, Y | 2 |
| Matsuda, M | 1 |
| Murrin, LC | 1 |
| Pfeiffer, RF | 1 |
| Ryzhov, IV | 1 |
| Lapin, IP | 1 |
| Egbuta, JO | 1 |
| Green, AR | 1 |
| Vincent, ND | 1 |
| Norris, DK | 1 |
| Murphy, RA | 1 |
| Chung, SH | 1 |
| De la Mora, MP | 1 |
| Reinken, L | 1 |
| Bilodeau, F | 1 |
| Furst, A | 1 |
| Gustavson, WR | 1 |
| Gallagher, BB | 2 |
| Sprince, H | 1 |
| Parker, CM | 1 |
| Smith, GG | 1 |
| Murakami, K | 1 |
| Makino, K | 1 |
| Yamashita, J | 1 |
| Shellenberger, MK | 1 |
| Culver, BW | 1 |
| Alderman, JL | 1 |
| Feria-Velasco, A | 1 |
| Frimpter, GW | 1 |
| Andelman, RJ | 1 |
| George, WF | 1 |
| Ressler, C | 1 |
| Koga, T | 1 |
| Cornish, HH | 2 |
| Dakshinamurti, K | 1 |
| Stephens, MC | 1 |
| Wiechert, P | 3 |
| Göllnitz, G | 3 |
| Lamar, C | 1 |
| Kosower, NS | 1 |
| Rock, RA | 1 |
| Geake, CL | 1 |
| Barth, ML | 1 |
10 reviews available for pyridoxal phosphate and Seizures
| Article | Year |
|---|---|
Phenotypic and molecular spectrum of pyridoxamine-5'-phosphate oxidase deficiency: A scoping review of 87 cases of pyridoxamine-5'-phosphate oxidase deficiency.
Topics: Brain Diseases, Metabolic; Epilepsy; Humans; Hypoxia-Ischemia, Brain; Metabolic Diseases; Mutation; | 2021 |
Inborn errors in the vitamin B6 salvage enzymes associated with neonatal epileptic encephalopathy and other pathologies.
Topics: Animals; Brain Diseases, Metabolic; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Metabolism, In | 2021 |
Vitamin B6 dependent seizures.
Topics: Animals; Electroencephalography; Humans; Pyridoxal Phosphate; Pyridoxaminephosphate Oxidase; Seizure | 2009 |
Pyridoxine-dependent seizures: a clinical and biochemical conundrum.
Topics: Drug Overdose; gamma-Aminobutyric Acid; Humans; Pyridoxal Phosphate; Pyridoxine; Seizures | 2003 |
Functional modification of proteins of the nervous system by pyridoxal 5'-phosphate.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Nerve Tissue Proteins; Nervous System; Neuro | 1998 |
Hippocampal zinc thionein and pyridoxal phosphate modulate synaptic functions.
Topics: Animals; Brain; Enzyme Activation; gamma-Aminobutyric Acid; Hippocampus; Metallothionein; Pyridoxal | 1990 |
[Endogenous convulsants (review)].
Topics: Amino Acids; Animals; Carbolines; Cats; Cerebral Cortex; Convulsants; Cysteic Acid; Cysteine; Diseas | 1986 |
[Scope and effect of vitamin B6 in newborn infants and children].
Topics: Amino Acids; Anemia, Hypochromic; Aspartate Aminotransferases; Brain; Coenzymes; Drug Antagonism; Fe | 1974 |
Vitamin B6-dependency syndromes. New horizons in nutrition.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Aminobutyrates; Anemia, Sideroblastic; Animals; Child; | 1969 |
The role of GABA and related amino acids in some functions of the central nervous system. A review.
Topics: Amino Acids; Aminobutyrates; Animals; Carboxy-Lyases; Central Nervous System; Humans; Mental Disorde | 1969 |
87 other studies available for pyridoxal phosphate and Seizures
| Article | Year |
|---|---|
Characterization of Novel Pathogenic Variants Causing Pyridox(am)ine 5'-Phosphate Oxidase-Dependent Epilepsy.
Topics: Brain Diseases, Metabolic; Epilepsy; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Metabolic Dis | 2021 |
Pyridoxine or pyridoxal-5-phosphate treatment for seizures in glycosylphosphatidylinositol deficiency: A cohort study.
Topics: Cohort Studies; Drug Resistant Epilepsy; Epilepsy; Female; Glycosylphosphatidylinositols; Humans; In | 2022 |
Analysis for variable manifestations and molecular characteristics of pyridox(am)ine-5'-phosphate oxidase (PNPO) deficiency.
Topics: Brain Diseases, Metabolic; Humans; Hypoxia-Ischemia, Brain; Metabolic Diseases; Oxidoreductases; Pho | 2023 |
Clinical findings and treatment of disseminated 'Mycobacterium avium subspecies hominissuis' infection in a domestic cat.
Topics: Animals; Anti-Bacterial Agents; Cat Diseases; Cats; Drug Therapy, Combination; Isoniazid; Liver; Lun | 2019 |
Vitamin B6 in acute encephalopathy with biphasic seizures and late reduced diffusion.
Topics: Brain Diseases; Child, Preschool; Female; Humans; Infant; Male; Pyridoxal; Pyridoxal Phosphate; Seiz | 2020 |
Molecular characterization of pyridoxine 5'-phosphate oxidase and its pathogenic forms associated with neonatal epileptic encephalopathy.
Topics: Allosteric Regulation; Allosteric Site; Brain Diseases, Metabolic; Catalytic Domain; Crystallography | 2020 |
Vitamin B6-Responsive Epilepsy due to a Novel KCNQ2 Mutation.
Topics: Anticonvulsants; Brain; Epilepsy; Female; Humans; Infant; KCNQ2 Potassium Channel; Mutation; Pyridox | 2017 |
Infantile hypophosphatasia combined with vitamin B6-responsive seizures and reticular formation lesions on magnetic resonance imaging: A case report.
Topics: Anticonvulsants; Diagnosis, Differential; Female; Humans; Hypophosphatasia; Infant, Newborn; Pyridox | 2018 |
Systemic Manifestations in Pyridox(am)ine 5'-Phosphate Oxidase Deficiency.
Topics: Brain Diseases, Metabolic; Electroencephalography; Epilepsy; Female; Humans; Hypoxia-Ischemia, Brain | 2017 |
Neuromuscular features of hypophosphatasia.
Topics: Adult; Alkaline Phosphatase; Animals; Biomarkers; Brain Diseases; Chronic Pain; Disease Models, Anim | 2017 |
B
Topics: Child; Disease Progression; Hemophilia A; Hemorrhage; Humans; Male; Pyridoxal Phosphate; Seizures; V | 2018 |
Mabry Syndrome in a Child of South Asian Descent.
Topics: Abnormalities, Multiple; Brain; Humans; Infant; Intellectual Disability; Male; Phosphorus Metabolism | 2018 |
Findings of amplitude-integrated electroencephalogram recordings and serum vitamin B6 metabolites in perinatal lethal hypophosphatasia during enzyme replacement therapy.
Topics: Alkaline Phosphatase; Electroencephalography; Enzyme Replacement Therapy; Female; Humans; Hypophosph | 2019 |
Seizures with decreased levels of pyridoxal phosphate in cerebrospinal fluid.
Topics: Adolescent; Biomarkers; Child, Preschool; Female; Humans; Infant; Male; Pyridoxal Phosphate; Seizure | 2013 |
Infantile hypophosphatasia without bone deformities presenting with severe pyridoxine-resistant seizures.
Topics: Alkaline Phosphatase; Drug Resistance; Epilepsy; Humans; Hypophosphatasia; Infant; Male; Pyridoxal P | 2014 |
Typical and atypical phenotypes of PNPO deficiency with elevated CSF and plasma pyridoxamine on treatment.
Topics: Brain Diseases, Metabolic; Child; Child, Preschool; Electroencephalography; Humans; Hypoxia-Ischemia | 2014 |
Pyridoxine responsiveness in novel mutations of the PNPO gene.
Topics: Aldehyde Dehydrogenase; Alleles; Animals; Brain Diseases, Metabolic; CHO Cells; Chromosome Deletion; | 2014 |
Nodding syndrome in Tanzania may not be associated with circulating anti-NMDA-and anti-VGKC receptor antibodies or decreased pyridoxal phosphate serum levels-a pilot study.
Topics: Adolescent; Adult; Aged; Autoantibodies; Case-Control Studies; Epilepsy; Female; Humans; Male; Middl | 2014 |
A preterm neonate with seizures unresponsive to conventional treatment.
Topics: Anticonvulsants; Diagnosis, Differential; Female; Humans; Infant, Newborn; Infant, Premature; Liver; | 2015 |
Pyridoxal 5ꞌ-phosphate-responsive epilepsy with novel mutations in the PNPO gene: a case report.
Topics: Brain Diseases, Metabolic; Female; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Mutation; Pyrid | 2015 |
Perinatal hypophosphatasia presenting as neonatal epileptic encephalopathy with abnormal neurotransmitter metabolism secondary to reduced co-factor pyridoxal-5'-phosphate availability.
Topics: Alkaline Phosphatase; Anticonvulsants; Biogenic Monoamines; Brain Diseases, Metabolic; Fatal Outcome | 2010 |
Seizures and paroxysmal events: symptoms pointing to the diagnosis of pyridoxine-dependent epilepsy and pyridoxine phosphate oxidase deficiency.
Topics: Aldehyde Dehydrogenase; Anticonvulsants; Brain; Brain Diseases, Metabolic; Diagnosis, Differential; | 2010 |
Vitamin B6 deficiency: a potential cause of refractory seizures in adults.
Topics: Aged; Drug Resistance; Humans; Male; Middle Aged; Pyridoxal Phosphate; Pyridoxine; Seizures; Vitamin | 2011 |
Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5'-phosphate, GABA and anti-epileptic drugs.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbon; Folic Acid; gamma-Aminobutyric Acid; Larva; Mode | 2012 |
[Influence of pyridoxine and pyridoxal-5-phosphate on thiosemicarbazide cramps in rats].
Topics: Animals; Coenzymes; Muscle Cramp; Phosphates; Pyridoxal Phosphate; Pyridoxine; Rats; Seizures; Semic | 1957 |
CONVULSANT EFFECT OF L-GLUTAMIC ACID-GAMMA-HYDRAZIDE BY SIMULTANEOUS TREATMENT WITH PYRIDOXAL PHOSPHATE.
Topics: Alanine; Aminobutyrates; Animals; Aspartic Acid; Brain; Carboxy-Lyases; Convulsants; Glutamates; Glu | 1964 |
THE EFFECTS OF HYDRAZINES ON RAT BRAIN 5-HYDROXYTRYPTAMINE, NOREPINEPHRINE, AND GAMMA-AMINOBUTYRIC ACID.
Topics: Aminobutyrates; Cerebellum; Cerebral Cortex; Chromatography; Diencephalon; Fluorescence; gamma-Amino | 1964 |
POISONING OF THE RAT BY HYDRAZINE AND ALKYLHYDRAZINES.
Topics: Antidotes; Blood Glucose; Hydrazines; Pharmacology; Pyridoxal Phosphate; Pyridoxine; Rats; Research; | 1964 |
NEUROPHYSIOLOGICAL AND NEUROCHEMICAL STUDIES WITH THE ISONICOTINOYLHYDRAZONE OF PYRIDOXAL 5-PHOSPHATE.
Topics: Aminobutyrates; Brain; Brain Chemistry; Carboxy-Lyases; Cats; Cerebellum; Electrophysiology; Frontal | 1964 |
Pyridoxine or pyridoxal phosphate for intractable seizures?
Topics: Anticonvulsants; Child; Drug Resistance; Humans; Pyridoxal Phosphate; Pyridoxine; Seizures; Treatmen | 2005 |
Pyridoxal phosphate is better than pyridoxine for controlling idiopathic intractable epilepsy.
Topics: Administration, Oral; Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Administration Sche | 2005 |
Mutations in antiquitin in individuals with pyridoxine-dependent seizures.
Topics: Aldehyde Dehydrogenase; Animals; Bacterial Proteins; Child; Child, Preschool; CHO Cells; Cricetinae; | 2006 |
Pyridoxine-responsive seizures as the first symptom of infantile hypophosphatasia caused by two novel missense mutations (c.677T>C, p.M226T; c.1112C>T, p.T371I) of the tissue-nonspecific alkaline phosphatase gene.
Topics: Alkaline Phosphatase; Ethanolamines; Exons; Fatal Outcome; Female; Humans; Hypercalcemia; Hypercalci | 2007 |
Anticonvulsant characteristics of pyridoxyl-gamma-aminobutyrate, PL-GABA.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Drug Tolerance; Electrophysiology; | 2008 |
Relationships among pyridoxal phosphate, vitamin B6-deficiency, and convulsions induced by 1,1-dimethylhydrazine.
Topics: Animals; Brain Chemistry; Centrifugation; Chromatography, Ion Exchange; Fluorometry; Hydrazines; Mal | 1967 |
Isoniazid seizures in the developing rat and the content of pyridoxal 5-phosphate in the brain.
Topics: Animals; Animals, Newborn; Brain; Brain Chemistry; Fluorometry; Isoniazid; Pyridoxal Phosphate; Rats | 1967 |
Free amino acids and glutamate decarboxylase activity in brain of mice during drug-induced convulsions.
Topics: Alanine; Aminobutyrates; Animals; Aspartic Acid; Brain Chemistry; Carboxy-Lyases; Glutamates; Glutam | 1967 |
Modifications of brain glutamate decarboxylase activity by pyridoxal phosphate-gamma-glutamyl hydrazone.
Topics: Aminobutyrates; Animals; Brain; Carboxy-Lyases; Hydrazines; Mice; Phosphotransferases; Pyridoxal Pho | 1967 |
Formation of gamma-aminobutyric acid (GABA) in brain of mice treated with L-glutamic acid-gamma-hydrazide and pyridoxal phosphate-gamma-glutamyl hydrazone.
Topics: Aminobutyrates; Animals; Brain; Carbon Isotopes; Carboxy-Lyases; Chromatography, Paper; Glutamates; | 1967 |
Pyridoxal-5'-phosphate concentration as marker for vitamin-B6-dependent seizures in the newborn.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Middle Aged; Pyri | 1984 |
[Antiepileptic effects of complex therapy with vitamins and anticonvulsant preparations (experimental findings)].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Drug Therapy, Com | 1982 |
[Effect of vitamin preparations on epileptic activity].
Topics: Animals; Drug Evaluation, Preclinical; Drug Therapy, Combination; Epilepsy; Kindling, Neurologic; Mi | 1984 |
Synergistic inhibition of [3H]muscimol binding to calf-brain synaptic membranes in the presence of L-homocysteine and pyridoxal 5'-phosphate. A possible mechanism for homocysteine-induced seizures.
Topics: Animals; Binding, Competitive; Brain; Cattle; Drug Synergism; Homocysteine; In Vitro Techniques; Kin | 1983 |
[Use of nicotinamide and pyridoxal-5-phosphate to treat experimental epilepsy].
Topics: Animals; Cats; Drug Therapy, Combination; gamma-Aminobutyric Acid; Niacinamide; Penicillins; Pyridox | 1981 |
The effect of pyridoxal phosphate-induced convulsive seizures on rat brain phospholipid metabolism.
Topics: Animals; Brain; Diglycerides; Female; Glycerol; Injections, Intraventricular; Phosphatidic Acids; Ph | 1984 |
Uncontrollable convulsions responsive to pyridoxal phosphate in a uremic child.
Topics: Electroencephalography; Female; Humans; Infant; Kidney Failure, Chronic; Pyridoxal Phosphate; Seizur | 1984 |
Vitamin B6 intake and plasma pyridoxal phosphate concentrations in the first 2 weeks of life.
Topics: Bilirubin; Female; Humans; Infant Food; Infant Nutritional Physiological Phenomena; Infant, Newborn; | 1984 |
The selective inhibition of hippocampal glutamic acid decarboxylase in zinc-induced epileptic seizures.
Topics: Animals; Carboxy-Lyases; Glutamate Decarboxylase; Hippocampus; Male; Pyridoxal Phosphate; Rats; Rats | 1982 |
Pyridoxine as therapy in theophylline-induced seizures.
Topics: Aminophylline; Animals; Bronchodilator Agents; Disease Models, Animal; Electroencephalography; Femal | 1995 |
Seizures induced by theophylline and isoniazid in mice.
Topics: Animals; Antitubercular Agents; Bronchodilator Agents; Dose-Response Relationship, Drug; Female; Iso | 1999 |
Transient nonketotic hyperglycinemia in an asphyxiated patient with pyridoxine-dependent seizures.
Topics: Asphyxia Neonatorum; Brain; Electroencephalography; Glycine; Humans; Hyperglycinemia, Nonketotic; In | 2000 |
Pyridoxal phosphate de-activation by pyrroline-5-carboxylic acid. Increased risk of vitamin B6 deficiency and seizures in hyperprolinemia type II.
Topics: Aldehydes; Avitaminosis; Chromatography, High Pressure Liquid; Humans; Ketones; Magnetic Resonance S | 2001 |
Seizures induced by intracerebral administration of pyridoxal-5'-phosphate: effect of GABAergic drugs and glutamate receptor antagonists.
Topics: Animals; Electroencephalography; Excitatory Amino Acid Antagonists; GABA Agents; gamma-Aminobutyric | 2001 |
Gas chromatography-mass spectrometry analysis of 4-O-methylpyridoxine (MPN) in the serum of patients with ginkgo seed poisoning.
Topics: Antidotes; Chromatography, Gas; Female; Gas Chromatography-Mass Spectrometry; Ginkgo biloba; Humans; | 2002 |
Seizure susceptibility in the developing mouse and its relationship to glutamate decarboxylase and pyridoxal phosphate in brain.
Topics: Animals; Brain; Carboxy-Lyases; Convulsants; Glutamate Decarboxylase; Mice; Phosphotransferases; Pyr | 1975 |
On the mechanism of pyridoxal phosphate-related convulsions as implicated in enhanced transport of GABA.
Topics: Animals; Antimetabolites; Cerebral Cortex; gamma-Aminobutyric Acid; Male; Pyridoxal Kinase; Pyridoxa | 1979 |
[Therapeutic effectiveness of pyridoxine pyrrolidonecarboxylate in febrile convulsions in children].
Topics: Ammonia; Child, Preschool; Drug Evaluation; Female; Humans; Infant; Isonicotinic Acids; Male; Pyrido | 1977 |
Effects of prior administration of methionine sulfoximine on the thresholds of seizures induced in mice by 3-mercaptopropionic acid or pentylenetetrazol.
Topics: 3-Mercaptopropionic Acid; Animals; Drug Synergism; Glutamate Decarboxylase; Methionine Sulfoximine; | 1978 |
Evidence for a role of glutamate decarboxylase activity as a regulatory mechanism of cerebral excitability.
Topics: Aminobutyrates; Animals; Azides; Brain; Carboxy-Lyases; gamma-Aminobutyric Acid; Glutamate Decarboxy | 1975 |
The effect of castrix (2-chloro-4- dimethylamino-6-methylpyrimidine) on the distribution of B6 vitamers in mouse brain.
Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Isoniazid; Male; Mice; Penicillamine; Pyridoxa | 1976 |
[Effect of diazepam, carbamazepine, sodium valproate and their combinations with vitamin preparations on epileptic activity].
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Drug Therapy, Combination; Male; Niacinamide; Pen | 1985 |
A double inhibition kinetic analysis of [3H]-muscimol binding to the gamma-aminobutyric acid receptor on calf brain synaptic membranes. Further studies on the mechanism of homocysteine-induced seizures.
Topics: Animals; Binding, Competitive; Brain; Cattle; Drug Synergism; Homocysteine; Kinetics; Macromolecular | 1985 |
The effect of repeated electroconvulsive shock on GABA synthesis and release in regions of rat brain.
Topics: Animals; Brain; Electroshock; gamma-Aminobutyric Acid; Glutamate Decarboxylase; In Vitro Techniques; | 1987 |
Alteration of amino acid metabolism in epileptogenic mice by elevation of brain pyridoxal phosphate.
Topics: Acoustic Stimulation; Amino Acids; Animals; Brain; Mice; Mice, Inbred Strains; Pyridoxal Phosphate; | 1985 |
Anticonvulsant effect of 5-ethyl,5-phenyl,2-pyrrolidinone and its possible relationship to gamma-aminobutyric acid-dependent inhibitory mechanisms.
Topics: Aminobutyrates; Animals; Anticonvulsants; Behavior, Animal; Central Nervous System Stimulants; Drug | 1973 |
Effects of stimulants of the central nervous system on the pyridoxal phosphate content of the rat brain.
Topics: Amphetamine; Animals; Brain; Central Nervous System Stimulants; Injections, Intraperitoneal; Ipronia | 1965 |
A comparison of alkylhydrazines and their B 6-hydrazones as convulsant agents.
Topics: Animals; Central Nervous System Stimulants; Hydrazines; Mice; Pyridoxal Phosphate; Seizures | 1967 |
The influence of tyrosine, phenylpyruvate and vitamin B 6 upon seizure thresholds.
Topics: Amino Acids; Animals; Brain; Brain Chemistry; Central Nervous System Stimulants; Ethers; Fluorine; M | 1971 |
3-mercaptopropionic acid: convulsant and lethal properties compared with other sulfur-convulsants; protection therefrom.
Topics: Animals; Central Nervous System Stimulants; Glucose; Homocysteine; Lethal Dose 50; Male; Methionine | 1970 |
On the convulsive action of castrix.
Topics: Animals; Aspartate Aminotransferases; Carboxy-Lyases; Central Nervous System Stimulants; Cholinester | 1972 |
Susceptibility to thiosemicarbazide (an antagonist of vitamin B6), and phylogenetic and ontogenetic development of brain.
Topics: Age Factors; Animals; Animals, Newborn; Astacoidea; Behavior, Animal; Biological Evolution; Bombyx; | 1974 |
An examination of the role of gamma-aminobutyric acid (GABA) in hyperbaric oxygen-induced convulsions in the rat. II. Influence of metabolic cofactors.
Topics: Acetates; Aminobutyrates; Animals; Drug Synergism; Female; Hydrazines; Hyperbaric Oxygenation; Propi | 1974 |
Pyridoxal phosphate and glutamate decarboxylase in subcellular particles of mouse brain and their relationship to convulsions.
Topics: Animals; Brain; Carbon Isotopes; Carboxy-Lyases; Cytosol; Enzyme Activation; Glutamates; Hydrazines; | 1973 |
Anticonvulsant effect of 5-ethyl, 5-phenyl, 2-pyrrolidinone and its possible relationship to gamma-aminobutyric acid-dependent inhibitory mechanisms.
Topics: Alkaloids; Aminobutyrates; Animals; Anticonvulsants; Dioxoles; Hydrazones; Isoquinolines; Mice; Moto | 1973 |
-cyanoamino acids and related nitriles as inhibitors of glutamate decarboxylase.
Topics: Acetates; Amino Acids; Aminobutyrates; Animals; Carbon Isotopes; Carboxy-Lyases; Chickens; Cyanides; | 1971 |
The role of vitamin B6 in the toxicity of hydrazines.
Topics: Amino Acids; Animals; Brain Chemistry; Calcium; Hydrazines; Injections; Injections, Intraperitoneal; | 1969 |
Correlative changes of pyridoxal kinase pyridoxal-5'-phosphate and glutamate decarboxylase in brain, during drug-induced convulsions.
Topics: Acetates; Aminobutyrates; Animals; Brain; Brain Chemistry; Carboxy-Lyases; Glutamates; Hydrazines; M | 1969 |
Pyridoxine deficiency in the neonatal rat.
Topics: Age Factors; Alanine Transaminase; Animals; Animals, Newborn; Aspartate Aminotransferases; Body Weig | 1969 |
[Metabolic studies of epileptic seizures. Studies of glutamate metabolism in regions of the dog brain in preconvulsive states].
Topics: Alanine Transaminase; Amino Acids; Ammonia; Amygdala; Animals; Aspartate Aminotransferases; Brain; C | 1970 |
Mercaptopropionic acid: a convulsant that inhibits glutamate decarboxylase.
Topics: Animals; Brain; Carbon Isotopes; Carboxy-Lyases; Centrifugation; Hydrazines; In Vitro Techniques; In | 1970 |
The relationships between phenylalanine, phenylpyruvate, vitamin B-6 and seizure threshold.
Topics: Drug Antagonism; Phenylalanine; Phenylpyruvic Acids; Pyridoxal Phosphate; Pyridoxine; Seizures; Time | 1970 |
Relationships between pyridoxal phosphate availability, activity of vitamin B 6 -dependent enzymes and convulsions.
Topics: Alanine Transaminase; Aminobutyrates; Animals; Aspartate Aminotransferases; Brain; Carboxy-Lyases; D | 1971 |
Seizures in experimental porphyria.
Topics: Amides; Animals; Female; Isoniazid; Porphyrias; Porphyrins; Pyridoxal Phosphate; Pyridoxine; Rats; S | 1968 |
[Metabolic investigations of epileptic seizures. The activity of the glutamate decarboxylase prior to and during experimentally produced convulsions].
Topics: Animals; Aspartic Acid; Brain; Carboxy-Lyases; Electroshock; Female; Glutamates; In Vitro Techniques | 1968 |
Effects of various substituted hydrazones and hydrazines of pyridoxal-5'-phosphate on brain glutamate decarboxylase.
Topics: Animals; Brain; Carboxy-Lyases; Chemical Phenomena; Chemistry; Coenzymes; Depression, Chemical; Glut | 1969 |
[Metabolic studies on epileptic seizures. The activity of glutaminase and glutamine synthetase and ammonia metabolism before and during cerebral convulsions].
Topics: Ammonia; Animals; Brain; Glutaminase; Ligases; Pyridoxal Phosphate; Rats; Seizures | 1969 |
Vitamin B6 and the toxicity of 1,1-dimethylhydrazine.
Topics: Animals; Coenzymes; Hydrazines; Injections; Injections, Intraperitoneal; Male; Mortality; Pyridoxal | 1966 |