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pyridoxal phosphate and Multiple Sclerosis

pyridoxal phosphate has been researched along with Multiple Sclerosis in 2 studies

Pyridoxal Phosphate: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
pyridoxal 5'-phosphate : The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.

Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)

Research Excerpts

ExcerptRelevanceReference
"Cuprizone intoxication is a common animal model used to test myelin regenerative therapies for the treatment of diseases such as multiple sclerosis."3.85Cuprizone Intoxication Induces Cell Intrinsic Alterations in Oligodendrocyte Metabolism Independent of Copper Chelation. ( Avila, R; Caporoso, J; Huang, H; Leeper, TC; Manandhar, E; Medicetty, S; Modarelli, DA; Shriver, LP; Taraboletti, A; Walker, T, 2017)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (50.00)24.3611
2020's1 (50.00)2.80

Authors

AuthorsStudies
Suto, DJ1
Nair, G1
Sudarshana, DM1
Steele, SU1
Dwyer, J1
Beck, ES1
Ohayon, J1
McFarland, H1
Koretsky, AP1
Cortese, ICM1
Reich, DS1
Taraboletti, A1
Walker, T1
Avila, R1
Huang, H1
Caporoso, J1
Manandhar, E1
Leeper, TC1
Modarelli, DA1
Medicetty, S1
Shriver, LP1

Other Studies

2 other studies available for pyridoxal phosphate and Multiple Sclerosis

ArticleYear
Manganese-Enhanced MRI in Patients with Multiple Sclerosis.
    AJNR. American journal of neuroradiology, 2020, Volume: 41, Issue:9

    Topics: Adult; Animals; Contrast Media; Edetic Acid; Female; Humans; Injections, Intravenous; Magnetic Reson

2020
Cuprizone Intoxication Induces Cell Intrinsic Alterations in Oligodendrocyte Metabolism Independent of Copper Chelation.
    Biochemistry, 2017, 03-14, Volume: 56, Issue:10

    Topics: Amino Acids; Animals; Brain; Brain Chemistry; Cell Line; Chelating Agents; Copper; Cuprizone; Demyel

2017