pyridoxal phosphate has been researched along with Metabolism, Inborn Errors in 15 studies
Pyridoxal Phosphate: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
pyridoxal 5'-phosphate : The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.
Metabolism, Inborn Errors: Errors in metabolic processes resulting from inborn genetic mutations that are inherited or acquired in utero.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Elevated concentrations of pipecolic acid have been reported in plasma and CSF of patients with pyridoxine-dependent epilepsy, but its molecular background is unclear." | 3.73 | Pipecolic acid concentrations in brain tissue of nutritionally pyridoxine-deficient rats. ( Hoeger, H; Jakobs, C; Leschnik, M; Muehl, A; Plecko, B; Stoeckler-Ipsiroglu, S; Stromberger, C; Struys, E, 2005) |
| "Vitamin B(6) dependent seizure disorders are an important and treatable cause of childhood epilepsy." | 1.39 | Measurement of plasma B6 vitamer profiles in children with inborn errors of vitamin B6 metabolism using an LC-MS/MS method. ( Clayton, PT; Footitt, EJ; Heales, SJ; Mills, K; Mills, PB; Neergheen, V; Oppenheim, M, 2013) |
| "Neonatal epileptic encephalopathy can be caused by inborn errors of metabolism." | 1.34 | Pyridoxal 5'-phosphate may be curative in early-onset epileptic encephalopathy. ( Bagci, S; Bast, T; Baumgartner, MR; Clayton, PT; Franz, AR; Hoffmann, GF; Mills, PB; Schmitt, B; Steinmann, B; Strehl, H; Wagner, N; Windfuhr, M; Wolf, NI; Zschocke, J, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (46.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 4 (26.67) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Ghatge, MS | 1 |
| Al Mughram, M | 1 |
| Omar, AM | 1 |
| Safo, MK | 1 |
| Cellini, B | 1 |
| Montioli, R | 1 |
| Oppici, E | 1 |
| Astegno, A | 1 |
| Voltattorni, CB | 1 |
| Mathis, D | 1 |
| Abela, L | 1 |
| Albersen, M | 1 |
| Bürer, C | 1 |
| Crowther, L | 1 |
| Beese, K | 1 |
| Hartmann, H | 1 |
| Bok, LA | 1 |
| Struys, E | 2 |
| Papuc, SM | 1 |
| Rauch, A | 1 |
| Hersberger, M | 1 |
| Verhoeven-Duif, NM | 1 |
| Plecko, B | 2 |
| Pearl, PL | 1 |
| Gospe, SM | 1 |
| Footitt, EJ | 2 |
| Heales, SJ | 2 |
| Mills, PB | 3 |
| Allen, GF | 1 |
| Oppenheim, M | 2 |
| Clayton, PT | 3 |
| Mills, K | 1 |
| Neergheen, V | 1 |
| Hoeger, H | 1 |
| Jakobs, C | 1 |
| Stromberger, C | 1 |
| Leschnik, M | 1 |
| Muehl, A | 1 |
| Stoeckler-Ipsiroglu, S | 1 |
| Hoffmann, GF | 1 |
| Schmitt, B | 1 |
| Windfuhr, M | 1 |
| Wagner, N | 1 |
| Strehl, H | 1 |
| Bagci, S | 1 |
| Franz, AR | 1 |
| Baumgartner, MR | 1 |
| Steinmann, B | 1 |
| Bast, T | 1 |
| Wolf, NI | 1 |
| Zschocke, J | 1 |
| Shideler, CE | 1 |
| Mudd, SH | 1 |
| Arakawa, T | 1 |
| Tamura, T | 1 |
| Higashi, O | 1 |
| Ohara, K | 1 |
| Tanno, K | 1 |
| Ebadi, MS | 1 |
| Bostad, R | 1 |
| Pellegrino, RJ | 1 |
| Rosenberg, LE | 1 |
| Lilljeqvist, A | 1 |
| Hsia, YE | 1 |
5 reviews available for pyridoxal phosphate and Metabolism, Inborn Errors
| Article | Year |
|---|---|
Inborn errors in the vitamin B6 salvage enzymes associated with neonatal epileptic encephalopathy and other pathologies.
Topics: Animals; Brain Diseases, Metabolic; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Metabolism, In | 2021 |
The chaperone role of the pyridoxal 5'-phosphate and its implications for rare diseases involving B6-dependent enzymes.
Topics: Animals; Coenzymes; Humans; Metabolism, Inborn Errors; Molecular Chaperones; Protein Folding; Proteo | 2014 |
Vitamin B6: an overview.
Topics: Adult; Animals; Chemical Phenomena; Chemistry; Child; Female; Humans; Infant; Metabolism, Inborn Err | 1983 |
Vitamin-responsive genetic abnormalities.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Apoenzymes; Cystathionine beta-Synthase; Genetic | 1982 |
Fate of vitamin B 6 in the I-strain mouse.
Topics: Alcohol Oxidoreductases; Animals; Carboxylic Acids; Intestinal Absorption; Metabolism, Inborn Errors | 1972 |
10 other studies available for pyridoxal phosphate and Metabolism, Inborn Errors
| Article | Year |
|---|---|
The value of plasma vitamin B6 profiles in early onset epileptic encephalopathies.
Topics: Adolescent; Adult; Biomarkers; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Mal | 2016 |
Pyridoxal phosphate dependency, a newly recognized treatable catastrophic epileptic encephalopathy.
Topics: Aldehyde Dehydrogenase; Epilepsy; Humans; Infant, Newborn; Metabolism, Inborn Errors; Pyridoxal Phos | 2007 |
Pyridoxal 5'-phosphate in cerebrospinal fluid; factors affecting concentration.
Topics: Adolescent; Adult; Biopterins; Child; Child, Preschool; Cysteine; Epilepsy; False Positive Reactions | 2011 |
Measurement of plasma B6 vitamer profiles in children with inborn errors of vitamin B6 metabolism using an LC-MS/MS method.
Topics: Adolescent; Child; Child, Preschool; Chromatography, Liquid; Epilepsy; Humans; Metabolism, Inborn Er | 2013 |
Pipecolic acid concentrations in brain tissue of nutritionally pyridoxine-deficient rats.
Topics: Animal Nutritional Physiological Phenomena; Animals; Brain; Disease Models, Animal; Epilepsy; Female | 2005 |
Pyridoxal 5'-phosphate may be curative in early-onset epileptic encephalopathy.
Topics: Age of Onset; Brain Diseases; Child, Preschool; Epilepsy; Female; Humans; Infant; Infant, Newborn; M | 2007 |
Genetic determination of coenzyme synthesis in red cells.
Topics: Disease Susceptibility; Erythrocytes; Humans; Metabolism, Inborn Errors; Pyridoxal Phosphate; Ribofl | 1981 |
Formiminotransferase deficiency syndrome associated with megaloblastic anemia responsive to pyridoxine or folic acid.
Topics: Anemia, Macrocytic; Blood Cell Count; Bone Marrow Examination; Cerebral Ventriculography; Erythrocyt | 1968 |
Impairment of pyridoxal phosphate dependent metabolic reactions in a child with subacute necrotizing encephalopathy.
Topics: 5-Hydroxytryptophan; Amines; Autopsy; Basal Ganglia; Brain Diseases; Carboxy-Lyases; Dopamine; Femal | 1969 |
Methylmalonic aciduria: metabolic block localization and vitamin B 12 dependency.
Topics: Acidosis; Amino Acid Metabolism, Inborn Errors; Carbon Dioxide; Carbon Isotopes; Coenzyme A; Humans; | 1968 |