pyridoxal phosphate has been researched along with Pregnancy in 126 studies
Pyridoxal Phosphate: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
pyridoxal 5'-phosphate : The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This was a pre-specified substudy of a randomized, placebo-controlled trial comparing the antiemetic effect of the doxylamine-vitamin B6 combination (Diclectin®) (n = 131) to placebo (n = 126) in women with nausea and vomiting of pregnancy." | 9.19 | Studying the antiemetic effect of vitamin B6 for morning sickness: pyridoxine and pyridoxal are prodrugs. ( Caritis, S; Clark, S; Hankins, G; Koren, G; Matok, I; Mattison, DR; Miodovnik, M; Umans, JG, 2014) |
| "The effect of maternal pyridoxine X HCl (PN-HCl) supplementation on the vitamin B-6 status of pregnant women and their infants at birth and on pregnancy outcome was investigated." | 9.05 | Effect of maternal pyridoxine X HCl supplementation on the vitamin B-6 status of mother and infant and on pregnancy outcome. ( Bailey, LB; Mahan, CS; Schuster, K, 1984) |
| "Pyridoxine-dependent epilepsy (PDE) is a treatable inborn error of metabolism with autosomal recessive inheritance." | 7.77 | Status epilepticus in a neonate treated with pyridoxine because of a familial recurrence risk for antiquitin deficiency: pyridoxine toxicity? ( Fingerhut, M; Hartmann, H; Jakobs, C; Plecko, B, 2011) |
| "To evaluate the adequacy of maternal pyridoxine supplementation during pregnancy for both maternal and neonatal status at birth, vitamin B6 status, assessed by plasma pyridoxal phosphate (PLP), pyridoxal (PL) and total aldehyde vitamer (PLP + PL) concentrations, and the growth of neonates, including weight, length, head and chest circumferences, were examined for 209 neonates whose mothers were supplemented with 0, 1, 2 or 3 mg pyridoxine." | 7.70 | Adequacy of maternal pyridoxine supplementation during pregnancy in relation to the vitamin B6 status and growth of neonates at birth. ( Chang, SJ, 1999) |
| "The effect of different amounts of vitamin B6 supplementation during pregnancy on maternal and fetal plasma levels of pyridoxal phosphate (PLP) at term has been studied." | 7.65 | Maternal and fetal plasma levels of pyridoxal phosphate at term: adequacy of vitamin B6 supplementation during pregnancy. ( Cleary, RE; Li, TK; Lumeng, L, 1975) |
| ""Perinatal" hypophosphatasia is the most severe form of this inborn error of metabolism, which is characterized by deficient activity of the tissue-nonspecific (liver/bone/kidney) isoenzyme of alkaline phosphatase (ALP) (TNSALP)." | 5.27 | Perinatal hypophosphatasia: tissue levels of vitamin B6 are unremarkable despite markedly increased circulating concentrations of pyridoxal-5'-phosphate. Evidence for an ectoenzyme role for tissue-nonspecific alkaline phosphatase. ( Coburn, SP; Cole, FS; Fedde, KN; Mahuren, JD; McCabe, ER; Whyte, MP, 1988) |
| " This was a pre-specified substudy of a randomized, placebo-controlled trial comparing the antiemetic effect of the doxylamine-vitamin B6 combination (Diclectin®) (n = 131) to placebo (n = 126) in women with nausea and vomiting of pregnancy." | 5.19 | Studying the antiemetic effect of vitamin B6 for morning sickness: pyridoxine and pyridoxal are prodrugs. ( Caritis, S; Clark, S; Hankins, G; Koren, G; Matok, I; Mattison, DR; Miodovnik, M; Umans, JG, 2014) |
| "The delayed-release combination of doxylamine succinate and pyridoxine hydrochloride was the most commonly used antiemetic (Bendectin) approved by FDA for nausea and vomiting of pregnancy (NVP) until its removal of the market in 1983." | 5.14 | Pharmacokinetic comparison of a delayed-release combination of doxylamine succinate and pyridoxine hydrocholoride (Diclectin) and oral solutions of these drugs in healthy women of childbearing age. ( Koren, G; Nulman, I, 2009) |
| "The effect of maternal pyridoxine X HCl (PN-HCl) supplementation on the vitamin B-6 status of pregnant women and their infants at birth and on pregnancy outcome was investigated." | 5.05 | Effect of maternal pyridoxine X HCl supplementation on the vitamin B-6 status of mother and infant and on pregnancy outcome. ( Bailey, LB; Mahan, CS; Schuster, K, 1984) |
| "5, 4, and 10 mg of pyridoxine supplementation during pregnancy on maternal and fetal plasma levels of pyridoxal 5'-phosphate (PLP) and on the degree of coenzyme saturation (activation factor) of aspartate aminotransferase and alanine aminotransferase (alphaEGOT and alphaEGPT) in maternal erythrocytes." | 5.04 | Adequacy of vitamin B6 supplementation during pregnancy: a prospective study. ( Cleary, RE; Lumeng, L; Wagner, R, 1976) |
| "The aim of this study was to determine the relation between plasma PLP and cystathionine concentrations, and to assess longitudinal changes in plasma concentrations of metabolites of one-carbon metabolism, including total homocysteine (tHcy), cysteine, methionine, glycine, serine, and glutathione, over the course of pregnancy." | 3.91 | Maternal Plasma Pyridoxal 5'-Phosphate Concentration Is Inversely Associated with Plasma Cystathionine Concentration across All Trimesters in Healthy Pregnant Women. ( Farias, DR; Franco-Sena, AB; Kac, G; Lamers, Y; Mujica-Coopman, MF; Vaz, JS, 2019) |
| "To research the status of pyridoxal phosphate, folic acid, and cobalamin as part of an examination for hyperhomocysteinemia and to establish their relationship to the results of methionine challenge tests in women, who were tested at least 3 months after they had ended a pregnancy which was complicated by preeclampsia or other vascular-related pregnancy complications." | 3.77 | The reliability of methionine challenge test is not affected by a deficiency in pyridoxal phosphate, folic acid, or cobalamin. ( Bosma, JP; Klip, H; Nooij, LS; van de Leur, JJ; van Eyck, J, 2011) |
| "Diclectin, composed of 10 mg doxylamine succinate (DOX) and 10 mg pyridoxine hydrochloride, is the drug combination of choice for the management of nausea and vomiting during pregnancy in Canada." | 3.77 | Systemic bioavailability and pharmacokinetics of the doxylamine-pyridoxine delayed-release combination (Diclectin). ( Garcia-Bournissen, F; Gill, SK; Koren, G, 2011) |
| "Pyridoxine-dependent epilepsy (PDE) is a treatable inborn error of metabolism with autosomal recessive inheritance." | 3.77 | Status epilepticus in a neonate treated with pyridoxine because of a familial recurrence risk for antiquitin deficiency: pyridoxine toxicity? ( Fingerhut, M; Hartmann, H; Jakobs, C; Plecko, B, 2011) |
| "To evaluate the adequacy of maternal pyridoxine supplementation during pregnancy for both maternal and neonatal status at birth, vitamin B6 status, assessed by plasma pyridoxal phosphate (PLP), pyridoxal (PL) and total aldehyde vitamer (PLP + PL) concentrations, and the growth of neonates, including weight, length, head and chest circumferences, were examined for 209 neonates whose mothers were supplemented with 0, 1, 2 or 3 mg pyridoxine." | 3.70 | Adequacy of maternal pyridoxine supplementation during pregnancy in relation to the vitamin B6 status and growth of neonates at birth. ( Chang, SJ, 1999) |
| "The cause of reduced plasma pyridoxal-5'-phosphate (PLP) concentration and the validity of plasma PLP concentration as a vitamin B-6 status indicator during pregnancy are not well understood." | 3.68 | Vitamin B-6 status indices are lower in pregnant than in nonpregnant women but urinary excretion of 4-pyridoxic acid does not differ. ( Trumbo, PR; Wang, JW, 1993) |
| "The cause for reduced plasma pyridoxal phosphate (PLP) concentration during pregnancy is not well understood." | 3.68 | Bioavailability of vitamin B-6 in pregnant rats. ( Trumbo, PR; Wang, JW, 1992) |
| " Liver PLP content was also lower during pregnancy, but liver pyridoxamine 5'-phosphate (PMP), kidney PLP and PMP and muscle PLP contents did not change significantly." | 3.67 | Vitamin B-6 metabolism in the pregnant rat: effect of progesterone on the (re)distribution in maternal vitamin B-6 stores. ( Bogaards, JJ; Van den Berg, H, 1987) |
| "The vitamin B6 nutriture was determined during pregnancy beginning at month II until term by means of determination of pyridoxal phosphate in serum of 16 healthy pregnant women." | 3.66 | Vitamin B6 nutriture during pregnancy. ( Dapunt, O; Reinken, L, 1978) |
| "The effect of different amounts of vitamin B6 supplementation during pregnancy on maternal and fetal plasma levels of pyridoxal phosphate (PLP) at term has been studied." | 3.65 | Maternal and fetal plasma levels of pyridoxal phosphate at term: adequacy of vitamin B6 supplementation during pregnancy. ( Cleary, RE; Li, TK; Lumeng, L, 1975) |
| " Adverse events were reported for 23% of the patients; most were mild to moderate in intensity, did not require treatment, and were not drug related." | 2.69 | Safety and efficacy of mangafodipir trisodium (MnDPDP) injection for hepatic MRI in adults: results of the U.S. multicenter phase III clinical trials (safety). ( Anderson, MW; Borello, JA; Bova, JG; Brown, JJ; Chezmar, JL; Dachman, AH; Federle, MP; Fenstermacher, M; Foster, GS; Francis, IR; Freeny, PC; Halford, HH; Harmon, B; Harms, SE; Johnson, CD; Kenney, PJ; Klippenstein, DL; Lee, JK; Mattrey, R; Mitchell, DG; Pelsang, RE; Rubin, DL; Saini, S; Semelka, RC; Turner, DA; Weinreb, JC, 2000) |
| "The main pathogenic feature of preeclampsia is maternal endothelial dysfunction that results from impaired angiogenesis and reduced endothelial repair capacity." | 1.38 | Vitamin D improves the angiogenic properties of endothelial progenitor cells. ( Darashchonak, N; Grundmann, M; Haidar, M; Hubel, CA; Niendorf, R; Placzko, S; von Versen-Höynck, F, 2012) |
| " After a single intraperitoneal injection of low dosage with 0." | 1.35 | Manganese-enhanced MRI of hypoxic-ischemic brain injuries using Mn-DPDP. ( Wu, EX; Yang, J, 2009) |
| "The manganese (Mn) moiety is rapidly removed from plasma with an elimination half-life of less than 25 min in both species, reflecting a rapid distribution to the tissues and an early excretion." | 1.30 | Plasma pharmacokinetics, tissue distribution and excretion of MnDPDP in the rat and dog after intravenous administration. ( Grant, D; Hustvedt, SO; Southon, TE; Zech, K, 1997) |
| " Skeletal malformations, identical to those seen in the previous study, were increased in a dose-dependent manner with the highest incidence occurring in fetuses from females dosed from days 15-17 of gestation." | 1.29 | Developmental toxicity of mangafodipir trisodium and manganese chloride in Sprague-Dawley rats. ( Blazak, WF; Gray, TJ; Treinen, KA, 1995) |
| ""Perinatal" hypophosphatasia is the most severe form of this inborn error of metabolism, which is characterized by deficient activity of the tissue-nonspecific (liver/bone/kidney) isoenzyme of alkaline phosphatase (ALP) (TNSALP)." | 1.27 | Perinatal hypophosphatasia: tissue levels of vitamin B6 are unremarkable despite markedly increased circulating concentrations of pyridoxal-5'-phosphate. Evidence for an ectoenzyme role for tissue-nonspecific alkaline phosphatase. ( Coburn, SP; Cole, FS; Fedde, KN; Mahuren, JD; McCabe, ER; Whyte, MP, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 84 (66.67) | 18.7374 |
| 1990's | 22 (17.46) | 18.2507 |
| 2000's | 7 (5.56) | 29.6817 |
| 2010's | 12 (9.52) | 24.3611 |
| 2020's | 1 (0.79) | 2.80 |
| Authors | Studies |
|---|---|
| Bjørke-Monsen, AL | 1 |
| Varsi, K | 1 |
| Sakkestad, ST | 1 |
| Ulvik, A | 2 |
| Ueland, PM | 2 |
| Sáez-Orellana, F | 1 |
| Fuentes-Fuentes, MC | 1 |
| Godoy, PA | 1 |
| Silva-Grecchi, T | 1 |
| Panes, JD | 1 |
| Guzmán, L | 1 |
| Yévenes, GE | 1 |
| Gavilán, J | 1 |
| Egan, TM | 1 |
| Aguayo, LG | 1 |
| Fuentealba, J | 1 |
| Mujica-Coopman, MF | 1 |
| Farias, DR | 1 |
| Franco-Sena, AB | 1 |
| Vaz, JS | 1 |
| Kac, G | 1 |
| Lamers, Y | 1 |
| Shibata, K | 1 |
| Tachiki, A | 1 |
| Mukaeda, K | 1 |
| Fukuwatari, T | 1 |
| Sasaki, S | 1 |
| Jinno, Y | 1 |
| Matok, I | 1 |
| Clark, S | 1 |
| Caritis, S | 1 |
| Miodovnik, M | 1 |
| Umans, JG | 1 |
| Hankins, G | 1 |
| Mattison, DR | 1 |
| Koren, G | 3 |
| Sankaran, VG | 1 |
| Ulirsch, JC | 1 |
| Tchaikovskii, V | 1 |
| Ludwig, LS | 1 |
| Wakabayashi, A | 1 |
| Kadirvel, S | 1 |
| Lindsley, RC | 1 |
| Bejar, R | 1 |
| Shi, J | 1 |
| Lovitch, SB | 1 |
| Bishop, DF | 1 |
| Steensma, DP | 1 |
| Rios-Avila, L | 1 |
| Midttun, Ø | 1 |
| Gregory, JF | 1 |
| Taylor, CE | 1 |
| Li, T | 1 |
| Li, J | 1 |
| Liu, J | 1 |
| Zhang, P | 1 |
| Wu, W | 1 |
| Zhou, R | 1 |
| Li, G | 1 |
| Zhang, W | 1 |
| Yi, M | 1 |
| Huang, H | 1 |
| Li, F | 1 |
| Zhang, H | 1 |
| Wang, J | 1 |
| Yang, C | 1 |
| Nulman, I | 1 |
| Yang, J | 1 |
| Wu, EX | 1 |
| Liu, X | 1 |
| Hashimoto-Torii, K | 1 |
| Torii, M | 1 |
| Ding, C | 1 |
| Rakic, P | 1 |
| Nooij, LS | 1 |
| van Eyck, J | 1 |
| Klip, H | 1 |
| van de Leur, JJ | 1 |
| Bosma, JP | 1 |
| Gill, SK | 1 |
| Garcia-Bournissen, F | 1 |
| Hartmann, H | 1 |
| Fingerhut, M | 1 |
| Jakobs, C | 1 |
| Plecko, B | 1 |
| Grundmann, M | 1 |
| Haidar, M | 1 |
| Placzko, S | 1 |
| Niendorf, R | 1 |
| Darashchonak, N | 1 |
| Hubel, CA | 1 |
| von Versen-Höynck, F | 1 |
| WACHSTEIN, M | 1 |
| MOORE, C | 1 |
| GRAFFEO, LW | 1 |
| AKAYA, I | 1 |
| SHEID, B | 1 |
| MORRIS, HP | 1 |
| ROTH, JS | 1 |
| Ziganshin, AU | 1 |
| Zaitcev, AP | 1 |
| Khasanov, AA | 1 |
| Shamsutdinov, AF | 1 |
| Burnstock, G | 2 |
| Tamura, T | 1 |
| Munger, RG | 1 |
| Nepomuceno, B | 1 |
| Corcoran, C | 1 |
| Cembrano, J | 1 |
| Solon, F | 1 |
| Frimpter, GW | 1 |
| Greenberg, AJ | 1 |
| Hilgartner, M | 1 |
| Fuchs, F | 1 |
| DiPietro, DL | 1 |
| Zengerle, FS | 1 |
| Wilson, RG | 1 |
| Davis, RE | 1 |
| Smith, GP | 1 |
| Anderson, BB | 2 |
| Peters, TJ | 1 |
| Heidemann, E | 1 |
| Waller, HD | 1 |
| Dakshinamurti, K | 2 |
| Paulose, CS | 1 |
| Groziak, S | 1 |
| Kirksey, A | 3 |
| Hamaker, B | 1 |
| Schuster, K | 3 |
| Bailey, LB | 3 |
| Mahan, CS | 3 |
| Braunshteĭn, AE | 1 |
| Poulose, AJ | 1 |
| Rogers, L | 1 |
| Kolattukudy, PE | 1 |
| Lu, HS | 1 |
| Talent, JM | 1 |
| Gracy, RW | 1 |
| Shin, YS | 1 |
| Rasshofer, R | 1 |
| Friedrich, B | 1 |
| Endres, W | 1 |
| Atkins, JN | 1 |
| Shane, B | 6 |
| Brophy, MH | 2 |
| Sloger, MS | 2 |
| Reynolds, RD | 5 |
| Rao, VR | 1 |
| Iyengar, LR | 1 |
| Ejderhamn, J | 1 |
| Hamfelt, A | 3 |
| Jez, W | 1 |
| Kochański, L | 1 |
| Bartoszewska, J | 1 |
| Whyte, MP | 2 |
| Landt, M | 1 |
| Ryan, LM | 1 |
| Mulivor, RA | 1 |
| Henthorn, PS | 1 |
| Fedde, KN | 2 |
| Mahuren, JD | 3 |
| Coburn, SP | 3 |
| Tsuge, H | 1 |
| Maeno, M | 1 |
| Nagae, K | 1 |
| Nohisa, C | 1 |
| Hayakawa, T | 1 |
| Awata, S | 1 |
| Nakayama, K | 1 |
| Sato, A | 1 |
| Kawamura, M | 2 |
| Suzuki, I | 1 |
| Kodama, H | 1 |
| Trumbo, PR | 2 |
| Wang, JW | 2 |
| Chou, DK | 1 |
| Jungalwala, FB | 1 |
| Heiskanen, K | 1 |
| Siimes, MA | 1 |
| Salmenperä, L | 1 |
| Perheentupa, J | 1 |
| Treinen, KA | 2 |
| Gray, TJ | 2 |
| Blazak, WF | 3 |
| Link, G | 2 |
| Zempleni, J | 2 |
| Brown, GL | 2 |
| Denny, KH | 1 |
| Hustvedt, SO | 1 |
| Grant, D | 2 |
| Southon, TE | 1 |
| Zech, K | 1 |
| Ralevic, V | 1 |
| Burrell, S | 1 |
| Kingdom, J | 1 |
| Terzuoli, L | 1 |
| Leoncini, R | 1 |
| Pagani, R | 1 |
| Guerranti, R | 1 |
| Vannoni, D | 1 |
| Ponticelli, F | 1 |
| Marinello, E | 1 |
| Sánchez, DJ | 1 |
| Murphy, MM | 1 |
| Bosch-Sabater, J | 1 |
| Fernández-Ballart, J | 1 |
| Chang, SJ | 1 |
| Gehring, B | 1 |
| Mornet, E | 1 |
| Plath, H | 1 |
| Hansmann, M | 1 |
| Bartmann, P | 1 |
| Brenner, RE | 1 |
| Federle, MP | 1 |
| Chezmar, JL | 1 |
| Rubin, DL | 1 |
| Weinreb, JC | 1 |
| Freeny, PC | 1 |
| Semelka, RC | 1 |
| Brown, JJ | 1 |
| Borello, JA | 1 |
| Lee, JK | 1 |
| Mattrey, R | 1 |
| Dachman, AH | 1 |
| Saini, S | 1 |
| Harmon, B | 1 |
| Fenstermacher, M | 1 |
| Pelsang, RE | 1 |
| Harms, SE | 1 |
| Mitchell, DG | 1 |
| Halford, HH | 1 |
| Anderson, MW | 1 |
| Johnson, CD | 1 |
| Francis, IR | 1 |
| Bova, JG | 1 |
| Kenney, PJ | 1 |
| Klippenstein, DL | 1 |
| Foster, GS | 1 |
| Turner, DA | 1 |
| Watanabe, T | 1 |
| Nakamura, H | 1 |
| Liang, LY | 1 |
| Yamatodani, A | 1 |
| Wada, H | 1 |
| Rose, DP | 1 |
| Reinken, L | 3 |
| Dapunt, O | 1 |
| Prasad, AS | 1 |
| Lei, KY | 1 |
| Moghissi, KS | 1 |
| Stryker, JC | 1 |
| Oberleas, D | 1 |
| Lumeng, L | 2 |
| Cleary, RE | 2 |
| Wagner, R | 1 |
| Li, TK | 1 |
| Siiteri, PK | 1 |
| Pang, RL | 1 |
| Lin, WJ | 1 |
| Contractor, SF | 5 |
| Lancaster, GA | 1 |
| Mohyuddin, F | 1 |
| Scriver, CR | 1 |
| Dipaolo, RV | 2 |
| Spielvogel, C | 1 |
| Kanfer, JN | 2 |
| Riva, G | 1 |
| Uboldi, L | 1 |
| Bamji, MS | 1 |
| Kübler, W | 1 |
| Lo Bello, M | 1 |
| Petruzzelli, R | 1 |
| Reale, L | 1 |
| Ricci, G | 1 |
| Barra, D | 1 |
| Federici, G | 1 |
| Schenker, S | 1 |
| Johnson, RF | 1 |
| Henderson, GI | 1 |
| Leibman, D | 2 |
| Furth-Walker, D | 2 |
| Smolen, A | 2 |
| Moser-Veillon, PB | 2 |
| Chernyshov, VG | 1 |
| Agabekova, II | 1 |
| Lin, GW | 1 |
| Andon, MB | 2 |
| Howard, MP | 2 |
| Compton, MM | 1 |
| Cidlowski, JA | 1 |
| Martner-Hewes, PM | 1 |
| Hunt, IF | 1 |
| Murphy, NJ | 1 |
| Swendseid, ME | 1 |
| Settlage, RH | 1 |
| Ohno, H | 1 |
| Yamashita, K | 1 |
| Yorozu, Y | 1 |
| Mure, K | 1 |
| Kondo, T | 1 |
| Gasa, S | 1 |
| Ogle, TF | 1 |
| Cole, FS | 1 |
| McCabe, ER | 1 |
| Yates, CY | 1 |
| Boylan, LM | 1 |
| Lewis, RD | 1 |
| Driskell, JA | 3 |
| Barnard, HC | 1 |
| de Kock, JJ | 1 |
| Vermaak, WJ | 1 |
| Potgieter, GM | 1 |
| Van den Berg, H | 1 |
| Bogaards, JJ | 1 |
| Borschel, MW | 1 |
| Hannemann, RE | 1 |
| Dimperio, D | 1 |
| Leavitt, WW | 1 |
| Okulicz, WC | 1 |
| Moser, PB | 1 |
| Gaynor, R | 1 |
| Dempsey, WB | 1 |
| Naccarato, WF | 1 |
| Ray, RE | 1 |
| Wells, WW | 1 |
| Gant, H | 1 |
| Tuvemo, T | 1 |
| Kunze, E | 1 |
| Schauer, A | 1 |
| Aures, D | 1 |
| Gärtner, H | 1 |
| Strickland, LA | 1 |
| Poon, CH | 1 |
| Foshee, DP | 2 |
| Heinonen, K | 1 |
| Cheung, T | 1 |
| Briggs, MH | 1 |
| Caviness, VS | 1 |
| Maslinski, C | 2 |
| Niedzielski, A | 2 |
| György, P | 1 |
| Paolucci, F | 1 |
| Cronenberger, L | 1 |
| Plan, R | 1 |
| Pacheco, H | 1 |
| Srivastava, SK | 1 |
| Van Loon, C | 1 |
| Beutler, E | 1 |
| Krishnaswamy, K | 1 |
| Klieger, JA | 1 |
| Altshuler, CH | 1 |
| Krakow, G | 1 |
| Hollister, C | 1 |
| Stephens, MC | 1 |
| Peart, MB | 1 |
| Fulford-Jones, CE | 1 |
| Morohara, H | 1 |
| Lissitzky, S | 1 |
| Laurent, B | 1 |
| Bernard, P | 1 |
| Fenasse, R | 1 |
| Hahn, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double-Blind, Multicenter, Randomized, Placebo-Controlled Trial Of The Efficacy Of Diclectin® For Nausea And Vomiting Of Pregnancy[NCT00614445] | Phase 3 | 280 participants (Actual) | Interventional | 2008-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The objective of this double-blind, randomized, placebo-controlled study was to assess the efficacy, safety, and tolerability of oral Diclectin® in the treatment of nausea and vomiting of pregnancy (NVP) as measured by the Pregnancy Unique-Quantification of Emesis (PUQE) overall score of symptoms from baseline (Day 1) to end of study visit (Day 15). The PUQE score measured hours of nausea, number of times vomiting, and number of times retching for a TOTAL overall score of symptoms on a scale rated from 3 (no symptoms) to 15 (most severe). (NCT00614445)
Timeframe: Baseline (Day 1) to End of Study Visit Day 15 (± 1 day)
| Intervention | PUQE Score (Mean) |
|---|---|
| Diclectin® | -4.8 |
| Placebo | -3.9 |
10 reviews available for pyridoxal phosphate and Pregnancy
| Article | Year |
|---|---|
Direct and Functional Biomarkers of Vitamin B6 Status.
Topics: Amino Acids; Biomarkers; Body Mass Index; Female; Health Status; Humans; Infant; Infant, Newborn; In | 2015 |
Clinical chemistry of vitamin B6.
Topics: Animals; Biological Assay; Biological Availability; Biological Transport; Chemical Phenomena; Chemis | 1983 |
[Clinical significance of amino acid transformations as affected by pyridoxal phosphate enzymes].
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Amino Acids, Essential; Animals; Arteriosclerosis | 1982 |
The interactions between vitamin B6 and hormones.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Biogenic Amines; Brain; Contraceptives, Oral, | 1978 |
Requirement of vitamin B6 during pregnancy.
Topics: Contraceptives, Oral; Female; Fetal Blood; Humans; Mouth Diseases; Nutritional Requirements; Pregnan | 1976 |
Vitamin B6 and glucocorticoid action.
Topics: Animals; Borohydrides; Caseins; Cell Line; Cell Nucleus; Centrifugation, Density Gradient; Chemical | 1986 |
[Scope and effect of vitamin B6 in newborn infants and children].
Topics: Amino Acids; Anemia, Hypochromic; Aspartate Aminotransferases; Brain; Coenzymes; Drug Antagonism; Fe | 1974 |
Metabolism of vitamin B 6 in the pregnant rat.
Topics: Animals; Biological Transport; Carbon Isotopes; Chromatography, Ion Exchange; Diet; Female; Fetus; M | 1972 |
Vitamin B 6 deficiency and brain lipids in the suckling rat.
Topics: Animals; Brain; Cholesterol; Female; Glycolipids; Lipid Metabolism; Liver; Myelin Sheath; Phospholip | 1972 |
Developments leading to the metabolic role of vitamin B 6.
Topics: Acrodynia; Adult; Aged; Aging; Amines; Animals; Arteriosclerosis; Aspartate Aminotransferases; Biolo | 1971 |
8 trials available for pyridoxal phosphate and Pregnancy
| Article | Year |
|---|---|
Studying the antiemetic effect of vitamin B6 for morning sickness: pyridoxine and pyridoxal are prodrugs.
Topics: Antiemetics; Delayed-Action Preparations; Dicyclomine; Double-Blind Method; Doxylamine; Drug Combina | 2014 |
Pharmacokinetic comparison of a delayed-release combination of doxylamine succinate and pyridoxine hydrocholoride (Diclectin) and oral solutions of these drugs in healthy women of childbearing age.
Topics: Adult; Antiemetics; Area Under Curve; Biological Availability; Cross-Over Studies; Delayed-Action Pr | 2009 |
Effect of maternal pyridoxine X HCl supplementation on the vitamin B-6 status of mother and infant and on pregnancy outcome.
Topics: Apgar Score; Aspartate Aminotransferases; Dose-Response Relationship, Drug; Female; Fetal Blood; Hum | 1984 |
Safety and efficacy of mangafodipir trisodium (MnDPDP) injection for hepatic MRI in adults: results of the U.S. multicenter phase III clinical trials (safety).
Topics: Abdominal Pain; Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Contrast Media; Diagnosis, | 2000 |
Adequacy of vitamin B6 supplementation during pregnancy: a prospective study.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Clinical Enzyme Tests; Erythrocytes; Female; Feta | 1976 |
A longitudinal study of pyridoxine and zinc supplementation of lactating women.
Topics: Adult; Diet; Erythrocytes; Female; Humans; Lactation; Longitudinal Studies; Milk, Human; Nutritional | 1990 |
Maternal aerobic exercise and vitamin B-6 status.
Topics: Diet; Female; Humans; Osmolar Concentration; Physical Exertion; Pregnancy; Pregnancy Outcome; Pyrido | 1988 |
Nutritionally relevant supplementation of vitamin B6 in lactating women: effect on plasma prolactin.
Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Lactation; Milk, Human | 1985 |
108 other studies available for pyridoxal phosphate and Pregnancy
| Article | Year |
|---|---|
Assessment of vitamin B6 status in never-pregnant, pregnant and postpartum women and their infants.
Topics: Female; Humans; Infant; Lactation; Postpartum Period; Pregnancy; Prospective Studies; Pyridoxal Phos | 2023 |
P2X receptor overexpression induced by soluble oligomers of amyloid beta peptide potentiates synaptic failure and neuronal dyshomeostasis in cellular models of Alzheimer's disease.
Topics: Adenosine Triphosphate; Amyloid beta-Peptides; Animals; Cell Survival; Cells, Cultured; Cerebral Cor | 2018 |
Maternal Plasma Pyridoxal 5'-Phosphate Concentration Is Inversely Associated with Plasma Cystathionine Concentration across All Trimesters in Healthy Pregnant Women.
Topics: Adult; Cystathionine; Female; Humans; Pregnancy; Pregnancy Trimesters; Prospective Studies; Pyridoxa | 2019 |
Changes in plasma pyridoxal 5'-phosphate concentration during pregnancy stages in Japanese women.
Topics: Adult; Asian People; Biomarkers; Diet; Female; Humans; Japan; Maternal Nutritional Physiological Phe | 2013 |
X-linked macrocytic dyserythropoietic anemia in females with an ALAS2 mutation.
Topics: 5-Aminolevulinate Synthetase; Adult; Anemia, Dyserythropoietic, Congenital; Anemia, Macrocytic; Cell | 2015 |
A novel treatment for "morning sickness": Nausea of pregnancy could be induced by excess sulfite which molybdenum can help alleviate.
Topics: Catalysis; Female; Humans; Hydrogen Sulfide; Models, Theoretical; Molybdenum; Morning Sickness; Naus | 2016 |
Polymerized placenta hemoglobin attenuates ischemia/reperfusion injury and restores the nitroso-redox balance in isolated rat heart.
Topics: Animals; Apoptosis; Female; Heart Function Tests; Heart Transplantation; Hemoglobins; Humans; Hydrog | 2009 |
Purification and viral inactivation of hemoglobin from human placenta blood.
Topics: Biochemistry; Blood Chemical Analysis; Blood Substitutes; Clinical Trials as Topic; Cost-Benefit Ana | 2009 |
Manganese-enhanced MRI of hypoxic-ischemic brain injuries using Mn-DPDP.
Topics: Animals; Animals, Newborn; Contrast Media; Edetic Acid; Female; Hypoxia-Ischemia, Brain; Magnetic Re | 2009 |
Gap junctions/hemichannels modulate interkinetic nuclear migration in the forebrain precursors.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphate; Animals; Boron Compounds; | 2010 |
The reliability of methionine challenge test is not affected by a deficiency in pyridoxal phosphate, folic acid, or cobalamin.
Topics: Adult; Female; Folic Acid; Folic Acid Deficiency; Humans; Hyperhomocysteinemia; Methionine; Pregnanc | 2011 |
Systemic bioavailability and pharmacokinetics of the doxylamine-pyridoxine delayed-release combination (Diclectin).
Topics: Adult; Antiemetics; Biological Availability; Canada; Delayed-Action Preparations; Dicyclomine; Doxyl | 2011 |
Status epilepticus in a neonate treated with pyridoxine because of a familial recurrence risk for antiquitin deficiency: pyridoxine toxicity?
Topics: Adult; Aldehyde Dehydrogenase; Epilepsy; Female; Humans; Infant; Infant, Newborn; Infusions, Parente | 2011 |
Vitamin D improves the angiogenic properties of endothelial progenitor cells.
Topics: Angiogenesis Inhibitors; Cell Proliferation; Cells, Cultured; Cholecalciferol; Endothelial Cells; Fe | 2012 |
Pyridoxal phosphate (B6-al-PO4) levels of circulating leukocytes in maternal and cord blood.
Topics: Female; Fetal Blood; Humans; Leukocytes; Pregnancy; Pyridoxal Phosphate | 1957 |
[Effect of Pydoxal injections on pregnancy complications].
Topics: Female; Humans; Injections; Pregnancy; Pregnancy Complications; Pyridoxal Phosphate | 1963 |
HISTIDINE DECARBOXYLASE IN THE FETAL RAT.
Topics: Carboxy-Lyases; Chemistry Techniques, Analytical; Female; Fetus; Histidine; Histidine Decarboxylase; | 1963 |
DISTRIBUTION AND ACTIVITY OF ASPARTATE AMINOTRANSFERASE IN SOME RAPIDLY PROLIFERATING TISSUES.
Topics: Animals; Aspartate Aminotransferases; Electrophoresis; Embryo, Mammalian; Embryo, Nonmammalian; Huma | 1965 |
Term-dependency of P2 receptor-mediated contractile responses of isolated human pregnant uterus.
Topics: Adenosine Triphosphate; Electric Stimulation; Female; Humans; In Vitro Techniques; Myometrium; Pregn | 2006 |
Maternal plasma pyridoxal-5'-phosphate concentrations and risk of isolated oral clefts in the Philippines.
Topics: Adult; Aspartate Aminotransferases; Case-Control Studies; Cleft Lip; Cleft Palate; Female; Humans; M | 2007 |
Cystathioninuria: management.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Amino Acids; Amniotic Fluid; Child; Child, Preschool; C | 1967 |
Separation and properties of three acid phosphatases from human placenta.
Topics: Acid Phosphatase; Centrifugation; Chromatography; Chromatography, Gel; Enzymes; Esterases; Female; H | 1967 |
Levels and subcellular localisation of pyridoxal and pyridoxal phosphate in human polymorphonuclear leukocytes and their relationship to alkaline phosphatase activity.
Topics: Alkaline Phosphatase; Cell Fractionation; Centrifugation, Density Gradient; Cytosol; Female; Humans; | 1983 |
[Disorders of erythropoiesis and the immune system caused by alcohol. 1. Erythropoiesis].
Topics: Acid Phosphatase; Alcoholism; Anemia; Bone Marrow Cells; Erythrocyte Indices; Erythropoiesis; Female | 1983 |
Consequences of decreased brain serotonin in the pyridoxine-deficient young rat.
Topics: Animals; Brain; Cerebral Cortex; Corpus Striatum; Dopamine; Female; Pregnancy; Pyridoxal Phosphate; | 1983 |
Effect of maternal vitamin B-6 restriction on pyridoxal phosphate concentrations in developing regions of the central nervous system in rats.
Topics: Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Body Weight; Brain; Central N | 1984 |
Selective chemical modification of the active sites of the ketoacyl reductase and enoyl reductase of fatty acid synthetase from lactating rat mammary glands.
Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Reductase; Acyl Carrier Protein; Alcohol Oxidoreductases; Animals; | 1980 |
Chemical modification of critical catalytic residues of lysine, arginine, and tryptophan in human glucose phosphate isomerase.
Topics: Affinity Labels; Arginine; Bromosuccinimide; Circular Dichroism; Cyclohexanones; Diacetyl; Female; G | 1981 |
Pyridoxal-5'-phosphate determination by a sensitive micromethod in human blood, urine and tissues; its relation to cystathioninuria in neuroblastoma and biliary atresia.
Topics: Adolescent; Adult; Bile Ducts; Brain Chemistry; Child; Child, Preschool; Cystathionine; Female; Fetu | 1983 |
Maternal plasma concentration of pyridoxal phosphate during pregnancy: adequacy of vitamin B6 supplementation during isoniazid therapy.
Topics: Female; Humans; Isoniazid; Pregnancy; Pregnancy Complications; Pregnancy Complications, Infectious; | 1982 |
Vitamin B-6 metabolism and turnover in the ethanol-fed rat.
Topics: Alcoholism; Animals; Body Weight; Brain; Female; Humans; Liver; Male; Organ Size; Organophosphorus C | 1982 |
Vitamin B-6 and plasma PLP in pregnancy, lactation.
Topics: Animals; Copper; Female; Humans; Lactation; Pregnancy; Pyridoxal Phosphate; Pyridoxine; Rats | 1981 |
Pyridoxal 5'-phosphate in whole blood, plasma and blood cells of postpartum nonlactating and lactating rats and their pups.
Topics: Animals; Diet; Erythrocytes; Female; Hematocrit; Lactation; Male; Postpartum Period; Pregnancy; Pyri | 1981 |
Vitamin B6 status of low-income adolescent and adult pregnant women and the condition of their infants at birth.
Topics: Adolescent; Adult; Alanine Transaminase; Apgar Score; Birth Weight; Diet; Erythrocytes; Female; Huma | 1981 |
Erythrocyte glutamate transaminase levels in normal and pre-eclamptic pregnancies.
Topics: Aspartate Aminotransferases; Erythrocytes; Female; Humans; Pre-Eclampsia; Pregnancy; Pregnancy Trime | 1981 |
Pyridoxal phosphate concentration in blood in newborn infants and their mothers compared with the amount of extra pyridoxol taken during pregnancy and breast feeding.
Topics: Adolescent; Adult; Breast Feeding; Female; Fetal Blood; Humans; Infant, Newborn; Pregnancy; Pyridoxa | 1980 |
[Activity of glucosephosphate isomerase (PHI) and the content of pyridoxal phosphate (PAL) in the blood serum in early puerperium].
Topics: Female; Glucose-6-Phosphate Isomerase; Humans; Postpartum Period; Pregnancy; Pyridoxal Phosphate; Ti | 1980 |
Effects of pregnancy and lactation on pyridoxal 5'-phosphate in plasma, blood and liver of rats fed three levels of vitamin B-6.
Topics: Animals; Female; Lactation; Liver; Male; Plasma; Pregnancy; Pregnancy, Animal; Pyridoxal Phosphate; | 1980 |
Alkaline phosphatase: placental and tissue-nonspecific isoenzymes hydrolyze phosphoethanolamine, inorganic pyrophosphate, and pyridoxal 5'-phosphate. Substrate accumulation in carriers of hypophosphatasia corrects during pregnancy.
Topics: Alkaline Phosphatase; Diphosphates; Ethanolamines; Female; Heterozygote; Humans; Hypophosphatasia; I | 1995 |
Change in blood levels of vitamin B-6 derivatives in pregnant and lactating rats.
Topics: Animals; Chromatography, High Pressure Liquid; Erythrocytes; Female; Lactation; Nutritional Status; | 1994 |
Changes in cystathionine gamma-lyase levels in rat liver during lactation.
Topics: Animals; Antibodies, Monoclonal; Cystathionine gamma-Lyase; Electrophoresis, Polyacrylamide Gel; Enz | 1993 |
Vitamin B-6 status indices are lower in pregnant than in nonpregnant women but urinary excretion of 4-pyridoxic acid does not differ.
Topics: Adult; Alkaline Phosphatase; Aspartate Aminotransferases; Chromatography, High Pressure Liquid; Eryt | 1993 |
Characterization and developmental expression of a novel sulfotransferase for the biosynthesis of sulfoglucuronyl glycolipids in the nervous system.
Topics: Aging; Animals; Brain; Carbohydrate Sequence; Cerebellum; Cerebral Cortex; Chromatography, Affinity; | 1993 |
Low vitamin B6 status associated with slow growth in healthy breast-fed infants.
Topics: Anthropometry; Birth Weight; Blood Proteins; Body Height; Breast Feeding; Female; Follow-Up Studies; | 1995 |
Developmental toxicity of mangafodipir trisodium and manganese chloride in Sprague-Dawley rats.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Chlorides; Contrast Media; Dose-Response Relat | 1995 |
Intrauterine elimination of pyridoxal 5'-phosphate in full-term and preterm infants.
Topics: Adult; Blood Flow Velocity; Female; Humans; Infant, Newborn; Infant, Premature; Pregnancy; Pyridoxal | 1996 |
Developmental toxicity study of mangafodipir trisodium injection (MnDPDP) in New Zealand white rabbits.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Contrast Media; Edetic Acid; Embryonic and Fetal | 1996 |
Plasma pharmacokinetics, tissue distribution and excretion of MnDPDP in the rat and dog after intravenous administration.
Topics: Animals; Carbon Radioisotopes; Contrast Media; Dogs; Edetic Acid; Female; Half-Life; Injections, Int | 1997 |
The reproductive toxicology of intravenously administered MnDPDP in the rat and rabbit.
Topics: Abnormalities, Drug-Induced; Animals; Contrast Media; Dose-Response Relationship, Drug; Edetic Acid; | 1997 |
Characterization of P2 receptors for purine and pyrimidine nucleotides in human placental cotyledons.
Topics: Adenosine Triphosphate; Adult; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; NG-Nitroarg | 1997 |
Some chemical properties and biological role of thiazolidine compounds.
Topics: Animals; Bacteria; Cysteamine; Cysteine; Female; Magnetic Resonance Spectroscopy; Male; Pregnancy; P | 1998 |
Enzymic evaluation of thiamin, riboflavin and pyridoxine status of parturient mothers and their newborn infants in a Mediterranean area of Spain.
Topics: Adolescent; Adult; Aspartate Aminotransferases; Female; Fetal Blood; Flavin-Adenine Dinucleotide; Gl | 1999 |
Adequacy of maternal pyridoxine supplementation during pregnancy in relation to the vitamin B6 status and growth of neonates at birth.
Topics: Dietary Supplements; Female; Fetal Blood; Humans; Infant, Newborn; Nutritional Status; Pregnancy; Py | 1999 |
Perinatal hypophosphatasia: diagnosis and detection of heterozygote carriers within the family.
Topics: Alkaline Phosphatase; Family Health; Female; Fetal Blood; Heterozygote; Humans; Hypophosphatasia; In | 1999 |
Partial purification and characterization of L-histidine decarboxylase from fetal rats.
Topics: Ammonium Sulfate; Animals; Carboxy-Lyases; Chemical Fractionation; Chromatography, Affinity; Chromat | 1979 |
Vitamin B6 nutriture during pregnancy.
Topics: Birth Weight; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pregnancy; Pregnancy Complic | 1978 |
Effect of oral contraceptives on nutrients. III. Vitamins B6, B12, and folic acid.
Topics: Adolescent; Adult; Aspartate Aminotransferases; Contraceptives, Oral; Contraceptives, Oral, Syntheti | 1976 |
Maternal and fetal plasma levels of pyridoxal phosphate at term: adequacy of vitamin B6 supplementation during pregnancy.
Topics: Adult; Blood Specimen Collection; Circadian Rhythm; Female; Fetus; Humans; Infant, Newborn; Maternal | 1975 |
Pyridoxal phosphate and hypertensive disorders of pregnancy.
Topics: Administration, Oral; Brain; Female; Fetus; Growth; Humans; Hypertension; Infant, Newborn; Injection | 1975 |
Effects of different levels of pyridoxine fed during pregnancy superimposed upon growth in the rat.
Topics: Age Factors; Alanine Transaminase; Animal Nutritional Physiological Phenomena; Animals; Body Weight; | 1975 |
Assessment of vitamin B 6 status. Studies on pregnant women and oral contraceptive users.
Topics: Adolescent; Adult; Aspartate Aminotransferases; Clinical Enzyme Tests; Contraceptives, Oral; Enzyme | 1975 |
Ontogeny of L-glutamic acid decarboxylase and gamma-aminobutyric acid concentration in human kidney.
Topics: Age Factors; Aminobutyrates; Autopsy; Carboxy-Lyases; Chromatography, Ion Exchange; Female; Fetus; G | 1975 |
Increased lysosomal hydrolase activity in kidney and brain from the vitamin B6-deficient developing rat.
Topics: Acid Phosphatase; alpha-L-Fucosidase; Animals; Blood Urea Nitrogen; Brain; Female; Galactosidases; G | 1975 |
[Toxicity of 3 antibiotics (amoxicillin, cephalexin, methacyclin) in pregnancy in experimental animals subjected to mild pyridoxine deficiency].
Topics: Animals; Anti-Bacterial Agents; Blood; Body Weight; Female; Fetus; Liver; Pregnancy; Pregnancy Compl | 1975 |
Enzymic evaluation of thiamin, riboflavin and pyridoxine status of parturient women and their newborn infants.
Topics: Aspartate Aminotransferases; Erythrocytes; Female; Fetal Blood; Glutathione Reductase; Humans; India | 1976 |
Bioavailability of vitamin B-6 in pregnant rats.
Topics: Animals; Biological Availability; Erythrocytes; Female; Intestinal Absorption; Pregnancy; Pregnancy, | 1992 |
The transport of thiamine, riboflavin and pyridoxal 5'-phosphate by human placenta.
Topics: Adolescent; Adult; Biological Transport; Chromatography, High Pressure Liquid; Female; Humans; Place | 1992 |
Chemical modification of human placental glutathione transferase by pyridoxal 5'-phosphate.
Topics: Amino Acid Sequence; Binding Sites; Chromatography, High Pressure Liquid; Female; Glutathione Transf | 1992 |
Human placental vitamin B6 (pyridoxal) transport: normal characteristics and effects of ethanol.
Topics: Biological Transport; Biological Transport, Active; Ethanol; Female; Humans; Maternal-Fetal Exchange | 1992 |
Vitamin B-6 metabolic enzymes in blood and placenta of pregnant mice.
Topics: Alkaline Phosphatase; Animals; Erythrocytes; Female; Hydrogen-Ion Concentration; Intestines; Kidney; | 1990 |
[Relation between erythrocyte saturation with vitamins B2 and B6 in anemic patients and degree of cell maturity].
Topics: Anemia; Erythrocytes; Female; Humans; Pregnancy; Pregnancy Complications, Hematologic; Pyridoxal Pho | 1987 |
Effect of ethanol and vitamin B6 deficiency on pyridoxal 5-phosphate levels and fetal growth in rat.
Topics: Animals; Diet; Embryonic and Fetal Development; Ethanol; Female; Fetus; Pregnancy; Pyridoxal Phospha | 1989 |
Changes in pyridoxal phosphate and pyridoxamine phosphate in blood, liver and brain in the pregnant mouse.
Topics: Animals; Brain; Erythrocytes; Female; Liver; Methods; Mice; Osmolar Concentration; Pregnancy; Pregna | 1989 |
Dietary intake of total and glycosylated vitamin B-6 and the vitamin B-6 nutritional status of unsupplemented lactating women and their infants.
Topics: Adult; Breast Feeding; Diet; Female; Glucosides; Humans; Infant; Lactation; Milk, Human; Nutritional | 1989 |
Vitamin B-6 nutriture and plasma diamine oxidase activity in pregnant Hispanic teenagers.
Topics: Adolescent; Alanine Transaminase; Amine Oxidase (Copper-Containing); Female; Hispanic or Latino; Hum | 1986 |
Apoenzyme of aspartate aminotransferase isoenzymes in maternal plasma during labor and following delivery.
Topics: Adult; Apoenzymes; Apoproteins; Aspartate Aminotransferases; Creatine Kinase; Female; Humans; Isoenz | 1988 |
Nuclear acceptor sites for progesterone-receptor complexes in rat placenta.
Topics: Animals; Cell Nucleus; Chloroquine; Dactinomycin; Deoxyribonucleases; Female; Peptide Hydrolases; Pl | 1987 |
Perinatal hypophosphatasia: tissue levels of vitamin B6 are unremarkable despite markedly increased circulating concentrations of pyridoxal-5'-phosphate. Evidence for an ectoenzyme role for tissue-nonspecific alkaline phosphatase.
Topics: Alkaline Phosphatase; Female; Fetal Death; Humans; Hypophosphatasia; Infant, Newborn; Male; Pregnanc | 1988 |
A new perspective in the assessment of vitamin B-6 nutritional status during pregnancy in humans.
Topics: Adolescent; Adult; Black People; Female; Humans; Nutritional Status; Pregnancy; Pyridoxal; Pyridoxal | 1987 |
Vitamin B-6 metabolism in the pregnant rat: effect of progesterone on the (re)distribution in maternal vitamin B-6 stores.
Topics: Animals; Female; Kidney; Liver; Muscles; Organ Size; Ovariectomy; Pregnancy; Pregnancy, Animal; Prog | 1987 |
Effects of vitamin B6 intake on nutriture and growth of young infants.
Topics: Body Height; Body Weight; Female; Fetal Blood; Growth; Humans; Infant; Infant Nutritional Physiologi | 1986 |
Morning sickness and vitamin B6 status of pregnant women.
Topics: Adolescent; Adult; Aspartate Aminotransferases; Erythrocytes; Female; Humans; Nausea; Pregnancy; Pre | 1985 |
Progesterone control of nuclear estrogen receptor: demonstration in hamster uterus during the estrous cycle and pseudopregnancy using a new exchange assay.
Topics: Animals; Cell Nucleus; Chemical Phenomena; Chemistry; Cricetinae; Cytosol; Estrus; Female; Indicator | 1985 |
Vitamin B 6 enzymes in normal and pre-eclamptic human placentae.
Topics: Alcohol Oxidoreductases; Ammonium Sulfate; Chemical Precipitation; Eclampsia; Female; Humans; Phosph | 1972 |
Biosynthesis of myo-inositol in rat mammary gland. Isolation and properties of the enzymes.
Topics: Ammonia; Animals; Benzenesulfonates; Carbohydrate Epimerases; Chromatography, Gel; Female; Fructosep | 1974 |
Vitamin B6 nutrition in women with hyperemesis gravidarum during the first trimester of pregnancy.
Topics: Female; Humans; Hyperemesis Gravidarum; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, | 1974 |
Pyridoxal phosphate and folic acid concentration in blood and erythrocyte aspartate aminotransferase activity during pregnancy.
Topics: Aspartate Aminotransferases; Erythrocytes; Female; Folic Acid; Gestational Age; Humans; Infant, Newb | 1972 |
Influence of cortisol-21-hemisuccinate on the specific histidine decarboxylase of the fetal rat liver.
Topics: Animals; Animals, Newborn; Body Weight; Carbon Dioxide; Carbon Isotopes; Carboxy-Lyases; Female; Fet | 1972 |
The vitamin B 6 requirement of the male rat as determined by behavioral patterns, brain pyridoxal phosphate and nucleic acid composition and erythrocyte alanine aminotransferase activity.
Topics: Age Factors; Alanine Transaminase; Animals; Behavior, Animal; Brain; DNA; Dose-Response Relationship | 1973 |
Studies on cystathionase activity in rat liver and brain during development. Effects of hormones and amino acids in vivo.
Topics: Animals; Animals, Newborn; Brain; Cystathionine; Female; Fetus; Homoserine; Liver; Lyases; Methionin | 1973 |
Behavioral patterns and brain nucleic acid and pyridoxal phosphate contents of male rat progeny from vitamin B-6-repleted dams.
Topics: Animals; Auditory Perception; Behavior, Animal; Brain; DNA; Exploratory Behavior; Female; Gestationa | 1974 |
Pyridoxal phosphate and the measurement of aminotransferase activity.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Binding Sites; Cardiac Surgical Procedures; Diabe | 1974 |
Delayed maturation of the renal cortex in the vitamin B6-deficient newborn rat.
Topics: Animals; Blood Urea Nitrogen; Body Weight; Brain Chemistry; Cerebral Hemorrhage; Female; Kidney Cort | 1974 |
[Inhibition of histidine decarboxylase. A fetal signal announcing parturition in mice].
Topics: Animals; Carboxy-Lyases; Female; Fetus; Guanidines; Histidine; Hydrazines; Hydrogen-Ion Concentratio | 1968 |
[Purification and properties of diamine: oxygen oxidoreductase from human placenta].
Topics: Amine Oxidase (Copper-Containing); Amines; Chromatography, Gel; Female; Hemoglobins; Humans; Hydroge | 1971 |
Characterization of a previously unidentified hemoglobin fraction.
Topics: Adult; Age Factors; Binding Sites; Blood; Chromatography, Ion Exchange; Erythrocytes; Female; Fetal | 1972 |
Erythrocyte glutamic oxaloacetic transaminase activity in patients with oral lesions.
Topics: Aspartate Aminotransferases; Cheilitis; Erythrocytes; Female; Glossitis; Humans; Male; Metabolism; M | 1971 |
Metabolism of [14C] pyridoxol in the pregnant rat.
Topics: Animals; Brain Chemistry; Carbon Isotopes; Cellulose; Chromatography; Female; Fetus; Kidney; Liver; | 1971 |
Abnormal pyridoxine metabolism in toxemia of pregnancy.
Topics: Brain; Brain Chemistry; Female; Humans; Kidney; Liver; Phosphotransferases; Placenta; Pre-Eclampsia; | 1969 |
Pyridoxine deficiency in the neonatal rat.
Topics: Age Factors; Alanine Transaminase; Animals; Animals, Newborn; Aspartate Aminotransferases; Body Weig | 1969 |
The measurement of serum pyridoxal by a microbiological assay using Lactobacillus casei.
Topics: Adolescent; Adult; Age Factors; Aged; Anemia, Sideroblastic; Arthritis, Rheumatoid; Biological Assay | 1970 |
Blood and urine levels of vitamin B6 in the mother and fetus before and after loading of the mother with vitamin B6.
Topics: Adult; Female; Humans; Infant, Newborn; Injections, Intravenous; Intestinal Absorption; Male; Matern | 1970 |
4-pyridoxic acid 5'-phosphate: a metabolite of pyridoxol in the rat.
Topics: Animals; Carbon Isotopes; Chromatography; Chromatography, DEAE-Cellulose; Chromatography, Thin Layer | 1970 |
[Study of management of lung immaturity].
Topics: Animals; Female; Flavin-Adenine Dinucleotide; Glucocorticoids; Humans; Hydroxocobalamin; Infant, New | 1967 |
Histidine decarboxylase in mouse foetal tissues. II. Physiological role of the enzyme in delivery.
Topics: Animals; Carboxy-Lyases; Delivery, Obstetric; Female; Fetus; Histamine; Histidine; Hydrazines; Isoqu | 1969 |
[Experimental studies in a case of tyrosinosis. New pathogenic hypothesis].
Topics: Adult; Amino Acids; Animals; Blood Glucose; Carbon Dioxide; Chromatography; Depression, Chemical; Di | 1969 |
Pyridoxal phosphate concentration in plasma and tryptophan load test during pregnancy.
Topics: Adult; Chromatography, Thin Layer; Estrogens; Female; Humans; Pregnancy; Pyridoxal Phosphate; Time F | 1969 |
Pyridoxal kinase in the human placenta and foetus through gestation.
Topics: Adenosine Triphosphate; Chemical Phenomena; Chemistry; Cyanides; Delivery, Obstetric; Female; Fluoro | 1969 |