pyridoxal phosphate has been researched along with Metabolic Diseases in 13 studies
Pyridoxal Phosphate: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
pyridoxal 5'-phosphate : The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.
Metabolic Diseases: Generic term for diseases caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality (METABOLISM, INBORN ERRORS) or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. (Stedman, 26th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Antiquitin deficiency is the most common form of pyridoxine-dependent epilepsy." | 5.05 | Inherited Disorders of Lysine Metabolism: A Review. ( Bouchereau, J; Schiff, M, 2020) |
| "In spite of effective seizure control with PLP, approximately 56% of patients affected with PLP-dependent epilepsy suffer developmental delay/intellectual disability." | 2.72 | Phenotypic and molecular spectrum of pyridoxamine-5'-phosphate oxidase deficiency: A scoping review of 87 cases of pyridoxamine-5'-phosphate oxidase deficiency. ( Abdelhakim, M; Adly, N; Alghamdi, M; Alghanem, B; Arold, ST; Bashiri, FA; Jamjoom, DZ; Sumaily, KM, 2021) |
| "About 7/18 (39%) of patients showed seizure-free with pyridoxine (PN) or pyridoxal-5'-phosphate treatment." | 1.91 | Analysis for variable manifestations and molecular characteristics of pyridox(am)ine-5'-phosphate oxidase (PNPO) deficiency. ( Gong, P; Jiao, X; Niu, Y; Xu, Z; Yang, Z; Zhang, Y, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (46.15) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 6 (46.15) | 2.80 |
| Authors | Studies |
|---|---|
| Barile, A | 1 |
| Mills, P | 1 |
| di Salvo, ML | 1 |
| Graziani, C | 1 |
| Bunik, V | 1 |
| Clayton, P | 1 |
| Contestabile, R | 1 |
| Tramonti, A | 1 |
| Jiao, X | 1 |
| Gong, P | 1 |
| Niu, Y | 1 |
| Xu, Z | 1 |
| Zhang, Y | 1 |
| Yang, Z | 1 |
| Gowda, VK | 1 |
| Srinivasan, VM | 1 |
| Alghamdi, M | 1 |
| Bashiri, FA | 1 |
| Abdelhakim, M | 1 |
| Adly, N | 1 |
| Jamjoom, DZ | 1 |
| Sumaily, KM | 1 |
| Alghanem, B | 1 |
| Arold, ST | 1 |
| Bouchereau, J | 1 |
| Schiff, M | 1 |
| Clayton, PT | 1 |
| ANGELINO, PF | 1 |
| VACCA, G | 1 |
| TROVATI, C | 1 |
| Surtees, R | 1 |
| Wolf, N | 1 |
| Benke, PJ | 1 |
| Fleshood, HL | 1 |
| Pitot, HC | 1 |
| Lissitzky, S | 1 |
| Laurent, B | 1 |
| Bernard, P | 1 |
| Fenasse, R | 1 |
| Heeley, AF | 1 |
| Roberts, GE | 1 |
| Ladner, HA | 1 |
| Schröder, K | 1 |
| Petres, J | 1 |
3 reviews available for pyridoxal phosphate and Metabolic Diseases
| Article | Year |
|---|---|
Phenotypic and molecular spectrum of pyridoxamine-5'-phosphate oxidase deficiency: A scoping review of 87 cases of pyridoxamine-5'-phosphate oxidase deficiency.
Topics: Brain Diseases, Metabolic; Epilepsy; Humans; Hypoxia-Ischemia, Brain; Metabolic Diseases; Mutation; | 2021 |
Inherited Disorders of Lysine Metabolism: A Review.
Topics: 2-Aminoadipic Acid; Aldehyde Dehydrogenase; Amino Acid Metabolism, Inborn Errors; Arginine; Brain; B | 2020 |
Oral contraceptive agents and vitamins.
Topics: Anemia, Macrocytic; Animals; Contraceptives, Oral; Estrogens; Female; Folic Acid; Glutamates; Humans | 1972 |
10 other studies available for pyridoxal phosphate and Metabolic Diseases
| Article | Year |
|---|---|
Characterization of Novel Pathogenic Variants Causing Pyridox(am)ine 5'-Phosphate Oxidase-Dependent Epilepsy.
Topics: Brain Diseases, Metabolic; Epilepsy; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Metabolic Dis | 2021 |
Analysis for variable manifestations and molecular characteristics of pyridox(am)ine-5'-phosphate oxidase (PNPO) deficiency.
Topics: Brain Diseases, Metabolic; Humans; Hypoxia-Ischemia, Brain; Metabolic Diseases; Oxidoreductases; Pho | 2023 |
Ohtahara and West Syndrome due to Pyridox(am)ine-5-Phosphate Oxidase (PNPO) Deficiency with Novel Phenotype and Good Outcome without Pyridoxal-5'-Phosphate.
Topics: Humans; Metabolic Diseases; Oxidoreductases; Phenotype; Phosphates; Pyridoxal Phosphate; Spasms, Inf | 2023 |
The effectiveness of correcting abnormal metabolic profiles.
Topics: 3-Hydroxysteroid Dehydrogenases; Administration, Oral; Bile Acids and Salts; Epilepsy; Humans; Metab | 2020 |
[EFFECTS OF PYRIDOXAL PHOSPHATE ON SOME METABOLIC DISORDERS].
Topics: Geriatrics; Heart Diseases; Humans; Metabolic Diseases; Pyridoxal Phosphate | 1965 |
Treatable neonatal epilepsy.
Topics: Biomarkers; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Leucovorin; Metabolic Dise | 2007 |
Osteoporotic bone disease in the pyridoxine-deficient rat.
Topics: Age Factors; Alkaline Phosphatase; Animal Nutritional Physiological Phenomena; Animals; Body Weight; | 1972 |
[Experimental studies in a case of tyrosinosis. New pathogenic hypothesis].
Topics: Adult; Amino Acids; Animals; Blood Glucose; Carbon Dioxide; Chromatography; Depression, Chemical; Di | 1969 |
A study of tryptophan metabolism in psychotic children.
Topics: Autoradiography; Carbon Isotopes; Child; Child, Preschool; Female; Humans; Kynurenine; Male; Metabol | 1966 |
[On the influence of pyridoxal-5-phosphate on decarboxylase depending metabolic disorders].
Topics: Amino Acids; Animals; Blood Chemical Analysis; Carboxy-Lyases; Dogs; Metabolic Diseases; Porphyrias; | 1966 |